NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|300794137|ref|NP_001178602|]
View 

T-lymphocyte surface antigen Ly-9 precursor [Rattus norvegicus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 11617254)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 53-152 7.23e-41

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


:

Pssm-ID: 409517  Cd Length: 102  Bit Score: 144.00  E-value: 7.23e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137  53 RVISGILGGSVTFPLNISINAEIELITWTylSKTLVLAITS----RSGITILLKEYSGRLNISQDGYSLCMSNLTKSDSG 128
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWS--FKTSLAVIAPgeggAPEIIITDKSYKERLNISQNDYSLQISNLTMEDAG 78

                         90       100
                 ....*....|....*....|....
gi 300794137 129 SYQAQIIQKNVDHTVRNEFILHIY 152
Cdd:cd16842   79 SYRARINTKNSRVTITKEFTLHIY 102
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 254-357 2.71e-25

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd16842:

Pssm-ID: 472250  Cd Length: 102  Bit Score: 100.47  E-value: 2.71e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137 254 KTVIGILGEPVTLSLEFPASEETKNVVWVFNTSVISQEPKGAATvdPHRHKSKSSEERRLRISDQDSSLKISQLKMEDTG 333
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGA--PEIIITDKSYKERLNISQNDYSLQISNLTMEDAG 78

                         90       100
                 ....*....|....*....|....
gi 300794137 334 PYHAYVCSETSRGPSVRHFTLLVY 357
Cdd:cd16842   79 SYRARINTKNSRVTITKEFTLHIY 102
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 171-239 1.03e-06

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


:

Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 46.62  E-value: 1.03e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300794137  171 DSCTVTLICTVNGsKDGVQYSWIQKDTHNKTSHESHILRVSpsACDPDLpYTCTARNPVSQNSSQPVRV 239
Cdd:pfam13895  13 EGEPVTLTCSAPG-NPPPSYTWYKDGSAISSSPNFFTLSVS--AEDSGT-YTCVARNGRGGKVSNPVEL 77
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 363-432 3.80e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam08205:

Pssm-ID: 472250  Cd Length: 89  Bit Score: 37.01  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137  363 PNVTQSPVHMTNGICEVVLTCSVEGGEKDVRYTW----MPL-----------QKETVMSQGKSHLNVSWKIGERlpNFTC 427
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWyldgKPLeaaetsseqdpESGLVTVTSELKLVPSRSDHGQ--SLTC 78


                  ....*
gi 300794137  428 TTHNP 432
Cdd:pfam08205  79 QVSYG 83
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 53-152 7.23e-41

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 144.00  E-value: 7.23e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137  53 RVISGILGGSVTFPLNISINAEIELITWTylSKTLVLAITS----RSGITILLKEYSGRLNISQDGYSLCMSNLTKSDSG 128
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWS--FKTSLAVIAPgeggAPEIIITDKSYKERLNISQNDYSLQISNLTMEDAG 78

                         90       100
                 ....*....|....*....|....
gi 300794137 129 SYQAQIIQKNVDHTVRNEFILHIY 152
Cdd:cd16842   79 SYRARINTKNSRVTITKEFTLHIY 102
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 254-357 2.71e-25

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 100.47  E-value: 2.71e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137 254 KTVIGILGEPVTLSLEFPASEETKNVVWVFNTSVISQEPKGAATvdPHRHKSKSSEERRLRISDQDSSLKISQLKMEDTG 333
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGA--PEIIITDKSYKERLNISQNDYSLQISNLTMEDAG 78

                         90       100
                 ....*....|....*....|....
gi 300794137 334 PYHAYVCSETSRGPSVRHFTLLVY 357
Cdd:cd16842   79 SYRARINTKNSRVTITKEFTLHIY 102
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 171-239 1.03e-06

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 46.62  E-value: 1.03e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300794137  171 DSCTVTLICTVNGsKDGVQYSWIQKDTHNKTSHESHILRVSpsACDPDLpYTCTARNPVSQNSSQPVRV 239
Cdd:pfam13895  13 EGEPVTLTCSAPG-NPPPSYTWYKDGSAISSSPNFFTLSVS--AEDSGT-YTCVARNGRGGKVSNPVEL 77
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 50-138 1.46e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 47.07  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137   50 TPPRVISGILGGSVTFP--LNISINAEIELITWTYL----SKTLVLAITSRSGITILLKE-YSGRLNISQDGYSLCMSNL 122
Cdd:pfam07686   1 QTPREVTVALGGSVTLPctYSSSMSEASTSVYWYRQppgkGPTFLIAYYSNGSEEGVKKGrFSGRGDPSNGDGSLTIQNL 80

                          90
                  ....*....|....*.
gi 300794137  123 TKSDSGSYQAQIIQKN 138
Cdd:pfam07686  81 TLSDSGTYTCAVIPSG 96
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 363-432 3.80e-03

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 37.01  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137  363 PNVTQSPVHMTNGICEVVLTCSVEGGEKDVRYTW----MPL-----------QKETVMSQGKSHLNVSWKIGERlpNFTC 427
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWyldgKPLeaaetsseqdpESGLVTVTSELKLVPSRSDHGQ--SLTC 78


                  ....*
gi 300794137  428 TTHNP 432
Cdd:pfam08205  79 QVSYG 83
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 254-357 5.65e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 37.05  E-value: 5.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137  254 KTVIGILGEPVTLSLEFPASEETKNVV--WVFNTSVISQEPKGAATVdPHRHKSKSSE--ERRLRISDQDSSLKISQLKM 329
Cdd:pfam07686   4 REVTVALGGSVTLPCTYSSSMSEASTSvyWYRQPPGKGPTFLIAYYS-NGSEEGVKKGrfSGRGDPSNGDGSLTIQNLTL 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 300794137  330 EDTGPYHayvCSETSRGPSV--RHFTLLVY 357
Cdd:pfam07686  83 SDSGTYT---CAVIPSGEGVfgKGTRLTVL 109
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 158-237 6.00e-03

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 36.22  E-value: 6.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137 158 PQVTVKSMTSSENDScTVTLICTVNGskDGVQYSWIQkdthNKTS-HESHILRVSPSACDPDL---------PYTCTARN 227
Cdd:cd05740    2 PFISSNNSNPVEDKD-AVTLTCEPET--QNTSYLWWF----NGQSlPVTPRLTLSNGNRTLTLlnvtredagAYQCEISN 74

                         90
                 ....*....|
gi 300794137 228 PVSQNSSQPV 237
Cdd:cd05740   75 PVSANRSDPV 84
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 53-152 7.23e-41

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 144.00  E-value: 7.23e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137  53 RVISGILGGSVTFPLNISINAEIELITWTylSKTLVLAITS----RSGITILLKEYSGRLNISQDGYSLCMSNLTKSDSG 128
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWS--FKTSLAVIAPgeggAPEIIITDKSYKERLNISQNDYSLQISNLTMEDAG 78

                         90       100
                 ....*....|....*....|....
gi 300794137 129 SYQAQIIQKNVDHTVRNEFILHIY 152
Cdd:cd16842   79 SYRARINTKNSRVTITKEFTLHIY 102
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 254-357 2.71e-25

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 100.47  E-value: 2.71e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137 254 KTVIGILGEPVTLSLEFPASEETKNVVWVFNTSVISQEPKGAATvdPHRHKSKSSEERRLRISDQDSSLKISQLKMEDTG 333
Cdd:cd16842    1 KEVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGA--PEIIITDKSYKERLNISQNDYSLQISNLTMEDAG 78

                         90       100
                 ....*....|....*....|....
gi 300794137 334 PYHAYVCSETSRGPSVRHFTLLVY 357
Cdd:cd16842   79 SYRARINTKNSRVTITKEFTLHIY 102
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 55-152 1.25e-08

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 52.74  E-value: 1.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137  55 ISGILGGSVTFPLNiSINAEIELITWTYlSKTLVLAITSRSGITILlKEYSGRLNISQDGYSLCMSNLTKSDSGSYQAQI 134
Cdd:cd05775    5 VYGALGGNVTLTIS-SLQDDIDEIKWKK-TKDKIVEWENNIGPTYF-GSFKDRVLLDKESGSLTIKNLTKEDSGTYELEI 81

                         90
                 ....*....|....*...
gi 300794137 135 IQKNVDHTVRNeFILHIY 152
Cdd:cd05775   82 TSTNGKVLSSK-FTLEVL 98
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 171-239 1.03e-06

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 46.62  E-value: 1.03e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 300794137  171 DSCTVTLICTVNGsKDGVQYSWIQKDTHNKTSHESHILRVSpsACDPDLpYTCTARNPVSQNSSQPVRV 239
Cdd:pfam13895  13 EGEPVTLTCSAPG-NPPPSYTWYKDGSAISSSPNFFTLSVS--AEDSGT-YTCVARNGRGGKVSNPVEL 77
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 50-138 1.46e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 47.07  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137   50 TPPRVISGILGGSVTFP--LNISINAEIELITWTYL----SKTLVLAITSRSGITILLKE-YSGRLNISQDGYSLCMSNL 122
Cdd:pfam07686   1 QTPREVTVALGGSVTLPctYSSSMSEASTSVYWYRQppgkGPTFLIAYYSNGSEEGVKKGrFSGRGDPSNGDGSLTIQNL 80

                          90
                  ....*....|....*.
gi 300794137  123 TKSDSGSYQAQIIQKN 138
Cdd:pfam07686  81 TLSDSGTYTCAVIPSG 96
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 254-357 1.74e-04

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 41.18  E-value: 1.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137 254 KTVIGILGEPVTL-SLEFPAseETKNVVWVFNTSVIsqepkgaATVDPHRHKS-KSSEERRLRISDQDSSLKISQLKMED 331
Cdd:cd05775    3 GEVYGALGGNVTLtISSLQD--DIDEIKWKKTKDKI-------VEWENNIGPTyFGSFKDRVLLDKESGSLTIKNLTKED 73

                         90       100
                 ....*....|....*....|....*.
gi 300794137 332 TGPYHAYVcSETSRGPSVRHFTLLVY 357
Cdd:cd05775   74 SGTYELEI-TSTNGKVLSSKFTLEVL 98
IgV_1_Nectin-2_NecL-5_like_CD112_CD155 cd20989
First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar ...
 51-134 9.46e-04

First immunoglobulin variable (IgV) domain of nectin-2, nectin-like protein 5, and similar domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.


Pssm-ID: 409581  Cd Length: 112  Bit Score: 39.48  E-value: 9.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137  51 PPRViSGILGGSVTFPLNISIN---AEIELITWTYL-SKTLVLAITSRSGITI----LLKEYSGRLNISQDGYSLCMSNL 122
Cdd:cd20989    6 PPEV-RGFLGGSVTLPCHLLPPnmvTHVSQVTWQRHdEHGSVAVFHPKQGPSFpeseRLSFVAARLGAELRNASLAMFGL 84

                         90
                 ....*....|..
gi 300794137 123 TKSDSGSYQAQI 134
Cdd:cd20989   85 RVEDEGNYTCEF 96
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 363-432 3.80e-03

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 37.01  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137  363 PNVTQSPVHMTNGICEVVLTCSVEGGEKDVRYTW----MPL-----------QKETVMSQGKSHLNVSWKIGERlpNFTC 427
Cdd:pfam08205   1 PTIEPPASLLEGEGPEVVATCSSAGGKPAPRITWyldgKPLeaaetsseqdpESGLVTVTSELKLVPSRSDHGQ--SLTC 78


                  ....*
gi 300794137  428 TTHNP 432
Cdd:pfam08205  79 QVSYG 83
IgV_CEACAM_D1 cd05774
First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 95-138 3.91e-03

First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM); The members here are composed of the immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) proteins. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface.


Pssm-ID: 409430  Cd Length: 105  Bit Score: 37.25  E-value: 3.91e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 300794137  95 SGITILLKEYSGRLNISQDGySLCMSNLTKSDSGSYQAQIIQKN 138
Cdd:cd05774   51 TNSSTPGPAYSGRETIYPNG-SLLIQNVTQKDTGFYTLQTITAD 93
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 254-357 5.65e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 37.05  E-value: 5.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137  254 KTVIGILGEPVTLSLEFPASEETKNVV--WVFNTSVISQEPKGAATVdPHRHKSKSSE--ERRLRISDQDSSLKISQLKM 329
Cdd:pfam07686   4 REVTVALGGSVTLPCTYSSSMSEASTSvyWYRQPPGKGPTFLIAYYS-NGSEEGVKKGrfSGRGDPSNGDGSLTIQNLTL 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 300794137  330 EDTGPYHayvCSETSRGPSV--RHFTLLVY 357
Cdd:pfam07686  83 SDSGTYT---CAVIPSGEGVfgKGTRLTVL 109
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 158-237 6.00e-03

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 36.22  E-value: 6.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794137 158 PQVTVKSMTSSENDScTVTLICTVNGskDGVQYSWIQkdthNKTS-HESHILRVSPSACDPDL---------PYTCTARN 227
Cdd:cd05740    2 PFISSNNSNPVEDKD-AVTLTCEPET--QNTSYLWWF----NGQSlPVTPRLTLSNGNRTLTLlnvtredagAYQCEISN 74

                         90
                 ....*....|
gi 300794137 228 PVSQNSSQPV 237
Cdd:cd05740   75 PVSANRSDPV 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH