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Conserved domains on  [gi|400153696|ref|NP_001257810|]
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glucosamine-6-phosphate isomerase 2 isoform 3 [Homo sapiens]

Protein Classification

sugar phosphate isomerase family( domain architecture ID 368)

sugar phosphate isomerase family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SugarP_isomerase super family cl00339
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 1-183 1.16e-116

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


The actual alignment was detected with superfamily member PTZ00285:

Pssm-ID: 469729  Cd Length: 253  Bit Score: 332.11  E-value: 1.16e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   1 MDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPG 80
Cdd:PTZ00285  71 MDEYVGLPRDHPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPG 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696  81 SSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQ 160
Cdd:PTZ00285 151 SSLDSRTRVKSLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQ 230

                        170       180
                 ....*....|....*....|...
gi 400153696 161 QHPRTIFVCDEDATLELRVKTVK 183
Cdd:PTZ00285 231 MHPAAVLCLDEDATLELKVKTTK 253
 
Name Accession Description Interval E-value
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-183 1.16e-116

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 332.11  E-value: 1.16e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   1 MDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPG 80
Cdd:PTZ00285  71 MDEYVGLPRDHPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPG 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696  81 SSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQ 160
Cdd:PTZ00285 151 SSLDSRTRVKSLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQ 230

                        170       180
                 ....*....|....*....|...
gi 400153696 161 QHPRTIFVCDEDATLELRVKTVK 183
Cdd:PTZ00285 231 MHPAAVLCLDEDATLELKVKTTK 253
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 1-177 8.17e-108

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 308.65  E-value: 8.17e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   1 MDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPG 80
Cdd:cd01399   57 LDEYVGLPPDHPQSYHYFMRENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPG 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696  81 SSLVSRTRLKTLAMDTILANAKYFDGDlSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQ 160
Cdd:cd01399  137 SSLDSRTRVVTLDESTRQANARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQ 215

                        170
                 ....*....|....*..
gi 400153696 161 QHPRTIFVCDEDATLEL 177
Cdd:cd01399  216 LHPNVTVILDEAAASEL 232
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-188 7.96e-105

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 302.12  E-value: 7.96e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696    1 MDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPG 80
Cdd:TIGR00502  71 MDEYAGLSEEHPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPG 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   81 SSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQ 160
Cdd:TIGR00502 151 SSLTSRTRIKTLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQ 230

                         170       180
                  ....*....|....*....|....*...
gi 400153696  161 QHPRTIFVCDEDATLELRVKTVKYFKGL 188
Cdd:TIGR00502 231 LHKHAIVVCDENATQELKVKTVEYFNEL 258
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-177 6.18e-88

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 258.94  E-value: 6.18e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   1 MDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPG 80
Cdd:COG0363   71 LDEYVGLPPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPG 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696  81 SSLVSRT-RLKTLAMDTILANAKYFDgDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAF 159
Cdd:COG0363  151 SPFLSETdRVVTLDESTRQANARFFG-SIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASIL 229

                        170
                 ....*....|....*...
gi 400153696 160 QQHPRTIFVCDEDATLEL 177
Cdd:COG0363  230 QGHPNVTWFLDEAAASLL 247
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
2-153 1.31e-16

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 74.97  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696    2 DE-YVglPRNHPES-YHSYMwNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGG------IDLFVGGIGPDGH 73
Cdd:pfam01182  63 DErCV--PPDDPDSnYGMAR-EALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvFDLVLLGMGPDGH 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   74 IA--FnePGSSLVSRTRLKTLAMDtilanakyfdgDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVN 151
Cdd:pfam01182 140 TAslF--PGSPALEETDRLVVAVT-----------DSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPD 206


                  ..
gi 400153696  152 HM 153
Cdd:pfam01182 207 PL 208
 
Name Accession Description Interval E-value
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-183 1.16e-116

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 332.11  E-value: 1.16e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   1 MDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPG 80
Cdd:PTZ00285  71 MDEYVGLPRDHPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPG 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696  81 SSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQ 160
Cdd:PTZ00285 151 SSLDSRTRVKSLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQ 230

                        170       180
                 ....*....|....*....|...
gi 400153696 161 QHPRTIFVCDEDATLELRVKTVK 183
Cdd:PTZ00285 231 MHPAAVLCLDEDATLELKVKTTK 253
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-188 4.78e-113

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 322.93  E-value: 4.78e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   1 MDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPG 80
Cdd:PRK00443  71 LDEYVGLPADHPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPG 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696  81 SSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQ 160
Cdd:PRK00443 151 SSFASRTRIKTLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQ 230

                        170       180
                 ....*....|....*....|....*...
gi 400153696 161 QHPRTIFVCDEDATLELRVKTVKYFKGL 188
Cdd:PRK00443 231 LHPKATLVLDEAAASELKVKTVKYFTEL 258
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 1-177 8.17e-108

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 308.65  E-value: 8.17e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   1 MDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPG 80
Cdd:cd01399   57 LDEYVGLPPDHPQSYHYFMRENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPG 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696  81 SSLVSRTRLKTLAMDTILANAKYFDGDlSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQ 160
Cdd:cd01399  137 SSLDSRTRVVTLDESTRQANARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQ 215

                        170
                 ....*....|....*..
gi 400153696 161 QHPRTIFVCDEDATLEL 177
Cdd:cd01399  216 LHPNVTVILDEAAASEL 232
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-188 7.96e-105

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 302.12  E-value: 7.96e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696    1 MDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPG 80
Cdd:TIGR00502  71 MDEYAGLSEEHPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPG 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   81 SSLVSRTRLKTLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQ 160
Cdd:TIGR00502 151 SSLTSRTRIKTLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQ 230

                         170       180
                  ....*....|....*....|....*...
gi 400153696  161 QHPRTIFVCDEDATLELRVKTVKYFKGL 188
Cdd:TIGR00502 231 LHKHAIVVCDENATQELKVKTVEYFNEL 258
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-177 6.18e-88

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 258.94  E-value: 6.18e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   1 MDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPG 80
Cdd:COG0363   71 LDEYVGLPPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPG 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696  81 SSLVSRT-RLKTLAMDTILANAKYFDgDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAF 159
Cdd:COG0363  151 SPFLSETdRVVTLDESTRQANARFFG-SIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASIL 229

                        170
                 ....*....|....*...
gi 400153696 160 QQHPRTIFVCDEDATLEL 177
Cdd:COG0363  230 QGHPNVTWFLDEAAASLL 247
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 1-181 5.89e-56

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 187.54  E-value: 5.89e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   1 MDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDG--NAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNE 78
Cdd:PRK02122  97 LDEYYPMQPDSLQSYHRFMKENLFDHVDIPPENIHIPDGtiPKEEIDEYCRDYEEKIEAAGGIDFQLLGIGRTGHIGFNE 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696  79 PGSSLVSRTRLKTLAMDTILANAKYFdGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSA 158
Cdd:PRK02122 177 PGSGRNSRTRLVTLDHITRRDAASDF-FGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASY 255

                        170       180
                 ....*....|....*....|....
gi 400153696 159 FQQHPRTIFVCDEDATLEL-RVKT 181
Cdd:PRK02122 256 LQEHPNATFVLDLAAASELtRIKT 279
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 1-166 3.00e-23

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 92.97  E-value: 3.00e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   1 MDEYVGLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADlQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPG 80
Cdd:PRK09762  66 LDEWVDLPLTMPGTCETFLQQHIVQPLGLREDQLISFRSEEIN-ETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPG 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696  81 SSL-----VSRTRLKTLAMDTILANakyfdgdlSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWT 155
Cdd:PRK09762 145 ESLqpachISQLDARTQQHEMLKTA--------GRPVTRGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTAIP 216

                        170
                 ....*....|.
gi 400153696 156 VSAFQQHPRTI 166
Cdd:PRK09762 217 ASFLWLHSNFI 227
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
34-177 2.59e-21

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 87.88  E-value: 2.59e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696  34 AHILDGNAADLQAECDA-FENKIKEAGGIDLFVGGIGPDGHIAFNEPG-SSLVSRTRLKTLA--MDTILANAKyFDGDLS 109
Cdd:PRK12358  91 AGIKEENIHKLTIDNYReHDQKLARDGGLDLVVLGLGADGHFCGNLPGtTHFHDETVEVPIQgeMVDIVAHGE-LGGDFS 169

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 400153696 110 KVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCDEDATLEL 177
Cdd:PRK12358 170 LVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPNLTVILDEAAAAEL 237
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 1-169 3.00e-20

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 83.56  E-value: 3.00e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   1 MDEYVGLPRnHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGpdghiafnepg 80
Cdd:cd00458   56 TDERYVPLD-SDQSNFRQAKLLAFEHDIIPASNVHYVDTSLPIEKACEKYEREILDQVDAIDLAVDGAG----------- 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696  81 sslvsrtrlktlamdtilanakyfdgdlskvptmaltvgvgtvMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQ 160
Cdd:cd00458  124 -------------------------------------------YRAGTVIVLVDGRKKVDYLCQNTEPGVIENGIFADIR 160


                 ....*....
gi 400153696 161 QHPRTIFVC 169
Cdd:cd00458  161 GKEKDIVIV 169
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
2-153 1.31e-16

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 74.97  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696    2 DE-YVglPRNHPES-YHSYMwNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGG------IDLFVGGIGPDGH 73
Cdd:pfam01182  63 DErCV--PPDDPDSnYGMAR-EALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvFDLVLLGMGPDGH 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   74 IA--FnePGSSLVSRTRLKTLAMDtilanakyfdgDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVN 151
Cdd:pfam01182 140 TAslF--PGSPALEETDRLVVAVT-----------DSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPD 206


                  ..
gi 400153696  152 HM 153
Cdd:pfam01182 207 PL 208
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 2-169 1.36e-15

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 72.21  E-value: 1.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   2 DE-YVglPRNHPES-YHSYMwNNFFKHIDIDPNNAHILDGnAADLQAECDAFENKIKEAGG----IDLFVGGIGPDGHIA 75
Cdd:cd01400   59 DErCV--PPDDPDSnYRLAR-EALLSHVAIPAANIHPIPT-ELGPEDAAAAYEKELRALFGgvppFDLVLLGMGPDGHTA 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696  76 --FnePGSSLVSRTRLKT-LAMDtilanakyfdgDLSKVPT--MALTVGVgtVMDAREVMILITGAHKAFALYKAIEEGV 150
Cdd:cd01400  135 slF--PGHPALLEETDRLvVAVT-----------DSPKPPPerITLTLPV--LNNARRVVFLVTGAEKAEALKRALAGPD 199

                        170
                 ....*....|....*....
gi 400153696 151 NHMWTVSAFQQHPRTIFVC 169
Cdd:cd01400  200 PEELPAARVLPRPGEVLWF 218
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 2-177 2.77e-12

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 63.55  E-value: 2.77e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696    2 DE-YVglPRNHPES----YHSYMwnnfFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEA------GGIDLFVGGIGP 70
Cdd:TIGR01198  63 DErYV--PLDHADSntglAREAL----LDRVAIPASNIHPMPTELSDIEEAAELYEQELAAAfqpivfPVFDLLLLGMGP 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   71 DGHIAFNEPGSSLV-SRTRLKTLAMDTIlanakyfdgdlsKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIE-E 148
Cdd:TIGR01198 137 DGHTASLFPHTPALqETERLVTVLTKSP------------KPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAvE 204

                         170       180
                  ....*....|....*....|....*....
gi 400153696  149 GVNHMWTVSAFQQHPRTIFVCDEDATLEL 177
Cdd:TIGR01198 205 AEPYPLPAAGVLHSGKTLWLLDYAAARKL 233
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 2-149 2.01e-03

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 37.92  E-value: 2.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696   2 DEYVgLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDaFE--------------NKIKEAGGIDLFVGG 67
Cdd:PLN02360  80 DERV-VAKNHADSNYKLAKDGLLSKVPVVPSHVYSINDTVTAEEAATD-YEfairqlvktrtigvSDISDCPKFDLILLG 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153696  68 IGPDGHIAfnepgsSLVSRTRLKTLAMDTILanakyFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIE 147
Cdd:PLN02360 158 MGSDGHVA------SLFPNHPALEEKDDWVT-----FITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLAID 226


                 ..
gi 400153696 148 EG 149
Cdd:PLN02360 227 DV 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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