|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
93-548 |
8.25e-113 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 356.07 E-value: 8.25e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFdRLRRGSGKngggggAILADDMGLGKSLQTMAAtWALLKgsktAQQLANSCLIIVPSSLVNNWKAEF 172
Cdd:COG0553 242 LRPYQLEGAAWLL-FLRRLGLG------GLLADDMGLGKTIQALAL-LLELK----ERGLARPVLIVAPTSLVGNWQREL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 173 DKWWRLMRF-----PAVIALTANDITTYQstiklmpYLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLL 247
Cdd:COG0553 310 AKFAPGLRVlvldgTRERAKGANPFEDAD-------LVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVR 382
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 248 SLEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRKM--------CSDRPEQLNELIDECMLRRTAADVdLKHL 319
Cdd:COG0553 383 ALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERfarpiekgDEEALERLRRLLRPFLLRRTKEDV-LKDL 461
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 320 PEKHEYILFCAASPIQKHVHSEICDYM------------TGDALSLIFFARQLANHPKLLLDNLREKTEkskahkhspll 387
Cdd:COG0553 462 PEKTEETLYVELTPEQRALYEAVLEYLrrelegaegirrRGLILAALTRLRQICSHPALLLEEGAELSG----------- 530
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 388 lafdgahmprggvkESGKLTALVDMIKCFRLLQECTVIVSNYIETLDMIQQLCEYLNFKVLRLDGKTQVPDRQKLVRTFN 467
Cdd:COG0553 531 --------------RSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQ 596
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 468 DHRDPsNIFLLSTKAGGVGLNLIGASRLVLFDSDWNPANDQQAMARIWRDGQVRPCHIYRLITTGTIEEKMLQRQIKKTG 547
Cdd:COG0553 597 EGPEA-PVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRA 675
|
.
gi 392902167 548 L 548
Cdd:COG0553 676 L 676
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
93-309 |
4.98e-98 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 302.28 E-value: 4.98e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRLRRGSGKNGGGggAILADDMGLGKSLQTMAATWALLKGSKTAQQLANSCLIIVPSSLVNNWKAEF 172
Cdd:cd18004 1 LRPHQREGVQFLYDCLTGRRGYGGGG--AILADEMGLGKTLQAIALVWTLLKQGPYGKPTAKKALIVCPSSLVGNWKAEF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 173 DKWWRLMRfPAVIALTANDITTYQ-----STIKLMPYLVISYDLAQRHVEKL-KIIRFDVMVCDEGHKLKNLDGKLRKTL 246
Cdd:cd18004 79 DKWLGLRR-IKVVTADGNAKDVKAsldffSSASTYPVLIISYETLRRHAEKLsKKISIDLLICDEGHRLKNSESKTTKAL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 247 LSLEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRKMCS--------------------DRPEQLNELIDECM 306
Cdd:cd18004 158 NSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEepilrsrdpdaseedkelgaERSQELSELTSRFI 237
|
...
gi 392902167 307 LRR 309
Cdd:cd18004 238 LRR 240
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
96-367 |
1.64e-58 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 199.83 E-value: 1.64e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 96 HQKSGIQFIFDRLRrgsgknGGGGGAILADDMGLGKSLQTMAATWALLKGSKtaqQLANSCLIIVPSSLVNNWKAEFDKW 175
Cdd:pfam00176 1 YQIEGVNWMLSLEN------NLGRGGILADEMGLGKTLQTISLLLYLKHVDK---NWGGPTLIVVPLSLLHNWMNEFERW 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 176 WRLMRFPAVIALTANDITTYQSTIKLMPY----LVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEI 251
Cdd:pfam00176 72 VSPPALRVVVLHGNKRPQERWKNDPNFLAdfdvVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKT 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 252 PRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRK---------MCSDRPEQLNELIDECMLRRTAADVDlKHLPEK 322
Cdd:pfam00176 152 RNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNwfdrpiergGGKKGVSRLHKLLKPFLLRRTKKDVE-KSLPPK 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 392902167 323 HEYILFCAASPIQKHVH--------------SEICDYMTGDALSLIFFARQLANHPKLL 367
Cdd:pfam00176 231 VEYILFCRLSKLQRKLYqtfllkkdlnaiktGEGGREIKASLLNILMRLRKICNHPGLI 289
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
122-548 |
4.08e-58 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 213.12 E-value: 4.08e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAatwaLLKGSKTAQQLANSCLIIVPSSLVNNWKAEFDKWWRLMRfpAVIALTANDITTYQSTIKL 201
Cdd:PLN03142 192 ILADEMGLGKTLQTIS----LLGYLHEYRGITGPHMVVAPKSTLGNWMNEIRRFCPVLR--AVKFHGNPEERAHQREELL 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 202 MP----YLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVR 277
Cdd:PLN03142 266 VAgkfdVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLL 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 278 PSVFGSIVEFRKMCS-----DRPE---QLNELIDECMLRRTAADVDlKHLPEKHEYILFCAASPIQKHVHSEICDY---- 345
Cdd:PLN03142 346 PEIFSSAETFDEWFQisgenDQQEvvqQLHKVLRPFLLRRLKSDVE-KGLPPKKETILKVGMSQMQKQYYKALLQKdldv 424
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 346 --MTGDALSLIFFARQL---ANHPKLLldnlrektekSKAHKHSPLllaFDGAHMprggVKESGKLTALVDMIKCFRLLQ 420
Cdd:PLN03142 425 vnAGGERKRLLNIAMQLrkcCNHPYLF----------QGAEPGPPY---TTGEHL----VENSGKMVLLDKLLPKLKERD 487
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 421 ECTVIVSNYIETLDMIQQLCEYLNFKVLRLDGKTQVPDRQKLVRTFNDHRDPSNIFLLSTKAGGVGLNLIGASRLVLFDS 500
Cdd:PLN03142 488 SRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKFVFLLSTRAGGLGINLATADIVILYDS 567
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 392902167 501 DWNPANDQQAMARIWRDGQVRPCHIYRLITTGTIEEKMLQRQIKKTGL 548
Cdd:PLN03142 568 DWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLAL 615
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
93-281 |
1.01e-53 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 182.77 E-value: 1.01e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRLRRGSGkngggggAILADDMGLGKSLQTMAATWALLKGSKTAqqlaNSCLIIVPSSLVNNWKAEF 172
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPG-------GILADEMGLGKTLQAIAFLAYLLKEGKER----GPVLVVCPLSVLENWEREF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 173 DKWWRLMRfpaVIALTANDITTYQSTIKLMPY----LVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLS 248
Cdd:cd17919 70 EKWTPDLR---VVVYHGSQRERAQIRAKEKLDkfdvVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKA 146
|
170 180 190
....*....|....*....|....*....|...
