uncharacterized protein Dmel_CG14200, isoform C [Drosophila melanogaster]
Protein Classification
PWWP domain-containing protein( domain architecture ID 10142404)
PWWP domain-containing protein similar to Arabidopsis thaliana PWWP domain-containing proteins that mediate H3K27 trimethylation on FLC and regulate flowering time
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| PWWP | cd05162 | PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, ... |
17-99 | 2.94e-12 | ||||
PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids and is composed of a five-stranded antiparallel beta-barrel followed by a helical region. It is found in numerous proteins that are involved in cell division, growth, and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes. PWWP domains specifically recognize DNA and histone methylated lysines at the level of the nucleosome. Based on the fact that other regions of PWWP-domain proteins are responsible for nuclear localization and DNA-binding, is likely that the PWWP domain acts as a site for protein-protein binding interactions, influencing chromatin remodeling and thereby regulating transcriptional processes. Some PWWP-domain proteins have been linked to cancer or other diseases; some are known to function as growth factors. : Pssm-ID: 438958 [Multi-domain] Cd Length: 86 Bit Score: 64.06 E-value: 2.94e-12
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| PHA03247 super family | cl33720 | large tegument protein UL36; Provisional |
343-521 | 1.85e-03 | ||||
large tegument protein UL36; Provisional The actual alignment was detected with superfamily member PHA03247: Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.77 E-value: 1.85e-03
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| Name | Accession | Description | Interval | E-value | ||||
| PWWP | cd05162 | PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, ... |
17-99 | 2.94e-12 | ||||
PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids and is composed of a five-stranded antiparallel beta-barrel followed by a helical region. It is found in numerous proteins that are involved in cell division, growth, and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes. PWWP domains specifically recognize DNA and histone methylated lysines at the level of the nucleosome. Based on the fact that other regions of PWWP-domain proteins are responsible for nuclear localization and DNA-binding, is likely that the PWWP domain acts as a site for protein-protein binding interactions, influencing chromatin remodeling and thereby regulating transcriptional processes. Some PWWP-domain proteins have been linked to cancer or other diseases; some are known to function as growth factors. Pssm-ID: 438958 [Multi-domain] Cd Length: 86 Bit Score: 64.06 E-value: 2.94e-12
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| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
343-521 | 1.85e-03 | ||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.77 E-value: 1.85e-03
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| Name | Accession | Description | Interval | E-value | ||||
| PWWP | cd05162 | PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, ... |
17-99 | 2.94e-12 | ||||
PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids and is composed of a five-stranded antiparallel beta-barrel followed by a helical region. It is found in numerous proteins that are involved in cell division, growth, and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes. PWWP domains specifically recognize DNA and histone methylated lysines at the level of the nucleosome. Based on the fact that other regions of PWWP-domain proteins are responsible for nuclear localization and DNA-binding, is likely that the PWWP domain acts as a site for protein-protein binding interactions, influencing chromatin remodeling and thereby regulating transcriptional processes. Some PWWP-domain proteins have been linked to cancer or other diseases; some are known to function as growth factors. Pssm-ID: 438958 [Multi-domain] Cd Length: 86 Bit Score: 64.06 E-value: 2.94e-12
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| PWWP_PWWP2 | cd20140 | PWWP domain found in the PWWP domain-containing protein 2 (PWWP2) family; The PWWP2 family ... |
17-92 | 5.10e-06 | ||||
PWWP domain found in the PWWP domain-containing protein 2 (PWWP2) family; The PWWP2 family includes PWWP2A and its paralog PWWP2B. PWWP2A is a H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. It is also required for proper mitosis progression. PWWP2A and PWWP2B form a stable complex with NuRD subunits MTA1/2/3:HDAC1/2:RBBP4/7, but not with MBD2/3, p66alpha/beta, and CHD3/4. The PWWP domain specifically recognizes DNA and histone methylated lysines. Pssm-ID: 438968 Cd Length: 92 Bit Score: 46.49 E-value: 5.10e-06
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| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
343-521 | 1.85e-03 | ||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.77 E-value: 1.85e-03
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| Blast search parameters | ||||
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