|
Name |
Accession |
Description |
Interval |
E-value |
| Sin3 super family |
cl35027 |
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]; |
13-660 |
4.82e-89 |
|
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
The actual alignment was detected with superfamily member COG5602:
Pssm-ID: 227889 [Multi-domain] Cd Length: 1163 Bit Score: 314.93 E-value: 4.82e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 13 SQFRRPLGSSRGQLCGQSPVHGSGDTEEEEEGGSRRVS-QKLTTNDALSYLREVKEMFQDQREKYDRFLEVMKDFKAQRT 91
Cdd:COG5602 85 EDVEQILSSLAGDNPDPSTDHGSASNQNMERSPPPRIPyRPLDVSDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKSQAI 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 92 DTGGVIARVKELFKGHNNLIYGFNTFLPKGYEITLIEED----------------------------------------- 130
Cdd:COG5602 165 DTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLPQpngsrlhvttpqgplssppvqssyyvapcnhdqrtshptlp 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 131 ---------------DALPKKTVEFEQAINFVNKIKMRFKHDEHVYKSFLEILNMYRKENKEIKEVYNEVSILFQGHLDL 195
Cdd:COG5602 245 sdsqpepsapshmpsDARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSIQEVYARVTKLFAEAPDL 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 196 LEQFTRFLPASlpSHSAAQhSRSQAQQYSDRGSDPPLLHQMQVEKERRRERavalrgdysverydlnddktmvkiQREQR 275
Cdd:COG5602 325 LEEFKEFLPDS--SVSAEQ-STANAQKPSKRLPPIGSFSLPTAAPEQNRPS------------------------LLWES 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 276 KRLDKENRARRGRDLDDREagqdnLHHFPEKRKSSrraealeaYSGMYKQAFVFCEKVKDRLCSQDDYQTFLKCLNIFSN 355
Cdd:COG5602 378 PRSISNISRYRADLLTSFS-----RNFVPIRIHMP--------ISHLSNESEDFFERIKQYLKDKNLYHEFLKLLNLYSQ 444
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 356 GIIQRKDLQNLVSDLLGKFPDLMDEFNQFFERCESItdgfqrlagvmskklfssEEQLSRPMKveekesehkpeleavke 435
Cdd:COG5602 445 KIIDKNDLVERLFAFLGSNEELIRWFKAFINYSEPE------------------KEPLRETRK----------------- 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 436 teqckkeymgksiqelDLSDCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSV-TSGSEDYSFKHMRRNQYEESL 514
Cdd:COG5602 490 ----------------DLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHpTWASEDSGFIAHRKNQYEEAL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 515 FRCEDDRFELDMLLESVSSAARSAESLLNIITEKKISFSGSFRIEDHFTALNLRCIER----LYG-DHGLDVIDILNKNP 589
Cdd:COG5602 554 FKIEEERYEYDRHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKvikkVYDkEHAPEILEALLKKP 633
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185014 590 ATALPVILTRLKQKQGEWKKCRDDFDKVWANVYAKNHYKSLDHRSFYFKQQDSKNLSAKSLLAEIKELKEK 660
Cdd:COG5602 634 HVTIPIVLKRLKMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEIDDRSQA 704
|
|
| Sin3a_C |
pfam16879 |
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at ... |
1088-1331 |
4.85e-52 |
|
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at the C-terminus of the co-repressor Sin3a, and downstream of family Sin3_corepress, pfam08295.
:
Pssm-ID: 465294 Cd Length: 281 Bit Score: 184.73 E-value: 4.85e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1088 FYGNDDFYVLFRLHQILYERILYAKRNCS--GGELKSKN-------------------LKDTNAGDPYARFMRVLYGLLD 1146
Cdd:pfam16879 1 FFANTTIYVFFRLFQILYERLLKIKQAEEevAEEIKRRKankpakdlgliskeledfgLDLSDPEDYYPQLLELCERLID 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1147 GSAENTKFEDECRAIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYY-ENVRVLV-H 1224
Cdd:pfam16879 81 GEIDQSQFEDSLRQMYGNKAYKLYTIDKLIQALVKQLQTIVSDSKSQELLELFEKERSKEETTAQDEILYrKQAEKLLgK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1225 EENIYRLECSSLPSRLSIQLMDNIIEKPEAYAVSMDPTFASYMQ-------TELLSVSSGKKeeghdIVLQRNLTGL--- 1294
Cdd:pfam16879 161 DENLFRIEWNPQSKTVTIQLLDKDDLTFDDDELTAEERWQYYVSsyvlshpTEGVPRSKLRK-----PFLKRNLKAEree 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 334185014 1295 ---------YDLCKAMEGVEVVNGLECKMSCSSYKIAYVLDTEDYF 1331
Cdd:pfam16879 236 eedeeeepkADAEEPEGPLEFESGLEIRICLNSYKLFYVPGTEDYF 281
|
|
| 2A1904 super family |
cl36772 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
919-1060 |
2.16e-03 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
The actual alignment was detected with superfamily member TIGR00927:
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 42.68 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 919 LANGLRSDS-SKGTRNSDDPEGPSRNEKEEGELS-----PNGDFEDNFGVYKDHGVKSTSKPEN-SAEAEVEADAEVENE 991
Cdd:TIGR00927 630 LSKGDVAEAeHTGERTGEEGERPTEAEGENGEESggeaeQEGETETKGENESEGEIPAERKGEQeGEGEIEAKEADHKGE 709
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334185014 992 DDADDVDSENASEASGTESGGDVCSQDEDREEENGEHDEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1060
Cdd:TIGR00927 710 TEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDE 778
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Sin3 |
COG5602 |
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]; |
13-660 |
4.82e-89 |
|
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
Pssm-ID: 227889 [Multi-domain] Cd Length: 1163 Bit Score: 314.93 E-value: 4.82e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 13 SQFRRPLGSSRGQLCGQSPVHGSGDTEEEEEGGSRRVS-QKLTTNDALSYLREVKEMFQDQREKYDRFLEVMKDFKAQRT 91
Cdd:COG5602 85 EDVEQILSSLAGDNPDPSTDHGSASNQNMERSPPPRIPyRPLDVSDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKSQAI 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 92 DTGGVIARVKELFKGHNNLIYGFNTFLPKGYEITLIEED----------------------------------------- 130
Cdd:COG5602 165 DTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLPQpngsrlhvttpqgplssppvqssyyvapcnhdqrtshptlp 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 131 ---------------DALPKKTVEFEQAINFVNKIKMRFKHDEHVYKSFLEILNMYRKENKEIKEVYNEVSILFQGHLDL 195
Cdd:COG5602 245 sdsqpepsapshmpsDARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSIQEVYARVTKLFAEAPDL 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 196 LEQFTRFLPASlpSHSAAQhSRSQAQQYSDRGSDPPLLHQMQVEKERRRERavalrgdysverydlnddktmvkiQREQR 275
Cdd:COG5602 325 LEEFKEFLPDS--SVSAEQ-STANAQKPSKRLPPIGSFSLPTAAPEQNRPS------------------------LLWES 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 276 KRLDKENRARRGRDLDDREagqdnLHHFPEKRKSSrraealeaYSGMYKQAFVFCEKVKDRLCSQDDYQTFLKCLNIFSN 355
Cdd:COG5602 378 PRSISNISRYRADLLTSFS-----RNFVPIRIHMP--------ISHLSNESEDFFERIKQYLKDKNLYHEFLKLLNLYSQ 444
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 356 GIIQRKDLQNLVSDLLGKFPDLMDEFNQFFERCESItdgfqrlagvmskklfssEEQLSRPMKveekesehkpeleavke 435
Cdd:COG5602 445 KIIDKNDLVERLFAFLGSNEELIRWFKAFINYSEPE------------------KEPLRETRK----------------- 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 436 teqckkeymgksiqelDLSDCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSV-TSGSEDYSFKHMRRNQYEESL 514
Cdd:COG5602 490 ----------------DLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHpTWASEDSGFIAHRKNQYEEAL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 515 FRCEDDRFELDMLLESVSSAARSAESLLNIITEKKISFSGSFRIEDHFTALNLRCIER----LYG-DHGLDVIDILNKNP 589
Cdd:COG5602 554 FKIEEERYEYDRHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKvikkVYDkEHAPEILEALLKKP 633
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185014 590 ATALPVILTRLKQKQGEWKKCRDDFDKVWANVYAKNHYKSLDHRSFYFKQQDSKNLSAKSLLAEIKELKEK 660
Cdd:COG5602 634 HVTIPIVLKRLKMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEIDDRSQA 704
|
|
| Sin3a_C |
pfam16879 |
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at ... |
1088-1331 |
4.85e-52 |
|
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at the C-terminus of the co-repressor Sin3a, and downstream of family Sin3_corepress, pfam08295.
