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Conserved domains on  [gi|392921981|ref|NP_001256626|]
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Transmembrane protein 144 [Caenorhabditis elegans]

Protein Classification

L-rhamnose-proton symporter family protein( domain architecture ID 139974)

L-rhamnose-proton symporter family protein such as Escherichia coli RhaT, which is involved in uptake of L-rhamnose across the cytoplasmic membrane with the concomitant transport of protons into the cell

Gene Ontology:  GO:0015293|GO:0015144
PubMed:  1551902
TCDB:  2.A.7.6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhaT super family cl19288
L-rhamnose-proton symport protein (RhaT); This family consists of several bacterial ...
 18-308 5.76e-84

L-rhamnose-proton symport protein (RhaT); This family consists of several bacterial L-rhamnose-proton symport protein (RhaT) sequences.


The actual alignment was detected with superfamily member pfam07857:

Pssm-ID: 302813  Cd Length: 333  Bit Score: 256.21  E-value: 5.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921981   18 GYLTSFMIYAYMEFPGIYGLAMVGGAIWSTTNCFAVQIMSHVGMAMFMLFASSISCLTGWAISRFGLFGVPSAVPMSILL 97
Cdd:pfam07857  40 ILLVGLIVYATLGFPKFEPLAMLGGMLWATGNAFAVPIMNGIGLGVGILIWNTVNCLVGWAVTRFGLFGIPAQVPKSPFL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921981   98 NYNGIILLIVGSSIYPFIK-VNVVGSVASDT----VLPMEKLHQHTQNTEDNVTISYWKKVIAWIGTVIVGLSLGVMTTP 172
Cdd:pfam07857 120 NYIGIVLVVVGGFIFLFIKhVPKENETESDTtpleMEHKKSLEQDLSSDDGLVKKSCTRRIVCILLAIVSGFLYGSTFVP 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921981  173 VTLLMTRHDIYPKSSeiTSPVSFHFSFFTGVMIVSVIIFIAYCFVRKGKPSIPPKIVIPSMLSGVFFSGAMACFFIANEQ 252
Cdd:pfam07857 200 IIYIKDNPPIYPGAP--QDGLDYVFSHYTGIFLTSTVYFFAYSIVKKNNPYVPSELVLPSIGSGILWAIAMTSWFVANQK 277

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 392921981  253 LSPTISYPICMMAPGWITSAWSVFYFREISGRRNLLLLGTAYGFTLFGVLVITASR 308
Cdd:pfam07857 278 LSQVVSYPIISRAPGLIAAAWSVFYFKEIQGKRNYILLGIASAITLIGAIMVALSK 333
 
Name Accession Description Interval E-value
TMEM144 pfam07857
Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug ...
 18-308 5.76e-84

Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug/metabolite transporter (dmt) superfamily. They carry 10xTM domains arranged as 5+5. Although these two sets may originally have arisen by gene-duplication the divergence now is such that the two halves are no longer homologous.


Pssm-ID: 285141  Cd Length: 333  Bit Score: 256.21  E-value: 5.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921981   18 GYLTSFMIYAYMEFPGIYGLAMVGGAIWSTTNCFAVQIMSHVGMAMFMLFASSISCLTGWAISRFGLFGVPSAVPMSILL 97
Cdd:pfam07857  40 ILLVGLIVYATLGFPKFEPLAMLGGMLWATGNAFAVPIMNGIGLGVGILIWNTVNCLVGWAVTRFGLFGIPAQVPKSPFL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921981   98 NYNGIILLIVGSSIYPFIK-VNVVGSVASDT----VLPMEKLHQHTQNTEDNVTISYWKKVIAWIGTVIVGLSLGVMTTP 172
Cdd:pfam07857 120 NYIGIVLVVVGGFIFLFIKhVPKENETESDTtpleMEHKKSLEQDLSSDDGLVKKSCTRRIVCILLAIVSGFLYGSTFVP 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921981  173 VTLLMTRHDIYPKSSeiTSPVSFHFSFFTGVMIVSVIIFIAYCFVRKGKPSIPPKIVIPSMLSGVFFSGAMACFFIANEQ 252
Cdd:pfam07857 200 IIYIKDNPPIYPGAP--QDGLDYVFSHYTGIFLTSTVYFFAYSIVKKNNPYVPSELVLPSIGSGILWAIAMTSWFVANQK 277

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 392921981  253 LSPTISYPICMMAPGWITSAWSVFYFREISGRRNLLLLGTAYGFTLFGVLVITASR 308
Cdd:pfam07857 278 LSQVVSYPIISRAPGLIAAAWSVFYFKEIQGKRNYILLGIASAITLIGAIMVALSK 333
GRP cd23110
glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two ...
 190-306 6.16e-03

glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two functionally characterized members, a glucose uptake permease from Staphylococcus xylosus, and a probable ribose uptake permease from Lactobacillus sakei. Both proteins probably function by H(+) symport. This family also includes several putative and hypothetical membrane proteins that are probably involved in sugar transport across bacterial membranes. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. In Lactococcus lactis, GlcU was identified as the sole non-PTS (phosphoenolpyruvate:phosphotransferase systems) permease involved in the transport of glucose, which is driven by the proton-motive force. A gene from Bacillus subtilis, ycxE, that is homologous to glcU, could substitute for glcU in Escherichia coli glucose growth experiments and restored glucose repression in Staphylococcus xylosus glcU mutants. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438513 [Multi-domain]  Cd Length: 279  Bit Score: 37.82  E-value: 6.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921981 190 TSPVSFHFSFFTGVMIVSVIifiaYCFVRKGKPSIPPKIVIPSMLSGVFFSGAMACFFIANEQLSPTISYPICMMAPgWI 269
Cdd:cd23110  170 VSGLAIFLPQALGMLLGALI----YALFTRKPKALKEKASWRNILTGLLWGIANLAYLLSAQANGVATAFTLSQLNV-VI 244

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 392921981 270 TSAWSVFYFREISGRRNLLllgtaygFTLFGVLVITA 306
Cdd:cd23110  245 STLGGILILHEKKTKRELR-------FTLIGLVLIVA 274
 
Name Accession Description Interval E-value
TMEM144 pfam07857
Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug ...
 18-308 5.76e-84

Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug/metabolite transporter (dmt) superfamily. They carry 10xTM domains arranged as 5+5. Although these two sets may originally have arisen by gene-duplication the divergence now is such that the two halves are no longer homologous.


Pssm-ID: 285141  Cd Length: 333  Bit Score: 256.21  E-value: 5.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921981   18 GYLTSFMIYAYMEFPGIYGLAMVGGAIWSTTNCFAVQIMSHVGMAMFMLFASSISCLTGWAISRFGLFGVPSAVPMSILL 97
Cdd:pfam07857  40 ILLVGLIVYATLGFPKFEPLAMLGGMLWATGNAFAVPIMNGIGLGVGILIWNTVNCLVGWAVTRFGLFGIPAQVPKSPFL 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921981   98 NYNGIILLIVGSSIYPFIK-VNVVGSVASDT----VLPMEKLHQHTQNTEDNVTISYWKKVIAWIGTVIVGLSLGVMTTP 172
Cdd:pfam07857 120 NYIGIVLVVVGGFIFLFIKhVPKENETESDTtpleMEHKKSLEQDLSSDDGLVKKSCTRRIVCILLAIVSGFLYGSTFVP 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921981  173 VTLLMTRHDIYPKSSeiTSPVSFHFSFFTGVMIVSVIIFIAYCFVRKGKPSIPPKIVIPSMLSGVFFSGAMACFFIANEQ 252
Cdd:pfam07857 200 IIYIKDNPPIYPGAP--QDGLDYVFSHYTGIFLTSTVYFFAYSIVKKNNPYVPSELVLPSIGSGILWAIAMTSWFVANQK 277

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 392921981  253 LSPTISYPICMMAPGWITSAWSVFYFREISGRRNLLLLGTAYGFTLFGVLVITASR 308
Cdd:pfam07857 278 LSQVVSYPIISRAPGLIAAAWSVFYFKEIQGKRNYILLGIASAITLIGAIMVALSK 333
GRP cd23110
glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two ...
 190-306 6.16e-03

glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two functionally characterized members, a glucose uptake permease from Staphylococcus xylosus, and a probable ribose uptake permease from Lactobacillus sakei. Both proteins probably function by H(+) symport. This family also includes several putative and hypothetical membrane proteins that are probably involved in sugar transport across bacterial membranes. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. In Lactococcus lactis, GlcU was identified as the sole non-PTS (phosphoenolpyruvate:phosphotransferase systems) permease involved in the transport of glucose, which is driven by the proton-motive force. A gene from Bacillus subtilis, ycxE, that is homologous to glcU, could substitute for glcU in Escherichia coli glucose growth experiments and restored glucose repression in Staphylococcus xylosus glcU mutants. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438513 [Multi-domain]  Cd Length: 279  Bit Score: 37.82  E-value: 6.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392921981 190 TSPVSFHFSFFTGVMIVSVIifiaYCFVRKGKPSIPPKIVIPSMLSGVFFSGAMACFFIANEQLSPTISYPICMMAPgWI 269
Cdd:cd23110  170 VSGLAIFLPQALGMLLGALI----YALFTRKPKALKEKASWRNILTGLLWGIANLAYLLSAQANGVATAFTLSQLNV-VI 244

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 392921981 270 TSAWSVFYFREISGRRNLLllgtaygFTLFGVLVITA 306
Cdd:cd23110  245 STLGGILILHEKKTKRELR-------FTLIGLVLIVA 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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