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Conserved domains on  [gi|357197123|ref|NP_001239394|]
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target of rapamycin complex subunit LST8 isoform 2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-254 3.06e-45

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.61  E-value: 3.06e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123   5 NSNNPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQS 83
Cdd:COG2319  148 DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSAD 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  84 GAIHIWDLKTDHNEQLIPEPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGigddvtQLIpkTKIPAHTRYALQCRFS 163
Cdd:COG2319  226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFS 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123 164 PDSTLLATCSADQTCKIWRTSNFSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYG 243
Cdd:COG2319  298 PDGKLLASGSDDGTVRLWDLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369

                        250
                 ....*....|.
gi 357197123 244 GHQKAVVCLAF 254
Cdd:COG2319  370 GHTGAVTSVAF 380
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-254 3.06e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.61  E-value: 3.06e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123   5 NSNNPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQS 83
Cdd:COG2319  148 DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSAD 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  84 GAIHIWDLKTDHNEQLIPEPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGigddvtQLIpkTKIPAHTRYALQCRFS 163
Cdd:COG2319  226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFS 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123 164 PDSTLLATCSADQTCKIWRTSNFSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYG 243
Cdd:COG2319  298 PDGKLLASGSDDGTVRLWDLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369

                        250
                 ....*....|.
gi 357197123 244 GHQKAVVCLAF 254
Cdd:COG2319  370 GHTGAVTSVAF 380
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-231 9.38e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.61  E-value: 9.38e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123   5 NSNNPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQ-VNAPINCVCLHPNQAELIVGDQS 83
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRgHTDWVNSVAFSPDGTFVASSSQD 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  84 GAIHIWDLKTDHNEQLIPEPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGigdDVTQLipktkIPAHTRYALQCRFS 163
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG---KCLGT-----LRGHENGVNSVAFS 228

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 357197123 164 PDSTLLATCSADQTCKIWRTSNFSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLW 231
Cdd:cd00200  229 PDGYLLASGSEDGTIRVWDLRTGECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 146-181 8.27e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 8.27e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 357197123   146 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 181
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
146-181 4.00e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 4.00e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 357197123  146 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 181
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-254 3.06e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.61  E-value: 3.06e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123   5 NSNNPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQS 83
Cdd:COG2319  148 DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGhTGAVRSVAFSPDGKLLASGSAD 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  84 GAIHIWDLKTDHNEQLIPEPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGigddvtQLIpkTKIPAHTRYALQCRFS 163
Cdd:COG2319  226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG------ELL--RTLTGHSGGVNSVAFS 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123 164 PDSTLLATCSADQTCKIWRTSNFSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYG 243
Cdd:COG2319  298 PDGKLLASGSDDGTVRLWDLATGKLLRTLT--------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369

                        250
                 ....*....|.
gi 357197123 244 GHQKAVVCLAF 254
Cdd:COG2319  370 GHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
5-254 9.23e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.76  E-value: 9.23e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123   5 NSNNPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQcQRIFQVNAPINCVCLHPNQAELIVGDQSG 84
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDG 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  85 AIHIWDLKTDHNEQLIPEPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGigddvtQLIpkTKIPAHTRYALQCRFSP 164
Cdd:COG2319  185 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG------KLL--RTLTGHSGSVRSVAFSP 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123 165 DSTLLATCSADQTCKIWRTSNFSLMTELsikssnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGG 244
Cdd:COG2319  257 DGRLLASGSADGTVRLWDLATGELLRTL--------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                        250
                 ....*....|
gi 357197123 245 HQKAVVCLAF 254
Cdd:COG2319  329 HTGAVRSVAF 338
WD40 COG2319
WD40 repeat [General function prediction only];
11-254 3.31e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.13  E-value: 3.31e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  11 PIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQcQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWD 90
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLL-RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  91 LKTDHNEQLIPEPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGigddvtQLIpkTKIPAHTRYALQCRFSPDSTLLA 170
Cdd:COG2319  149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG------KLL--RTLTGHTGAVRSVAFSPDGKLLA 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123 171 TCSADQTCKIWRTSNFSLMTELsikssnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVV 250
Cdd:COG2319  221 SGSADGTVRLWDLATGKLLRTL--------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVN 292


                 ....
gi 357197123 251 CLAF 254
Cdd:COG2319  293 SVAF 296
WD40 COG2319
WD40 repeat [General function prediction only];
5-231 1.06e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 1.06e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123   5 NSNNPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQS 83
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG--KLLRTLTGhSGSVRSVAFSPDGRLLASGSAD 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  84 GAIHIWDLKTDHNEQLIPEPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGigddvtQLIpkTKIPAHTRYALQCRFS 163
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG------KLL--RTLTGHTGAVRSVAFS 339

