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Conserved domains on  [gi|312596910|ref|NP_001186102|]
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target of rapamycin complex subunit LST8 isoform a [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-320 7.68e-60

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 197.06  E-value: 7.68e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSnnPNPIISYDGVNKNI 88
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLWDLAT--GKLLRTLTGHSGAV 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  89 ASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP 167
Cdd:COG2319  166 TSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910 168 EPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:COG2319  244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312596910 248 RTSNFSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320
Cdd:COG2319  316 DLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-320 7.68e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 197.06  E-value: 7.68e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSnnPNPIISYDGVNKNI 88
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLWDLAT--GKLLRTLTGHSGAV 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  89 ASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP 167
Cdd:COG2319  166 TSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910 168 EPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:COG2319  244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312596910 248 RTSNFSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320
Cdd:COG2319  316 DLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-297 6.73e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 154.80  E-value: 6.73e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPnpIISYDGVNKNIASVG 92
Cdd:cd00200   23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKtIRLWDLETGEC--VRTLTGHTSYVSSVA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  93 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171
Cdd:cd00200  101 FSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGigDEVTQLIpktkipAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:cd00200  179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG--KCLGTLR------GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 312596910 252 FSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLW 297
Cdd:cd00200  251 GECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 212-247 7.81e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 7.81e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 312596910   212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
212-247 3.78e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.78e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 312596910  212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 10-114 1.76e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.15  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQdSQVNALEVTPD--RSMIAAAGYQHIRMYDLnsNNPN-PIISYDGVNK 86
Cdd:PLN00181 586 ADPTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQFPSEsgRSLAFGSADHKVYYYDL--RNPKlPLCTMIGHSK 662

                         90       100
                 ....*....|....*....|....*...
gi 312596910  87 NIASVGFhEDGRWMYTGGEDCTARIWDL 114
Cdd:PLN00181 663 TVSYVRF-VDSSTLVSSSTDNTLKLWDL 689
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-320 7.68e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 197.06  E-value: 7.68e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSnnPNPIISYDGVNKNI 88
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLWDLAT--GKLLRTLTGHSGAV 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  89 ASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP 167
Cdd:COG2319  166 TSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910 168 EPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:COG2319  244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312596910 248 RTSNFSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320
Cdd:COG2319  316 DLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
14-297 4.81e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.64  E-value: 4.81e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPnpIISYDGVNKNIASVG 92
Cdd:COG2319  134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGtVRLWDLATGKL--LRTLTGHTGAVRSVA 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  93 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATG--KLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:COG2319  290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATG------KLL--RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 312596910 252 FSLMTELsiksgnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLW 297
Cdd:COG2319  362 GELLRTL--------TGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-297 6.73e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 154.80  E-value: 6.73e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPnpIISYDGVNKNIASVG 92
Cdd:cd00200   23 LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKtIRLWDLETGEC--VRTLTGHTSYVSSVA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  93 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQ-VNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171
Cdd:cd00200  101 FSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGigDEVTQLIpktkipAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:cd00200  179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG--KCLGTLR------GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 312596910 252 FSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLW 297
Cdd:cd00200  251 GECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
14-251 5.39e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.06  E-value: 5.39e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  14 ILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSnnPNPIISYDGVNKNIASVG 92
Cdd:COG2319  176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGtVRLWDLAT--GKLLRTLTGHSGSVRSVA 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  93 FHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171
Cdd:COG2319  254 FSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGhSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIgdevtqliPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--------LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
8-320 9.76e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.29  E-value: 9.76e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910   8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMyDLNSNNPNPIISYDGVNKN 87
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLL-LLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  88 IASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQcQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIP 167
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLL-RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910 168 EPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtQLIpkTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG------KLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 312596910 248 RTSNFSLMTELsiksgnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAF 320
Cdd:COG2319  232 DLATGKLLRTL--------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-248 3.68e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.47  E-value: 3.68e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  15 LATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQH-IRMYDLNSNNPnpIISYDGVNKNIASVGF 93
Cdd:cd00200   66 LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKtIKVWDVETGKC--LTTLRGHTDWVNSVAF 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  94 HEDGRWMYTGGEDCTARIWDLRSrnLQCQRIFQV-NAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVS 172
Cdd:cd00200  144 SPDGTFVASSSQDGTIKLWDLRT--GKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 312596910 173 ITSAHIDPDASYMAAVNSTGNCYVWNLTGGigdevtqlIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWR 248
Cdd:cd00200  222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTG--------ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
92-321 7.44e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 7.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  92 GFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVcLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEV 171
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLA-ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIgdevtqliPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGL--------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910 252 FSLMTELSiksgnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 321
Cdd:COG2319  152 GKLLRTLT--------GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-156 2.54e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 2.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910   8 VGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPD-RSMIAAAGYQHIRMYDLNSnnPNPIISYDGVNK 86
Cdd:cd00200  143 FSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDgEKLLSSSSDGTIKLWDLST--GKCLGTLRGHEN 220

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  87 NIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLqCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWD 156
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-323 1.08e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 1.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910 172 SITSAHIDPDASYMAAVNSTGNCYVWNLTGGIgdevtqliPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 251
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--------LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 312596910 252 FSLMTELsiksgnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 323
Cdd:cd00200   83 GECVRTL--------TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 216-323 4.14e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 4.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910 216 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGnpgessrgWMWGCAFSGDSQYIVTASSDNLAR 295
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--------PVRDVAASADGTYLASGSSDKTIR 76

                         90       100
                 ....*....|....*....|....*...
gi 312596910 296 LWCVETGEIKREYGGHQKAVVCLAFNDS 323
Cdd:cd00200   77 LWDLETGECVRTLTGHTSYVSSVAFSPD 104
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 212-247 7.81e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 7.81e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 312596910   212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
212-247 3.78e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.78e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 312596910  212 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 247
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
76-113 7.23e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 7.23e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 312596910   76 NPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD 113
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 74-113 1.16e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.16e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 312596910    74 NPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWD 113
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 10-114 1.76e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.15  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312596910  10 SDPVILATAGYDHTVRFWQAHSGICTRTVQHQdSQVNALEVTPD--RSMIAAAGYQHIRMYDLnsNNPN-PIISYDGVNK 86
Cdd:PLN00181 586 ADPTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQFPSEsgRSLAFGSADHKVYYYDL--RNPKlPLCTMIGHSK 662

                         90       100
                 ....*....|....*....|....*...
gi 312596910  87 NIASVGFhEDGRWMYTGGEDCTARIWDL 114
Cdd:PLN00181 663 TVSYVRF-VDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 270-297 5.25e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.21  E-value: 5.25e-03
                           10        20
                   ....*....|....*....|....*...
gi 312596910   270 RGWMWGCAFSGDSQYIVTASSDNLARLW 297
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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