|
Name |
Accession |
Description |
Interval |
E-value |
| UCH |
pfam00443 |
Ubiquitin carboxyl-terminal hydrolase; |
1110-1479 |
3.05e-45 |
|
Ubiquitin carboxyl-terminal hydrolase;
Pssm-ID: 425685 [Multi-domain] Cd Length: 310 Bit Score: 166.46 E-value: 3.05e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1110 RGLTNRSNYCYINSILQALLGCSPFYNLLRSIPkqaavlSEVKTPTVNAMMSFMTNFSSLpsglrlrLNNLNKGSQSKgk 1189
Cdd:pfam00443 1 TGLVNLGNTCYMNSVLQSLFSIPPFRDYLLRIS------PLSEDSRYNKDINLLCALRDL-------FKALQKNSKSS-- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1190 ddfvgsdlqcdmAFEPTEIYKLWNDSREEHVEGRQEDAEEFLGYVLNKLNDEMleviklidkptpqqngqepaepedggd 1269
Cdd:pfam00443 66 ------------SVSPKMFKKSLGKLNPDFSGYKQQDAQEFLLFLLDGLHEDL--------------------------- 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1270 vwqmicnnrNKGSVTRQTDfgrtPVSDIFRGELRSRLQ-REGEHSTDVIQPFFTLQLNIEKAASVKEALEI---LVGRDQ 1345
Cdd:pfam00443 107 ---------NGNHSTENES----LITDLFRGQLKSRLKcLSCGEVSETFEPFSDLSLPIPGDSAELKTASLqicFLQFSK 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1346 LEGVTG------SKTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSDGCTKILKKVDFPVELKIDAKILGSKKTSQKQ-RA 1418
Cdd:pfam00443 174 LEELDDeekyycDKCGCKQDAIKQLKISRLPPVLIIHLKRFSYNRSTWEKLNTEVEFPLELDLSRYLAEELKPKTNNlQD 253
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442629288 1419 YRLFAVVYHDGkEASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHTprvPYLLYY 1479
Cdd:pfam00443 254 YRLVAVVVHSG-SLSSGHYIAYIKAYENNRWYKFDDEKVTEVDEETAVLSSS---AYILFY 310
|
|
| Peptidase_C19 |
cd02257 |
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ... |
1223-1480 |
3.19e-40 |
|
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239072 [Multi-domain] Cd Length: 255 Bit Score: 149.94 E-value: 3.19e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1223 RQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQNgqepaepedggdvwqmicnnrnkgsvtrqtdfgrtPVSDIFRGEL 1302
Cdd:cd02257 21 EQQDAHEFLLFLLDKLHEELKKSSKRTSDSSSLKS-----------------------------------LIHDLFGGKL 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1303 RSRLQ-REGEHSTDVIQPFFTLQLNI----EKAASVKEALEILVGRDQLEGV--TGSKTKQEVVAWQQMTLEKLPVVLIL 1375
Cdd:cd02257 66 ESTIVcLECGHESVSTEPELFLSLPLpvkgLPQVSLEDCLEKFFKEEILEGDncYKCEKKKKQEATKRLKIKKLPPVLII 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1376 HLKYFDYRSDGCT-KILKKVDFPVELKIDAKILGSKK---TSQKQRAYRLFAVVYHDGKEASKGHYITDVFHTGYSSWLR 1451
Cdd:cd02257 146 HLKRFSFNEDGTKeKLNTKVSFPLELDLSPYLSEGEKdsdSDNGSYKYELVAVVVHSGTSADSGHYVAYVKDPSDGKWYK 225
|
250 260 270
....*....|....*....|....*....|
gi 442629288 1452 YDDSSVKPVSEKHVLQPHTPR-VPYLLYYR 1480
Cdd:cd02257 226 FNDDKVTEVSEEEVLEFGSLSsSAYILFYE 255
|
|
| Peptidase_C19E |
cd02661 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1109-1479 |
2.51e-38 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239126 [Multi-domain] Cd Length: 304 Bit Score: 145.88 E-value: 2.51e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1109 PRGLTNRSNYCYINSILQALLGCSPFYNLLRSipKQAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRLRlnnlnkgsqskg 1188
Cdd:cd02661 1 GAGLQNLGNTCFLNSVLQCLTHTPPLANYLLS--REHSKDCCNEGFCMMCALEAHVERALASSGPGSA------------ 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1189 kddfvgsdlqcdMAFEPTEIYKLWNDSREehveGRQEDAEEFLGYVLNKlndemleviklidkptpqqngqepaepedgg 1268
Cdd:cd02661 67 ------------PRIFSSNLKQISKHFRI----GRQEDAHEFLRYLLDA------------------------------- 99
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1269 dvWQMICNNRNKGSV-TRQTDFGRTPVSDIFRGELRSRLQREG-EHSTDVIQPFFTLQLNIEKAASVKEALEILVGRDQL 1346
Cdd:cd02661 100 --MQKACLDRFKKLKaVDPSSQETTLVQQIFGGYLRSQVKCLNcKHVSNTYDPFLDLSLDIKGADSLEDALEQFTKPEQL 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1347 EG---VTGSKTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSDGctKILKKVDFPveLKIDAKILGSKKTSQKQRaYRLFA 1423
Cdd:cd02661 178 DGenkYKCERCKKKVKASKQLTIHRAPNVLTIHLKRFSNFRGG--KINKQISFP--ETLDLSPYMSQPNDGPLK-YKLYA 252
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 442629288 1424 VVYHDGKEASKGHYITDVfHTGYSSWLRYDDSSVKPVSEKHVL-QPhtprvPYLLYY 1479
Cdd:cd02661 253 VLVHSGFSPHSGHYYCYV-KSSNGKWYNMDDSKVSPVSIETVLsQK-----AYILFY 303
|
|
| Peptidase_C19R |
cd02674 |
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1294-1480 |
1.16e-28 |
|
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239139 [Multi-domain] Cd Length: 230 Bit Score: 115.85 E-value: 1.16e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1294 VSDIFRGELRSRLQ-REGEHSTDVIQPFFTLQLNI------EKAASVKEALEILVGRDQLEG---VTGSKTKQEVVAWQQ 1363
Cdd:cd02674 40 IVDLFQGQLKSRLTcLTCGKTSTTFEPFTYLSLPIpsgsgdAPKVTLEDCLRLFTKEETLDGdnaWKCPKCKKKRKATKK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1364 MTLEKLPVVLILHLKYFDYRSDGCTKILKKVDFPVE-LKIDAKILGSKKTSQKQraYRLFAVVYHDGKeASKGHYITDVF 1442
Cdd:cd02674 120 LTISRLPKVLIIHLKRFSFSRGSTRKLTTPVTFPLNdLDLTPYVDTRSFTGPFK--YDLYAVVNHYGS-LNGGHYTAYCK 196
|
170 180 190
....*....|....*....|....*....|....*...
gi 442629288 1443 HTGYSSWLRYDDSSVKPVSEKHVLQPHtprvPYLLYYR 1480
Cdd:cd02674 197 NNETNDWYKFDDSRVTKVSESSVVSSS----AYILFYE 230
|
|
| Peptidase_C19G |
cd02663 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1111-1479 |
7.09e-26 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239128 [Multi-domain] Cd Length: 300 Bit Score: 109.71 E-value: 7.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1111 GLTNRSNYCYINSILQALLgcspFYNLLRSIPKQAAVLSEVKTPT-VNAMMSFMTnfsslpsglRLRLNNlnkgsqskgk 1189
Cdd:cd02663 1 GLENFGNTCYCNSVLQALY----FENLLTCLKDLFESISEQKKRTgVISPKKFIT---------RLKREN---------- 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1190 ddfvgsdlqcdmafepteiyKLWNDSReehvegrQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPQQNGQEPaepedggd 1269
Cdd:cd02663 58 --------------------ELFDNYM-------HQDAHEFLNFLLNEIAEILDAERKAEKANRKLNNNNNA-------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1270 vwqmicnnrnkgsvtrqtDFGRTPVSDIFRGELRSR---LQREGEHSTDviQPFFTLQLNIEKAASVKEAL------EIL 1340
Cdd:cd02663 103 ------------------EPQPTWVHEIFQGILTNEtrcLTCETVSSRD--ETFLDLSIDVEQNTSITSCLrqfsatETL 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1341 VGRDQLEGVTGSkTKQEvvAWQQMTLEKLPVVLILHLKYFDY--RSDGCTKILKKVDFPVELkidaKILGSKKTSQKQ-R 1417
Cdd:cd02663 163 CGRNKFYCDECC-SLQE--AEKRMKIKKLPKILALHLKRFKYdeQLNRYIKLFYRVVFPLEL----RLFNTTDDAENPdR 235
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442629288 1418 AYRLFAVVYHDGKEASKGHYITDVFHTGYssWLRYDDSSVKPVSEKHVL----QPHTPRVPYLLYY 1479
Cdd:cd02663 236 LYELVAVVVHIGGGPNHGHYVSIVKSHGG--WLLFDDETVEKIDENAVEeffgDSPNQATAYVLFY 299
|
|
| Peptidase_C19D |
cd02660 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1110-1479 |
5.55e-25 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239125 [Multi-domain] Cd Length: 328 Bit Score: 107.84 E-value: 5.55e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1110 RGLTNRSNYCYINSILQALLGCSPFYNLlrsipkqaavlsevktptvnammsFMTNFSSLPSGLRLRLNNLNKgSQSKGK 1189
Cdd:cd02660 1 RGLINLGATCFMNVILQALLHNPLLRNY------------------------FLSDRHSCTCLSCSPNSCLSC-AMDEIF 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1190 DDFVGSDLQcdMAFEPTEI-YKLWNDSReeHVEG-RQEDAEEFLGYVLNKLNDEMLEVIKLIDKPTPqqngqepaepedg 1267
Cdd:cd02660 56 QEFYYSGDR--SPYGPINLlYLSWKHSR--NLAGySQQDAHEFFQFLLDQLHTHYGGDKNEANDESH------------- 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1268 gdvwqmiCNnrnkgsvtrqtdfgrTPVSDIFRGELRSRLQREGEHSTDV-IQPFFTLQLNIEKAASVKEALEILVGRDQ- 1345
Cdd:cd02660 119 -------CN---------------CIIHQTFSGSLQSSVTCQRCGGVSTtVDPFLDLSLDIPNKSTPSWALGESGVSGTp 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1346 -LEGVTGSKTKQE---------------VVAWQQMTLEKLPVVLILHLKYFDYRSDG-CTKILKKVDFPVELKI----DA 1404
Cdd:cd02660 177 tLSDCLDRFTRPEklgdfaykcsgcgstQEATKQLSIKKLPPVLCFQLKRFEHSLNKtSRKIDTYVQFPLELNMtpytSS 256
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442629288 1405 KILGSKKTSQKQRA--YRLFAVVYHDGKeASKGHYITDVFHtGYSSWLRYDDSSVKPVSEKHVLQPHTprvpYLLYY 1479
Cdd:cd02660 257 SIGDTQDSNSLDPDytYDLFAVVVHKGT-LDTGHYTAYCRQ-GDGQWFKFDDAMITRVSEEEVLKSQA----YLLFY 327
|
|
| peptidase_C19C |
cd02659 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1111-1484 |
3.66e-20 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239124 [Multi-domain] Cd Length: 334 Bit Score: 93.48 E-value: 3.66e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1111 GLTNRSNYCYINSILQALLGCSPFYNLLRSIPkqaavlsevktPTVNAmmsfmTNFSSLPSGL-RLRLNNLNKGSQSKGK 1189
Cdd:cd02659 4 GLKNQGATCYMNSLLQQLYMTPEFRNAVYSIP-----------PTEDD-----DDNKSVPLALqRLFLFLQLSESPVKTT 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1190 DDFVgsdlqcdmafeptEIYKLWNDSREEhveGRQEDAEEFLGYVLNKLNDEMleviklidKPTPQQNgqepaepedggd 1269
Cdd:cd02659 68 ELTD-------------KTRSFGWDSLNT---FEQHDVQEFFRVLFDKLEEKL--------KGTGQEG------------ 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1270 vwqmicnnrnkgsvtrqtdfgrtPVSDIFRGELRSRLQ-REGEHSTDVIQPFFTLQLNIEKAASVKEALEILVGRDQLEG 1348
Cdd:cd02659 112 -----------------------LIKNLFGGKLVNYIIcKECPHESEREEYFLDLQVAVKGKKNLEESLDAYVQGETLEG 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1349 ---VTGSKTKQEVVAWQQMTLEKLPVVLILHLKYF--DYRSDGCTKILKKVDFPVELKID-------AKILGSKKTSQKQ 1416
Cdd:cd02659 169 dnkYFCEKCGKKVDAEKGVCFKKLPPVLTLQLKRFefDFETMMRIKINDRFEFPLELDMEpytekglAKKEGDSEKKDSE 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1417 RA-YRLFAVVYHDGkEASKGHY---ITDVFHtgySSWLRYDDSSVKPVSEKHVL---------QPHTPRVP--------- 1474
Cdd:cd02659 249 SYiYELHGVLVHSG-DAHGGHYysyIKDRDD---GKWYKFNDDVVTPFDPNDAEeecfggeetQKTYDSGPrafkrttna 324
|
410
....*....|
gi 442629288 1475 YLLYYRRSDT 1484
Cdd:cd02659 325 YMLFYERKSP 334
|
|
| Peptidase_C19K |
cd02667 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1291-1480 |
1.01e-15 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239132 [Multi-domain] Cd Length: 279 Bit Score: 79.35 E-value: 1.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1291 RTPVSDIFRGELRSRLQRE--GEHSTDViQPFFTLQL----NIEKAASVKEALEILVGRDQLEGVTGSKTKQEVVAWQQM 1364
Cdd:cd02667 66 RTFIDSIFGGELTSTIMCEscGTVSLVY-EPFLDLSLprsdEIKSECSIESCLKQFTEVEILEGNNKFACENCTKAKKQY 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1365 TLEKLPVVLILHLKYF-DYRSDGCTKILKKVDFPVELKIdAKILGSKKTS---QKQRAYRLFAVVYHDGKEASkGHYI-- 1438
Cdd:cd02667 145 LISKLPPVLVIHLKRFqQPRSANLRKVSRHVSFPEILDL-APFCDPKCNSsedKSSVLYRLYGVVEHSGTMRS-GHYVay 222
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442629288 1439 -------------------TDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHtprvPYLLYYR 1480
Cdd:cd02667 223 vkvrppqqrlsdltkskpaADEAGPGSGQWYYISDSDVREVSLEEVLKSE----AYLLFYE 279
|
|
| Peptidase_C19O |
cd02671 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1111-1480 |
3.17e-15 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239136 [Multi-domain] Cd Length: 332 Bit Score: 78.78 E-value: 3.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1111 GLTNRSNYCYINSILQALLGCSPFYNLLRSipkqaavLSEVKTPTVNAMMSFMTNFSSLPSGLRlrlnnlnkgSQSKGKd 1190
Cdd:cd02671 26 GLNNLGNTCYLNSVLQVLYFCPGFKHGLKH-------LVSLISSVEQLQSSFLLNPEKYNDELA---------NQAPRR- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1191 dfvgsdlqcdmafepteiykLWNDSREEH--VEG-RQEDAEEFLGYVLNKLND---EMLEviklidkptpqqngqepaep 1264
Cdd:cd02671 89 --------------------LLNALREVNpmYEGyLQHDAQEVLQCILGNIQElveKDFQ-------------------- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1265 edGGDVWQMICNNRNkgSVTRQtdfgRTPVSDIFRGELRSRLQREGEHSTDVIQPFF---TLQLNIEKAASVkealEILV 1341
Cdd:cd02671 129 --GQLVLRTRCLECE--TFTER----REDFQDISVPVQESELSKSEESSEISPDPKTemkTLKWAISQFASV----ERIV 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1342 GRDQL--EGVTGSKTkqevvAWQQMTLEKLPVVLILHLKYFDYRS--DGCTKILKKVDFPVELKIDAKILGsKKTSQKQR 1417
Cdd:cd02671 197 GEDKYfcENCHHYTE-----AERSLLFDKLPEVITIHLKCFAANGseFDCYGGLSKVNTPLLTPLKLSLEE-WSTKPKND 270
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442629288 1418 AYRLFAVVYHDGKEASKGHYITdvfhtgYSSWLRYDDSSVKPVSEKHVLQPHTPR-----VPYLLYYR 1480
Cdd:cd02671 271 VYRLFAVVMHSGATISSGHYTA------YVRWLLFDDSEVKVTEEKDFLEALSPNtsstsTPYLLFYK 332
|
|
| Peptidase_C19A |
cd02657 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1111-1466 |
4.56e-15 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239122 [Multi-domain] Cd Length: 305 Bit Score: 77.76 E-value: 4.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1111 GLTNRSNYCYINSILQALlgcspfynllRSIPKQAAVLSEVKtptvNAMMSFMTNFSSLPSGLRLRLNNLNKGSQskgkd 1190
Cdd:cd02657 1 GLTNLGNTCYLNSTLQCL----------RSVPELRDALKNYN----PARRGANQSSDNLTNALRDLFDTMDKKQE----- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1191 dfvgsdlqcdmAFEPTEiykLWNDSR-------EEHVEG--RQEDAEEFLGYVLNKLNDEMleviklidkptpqqngqep 1261
Cdd:cd02657 62 -----------PVPPIE---FLQLLRmafpqfaEKQNQGgyAQQDAEECWSQLLSVLSQKL------------------- 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1262 aepeDGGDvwqmicnnrNKGSVtrqtdfgrtpVSDIFRGELRSRLQREG--EHSTDVIQPFFTLQLNIEKAASVKEALEI 1339
Cdd:cd02657 109 ----PGAG---------SKGSF----------IDQLFGIELETKMKCTEspDEEEVSTESEYKLQCHISITTEVNYLQDG 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1340 LVGRDQLEGVTGSKTKQEVVAWQQMTL-EKLPVVLILHLKYFDYRSDGCT--KILKKVDFPVELKIDAKILGSKKtsqkq 1416
Cdd:cd02657 166 LKKGLEEEIEKHSPTLGRDAIYTKTSRiSRLPKYLTVQFVRFFWKRDIQKkaKILRKVKFPFELDLYELCTPSGY----- 240
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 442629288 1417 raYRLFAVVYHDGKEASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVL 1466
Cdd:cd02657 241 --YELVAVITHQGRSADSGHYVAWVRRKNDGKWIKFDDDKVSEVTEEDIL 288
|
|
| Peptidase_C19B |
cd02658 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1111-1457 |
8.40e-14 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239123 [Multi-domain] Cd Length: 311 Bit Score: 74.28 E-value: 8.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1111 GLTNRSNYCYINSILQALLGCSPF---YNLLRSIPKQAavlseVKTPTVNammsFMTNFSSLPSGLRLrlnnlnkGSQSK 1187
Cdd:cd02658 1 GLRNLGNSCYLNSVLQVLFSIPSFqwrYDDLENKFPSD-----VVDPAND----LNCQLIKLADGLLS-------GRYSK 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1188 -GKDDFVGSDLQCDMAfePTEIYKLWNDSREEHVEGRQEDAEEFLGYVLNKLNDEmlEVIKLIDKPTPQ---QNGQEpae 1263
Cdd:cd02658 65 pASLKSENDPYQVGIK--PSMFKALIGKGHPEFSTMRQQDALEFLLHLIDKLDRE--SFKNLGLNPNDLfkfMIEDR--- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1264 pedggdvwqMICNNRNKGSVTRQtdfgrtpVSDIFRGELRSRLQREGEHSTDVIQPfftlqlniekaASVKEALEILVGR 1343
Cdd:cd02658 138 ---------LECLSCKKVKYTSE-------LSEILSLPVPKDEATEKEEGELVYEP-----------VPLEDCLKAYFAP 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1344 DQLEGvTGSKTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSDGctkILKKVDfpVELKIDaKILGSKKtsqkqraYRLFA 1423
Cdd:cd02658 191 ETIED-FCSTCKEKTTATKTTGFKTFPDYLVINMKRFQLLENW---VPKKLD--VPIDVP-EELGPGK-------YELIA 256
|
330 340 350
....*....|....*....|....*....|....*....
gi 442629288 1424 VVYHDGKEASKGHYitdVFH-----TGYSSWLRYDDSSV 1457
Cdd:cd02658 257 FISHKGTSVHSGHY---VAHikkeiDGEGKWVLFNDEKV 292
|
|
| COG5077 |
COG5077 |
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ... |
1111-1482 |
3.43e-11 |
|
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227409 [Multi-domain] Cd Length: 1089 Bit Score: 68.36 E-value: 3.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1111 GLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQaavlsevkTPTVNammsfmtnfSSLPSGLRLRLNNLNKGSQSKGKD 1190
Cdd:COG5077 195 GLRNQGATCYMNSLLQSLFFIAKFRKDVYGIPTD--------HPRGR---------DSVALALQRLFYNLQTGEEPVDTT 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1191 DFVGSDLqcdmafepteiyklWNDsrEEHVegRQEDAEEFLGYVLNKLNDEMleviklidKPTPQQNGqepaepedggdv 1270
Cdd:COG5077 258 ELTRSFG--------------WDS--DDSF--MQHDIQEFNRVLQDNLEKSM--------RGTVVENA------------ 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1271 wqmicnnrnkgsvtrqtdfgrtpVSDIFRGELRSR---LQREGEHSTdvIQPFFTLQLNIEKAASVKEALEILVGRDQLE 1347
Cdd:COG5077 300 -----------------------LNGIFVGKMKSYikcVNVNYESAR--VEDFWDIQLNVKGMKNLQESFRRYIQVETLD 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1348 GVT--GSKTKQEVVAWQQMTLEKLPVVLILHLKYFDY--RSDGCTKILKKVDFPVElkIDAKILGSKKTSQKQRA---YR 1420
Cdd:COG5077 355 GDNryNAEKHGLQDAKKGVIFESLPPVLHLQLKRFEYdfERDMMVKINDRYEFPLE--IDLLPFLDRDADKSENSdavYV 432
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1421 LFAVVYHDGkEASKGHYITDVFHTGYSSWLRYDDSSVKPVSEKHVLQP-----HTPRVP--------------YLLYYRR 1481
Cdd:COG5077 433 LYGVLVHSG-DLHEGHYYALLKPEKDGRWYKFDDTRVTRATEKEVLEEnfggdHPYKDKirdhsgikrfmsayMLVYLRK 511
|
.
gi 442629288 1482 S 1482
Cdd:COG5077 512 S 512
|
|
| Peptidase_C19I |
cd02665 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1293-1461 |
1.03e-10 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239130 [Multi-domain] Cd Length: 228 Bit Score: 63.35 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1293 PVSDIFRGELRSRLQREGEHSTDvIQPFFTLQLNIEKAASVKEALEILVGRDQLEGVtgsKTKQEVVAWQQMTLEKLPVV 1372
Cdd:cd02665 56 PMVQLFYGTFLTEGVLEGKPFCN-CETFGQYPLQVNGYGNLHECLEAAMFEGEVELL---PSDHSVKSGQERWFTELPPV 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1373 LILHLKYFDYRSDGCTKILKKVDFPVELKidakilgskktsqkQRAYRLFAVVYHDGkEASKGHYITDVFHTGYSSWLRY 1452
Cdd:cd02665 132 LTFELSRFEFNQGRPEKIHDKLEFPQIIQ--------------QVPYELHAVLVHEG-QANAGHYWAYIYKQSRQEWEKY 196
|
....*....
gi 442629288 1453 DDSSVKPVS 1461
Cdd:cd02665 197 NDISVTESS 205
|
|
| UBP12 |
COG5560 |
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; |
1360-1481 |
4.93e-10 |
|
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227847 [Multi-domain] Cd Length: 823 Bit Score: 64.52 E-value: 4.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1360 AWQQMTLEKLPVVLILHLKYFDYRSDGCTKILKKVDFPVElKIDAK-ILGSKKTSqkQRAYRLFAVVYHDGKeASKGHYI 1438
Cdd:COG5560 707 ASKQMELWRLPMILIIHLKRFSSVRSFRDKIDDLVEYPID-DLDLSgVEYMVDDP--RLIYDLYAVDNHYGG-LSGGHYT 782
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 442629288 1439 TDVFHTGYSSWLRYDDSSVKPVSEKHVLQPHTprvpYLLYYRR 1481
Cdd:COG5560 783 AYARNFANNGWYLFDDSRITEVDPEDSVTSSA----YVLFYRR 821
|
|
| Peptidase_C19H |
cd02664 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1111-1480 |
5.37e-09 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239129 [Multi-domain] Cd Length: 327 Bit Score: 59.81 E-value: 5.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1111 GLTNRSNYCYINSILQALlgcspfynllrsipkqaavlsevktptvnammsFMTNFSSLPSglrLRLNNLNKGSQskgkd 1190
Cdd:cd02664 1 GLINLGNTCYMNSVLQAL---------------------------------FMAKDFRRQV---LSLNLPRLGDS----- 39
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1191 DFVGSDLQCDMAF--------EPTEIYKLwNDSREE-HVEGRQEDAEEFLGYVLNKLNdemleviKLIDKptpqqngqep 1261
Cdd:cd02664 40 QSVMKKLQLLQAHlmhtqrraEAPPDYFL-EASRPPwFTPGSQQDCSEYLRYLLDRLH-------TLIEK---------- 101
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1262 aepedggdvwqmicnnrnkgsvtrqtdfgrtpvsdIFRGELRSRLQREGEHSTDVIQPFFT-LQL---NIEKAASVKEAL 1337
Cdd:cd02664 102 -----------------------------------MFGGKLSTTIRCLNCNSTSARTERFRdLDLsfpSVQDLLNYFLSP 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1338 EILVGRDQLEGVTGSKTKQevvAWQQMTLEKLPVVLILHLKYFDY--RSDGCTKILKKVDFP--VELKIDAKILGSKKTS 1413
Cdd:cd02664 147 EKLTGDNQYYCEKCASLQD---AEKEMKVTGAPEYLILTLLRFSYdqKTHVREKIMDNVSINevLSLPVRVESKSSESPL 223
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1414 QKQRA--------------YRLFAVVYHDGKEASKGHY------ITDVFHTGYS--------------SWLRYDDS---S 1456
Cdd:cd02664 224 EKKEEesgddgelvtrqvhYRLYAVVVHSGYSSESGHYftyardQTDADSTGQEcpepkdaeendeskNWYLFNDSrvtF 303
|
410 420
....*....|....*....|....
gi 442629288 1457 VKPVSEKHVLQPHTPRVPYLLYYR 1480
Cdd:cd02664 304 SSFESVQNVTSRFPKDTPYILFYE 327
|
|
| Peptidase_C19F |
cd02662 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1111-1479 |
7.15e-09 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239127 [Multi-domain] Cd Length: 240 Bit Score: 58.15 E-value: 7.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1111 GLTNRSNYCYINSILQALlgcspfynllrsipkqaavlsevktptvnammsfmtnfSSLPSgLRLRLNNLNKgsqskgkd 1190
Cdd:cd02662 1 GLVNLGNTCFMNSVLQAL--------------------------------------ASLPS-LIEYLEEFLE-------- 33
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1191 dfvgsdlqcdmafepteiyklwndsreehvegrQEDAEEFLGYVLNKLNdemleviklidkptpqqngQEPAEPEDGGDV 1270
Cdd:cd02662 34 ---------------------------------QQDAHELFQVLLETLE-------------------QLLKFPFDGLLA 61
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1271 WQMICNNRNKGSVTRQTDFGRTpvsdifrgELRSRLQREGEHSTDviqpfftlqlniekaasvKEALEILVGRDQLEGVT 1350
Cdd:cd02662 62 SRIVCLQCGESSKVRYESFTML--------SLPVPNQSSGSGTTL------------------EHCLDDFLSTEIIDDYK 115
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1351 GSKTKQEVVawqqmtleKLPVVLILHLKyfdyRS--DGCTKILK---KVDFPVELKidakilgskktsqkQRAYRLFAVV 1425
Cdd:cd02662 116 CDRCQTVIV--------RLPQILCIHLS----RSvfDGRGTSTKnscKVSFPERLP--------------KVLYRLRAVV 169
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442629288 1426 YHDGkEASKGHYIT--------------------DVFHTGYSSWLRYDDSSVKPVSEKHVLQphTPRVpYLLYY 1479
Cdd:cd02662 170 VHYG-SHSSGHYVCyrrkplfskdkepgsfvrmrEGPSSTSHPWWRISDTTVKEVSESEVLE--QKSA-YMLFY 239
|
|
| Peptidase_C19L |
cd02668 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1111-1463 |
7.43e-09 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239133 [Multi-domain] Cd Length: 324 Bit Score: 59.36 E-value: 7.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1111 GLTNRSNYCYINSILQALLGCSPFYNLLRSIPKQAAVLSEVKTPTVN--------------AMMSFmtNFSSL--PSGL- 1173
Cdd:cd02668 1 GLKNLGATCYVNSFLQLWFMNLEFRKAVYECNSTEDAELKNMPPDKPhepqtiidqlqlifAQLQF--GNRSVvdPSGFv 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1174 -RLRLNNlnkgsqskgkddfvgsdlqcdmafepteiyklwndsreehveGRQEDAEEFLGYVLNKLNDEMLeviklidkp 1252
Cdd:cd02668 79 kALGLDT------------------------------------------GQQQDAQEFSKLFLSLLEAKLS--------- 107
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1253 tpQQNGQEpaepedggdvwqmicnnrnkgsvtrqtdfGRTPVSDIFRGELR-----SRLQREGEHSTDviqpFFTLQLNI 1327
Cdd:cd02668 108 --KSKNPD-----------------------------LKNIVQDLFRGEYSyvtqcSKCGRESSLPSK----FYELELQL 152
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1328 EKAASVKEAL------EILVGRDQLEGVT-GSKTKqevvAWQQMTLEKLPVVLILHLKYFDYRSDGCTKilKK----VDF 1396
Cdd:cd02668 153 KGHKTLEECIdeflkeEQLTGDNQYFCEScNSKTD----ATRRIRLTTLPPTLNFQLLRFVFDRKTGAK--KKlnasISF 226
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442629288 1397 PVELKIDAKILGSKktsQKQRAYRLFAVVYHDGKEASKGHYITDV--FHTGysSWLRYDDSSVKPVSEK 1463
Cdd:cd02668 227 PEILDMGEYLAESD---EGSYVYELSGVLIHQGVSAYSGHYIAHIkdEQTG--EWYKFNDEDVEEMPGK 290
|
|
| Peptidase_C19J |
cd02666 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1109-1479 |
5.23e-07 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239131 [Multi-domain] Cd Length: 343 Bit Score: 53.65 E-value: 5.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1109 PRGLTNRSNYCYINSILQALLGCSPFYNLLRSIPK-----QAAVLSEVKTPTVNAMMSFMTNFSSLPSGLRLRLNnlnkg 1183
Cdd:cd02666 1 PAGLDNIGNTCYLNSLLQYFFTIKPLRDLVLNFDEskaelASDYPTERRIGGREVSRSELQRSNQFVYELRSLFN----- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1184 sqskgkdDFVGSDLQCdmaFEPTEiyklwndsREEHVEGRQEDAEEFLGYVLnkLNDEMLEViklidkptPQQNGQEPAE 1263
Cdd:cd02666 76 -------DLIHSNTRS---VTPSK--------ELAYLALRQQDVTECIDNVL--FQLEVALE--------PISNAFAGPD 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1264 PEDGGDVWQMICNNRNKGsvTRQTDfgrTPVSDIFRGELRSRLQRegehstdviqpFFTLQLNIEK----------AASV 1333
Cdd:cd02666 128 TEDDKEQSDLIKRLFSGK--TKQQL---VPESMGNQPSVRTKTER-----------FLSLLVDVGKkgreivvllePKDL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1334 KEALEILVGRDQLEGVTGskTKQEVVAWQQMTLEKLPVVLILHLKYFDYRSDGCTKILKKVDFPVELKIDAKI--LGSKK 1411
Cdd:cd02666 192 YDALDRYFDYDSLTKLPQ--RSQVQAQLAQPLQRELISMDRYELPSSIDDIDELIREAIQSESSLVRQAQNELaeLKHEI 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442629288 1412 TSQ----KQRAYRLFAVVYHDGkEASKGHYITDVFHTGYSSWLRYDDSSV--KPVSEKhVLQPHTPRV-PYLLYY 1479
Cdd:cd02666 270 EKQfddlKSYGYRLHAVFIHRG-EASSGHYWVYIKDFEENVWRKYNDETVtvVPASEV-FLFTLGNTAtPYFLVY 342
|
|
| Peptidase_C19Q |
cd02673 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1216-1479 |
5.27e-06 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239138 [Multi-domain] Cd Length: 245 Bit Score: 49.45 E-value: 5.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1216 REEHVEGRQEDAEEFLGYVLNKLNDEMlEVIKLIDKPTPQQNGQ-EPAEP-EDGGDVWQMICNNRNKGSVTRQTDFGRTP 1293
Cdd:cd02673 25 NTEFDNDDQQDAHEFLLTLLEAIDDIM-QVNRTNVPPSNIEIKRlNPLEAfKYTIESSYVCIGCSFEENVSDVGNFLDVS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1294 VSDIFRGELrsrlqregehsTDVIQPFFTLqLNIEKAASvkealeilvgrdqlegvtGSKTKQEVVAWQQMTLeklPVVL 1373
Cdd:cd02673 104 MIDNKLDID-----------ELLISNFKTW-SPIEKDCS------------------SCKCESAISSERIMTF---PECL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1374 ILHLKYFDYRSdGCTKILKKvdfpvelkiDAKILgsKKTSQKQRAYRLFAVVYHDGKEASKGHYIT---DVFHTgySSWL 1450
Cdd:cd02673 151 SINLKRYKLRI-ATSDYLKK---------NEEIM--KKYCGTDAKYSLVAVICHLGESPYDGHYIAytkELYNG--SSWL 216
|
250 260
....*....|....*....|....*....
gi 442629288 1451 RYDDSSVKPVSEKHVLQPHTpRVPYLLYY 1479
Cdd:cd02673 217 YCSDDEIRPVSKNDVSTNAR-SSGYLIFY 244
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| Peptidase_C19M |
cd02669 |
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ... |
1111-1460 |
6.89e-06 |
|
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.
Pssm-ID: 239134 [Multi-domain] Cd Length: 440 Bit Score: 50.39 E-value: 6.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1111 GLTNRSNYCYINSILQALLGCSPFYNLLrsipkqaavLSEvktptvnammSFMTNFSSLPSGLRLRLNNLnkgsqskgkd 1190
Cdd:cd02669 121 GLNNIKNNDYANVIIQALSHVKPIRNFF---------LLY----------ENYENIKDRKSELVKRLSEL---------- 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1191 dfvgsdlqcdmafepteIYKLWNdSR--EEHVE------------------GRQEDAEEFLGYVLNKLNdemleviklid 1250
Cdd:cd02669 172 -----------------IRKIWN-PRnfKGHVSphellqavskvskkkfsiTEQSDPVEFLSWLLNTLH----------- 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1251 kptpqqngqepaepedggdvwqmICNNRNKGSVTRQtdfgrtpVSDIFRGELRSRLQREGEHSTDVIQ------------ 1318
Cdd:cd02669 223 -----------------------KDLGGSKKPNSSI-------IHDCFQGKVQIETQKIKPHAEEEGSkdkffkdsrvkk 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442629288 1319 ----PFFTLQLNIEKAASVKEALE------ILVGrDQLEGVTGSKTKQEVVAWQQMTLEKLPVVLILHLKYFDyRSDGct 1388
Cdd:cd02669 273 tsvsPFLLLTLDLPPPPLFKDGNEeniipqVPLK-QLLKKYDGKTETELKDSLKRYLISRLPKYLIFHIKRFS-KNNF-- 348
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442629288 1389 kILKK----VDFPVELKIDAKILGSKKTSQKQRA-YRLFAVVYHDGKEASKGHYITDVFHTGYSSWLRYDDSSVKPV 1460
Cdd:cd02669 349 -FKEKnptiVNFPIKNLDLSDYVHFDKPSLNLSTkYNLVANIVHEGTPQEDGTWRVQLRHKSTNKWFEIQDLNVKEV 424
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