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 357197123 164 PDSTLLATCSADQTCKIWRTSNFSLMTELsikssnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLW 231
Cdd:COG2319  340 PDGKTLASGSDDGTVRLWDLATGELLRTL--------TGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-231 9.38e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.61  E-value: 9.38e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123   5 NSNNPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQ-VNAPINCVCLHPNQAELIVGDQS 83
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRgHTDWVNSVAFSPDGTFVASSSQD 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  84 GAIHIWDLKTDHNEQLIPEPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGigdDVTQLipktkIPAHTRYALQCRFS 163
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG---KCLGT-----LRGHENGVNSVAFS 228

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 357197123 164 PDSTLLATCSADQTCKIWRTSNFSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLW 231
Cdd:cd00200  229 PDGYLLASGSEDGTIRVWDLRTGECVQTLS--------GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-257 1.79e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.84  E-value: 1.79e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  19 SKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQVNA-PINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNE 97
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTgPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  98 QLIPEPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGigddvtqlIPKTKIPAHTRYALQCRFSPDSTLLATCSADQT 177
Cdd:cd00200   87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--------KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123 178 CKIWRTSNFSLMTELsikssnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 257
Cdd:cd00200  159 IKLWDLRTGKCVATL--------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD 230
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-257 1.77e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 1.77e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  19 SKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLqCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQ 98
Cdd:cd00200   51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC-VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  99 LIPEPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGIgddvtqliPKTKIPAHTRYALQCRFSPDSTLLATCSADQTC 178
Cdd:cd00200  130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--------CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTI 201

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 357197123 179 KIWRTSNFSLMTELsikssnpgESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDS 257
Cdd:cd00200  202 KLWDLSTGKCLGTL--------RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPD 272
WD40 COG2319
WD40 repeat [General function prediction only];
26-255 3.90e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 3.90e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  26 GFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVcLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPES 105
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLA-ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123 106 SITSAHIDPDASYMAAVNSAGNCYVWNLTGGIgddvtqliPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSN 185
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGL--------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123 186 FSLMTELSikssnpgeSSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFN 255
Cdd:COG2319  152 GKLLRTLT--------GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS 213
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-182 8.19e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.41  E-value: 8.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123   5 NSNNPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWDLRSrnLQCQRIFQV-NAPINCVCLHPNQAELIVGDQS 83
Cdd:cd00200  121 DVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT--GKCVATLTGhTGEVNSVAFSPDGEKLLSSSSD 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  84 GAIHIWDLKTDHNEQLIPEPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGigddvtqlIPKTKIPAHTRYALQCRFS 163
Cdd:cd00200  199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG--------ECVQTLSGHTNSVTSLAWS 270

                        170
                 ....*....|....*....
gi 357197123 164 PDSTLLATCSADQTCKIWR 182
Cdd:cd00200  271 PDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
5-185 1.12e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.12e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123   5 NSNNPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRnlQCQRIFQV-NAPINCVCLHPNQAELIVGDQS 83
Cdd:COG2319  232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG--ELLRTLTGhSGGVNSVAFSPDGKLLASGSDD 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123  84 GAIHIWDLKTDHNEQLIPEPESSITSAHIDPDASYMAAVNSAGNCYVWNLTGGIgddvtqliPKTKIPAHTRYALQCRFS 163
Cdd:COG2319  310 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--------LLRTLTGHTGAVTSVAFS 381

                        170       180
                 ....*....|....*....|..
gi 357197123 164 PDSTLLATCSADQTCKIWRTSN 185
Cdd:COG2319  382 PDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-257 1.87e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 1.87e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197123 150 IPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSsnpgessrGWMWGCAFSGDSQYIVTASSDNLAR 229
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHT--------GPVRDVAASADGTYLASGSSDKTIR 76

                         90       100
                 ....*....|....*....|....*...
gi 357197123 230 LWCVETGEIKREYGGHQKAVVCLAFNDS 257
Cdd:cd00200   77 LWDLETGECVRTLTGHTSYVSSVAFSPD 104
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 146-181 8.27e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 8.27e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 357197123   146 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 181
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
146-181 4.00e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 4.00e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 357197123  146 PKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIW 181
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
10-47 5.55e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 5.55e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 357197123   10 NPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWD 47
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 8-47 1.13e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.13e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 357197123     8 NPNPIISYDGVSKNIASVGFHEDGRWMYTGGEDCTARIWD 47
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 204-231 5.35e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 5.35e-03
                           10        20
                   ....*....|....*....|....*...
gi 357197123   204 RGWMWGCAFSGDSQYIVTASSDNLARLW 231
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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