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Conserved domains on  [gi|4502719|ref|NP_001248|]
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cadherin-13 isoform 1 preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_pro super family cl07391
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 3.09e-31

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


The actual alignment was detected with superfamily member pfam08758:

Pssm-ID: 471661  Cd Length: 90  Bit Score: 117.04  E-value: 3.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719     27 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGK--TLFVHARTPHAE 104
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHGE 81


                  ....*..
gi 4502719    105 DMAELVI 111
Cdd:pfam08758  82 KMASVKV 88
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 488-581 4.54e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 4.54e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719  488 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 566
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
gi 4502719  567 GTGTLLITLEDVNDN 581
Cdd:cd11304  84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-359 4.97e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 4.97e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719  249 PYIGHVMEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYE 328
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYT 69

                        90       100       110
                ....*....|....*....|....*....|.
gi 4502719  329 LIIEAQDMAGLdvGLTGTATATIMIDDKNDH 359
Cdd:cd11304  70 LTVTATDGGGP--PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-243 1.18e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 1.18e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719     161 KVVDSDRPERSKFRLTGkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQND 240
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 4502719     241 NRP 243
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
368-469 3.77e-17

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 3.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719    368 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 445
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 4502719    446 NEDPlvpdvsYGPSSTATVHITVL 469
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 589-680 2.88e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 2.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719    589 VAEVCDDAK-NLSVVILGASDKDLHPNTDPFKFEIhkQAVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 664
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 4502719    665 GKPPMTNITDLRVQVC 680
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 3.09e-31

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 117.04  E-value: 3.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719     27 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGK--TLFVHARTPHAE 104
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHGE 81


                  ....*..
gi 4502719    105 DMAELVI 111
Cdd:pfam08758  82 KMASVKV 88
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 488-581 4.54e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 4.54e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719  488 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 566
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
gi 4502719  567 GTGTLLITLEDVNDN 581
Cdd:cd11304  84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-359 4.97e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 4.97e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719  249 PYIGHVMEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYE 328
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYT 69

                        90       100       110
                ....*....|....*....|....*....|.
gi 4502719  329 LIIEAQDMAGLdvGLTGTATATIMIDDKNDH 359
Cdd:cd11304  70 LTVTATDGGGP--PLSSTATVTITVLDVNDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 5.59e-21

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 87.72  E-value: 5.59e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719      27 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVG--KTLFVHARTPHAE 104
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSekKSFTVLAWDSQGQ 80


                   ....*..
gi 4502719     105 DMAELVI 111
Cdd:smart01055  81 EKKEIKV 87
Cadherin pfam00028
Cadherin domain;
250-351 1.60e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719    250 YIGHVMEGSPTGTTVMRMTAFDADDPatDNALLRYNIRQQtpdkPSPNMFYIDPEKGDIvTVVSPalLDREtlENPKYEL 329
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDI-STTKP--LDRE--SIGEYEL 69

                          90       100
                  ....*....|....*....|..
gi 4502719    330 IIEAQDMAGldVGLTGTATATI 351
Cdd:pfam00028  70 TVEATDSGG--PPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 500-583 7.20e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 7.20e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719     500 NATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDREspfvDNSVYTALFLAIDSGNPPATGTGTLLITLEDV 578
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 4502719     579 NDNAP 583
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-243 1.18e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 1.18e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719     161 KVVDSDRPERSKFRLTGkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQND 240
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 4502719     241 NRP 243
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
368-469 3.77e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 3.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719    368 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 445
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 4502719    446 NEDPlvpdvsYGPSSTATVHITVL 469
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
488-576 4.28e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 4.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719    488 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 566
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 4502719    567 GTGTLLITLE 576
Cdd:pfam00028  83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 367-473 1.16e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719  367 EFQATVEEGA-VG-VIVNLTVEDKDDPTTGawRAAYTIINGNPGQSFEIHTNpqtnEGMLSVVKPLDYEISAFHTLLIKV 444
Cdd:cd11304   1 SYEVSVPENApPGtVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....*....
gi 4502719  445 enEDPLVPdvsyGPSSTATVHITVLDVNE 473
Cdd:cd11304  75 --TDGGGP----PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 147-241 1.28e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.28e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719  147 IPENQRQPFPrdVGKV--VDSDRPERSK--FRLtgkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNG 222
Cdd:cd11304   6 VPENAPPGTV--VLTVsaTDPDSGENGEvtYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 4502719  223 KTLEGPVPLEVIVIDQNDN 241
Cdd:cd11304  80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 268-361 7.00e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 7.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719     268 TAFDADDPatDNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDREtlENPKYELIIEAQDMAGldVGLTGTA 347
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDD----GLFSIDPETGEITTTKP---LDRE--EQPEYTLTVEATDGGG--PPLSSTA 67

                           90
                   ....*....|....
gi 4502719     348 TATIMIDDKNDHSP 361
Cdd:smart00112  68 TVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
144-236 1.27e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 1.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719    144 PILIPENQR-QPFPRDVGkVVDSDRPERSK--FRLTGkgvdQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDV 220
Cdd:pfam00028   2 SASVPENAPvGTEVLTVT-ATDPDLGPNGRifYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 4502719    221 NGKTLEGPVPLEVIVI 236
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-475 3.52e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 3.52e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719     384 TVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVENEDplvpdvSYGPSSTAT 463
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTAT 68

                           90
                   ....*....|..
gi 4502719     464 VHITVLDVNEGP 475
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
589-680 2.88e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 2.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719    589 VAEVCDDAK-NLSVVILGASDKDLHPNTDPFKFEIhkQAVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 664
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 4502719    665 GKPPMTNITDLRVQVC 680
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 587-680 3.54e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 3.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719  587 PTVAEVCDDAKNLSVVI-LGASDKDLHPNtDPFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVT 662
Cdd:cd11304   1 SYEVSVPENAPPGTVVLtVSATDPDSGEN-GEVTYSIVSGNEDGLF----SIDPSTGEITTAKPLDreeQSSYTLTVTAT 75

                        90
                ....*....|....*...
gi 4502719  663 DSGKPPMTNITDLRVQVC 680
Cdd:cd11304  76 DGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 606-680 1.27e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.10  E-value: 1.27e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502719     606 ASDKDLHPNTDpFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDSGKPPMTNITDLRVQVC 680
Cdd:smart00112   2 ATDADSGENGK-VTYSILSGNDDGLF----SIDPETGEITTTKPLDreeQPEYTLTVEATDGGGPPLSSTATVTITVL 74
 
Name Accession Description Interval E-value
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 3.09e-31

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 117.04  E-value: 3.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719     27 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGK--TLFVHARTPHAE 104
Cdd:pfam08758   2 CKPGFSEEVYTFSVPRRLEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRqtSFLVHAWDSHGE 81


                  ....*..
gi 4502719    105 DMAELVI 111
Cdd:pfam08758  82 KMASVKV 88
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 488-581 4.54e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 4.54e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719  488 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 566
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
gi 4502719  567 GTGTLLITLEDVNDN 581
Cdd:cd11304  84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-359 4.97e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 4.97e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719  249 PYIGHVMEGSPTGTTVMRMTAFDADDPAtdNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDRETLenPKYE 328
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNED----GLFSIDPSTGEITTAKP---LDREEQ--SSYT 69

                        90       100       110
                ....*....|....*....|....*....|.
gi 4502719  329 LIIEAQDMAGLdvGLTGTATATIMIDDKNDH 359
Cdd:cd11304  70 LTVTATDGGGP--PLSSTATVTITVLDVNDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 27-111 5.59e-21

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 87.72  E-value: 5.59e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719      27 CTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVG--KTLFVHARTPHAE 104
Cdd:smart01055   1 CKPGFSEEKYTFHVPSHLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSekKSFTVLAWDSQGQ 80


                   ....*..
gi 4502719     105 DMAELVI 111
Cdd:smart01055  81 EKKEIKV 87
Cadherin pfam00028
Cadherin domain;
250-351 1.60e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719    250 YIGHVMEGSPTGTTVMRMTAFDADDPatDNALLRYNIRQQtpdkPSPNMFYIDPEKGDIvTVVSPalLDREtlENPKYEL 329
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDI-STTKP--LDRE--SIGEYEL 69

                          90       100
                  ....*....|....*....|..
gi 4502719    330 IIEAQDMAGldVGLTGTATATI 351
Cdd:pfam00028  70 TVEATDSGG--PPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 500-583 7.20e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 7.20e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719     500 NATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDREspfvDNSVYTALFLAIDSGNPPATGTGTLLITLEDV 578
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 4502719     579 NDNAP 583
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-243 1.18e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.16  E-value: 1.18e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719     161 KVVDSDRPERSKFRLTGkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQND 240
Cdd:smart00112   1 SATDADSGENGKVTYSI--LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 4502719     241 NRP 243
Cdd:smart00112  79 NAP 81
Cadherin pfam00028
Cadherin domain;
368-469 3.77e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 3.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719    368 FQATVEEGAV--GVIVNLTVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVE 445
Cdd:pfam00028   1 YSASVPENAPvgTEVLTVTATDPDLGP--NGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
gi 4502719    446 NEDPlvpdvsYGPSSTATVHITVL 469
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
488-576 4.28e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 4.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719    488 EDLSVGSVLLTVNATDPDSLQHQTIRYS-VYKDPAGWLNINPINGTVDTTAVLDRESpfvdNSVYTALFLAIDSGNPPAT 566
Cdd:pfam00028   7 ENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGPPLS 82

                          90
                  ....*....|
gi 4502719    567 GTGTLLITLE 576
Cdd:pfam00028  83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 367-473 1.16e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719  367 EFQATVEEGA-VG-VIVNLTVEDKDDPTTGawRAAYTIINGNPGQSFEIHTNpqtnEGMLSVVKPLDYEISAFHTLLIKV 444
Cdd:cd11304   1 SYEVSVPENApPGtVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS----TGEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....*....
gi 4502719  445 enEDPLVPdvsyGPSSTATVHITVLDVNE 473
Cdd:cd11304  75 --TDGGGP----PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 147-241 1.28e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 1.28e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719  147 IPENQRQPFPrdVGKV--VDSDRPERSK--FRLtgkgVDQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNG 222
Cdd:cd11304   6 VPENAPPGTV--VLTVsaTDPDSGENGEvtYSI----VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 4502719  223 KTLEGPVPLEVIVIDQNDN 241
Cdd:cd11304  80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 268-361 7.00e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 7.00e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719     268 TAFDADDPatDNALLRYNIRQQTPDkpspNMFYIDPEKGDIVTVVSpalLDREtlENPKYELIIEAQDMAGldVGLTGTA 347
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDD----GLFSIDPETGEITTTKP---LDRE--EQPEYTLTVEATDGGG--PPLSSTA 67

                           90
                   ....*....|....
gi 4502719     348 TATIMIDDKNDHSP 361
Cdd:smart00112  68 TVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
144-236 1.27e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 1.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719    144 PILIPENQR-QPFPRDVGkVVDSDRPERSK--FRLTGkgvdQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDV 220
Cdd:pfam00028   2 SASVPENAPvGTEVLTVT-ATDPDLGPNGRifYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 4502719    221 NGKTLEGPVPLEVIVI 236
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 384-475 3.52e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.45  E-value: 3.52e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719     384 TVEDKDDPTtgAWRAAYTIINGNPGQSFEIHTNPqtneGMLSVVKPLDYEISAFHTLLIKVENEDplvpdvSYGPSSTAT 463
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEATDGG------GPPLSSTAT 68

                           90
                   ....*....|..
gi 4502719     464 VHITVLDVNEGP 475
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
589-680 2.88e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 2.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719    589 VAEVCDDAK-NLSVVILGASDKDLHPNTDPFKFEIhkQAVPDKVWKISKINNThalVSLLQNLN---KANYNLPIMVTDS 664
Cdd:pfam00028   2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSIL--GGGPGGNFRIDPDTGD---ISTTKPLDresIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 4502719    665 GKPPMTNITDLRVQVC 680
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 144-241 5.86e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 48.11  E-value: 5.86e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719  144 PILIPENQRQPfpRDVGKVvDSDRPERSK--FRLTGKGVDQEPkGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVN 221
Cdd:cd00031   3 DGSAVEGRSRG--SFRVSI-PTDLIASSGeiIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLG 78

                        90       100
                ....*....|....*....|
gi 4502719  222 GKTLEGPVPLEVIVIDQNDN 241
Cdd:cd00031  79 ANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 587-680 3.54e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 45.77  E-value: 3.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502719  587 PTVAEVCDDAKNLSVVI-LGASDKDLHPNtDPFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVT 662
Cdd:cd11304   1 SYEVSVPENAPPGTVVLtVSATDPDSGEN-GEVTYSIVSGNEDGLF----SIDPSTGEITTAKPLDreeQSSYTLTVTAT 75

                        90
                ....*....|....*...
gi 4502719  663 DSGKPPMTNITDLRVQVC 680
Cdd:cd11304  76 DGGGPPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 606-680 1.27e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.10  E-value: 1.27e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4502719     606 ASDKDLHPNTDpFKFEIHKQAVPDKVwkisKINNTHALVSLLQNLN---KANYNLPIMVTDSGKPPMTNITDLRVQVC 680
Cdd:smart00112   2 ATDADSGENGK-VTYSILSGNDDGLF----SIDPETGEITTTKPLDreeQPEYTLTVEATDGGGPPLSSTATVTITVL 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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