gi 392902167 249 LEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVF 281
Cdd:cd17919 147 LRAKRRLLLTGTPLQNNLEELWALLDFLDPPFL 179
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
403-529 |
1.70e-52 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 177.67 E-value: 1.70e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 403 SGKLTALVDMIKCFRLLQECTVIVSNYIETLDMIQQLCEYLNFKVLRLDGKTQVPDRQKLVRTFNDHRDPsNIFLLSTKA 482
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDI-RVFLLSTKA 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 392902167 483 GGVGLNLIGASRLVLFDSDWNPANDQQAMARIWRDGQVRPCHIYRLI 529
Cdd:cd18793 89 GGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
93-290 |
6.24e-48 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 169.26 E-value: 6.24e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRLrrGSGKNGGGGGAILADDMGLGKSLQTMAATWALLK-GSKTAQQLANSCLIIVPSSLVNNWKAE 171
Cdd:cd18066 1 LRPHQREGIEFLYECV--MGMRVNERFGAILADEMGLGKTLQCISLIWTLLRqGPYGGKPVIKRALIVTPGSLVKNWKKE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 172 FDKWWRLMRFPAVIALTANDITTYQSTIkLMPYLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEI 251
Cdd:cd18066 79 FQKWLGSERIKVFTVDQDHKVEEFIASP-LYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTALTSLSC 157
|
170 180 190
....*....|....*....|....*....|....*....
gi 392902167 252 PRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRKM 290
Cdd:cd18066 158 ERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKV 196
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
93-309 |
1.15e-46 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 165.72 E-value: 1.15e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFD----RLRRGSGKngggggAILADDMGLGKSLQTMAATWALLKGSKTAQQLANSCLIIVPSSLVNNW 168
Cdd:cd18067 1 LRPHQREGVKFLYRcvtgRRIRGSHG------CIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIDKAIVVSPSSLVKNW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 169 KAEFDKWWRlmrfPAVIALTANDITTYQSTIKLM------------PYLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLK 236
Cdd:cd18067 75 ANELGKWLG----GRLQPLAIDGGSKKEIDRKLVqwasqqgrrvstPVLIISYETFRLHVEVLQKGEVGLVICDEGHRLK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 237 NLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRKMC--------------SDRP---EQLN 299
Cdd:cd18067 151 NSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFelpilkgrdadaseKERQlgeEKLQ 230
|
250
....*....|...
gi 392902167 300 ELI---DECMLRR 309
Cdd:cd18067 231 ELIsivNRCIIRR 243
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
93-290 |
4.84e-44 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 158.61 E-value: 4.84e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRLRRGSGKNGGGGGAILADDMGLGKSLQTMAATWALLKGSKTaqqlANSCLIIVPSSLVNNWKAEF 172
Cdd:cd18007 1 LKPHQVEGVRFLWSNLVGTDVGSDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPR----RSRPLVLCPASTLYNWEDEF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 173 DKWWRLMRFPAVIALTANDITTYQSTIKLMP-------YLVISYD----LAQRH----VEKLKIIRF------DVMVCDE 231
Cdd:cd18007 77 KKWLPPDLRPLLVLVSLSASKRADARLRKINkwhkeggVLLIGYElfrnLASNAttdpRLKQEFIAAlldpgpDLLVLDE 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 392902167 232 GHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRKM 290
Cdd:cd18007 157 GHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKK 215
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
93-310 |
1.81e-38 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 141.93 E-value: 1.81e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIfDRLRRGSGKngggggAILADDMGLGKSLQTMAatwaLLKGSKTaQQLANSCLIIVPSSLVNNWKAEF 172
Cdd:cd18012 5 LRPYQKEGFNWL-SFLRHYGLG------GILADDMGLGKTLQTLA----LLLSRKE-EGRKGPSLVVAPTSLIYNWEEEA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 173 DKW---WRLM-------RFPAVIALTANDIttyqstiklmpyLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKL 242
Cdd:cd18012 73 AKFapeLKVLvihgtkrKREKLRALEDYDL------------VITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKT 140
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392902167 243 RKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRKM---------CSDRPEQLNELIDECMLRRT 310
Cdd:cd18012 141 AKAVKALKADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRfakpiekdgDEEALEELKKLISPFILRRL 217
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
93-293 |
8.27e-37 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 138.28 E-value: 8.27e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRLrrgsgknGGGGGAILADDMGLGKSLQTMAATWALLKGSKTAQQLANS----------------C 156
Cdd:cd18005 1 LRDYQREGVEFMYDLY-------KNGRGGILGDDMGLGKTVQVIAFLAAVLGKTGTRRDRENNrprfkkkppassakkpV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 157 LIIVPSSLVNNWKAEFDKWwrlMRFPAVIALTANDITTYQSTIKLMPY--LVISYDLAQRHVEKLKIIRFDVMVCDEGHK 234
Cdd:cd18005 74 LIVAPLSVLYNWKDELDTW---GHFEVGVYHGSRKDDELEGRLKAGRLevVVTTYDTLRRCIDSLNSINWSAVIADEAHR 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 392902167 235 LKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRKMCSD 293
Cdd:cd18005 151 IKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSE 209
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
93-309 |
2.24e-32 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 125.18 E-value: 2.24e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQF---IFDRLRrgsgknggggGAILADDMGLGKSLQTMAATWALLKGSktaqqLANSCLIIVPSSLVNNWK 169
Cdd:cd18001 1 LYPHQREGVAWlwsLHDGGK----------GGILADDMGLGKTVQICAFLSGMFDSG-----LIKSVLVVMPTSLIPHWV 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 170 AEFDKWWRLMRF-----PAVIALTAND----------ITTYQSTIKLMPYLviSYDLAQRHVeklkiirFDVMVCDEGHK 234
Cdd:cd18001 66 KEFAKWTPGLRVkvfhgTSKKERERNLeriqrgggvlLTTYGMVLSNTEQL--SADDHDEFK-------WDYVILDEGHK 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 235 LKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRP-SVFGSIVEF--------------------RKMCSD 293
Cdd:cd18001 137 IKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFACNgSLLGTRKTFkmefenpitrgrdkdatqgeKALGSE 216
|
250
....*....|....*.
gi 392902167 294 RPEQLNELIDECMLRR 309
Cdd:cd18001 217 VAENLRQIIKPYFLRR 232
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
122-309 |
1.01e-31 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 123.13 E-value: 1.01e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAatwaLLKGSKTAQQLANSCLIIVPSSLVNNWKAEFDKWWRL-------------------MRFP 182
Cdd:cd17995 23 ILADEMGLGKTIQSIA----FLEHLYQVEGIRGPFLVIAPLSTIPNWQREFETWTDMnvvvyhgsgesrqiiqqyeMYFK 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 183 AVIALTANDIttYQSTIklmpyLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPM 262
Cdd:cd17995 99 DAQGRKKKGV--YKFDV-----LITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLTLEHKLLLTGTPL 171
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 392902167 263 QNDFEEFYSLLDFVRPSVFGSIVEF-RKMCS----DRPEQLNELIDECMLRR 309
Cdd:cd17995 172 QNNTEELWSLLNFLEPEKFPSSEEFlEEFGDlktaEQVEKLQALLKPYMLRR 223
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
93-309 |
5.49e-31 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 120.77 E-value: 5.49e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRLRRgsgkngggggAILADDMGLGKSLQTMAatwallkgskTAQQLANSC--LIIVPSSLVNNWKA 170
Cdd:cd18010 1 LLPFQREGVCFALRRGGR----------VLIADEMGLGKTVQAIA----------IAAYYREEWplLIVCPSSLRLTWAD 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 171 EFDKWWRLMRFPAVIALTANDITTYQSTIKLmpyLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSL- 249
Cdd:cd18010 61 EIERWLPSLPPDDIQVIVKSKDGLRDGDAKV---VIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLl 137
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392902167 250 -EIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRKMCSDRP---------------EQLNELIDECMLRR 309
Cdd:cd18010 138 kRAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRRYCAAKqggfgwdysgssnleELHLLLLATIMIRR 213
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
93-288 |
1.14e-30 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 120.76 E-value: 1.14e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFD----RLRRGSGKNGGGggAILADDMGLGKSLQTMAATWALLKGSKTAQqlANSCLIIVPSSLVNNW 168
Cdd:cd18068 1 LKPHQVDGVQFMWDccceSLKKTKKSPGSG--CILAHCMGLGKTLQVVTFLHTVLLCEKLEN--FSRVLVVCPLNTVLNW 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 169 KAEFDKWWRLMRFPAVIALtaNDITTYQS----TIKLMPY------LVISYDL--------AQRHVEKLKIIRF------ 224
Cdd:cd18068 77 LNEFEKWQEGLKDEEKIEV--NELATYKRpqerSYKLQRWqeeggvMIIGYDMyrilaqerNVKSREKLKEIFNkalvdp 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392902167 225 --DVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFR 288
Cdd:cd18068 155 gpDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFR 220
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
122-287 |
1.64e-30 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 120.17 E-value: 1.64e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAATWALLKgsktAQQLANSCLIIVPSSLVNNWKAEFDKWwrlmrFPAVIAL----TANDITTYQS 197
Cdd:cd17996 26 ILADEMGLGKTIQTISLITYLME----KKKNNGPYLVIVPLSTLSNWVSEFEKW-----APSVSKIvykgTPDVRKKLQS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 198 TIKLMPY--LVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEI-PRRLILTGTPMQNDFEEFYSLLD 274
Cdd:cd17996 97 QIRAGKFnvLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTYYHaRYRLLLTGTPLQNNLPELWALLN 176
|
170
....*....|...
gi 392902167 275 FVRPSVFGSIVEF 287
Cdd:cd17996 177 FLLPKIFKSCKTF 189
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
122-304 |
2.38e-30 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 119.80 E-value: 2.38e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAaTWALLKGSKTAQQLanscLIIVPSSLVNNWKAEFDKWwrlmrFPAVIAL----TAND------ 191
Cdd:cd18009 26 ILADEMGLGKTIQTIA-LLAHLRERGVWGPF----LVIAPLSTLPNWVNEFARF-----TPSVPVLlyhgTKEErerlrk 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 192 -ITTYQSTIKLMPYLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFY 270
Cdd:cd18009 96 kIMKREGTLQDFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELW 175
|
170 180 190
....*....|....*....|....*....|....*....
gi 392902167 271 SLLDFVRPSVFGSIVEFRKM-----CSDRPEQLNELIDE 304
Cdd:cd18009 176 SLLNFLLPDVFDDLSSFESWfdfssLSDNAADISNLSEE 214
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
93-316 |
7.53e-30 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 117.99 E-value: 7.53e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRLRRGSGKNGGGGG--AILADDMGLGKSLQTMAATWALLKGSKtaqqlANSCLIIVPSSLVNNWKA 170
Cdd:cd18069 1 LKPHQIGGIRFLYDNIIESLERYKGSSGfgCILAHSMGLGKTLQVISFLDVLLRHTG-----AKTVLAIVPVNTLQNWLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 171 EFDKWW-RLMRFPAV------IALTANDITTYQSTIKLMP-------YLVISYDLAQRHVEKlkiirfDVMVCDEGHKLK 236
Cdd:cd18069 76 EFNKWLpPPEALPNVrprpfkVFILNDEHKTTAARAKVIEdwvkdggVLLMGYEMFRLRPGP------DVVICDEGHRIK 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 237 NLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRKMcSDRPEQLNELIDEcmlrrTAADVDL 316
Cdd:cd18069 150 NCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNM-FERPILNGQCVDS-----TPQDVKL 223
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
93-288 |
8.41e-30 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 117.84 E-value: 8.41e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIfDRLRRGSGKngggggAILADDMGLGKSLQTMAATWALLKGSKTAQQLANSC-LIIVPSSLVNNWKAE 171
Cdd:cd17999 1 LRPYQQEGINWL-AFLNKYNLH------GILCDDMGLGKTLQTLCILASDHHKRANSFNSENLPsLVVCPPTLVGHWVAE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 172 FDKwwrlmRFP-AVIALTANDiTTYQSTIKLMPY------LVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRK 244
Cdd:cd17999 74 IKK-----YFPnAFLKPLAYV-GPPQERRRLREQgekhnvIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSK 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 392902167 245 TLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFR 288
Cdd:cd17999 148 AVKQLKANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQ 191
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
122-310 |
1.03e-29 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 117.42 E-value: 1.03e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAatwaLLKGSKTAQQLANSCLIIVPSSLVNNWKAEFDKWWRLMRFPAVIALTANDITTYQSTIKL 201
Cdd:cd17997 26 ILADEMGLGKTLQTIS----LLGYLKHYKNINGPHLIIVPKSTLDNWMREFKRWCPSLRVVVLIGDKEERADIIRDVLLP 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 202 MPYLVI--SYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRPS 279
Cdd:cd17997 102 GKFDVCitSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPD 181
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 392902167 280 VFGSIVEF-----RKMCSD----RPEQLNELIDECMLRRT 310
Cdd:cd17997 182 VFTSSEDFdewfnVNNCDDdnqeVVQRLHKVLRPFLLRRI 221
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
93-278 |
2.71e-29 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 115.11 E-value: 2.71e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRLRRGSGkngggggAILADDMGLGKSLQTmAATWALLKGSKtaqQLANSCLIIVPSSLVNNWKAEF 172
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVG-------GILGDEMGLGKTIQI-IAFLAALHHSK---LGLGPSLIVCPATVLKQWVKEF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 173 DKWWRLMRfpaVIALTANDITTYQSTIKLMPY---------------LVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKN 237
Cdd:cd18000 70 HRWWPPFR---VVVLHSSGSGTGSEEKLGSIErksqlirkvvgdggiLITTYEGFRKHKDLLLNHNWQYVILDEGHKIRN 146
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 392902167 238 LDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRP 278
Cdd:cd18000 147 PDAEITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
93-293 |
3.01e-28 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 113.22 E-value: 3.01e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRLRRGSGkngggggAILADDMGLGKSLQTMAatwaLLKGSKTAQQLANSCLIIVPSSLVNNWKAEF 172
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLN-------GILADEMGLGKTIQTIA----LLAHLACEKGNWGPHLIVVPTSVMLNWEMEF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 173 DKWwrlmrFPAVIALT---------------AND------ITTYQSTIKlmpylvisydlaQRHVEKLKiiRFDVMVCDE 231
Cdd:cd18003 70 KRW-----CPGFKILTyygsakerklkrqgwMKPnsfhvcITSYQLVVQ------------DHQVFKRK--KWKYLILDE 130
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392902167 232 GHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRKMCSD 293
Cdd:cd18003 131 AHNIKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSN 192
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
122-309 |
3.70e-28 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 112.83 E-value: 3.70e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAATWALLKgsktAQQLANSCLIIVPSSLVNNWKAEFDKWWRLMRFPAVIALTA--NDITTY---Q 196
Cdd:cd17993 24 ILADEMGLGKTVQTISFLSYLFH----SQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVIVYLGDIKsrDTIREYefyF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 197 STIKLMPY--LVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLD 274
Cdd:cd17993 100 SQTKKLKFnvLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNSLKELWALLH 179
|
170 180 190
....*....|....*....|....*....|....*....
gi 392902167 275 FVRPSVFGSIVEFRKMCSDRPE----QLNELIDECMLRR 309
Cdd:cd17993 180 FLMPGKFDIWEEFEEEHDEEQEkgiaDLHKELEPFILRR 218
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
93-309 |
9.69e-28 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 112.38 E-value: 9.69e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRlrrgsgknggggGAILADDMGLGKSLQT---MAAT--------WALLKGSKTAQQLANSC--LII 159
Cdd:cd18008 1 LLPYQKQGLAWMLPR------------GGILADEMGLGKTIQAlalILATrpqdpkipEELEENSSDPKKLYLSKttLIV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 160 VPSSLVNNWKAEFDKWWRLMRFPAVIALTANDITtyqSTIKLMPYLVI--SY----------------DLAQRHVEKLKI 221
Cdd:cd18008 69 VPLSLLSQWKDEIEKHTKPGSLKVYVYHGSKRIK---SIEELSDYDIVitTYgtlasefpknkkgggrDSKEKEASPLHR 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 222 IRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRKMCSDRP------ 295
Cdd:cd18008 146 IRWYRVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFskndrk 225
|
250
....*....|....*.
gi 392902167 296 --EQLNELIDECMLRR 309
Cdd:cd18008 226 alERLQALLKPILLRR 241
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
93-309 |
1.08e-27 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 111.38 E-value: 1.08e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRLrrgsgknGGGGGAILADDMGLGKSLQTMAATWaLLKGSktaQQLANSCLIIVPSSLVNNWKAEf 172
Cdd:cd18006 1 LRPYQLEGVNWLLQCR-------AEQHGCILGDEMGLGKTCQTISLLW-YLAGR---LKLLGPFLVLCPLSVLDNWKEE- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 173 dkwwrLMRF-PAVIALT-ANDI---TTYQSTIKLMP---YLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRK 244
Cdd:cd18006 69 -----LNRFaPDLSVITyMGDKekrLDLQQDIKSTNrfhVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHK 143
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392902167 245 TLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFG-----SIVEFRKMCSDRPEQLNEL---IDECMLRR 309
Cdd:cd18006 144 TLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEPNVFPkdkldDFIKAYSETDDESETVEELhllLQPFLLRR 216
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
121-281 |
5.05e-27 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 108.63 E-value: 5.05e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 121 AILADDMGLGKSLQTMAATWALLKGSKTAQQLansclIIVPSSLVNNWKAEFDKWW---------------RLMRFPAVI 185
Cdd:cd17998 22 GILADEMGLGKTIQVIAFLAYLKEIGIPGPHL-----VVVPSSTLDNWLREFKRWCpslkvepyygsqeerKHLRYDILK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 186 ALTANDI--TTYQstiklmpyLVISYDLAQRHvekLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQ 263
Cdd:cd17998 97 GLEDFDVivTTYN--------LATSNPDDRSF---FKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLTGTPLQ 165
|
170
....*....|....*...
