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Conserved domains on  [gi|392921320|ref|NP_001256466|]
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Nidogen [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G2F smart00682
G2 nidogen domain and fibulin;
398-629 2.48e-101

G2 nidogen domain and fibulin;


:

Pssm-ID: 214774  Cd Length: 227  Bit Score: 323.24  E-value: 2.48e-101
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320    398 PKGEPQRISGSFEGVINRI--PI--DKTELHTFATSTDGNVHTAVSKIPSDLGHPLRFLYSIGGVMGWLFADVQSPNVyN 473
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVGefPVafENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAV-N 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320    474 GFQLTGGLFNRTVALHIEQNYYVTIKQEFSGRNIHDYFKSHLFVSGTLPDIAPGSEVIFPDYEEEYVRERRG-YLTSKAA 552
Cdd:smart00682   80 GFQLTGGVFTRETEVTFAGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTGPGvLTTSSTR 159

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392921320    553 FDVIvrdggNVQTYRMSVDQQITFEECPNKEFDRDHSMKLHVKRINVVYNDDEGVVRYGAKNfatrSVGPAVSAPSG 629
Cdd:smart00682  160 EYTV-----DNQTHSYTVDQTITFEECQHRDAFPPTTQQLHVSSVFVDYNDEERVLRFAAHN----SVGPGDESNQC 227
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
93-232 6.78e-40

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


:

Pssm-ID: 214712  Cd Length: 152  Bit Score: 145.26  E-value: 6.78e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320     93 VFYVPVT---SGVIDYRVSsDDQGLLTKLTQDVKQVFADAVEFHGLQAVIITWTQIENAEK---DGPASFQLAIVSDGIS 166
Cdd:smart00539    1 PFWADADtegTGKVYYRET-TDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSqssDGTNTFQAVLATDGSR 79

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392921320    167 TYAIFRYESLPWSSSM------GYYAQAGFVRSIGKI-QTNVNSGGPDVKELVNLSNNQFGNFFIFRVSGSAI 232
Cdd:smart00539   80 TYAIFLYPSLGWTSDTtaggddGVRARAGFNGGDGTFsYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1262-1456 9.82e-14

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 269  Bit Score: 73.12  E-value: 9.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1262 PVGIDFDCKEEKIVwSDMSGHSIRTSSLNGTEHKSY-----FNKELSSPEGIAVDwSSRNVYYADSMNDEIGVASLNGKF 1336
Cdd:cd05819    57 PAGVAVDSDGNLYV-ADTGNHRIQKFDPDGNFLASFggsgdGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEF 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1337 KKSLVTEG-----LVNPRSVVLDLYGrHLYYSDW--HRenpyIGRVDMDGKNNRVFLNEDVHL-----PNGLTIlpNRRE 1404
Cdd:cd05819   135 LTTFGSGGsgpgqFNGPTGVAVDSDG-NIYVADTgnHR----IQVFDPDGNFLTTFGSTGTGPgqfnyPTGIAV--DSDG 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392921320 1405 LCWV-DAGNHRlscIQY--------NGAGRR-TVFSSLQYPFGLTHDEEQKFYWTDWKDNRI 1456
Cdd:cd05819   208 NIYVaDSGNNR---VQVfdpdgagfGGNGNFlGSDGQFNRPSGLAVDSDGNLYVADTGNNRI 266
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 712-747 2.30e-11

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 59.53  E-value: 2.30e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 392921320   712 CQRGDHNCDQHAKCTNRPGSFSCQCLQGYQGDGRSC 747
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1496-1520 2.59e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 2.59e-05
                           10        20
                   ....*....|....*....|....*
gi 392921320  1496 CSEDNGGCQHLCLPGQNGAVCECPD 1520
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1185-1221 3.97e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 3.97e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 392921320  1185 CLDDRSLCDENADCVPgEAGHYVCNCHYGYHGDGRSC 1221
Cdd:pfam12947    1 CSDNNGGCHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
EGF_3 super family cl48154
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 841-870 1.64e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


The actual alignment was detected with superfamily member pfam12947:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.58  E-value: 1.64e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 392921320   841 CDVNAECmpEPSGGS-ECVCKAGFSGNGVTC 870
Cdd:pfam12947    8 CHPNATC--TNTGGSfTCTCNDGYTGDGVTC 36
EGF_3 super family cl48154
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1148-1179 2.01e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


The actual alignment was detected with superfamily member pfam12947:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.19  E-value: 2.01e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 392921320  1148 NCSIHAYCaqNPTSGAYQCKCNAGYNGNGHLC 1179
Cdd:pfam12947    7 GCHPNATC--TNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 super family cl48154
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 368-396 3.04e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


The actual alignment was detected with superfamily member pfam12947:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.81  E-value: 3.04e-03
                           10        20
                   ....*....|....*....|....*....
gi 392921320   368 CHANSVCQDFEGGFCCNCDTGFYGNGKEC 396
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
G2F smart00682
G2 nidogen domain and fibulin;
398-629 2.48e-101

G2 nidogen domain and fibulin;


Pssm-ID: 214774  Cd Length: 227  Bit Score: 323.24  E-value: 2.48e-101
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320    398 PKGEPQRISGSFEGVINRI--PI--DKTELHTFATSTDGNVHTAVSKIPSDLGHPLRFLYSIGGVMGWLFADVQSPNVyN 473
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVGefPVafENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAV-N 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320    474 GFQLTGGLFNRTVALHIEQNYYVTIKQEFSGRNIHDYFKSHLFVSGTLPDIAPGSEVIFPDYEEEYVRERRG-YLTSKAA 552
Cdd:smart00682   80 GFQLTGGVFTRETEVTFAGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTGPGvLTTSSTR 159

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392921320    553 FDVIvrdggNVQTYRMSVDQQITFEECPNKEFDRDHSMKLHVKRINVVYNDDEGVVRYGAKNfatrSVGPAVSAPSG 629
Cdd:smart00682  160 EYTV-----DNQTHSYTVDQTITFEECQHRDAFPPTTQQLHVSSVFVDYNDEERVLRFAAHN----SVGPGDESNQC 227
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 400-619 5.57e-85

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


Pssm-ID: 238158  Cd Length: 224  Bit Score: 277.27  E-value: 5.57e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320  400 GEPQRISGSFEGVIN----RIPIDKTELHTFATSTDGNVHTAVSKIPSDLGHPLRFLYSIGGVMGWLFAdVQSPNVYNGF 475
Cdd:cd00255     1 GIPQRVNGKVSGNINvgqsPVEFGDADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFA-LEQGGAKNGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320  476 QLTGGLFNRTVALHIE-QNYYVTIKQEFSGRNIHDYFKSHLFVSGTLPDIAPGSEVIFPDYEEEYVRERRGYLTSKAAFD 554
Cdd:cd00255    80 SLTGGEFTRQAEVTFYtGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPGVLTSSSTRE 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392921320  555 VIVRDGGNVQTYRMSVDQQITFEECPNKEFDRDHSMKLHVKRINVVYNDDEGVVRYGAKNFATRS 619
Cdd:cd00255   160 YTVDEGGESQTLSYQWNQTITYEECPHDDEAAPDLQQLLVARIFALYNPEEEILRFAITNSIGPG 224
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 400-583 7.72e-66

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


Pssm-ID: 462175  Cd Length: 184  Bit Score: 220.54  E-value: 7.72e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320   400 GEPQRISGSFEGVINRIPIDKTELHTFATSTDGNVHTAVSKIPSDLGHPLRFLYSIGGVMGWLFAdVQSPNVYNGFQLTG 479
Cdd:pfam07474    1 GVPQRVNGKVSGTINGVEFGDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFA-LEQGGAKNGFSLTG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320   480 GLFNRTVALHIEQ-NYYVTIKQEFSGRNIHDYFKSHLFVSGTLPDIAPGSEVIFPDYEEEYVRERRGYLTSKAAFDVIVR 558
Cdd:pfam07474   80 GVFNRTAEVTFPPtGERLTITQEFRGLDEDGHLVVDTVISGTVPQVPAGSTVIIEDYTELYQYTGPGELTSSSTRTYTVD 159

                          170       180
                   ....*....|....*....|....*
gi 392921320   559 DGGNVQTYRMSVDQQITFEECPNKE 583
Cdd:pfam07474  160 GEGNTRTISYTVNQTITYQECRHAE 184
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
93-232 6.78e-40

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 145.26  E-value: 6.78e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320     93 VFYVPVT---SGVIDYRVSsDDQGLLTKLTQDVKQVFADAVEFHGLQAVIITWTQIENAEK---DGPASFQLAIVSDGIS 166
Cdd:smart00539    1 PFWADADtegTGKVYYRET-TDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSqssDGTNTFQAVLATDGSR 79

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392921320    167 TYAIFRYESLPWSSSM------GYYAQAGFVRSIGKI-QTNVNSGGPDVKELVNLSNNQFGNFFIFRVSGSAI 232
Cdd:smart00539   80 TYAIFLYPSLGWTSDTtaggddGVRARAGFNGGDGTFsYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1262-1456 9.82e-14

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 73.12  E-value: 9.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1262 PVGIDFDCKEEKIVwSDMSGHSIRTSSLNGTEHKSY-----FNKELSSPEGIAVDwSSRNVYYADSMNDEIGVASLNGKF 1336
Cdd:cd05819    57 PAGVAVDSDGNLYV-ADTGNHRIQKFDPDGNFLASFggsgdGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEF 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1337 KKSLVTEG-----LVNPRSVVLDLYGrHLYYSDW--HRenpyIGRVDMDGKNNRVFLNEDVHL-----PNGLTIlpNRRE 1404
Cdd:cd05819   135 LTTFGSGGsgpgqFNGPTGVAVDSDG-NIYVADTgnHR----IQVFDPDGNFLTTFGSTGTGPgqfnyPTGIAV--DSDG 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392921320 1405 LCWV-DAGNHRlscIQY--------NGAGRR-TVFSSLQYPFGLTHDEEQKFYWTDWKDNRI 1456
Cdd:cd05819   208 NIYVaDSGNNR---VQVfdpdgagfGGNGNFlGSDGQFNRPSGLAVDSDGNLYVADTGNNRI 266
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 712-747 2.30e-11

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 59.53  E-value: 2.30e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 392921320   712 CQRGDHNCDQHAKCTNRPGSFSCQCLQGYQGDGRSC 747
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1338-1381 7.53e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 7.53e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 392921320   1338 KSLVTEGLVNPRSVVLDLYGRHLYYSDWHRenPYIGRVDMDGKN 1381
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTN 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
708-748 1.64e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.64e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 392921320    708 DLDECQRGdHNCDQHAKCTNRPGSFSCQCLQGYQgDGRSCI 748
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1262-1456 3.78e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 53.48  E-value: 3.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1262 PVGIDFDckEEKIVW-SDMSGHSIRtsSLNGTEHK-SYF--NKELSSPEGIAVDwSSRNVYYADSMNDEIGVASL-NGKF 1336
Cdd:COG4257    61 PHGIAVD--PDGNLWfTDNGNNRIG--RIDPKTGEiTTFalPGGGSNPHGIAFD-PDGNLWFTDQGGNRIGRLDPaTGEV 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1337 KKSLVTEGLVNPRSVVLDLYGRhLYYSDWhrENPYIGRVDMDGKNNRVF-LNEDVHLPNGLTILPNRReLCWVDAGNHRL 1415
Cdd:COG4257   136 TEFPLPTGGAGPYGIAVDPDGN-LWVTDF--GANAIGRIDPDTGTLTEYaLPTPGAGPRGLAVDPDGN-LWVADTGSGRI 211

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 392921320 1416 SciQYN---GAGRRTVFSSLQY-PFGLTHDEEQKFYWTDWKDNRI 1456
Cdd:COG4257   212 G--RFDpktGTVTEYPLPGGGArPYGVAVDGDGRVWFAESGANRI 254
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 155-227 5.10e-07

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 49.21  E-value: 5.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320   155 SFQLAIVSDGISTYAIFRYES--LPW---SSSMGYY------AQAGFvrSIGKIQTNV----NSGGPDVKELVNLSN-NQ 218
Cdd:pfam06119    3 TFQAVLATDGSGSFAIFNYPDggIQWttgKASGGTNglggtpAQAGF--SAGDGDGRYyelpGSGTDSIRNLTETSNvGV 80


                   ....*....
gi 392921320   219 FGnFFIFRV 227
Cdd:pfam06119   81 PG-RWVFRI 88
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 708-748 2.22e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.22e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 392921320  708 DLDECQRGdHNCDQHAKCTNRPGSFSCQCLQGYQgdGRSCI 748
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYT--GRNCE 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1496-1520 2.59e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 2.59e-05
                           10        20
                   ....*....|....*....|....*
gi 392921320  1496 CSEDNGGCQHLCLPGQNGAVCECPD 1520
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1185-1221 3.97e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 3.97e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 392921320  1185 CLDDRSLCDENADCVPgEAGHYVCNCHYGYHGDGRSC 1221
Cdd:pfam12947    1 CSDNNGGCHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1272-1312 7.79e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.68  E-value: 7.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 392921320  1272 EKIVWSDMS-GHSIRTSSLNGTEHKSYFNKELSSPEGIAVDW 1312
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 841-870 1.64e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.58  E-value: 1.64e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 392921320   841 CDVNAECmpEPSGGS-ECVCKAGFSGNGVTC 870
Cdd:pfam12947    8 CHPNATC--TNTGGSfTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1148-1179 2.01e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.19  E-value: 2.01e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 392921320  1148 NCSIHAYCaqNPTSGAYQCKCNAGYNGNGHLC 1179
Cdd:pfam12947    7 GCHPNATC--TNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 368-396 3.04e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.81  E-value: 3.04e-03
                           10        20
                   ....*....|....*....|....*....
gi 392921320   368 CHANSVCQDFEGGFCCNCDTGFYGNGKEC 396
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
G2F smart00682
G2 nidogen domain and fibulin;
398-629 2.48e-101

G2 nidogen domain and fibulin;


Pssm-ID: 214774  Cd Length: 227  Bit Score: 323.24  E-value: 2.48e-101
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320    398 PKGEPQRISGSFEGVINRI--PI--DKTELHTFATSTDGNVHTAVSKIPSDLGHPLRFLYSIGGVMGWLFADVQSPNVyN 473
Cdd:smart00682    1 AEGGPQRVSGSVSGVINVGefPVafENADLHSYVVSSEGRAYTAISNIPSPLGAALRPLVPIGGTIGWLFAKEQGGAV-N 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320    474 GFQLTGGLFNRTVALHIEQNYYVTIKQEFSGRNIHDYFKSHLFVSGTLPDIAPGSEVIFPDYEEEYVRERRG-YLTSKAA 552
Cdd:smart00682   80 GFQLTGGVFTRETEVTFAGGEILRIKQTFSGLDEHGYLKVKIEVSGRVPQVAAGAEVTIPDYTEEYTYTGPGvLTTSSTR 159

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392921320    553 FDVIvrdggNVQTYRMSVDQQITFEECPNKEFDRDHSMKLHVKRINVVYNDDEGVVRYGAKNfatrSVGPAVSAPSG 629
Cdd:smart00682  160 EYTV-----DNQTHSYTVDQTITFEECQHRDAFPPTTQQLHVSSVFVDYNDEERVLRFAAHN----SVGPGDESNQC 227
nidG2 cd00255
Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an ...
 400-619 5.57e-85

Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a potential role in the assembly and connection of networks. Nidogen consists of 3 globular domains (G1-G3), G3 is the lamin-binding domain, while G2 binds collagen IV and perlecan. Also found in hemicentin, a protein which functions at various cell-cell and cell-matrix junctions and might assist in refining broad regions of cell contact into oriented, line-shaped junctions. Nidogen G2 consists of an N-terminal EGF-like domain (excluded from this alignment model) and an 11-stranded beta-barrel with a central helix, a topology that exhibits high structural similarity to the green flourescent proteins of Cnidaria.


Pssm-ID: 238158  Cd Length: 224  Bit Score: 277.27  E-value: 5.57e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320  400 GEPQRISGSFEGVIN----RIPIDKTELHTFATSTDGNVHTAVSKIPSDLGHPLRFLYSIGGVMGWLFAdVQSPNVYNGF 475
Cdd:cd00255     1 GIPQRVNGKVSGNINvgqsPVEFGDADLHSYVVTSDGRAYTAISNIPESLGPSLRPLAPIGGTIGWLFA-LEQGGAKNGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320  476 QLTGGLFNRTVALHIE-QNYYVTIKQEFSGRNIHDYFKSHLFVSGTLPDIAPGSEVIFPDYEEEYVRERRGYLTSKAAFD 554
Cdd:cd00255    80 SLTGGEFTRQAEVTFYtGGEKLRITQVARGLDSHGHLLLDTVISGRVPQVPAGATVHIEDYTELYHYTGPGVLTSSSTRE 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392921320  555 VIVRDGGNVQTYRMSVDQQITFEECPNKEFDRDHSMKLHVKRINVVYNDDEGVVRYGAKNFATRS 619
Cdd:cd00255   160 YTVDEGGESQTLSYQWNQTITYEECPHDDEAAPDLQQLLVARIFALYNPEEEILRFAITNSIGPG 224
G2F pfam07474
G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional ...
 400-583 7.72e-66

G2F domain; Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein pfam01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.


Pssm-ID: 462175  Cd Length: 184  Bit Score: 220.54  E-value: 7.72e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320   400 GEPQRISGSFEGVINRIPIDKTELHTFATSTDGNVHTAVSKIPSDLGHPLRFLYSIGGVMGWLFAdVQSPNVYNGFQLTG 479
Cdd:pfam07474    1 GVPQRVNGKVSGTINGVEFGDADLHAYVVTNDGRAYTAISNIPPSLGPLLQLLSSIGGPIGWLFA-LEQGGAKNGFSLTG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320   480 GLFNRTVALHIEQ-NYYVTIKQEFSGRNIHDYFKSHLFVSGTLPDIAPGSEVIFPDYEEEYVRERRGYLTSKAAFDVIVR 558
Cdd:pfam07474   80 GVFNRTAEVTFPPtGERLTITQEFRGLDEDGHLVVDTVISGTVPQVPAGSTVIIEDYTELYQYTGPGELTSSSTRTYTVD 159

                          170       180
                   ....*....|....*....|....*
gi 392921320   559 DGGNVQTYRMSVDQQITFEECPNKE 583
Cdd:pfam07474  160 GEGNTRTISYTVNQTITYQECRHAE 184
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
93-232 6.78e-40

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 145.26  E-value: 6.78e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320     93 VFYVPVT---SGVIDYRVSsDDQGLLTKLTQDVKQVFADAVEFHGLQAVIITWTQIENAEK---DGPASFQLAIVSDGIS 166
Cdd:smart00539    1 PFWADADtegTGKVYYRET-TDHAILDRATESVREGFTDMGGFRAKSVVIVTWENVAAYGSqssDGTNTFQAVLATDGSR 79

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392921320    167 TYAIFRYESLPWSSSM------GYYAQAGFVRSIGKI-QTNVNSGGPDVKELVNLSNNQFGNFFIFRVSGSAI 232
Cdd:smart00539   80 TYAIFLYPSLGWTSDTtaggddGVRARAGFNGGDGTFsYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1262-1456 9.82e-14

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 73.12  E-value: 9.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1262 PVGIDFDCKEEKIVwSDMSGHSIRTSSLNGTEHKSY-----FNKELSSPEGIAVDwSSRNVYYADSMNDEIGVASLNGKF 1336
Cdd:cd05819    57 PAGVAVDSDGNLYV-ADTGNHRIQKFDPDGNFLASFggsgdGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEF 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1337 KKSLVTEG-----LVNPRSVVLDLYGrHLYYSDW--HRenpyIGRVDMDGKNNRVFLNEDVHL-----PNGLTIlpNRRE 1404
Cdd:cd05819   135 LTTFGSGGsgpgqFNGPTGVAVDSDG-NIYVADTgnHR----IQVFDPDGNFLTTFGSTGTGPgqfnyPTGIAV--DSDG 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392921320 1405 LCWV-DAGNHRlscIQY--------NGAGRR-TVFSSLQYPFGLTHDEEQKFYWTDWKDNRI 1456
Cdd:cd05819   208 NIYVaDSGNNR---VQVfdpdgagfGGNGNFlGSDGQFNRPSGLAVDSDGNLYVADTGNNRI 266
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1262-1491 2.09e-13

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 72.35  E-value: 2.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1262 PVGIDFDcKEEKIVWSDMSGHSIRTSSLNGTEHKSY-----FNKELSSPEGIAVDwSSRNVYYADSMNDEIGVASLNGKF 1336
Cdd:cd05819    10 PQGIAVD-SSGNIYVADTGNNRIQVFDPDGNFITSFgsfgsGDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1337 KKSLVTEG-----LVNPRSVVLDLYGrHLYYSDW--HRenpyIGRVDMDGK---------NNRVFLNEdvhlPNGLTIlp 1400
Cdd:cd05819    88 LASFGGSGdgdgeFNGPRGIAVDSSG-NIYVADTgnHR----IQKFDPDGEflttfgsggSGPGQFNG----PTGVAV-- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1401 NRRELCWV-DAGNHRLSCIQYNGAGRRTVFSS------LQYPFGLTHDEEQKFYWTDWKDNRIHsvgVYGEGYRSFqisl 1473
Cdd:cd05819   157 DSDGNIYVaDTGNHRIQVFDPDGNFLTTFGSTgtgpgqFNYPTGIAVDSDGNIYVADSGNNRVQ---VFDPDGAGF---- 229

                         250
                  ....*....|....*...
gi 392921320 1474 GGSGKVFGILAVPKSCVG 1491
Cdd:cd05819   230 GGNGNFLGSDGQFNRPSG 247
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1246-1414 4.90e-12

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 68.09  E-value: 4.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1246 NPDeyGKQLIVIPH-------HIPVGIDfdCKEEKIVWSDMSGHSIRTSSLNGTEHKS-----YFNKELSSPEGIAVDwS 1313
Cdd:cd14963    83 DPD--GKFLKYFPEkkdrvklISPAGLA--IDDGKLYVSDVKKHKVIVFDLEGKLLLEfgkpgSEPGELSYPNGIAVD-E 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1314 SRNVYYADSMNDEIGVASLNGKFKKSL-----VTEGLVNPRSVVLDLYGRhLYYSDWHRENPYIgrVDMDGKNNRVF--- 1385
Cdd:cd14963   158 DGNIYVADSGNGRIQVFDKNGKFIKELngspdGKSGFVNPRGIAVDPDGN-LYVVDNLSHRVYV--FDEQGKELFTFggr 234

                         170       180       190
                  ....*....|....*....|....*....|.
gi 392921320 1386 --LNEDVHLPNGLTILPNRReLCWVDAGNHR 1414
Cdd:cd14963   235 gkDDGQFNLPNGLFIDDDGR-LYVTDRENNR 264
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1262-1456 6.59e-12

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 67.70  E-value: 6.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1262 PVGIDFDckEEKIVWSDMSGHSIRTSSLNGTeHKSYFNK------ELSSPEGIAVDwSSRNVYYADSMNDEIGVASLNGK 1335
Cdd:cd14963    12 PMGVAVS--DGRIYVADTNNHRVQVFDYEGK-FKKSFGGpgtgpgEFKYPYGIAVD-SDGNIYVADLYNGRIQVFDPDGK 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1336 FKKSLVTE--GLVNPRSVVLDLYGRHLYYSDWHRenpyiGRV---DMDGKNNRVFLNE-----DVHLPNGLTILPNRReL 1405
Cdd:cd14963    88 FLKYFPEKkdRVKLISPAGLAIDDGKLYVSDVKK-----HKVivfDLEGKLLLEFGKPgsepgELSYPNGIAVDEDGN-I 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1406 CWVDAGNHRlscIQY-----------NG----------------------------AGRRTVFS---------------- 1430
Cdd:cd14963   162 YVADSGNGR---IQVfdkngkfikelNGspdgksgfvnprgiavdpdgnlyvvdnlSHRVYVFDeqgkelftfggrgkdd 238

                         250       260
                  ....*....|....*....|....*..
gi 392921320 1431 -SLQYPFGLTHDEEQKFYWTDWKDNRI 1456
Cdd:cd14963   239 gQFNLPNGLFIDDDGRLYVTDRENNRV 265
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 712-747 2.30e-11

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 59.53  E-value: 2.30e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 392921320   712 CQRGDHNCDQHAKCTNRPGSFSCQCLQGYQGDGRSC 747
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1262-1456 2.39e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 56.91  E-value: 2.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1262 PVGIDFDcKEEKIVWSDMSGHSIRTSSLNGtEHKSYFNK------ELSSPEGIAVDwSSRNVYYADSMNDEIGVASLNGK 1335
Cdd:cd14956    62 PRGLAVD-KDGWLYVADYWGDRIQVFTLTG-ELQTIGGSsgsgpgQFNAPRGVAVD-ADGNLYVADFGNQRIQKFDPDGS 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1336 FKKSLVTEG-----LVNPRSVVLDLYGrHLYYSDwhRENPYIGRVDMDGKNNRVF-----LNEDVHLPNGLTILPNRRel 1405
Cdd:cd14956   139 FLRQWGGTGiepgsFNYPRGVAVDPDG-TLYVAD--TYNDRIQVFDNDGAFLRKWggrgtGPGQFNYPYGIAIDPDGN-- 213

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1406 CWV-DAGNHRLSciQYNGAGR-RTVFSS-------LQYPFGLTHDEEQKFYWTDWKDNRI 1456
Cdd:cd14956   214 VFVaDFGNNRIQ--KFTADGTfLTSWGSpgtgpgqFKNPWGVVVDADGTVYVADSNNNRV 271
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1338-1381 7.53e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.91  E-value: 7.53e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 392921320   1338 KSLVTEGLVNPRSVVLDLYGRHLYYSDWHRenPYIGRVDMDGKN 1381
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTN 42
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1304-1456 1.24e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 54.98  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1304 SPEGIAVDWSSrNVYYADSMNDEIGVASLNGKFKKSLVTEG-----LVNPRSVVLDLYGRhLYYSDWHreNPYIGRVDMD 1378
Cdd:cd14956    14 DPRGIAVDADD-NVYVADARNGRIQVFDKDGTFLRRFGTTGdgpgqFGRPRGLAVDKDGW-LYVADYW--GDRIQVFTLT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1379 GKNNRVFLNE-----DVHLPNGLTILPNRRelCWV-DAGNHRLSCI--------QYNGAGRRTVfsSLQYPFGLTHDEEQ 1444
Cdd:cd14956    90 GELQTIGGSSgsgpgQFNAPRGVAVDADGN--LYVaDFGNQRIQKFdpdgsflrQWGGTGIEPG--SFNYPRGVAVDPDG 165

                         170
                  ....*....|..
gi 392921320 1445 KFYWTDWKDNRI 1456
Cdd:cd14956   166 TLYVADTYNDRI 177
EGF_CA smart00179
Calcium-binding EGF-like domain;
708-748 1.64e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.64e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 392921320    708 DLDECQRGdHNCDQHAKCTNRPGSFSCQCLQGYQgDGRSCI 748
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1295-1336 3.09e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.98  E-value: 3.09e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 392921320   1295 KSYFNKELSSPEGIAVDWSSRNVYYADSMNDEIGVASLNGKF 1336
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1262-1456 3.78e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 53.48  E-value: 3.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1262 PVGIDFDckEEKIVW-SDMSGHSIRtsSLNGTEHK-SYF--NKELSSPEGIAVDwSSRNVYYADSMNDEIGVASL-NGKF 1336
Cdd:COG4257    61 PHGIAVD--PDGNLWfTDNGNNRIG--RIDPKTGEiTTFalPGGGSNPHGIAFD-PDGNLWFTDQGGNRIGRLDPaTGEV 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1337 KKSLVTEGLVNPRSVVLDLYGRhLYYSDWhrENPYIGRVDMDGKNNRVF-LNEDVHLPNGLTILPNRReLCWVDAGNHRL 1415
Cdd:COG4257   136 TEFPLPTGGAGPYGIAVDPDGN-LWVTDF--GANAIGRIDPDTGTLTEYaLPTPGAGPRGLAVDPDGN-LWVADTGSGRI 211

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 392921320 1416 SciQYN---GAGRRTVFSSLQY-PFGLTHDEEQKFYWTDWKDNRI 1456
Cdd:COG4257   212 G--RFDpktGTVTEYPLPGGGArPYGVAVDGDGRVWFAESGANRI 254
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 155-227 5.10e-07

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 49.21  E-value: 5.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320   155 SFQLAIVSDGISTYAIFRYES--LPW---SSSMGYY------AQAGFvrSIGKIQTNV----NSGGPDVKELVNLSN-NQ 218
Cdd:pfam06119    3 TFQAVLATDGSGSFAIFNYPDggIQWttgKASGGTNglggtpAQAGF--SAGDGDGRYyelpGSGTDSIRNLTETSNvGV 80


                   ....*....
gi 392921320   219 FGnFFIFRV 227
Cdd:pfam06119   81 PG-RWVFRI 88
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1298-1486 1.29e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 51.52  E-value: 1.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1298 FNKELSSPEGIAVDWssRNVYYADSMNDEIGVASLNGKFKKSL-------------------------VTEgLVNPRSVV 1352
Cdd:cd14963     5 FGDPLNKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFggpgtgpgefkypygiavdsdgniyVAD-LYNGRIQV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1353 LDLYGRHLYY---------------SDWHRENPYIGRV--------DMDGKNNRVFLNE-----DVHLPNGLTILPNRRe 1404
Cdd:cd14963    82 FDPDGKFLKYfpekkdrvklispagLAIDDGKLYVSDVkkhkvivfDLEGKLLLEFGKPgsepgELSYPNGIAVDEDGN- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1405 LCWVDAGNHRLSCIQYNGAGRRTV------FSSLQYPFGLTHDEEQKFYWTDWKDNRIHSVGVYGEGYRSFqislGGSGK 1478
Cdd:cd14963   161 IYVADSGNGRIQVFDKNGKFIKELngspdgKSGFVNPRGIAVDPDGNLYVVDNLSHRVYVFDEQGKELFTF----GGRGK 236


                  ....*...
gi 392921320 1479 VFGILAVP 1486
Cdd:cd14963   237 DDGQFNLP 244
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1269-1496 1.32e-06

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 51.82  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1269 CKEEKIVWSDMSGHSIRTSSLNGTEHKSY-FNKELSSpeGIAVDwSSRNVYYADSMNdeiGVASLN---GKFKKsLVTE- 1343
Cdd:COG3386    16 DPDGRLYWVDIPGGRIHRYDPDGGAVEVFaEPSGRPN--GLAFD-PDGRLLVADHGR---GLVRFDpadGEVTV-LADEy 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1344 --GLVNPRSVVLDLYGRhLYYSD--WHRENPYIGRVDMDGKNNRVFlnEDVHLPNGLTILPNRRELCWVDAGNHRLSCIQ 1419
Cdd:COG3386    89 gkPLNRPNDGVVDPDGR-LYFTDmgEYLPTGALYRVDPDGSLRVLA--DGLTFPNGIAFSPDGRTLYVADTGAGRIYRFD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1420 YNGAGR---RTVFSSLQ----YPFGLTHDEEQKFYWTDWKDNRIHsvgVYGEGyrsfqislggsGKVFGILAVPKSCvgP 1492
Cdd:COG3386   166 LDADGTlgnRRVFADLPdgpgGPDGLAVDADGNLWVALWGGGGVV---RFDPD-----------GELLGRIELPERR--P 229


                  ....
gi 392921320 1493 STPC 1496
Cdd:COG3386   230 TNVA 233
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1383-1425 2.07e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.67  E-value: 2.07e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 392921320   1383 RVFLNEDVHLPNGLTILPNRRELCWVDAGNHRLSCIQYNGAGR 1425
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 708-748 2.22e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.22e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 392921320  708 DLDECQRGdHNCDQHAKCTNRPGSFSCQCLQGYQgdGRSCI 748
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYT--GRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
708-739 4.27e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 44.54  E-value: 4.27e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 392921320   708 DLDECQRGDHNCDQHAKCTNRPGSFSCQCLQG 739
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1303-1414 1.14e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.54  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1303 SSPEGIAVDWSSRNVYYADSMNDEIGVASL-NGKFKKSLVTEGlvNPRSVVLDLYGRHLYYSDW--HRENPYIGRVDMDG 1379
Cdd:COG3391   110 GGPRGLAVDPDGGRLYVADSGNGRVSVIDTaTGKVVATIPVGA--GPHGIAVDPDGKRLYVANSgsNTVSVIVSVIDTAT 187

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 392921320 1380 KNNRVFLNEDVHlPNGLTILPNRRELCWVDAGNHR 1414
Cdd:COG3391   188 GKVVATIPVGGG-PVGVAVSPDGRRLYVANRGSNT 221
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1496-1520 2.59e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 2.59e-05
                           10        20
                   ....*....|....*....|....*
gi 392921320  1496 CSEDNGGCQHLCLPGQNGAVCECPD 1520
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1252-1294 4.70e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.82  E-value: 4.70e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 392921320   1252 KQLIVIPHHIPVGIDFDCKEEKIVWSDMSGHSIRTSSLNGTEH 1294
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 1262-1477 8.48e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 46.11  E-value: 8.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1262 PVGIDFDCKEeKIVWSDMSGHSIRTSSLNGTEHKSY-----FNKELSSPEGIAVDwSSRNVYYADSMNDEIGVASLNGKF 1336
Cdd:cd14957    20 PRGIAVDSAG-NIYVADTGNNRIQVFTSSGVYSYSIgsggtGSGQFNSPYGIAVD-SNGNIYVADTDNNRIQVFNSSGVY 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1337 KKSLVTEGLVNPrsvvldlygrhlyYSDWhrenPYIGRVDMDGKnnrVFLnedvhlpngltilpnrrelcwVDAGNHRLS 1416
Cdd:cd14957    98 QYSIGTGGSGDG-------------QFNG----PYGIAVDSNGN---IYV---------------------ADTGNHRIQ 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1417 CIQYNGAGRRTVFSS------LQYPFGLTHDEEQKFYWTDWKDNRIH---SVGVYgegyrsfQISLGGSG 1477
Cdd:cd14957   137 VFTSSGTFSYSIGSGgtgpgqFNGPQGIAVDSDGNIYVADTGNHRIQvftSSGTF-------QYTFGSSG 199
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 705-740 2.49e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 44.30  E-value: 2.49e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 392921320  705 ICQDLDECQRGDHNCDQhaKCTNRPGSFSCQCLQGY 740
Cdd:cd01475   183 ICVVPDLCATLSHVCQQ--VCISTPGSYLCACTEGY 216
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1185-1221 3.97e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 3.97e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 392921320  1185 CLDDRSLCDENADCVPgEAGHYVCNCHYGYHGDGRSC 1221
Cdd:pfam12947    1 CSDNNGGCHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1275-1480 5.04e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 43.85  E-value: 5.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1275 VW-SDMSGHSIRTSSLNGTEHKSYFNKELSSPEGIAVDwSSRNVYYADSMNDEIGVASL-NGKFKKSLVTEGLVNPRSVV 1352
Cdd:COG4257    30 VWfTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVD-PDGNLWFTDNGNNRIGRIDPkTGEITTFALPGGGSNPHGIA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1353 LDLYGRhLYYSDwhRENPYIGRVDMDgknNRVFLNEDVHL----PNGLTILPNRReLCWVDAGNHRLSCIQyNGAGRRTV 1428
Cdd:COG4257   109 FDPDGN-LWFTD--QGGNRIGRLDPA---TGEVTEFPLPTggagPYGIAVDPDGN-LWVTDFGANAIGRID-PDTGTLTE 180

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392921320 1429 F---SSLQYPFGLTHDEEQKFYWTDWKDNRIH-------SVGVY---GEGYRSFQISLGGSGKVF 1480
Cdd:COG4257   181 YalpTPGAGPRGLAVDPDGNLWVADTGSGRIGrfdpktgTVTEYplpGGGARPYGVAVDGDGRVW 245
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 1302-1459 5.63e-04

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 44.06  E-value: 5.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1302 LSSPEGIAVDwSSRNVYYADSMNDEI------GVAS-LNGKFKKSLVTEG------LVNPRSVVLDLYGRhLYYSDwhRE 1368
Cdd:cd14953   131 FNYPTGVAVD-AAGNLYVADTGNHRIrkitpdGVVTtVAGTGGAGYAGDGpataaqFNNPTGVAVDAAGN-LYVAD--RG 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1369 NPYIGRVDMDGK------NNRVFLNED-------VHLPNGLTIlpNRRELCWV-DAGNHRLSCIQYNG-----AGRRTVF 1429
Cdd:cd14953   207 NHRIRKITPDGVvttvagTGTAGFSGDggataaqLNNPTGVAV--DAAGNLYVaDSGNHRIRKITPAGvvttvAGGGAGF 284

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 392921320 1430 S---------SLQYPFGLTHDEEQKFYWTDWKDNRIHSV 1459
Cdd:cd14953   285 SgdggpatsaQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 711-745 5.91e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.61  E-value: 5.91e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 392921320  711 ECQRgDHNCDQHAKCTNRPGSFSCQCLQGYQGDGR 745
Cdd:cd00053     1 ECAA-SNPCSNGGTCVNTPGSYRCVCPPGYTGDRS 34
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1272-1312 7.79e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.68  E-value: 7.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 392921320  1272 EKIVWSDMS-GHSIRTSSLNGTEHKSYFNKELSSPEGIAVDW 1312
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 1278-1422 8.63e-04

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 42.92  E-value: 8.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1278 DMSGHSIRTSSLNGTEhksyfNKELSSPEGIAVDwSSRNVYYADSMNDEIGVASLNGKFKKSLVTEG-----LVNPRSVV 1352
Cdd:cd14954    98 DLNGRFLLKFGERGTK-----NGQFNYPWGVAVD-SEGRIYVSDTRNHRVQVFDSDGQFIRKFGFEGagpgqLDSPRGVA 171

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392921320 1353 LDLYGrHLYYSDW--HRenpyIGRVDMDGKNNRVF-----LNEDVHLPNGLTILPNRRELCwVDAGNHRLSCIQYNG 1422
Cdd:cd14954   172 VNPDG-NIVVSDFnnHR----LQVFDPDGQFLRFFgsegsGNGQFKRPRGVAVDDEGNIIV-ADSGNHRVQVFSPDG 242
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1358-1398 9.77e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.29  E-value: 9.77e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 392921320  1358 RHLYYSDWhRENPYIGRVDMDGKNNRVFLNEDVHLPNGLTI 1398
Cdd:pfam00058    1 GRLYWTDS-SLRASISSADLNGSDRKTLFTDDLQHPNAIAV 40
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 841-870 1.64e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.58  E-value: 1.64e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 392921320   841 CDVNAECmpEPSGGS-ECVCKAGFSGNGVTC 870
Cdd:pfam12947    8 CHPNATC--TNTGGSfTCTCNDGYTGDGVTC 36
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 1301-1384 1.89e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 42.18  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1301 ELSSPEGIAVDwSSRNVYYADSMNDEIGVASLNGKFKKSLVTEG-----LVNPRSVVLDLYGrHLYYSDWHrenpyigrv 1375
Cdd:cd14955   155 QFNSPTGIAVD-SAGNVYVADTGNNRIQKFTSTGTFLTKWGSEGsgdgqFNAPYGIAVDSAG-NVYVADTG--------- 223


                  ....*....
gi 392921320 1376 dmdgkNNRV 1384
Cdd:cd14955   224 -----NNRI 227
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 1299-1385 1.91e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 41.79  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1299 NKELSSPEGIAVDwSSRNVYYADSMNDEIGVASLNGKFKKSLVTEGLVN-----PRSVVLDlygrhlyysdwHRENPYIG 1373
Cdd:cd14955   200 DGQFNAPYGIAVD-SAGNVYVADTGNNRIQKFDSSGTFITKWGSEGSGDgqfnsPSGIAVD-----------SAGNVYVA 267

                          90
                  ....*....|..
gi 392921320 1374 rvdmDGKNNRVF 1385
Cdd:cd14955   268 ----DSGNNRIQ 275
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1148-1179 2.01e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.19  E-value: 2.01e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 392921320  1148 NCSIHAYCaqNPTSGAYQCKCNAGYNGNGHLC 1179
Cdd:pfam12947    7 GCHPNATC--TNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 368-396 3.04e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.81  E-value: 3.04e-03
                           10        20
                   ....*....|....*....|....*....
gi 392921320   368 CHANSVCQDFEGGFCCNCDTGFYGNGKEC 396
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1302-1456 3.61e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.04  E-value: 3.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1302 LSSPEGIAVDwSSRNVYYADSMNDEIgVASLNGKFKKS-LVTEGLVNPRSVVLDLYGrhlyysdwhreNPYIGrvdmDGK 1380
Cdd:cd14952     9 LDGPGGVAVD-AAGNVYVADSGNNRV-LKLAAGSTTQTvLPFTGLYQPQGVAVDAAG-----------TVYVT----DFG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1381 NNRVflnedVHLPNG---LTILP----NRRELCWVDA---------GNHR-LSciQYNGAGRRTV--FSSLQYPFGLTHD 1441
Cdd:cd14952    72 NNRV-----LKLAAGsttQTVLPftglNDPTGVAVDAagnvyvadtGNNRvLK--LAAGSNTQTVlpFTGLSNPDGVAVD 144

                         170
                  ....*....|....*
gi 392921320 1442 EEQKFYWTDWKDNRI 1456
Cdd:cd14952   145 GAGNVYVTDTGNNRV 159
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 1301-1384 4.16e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 41.02  E-value: 4.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1301 ELSSPEGIAVDwSSRNVYYADSMNDEIGVASLNGKFKKSLVTEG-----LVNPRSVVLDLYGrhlyysdwhreNPYIgrV 1375
Cdd:cd14955    14 QFNSPSGIAVD-SAGNVYVADTGNNRIQKFDSTGTFLTKWGSSGsgdgqFYSPTGIAVDSDG-----------NVYV--A 79


                  ....*....
gi 392921320 1376 DMDgkNNRV 1384
Cdd:cd14955    80 DTG--NHRI 86
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1302-1415 4.80e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.65  E-value: 4.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1302 LSSPEGIAVDWSSRnVYYADSMNDEIGVASL-NGKFKKSLVTEG--LVNPRSVVLDLYGRhLYYSDwhRENPYIGRVDMD 1378
Cdd:cd14962    11 LTRPYGVAADGRGR-IYVADTGRGAVFVFDLpNGKVFVIGNAGPnrFVSPIGVAIDANGN-LYVSD--AELGKVFVFDRD 86

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 392921320 1379 GKNNRVF-LNEDVHLPNGLTILPNRRELCWVDAGNHRL 1415
Cdd:cd14962    87 GKFLRAIgAGALFKRPTGIAVDPAGKRLYVVDTLAHKV 124
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1262-1364 6.15e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.26  E-value: 6.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1262 PVGIDFDCKEEKIVWSDMSGHSIRTSSLNGTEHKSyFNK------ELSSPEGIAVDwSSRNVYYADSMNDEIGVASLNGK 1335
Cdd:cd14962   102 PTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFD-IGKrgsgpgEFNLPTDLAVD-RDGNLYVTDTMNFRVQIFDADGK 179

                          90       100       110
                  ....*....|....*....|....*....|....
gi 392921320 1336 FKKSLVTEG-----LVNPRSVVLDLYGrHLYYSD 1364
Cdd:cd14962   180 FLRSFGERGdgpgsFARPKGIAVDSEG-NIYVVD 212
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 1299-1385 6.74e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 40.33  E-value: 6.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921320 1299 NKELSSPEGIAVDwSSRNVYYADSMNDEIGVASLNGKFKKSLVTEGLVN-----PRSVVLDLYGrhlyysdwhreNPYIg 1373
Cdd:cd14957   202 PGQFSDPYGIAVD-SDGNIYVADTGNHRIQVFTSSGAYQYSIGTSGSGNgqfnyPYGIAVDNDG-----------KIYV- 268

                          90
                  ....*....|..
gi 392921320 1374 rvdMDGKNNRVF 1385
Cdd:cd14957   269 ---ADSNNNRIQ 277
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1315-1354 8.20e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.60  E-value: 8.20e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 392921320  1315 RNVYYADSMNDE-IGVASLNGKFKKSLVTEGLVNPRSVVLD 1354
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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