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Conserved domains on  [gi|442616136|ref|NP_001259491|]
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smrter, isoform G [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GPS2_interact super family cl24372
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
708-776 5.72e-13

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


The actual alignment was detected with superfamily member pfam15784:

Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 67.19  E-value: 5.72e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442616136   708 YHPQVEAISPTLPSDSSIEERGRT--SAKEDLLMQIQKVDNEIKSAETTMETLRKKEKSLMEEAALAKEQR 776
Cdd:pfam15784    1 YYPQVEAISPTLPSPEGQDQELSPfrSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPE 71
TPH super family cl38442
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
725-1020 7.40e-05

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


The actual alignment was detected with superfamily member pfam13868:

Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 47.99  E-value: 7.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136   725 IEER--GRTSAKEDLL---MQIQKVDNEIKsAETTMETLRKKEK--SLMEEAALAKEQRAAkelndnnndqepmvelsWR 797
Cdd:pfam13868   82 IEEReqKRQEEYEEKLqerEQMDEIVERIQ-EEDQAEAEEKLEKqrQLREEIDEFNEEQAE-----------------WK 143
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136   798 SQMlAEKIYAANRKTAQAQHSMLQNAAAdesspgsvagrpwlplynqpldVEALAMLIR----QHQSQIRApLLLHIRKL 873
Cdd:pfam13868  144 ELE-KEEEREEDERILEYLKEKAEREEE----------------------REAEREEIEeekeREIARLRA-QQEKAQDE 199
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136   874 KAERWAHNQGLV-EKYtkdQADWQRRcERMEASAKRKAREAKNREFFEKV-FTELRKQRE---DKERFNRVgsrIKSEAD 948
Cdd:pfam13868  200 KAERDELRAKLYqEEQ---ERKERQK-EREEAEKKARQRQELQQAREEQIeLKERRLAEEaerEEEEFERM---LRKQAE 272
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442616136   949 LEEImdglqEQALEDKKmrsyavipplmhdaRQRRCAYHNEnglIEDMVAVHQQRKALNMwtageKETFKEK 1020
Cdd:pfam13868  273 DEEI-----EQEEAEKR--------------RMKRLEHRRE---LEKQIEEREEQRAAER-----EEELEEG 317
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
1009-1048 1.20e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.02  E-value: 1.20e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 442616136  1009 WTAGEKETFKEKYLQHPKNFGAIAASLDRKSPQDCVRYYY 1048
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
2187-2323 2.45e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 2.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136  2187 PPETIIYNVPVAHPQRgIP---PPSQHSVHPAHPSHTQHPAHPQHSSHGQ-------------HTQLQV-PEPEPQTLDL 2249
Cdd:pfam03154  226 APHTLIQQTPTLHPQR-LPsphPPLQPMTQPPPPSQVSPQPLPQPSLHGQmppmphslqtgpsHMQHPVpPQPFPLTPQS 304
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442616136  2250 S---IKKPPRDGHSPHTGAGGSSSSGSGSGGPSSSDRHHGPPPPTMSMKHIVRSggmyrgDTVTVPSLAAPSSYLYP 2323
Cdd:pfam03154  305 SqsqVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPP------PTTPIPQLPNPQSHKHP 375
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
708-776 5.72e-13

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 67.19  E-value: 5.72e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442616136   708 YHPQVEAISPTLPSDSSIEERGRT--SAKEDLLMQIQKVDNEIKSAETTMETLRKKEKSLMEEAALAKEQR 776
Cdd:pfam15784    1 YYPQVEAISPTLPSPEGQDQELSPfrSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPE 71
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
725-1020 7.40e-05

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 47.99  E-value: 7.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136   725 IEER--GRTSAKEDLL---MQIQKVDNEIKsAETTMETLRKKEK--SLMEEAALAKEQRAAkelndnnndqepmvelsWR 797
Cdd:pfam13868   82 IEEReqKRQEEYEEKLqerEQMDEIVERIQ-EEDQAEAEEKLEKqrQLREEIDEFNEEQAE-----------------WK 143
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136   798 SQMlAEKIYAANRKTAQAQHSMLQNAAAdesspgsvagrpwlplynqpldVEALAMLIR----QHQSQIRApLLLHIRKL 873
Cdd:pfam13868  144 ELE-KEEEREEDERILEYLKEKAEREEE----------------------REAEREEIEeekeREIARLRA-QQEKAQDE 199
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136   874 KAERWAHNQGLV-EKYtkdQADWQRRcERMEASAKRKAREAKNREFFEKV-FTELRKQRE---DKERFNRVgsrIKSEAD 948
Cdd:pfam13868  200 KAERDELRAKLYqEEQ---ERKERQK-EREEAEKKARQRQELQQAREEQIeLKERRLAEEaerEEEEFERM---LRKQAE 272
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442616136   949 LEEImdglqEQALEDKKmrsyavipplmhdaRQRRCAYHNEnglIEDMVAVHQQRKALNMwtageKETFKEK 1020
Cdd:pfam13868  273 DEEI-----EQEEAEKR--------------RMKRLEHRRE---LEKQIEEREEQRAAER-----EEELEEG 317
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
726-964 1.14e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.76  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136  726 EERGRTSAKEDLLMQI--QKVDNEIKSAETTMETLRKKEKSLMEEAALAKEQRAAKElndnnnDQEPMVELSWRSQMLAE 803
Cdd:COG4717   170 AELAELQEELEELLEQlsLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELE------EELEQLENELEAAALEE 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136  804 KIYAANR--KTAQAQHSMLQNAAADESSPGSVAGRPWLPLynqPLDVEALAMLIRQH----QSQIRAPLLLHIRKLKAER 877
Cdd:COG4717   244 RLKEARLllLIAAALLALLGLGGSLLSLILTIAGVLFLVL---GLLALLFLLLAREKaslgKEAEELQALPALEELEEEE 320
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136  878 W---AHNQGL--------VEKYTKDQADWQ---RRCERMEASAKRKAREAKNREFFEKV-----------FTELRKQRED 932
Cdd:COG4717   321 LeelLAALGLppdlspeeLLELLDRIEELQellREAEELEEELQLEELEQEIAALLAEAgvedeeelraaLEQAEEYQEL 400
                         250       260       270
                  ....*....|....*....|....*....|...
gi 442616136  933 KERFNRVGSRIKSEA-DLEEIMDGLQEQALEDK 964
Cdd:COG4717   401 KEELEELEEQLEELLgELEELLEALDEEELEEE 433
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
1009-1048 1.20e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.02  E-value: 1.20e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 442616136  1009 WTAGEKETFKEKYLQHPKNFGAIAASLDRKSPQDCVRYYY 1048
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
2187-2323 2.45e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 2.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136  2187 PPETIIYNVPVAHPQRgIP---PPSQHSVHPAHPSHTQHPAHPQHSSHGQ-------------HTQLQV-PEPEPQTLDL 2249
Cdd:pfam03154  226 APHTLIQQTPTLHPQR-LPsphPPLQPMTQPPPPSQVSPQPLPQPSLHGQmppmphslqtgpsHMQHPVpPQPFPLTPQS 304
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442616136  2250 S---IKKPPRDGHSPHTGAGGSSSSGSGSGGPSSSDRHHGPPPPTMSMKHIVRSggmyrgDTVTVPSLAAPSSYLYP 2323
Cdd:pfam03154  305 SqsqVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPP------PTTPIPQLPNPQSHKHP 375
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
1009-1048 3.67e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 37.94  E-value: 3.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 442616136 1009 WTAGEKETFKEKYLQHP-KNFGAIAASLDRKSPQDCVRYYY 1048
Cdd:cd00167     2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWR 42
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
1009-1053 6.96e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 37.20  E-value: 6.96e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 442616136   1009 WTAGEKETFKEKYLQHP-KNFGAIAASLDRKSPQDCVRYYYLSKKT 1053
Cdd:smart00717    4 WTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
708-776 5.72e-13

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 67.19  E-value: 5.72e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442616136   708 YHPQVEAISPTLPSDSSIEERGRT--SAKEDLLMQIQKVDNEIKSAETTMETLRKKEKSLMEEAALAKEQR 776
Cdd:pfam15784    1 YYPQVEAISPTLPSPEGQDQELSPfrSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPE 71
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
725-1020 7.40e-05

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 47.99  E-value: 7.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136   725 IEER--GRTSAKEDLL---MQIQKVDNEIKsAETTMETLRKKEK--SLMEEAALAKEQRAAkelndnnndqepmvelsWR 797
Cdd:pfam13868   82 IEEReqKRQEEYEEKLqerEQMDEIVERIQ-EEDQAEAEEKLEKqrQLREEIDEFNEEQAE-----------------WK 143
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136   798 SQMlAEKIYAANRKTAQAQHSMLQNAAAdesspgsvagrpwlplynqpldVEALAMLIR----QHQSQIRApLLLHIRKL 873
Cdd:pfam13868  144 ELE-KEEEREEDERILEYLKEKAEREEE----------------------REAEREEIEeekeREIARLRA-QQEKAQDE 199
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136   874 KAERWAHNQGLV-EKYtkdQADWQRRcERMEASAKRKAREAKNREFFEKV-FTELRKQRE---DKERFNRVgsrIKSEAD 948
Cdd:pfam13868  200 KAERDELRAKLYqEEQ---ERKERQK-EREEAEKKARQRQELQQAREEQIeLKERRLAEEaerEEEEFERM---LRKQAE 272
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442616136   949 LEEImdglqEQALEDKKmrsyavipplmhdaRQRRCAYHNEnglIEDMVAVHQQRKALNMwtageKETFKEK 1020
Cdd:pfam13868  273 DEEI-----EQEEAEKR--------------RMKRLEHRRE---LEKQIEEREEQRAAER-----EEELEEG 317
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
726-964 1.14e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.76  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136  726 EERGRTSAKEDLLMQI--QKVDNEIKSAETTMETLRKKEKSLMEEAALAKEQRAAKElndnnnDQEPMVELSWRSQMLAE 803
Cdd:COG4717   170 AELAELQEELEELLEQlsLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELE------EELEQLENELEAAALEE 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136  804 KIYAANR--KTAQAQHSMLQNAAADESSPGSVAGRPWLPLynqPLDVEALAMLIRQH----QSQIRAPLLLHIRKLKAER 877
Cdd:COG4717   244 RLKEARLllLIAAALLALLGLGGSLLSLILTIAGVLFLVL---GLLALLFLLLAREKaslgKEAEELQALPALEELEEEE 320
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136  878 W---AHNQGL--------VEKYTKDQADWQ---RRCERMEASAKRKAREAKNREFFEKV-----------FTELRKQRED 932
Cdd:COG4717   321 LeelLAALGLppdlspeeLLELLDRIEELQellREAEELEEELQLEELEQEIAALLAEAgvedeeelraaLEQAEEYQEL 400
                         250       260       270
                  ....*....|....*....|....*....|...
gi 442616136  933 KERFNRVGSRIKSEA-DLEEIMDGLQEQALEDK 964
Cdd:COG4717   401 KEELEELEEQLEELLgELEELLEALDEEELEEE 433
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
1009-1048 1.20e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.02  E-value: 1.20e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 442616136  1009 WTAGEKETFKEKYLQHPKNFGAIAASLDRKSPQDCVRYYY 1048
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
2187-2323 2.45e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 2.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616136  2187 PPETIIYNVPVAHPQRgIP---PPSQHSVHPAHPSHTQHPAHPQHSSHGQ-------------HTQLQV-PEPEPQTLDL 2249
Cdd:pfam03154  226 APHTLIQQTPTLHPQR-LPsphPPLQPMTQPPPPSQVSPQPLPQPSLHGQmppmphslqtgpsHMQHPVpPQPFPLTPQS 304
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442616136  2250 S---IKKPPRDGHSPHTGAGGSSSSGSGSGGPSSSDRHHGPPPPTMSMKHIVRSggmyrgDTVTVPSLAAPSSYLYP 2323
Cdd:pfam03154  305 SqsqVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPP------PTTPIPQLPNPQSHKHP 375
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
1009-1048 3.67e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 37.94  E-value: 3.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 442616136 1009 WTAGEKETFKEKYLQHP-KNFGAIAASLDRKSPQDCVRYYY 1048
Cdd:cd00167     2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWR 42
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
1009-1052 4.17e-03

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 37.59  E-value: 4.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 442616136 1009 WTAGEKETFKEKYLQHPKNFGAIAASLDR-KSPQDCVRYYYLSKK 1052
Cdd:cd11661     2 WSESEAKLFEEGLRKYGKDFHDIRQDFLPwKSVGELVEFYYMWKK 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
1009-1053 6.96e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 37.20  E-value: 6.96e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 442616136   1009 WTAGEKETFKEKYLQHP-KNFGAIAASLDRKSPQDCVRYYYLSKKT 1053
Cdd:smart00717    4 WTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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