gi 392902167 264 NDFEEFYSLLDFVRPSVF 281
Cdd:cd17998 166 NNLLELMSLLNFIMPKPF 183
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
93-309 |
1.20e-25 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 105.06 E-value: 1.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRLRrgsgkngggGGAILADDMGLGKSLQtMAATWALLKgsktAQQLANSCLIIVPSSLVNNWKAE- 171
Cdd:cd18011 1 PLPHQIDAVLRALRKPP---------VRLLLADEVGLGKTIE-AGLIIKELL----LRGDAKRVLILCPASLVEQWQDEl 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 172 FDKWWRlmRFPAVIALTANDITTYQSTIKLMPYLVI-SYDLAQRHVE---KLKIIRFDVMVCDEGHKLKNLDGKLRKTLL 247
Cdd:cd18011 67 QDKFGL--PFLILDRETAAQLRRLIGNPFEEFPIVIvSLDLLKRSEErrgLLLSEEWDLVVVDEAHKLRNSGGGKETKRY 144
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392902167 248 SL--EI----PRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRKMCSDRPEQLNElidecMLRR 309
Cdd:cd18011 145 KLgrLLakraRHVLLLTATPHNGKEEDFRALLSLLDPGRFAVLGRFLRLDGLREVLAKV-----LLRR 207
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
122-309 |
3.70e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 104.70 E-value: 3.70e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAATWALLKgsktAQQLANSCLIIVPSSLVNNWKAEFDKWWRLMRFPAVIA--LTANDITTYQ--- 196
Cdd:cd18054 43 ILADEMGLGKTIQTISFLSYLFH----QHQLYGPFLLVVPLSTLTSWQREFEIWAPEINVVVYIGdlMSRNTIREYEwih 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 197 STIKLMPY--LVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLD 274
Cdd:cd18054 119 SQTKRLKFnaLITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLH 198
|
170 180 190
....*....|....*....|....*....|....*....
gi 392902167 275 FVRPSVFGSIVEFR----KMCSDRPEQLNELIDECMLRR 309
Cdd:cd18054 199 FIMPEKFEFWEDFEedhgKGRENGYQSLHKVLEPFLLRR 237
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
121-322 |
3.79e-25 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 104.75 E-value: 3.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 121 AILADDMGLGKSLQTMAatwaLLKGSKTAQQLANSCLIIVPSSLVNNWKAEFDKWWRLMRFPAVIALTANDITTYQSTik 200
Cdd:cd18064 37 GILADEMGLGKTLQTIS----LLGYMKHYRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRAVCLIGDKDQRAAFVRDV-- 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 201 LMP----YLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFV 276
Cdd:cd18064 111 LLPgewdVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFL 190
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 392902167 277 RPSVFGSIVEF------RKMCSDRP--EQLNELIDECMLRRTAADVDlKHLPEK 322
Cdd:cd18064 191 LPDVFNSAEDFdswfdtNNCLGDQKlvERLHMVLRPFLLRRIKADVE-KSLPPK 243
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
121-289 |
4.00e-25 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 105.14 E-value: 4.00e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 121 AILADDMGLGKSLQTMAATWALLKgsktAQQLANSCLIIVPSSLVNNWKAEFDKWwrlmrFPAVIALTANDITTYQSTik 200
Cdd:cd18063 45 GILADEMGLGKTIQTIALITYLME----HKRLNGPYLIIVPLSTLSNWTYEFDKW-----APSVVKISYKGTPAMRRS-- 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 201 LMP--------YLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEI-PRRLILTGTPMQNDFEEFYS 271
Cdd:cd18063 114 LVPqlrsgkfnVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVaPRRILLTGTPLQNKLPELWA 193
|
170
....*....|....*...
gi 392902167 272 LLDFVRPSVFGSIVEFRK 289
Cdd:cd18063 194 LLNFLLPTIFKSCSTFEQ 211
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
93-309 |
1.78e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 102.44 E-value: 1.78e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFI-FDRLRRGSgkngggggAILADDMGLGKSLQTMAATWALLKGSktaqqLANSCLIIVPSSLVNNWKAE 171
Cdd:cd18060 1 LREYQLEGVNWLlFNWYNRQN--------CILADEMGLGKTIQSIAFLQEVYNVG-----IHGPFLVIAPLSTITNWERE 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 172 FDKWWRLMRFPAVIALTAND-ITTYQSTIK-----LMP------YLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLD 239
Cdd:cd18060 68 FNTWTEMNTIVYHGSLASRQmIQQYEMYCKdsrgrLIPgaykfdALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRN 147
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392902167 240 GKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRKMCSD-----RPEQLNELIDECMLRR 309
Cdd:cd18060 148 CKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDlkteeQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
121-309 |
1.87e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 101.36 E-value: 1.87e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 121 AILADDMGLGKSLQTMAATWALLKGSKTAQQLanscLIIVPSSLVNNWKAEFDKWwrlmrfpavialtAND---ITTYQS 197
Cdd:cd17994 22 TILADEMGLGKTIQTIVFLYSLYKEGHSKGPF----LVSAPLSTIINWEREFEMW-------------APDfyvVTYVGD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 198 TIKLMPYLVISYDLAQrhvekLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVR 277
Cdd:cd17994 85 HVLLTSYELISIDQAI-----LGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLT 159
|
170 180 190
....*....|....*....|....*....|....*..
gi 392902167 278 PSVFGSIVEFRKMCSD--RPEQ---LNELIDECMLRR 309
Cdd:cd17994 160 PERFNNLQGFLEEFADisKEDQikkLHDLLGPHMLRR 196
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
121-289 |
5.27e-24 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 101.66 E-value: 5.27e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 121 AILADDMGLGKSLQTMAATWALLKgsktAQQLANSCLIIVPSSLVNNWKAEFDKWwrlmrFPAVIALT------ANDITT 194
Cdd:cd18062 45 GILADEMGLGKTIQTIALITYLME----HKRINGPFLIIVPLSTLSNWVYEFDKW-----APSVVKVSykgspaARRAFV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 195 YQSTIKLMPYLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEI-PRRLILTGTPMQNDFEEFYSLL 273
Cdd:cd18062 116 PQLRSGKFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVaPRRLLLTGTPLQNKLPELWALL 195
|
170
....*....|....*.
gi 392902167 274 DFVRPSVFGSIVEFRK 289
Cdd:cd18062 196 NFLLPTIFKSCSTFEQ 211
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
404-518 |
4.08e-23 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 94.58 E-value: 4.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 404 GKLTALVDMIKCFRllQECTVIVSNYIETLDmIQQLCEYLNFKVLRLDGKTQVPDRQKLVRTFndhRDPSNIFLLSTKAG 483
Cdd:pfam00271 1 EKLEALLELLKKER--GGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDF---RKGKIDVLVATDVA 74
|
90 100 110
....*....|....*....|....*....|....*
gi 392902167 484 GVGLNLIGASRLVLFDSDWNPANDQQAMARIWRDG 518
Cdd:pfam00271 75 ERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
122-309 |
2.20e-22 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 96.42 E-value: 2.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAatwaLLKGSKTAQQLANSCLIIVPSSLVNNWKAEFDKWwrlmrFPAVIAL----TANDITTYQS 197
Cdd:cd18002 23 ILADEMGLGKTVQSIA----VLAHLAEEHNIWGPFLVIAPASTLHNWQQEISRF-----VPQFKVLpywgNPKDRKVLRK 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 198 TI--KLMPY-------LVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEE 268
Cdd:cd18002 94 FWdrKNLYTrdapfhvVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAE 173
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 392902167 269 FYSLLDFVRPSVFGSIVEFRKMCSDRPE---QLNELIDECMLRR 309
Cdd:cd18002 174 LWALLHFIMPTLFDSHDEFNEWFSKDIEshaENKTGLNEHQLKR 217
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
121-287 |
2.36e-22 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 96.63 E-value: 2.36e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 121 AILADDMGLGKSLQTMAatwaLLKGSKTAQQLANSCLIIVPSSLVNNWKAEFDKWWRLMRfpAVIALTANDITTYQSTIK 200
Cdd:cd18065 37 GILADEMGLGKTLQTIA----LLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLR--AVCLIGDKDARAAFIRDV 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 201 LMP----YLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFV 276
Cdd:cd18065 111 MMPgewdVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFL 190
|
170
....*....|.
gi 392902167 277 RPSVFGSIVEF 287
Cdd:cd18065 191 LPDVFNSADDF 201
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
122-309 |
1.94e-21 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 93.57 E-value: 1.94e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAATWAL-LKGsktaqqLANSCLIIVPSSLVNNWKAEFDKWWRLmrfpAVIALTANDITTYQSTIK 200
Cdd:cd18058 23 ILADEMGLGKTIQSITFLSEIfLMG------IRGPFLIIAPLSTITNWEREFRTWTEM----NAIVYHGSQISRQMIQQY 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 201 LMPY----------------LVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQN 264
Cdd:cd18058 93 EMYYrdeqgnplsgifkfqvVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQN 172
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 392902167 265 DFEEFYSLLDFVRPSVFGSIVEFRKMCSD-----RPEQLNELIDECMLRR 309
Cdd:cd18058 173 SVEELFSLLNFLEPSQFPSETTFLEEFGDlkteeQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
122-309 |
2.86e-21 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 93.15 E-value: 2.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAATWALLKGSKTAQQLanscLIIVPSSLVNNWKAEFDKWwrLMRFPAVI---------ALTANDI 192
Cdd:cd18055 23 ILADEMGLGKTIQTIVFLYSLYKEGHTKGPF----LVSAPLSTIINWEREFQMW--APDFYVVTytgdkdsraIIRENEF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 193 TTYQSTIK--------------LMPYLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILT 258
Cdd:cd18055 97 SFDDNAVKggkkafkmkreaqvKFHVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLT 176
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 392902167 259 GTPMQNDFEEFYSLLDFVRPSVF----GSIVEFRKMC-SDRPEQLNELIDECMLRR 309
Cdd:cd18055 177 GTPLQNNLEELFHLLNFLTPERFnnleGFLEEFADISkEDQIKKLHDLLGPHMLRR 232
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
93-279 |
3.64e-21 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 92.17 E-value: 3.64e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRLRRgsgkngggggAILADDMGLGKSLQTMAATWALLKGSKTAQqlansCLIIVP-SSLVNNWKAE 171
Cdd:smart00487 9 LRPYQKEAIEALLSGLRD----------VILAAPTGSGKTLAALLPALEALKRGKGGR-----VLVLVPtRELAEQWAEE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 172 FDKWWRLMRFPAVIALTANDITTYQSTIKLMPY--LVISYDLAQRHVEK--LKIIRFDVMVCDEGHKLKNLD--GKLRKT 245
Cdd:smart00487 74 LKKLGPSLGLKVVGLYGGDSKREQLRKLESGKTdiLVTTPGRLLDLLENdkLSLSNVDLVILDEAHRLLDGGfgDQLEKL 153
|
170 180 190
....*....|....*....|....*....|....*...
gi 392902167 246 LLSLE-IPRRLILTGTP---MQNDFEEFYSLLDFVRPS 279
Cdd:smart00487 154 LKLLPkNVQLLLLSATPpeeIENLLELFLNDPVFIDVG 191
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
122-309 |
3.68e-20 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 90.12 E-value: 3.68e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAATWALLKGSKTAqqlaNSCLIIVPSSLVNNWKAEFDKWW--------------RLMRFPAVIAL 187
Cdd:cd18057 23 ILADEMGLGKTVQTIVFLYSLYKEGHSK----GPYLVSAPLSTIINWEREFEMWApdfyvvtytgdkesRSVIRENEFSF 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 188 TANDITTYQSTIKL-------MPYLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGT 260
Cdd:cd18057 99 EDNAIRSGKKVFRMkkeaqikFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGT 178
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 392902167 261 PMQNDFEEFYSLLDFVRPSVF----GSIVEFRKMC-SDRPEQLNELIDECMLRR 309
Cdd:cd18057 179 PLQNNLEELFHLLNFLTPERFnnleGFLEEFADISkEDQIKKLHDLLGPHMLRR 232
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
122-309 |
4.14e-20 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 90.22 E-value: 4.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAATwallkgsktaqqLANSCLIIVPSSLVNNWKAEFDKWWR------LMRFPAVIALTANDITTY 195
Cdd:cd18071 52 ILADDMGLGKTLTTISLI------------LANFTLIVCPLSVLSNWETQFEEHVKpgqlkvYTYHGGERNRDPKLLSKY 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 196 QstIKLMPYLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDF 275
Cdd:cd18071 120 D--IVLTTYNTLASDFGAKGDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSF 197
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 392902167 276 VR------PSVFGSIVEfRKMCSDRP---EQLNELIDECMLRR 309
Cdd:cd18071 198 LHlkpfsnPEYWRRLIQ-RPLTMGDPtglKRLQVLMKQITLRR 239
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
122-289 |
1.79e-19 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 88.18 E-value: 1.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAATWALLKgsktAQQLANSCLIIVPSSLVNNWKAEFDKWWRLMRfpAVIAL----TANDITTYQ- 196
Cdd:cd18053 43 ILADEMGLGKTIQTISFLNYLFH----EHQLYGPFLLVVPLSTLTSWQREIQTWAPQMN--AVVYLgdinSRNMIRTHEw 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 197 ---STIKL-MPYLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSL 272
Cdd:cd18053 117 mhpQTKRLkFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSL 196
|
170
....*....|....*..
