NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|295424108|ref|NP_001171338|]
View 

shugoshin 2 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Pneumo_att_G super family cl25814
Pneumovirinae attachment membrane glycoprotein G;
35-228 3.78e-03

Pneumovirinae attachment membrane glycoprotein G;


The actual alignment was detected with superfamily member pfam05539:

Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 40.80  E-value: 3.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295424108    35 SATKKQRNSKQCKPAHLPYArvllTSENDDDDGADDKWQTKCNNRTISKTSPDSTSSVSRQPSSLHQcnlkAFPPKEDNQ 114
Cdd:pfam05539  171 AVTTSKTTSWPTEVSHPTYP----SQVTPQSQPATQGHQTATANQRLSSTEPVGTQGTTTSSNPEPQ----TEPPPSQRG 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295424108   115 KTCGSGHLEHTSSVDILPNESHSDQSPKsslseMKTAPSPSLRREKLSHGNvtmrkkcVSSTPDILYVTDLDHQPTSSPG 194
Cdd:pfam05539  243 PSGSPQHPPSTTSQDQSTTGDGQEHTQR-----RKTPPATSNRRSPHSTAT-------PPPTTKRQETGRPTPRPTATTQ 310

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 295424108   195 SNWNNEIHGHTNETSN-NTQRNAECFLDLPSESSS 228
Cdd:pfam05539  311 SGSSPPHSSPPGVQANpTTQNLVDCKELDPPKPNS 345
Shugoshin_C pfam07557
Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C ...
 1043-1064 8.11e-03

Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C terminus, which is rich in basic amino-acids. Shugoshin (Sgo1) protects Rec8 at centromeres during anaphase I (during meiosis) so that sister chromatids remain tethered. Sgo2 is a paralogue of Sgo1 and is involved in correctly orienting sister-centromeres.


:

Pssm-ID: 462207  Cd Length: 24  Bit Score: 34.76  E-value: 8.11e-03
                           10        20
                   ....*....|....*....|...
gi 295424108  1043 RRKRQCV-PLNLTEPSLRSKMRR 1064
Cdd:pfam07557    2 RPSRRARkPVSYKEPSLRSKMRR 24
 
Name Accession Description Interval E-value
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
35-228 3.78e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 40.80  E-value: 3.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295424108    35 SATKKQRNSKQCKPAHLPYArvllTSENDDDDGADDKWQTKCNNRTISKTSPDSTSSVSRQPSSLHQcnlkAFPPKEDNQ 114
Cdd:pfam05539  171 AVTTSKTTSWPTEVSHPTYP----SQVTPQSQPATQGHQTATANQRLSSTEPVGTQGTTTSSNPEPQ----TEPPPSQRG 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295424108   115 KTCGSGHLEHTSSVDILPNESHSDQSPKsslseMKTAPSPSLRREKLSHGNvtmrkkcVSSTPDILYVTDLDHQPTSSPG 194
Cdd:pfam05539  243 PSGSPQHPPSTTSQDQSTTGDGQEHTQR-----RKTPPATSNRRSPHSTAT-------PPPTTKRQETGRPTPRPTATTQ 310

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 295424108   195 SNWNNEIHGHTNETSN-NTQRNAECFLDLPSESSS 228
Cdd:pfam05539  311 SGSSPPHSSPPGVQANpTTQNLVDCKELDPPKPNS 345
Shugoshin_C pfam07557
Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C ...
 1043-1064 8.11e-03

Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C terminus, which is rich in basic amino-acids. Shugoshin (Sgo1) protects Rec8 at centromeres during anaphase I (during meiosis) so that sister chromatids remain tethered. Sgo2 is a paralogue of Sgo1 and is involved in correctly orienting sister-centromeres.


Pssm-ID: 462207  Cd Length: 24  Bit Score: 34.76  E-value: 8.11e-03
                           10        20
                   ....*....|....*....|...
gi 295424108  1043 RRKRQCV-PLNLTEPSLRSKMRR 1064
Cdd:pfam07557    2 RPSRRARkPVSYKEPSLRSKMRR 24
 
Name Accession Description Interval E-value
Pneumo_att_G pfam05539
Pneumovirinae attachment membrane glycoprotein G;
35-228 3.78e-03

Pneumovirinae attachment membrane glycoprotein G;


Pssm-ID: 114270 [Multi-domain]  Cd Length: 408  Bit Score: 40.80  E-value: 3.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295424108    35 SATKKQRNSKQCKPAHLPYArvllTSENDDDDGADDKWQTKCNNRTISKTSPDSTSSVSRQPSSLHQcnlkAFPPKEDNQ 114
Cdd:pfam05539  171 AVTTSKTTSWPTEVSHPTYP----SQVTPQSQPATQGHQTATANQRLSSTEPVGTQGTTTSSNPEPQ----TEPPPSQRG 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295424108   115 KTCGSGHLEHTSSVDILPNESHSDQSPKsslseMKTAPSPSLRREKLSHGNvtmrkkcVSSTPDILYVTDLDHQPTSSPG 194
Cdd:pfam05539  243 PSGSPQHPPSTTSQDQSTTGDGQEHTQR-----RKTPPATSNRRSPHSTAT-------PPPTTKRQETGRPTPRPTATTQ 310

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 295424108   195 SNWNNEIHGHTNETSN-NTQRNAECFLDLPSESSS 228
Cdd:pfam05539  311 SGSSPPHSSPPGVQANpTTQNLVDCKELDPPKPNS 345
Shugoshin_C pfam07557
Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C ...
 1043-1064 8.11e-03

Shugoshin C terminus; Shugoshin-like proteins contain this conserved sequence at the C terminus, which is rich in basic amino-acids. Shugoshin (Sgo1) protects Rec8 at centromeres during anaphase I (during meiosis) so that sister chromatids remain tethered. Sgo2 is a paralogue of Sgo1 and is involved in correctly orienting sister-centromeres.


Pssm-ID: 462207  Cd Length: 24  Bit Score: 34.76  E-value: 8.11e-03
                           10        20
                   ....*....|....*....|...
gi 295424108  1043 RRKRQCV-PLNLTEPSLRSKMRR 1064
Cdd:pfam07557    2 RPSRRARkPVSYKEPSLRSKMRR 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH