NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|320544352|ref|NP_001189004|]
View 

matrix metalloproteinase 1, isoform J [Drosophila melanogaster]

Protein Classification

matrix metalloproteinase( domain architecture ID 12021147)

matrix metalloproteinase is an M10A family metallopeptidase with a C-terminal hemopexin repeat-containing domain, such as stromelysin-1 (matrix metalloproteinase-3), which can degrade fibronectin, laminin, type I, III, IV, and V gelatins, collagens III, IV, X, and IX, as well as cartilage proteoglycans

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 115-268 2.73e-78

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


:

Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 242.14  E-value: 2.73e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352  115 RWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFP 194
Cdd:pfam00413   1 KWRKKNLTYRILNYTPDLPRAEVRRAIRRAFKVWSEVTPLTFTEVSTGEADIMIGFGRGDHGDGYPFDGPGGVLAHAFFP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320544352  195 --VFGGDAHFDDAELWTIGS--PRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPV-FKLDEDDKAAIQSLYG 268
Cdd:pfam00413  81 gpGLGGDIHFDDDETWTVGSdpPHGINLFLVAAHEIGHALGLGHSSDPGAIMYPTYSPLDSKkFRLSQDDIKGIQQLYG 159
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 298-493 1.79e-60

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 197.15  E-value: 1.79e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352 298 SICKDSKVDTLFNSaQGETYAFKGDKYYKLTTDSVEeGYPQLISKGWPGLPGNIDAAFTYKN-GKTYFFKGTQYWRYQGR 376
Cdd:cd00094    2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPGKPP-GSPFLISSFWPSLPSPVDAAFERPDtGKIYFFKGDKYWVYTGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352 377 QMDGVYPKEISE-GFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNWEGVPNNLDAALKYTNG 455
Cdd:cd00094   80 NLEPGYPKPISDlGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIETDFPGVPDKVDAAFRWLDG 159

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 320544352 456 YTYFFKGDKYYRFHDARFAVDsatPPFPRPTAHWWFGC 493
Cdd:cd00094  160 YYYFFKGDQYWRFDPRSKEVR---VGYPLKISSDWLGC 194
PG_binding_1 pfam01471
Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This ...
 32-88 5.71e-09

Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This domain is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.


:

Pssm-ID: 460223 [Multi-domain]  Cd Length: 57  Bit Score: 52.13  E-value: 5.71e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 320544352   32 QAEIYLSQFGYLPASArnpasSGLHDQRTwVSAIEEFQSFAGLNITGELDAETMKLM 88
Cdd:pfam01471   7 ELQRYLNRLGYYPGPV-----DGYFGPST-EAAVKAFQRAFGLPVDGIVDPETLAAL 57
 
Name Accession Description Interval E-value
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 115-268 2.73e-78

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 242.14  E-value: 2.73e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352  115 RWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFP 194
Cdd:pfam00413   1 KWRKKNLTYRILNYTPDLPRAEVRRAIRRAFKVWSEVTPLTFTEVSTGEADIMIGFGRGDHGDGYPFDGPGGVLAHAFFP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320544352  195 --VFGGDAHFDDAELWTIGS--PRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPV-FKLDEDDKAAIQSLYG 268
Cdd:pfam00413  81 gpGLGGDIHFDDDETWTVGSdpPHGINLFLVAAHEIGHALGLGHSSDPGAIMYPTYSPLDSKkFRLSQDDIKGIQQLYG 159
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 115-268 1.09e-77

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 240.57  E-value: 1.09e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352 115 RWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSG-PVHIEIKFVESEHGDGDAFDGQGGTLAHAFF 193
Cdd:cd04278    1 KWSKTNLTYRILNYPPDLPRDDVRRAIARAFRVWSDVTPLTFREVTSGqEADIRISFARGNHGDGYPFDGPGGTLAHAFF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320544352 194 PVF-GGDAHFDDAELWTIGS-PRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPVFKLDEDDKAAIQSLYG 268
Cdd:cd04278   81 PGGiGGDIHFDDDEQWTLGSdSGGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVPKFKLSQDDIRGIQALYG 157
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 298-493 1.79e-60