gi 392902167 273 LDFVRPSVFGSIVEFRK 289
Cdd:cd18053 197 LHFIMPEKFSSWEDFEE 213
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
122-309 |
6.10e-19 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 86.66 E-value: 6.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAATWALLKGSKTAQQLanscLIIVPSSLVNNWKAEFDKWWRLMRFPAVIA-------LTANDITT 194
Cdd:cd18056 23 ILADEMGLGKTVQTAVFLYSLYKEGHSKGPF----LVSAPLSTIINWEREFEMWAPDMYVVTYVGdkdsraiIRENEFSF 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 195 YQSTIK--------------LMPYLVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGT 260
Cdd:cd18056 99 EDNAIRggkkasrmkkeasvKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGT 178
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 392902167 261 PMQNDFEEFYSLLDFVRPSVF----GSIVEFRKMC-SDRPEQLNELIDECMLRR 309
Cdd:cd18056 179 PLQNNLEELFHLLNFLTPERFhnleGFLEEFADIAkEDQIKKLHDMLGPHMLRR 232
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
434-518 |
1.47e-18 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 80.72 E-value: 1.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 434 DMIQQLCEYLNFKVLRLDGKTQVPDRQKLVRTFNDHRdpsNIFLLSTKAGGVGLNLIGASRLVLFDSDWNPANDQQAMAR 513
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGK---IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGR 77
|
....*
gi 392902167 514 IWRDG 518
Cdd:smart00490 78 AGRAG 82
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
122-309 |
2.26e-18 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 84.70 E-value: 2.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAATWAL-LKGsktaqqLANSCLIIVPSSLVNNWKAEFDKWWRLmrfpAVIALTANDITTYQSTIK 200
Cdd:cd18059 23 ILADEMGLGKTIQSITFLYEIyLKG------IHGPFLVIAPLSTIPNWEREFRTWTEL----NVVVYHGSQASRRTIQLY 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 201 LMPY----------------LVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQN 264
Cdd:cd18059 93 EMYFkdpqgrvikgsykfhaIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQN 172
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 392902167 265 DFEEFYSLLDFVRPSVFGSIVEFRKMCSD-----RPEQLNELIDECMLRR 309
Cdd:cd18059 173 TVEELFSLLHFLEPSRFPSETTFMQEFGDlkteeQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
122-309 |
2.51e-16 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 78.51 E-value: 2.51e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 122 ILADDMGLGKSLQTMAATWALLKGSktaqqLANSCLIIVPSSLVNNWKAEFDKWWRLMRFPAVIALTANDITTY------ 195
Cdd:cd18061 23 ILADEMGLGKTIQSITFLYEILLTG-----IRGPFLIIAPLSTIANWEREFRTWTDLNVVVYHGSLISRQMIQQyemyfr 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 196 --QSTIKLMPY----LVISYDLAQRHVEKLKIIRFDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEF 269
Cdd:cd18061 98 dsQGRIIRGAYrfqaIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEEL 177
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 392902167 270 YSLLDFVRPSVFGSIVEFRKMCSD-----RPEQLNELIDECMLRR 309
Cdd:cd18061 178 FSLLHFLEPLRFPSESTFMQEFGDlkteeQVQKLQAILKPMMLRR 222
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
93-309 |
5.41e-16 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 77.91 E-value: 5.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRLRRGSGKngggggAILADDMGLGKSLQTMAATWALLKG----------------SKTAQQLANSC 156
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRG------GILADDMGLGKTLTMIALILAQKNTqnrkeeekekalteweSKKDSTLVPSA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 157 --LIIVPSSLVNNWKAEFDKWWRLMRFPAVIALTAN--DITTYQSTIKLmpyLVISYDLAQRHVEKLKI---------IR 223
Cdd:cd18072 75 gtLVVCPASLVHQWKNEVESRVASNKLRVCLYHGPNreRIGEVLRDYDI---VITTYSLVAKEIPTYKEesrssplfrIA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 224 FDVMVCDEGHKLKNLDGKLRKTLLSLEIPRRLILTGTPMQNDFEEFYSLLDFVRPSVFGSIVEFRKMCSDRP----EQLN 299
Cdd:cd18072 152 WARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDDLKVWKKQVDNKSrkggERLN 231
|
250
....*....|
gi 392902167 300 ELIDECMLRR 309
Cdd:cd18072 232 ILTKSLLLRR 241
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
93-274 |
2.51e-11 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 63.91 E-value: 2.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRLRrgsgknggggGAILADdMGLGKSLQTMAATWALLKGSKTAQqlansCLIIVPSSLV-NNWKAE 171
Cdd:cd18013 1 PHPYQKVAINFIIEHPY----------CGLFLD-MGLGKTVTTLTALSDLQLDDFTRR-----VLVIAPLRVArSTWPDE 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 172 FDKWWRLmrfpavialtanDITTYQSTI----KLMPYL-------VISYDLAQRHVEKLKI-IRFDVMVCDEGHKLKNLD 239
Cdd:cd18013 65 VEKWNHL------------RNLTVSVAVgterQRSKAAntpadlyVINRENLKWLVNKSGDpWPFDMVVIDELSSFKSPR 132
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 392902167 240 GKLRKTLLSL--EIPRRLILTGTPMQNDFEEFYS---LLD 274
Cdd:cd18013 133 SKRFKALRKVrpVIKRLIGLTGTPSPNGLMDLWAqiaLLD 172
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
128-261 |
7.21e-09 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 55.00 E-value: 7.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 128 GLGKSLQTMAATWALLKGSktaqqlansCLIIVPS-SLVNNWKAEFDKW---WRLMRFPAVIALTAND----ITTYQSTI 199
Cdd:cd17926 28 GSGKTLTALALIAYLKELR---------TLIVVPTdALLDQWKERFEDFlgdSSIGLIGGGKKKDFDDanvvVATYQSLS 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392902167 200 KLMpylvisydlaqrHVEKLKIIRFDVMVCDEGHklkNLDGK-LRKTLLSLEIPRRLILTGTP 261
Cdd:cd17926 99 NLA------------EEEKDLFDQFGLLIVDEAH---HLPAKtFSEILKELNAKYRLGLTATP 146
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
89-576 |
3.47e-08 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 56.57 E-value: 3.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 89 FARHLRPHQKSGIQFIFDRLRRgsgkngGGGGAILADDMGLGKSLqtMAATWA--LLKGSKTaqqlanscLIIVPS-SLV 165
Cdd:COG1061 77 TSFELRPYQQEALEALLAALER------GGGRGLVVAPTGTGKTV--LALALAaeLLRGKRV--------LVLVPRrELL 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 166 NNWKAEFDKWWRLmrfpAVIALTANDITTyqstiklmPYLVISYDLAQRHVEKLKII-RFDVMVCDEGHKLknLDGKLRK 244
Cdd:COG1061 141 EQWAEELRRFLGD----PLAGGGKKDSDA--------PITVATYQSLARRAHLDELGdRFGLVIIDEAHHA--GAPSYRR 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 245 TLLSLEIPRRLILTGTP----MQNDFEEFYslldfvrpsvFGSIVEFRkmcsdrpeqLNELIDECMLRrtaadvdlkhlp 320
Cdd:COG1061 207 ILEAFPAAYRLGLTATPfrsdGREILLFLF----------DGIVYEYS---------LKEAIEDGYLA------------ 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 321 eKHEYIlfcaasPIQKHVHSEICDYMTGDAlsliFFARQLANHPKLLLDNLREKTEKSKAHKHsplllafdgahmprggv 400
Cdd:COG1061 256 -PPEYY------GIRVDLTDERAEYDALSE----RLREALAADAERKDKILRELLREHPDDRK----------------- 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 401 kesgkltalvdmikcfrllqecTVIVSNYIETLDMIQQLCEYLNFKVLRLDGKTQVPDRQKLVRTFNDHRDPsniFLLST 480
Cdd:COG1061 308 ----------------------TLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELR---ILVTV 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 481 KAGGVGLNLIGASRLVLFDSDWNPANDQQAMARIWRDGQV-RPCHIYRLITTGT-IEEKMLQRQIKKTGLGCVIDAIEVG 558
Cdd:COG1061 363 DVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGkEDALVYDFVGNDVpVLEELAKDLRDLAGYRVEFLDEEES 442
|
490
....*....|....*...
gi 392902167 559 DTIATFTDEDLKDIFTFT 576
Cdd:COG1061 443 EELALLIAVKPALEVKGE 460
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
93-308 |
4.47e-05 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 45.80 E-value: 4.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIQFIFDRlrrgsgknggggGAILADDMGLGKSLQTMA---ATWAlLKGSKTAQQL----------------- 152
Cdd:cd18070 1 LLPYQRRAVNWMLVP------------GGILADEMGLGKTVEVLAlilLHPR-PDNDLDAADDdsdemvccpdclvaetp 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 153 --ANSCLIIVPSSLVNNWKAEFDKWWRlmrfPAVIALTANDITTYQSTIKLMPYLVISYDLAqrhVEKLKIIRFDVMVCD 230
Cdd:cd18070 68 vsSKATLIVCPSAILAQWLDEINRHVP----SSLKVLTYQGVKKDGALASPAPEILAEYDIV---VTTYDVLRTELHYAE 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 231 EGHKLKNLDGKLRKT-----LLSLE-------------------------IPR--RLILTGTPMQNDFEEFYSLLDFVRP 278
Cdd:cd18070 141 ANRSNRRRRRQKRYEappspLVLVEwwrvcldeaqmvesstskaaemarrLPRvnRWCVSGTPIQRGLDDLFGLLSFLGV 220
|
250 260 270
....*....|....*....|....*....|....*.
gi 392902167 279 SVFGSIVEFRKM------CSDRPEQLNELIDECMLR 308
Cdd:cd18070 221 EPFCDSDWWARVlirpqgRNKAREPLAALLKELLWR 256
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
93-261 |
7.99e-04 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 40.73 E-value: 7.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 93 LRPHQKSGIqfifDRLRRGSGKNGGGGGAILAddMGLGKSLQTMAATWALLKgsktaQQLANSCLIIVPS-SLVNNWKAE 171
Cdd:pfam04851 4 LRPYQIEAI----ENLLESIKNGQKRGLIVMA--TGSGKTLTAAKLIARLFK-----KGPIKKVLFLVPRkDLLEQALEE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 172 FDKWwRLMRFPAVIALTANDITTYQSTIKLmpyLVISYDLAQRHV----EKLKIIRFDVMVCDEGHKLknLDGKLRKTLL 247
Cdd:pfam04851 73 FKKF-LPNYVEIGEIISGDKKDESVDDNKI---VVTTIQSLYKALelasLELLPDFFDVIIIDEAHRS--GASSYRNILE 146
|
170
....*....|....
gi 392902167 248 SLEIPRRLILTGTP 261
Cdd:pfam04851 147 YFKPAFLLGLTATP 160
|
|
| PRK04914 |
PRK04914 |
RNA polymerase-associated protein RapA; |
123-263 |
7.41e-03 |
|
RNA polymerase-associated protein RapA;
Pssm-ID: 235319 [Multi-domain] Cd Length: 956 Bit Score: 39.82 E-value: 7.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 123 LADDMGLGKslqTMAAtwallkGSKTAQQL----ANSCLIIVPSSLVNNWKAE-----------FDkwwrLMRFPAVIAL 187
Cdd:PRK04914 174 LADEVGLGK---TIEA------GMIIHQQLltgrAERVLILVPETLQHQWLVEmlrrfnlrfslFD----EERYAEAQHD 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902167 188 TANDITTYQstiklmpyLVI-SYDLAQRH---VEKLKIIRFDVMVCDEGHKL------KNLDGKLRKTlLSLEIPRRLIL 257
Cdd:PRK04914 241 ADNPFETEQ--------LVIcSLDFLRRNkqrLEQALAAEWDLLVVDEAHHLvwseeaPSREYQVVEQ-LAEVIPGVLLL 311
|
....*.
gi 392902167 258 TGTPMQ 263
Cdd:PRK04914 312 TATPEQ 317
|
|
| |