Pssm-ID: 465294 Cd Length: 281 Bit Score: 184.73 E-value: 4.85e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1088 FYGNDDFYVLFRLHQILYERILYAKRNCS--GGELKSKN-------------------LKDTNAGDPYARFMRVLYGLLD 1146
Cdd:pfam16879 1 FFANTTIYVFFRLFQILYERLLKIKQAEEevAEEIKRRKankpakdlgliskeledfgLDLSDPEDYYPQLLELCERLID 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1147 GSAENTKFEDECRAIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYY-ENVRVLV-H 1224
Cdd:pfam16879 81 GEIDQSQFEDSLRQMYGNKAYKLYTIDKLIQALVKQLQTIVSDSKSQELLELFEKERSKEETTAQDEILYrKQAEKLLgK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1225 EENIYRLECSSLPSRLSIQLMDNIIEKPEAYAVSMDPTFASYMQ-------TELLSVSSGKKeeghdIVLQRNLTGL--- 1294
Cdd:pfam16879 161 DENLFRIEWNPQSKTVTIQLLDKDDLTFDDDELTAEERWQYYVSsyvlshpTEGVPRSKLRK-----PFLKRNLKAEree 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 334185014 1295 ---------YDLCKAMEGVEVVNGLECKMSCSSYKIAYVLDTEDYF 1331
Cdd:pfam16879 236 eedeeeepkADAEEPEGPLEFESGLEIRICLNSYKLFYVPGTEDYF 281
|
|
| HDAC_interact |
smart00761 |
Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It ... |
455-551 |
5.38e-45 |
|
Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.
Pssm-ID: 214808 [Multi-domain] Cd Length: 102 Bit Score: 157.47 E-value: 5.38e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 455 DCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSVTSG-SEDYSFKHMRRNQYEESLFRCEDDRFELDMLLESVSS 533
Cdd:smart00761 1 NCERCGPSYRLLPKSEKQPKCSGRDELCKEVLNDTWVSHPTWaSEDSGFVAHRKNQYEEALFRCEDERFELDMVIESNSS 80
|
90
....*....|....*...
gi 334185014 534 AARSAESLLNIITEKKIS 551
Cdd:smart00761 81 TIKLLEEILNKIEDMSDE 98
|
|
| Sin3_corepress |
pfam08295 |
Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms ... |
457-550 |
1.61e-39 |
|
Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.
Pssm-ID: 462418 Cd Length: 97 Bit Score: 141.60 E-value: 1.61e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 457 ECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSVTSG-SEDY-SFKHMRRNQYEESLFRCEDDRFELDMLLESVSSA 534
Cdd:pfam08295 1 KRCGPSYRLLPKSEPQLPCSGRDELCWEVLNDEWVSHPTWaSEDSgSFVAHRKNQYEEALFRCEDERYEYDMHIESNLRT 80
|
90
....*....|....*.
gi 334185014 535 ARSAESLLNIITEKKI 550
Cdd:pfam08295 81 IKLLEPIAEKINNMSP 96
|
|
| Sin3 |
COG5602 |
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]; |
1080-1329 |
5.09e-13 |
|
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
Pssm-ID: 227889 [Multi-domain] Cd Length: 1163 Bit Score: 74.18 E-value: 5.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1080 ERTKDLQVFYGNDDFYVLFRLHQILYERILYAKRncsggeLKSKNLKDTNAGDPYARFMRVLYGLLDGSAENTKFEDECR 1159
Cdd:COG5602 852 EKQVIALTEFGNSLMYVFFRLRFDSYERLYEIKK------IKEAVTIGMMEPGHYENELWDSYRLIFGALTPCEFEKYLR 925
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1160 AIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYYEN-VR-VLVHEENIYRLECSSLP 1237
Cdd:COG5602 926 PFYNNTCYKIYTIDRLRQSLKKQLHPITYDIKYIAKSELFEMNSAASSKRKQDQTKYRLeVEsLLNPDEILFRFCWINKF 1005
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1238 SRLSIQLM---DNIIEKPEA-----------YAVSMDPTFASYMQTEL----LSVSSGKKEEGHDIVLQRNLTGLYdlck 1299
Cdd:COG5602 1006 KSFGIQIMkraDLTVDQSLDtqrvwkyyvqsYAIQHLTEGISYKNYKCpflcRNIEKERTVEQLVSRLQTKLLRSH---- 1081
|
250 260 270
....*....|....*....|....*....|
gi 334185014 1300 amegvEVVNGLECKMSCSSYKIAYVLDTED 1329
Cdd:COG5602 1082 -----ELVSGLQAFLCLDTFKLLYLPNTED 1106
|
|
| HN_RTEL1 |
cd13932 |
harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL); ... |
46-144 |
4.54e-04 |
|
harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL); Mouse Rtel is an essential protein required for the maintenance of both telomeric and genomic stability. RTEL1 appears to maintain genome stability by suppressing homologous recombination (HR). In vitro, purified human and insect RTEL1 have been shown to promote the disassembly of D loop recombination intermediates, in a reaction dependent upon ATP hydrolysis. Human RTEL1 is implicated in the etiology of Dyskeratosis congenital (DC, is an inherited bone marrow failure and cancer predisposition syndrome). Point mutations in its helicase domains, and truncations which result in loss of its C-terminus have been discovered in DC families. RTEL1 is also a candidate gene influencing glioma susceptibility. The C-terminal domain of RTEL1, represented here, appears similar to the N-terminal domain of the scaffolding protein harmonin.
Pssm-ID: 259826 [Multi-domain] Cd Length: 99 Bit Score: 40.72 E-value: 4.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 46 SRRVSQKLTTNDALSYLREVKEMFqdQREKYDRFLEVMKDFKaQRTDTGGVIARVKELFKGHN--NLIYGFNTFLPkgye 123
Cdd:cd13932 8 SSSSGAKPAPESASAFLREVKQKL--SAAEYRQFSAALQAYK-TGDDFEQLLAVLAELFAEPErhPLLRGFRRFVR---- 80
|
90 100
....*....|....*....|.
gi 334185014 124 itlieeddalPKKTVEFEQAI 144
Cdd:cd13932 81 ----------PHHKKEFDERC 91
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
919-1060 |
2.16e-03 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 42.68 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 919 LANGLRSDS-SKGTRNSDDPEGPSRNEKEEGELS-----PNGDFEDNFGVYKDHGVKSTSKPEN-SAEAEVEADAEVENE 991
Cdd:TIGR00927 630 LSKGDVAEAeHTGERTGEEGERPTEAEGENGEESggeaeQEGETETKGENESEGEIPAERKGEQeGEGEIEAKEADHKGE 709
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334185014 992 DDADDVDSENASEASGTESGGDVCSQDEDREEENGEHDEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1060
Cdd:TIGR00927 710 TEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDE 778
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
874-1060 |
4.78e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 41.11 E-value: 4.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 874 GKEVLPGAHEIQAKPSDTLTDIHHDVDSIETVHSTQGGDVGNSIVLANG---LRSDSSKGTRNSDDPEGPSRNEKEEGEL 950
Cdd:PHA03169 34 GRRRGTAARAAKPAPPAPTTSGPQVRAVAEQGHRQTESDTETAEESRHGekeERGQGGPSGSGSESVGSPTPSPSGSAEE 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 951 SPNGDFEDNFGVYKDHGVKSTSKPEnsaeaeveadaevenEDDADDVDSENASEASGTESGGDVCSQ--DEDREEENGEH 1028
Cdd:PHA03169 114 LASGLSPENTSGSSPESPASHSPPP---------------SPPSHPGPHEPAPPESHNPSPNQQPSSflQPSHEDSPEEP 178
|
170 180 190
....*....|....*....|....*....|..
gi 334185014 1029 DEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1060
Cdd:PHA03169 179 EPPTSEPEPDSPGPPQSETPTSSPPPQSPPDE 210
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Sin3 |
COG5602 |
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]; |
13-660 |
4.82e-89 |
|
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
Pssm-ID: 227889 [Multi-domain] Cd Length: 1163 Bit Score: 314.93 E-value: 4.82e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 13 SQFRRPLGSSRGQLCGQSPVHGSGDTEEEEEGGSRRVS-QKLTTNDALSYLREVKEMFQDQREKYDRFLEVMKDFKAQRT 91
Cdd:COG5602 85 EDVEQILSSLAGDNPDPSTDHGSASNQNMERSPPPRIPyRPLDVSDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKSQAI 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 92 DTGGVIARVKELFKGHNNLIYGFNTFLPKGYEITLIEED----------------------------------------- 130
Cdd:COG5602 165 DTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLPQpngsrlhvttpqgplssppvqssyyvapcnhdqrtshptlp 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 131 ---------------DALPKKTVEFEQAINFVNKIKMRFKHDEHVYKSFLEILNMYRKENKEIKEVYNEVSILFQGHLDL 195
Cdd:COG5602 245 sdsqpepsapshmpsDARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSIQEVYARVTKLFAEAPDL 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 196 LEQFTRFLPASlpSHSAAQhSRSQAQQYSDRGSDPPLLHQMQVEKERRRERavalrgdysverydlnddktmvkiQREQR 275
Cdd:COG5602 325 LEEFKEFLPDS--SVSAEQ-STANAQKPSKRLPPIGSFSLPTAAPEQNRPS------------------------LLWES 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 276 KRLDKENRARRGRDLDDREagqdnLHHFPEKRKSSrraealeaYSGMYKQAFVFCEKVKDRLCSQDDYQTFLKCLNIFSN 355
Cdd:COG5602 378 PRSISNISRYRADLLTSFS-----RNFVPIRIHMP--------ISHLSNESEDFFERIKQYLKDKNLYHEFLKLLNLYSQ 444
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 356 GIIQRKDLQNLVSDLLGKFPDLMDEFNQFFERCESItdgfqrlagvmskklfssEEQLSRPMKveekesehkpeleavke 435
Cdd:COG5602 445 KIIDKNDLVERLFAFLGSNEELIRWFKAFINYSEPE------------------KEPLRETRK----------------- 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 436 teqckkeymgksiqelDLSDCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSV-TSGSEDYSFKHMRRNQYEESL 514
Cdd:COG5602 490 ----------------DLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHpTWASEDSGFIAHRKNQYEEAL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 515 FRCEDDRFELDMLLESVSSAARSAESLLNIITEKKISFSGSFRIEDHFTALNLRCIER----LYG-DHGLDVIDILNKNP 589
Cdd:COG5602 554 FKIEEERYEYDRHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKvikkVYDkEHAPEILEALLKKP 633
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185014 590 ATALPVILTRLKQKQGEWKKCRDDFDKVWANVYAKNHYKSLDHRSFYFKQQDSKNLSAKSLLAEIKELKEK 660
Cdd:COG5602 634 HVTIPIVLKRLKMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEIDDRSQA 704
|
|
| Sin3a_C |
pfam16879 |
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at ... |
1088-1331 |
4.85e-52 |
|
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at the C-terminus of the co-repressor Sin3a, and downstream of family Sin3_corepress, pfam08295.
Pssm-ID: 465294 Cd Length: 281 Bit Score: 184.73 E-value: 4.85e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1088 FYGNDDFYVLFRLHQILYERILYAKRNCS--GGELKSKN-------------------LKDTNAGDPYARFMRVLYGLLD 1146
Cdd:pfam16879 1 FFANTTIYVFFRLFQILYERLLKIKQAEEevAEEIKRRKankpakdlgliskeledfgLDLSDPEDYYPQLLELCERLID 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1147 GSAENTKFEDECRAIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYY-ENVRVLV-H 1224
Cdd:pfam16879 81 GEIDQSQFEDSLRQMYGNKAYKLYTIDKLIQALVKQLQTIVSDSKSQELLELFEKERSKEETTAQDEILYrKQAEKLLgK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1225 EENIYRLECSSLPSRLSIQLMDNIIEKPEAYAVSMDPTFASYMQ-------TELLSVSSGKKeeghdIVLQRNLTGL--- 1294
Cdd:pfam16879 161 DENLFRIEWNPQSKTVTIQLLDKDDLTFDDDELTAEERWQYYVSsyvlshpTEGVPRSKLRK-----PFLKRNLKAEree 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 334185014 1295 ---------YDLCKAMEGVEVVNGLECKMSCSSYKIAYVLDTEDYF 1331
Cdd:pfam16879 236 eedeeeepkADAEEPEGPLEFESGLEIRICLNSYKLFYVPGTEDYF 281
|
|
| HDAC_interact |
smart00761 |
Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It ... |
455-551 |
5.38e-45 |
|
Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.
Pssm-ID: 214808 [Multi-domain] Cd Length: 102 Bit Score: 157.47 E-value: 5.38e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 455 DCECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSVTSG-SEDYSFKHMRRNQYEESLFRCEDDRFELDMLLESVSS 533
Cdd:smart00761 1 NCERCGPSYRLLPKSEKQPKCSGRDELCKEVLNDTWVSHPTWaSEDSGFVAHRKNQYEEALFRCEDERFELDMVIESNSS 80
|
90
....*....|....*...
gi 334185014 534 AARSAESLLNIITEKKIS 551
Cdd:smart00761 81 TIKLLEEILNKIEDMSDE 98
|
|
| Sin3_corepress |
pfam08295 |
Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms ... |
457-550 |
1.61e-39 |
|
Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.
Pssm-ID: 462418 Cd Length: 97 Bit Score: 141.60 E-value: 1.61e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 457 ECCTPSYRLLPADYPIPIASQRSELGAEVLNDHWVSVTSG-SEDY-SFKHMRRNQYEESLFRCEDDRFELDMLLESVSSA 534
Cdd:pfam08295 1 KRCGPSYRLLPKSEPQLPCSGRDELCWEVLNDEWVSHPTWaSEDSgSFVAHRKNQYEEALFRCEDERYEYDMHIESNLRT 80
|
90
....*....|....*.
gi 334185014 535 ARSAESLLNIITEKKI 550
Cdd:pfam08295 81 IKLLEPIAEKINNMSP 96
|
|
| PAH |
pfam02671 |
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ... |
159-203 |
1.86e-15 |
|
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.
Pssm-ID: 460645 [Multi-domain] Cd Length: 45 Bit Score: 71.30 E-value: 1.86e-15
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 334185014 159 HVYKSFLEILNMYRKENKEIKEVYNEVSILFQGHLDLLEQFTRFL 203
Cdd:pfam02671 1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
|
|
| PAH |
pfam02671 |
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ... |
74-118 |
3.21e-15 |
|
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.
Pssm-ID: 460645 [Multi-domain] Cd Length: 45 Bit Score: 70.53 E-value: 3.21e-15
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 334185014 74 EKYDRFLEVMKDFKAQRTDTGGVIARVKELFKGHNNLIYGFNTFL 118
Cdd:pfam02671 1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
|
|
| PAH |
pfam02671 |
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ... |
341-385 |
2.26e-13 |
|
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.
Pssm-ID: 460645 [Multi-domain] Cd Length: 45 Bit Score: 65.52 E-value: 2.26e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 334185014 341 DDYQTFLKCLNIFSNGIIQRKDLQNLVSDLLGKFPDLMDEFNQFF 385
Cdd:pfam02671 1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
|
|
| Sin3 |
COG5602 |
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]; |
1080-1329 |
5.09e-13 |
|
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
Pssm-ID: 227889 [Multi-domain] Cd Length: 1163 Bit Score: 74.18 E-value: 5.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1080 ERTKDLQVFYGNDDFYVLFRLHQILYERILYAKRncsggeLKSKNLKDTNAGDPYARFMRVLYGLLDGSAENTKFEDECR 1159
Cdd:COG5602 852 EKQVIALTEFGNSLMYVFFRLRFDSYERLYEIKK------IKEAVTIGMMEPGHYENELWDSYRLIFGALTPCEFEKYLR 925
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1160 AIIGNQSYVLFTLDKLIYRLVKQLQAIVADEMDNKLLQLYEYEKSRKPGRVIDSVYYEN-VR-VLVHEENIYRLECSSLP 1237
Cdd:COG5602 926 PFYNNTCYKIYTIDRLRQSLKKQLHPITYDIKYIAKSELFEMNSAASSKRKQDQTKYRLeVEsLLNPDEILFRFCWINKF 1005
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 1238 SRLSIQLM---DNIIEKPEA-----------YAVSMDPTFASYMQTEL----LSVSSGKKEEGHDIVLQRNLTGLYdlck 1299
Cdd:COG5602 1006 KSFGIQIMkraDLTVDQSLDtqrvwkyyvqsYAIQHLTEGISYKNYKCpflcRNIEKERTVEQLVSRLQTKLLRSH---- 1081
|
250 260 270
....*....|....*....|....*....|
gi 334185014 1300 amegvEVVNGLECKMSCSSYKIAYVLDTED 1329
Cdd:COG5602 1082 -----ELVSGLQAFLCLDTFKLLYLPNTED 1106
|
|
| HN_RTEL1 |
cd13932 |
harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL); ... |
46-144 |
4.54e-04 |
|
harmonin_N_like domain of regulator of telomere elongation helicase 1 (also known as RTEL); Mouse Rtel is an essential protein required for the maintenance of both telomeric and genomic stability. RTEL1 appears to maintain genome stability by suppressing homologous recombination (HR). In vitro, purified human and insect RTEL1 have been shown to promote the disassembly of D loop recombination intermediates, in a reaction dependent upon ATP hydrolysis. Human RTEL1 is implicated in the etiology of Dyskeratosis congenital (DC, is an inherited bone marrow failure and cancer predisposition syndrome). Point mutations in its helicase domains, and truncations which result in loss of its C-terminus have been discovered in DC families. RTEL1 is also a candidate gene influencing glioma susceptibility. The C-terminal domain of RTEL1, represented here, appears similar to the N-terminal domain of the scaffolding protein harmonin.
Pssm-ID: 259826 [Multi-domain] Cd Length: 99 Bit Score: 40.72 E-value: 4.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 46 SRRVSQKLTTNDALSYLREVKEMFqdQREKYDRFLEVMKDFKaQRTDTGGVIARVKELFKGHN--NLIYGFNTFLPkgye 123
Cdd:cd13932 8 SSSSGAKPAPESASAFLREVKQKL--SAAEYRQFSAALQAYK-TGDDFEQLLAVLAELFAEPErhPLLRGFRRFVR---- 80
|
90 100
....*....|....*....|.
gi 334185014 124 itlieeddalPKKTVEFEQAI 144
Cdd:cd13932 81 ----------PHHKKEFDERC 91
|
|
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
919-1060 |
2.16e-03 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 42.68 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 919 LANGLRSDS-SKGTRNSDDPEGPSRNEKEEGELS-----PNGDFEDNFGVYKDHGVKSTSKPEN-SAEAEVEADAEVENE 991
Cdd:TIGR00927 630 LSKGDVAEAeHTGERTGEEGERPTEAEGENGEESggeaeQEGETETKGENESEGEIPAERKGEQeGEGEIEAKEADHKGE 709
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334185014 992 DDADDVDSENASEASGTESGGDVCSQDEDREEENGEHDEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1060
Cdd:TIGR00927 710 TEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGETEAEGKEDE 778
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
874-1060 |
4.78e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 41.11 E-value: 4.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 874 GKEVLPGAHEIQAKPSDTLTDIHHDVDSIETVHSTQGGDVGNSIVLANG---LRSDSSKGTRNSDDPEGPSRNEKEEGEL 950
Cdd:PHA03169 34 GRRRGTAARAAKPAPPAPTTSGPQVRAVAEQGHRQTESDTETAEESRHGekeERGQGGPSGSGSESVGSPTPSPSGSAEE 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 951 SPNGDFEDNFGVYKDHGVKSTSKPEnsaeaeveadaevenEDDADDVDSENASEASGTESGGDVCSQ--DEDREEENGEH 1028
Cdd:PHA03169 114 LASGLSPENTSGSSPESPASHSPPP---------------SPPSHPGPHEPAPPESHNPSPNQQPSSflQPSHEDSPEEP 178
|
170 180 190
....*....|....*....|....*....|..
gi 334185014 1029 DEIDGKAESEGEAEGMDPHLLEGESELLPQSE 1060
Cdd:PHA03169 179 EPPTSEPEPDSPGPPQSETPTSSPPPQSPPDE 210
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
903-1043 |
5.31e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 40.72 E-value: 5.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185014 903 ETVHSTQGGDVGNSIVLANGLR-SDSSKGTRNSDDPEGPSRNEKEEGELSPNGDFEDNFGVYKDHGvKSTSKPENSAEAE 981
Cdd:PHA03169 98 ESVGSPTPSPSGSAEELASGLSpENTSGSSPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQP-SSFLQPSHEDSPE 176
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334185014 982 VEADAEVENEDDADDV-DSENASEASGTESGGDvcSQDEDREEENGEHDEIDGK--AESEGEAEG 1043
Cdd:PHA03169 177 EPEPPTSEPEPDSPGPpQSETPTSSPPPQSPPD--EPGEPQSPTPQQAPSPNTQqaVEHEDEPTE 239
|
|
| |
