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Conserved domains on  [gi|442622524|ref|NP_001260735|]
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uncharacterized protein Dmel_CG3420, isoform B [Drosophila melanogaster]

Protein Classification

CDGSH iron-sulfur domain-containing protein( domain architecture ID 10653773)

CDGSH iron-sulfur domain-containing protein binds a redox-active pH-labile 2Fe-2S cluster; similar to Homo sapiens zinc finger CDGSH domain-containing protein 1

CATH:  3.40.5.90
Gene Ontology:  GO:0051537|GO:0106034|GO:0046872
PubMed:  29556009
SCOP:  3002112

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_CDGSH smart00704
CDGSH-type zinc finger. Function unknown;
95-132 1.71e-13

CDGSH-type zinc finger. Function unknown;


:

Pssm-ID: 197836  Cd Length: 38  Bit Score: 60.05  E-value: 1.71e-13
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 442622524    95 QRPIRFKVEKSGDYWLCNCKQTTHRPFCDGTHKQPHIQ 132
Cdd:smart00704   1 KRPDEVEVEKRKKYALCRCGRSKNFPYCDGSHKKHNEQ 38
ZnF_CDGSH smart00704
CDGSH-type zinc finger. Function unknown;
55-92 8.83e-13

CDGSH-type zinc finger. Function unknown;


:

Pssm-ID: 197836  Cd Length: 38  Bit Score: 58.51  E-value: 8.83e-13
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 442622524    55 KRPFKIHLDKDKTYSWCLCGKSKSQPLCDGMHKNEFLK 92
Cdd:smart00704   1 KRPDEVEVEKRKKYALCRCGRSKNFPYCDGSHKKHNEQ 38
 
Name Accession Description Interval E-value
ZnF_CDGSH smart00704
CDGSH-type zinc finger. Function unknown;
95-132 1.71e-13

CDGSH-type zinc finger. Function unknown;


Pssm-ID: 197836  Cd Length: 38  Bit Score: 60.05  E-value: 1.71e-13
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 442622524    95 QRPIRFKVEKSGDYWLCNCKQTTHRPFCDGTHKQPHIQ 132
Cdd:smart00704   1 KRPDEVEVEKRKKYALCRCGRSKNFPYCDGSHKKHNEQ 38
ZnF_CDGSH smart00704
CDGSH-type zinc finger. Function unknown;
55-92 8.83e-13

CDGSH-type zinc finger. Function unknown;


Pssm-ID: 197836  Cd Length: 38  Bit Score: 58.51  E-value: 8.83e-13
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 442622524    55 KRPFKIHLDKDKTYSWCLCGKSKSQPLCDGMHKNEFLK 92
Cdd:smart00704   1 KRPDEVEVEKRKKYALCRCGRSKNFPYCDGSHKKHNEQ 38
COG3369 COG3369
Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];
51-87 8.09e-10

Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];


Pssm-ID: 442596  Cd Length: 68  Bit Score: 51.63  E-value: 8.09e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 442622524  51 TIFDKRPFKIHLD------------KDKTYSWCLCGKSKSQPLCDGMHK 87
Cdd:COG3369    7 TVAKNGPLLVEGDveivdadgneyeEGKRYALCRCGLSKNKPFCDGSHK 55
COG3369 COG3369
Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];
102-128 2.09e-07

Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];


Pssm-ID: 442596  Cd Length: 68  Bit Score: 45.08  E-value: 2.09e-07
                         10        20
                 ....*....|....*....|....*..
gi 442622524 102 VEKSGDYWLCNCKQTTHRPFCDGTHKQ 128
Cdd:COG3369   30 YEEGKRYALCRCGLSKNKPFCDGSHKG 56
zf-CDGSH pfam09360
Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than ...
 63-87 8.37e-06

Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.


Pssm-ID: 462769  Cd Length: 41  Bit Score: 40.36  E-value: 8.37e-06
                          10        20
                  ....*....|....*....|....*
gi 442622524   63 DKDKTYSWCLCGKSKSQPLCDGMHK 87
Cdd:pfam09360  17 EGRFVVALCRCGRSKNKPFCDGSHK 41
zf-CDGSH pfam09360
Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than ...
 108-127 1.57e-04

Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.


Pssm-ID: 462769  Cd Length: 41  Bit Score: 36.89  E-value: 1.57e-04
                          10        20
                  ....*....|....*....|
gi 442622524  108 YWLCNCKQTTHRPFCDGTHK 127
Cdd:pfam09360  22 VALCRCGRSKNKPFCDGSHK 41
 
Name Accession Description Interval E-value
ZnF_CDGSH smart00704
CDGSH-type zinc finger. Function unknown;
95-132 1.71e-13

CDGSH-type zinc finger. Function unknown;


Pssm-ID: 197836  Cd Length: 38  Bit Score: 60.05  E-value: 1.71e-13
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 442622524    95 QRPIRFKVEKSGDYWLCNCKQTTHRPFCDGTHKQPHIQ 132
Cdd:smart00704   1 KRPDEVEVEKRKKYALCRCGRSKNFPYCDGSHKKHNEQ 38
ZnF_CDGSH smart00704
CDGSH-type zinc finger. Function unknown;
55-92 8.83e-13

CDGSH-type zinc finger. Function unknown;


Pssm-ID: 197836  Cd Length: 38  Bit Score: 58.51  E-value: 8.83e-13
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 442622524    55 KRPFKIHLDKDKTYSWCLCGKSKSQPLCDGMHKNEFLK 92
Cdd:smart00704   1 KRPDEVEVEKRKKYALCRCGRSKNFPYCDGSHKKHNEQ 38
COG3369 COG3369
Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];
51-87 8.09e-10

Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];


Pssm-ID: 442596  Cd Length: 68  Bit Score: 51.63  E-value: 8.09e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 442622524  51 TIFDKRPFKIHLD------------KDKTYSWCLCGKSKSQPLCDGMHK 87
Cdd:COG3369    7 TVAKNGPLLVEGDveivdadgneyeEGKRYALCRCGLSKNKPFCDGSHK 55
COG3369 COG3369
Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];
102-128 2.09e-07

Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];


Pssm-ID: 442596  Cd Length: 68  Bit Score: 45.08  E-value: 2.09e-07
                         10        20
                 ....*....|....*....|....*..
gi 442622524 102 VEKSGDYWLCNCKQTTHRPFCDGTHKQ 128
Cdd:COG3369   30 YEEGKRYALCRCGLSKNKPFCDGSHKG 56
zf-CDGSH pfam09360
Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than ...
 63-87 8.37e-06

Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.


Pssm-ID: 462769  Cd Length: 41  Bit Score: 40.36  E-value: 8.37e-06
                          10        20
                  ....*....|....*....|....*
gi 442622524   63 DKDKTYSWCLCGKSKSQPLCDGMHK 87
Cdd:pfam09360  17 EGRFVVALCRCGRSKNKPFCDGSHK 41
zf-CDGSH pfam09360
Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than ...
 108-127 1.57e-04

Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.


Pssm-ID: 462769  Cd Length: 41  Bit Score: 36.89  E-value: 1.57e-04
                          10        20
                  ....*....|....*....|
gi 442622524  108 YWLCNCKQTTHRPFCDGTHK 127
Cdd:pfam09360  22 VALCRCGRSKNKPFCDGSHK 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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