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Conserved domains on  [gi|294661860|ref|NP_001170995|]
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hemT-3 protein isoform 1 precursor [Mus musculus]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_GML cd23555
extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like ...
 47-133 4.93e-52

extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like protein (GML) and similar proteins; GML may play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467085  Cd Length: 87  Bit Score: 161.00  E-value: 4.93e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661860  47 MRCHSCQEHNTFYCPHIHYCDMDIRRCLTVAIRVNLRLLYVYKHCTKDCTFIYRRHVPPELPRVLKDVKSFYFVLCCGSV 126
Cdd:cd23555    1 LRCHSCAVINTFNCPAHRTCPYDIRRCMTVAIRVNSRELLVYKNCTKNCTFVYAEEQPPEAPRKIPKTNSFYFVMCCSSM 80


                 ....*..
gi 294661860 127 VCNEGGP 133
Cdd:cd23555   81 FCNEGGP 87
 
Name Accession Description Interval E-value
TFP_LU_ECD_GML cd23555
extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like ...
 47-133 4.93e-52

extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like protein (GML) and similar proteins; GML may play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467085  Cd Length: 87  Bit Score: 161.00  E-value: 4.93e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661860  47 MRCHSCQEHNTFYCPHIHYCDMDIRRCLTVAIRVNLRLLYVYKHCTKDCTFIYRRHVPPELPRVLKDVKSFYFVLCCGSV 126
Cdd:cd23555    1 LRCHSCAVINTFNCPAHRTCPYDIRRCMTVAIRVNSRELLVYKNCTKNCTFVYAEEQPPEAPRKIPKTNSFYFVMCCSSM 80


                 ....*..
gi 294661860 127 VCNEGGP 133
Cdd:cd23555   81 FCNEGGP 87
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 48-133 6.95e-05

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 39.83  E-value: 6.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661860    48 RCHSCQEHNTFYCPHIHYCDMDIRRCLTVAIRVNL--RLLYVYKHCTK--DCTFIYRRHVppelprvlKDVKSFYFVLCC 123
Cdd:smart00134   2 QCYSCTGNPDSSCSSEEECRSPDDVCLTVVAEVISdsRGSVVYKGCATspICPGSHGYEI--------NLTIAFLKVSCC 73

                           90
                   ....*....|
gi 294661860   124 GSVVCNEGGP 133
Cdd:smart00134  74 QTDLCNAAGP 83
 
Name Accession Description Interval E-value
TFP_LU_ECD_GML cd23555
extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like ...
 47-133 4.93e-52

extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like protein (GML) and similar proteins; GML may play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467085  Cd Length: 87  Bit Score: 161.00  E-value: 4.93e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661860  47 MRCHSCQEHNTFYCPHIHYCDMDIRRCLTVAIRVNLRLLYVYKHCTKDCTFIYRRHVPPELPRVLKDVKSFYFVLCCGSV 126
Cdd:cd23555    1 LRCHSCAVINTFNCPAHRTCPYDIRRCMTVAIRVNSRELLVYKNCTKNCTFVYAEEQPPEAPRKIPKTNSFYFVMCCSSM 80


                 ....*..
gi 294661860 127 VCNEGGP 133
Cdd:cd23555   81 FCNEGGP 87
TFP_LU_ECD_Ly6K cd23550
extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K ...
 47-133 4.13e-14

extracellular domain (ECD) found in lymphocyte antigen 6K (Ly-6K) and similar proteins; Ly-6K is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth. Ly-6K contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467080  Cd Length: 86  Bit Score: 64.26  E-value: 4.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661860  47 MRCHSCQEHNTFYCPHIHYCDMDIRRCLTVAIRVNLRLLYVYKHCTKDCTFIYRRHVPPElPRVLKDVKSFYFVLCCGSV 126
Cdd:cd23550    1 LTCHVCEVENSFNCTNPVTCTWEETYCVLAAVRIFPRFFLVSKQCSKYCPVVEVPPPPPK-SFVLEKPMPFLYIKCCREN 79


                 ....*..
gi 294661860 127 VCNEGGP 133
Cdd:cd23550   80 LCNEEGP 86
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 48-133 6.95e-05

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 39.83  E-value: 6.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661860    48 RCHSCQEHNTFYCPHIHYCDMDIRRCLTVAIRVNL--RLLYVYKHCTK--DCTFIYRRHVppelprvlKDVKSFYFVLCC 123
Cdd:smart00134   2 QCYSCTGNPDSSCSSEEECRSPDDVCLTVVAEVISdsRGSVVYKGCATspICPGSHGYEI--------NLTIAFLKVSCC 73

                           90
                   ....*....|
gi 294661860   124 GSVVCNEGGP 133
Cdd:smart00134  74 QTDLCNAAGP 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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