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Conserved domains on  [gi|442630385|ref|NP_001261442|]
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Blimp-1, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 120-262 2.00e-63

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


:

Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 211.03  E-value: 2.00e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  120 KTLPRSLTLKSSMVystpNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYP-NDKNKARYFWRvqgtrhitygnikIFKD-D 197
Cdd:cd19187     1 ASLPRNLTLKYSSV----GREVLGVWSSDYIPRGTRFGPLVGEIYTNDPvPKGANRKYFWR-------------IYSNgE 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442630385  198 DYYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRL 262
Cdd:cd19187    64 FYHYIDGFDPSKSNWMRYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
zf-H2C2_2 pfam13465
Zinc-finger double domain;
904-929 6.27e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 6.27e-06
                           10        20
                   ....*....|....*....|....*.
gi 442630385   904 NLKVHLRTHSGERPFKCNVCTKSFTQ 929
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 938-1020 6.37e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 6.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  938 LVHTGEKPHQCDI--CKKRFSSTSNLKTHlRLHSGqkpyacdlCPQKFTQFVHLKLHKRLHTNDRPYVCQGCDKKYISAS 1015
Cdd:COG5189   342 LKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLN 412


                  ....*
gi 442630385 1016 GLRTH 1020
Cdd:COG5189   413 GLKYH 417
zf-C2HE super family cl24751
C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in ...
 871-912 2.92e-03

C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states.


The actual alignment was detected with superfamily member pfam16278:

Pssm-ID: 465082  Cd Length: 60  Bit Score: 37.27  E-value: 2.92e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 442630385   871 SRGYRSLPYPLKKKDgkmhYECNVCCKTFGQLSNLKVHLRTH 912
Cdd:pfam16278   20 KIELLPSEVLLLKTP----LKCHRCGNFGNNFPKLKAHLEEH 57
 
Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 120-262 2.00e-63

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 211.03  E-value: 2.00e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  120 KTLPRSLTLKSSMVystpNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYP-NDKNKARYFWRvqgtrhitygnikIFKD-D 197
Cdd:cd19187     1 ASLPRNLTLKYSSV----GREVLGVWSSDYIPRGTRFGPLVGEIYTNDPvPKGANRKYFWR-------------IYSNgE 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442630385  198 DYYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRL 262
Cdd:cd19187    64 FYHYIDGFDPSKSNWMRYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 133-260 5.22e-11

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 61.20  E-value: 5.22e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385    133 VYSTPNVKtEGVWSSGVIPRGTRFGPFEG---------IPTSNYPNDKNKARYFWRVQGTrhitygnikifkdddyYYLD 203
Cdd:smart00317    5 VFKSPGKG-WGVRATEDIPKGEFIGEYVGeiitseeaeERPKAYDTDGAKAFYLFDIDSD----------------LCID 67

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 442630385    204 GsdRSQSNWMRYVA-SAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFAS 260
Cdd:smart00317   68 A--RRKGNLARFINhSCEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYAN 123
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 143-254 2.10e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 53.68  E-value: 2.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385   143 GVWSSGVIPRGTRFGPF-EGIPTSnyPNDKNKARYFWRVQGTRHITYGNIKIFKDDDYYYLDGSDRSQSNWMRYV-ASAY 220
Cdd:pfam00856    3 GLFATEDIPKGEFIGEYvEVLLIT--KEEADKRELLYYDKLELRLWGPYLFTLDEDSEYCIDARALYYGNWARFInHSCD 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 442630385   221 SLSVMNLVACQHQENIYFYTTRDILPNEELMVWY 254
Cdd:pfam00856   81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDY 114
zf-H2C2_2 pfam13465
Zinc-finger double domain;
904-929 6.27e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 6.27e-06
                           10        20
                   ....*....|....*....|....*.
gi 442630385   904 NLKVHLRTHSGERPFKCNVCTKSFTQ 929
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 938-1020 6.37e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 6.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  938 LVHTGEKPHQCDI--CKKRFSSTSNLKTHlRLHSGqkpyacdlCPQKFTQFVHLKLHKRLHTNDRPYVCQGCDKKYISAS 1015
Cdd:COG5189   342 LKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLN 412


                  ....*
gi 442630385 1016 GLRTH 1020
Cdd:COG5189   413 GLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
932-957 2.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.50e-04
                           10        20
                   ....*....|....*....|....*.
gi 442630385   932 HLQKHHLVHTGEKPHQCDICKKRFSS 957
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
150-250 4.99e-04

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 41.49  E-value: 4.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  150 IPRGTRFGPFEGIPtsnYPNDKNKARYfwrVQGTRHITYgnikIFKDDDYYYLDGSDRSqsNWMRYVA-SAYSlsvmNLV 228
Cdd:COG2940    26 IPKGTLIGEYPGEV---ITWAEAERRE---PHKEPLHTY----LFELDDDGVIDGALGG--NPARFINhSCDP----NCE 89

                          90       100
                  ....*....|....*....|..
gi 442630385  229 ACQHQENIYFYTTRDILPNEEL 250
Cdd:COG2940    90 ADEEDGRIFIVALRDIAAGEEL 111
zf-C2HE pfam16278
C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in ...
 871-912 2.92e-03

C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states.


Pssm-ID: 465082  Cd Length: 60  Bit Score: 37.27  E-value: 2.92e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 442630385   871 SRGYRSLPYPLKKKDgkmhYECNVCCKTFGQLSNLKVHLRTH 912
Cdd:pfam16278   20 KIELLPSEVLLLKTP----LKCHRCGNFGNNFPKLKAHLEEH 57
 
Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 120-262 2.00e-63

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 211.03  E-value: 2.00e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  120 KTLPRSLTLKSSMVystpNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYP-NDKNKARYFWRvqgtrhitygnikIFKD-D 197
Cdd:cd19187     1 ASLPRNLTLKYSSV----GREVLGVWSSDYIPRGTRFGPLVGEIYTNDPvPKGANRKYFWR-------------IYSNgE 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442630385  198 DYYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRL 262
Cdd:cd19187    64 FYHYIDGFDPSKSNWMRYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 119-263 9.76e-32

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 120.80  E-value: 9.76e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  119 DKTLPRSLTLKSSmvySTPNVKTeGVWSSGVIPRGTRFGPFEGIPTSnyPNDKNKARYFWrvqgtrhitygniKIFKDDD 198
Cdd:cd19193     1 RLTLPPGLSIKRS---SIPGAGL-GVWAEAPIPKGMVFGPYEGEIVE--DEEAADSGYSW-------------QIYKGGK 61

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442630385  199 -YYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLG 263
Cdd:cd19193    62 lSHYIDAKDESKSNWMRYVNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDEYAKELG 127
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 117-263 3.93e-26

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 104.85  E-value: 3.93e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  117 RADKTLPRSLTLKSSMVysTPNVkteGVWSSGVIPRGTRFGPFEGIPTSNYPNDKnkaryfWRVQGTRHITygniKIFKD 196
Cdd:cd19189     1 RARLSLPRQLYLRQSET--GAEV---GVWTKETIPVRTCFGPLIGQQSHSAEVAD------WTDKAAPHIW----KIYHN 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442630385  197 DDY-YYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLG 263
Cdd:cd19189    66 DVLeFCIITTDENECNWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 117-263 8.70e-24

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 97.81  E-value: 8.70e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  117 RADKTLPRSLTLKSSMVYSTpnvkteGVWSSGVIPRGTRFGPFEGIPTSNYPNDKNKARYFWRVQgtrhitygnikifKD 196
Cdd:cd19194     1 RARASLPLILQIFRFGETLG------GVFAKRRIPKRTQFGPLEGPLVKKSELKDNKIHPLELEE-------------DD 61

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442630385  197 DDYYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLG 263
Cdd:cd19194    62 GEDLYFDLSDENKCNWMMFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKVWYAASYAEFLG 128
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 122-254 1.34e-23

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 95.73  E-value: 1.34e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  122 LPRSLTLKSSMVYSTPnvktEGVWSSGVIPRGTRFGPFEGiptsnypndknkaryfwrvqgtrhitygnikifkdddyyy 201
Cdd:cd10534     1 LPAGLELVLSSIPEGG----LGVFARRTIPAGTRFGPLEG---------------------------------------- 36

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 442630385  202 ldgsdrsQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWY 254
Cdd:cd10534    37 -------VVNWMRFVRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWY 82
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 119-254 9.06e-23

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 94.82  E-value: 9.06e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  119 DKTLPRSLTLKSSMVYSTPNvkteGVWSSGVIPRGTRFGPFEGiptsnypnDKNKAR------YFWRVQgtrhitYGNIK 192
Cdd:cd19188     1 LMGLPEELELKPSAVDKTRI----GVWAKKSIPKGRKFGPFVG--------EKKKRSqvknnvYMWEIY------GPKRG 62

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442630385  193 IFkdddyyYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWY 254
Cdd:cd19188    63 WM------CVDASDPTKGNWLRYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWY 118
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 149-262 3.48e-21

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 90.30  E-value: 3.48e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  149 VIPRGTRFGPFEGIPTSNypnDKNKARYFWRVQGtrhitygnikifKDDDYYYLDGSDRSQSNWMRYVASAYSLSVMNLV 228
Cdd:cd19195    27 VIPKGHIFGPYEGQICTQ---DKSSGFFSWLIVD------------KNNRYKSIDGSDETKANWMRYVVISREEREQNLL 91

                          90       100       110
                  ....*....|....*....|....*....|....
gi 442630385  229 ACQHQENIYFYTTRDILPNEELMVWYCKDFASRL 262
Cdd:cd19195    92 AFQHSEQIYFRACRDIRPGEKLRVWYSEDYMKRL 125
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 143-254 9.00e-20

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 86.68  E-value: 9.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  143 GVWSSGVIPRGTRFGPFEG--IPTSNYP-NDKNKarYFWrvqgtrhitygniKIFKDDDY-YYLDGSDrSQSNWMRYVAS 218
Cdd:cd19198    21 GVFCKKTIPKGTRFGPFRGrvVNTSEIKtYDDNS--FMW-------------EIFEDGKLsHFIDGRG-STGNWMSYVNC 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 442630385  219 AYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWY 254
Cdd:cd19198    85 ARYAEEQNLIAIQCQGQIFYESCKEILQGQELLVWY 120
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 143-257 1.00e-19

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 86.65  E-value: 1.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  143 GVWSSGVIPRGTRFGPFEGIPTSNYPNdknkARYFWRVQGTrhitYGNIKifkdddyYYLDGSDRSQSNWMRYVASAYSL 222
Cdd:cd19200    27 GVWTKVRIEVGEKFGPFVGVQRSSVKD----PTYAWEIVDE----FGKVK-------FWIDASEPGTGNWMKYIRSAPSC 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 442630385  223 SVMNLVACQHQENIYFYTTRDILPNEELMVwYCKD 257
Cdd:cd19200    92 EQQNLMACQIDEQIYYKVVRDIQPGEELLL-YMKA 125
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 117-262 2.42e-18

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 82.08  E-value: 2.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  117 RADKTLPRSLTLKssmvysTPNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYpnDKNKARYFwrvqgtrhitygniKIF-K 195
Cdd:cd19199     2 RARSSLPDNLEIR------QLEDGSEGVFALVPLVKRTQFGPFEAKRVARL--DGFAVFPL--------------KVFeK 59

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442630385  196 DDDYYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRL 262
Cdd:cd19199    60 DGSVVYLDTSNEDDCNWMMFVRPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFYAKKM 126
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 122-260 4.70e-18

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 81.37  E-value: 4.70e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  122 LPRSLTLKSSmvySTPNVKTeGVWSSGVIPRGTRFGPFEGIPTSNYPNDKN--KARYFWRVqgtrhitYGNIKIFKdddy 199
Cdd:cd19191     1 LPDEVCLCTS---SIPGLGY-GICAAQRIPQGTWIGPFEGVLVSPEKQIGAvrNTQHLWEI-------YDQEGTLQ---- 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442630385  200 YYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFAS 260
Cdd:cd19191    66 HFIDGGDPSKSSWMRYIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYDDSYTS 126
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 122-263 2.47e-17

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 79.32  E-value: 2.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  122 LPRSLTLKSSmvySTPNVKTeGVWSSGVIPRGTRFGPFEG---IPTSNYPNDKNKarYFWRVqgtrHITYGNIKifkddd 198
Cdd:cd19196     1 LPSQVIIAQS---SIPGAGL-GVFSKTWIKEGTEMGPYTGrivSPEDVDPCKNNN--LMWEV----FNEDGTVS------ 64

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442630385  199 yYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLG 263
Cdd:cd19196    65 -HFIDASQENHRSWMTFVNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSYNTFLG 128
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 122-254 2.81e-14

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 70.78  E-value: 2.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  122 LPRSLTLKSSMVYSTpnvktEGVWSSGVIPRGTRFGPFEGipTSNYPNDKNKA---RYFWRVQGTrhitygnikifKDDD 198
Cdd:cd19190     5 VPDRFSLKSSKVQDG-----MGLYTARRVKKGEKFGPFAG--EKRMPNELDESmdpRLMWEVRGS-----------KGEV 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 442630385  199 YYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWY 254
Cdd:cd19190    67 LYILDASNPRHSNWLRFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGY 122
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 122-258 1.28e-13

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 68.53  E-value: 1.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  122 LPRSLTLKSSmvySTPNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYPNDKNKarYFWRVQGTRHitygnikifkdddYYY 201
Cdd:cd19201     3 LPGELELRKP---SQDAGRSGGVWAKQPLPEGTRFGPYPGKLVKEPLDPSYE--WKVEAQGSKG-------------GEG 64

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 442630385  202 LDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDF 258
Cdd:cd19201    65 LLLLTEDSGTWLKLVRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVLREPL 121
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 119-257 9.46e-13

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 67.21  E-value: 9.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  119 DKTLPRSLTLKSSmvySTPNVKTeGVWSSGVIPRGTRFGPFEGIP--TSNYPNdknkarYFWRVQGTRHITY---GNIKI 193
Cdd:cd19213    17 DIPIPSDFELRES---SIPGAGL-GVWAKRKIEAGERFGPYTGVQrsTLKDTN------FGWEQILNDVEVSsqeGCITK 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442630385  194 FKDD---DYYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVwYCKD 257
Cdd:cd19213    87 IVDDlgnEKFCVDAGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLV-YVKD 152
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 133-260 5.22e-11

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 61.20  E-value: 5.22e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385    133 VYSTPNVKtEGVWSSGVIPRGTRFGPFEG---------IPTSNYPNDKNKARYFWRVQGTrhitygnikifkdddyYYLD 203
Cdd:smart00317    5 VFKSPGKG-WGVRATEDIPKGEFIGEYVGeiitseeaeERPKAYDTDGAKAFYLFDIDSD----------------LCID 67

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 442630385    204 GsdRSQSNWMRYVA-SAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFAS 260
Cdd:smart00317   68 A--RRKGNLARFINhSCEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYAN 123
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 123-262 1.89e-10

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 59.75  E-value: 1.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  123 PRSLTLKSSMVYSTPnvKTEGVWSSGVIPRGTRFGPFEGIPTSNY--------PNDKNKARYFWRVQGTrhitygnikif 194
Cdd:cd19192     3 HRSLWRGGSKSVLTD--IFTSVVTTTDIPAGTIFGPCVLSFTLGYdiadialkTTDKRVVPYIFRVDTG----------- 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442630385  195 kdddyyyLDGSDRSQSNWMRYVASAYSLSVMNLVA-CQHQENIYFYTTRDILPNEELMVWYCKDFASRL 262
Cdd:cd19192    70 -------ACNGSSEPSDWLRLVQPARDRHEQNLEAfRKNEGQVYFRTLRRIRKGEELLVWYSDELAELL 131
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 143-253 4.83e-10

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 59.57  E-value: 4.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  143 GVWSSGVIPRGTRFGPFEGIPTSNYPNdknkARYFWRVQGTrhitYGNIKifkdddyYYLDGSDRSQSNWMRYVASAYSL 222
Cdd:cd19214    47 GIWTKRKIEVGEKFGPYVGEQRSNLKD----PSYGWEVLDE----FGNVK-------FCIDASQPDVGSWLKYIRFAGCY 111

                          90       100       110
                  ....*....|....*....|....*....|.
gi 442630385  223 SVMNLVACQHQENIYFYTTRDILPNEELMVW 253
Cdd:cd19214   112 DQHNLVACQINDQIFYRAVADIDPGEELLLF 142
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 150-260 7.30e-10

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 57.14  E-value: 7.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  150 IPRGTRFGPFEGIPTS-NYPNDknkaryfwrvqgtrHITYGNIKifKDDDY---YYLDGSDRSQSNWMRYVASAYSLSVM 225
Cdd:cd19197     1 IPAGLRLGPVPGIFKLgKYLSD--------------RKEPGNKK--KVRRVrgdYLVDESGSPATEWIGLVRAARNNQEQ 64

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 442630385  226 NLVACQHQEN--IYFYTTRDILPNEELMVWYCKDFAS 260
Cdd:cd19197    65 NLEAIADLPGgqIFYRALRDIQPGEELTVWYSNSLAQ 101
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 143-254 2.10e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 53.68  E-value: 2.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385   143 GVWSSGVIPRGTRFGPF-EGIPTSnyPNDKNKARYFWRVQGTRHITYGNIKIFKDDDYYYLDGSDRSQSNWMRYV-ASAY 220
Cdd:pfam00856    3 GLFATEDIPKGEFIGEYvEVLLIT--KEEADKRELLYYDKLELRLWGPYLFTLDEDSEYCIDARALYYGNWARFInHSCD 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 442630385   221 SLSVMNLVACQHQENIYFYTTRDILPNEELMVWY 254
Cdd:pfam00856   81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDY 114
zf-H2C2_2 pfam13465
Zinc-finger double domain;
904-929 6.27e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 6.27e-06
                           10        20
                   ....*....|....*....|....*.
gi 442630385   904 NLKVHLRTHSGERPFKCNVCTKSFTQ 929
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 118-253 9.31e-06

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 46.26  E-value: 9.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  118 ADKTLPRSLTLKSSMVYStpnvKTEGVWSSG-VIPRGTRFGPFEGiptsnypndknkaryfwrvQGTRHITYGNIKIFKD 196
Cdd:cd10520     1 ALRSLPPGLALGPSLAQE----ERLGVWCVGdALQKGTFLGPLEE-------------------ELESHDLTEGGSPRQE 57

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 442630385  197 DDYYYLDGSDRSQ-SNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVW 253
Cdd:cd10520    58 ESGQSGDVLACEQsSKWMRFACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLW 115
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 938-1020 6.37e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 6.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  938 LVHTGEKPHQCDI--CKKRFSSTSNLKTHlRLHSGqkpyacdlCPQKFTQFVHLKLHKRLHTNDRPYVCQGCDKKYISAS 1015
Cdd:COG5189   342 LKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLN 412


                  ....*
gi 442630385 1016 GLRTH 1020
Cdd:COG5189   413 GLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
932-957 2.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.50e-04
                           10        20
                   ....*....|....*....|....*.
gi 442630385   932 HLQKHHLVHTGEKPHQCDICKKRFSS 957
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
960-985 3.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 3.74e-04
                           10        20
                   ....*....|....*....|....*.
gi 442630385   960 NLKTHLRLHSGQKPYACDLCPQKFTQ 985
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
916-999 4.07e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 4.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  916 RPFKCNVCTKSFTQLAHLQKHHLVHTGEKPHQC--DICKKRFSSTSNLKTHLRLHSGQKPYAC--DLCPQKFTQFVHLKL 991
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLS 111


                  ....*...
gi 442630385  992 HKRLHTND 999
Cdd:COG5048   112 SSSSNSND 119
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
150-250 4.99e-04

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 41.49  E-value: 4.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  150 IPRGTRFGPFEGIPtsnYPNDKNKARYfwrVQGTRHITYgnikIFKDDDYYYLDGSDRSqsNWMRYVA-SAYSlsvmNLV 228
Cdd:COG2940    26 IPKGTLIGEYPGEV---ITWAEAERRE---PHKEPLHTY----LFELDDDGVIDGALGG--NPARFINhSCDP----NCE 89

                          90       100
                  ....*....|....*....|..
gi 442630385  229 ACQHQENIYFYTTRDILPNEEL 250
Cdd:COG2940    90 ADEEDGRIFIVALRDIAAGEEL 111
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 946-968 7.62e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 7.62e-04
                           10        20
                   ....*....|....*....|...
gi 442630385   946 HQCDICKKRFSSTSNLKTHLRLH 968
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 918-940 1.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.56e-03
                           10        20
                   ....*....|....*....|...
gi 442630385   918 FKCNVCTKSFTQLAHLQKHHLVH 940
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2HE pfam16278
C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in ...
 871-912 2.92e-03

C2HE / C2H2 / C2HC zinc-binding finger; zf-C2HE is an unusual zinc-binding domain found in fungi, plants and metazoa. It is often found at the C-terminus of HIT-domain-containing proteins, pfam01230. In fungi the fourth ligand is a Glu, in plants it is Cys and in metazoans it is usually a His. The fourth ligand is often mutated in neurogenerative disease-states.


Pssm-ID: 465082  Cd Length: 60  Bit Score: 37.27  E-value: 2.92e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 442630385   871 SRGYRSLPYPLKKKDgkmhYECNVCCKTFGQLSNLKVHLRTH 912
Cdd:pfam16278   20 KIELLPSEVLLLKTP----LKCHRCGNFGNNFPKLKAHLEEH 57
zf-H2C2_2 pfam13465
Zinc-finger double domain;
988-1013 4.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 4.66e-03
                           10        20
                   ....*....|....*....|....*.
gi 442630385   988 HLKLHKRLHTNDRPYVCQGCDKKYIS 1013
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SSL1 COG5151
RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit ...
 917-1010 7.85e-03

RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227480 [Multi-domain]  Cd Length: 421  Bit Score: 40.37  E-value: 7.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  917 PFKCNVCTKSFTQLAHLQK--HHL--------VHTGEKPH--QCDICKKRFSSTSNLKTHLRLHSGQkpYACDLCPQKFT 984
Cdd:COG5151   322 PISCPICSLQLILSTHLARsyHHLyplkpfveKPEGTNPKstHCFVCQGPFPKPPVSPFDESTSSGR--YQCELCKSTFC 399

                          90       100
                  ....*....|....*....|....*.
gi 442630385  985 QFVHLKLHKRLHTndrpyvCQGCDKK 1010
Cdd:COG5151   400 SDCDVFIHETLHF------CIGCELP 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
828-1029 9.59e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 9.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  828 PLMQPLTPLQRLSPLRISPPSSLSPDGNSCprsgSPLSPNSLASRGYRSLPYPLKKKDGKMHYECNVCCKTFGQLSNLKV 907
Cdd:COG5048   203 SPLSSSYSIPSSSSDQNLENSSSSLPLTTN----SQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNES 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442630385  908 HLRTHSGER-PFKCNVCTKSFTQLAHLQKH--HLVHTGE--KPHQCDI--CKKRFSSTSNLKTHLRLHSGQKPYACDL-- 978
Cdd:COG5048   279 DSSSEKGFSlPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLln 358

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442630385  979 CPQKFTQFVHLKLHKRLH-----TNDRPYVCQG------CDKKYISASGLRTH-WKTTSCKPN 1029
Cdd:COG5048   359 SSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnscirnFKRDSNLSLHIITHlSFRPYNCKN 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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