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Conserved domains on  [gi|300794741|ref|NP_001178633|]
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fibronectin type III domain-containing protein 3B [Rattus norvegicus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10047016)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to fibronectin type-III domain-containing protein 3A/3B

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
540-771 1.95e-19

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 93.91  E-value: 1.95e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  540 NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRplLKG-PVTSHGFSVKWDAPKDNGGSEilkYLLEItdGA 618
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG--LTAtADTPGSVTLSWDPVTESDATG---YRVYR--SN 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  619 SEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCIGTGG-HSQCSESLPVRTLSLAPGqcrPPRVL--GRPKHKEVHLEW 695
Cdd:COG3401   271 SGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  696 DVPASEGgceVSEYSVE-----MTEPEEVASEVyhgPELECTVGNLLPGTVYRFRVRALNDGG-YGPYSDVSEITTAAGP 769
Cdd:COG3401   348 TASSDAD---VTGYNVYrstsgGGTYTKIAETV---TTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAA 421


                  ..
gi 300794741  770 PG 771
Cdd:COG3401   422 SG 423
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
732-1059 3.58e-17

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 86.59  E-value: 3.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  732 TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPgqcRAPC---VSFTPDGCVLVGWESPESPGADisEFRLEWG 808
Cdd:COG3401   195 GGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPP---SAPTgltATADTPGSVTLSWDPVTESDAT--GYRVYRS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  809 EDE-ESLELIYHGPDTCFEIRDLLPAAQYCCRLQAFNPAG-AGPYSELVHCQTPASAPDPVSTLCVleeeplSAHLDSpS 886
Cdd:COG3401   270 NSGdGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTA------TAVGSS-S 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  887 VclVLTWEEpcSNGSEIIAYNI----DLGDTCITVG---NTTTHVLKNLLPETTYRIRIQAVNDIGD-GPFSQFIKAKTR 958
Cdd:COG3401   343 I--TLSWTA--SSDADVTGYNVyrstSGGGTYTKIAetvTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTA 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  959 PLPPSPPRLECAASGPQSLKLKWGDSNSKIHAAHDMVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQATSe 1038
Cdd:COG3401   419 SAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV- 497

                         330       340
                  ....*....|....*....|.
gi 300794741 1039 AGEGPFSDTYTFSTTKSVPPT 1059
Cdd:COG3401   498 GGSGASSVTNSVSVIGASAAA 518
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 481-570 1.29e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  481 PSAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDNHFHPRYTGEDLTCTVKNLKRSTQYKFRLTASNT 556
Cdd:cd00063     1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 300794741  557 EGKSCPSEVLVCTT 570
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-473 3.05e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 3.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  382 PECPFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEgKRNSGFRQC--FFGGQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 300794741  460 IGTSGYSQEVVCYT 473
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 2.70e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 2.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  283 EKPQVSNIQARAVVLSWAPPVGLPCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAM 361
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 300794741  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1017-1149 2.10e-07

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 55.39  E-value: 2.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741 1017 TYKVQRLTEFTCYSFRIQATSEAGEGPFSDTYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMkgDPVNYVLQ 1093
Cdd:COG3401   193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTES--DATGYRVY 267

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 300794741 1094 VLVGRESEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1149
Cdd:COG3401   268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
SOBP super family cl25880
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ...
 50-163 6.29e-03

Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.


The actual alignment was detected with superfamily member pfam15279:

Pssm-ID: 464609 [Multi-domain]  Cd Length: 325  Bit Score: 40.18  E-value: 6.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741    50 TIRAEDGTLQCIQGPAEVPMMSPNGSIP-PIHVPPGYISQvieDSTGVRRVVVTPQSPECYPPSYpsAMSPTH--HLPPY 126
Cdd:pfam15279  169 TPRGLLGKPQQHPPPSPLPAFMEPSSMPpPFLRPPPSIPQ---PNSPLSNPMLPGIGPPPKPPRN--LGPPSNpmHRPPF 243

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 300794741   127 LTHHPhfiQNSHTAYYPPVTVPGDMPPQFFPQPHLPP 163
Cdd:pfam15279  244 SPHHP---PPPPTPPGPPPGLPPPPPRGFTPPFGPPF 277
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
540-771 1.95e-19

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 93.91  E-value: 1.95e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  540 NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRplLKG-PVTSHGFSVKWDAPKDNGGSEilkYLLEItdGA 618
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG--LTAtADTPGSVTLSWDPVTESDATG---YRVYR--SN 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  619 SEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCIGTGG-HSQCSESLPVRTLSLAPGqcrPPRVL--GRPKHKEVHLEW 695
Cdd:COG3401   271 SGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  696 DVPASEGgceVSEYSVE-----MTEPEEVASEVyhgPELECTVGNLLPGTVYRFRVRALNDGG-YGPYSDVSEITTAAGP 769
Cdd:COG3401   348 TASSDAD---VTGYNVYrstsgGGTYTKIAETV---TTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAA 421


                  ..
gi 300794741  770 PG 771
Cdd:COG3401   422 SG 423
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
732-1059 3.58e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 86.59  E-value: 3.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  732 TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPgqcRAPC---VSFTPDGCVLVGWESPESPGADisEFRLEWG 808
Cdd:COG3401   195 GGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPP---SAPTgltATADTPGSVTLSWDPVTESDAT--GYRVYRS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  809 EDE-ESLELIYHGPDTCFEIRDLLPAAQYCCRLQAFNPAG-AGPYSELVHCQTPASAPDPVSTLCVleeeplSAHLDSpS 886
Cdd:COG3401   270 NSGdGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTA------TAVGSS-S 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  887 VclVLTWEEpcSNGSEIIAYNI----DLGDTCITVG---NTTTHVLKNLLPETTYRIRIQAVNDIGD-GPFSQFIKAKTR 958
Cdd:COG3401   343 I--TLSWTA--SSDADVTGYNVyrstSGGGTYTKIAetvTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTA 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  959 PLPPSPPRLECAASGPQSLKLKWGDSNSKIHAAHDMVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQATSe 1038
Cdd:COG3401   419 SAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV- 497

                         330       340
                  ....*....|....*....|.
gi 300794741 1039 AGEGPFSDTYTFSTTKSVPPT 1059
Cdd:COG3401   498 GGSGASSVTNSVSVIGASAAA 518
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 674-765 4.20e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.06  E-value: 4.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  674 PGQCRPPRVLGRPKHkEVHLEWDVPASEGGcEVSEYSVEMTEPEEVASEVY---HGPELECTVGNLLPGTVYRFRVRALN 750
Cdd:cd00063     1 PSPPTNLRVTDVTST-SVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 300794741  751 DGGYGPYSDVSEITT 765
Cdd:cd00063    79 GGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
889-950 1.01e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 1.01e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741   889 LVLTWEEPCSNGSEIIAYNIDLGD--------TCITVGNTTTHVLKNLLPETTYRIRIQAVNDIGDGPFS 950
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYRPknsgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 481-570 1.29e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  481 PSAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDNHFHPRYTGEDLTCTVKNLKRSTQYKFRLTASNT 556
Cdd:cd00063     1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 300794741  557 EGKSCPSEVLVCTT 570
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-473 3.05e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 3.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  382 PECPFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEgKRNSGFRQC--FFGGQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 300794741  460 IGTSGYSQEVVCYT 473
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 889-957 7.47e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 7.47e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300794741  889 LVLTWEEPCSNGSEIIAYNI----DLGDTCITV----GNTTTHVLKNLLPETTYRIRIQAVNDIGDGPFSQFIKAKT 957
Cdd:cd00063    17 VTLSWTPPEDDGGPITGYVVeyreKGSGDWKEVevtpGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
385-466 2.07e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 2.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741   385 PFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEGKRNSGFRQCF-FGGQKHCKLTKLCPAMGYTFRLAARNDIGTS 463
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 300794741   464 GYS 466
Cdd:pfam00041   83 PPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 674-755 4.67e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 4.67e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741    674 PGQCRPPRVLGRPKHkEVHLEWDVPASEGG-CEVSEYSVEMTEPEEVASEVYHGP-ELECTVGNLLPGTVYRFRVRALND 751
Cdd:smart00060    1 PSPPSNLRVTDVTST-SVTLSWEPPPDDGItGYIVGYRVEYREEGSEWKEVNVTPsSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 300794741    752 GGYG 755
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
690-758 6.68e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.65  E-value: 6.68e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300794741   690 EVHLEWDVPASEGGcEVSEYSVE---MTEPEEVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 758
Cdd:pfam00041   15 SLTVSWTPPPDGNG-PITGYEVEyrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 2.70e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 2.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  283 EKPQVSNIQARAVVLSWAPPVGLPCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAM 361
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 300794741  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 864-947 2.79e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 2.79e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741    864 PDPVSTLCVLEEEPLSahldspsvcLVLTWEEPCSNG--SEIIAYNIDLGD------TCITVGNTTTHVLKNLLPETTYR 935
Cdd:smart00060    1 PSPPSNLRVTDVTSTS---------VTLSWEPPPDDGitGYIVGYRVEYREegsewkEVNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 300794741    936 IRIQAVNDIGDG 947
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 382-463 8.51e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 8.51e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741    382 PECPFPPKLAHRSKSSLTLQWKAPIDNG--SKITSYLLEWDEgKRNSGFRQCFFGGQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 300794741    460 IGTS 463
Cdd:smart00060   80 AGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1017-1149 2.10e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 55.39  E-value: 2.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741 1017 TYKVQRLTEFTCYSFRIQATSEAGEGPFSDTYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMkgDPVNYVLQ 1093
Cdd:COG3401   193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTES--DATGYRVY 267

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 300794741 1094 VLVGRESEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1149
Cdd:COG3401   268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
fn3 pfam00041
Fibronectin type III domain;
481-563 2.34e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.72  E-value: 2.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741   481 PSAPRLVRAGVTWITLQWSRPEGCSpEEVITYTLDIQEdENDNHFHPRYT--GEDLTCTVKNLKRSTQYKFRLTASNTEG 558
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGN-GPITGYEVEYRP-KNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 300794741   559 KSCPS 563
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 283-360 3.12e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 3.12e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300794741    283 EKPQVSNIQARAVVLSWAPPVglpcgPHGGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYA 360
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1057-1130 5.14e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 5.14e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300794741 1057 PPTLKAPRVTQLEGNSCEIFWETVPPMKGDPVNYVLQVLVGRESEYKQVYK--GEEATFQISGLQSNTDYRFRVCA 1130
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 481-560 5.19e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 5.19e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741    481 PSAPRLVRA---GVTWITLQWSRPEGCSPEE-VITYTLDIQEDENDNHFHPRyTGEDLTCTVKNLKRSTQYKFRLTASNT 556
Cdd:smart00060    1 PSPPSNLRVtdvTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 300794741    557 EGKS 560
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
285-360 2.22e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 2.22e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300794741   285 PQVSNIQARAVVLSWAPPvglpcgPHGGLSFpYSYEVALS--DKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYA 360
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPP------PDGNGPI-TGYEVEYRpkNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQA 75
fn3 pfam00041
Fibronectin type III domain;
1057-1130 3.46e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 3.46e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300794741  1057 PPTlkAPRVTQLEGNSCEIFWETVPPMKGDPVNYVLQVLVGRESEYKQVY--KGEEATFQISGLQSNTDYRFRVCA 1130
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1057-1130 5.26e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 5.26e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300794741   1057 PPTLKAPRVTQLEGNSCEIFWEtvPPMKGDPVNYVLQVLV---GRESEYKQVYKGEEAT-FQISGLQSNTDYRFRVCA 1130
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWE--PPPDDGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
SOBP pfam15279
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ...
 50-163 6.29e-03

Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.


Pssm-ID: 464609 [Multi-domain]  Cd Length: 325  Bit Score: 40.18  E-value: 6.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741    50 TIRAEDGTLQCIQGPAEVPMMSPNGSIP-PIHVPPGYISQvieDSTGVRRVVVTPQSPECYPPSYpsAMSPTH--HLPPY 126
Cdd:pfam15279  169 TPRGLLGKPQQHPPPSPLPAFMEPSSMPpPFLRPPPSIPQ---PNSPLSNPMLPGIGPPPKPPRN--LGPPSNpmHRPPF 243

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 300794741   127 LTHHPhfiQNSHTAYYPPVTVPGDMPPQFFPQPHLPP 163
Cdd:pfam15279  244 SPHHP---PPPPTPPGPPPGLPPPPPRGFTPPFGPPF 277
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
540-771 1.95e-19

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 93.91  E-value: 1.95e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  540 NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRplLKG-PVTSHGFSVKWDAPKDNGGSEilkYLLEItdGA 618
Cdd:COG3401   198 DIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTG--LTAtADTPGSVTLSWDPVTESDATG---YRVYR--SN 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  619 SEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCIGTGG-HSQCSESLPVRTLSLAPGqcrPPRVL--GRPKHKEVHLEW 695
Cdd:COG3401   271 SGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPA---APSGLtaTAVGSSSITLSW 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  696 DVPASEGgceVSEYSVE-----MTEPEEVASEVyhgPELECTVGNLLPGTVYRFRVRALNDGG-YGPYSDVSEITTAAGP 769
Cdd:COG3401   348 TASSDAD---VTGYNVYrstsgGGTYTKIAETV---TTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAA 421


                  ..
gi 300794741  770 PG 771
Cdd:COG3401   422 SG 423
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
732-1059 3.58e-17

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 86.59  E-value: 3.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  732 TVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPgqcRAPC---VSFTPDGCVLVGWESPESPGADisEFRLEWG 808
Cdd:COG3401   195 GGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPP---SAPTgltATADTPGSVTLSWDPVTESDAT--GYRVYRS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  809 EDE-ESLELIYHGPDTCFEIRDLLPAAQYCCRLQAFNPAG-AGPYSELVHCQTPASAPDPVSTLCVleeeplSAHLDSpS 886
Cdd:COG3401   270 NSGdGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTA------TAVGSS-S 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  887 VclVLTWEEpcSNGSEIIAYNI----DLGDTCITVG---NTTTHVLKNLLPETTYRIRIQAVNDIGD-GPFSQFIKAKTR 958
Cdd:COG3401   343 I--TLSWTA--SSDADVTGYNVyrstSGGGTYTKIAetvTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTA 418

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  959 PLPPSPPRLECAASGPQSLKLKWGDSNSKIHAAHDMVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQATSe 1038
Cdd:COG3401   419 SAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV- 497

                         330       340
                  ....*....|....*....|.
gi 300794741 1039 AGEGPFSDTYTFSTTKSVPPT 1059
Cdd:COG3401   498 GGSGASSVTNSVSVIGASAAA 518
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
569-951 1.16e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.05  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  569 TTSPDRPGPPTRPLLKGPVTSHGFSVKWDAPKDNGGSEILKYLLEITDGASEAGQWEVAYSGSATEYVFTHLKPGTLYKL 648
Cdd:COG3401   128 ATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYY 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  649 RACCIGTGGHSQCSESLPVRTLSLAPGQcrPPRVLGRPK-HKEVHLEWDvPASEGGceVSEYSVE-MTEPEEVASEVYHG 726
Cdd:COG3401   208 RVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPGSVTLSWD-PVTESD--ATGYRVYrSNSGDGPFTKVATV 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  727 PELECTVGNLLPGTVYRFRVRALN-DGGYGPYSDVSEITTAAGPPGqcrAP----CVSFTPDGCVLvGWESpeSPGADIS 801
Cdd:COG3401   283 TTTSYTDTGLTNGTTYYYRVTAVDaAGNESAPSNVVSVTTDLTPPA---APsgltATAVGSSSITL-SWTA--SSDADVT 356

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  802 EFRLEWGEDEE-SLELIYHGPD-TCFEIRDLLPAAQYCCRLQAFNPAG-AGPYSELVHCQTPASAPDPVSTLcvleeEPL 878
Cdd:COG3401   357 GYNVYRSTSGGgTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTA-----SVD 431

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300794741  879 SAHLDSPSVCLVLTWEEPCSNGSEIIAYNIDLGDTCITVGNTTTHVLKNLLPETTYRIRIQAVNDIGDGPFSQ 951
Cdd:COG3401   432 AVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASS 504
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
450-675 4.17e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 4.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  450 YTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGVTWITLQWSRPEGcspEEVITYTLDIQEDENDNhFHPRY 529
Cdd:COG3401   205 YYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTE---SDATGYRVYRSNSGDGP-FTKVA 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  530 TGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPGPPTrpLLKGPVTSHGF-SVKWDAPKDNGgseI 607
Cdd:COG3401   281 TVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPS--GLTATAVGSSSiTLSWTASSDAD---V 355

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300794741  608 LKYLLEItdGASEAGQWE-VAYSGSATEYVFTHLKPGT--LYKLRAccIGTGG-HSQCSESLPVRTLSLAPG 675
Cdd:COG3401   356 TGYNVYR--STSGGGTYTkIAETVTTTSYTDTGLTPGTtyYYKVTA--VDAAGnESAPSEEVSATTASAASG 423
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 674-765 4.20e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.06  E-value: 4.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  674 PGQCRPPRVLGRPKHkEVHLEWDVPASEGGcEVSEYSVEMTEPEEVASEVY---HGPELECTVGNLLPGTVYRFRVRALN 750
Cdd:cd00063     1 PSPPTNLRVTDVTST-SVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 300794741  751 DGGYGPYSDVSEITT 765
Cdd:cd00063    79 GGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
889-950 1.01e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 1.01e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741   889 LVLTWEEPCSNGSEIIAYNIDLGD--------TCITVGNTTTHVLKNLLPETTYRIRIQAVNDIGDGPFS 950
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYRPknsgepwnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 575-669 1.05e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  575 PGPPTRPLLKgPVTSHGFSVKWDAPKDNGGsEILKYLLEITDGASEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCIG 654
Cdd:cd00063     1 PSPPTNLRVT-DVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 300794741  655 TGGHSQCSESLPVRT 669
Cdd:cd00063    79 GGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 481-570 1.29e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  481 PSAPRLVRAGV---TWITLQWSRPEGcSPEEVITYTLDIQE-DENDNHFHPRYTGEDLTCTVKNLKRSTQYKFRLTASNT 556
Cdd:cd00063     1 PSPPTNLRVTDvtsTSVTLSWTPPED-DGGPITGYVVEYREkGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 300794741  557 EGKSCPSEVLVCTT 570
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
350-615 1.62e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.49  E-value: 1.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  350 PATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITSYLLEWDEGkrnsgfr 429
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNS------- 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  430 qcffGGQKHCKL----------TKLCPAMGYTFRLAARNDIGT-SGYSQEVVCYTLGNIPQMPSAPRLVRAGVTWITLQW 498
Cdd:COG3401   272 ----GDGPFTKVatvtttsytdTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSW 347

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  499 SRPegcSPEEVITYTLDiQEDENDNHFHPRY-TGEDLTCTVKNLKRSTQYKFRLTASNTEG-KSCPSEVLVCTTSPDRPG 576
Cdd:COG3401   348 TAS---SDADVTGYNVY-RSTSGGGTYTKIAeTVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASG 423

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 300794741  577 PPT---RPLLKGPVTSHGFSVKWDAPKDNGGSEILKYLLEIT 615
Cdd:COG3401   424 ESLtasVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTG 465
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
832-1103 1.92e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.11  E-value: 1.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  832 PAAQYCCRLQAFNPAGAGPYSELVHCQTPASAPDPVStlcvleeePLSAHLDSPSVcLVLTWEEpcSNGSEIIAYNIDLG 911
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPT--------GLTATADTPGS-VTLSWDP--VTESDATGYRVYRS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  912 DTC------ITVGNTTTHVLKNLLPETTYRIRIQAVNDIGD-GPFSQFIKAKTRPLPPSP-PRLECAASGPQSLKLKWGD 983
Cdd:COG3401   270 NSGdgpftkVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAApSGLTATAVGSSSITLSWTA 349

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  984 SNSKIHAAHDmVYtlqledRNKRFISIYRG-----PSHTYKVQRLTEFTCYSFRIQATSEAG-EGPFSDTYTF-STTKSV 1056
Cdd:COG3401   350 SSDADVTGYN-VY------RSTSGGGTYTKiaetvTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSAtTASAAS 422

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 300794741 1057 PPTLKAPRVTQLEGNSCEIFWETVPPMKGDPVNYVLQVLVGRESEYK 1103
Cdd:COG3401   423 GESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVP 469
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 382-473 3.05e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 3.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  382 PECPFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEgKRNSGFRQC--FFGGQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 300794741  460 IGTSGYSQEVVCYT 473
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 889-957 7.47e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 7.47e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 300794741  889 LVLTWEEPCSNGSEIIAYNI----DLGDTCITV----GNTTTHVLKNLLPETTYRIRIQAVNDIGDGPFSQFIKAKT 957
Cdd:cd00063    17 VTLSWTPPEDDGGPITGYVVeyreKGSGDWKEVevtpGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
930-1152 1.55e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 65.41  E-value: 1.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  930 PETTYRIRIQAVNDIGDGPFSQFIKAKTRPLPPSPPRL-ECAASGPQSLKLKWgDSNSKIHAAHDMVYtlQLEDRNKRFI 1008
Cdd:COG3401   201 PGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGlTATADTPGSVTLSW-DPVTESDATGYRVY--RSNSGDGPFT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741 1009 SIYRGPSHTYKVQRLTEFTCYSFRIQATSEAG-EGPFSDTYTFSTTKSVPPTLKAPRVTQLEGNSCEIFWETVPPmkGDP 1087
Cdd:COG3401   278 KVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSD--ADV 355

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300794741 1088 VNYVLQVLVGRESEYKQVYKGEEAT-FQISGLQSNTDYRFRVcacrRCVDTsqelSGAFSPSAAFV 1152
Cdd:COG3401   356 TGYNVYRSTSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKV----TAVDA----AGNESAPSEEV 413
fn3 pfam00041
Fibronectin type III domain;
385-466 2.07e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 2.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741   385 PFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEGKRNSGFRQCF-FGGQKHCKLTKLCPAMGYTFRLAARNDIGTS 463
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 300794741   464 GYS 466
Cdd:pfam00041   83 PPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 674-755 4.67e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 4.67e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741    674 PGQCRPPRVLGRPKHkEVHLEWDVPASEGG-CEVSEYSVEMTEPEEVASEVYHGP-ELECTVGNLLPGTVYRFRVRALND 751
Cdd:smart00060    1 PSPPSNLRVTDVTST-SVTLSWEPPPDDGItGYIVGYRVEYREEGSEWKEVNVTPsSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 300794741    752 GGYG 755
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 770-859 5.56e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 5.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  770 PGQCRAPCVSFTPDGCVLVGWESPESPGADISEFRLEWGEDEESLELIY---HGPDTCFEIRDLLPAAQYCCRLQAFNPA 846
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVevtPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 300794741  847 GAGPYSELVHCQT 859
Cdd:cd00063    81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
690-758 6.68e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.65  E-value: 6.68e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 300794741   690 EVHLEWDVPASEGGcEVSEYSVE---MTEPEEVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYS 758
Cdd:pfam00041   15 SLTVSWTPPPDGNG-PITGYEVEyrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 575-659 8.72e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 8.72e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741    575 PGPPTRPLLKgPVTSHGFSVKWDAPK-DNGGSEILKYllEITDGASEAGQWEVAYSGSATEYVFTHLKPGTLYKLRACCI 653
Cdd:smart00060    1 PSPPSNLRVT-DVTSTSVTLSWEPPPdDGITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 300794741    654 GTGGHS 659
Cdd:smart00060   78 NGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 283-377 2.70e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 2.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  283 EKPQVSNIQARAVVLSWAPPVGLPCGPHGglsfpysYEVALSDKGRDGKYKI-IYSGEELECNLKDLRPATDYHVRVYAM 361
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPPEDDGGPITG-------YVVEYREKGSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                          90
                  ....*....|....*.
gi 300794741  362 YNSVKGSCSEPVSFTT 377
Cdd:cd00063    78 NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 864-947 2.79e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 2.79e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741    864 PDPVSTLCVLEEEPLSahldspsvcLVLTWEEPCSNG--SEIIAYNIDLGD------TCITVGNTTTHVLKNLLPETTYR 935
Cdd:smart00060    1 PSPPSNLRVTDVTSTS---------VTLSWEPPPDDGitGYIVGYRVEYREegsewkEVNVTPSSTSYTLTGLKPGTEYE 71

                            90
                    ....*....|..
gi 300794741    936 IRIQAVNDIGDG 947
Cdd:smart00060   72 FRVRAVNGAGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
286-638 6.56e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 56.93  E-value: 6.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  286 QVSNIQARAVVLSWAPPvglpcgPHGGLSfpySYEVALSDKGrDGKYKIIYSGEELECNLKDLRPATDYHVRVYAM-YNS 364
Cdd:COG3401   240 TATADTPGSVTLSWDPV------TESDAT---GYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAG 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  365 VKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGskITSYLLEWDEGKrNSGFRQ-CFFGGQKHCKLTK 443
Cdd:COG3401   310 NESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAD--VTGYNVYRSTSG-GGTYTKiAETVTTTSYTDTG 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  444 LCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGVTWITLQWSRP--EGCSPEEVITYTLDIQEDEN 521
Cdd:COG3401   387 LTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAasAASNPGVSAAVLADGGDTGN 466

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  522 DNHFHPryTGEDLTCTVKNLKRSTQYKFRLTASNTEGKScpsevlVCTTSPDRPGPPTRPLLKGPVTSHGFSVKWDAPKD 601
Cdd:COG3401   467 AVPFTT--TSSTVTATTTDTTTANLSVTTGSLVGGSGAS------SVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTV 538

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 300794741  602 NGGSEILKYLLEITDGASEAGQWEVAYSGSATEYVFT 638
Cdd:COG3401   539 GASTGDVLITDLVSLTTSASSSVSGAGLGSGNLYLIT 575
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 382-463 8.51e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 8.51e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741    382 PECPFPPKLAHRSKSSLTLQWKAPIDNG--SKITSYLLEWDEgKRNSGFRQCFFGGQKHCKLTKLCPAMGYTFRLAARND 459
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYRE-EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 300794741    460 IGTS 463
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
576-649 1.28e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.49  E-value: 1.28e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 300794741   576 GPPTRPLLKgPVTSHGFSVKWDAPKDnGGSEILKYLLEI-TDGASEAGQWEVAySGSATEYVFTHLKPGTLYKLR 649
Cdd:pfam00041    1 SAPSNLTVT-DVTSTSLTVSWTPPPD-GNGPITGYEVEYrPKNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVR 72
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1017-1149 2.10e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 55.39  E-value: 2.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741 1017 TYKVQRLTEFTCYSFRIQATSEAGEGPFSDTYTFsTTKSVPPTlkAP---RVTQLEGNSCEIFWETVPPMkgDPVNYVLQ 1093
Cdd:COG3401   193 VDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSV-TTPTTPPS--APtglTATADTPGSVTLSWDPVTES--DATGYRVY 267

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 300794741 1094 VLVGRESEYKQVYKGEEATFQISGLQSNTDYRFRVCAcrrcVDTSQELSgAFSPSA 1149
Cdd:COG3401   268 RSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTA----VDAAGNES-APSNVV 318
fn3 pfam00041
Fibronectin type III domain;
481-563 2.34e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.72  E-value: 2.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741   481 PSAPRLVRAGVTWITLQWSRPEGCSpEEVITYTLDIQEdENDNHFHPRYT--GEDLTCTVKNLKRSTQYKFRLTASNTEG 558
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGN-GPITGYEVEYRP-KNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 300794741   559 KSCPS 563
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 283-360 3.12e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 3.12e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300794741    283 EKPQVSNIQARAVVLSWAPPVglpcgPHGGLSFPYSYEVALSDKGRDGKyKIIYSGEELECNLKDLRPATDYHVRVYA 360
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPP-----DDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1057-1130 5.14e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.03  E-value: 5.14e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300794741 1057 PPTLKAPRVTQLEGNSCEIFWETVPPMKGDPVNYVLQVLVGRESEYKQVYK--GEEATFQISGLQSNTDYRFRVCA 1130
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 481-560 5.19e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 5.19e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741    481 PSAPRLVRA---GVTWITLQWSRPEGCSPEE-VITYTLDIQEDENDNHFHPRyTGEDLTCTVKNLKRSTQYKFRLTASNT 556
Cdd:smart00060    1 PSPPSNLRVtdvTSTSVTLSWEPPPDDGITGyIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 300794741    557 EGKS 560
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 973-1052 9.50e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.26  E-value: 9.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  973 GPQSLKLKW---GDSNSKIHAahdmvYTLQLEDRNK---RFISIYRGPSHTYKVQRLTEFTCYSFRIQATSEAGEGPFSD 1046
Cdd:cd00063    13 TSTSVTLSWtppEDDGGPITG-----YVVEYREKGSgdwKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                  ....*.
gi 300794741 1047 TYTFST 1052
Cdd:cd00063    88 SVTVTT 93
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
593-770 1.36e-06

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 53.03  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  593 SVKWDAPKDNGGseilkYLLEITDGAseaGQWEVAYSGSATEYVFTHLKPGTlYKLRACCIGTGGHSQCSESLPVRTLS- 671
Cdd:COG4733   555 TVSWDAPAGAVA-----YEVEWRRDD---GNWVSVPRTSGTSFEVPGIYAGD-YEVRVRAINALGVSSAWAASSETTVTg 625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741  672 -LAPgqcrPPRVLG---RPKHKEVHLEWDVPAsegGCEVSEYSVEM---TEPEEVASEVYHGPELECTVGNLLPGTVYRF 744
Cdd:COG4733   626 kTAP----PPAPTGltaTGGLGGITLSWSFPV---DADTLRTEIRYsttGDWASATVAQALYPGNTYTLAGLKAGQTYYY 698

                         170       180
                  ....*....|....*....|....*..
gi 300794741  745 RVRALNDGG-YGPYSDVSEITTAAGPP 770
Cdd:COG4733   699 RARAVDRSGnVSAWWVSGQASADAAGI 725
fn3 pfam00041
Fibronectin type III domain;
786-852 1.75e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 1.75e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741   786 VLVGWESPESPGADISEFRLEW---GEDEESLELIYHGPDTCFEIRDLLPAAQYCCRLQAFNPAGAGPYS 852
Cdd:pfam00041   16 LTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
285-360 2.22e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 2.22e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300794741   285 PQVSNIQARAVVLSWAPPvglpcgPHGGLSFpYSYEVALS--DKGRDGKYKIIySGEELECNLKDLRPATDYHVRVYA 360
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPP------PDGNGPI-TGYEVEYRpkNSGEPWNEITV-PGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 770-849 6.11e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 6.11e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741    770 PGQCRAPCVSFTPDGCVLVGWESPESPGAD--ISEFRLEWGE-DEESLELIYHGPDTCFEIRDLLPAAQYCCRLQAFNPA 846
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREeGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 300794741    847 GAG 849
Cdd:smart00060   81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
1057-1130 3.46e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 3.46e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 300794741  1057 PPTlkAPRVTQLEGNSCEIFWETVPPMKGDPVNYVLQVLVGRESEYKQVY--KGEEATFQISGLQSNTDYRFRVCA 1130
Cdd:pfam00041    2 APS--NLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1057-1130 5.26e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 5.26e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 300794741   1057 PPTLKAPRVTQLEGNSCEIFWEtvPPMKGDPVNYVLQVLV---GRESEYKQVYKGEEAT-FQISGLQSNTDYRFRVCA 1130
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWE--PPPDDGITGYIVGYRVeyrEEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRA 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 971-1042 3.88e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 3.88e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 300794741    971 ASGPQSLKLKWGDSNSKIHAAHDMVYTLQLEDRNKRFISIYRGPSHT-YKVQRLTEFTCYSFRIQATSEAGEG 1042
Cdd:smart00060   11 DVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGAGEG 83
SOBP pfam15279
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ...
 50-163 6.29e-03

Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.


Pssm-ID: 464609 [Multi-domain]  Cd Length: 325  Bit Score: 40.18  E-value: 6.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 300794741    50 TIRAEDGTLQCIQGPAEVPMMSPNGSIP-PIHVPPGYISQvieDSTGVRRVVVTPQSPECYPPSYpsAMSPTH--HLPPY 126
Cdd:pfam15279  169 TPRGLLGKPQQHPPPSPLPAFMEPSSMPpPFLRPPPSIPQ---PNSPLSNPMLPGIGPPPKPPRN--LGPPSNpmHRPPF 243

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 300794741   127 LTHHPhfiQNSHTAYYPPVTVPGDMPPQFFPQPHLPP 163
Cdd:pfam15279  244 SPHHP---PPPPTPPGPPPGLPPPPPRGFTPPFGPPF 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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