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 197.15  E-value: 1.79e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352 298 SICKDSKVDTLFNSaQGETYAFKGDKYYKLTTDSVEeGYPQLISKGWPGLPGNIDAAFTYKN-GKTYFFKGTQYWRYQGR 376
Cdd:cd00094    2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPGKPP-GSPFLISSFWPSLPSPVDAAFERPDtGKIYFFKGDKYWVYTGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352 377 QMDGVYPKEISE-GFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNWEGVPNNLDAALKYTNG 455
Cdd:cd00094   80 NLEPGYPKPISDlGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIETDFPGVPDKVDAAFRWLDG 159

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 320544352 456 YTYFFKGDKYYRFHDARFAVDsatPPFPRPTAHWWFGC 493
Cdd:cd00094  160 YYYFFKGDQYWRFDPRSKEVR---VGYPLKISSDWLGC 194
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 115-268 3.07e-24

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 98.19  E-value: 3.07e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352   115 RWRVKNLTYKISKYPkrLKRvDVDAEIGRAFAVWSEDTDLTFTRKTSGPVhIEIKFVESEHGdgdafdgqgGTLAHAFFP 194
Cdd:smart00235   4 KWPKGTVPYVIDSSS--LSP-EEREAIAKALAEWSDVTCIRFVERTGTAD-IYISFGSGDSG---------CTLSHAGRP 70

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320544352   195 vfGGDAHFDDaELWTIGsprgtnlFQVAAHEFGHSLGLSHSDQSSA---LMAPFYRG-FEPVFKLDEDDKAAIQSLYG 268
Cdd:smart00235  71 --GGDQHLSL-GNGCIN-------TGVAAHELGHALGLYHEQSRSDrdnYMYINYTNiDTRNFDLSEDDSLGIPYDYG 138
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 351-394 1.12e-14

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 68.04  E-value: 1.12e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 320544352   351 IDAAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIP 394
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 351-394 2.28e-12

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 61.43  E-value: 2.28e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 320544352  351 IDAAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISEgFTGIP 394
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRVEPGYPKLISD-FPGLP 43
PG_binding_1 pfam01471
Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This ...
 32-88 5.71e-09

Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This domain is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.


Pssm-ID: 460223 [Multi-domain]  Cd Length: 57  Bit Score: 52.13  E-value: 5.71e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 320544352   32 QAEIYLSQFGYLPASArnpasSGLHDQRTwVSAIEEFQSFAGLNITGELDAETMKLM 88
Cdd:pfam01471   7 ELQRYLNRLGYYPGPV-----DGYFGPST-EAAVKAFQRAFGLPVDGIVDPETLAAL 57
 
Name Accession Description Interval E-value
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 115-268 2.73e-78

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 242.14  E-value: 2.73e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352  115 RWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFP 194
Cdd:pfam00413   1 KWRKKNLTYRILNYTPDLPRAEVRRAIRRAFKVWSEVTPLTFTEVSTGEADIMIGFGRGDHGDGYPFDGPGGVLAHAFFP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 320544352  195 --VFGGDAHFDDAELWTIGS--PRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPV-FKLDEDDKAAIQSLYG 268
Cdd:pfam00413  81 gpGLGGDIHFDDDETWTVGSdpPHGINLFLVAAHEIGHALGLGHSSDPGAIMYPTYSPLDSKkFRLSQDDIKGIQQLYG 159
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 115-268 1.09e-77

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 240.57  E-value: 1.09e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352 115 RWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSG-PVHIEIKFVESEHGDGDAFDGQGGTLAHAFF 193
Cdd:cd04278    1 KWSKTNLTYRILNYPPDLPRDDVRRAIARAFRVWSDVTPLTFREVTSGqEADIRISFARGNHGDGYPFDGPGGTLAHAFF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320544352 194 PVF-GGDAHFDDAELWTIGS-PRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRGFEPVFKLDEDDKAAIQSLYG 268
Cdd:cd04278   81 PGGiGGDIHFDDDEQWTLGSdSGGTDLFSVAAHEIGHALGLGHSSDPDSIMYPYYQGPVPKFKLSQDDIRGIQALYG 157
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 298-493 1.79e-60

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 197.15  E-value: 1.79e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352 298 SICKDSKVDTLFNSaQGETYAFKGDKYYKLTTDSVEeGYPQLISKGWPGLPGNIDAAFTYKN-GKTYFFKGTQYWRYQGR 376
Cdd:cd00094    2 DACDPLSFDAVTTL-RGELYFFKGRYFWRLSPGKPP-GSPFLISSFWPSLPSPVDAAFERPDtGKIYFFKGDKYWVYTGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352 377 QMDGVYPKEISE-GFTGIPDHLDAAMVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNWEGVPNNLDAALKYTNG 455
Cdd:cd00094   80 NLEPGYPKPISDlGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKLIETDFPGVPDKVDAAFRWLDG 159

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 320544352 456 YTYFFKGDKYYRFHDARFAVDsatPPFPRPTAHWWFGC 493
Cdd:cd00094  160 YYYFFKGDQYWRFDPRSKEVR---VGYPLKISSDWLGC 194
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 115-268 3.07e-24

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 98.19  E-value: 3.07e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352   115 RWRVKNLTYKISKYPkrLKRvDVDAEIGRAFAVWSEDTDLTFTRKTSGPVhIEIKFVESEHGdgdafdgqgGTLAHAFFP 194
Cdd:smart00235   4 KWPKGTVPYVIDSSS--LSP-EEREAIAKALAEWSDVTCIRFVERTGTAD-IYISFGSGDSG---------CTLSHAGRP 70

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 320544352   195 vfGGDAHFDDaELWTIGsprgtnlFQVAAHEFGHSLGLSHSDQSSA---LMAPFYRG-FEPVFKLDEDDKAAIQSLYG 268
Cdd:smart00235  71 --GGDQHLSL-GNGCIN-------TGVAAHELGHALGLYHEQSRSDrdnYMYINYTNiDTRNFDLSEDDSLGIPYDYG 138
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 351-394 1.12e-14

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 68.04  E-value: 1.12e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 320544352   351 IDAAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIP 394
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 351-394 2.28e-12

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 61.43  E-value: 2.28e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 320544352  351 IDAAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISEgFTGIP 394
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRVEPGYPKLISD-FPGLP 43
ZnMc_MMP_like_1 cd04279
Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and ...
 143-268 2.73e-10

Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239806 [Multi-domain]  Cd Length: 156  Bit Score: 59.01  E-value: 2.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352 143 RAFAVWSEDTDLTF----TRKTSGpvHIEIKFVESEHGDGdafdgQGGTLAHAFFPVFGGDA----HFDDAELWTIGSPR 214
Cdd:cd04279   28 QAAAEWENVGPLKFvynpEEDNDA--DIVIFFDRPPPVGG-----AGGGLARAGFPLISDGNrklfNRTDINLGPGQPRG 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 320544352 215 GTNLFQVAAHEFGHSLGLSH-SDQSSALMAPFY-RGFEPVFKLDEDDKAAIQSLYG 268
Cdd:cd04279  101 AENLQAIALHELGHALGLWHhSDRPEDAMYPSQgQGPDGNPTLSARDVATLKRLYG 156
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 397-444 3.21e-10

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 55.27  E-value: 3.21e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 320544352  397 LDAAMVWGgNGKIYFFKGSKFWRFDPAKRPPVkasYPKPISNWEGVPN 444
Cdd:pfam00045   1 IDAAFEDR-DGKTYFFKGRKYWRFDPQRVEPG---YPKLISDFPGLPC 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 305-349 5.88e-10

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 54.56  E-value: 5.88e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 320544352   305 VDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPG 349
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLPC 45
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
 141-268 1.61e-09

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 57.43  E-value: 1.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352 141 IGRAFAVWSEDTDLTFTRkTSGPVHIEIKFVESehgdgdaFDGQGGTLAHAFFP------VFGGDAHFDDAELWTIGSPr 214
Cdd:cd04277   39 ARDALEAWEDVADIDFVE-VSDNSGADIRFGNS-------SDPDGNTAGYAYYPgsgsgtAYGGDIWFNSSYDTNSDSP- 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352 215 GTNLFQVAAHEFGHSLGLSHSDQSSA----------------LMApfYRgFEPVFKLDED----------DKAAIQSLYG 268
Cdd:cd04277  110 GSYGYQTIIHEIGHALGLEHPGDYNGgdpvpptyaldsreytVMS--YN-SGYGNGASAGggypqtpmllDIAALQYLYG 186
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 397-443 1.88e-09

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 53.02  E-value: 1.88e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 320544352   397 LDAAMVWGgNGKIYFFKGSKFWRFDPAKRPPVkasYPKPISN-WEGVP 443
Cdd:smart00120   1 IDAAFELR-DGKTYFFKGDKYWRFDPKRVDPG---YPKLISSfFPGLP 44
PG_binding_1 pfam01471
Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This ...
 32-88 5.71e-09

Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This domain is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.


Pssm-ID: 460223 [Multi-domain]  Cd Length: 57  Bit Score: 52.13  E-value: 5.71e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 320544352   32 QAEIYLSQFGYLPASArnpasSGLHDQRTwVSAIEEFQSFAGLNITGELDAETMKLM 88
Cdd:pfam01471   7 ELQRYLNRLGYYPGPV-----DGYFGPST-EAAVKAFQRAFGLPVDGIVDPETLAAL 57
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 168-267 3.47e-08

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 52.91  E-value: 3.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352 168 IKFVES--EHGDGD------AFDGQGGTLAHAFFPV----FGGDAHFDDAELWTIgsprgtNLFQVAAHEFGHSLGLSHS 235
Cdd:cd00203   40 IRFVLVgvEIDKADiailvtRQDFDGGTGGWAYLGRvcdsLRGVGVLQDNQSGTK------EGAQTIAHELGHALGFYHD 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 320544352 236 --------------------DQSSALMAPFYRGFEPV--FKLDEDDKAAIQSLY 267
Cdd:cd00203  114 hdrkdrddyptiddtlnaedDDYYSVMSYTKGSFSDGqrKDFSQCDIDQINKLY 167
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 446-492 1.59e-07

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 47.62  E-value: 1.59e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 320544352   446 LDAALKYTNGYTYFFKGDKYYRFHDARfaVDsatPPFPRPTAHWWFG 492
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKR--VD---PGYPKLISSFFPG 42
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 305-348 1.97e-07

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 47.56  E-value: 1.97e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 320544352  305 VDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQLISKgWPGLP 348
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRVEPGYPKLISD-FPGLP 43
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 446-493 2.60e-06

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 44.09  E-value: 2.60e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 320544352  446 LDAALKYTNGYTYFFKGDKYYRFHDARfavdsATPPFPRPTAHW-WFGC 493
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQR-----VEPGYPKLISDFpGLPC 44
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 118-267 4.44e-04

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 40.94  E-value: 4.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352 118 VKNLTYKIS-KYPKRLKRVdvdaeIGRAFAVWSEDTDLTFT-RKTSGPVHIEIKFVESEHGDGdafdgQGGTLAHAFFPV 195
Cdd:cd04268    1 KKPITYYIDdSVPDKLRAA-----ILDAIEAWNKAFAIGFKnANDVDPADIRYSVIRWIPYND-----GTWSYGPSQVDP 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320544352 196 FGGDAHFDDAELWTIGSP-RGTNLFQVAAHEFGHSLGLSHSDQSSAL----------------MAPFYRGFEPVF----- 253
Cdd:cd04268   71 LTGEILLARVYLYSSFVEySGARLRNTAEHELGHALGLRHNFAASDRddnvdllaekgdtssvMDYAPSNFSIQLgdgqk 150

                        170
                 ....*....|....*
gi 320544352 254 -KLDEDDKAAIQSLY 267
Cdd:cd04268  151 yTIGPYDIAAIKKLY 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH