NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|442622046|ref|NP_001263138|]
View 

spn-F, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Zn-C2H2_spn-F cd21971
C2H2-type zinc binding domain found in Drosophila melanogaster Spindle-F (Spn-F) and similar ...
 310-339 1.08e-11

C2H2-type zinc binding domain found in Drosophila melanogaster Spindle-F (Spn-F) and similar proteins; spn-F is the central mediator of IK2 kinase-dependent dendrite pruning in drosophila sensory neurons. It acts downstream of IKK-related kinase Ik2 in the same pathway for dendrite pruning. Spn-F is a coil-coiled protein containing a C2H2-type zinc binding domain.


:

Pssm-ID: 412017  Cd Length: 30  Bit Score: 58.69  E-value: 1.08e-11
                         10        20        30
                 ....*....|....*....|....*....|
gi 442622046 310 EKTCPMCGKQYSSQVSFNAFREHVEMHFID 339
Cdd:cd21971    1 ERTCPMCGKQFSDQVSFHEFREHVEMHFID 30
 
Name Accession Description Interval E-value
Zn-C2H2_spn-F cd21971
C2H2-type zinc binding domain found in Drosophila melanogaster Spindle-F (Spn-F) and similar ...
 310-339 1.08e-11

C2H2-type zinc binding domain found in Drosophila melanogaster Spindle-F (Spn-F) and similar proteins; spn-F is the central mediator of IK2 kinase-dependent dendrite pruning in drosophila sensory neurons. It acts downstream of IKK-related kinase Ik2 in the same pathway for dendrite pruning. Spn-F is a coil-coiled protein containing a C2H2-type zinc binding domain.


Pssm-ID: 412017  Cd Length: 30  Bit Score: 58.69  E-value: 1.08e-11
                         10        20        30
                 ....*....|....*....|....*....|
gi 442622046 310 EKTCPMCGKQYSSQVSFNAFREHVEMHFID 339
Cdd:cd21971    1 ERTCPMCGKQFSDQVSFHEFREHVEMHFID 30
Zn-C2H2_12 pfam18112
Autophagy receptor zinc finger-C2H2 domain; This domain is found in calcium-binding and ...
 311-337 5.16e-11

Autophagy receptor zinc finger-C2H2 domain; This domain is found in calcium-binding and coiled-coil domain 2/NDP25 (CALCOCO2/NDP25) found in Homo sapiens. CALCOCO2/NDP25 is an ubiquitin-binding autophagy receptor involved in the selective autophagic degradation of invading pathogens. This domain is a typical C2H2-type zinc finger which specifically recognizes mono-ubiquitin or poly-ubiquitin chain. The overall ubiquitin-binding mode utilizes the C-terminal alpha-helix to interact with the solvent-exposed surface of the central beta-sheet of ubiquitin, similar to that observed in the RABGEF1/Rabex-5 or POLN/Pol-eta zinc finger.


Pssm-ID: 407946  Cd Length: 27  Bit Score: 56.88  E-value: 5.16e-11
                          10        20
                  ....*....|....*....|....*..
gi 442622046  311 KTCPMCGKQYSSQVSFNAFREHVEMHF 337
Cdd:pfam18112   1 KECPLCGEMFSPNIDQSEFEEHVESHF 27
 
Name Accession Description Interval E-value
Zn-C2H2_spn-F cd21971
C2H2-type zinc binding domain found in Drosophila melanogaster Spindle-F (Spn-F) and similar ...
 310-339 1.08e-11

C2H2-type zinc binding domain found in Drosophila melanogaster Spindle-F (Spn-F) and similar proteins; spn-F is the central mediator of IK2 kinase-dependent dendrite pruning in drosophila sensory neurons. It acts downstream of IKK-related kinase Ik2 in the same pathway for dendrite pruning. Spn-F is a coil-coiled protein containing a C2H2-type zinc binding domain.


Pssm-ID: 412017  Cd Length: 30  Bit Score: 58.69  E-value: 1.08e-11
                         10        20        30
                 ....*....|....*....|....*....|
gi 442622046 310 EKTCPMCGKQYSSQVSFNAFREHVEMHFID 339
Cdd:cd21971    1 ERTCPMCGKQFSDQVSFHEFREHVEMHFID 30
Zn-C2H2_12 pfam18112
Autophagy receptor zinc finger-C2H2 domain; This domain is found in calcium-binding and ...
 311-337 5.16e-11

Autophagy receptor zinc finger-C2H2 domain; This domain is found in calcium-binding and coiled-coil domain 2/NDP25 (CALCOCO2/NDP25) found in Homo sapiens. CALCOCO2/NDP25 is an ubiquitin-binding autophagy receptor involved in the selective autophagic degradation of invading pathogens. This domain is a typical C2H2-type zinc finger which specifically recognizes mono-ubiquitin or poly-ubiquitin chain. The overall ubiquitin-binding mode utilizes the C-terminal alpha-helix to interact with the solvent-exposed surface of the central beta-sheet of ubiquitin, similar to that observed in the RABGEF1/Rabex-5 or POLN/Pol-eta zinc finger.


Pssm-ID: 407946  Cd Length: 27  Bit Score: 56.88  E-value: 5.16e-11
                          10        20
                  ....*....|....*....|....*..
gi 442622046  311 KTCPMCGKQYSSQVSFNAFREHVEMHF 337
Cdd:pfam18112   1 KECPLCGEMFSPNIDQSEFEEHVESHF 27
Zn-C2H2_CALCOCO1_TAX1BP1_like cd21965
autophagy receptor zinc finger-C2H2 domain found in calcium-binding and coiled-coil ...
 313-336 6.31e-08

autophagy receptor zinc finger-C2H2 domain found in calcium-binding and coiled-coil domain-containing proteins, TAX1BP1 and similar proteins; The family includes calcium-binding and coiled-coil domain-containing proteins (CALCOCO1 and CALCOCO2), TAX1BP1 and similar proteins. CALCOCO1, also called calphoglin, or coiled-coil coactivator protein, or Sarcoma antigen NY-SAR-3, functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). CALCOCO2, also called antigen nuclear dot 52 kDa protein, or nuclear domain 10 protein NDP52, or nuclear domain 10 protein 52, or nuclear dot protein 52, is an ubiquitin-binding autophagy receptor involved in the selective autophagic degradation of invading pathogens. TAX1BP1, also called TRAF6-binding protein (T6BP), is a novel ubiquitin-binding adaptor protein involved in the negative regulation of the NF-kappaB transcription factor, a key player in inflammatory responses, immunity and tumorigenesis. The family also includes Drosophila melanogaster Spindle-F (Spn-F) that is the central mediator of IK2 kinase-dependent dendrite pruning in drosophila sensory neurons. This model corresponds to the C2H2-type zinc binding domain found in family members. It is a typical C2H2-type zinc finger which specifically recognizes mono-ubiquitin or poly-ubiquitin chain. The overall ubiquitin-binding mode utilizes the C-terminal alpha-helix to interact with the solvent-exposed surface of the central beta-sheet of ubiquitin, similar to that observed in the RABGEF1/Rabex-5 or POLN/Pol-eta zinc finger.


Pssm-ID: 412012  Cd Length: 24  Bit Score: 47.95  E-value: 6.31e-08
                         10        20
                 ....*....|....*....|....
gi 442622046 313 CPMCGKQYSSQVSFNAFREHVEMH 336
Cdd:cd21965    1 CPICNKQFPPQVDQEAFEDHVESH 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH