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Conserved domains on  [gi|472339083|ref|NP_001264260|]
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keratin-associated protein 9-6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 37-160 8.30e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.51  E-value: 8.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339083   37 CCQPSCCVSSCCQPYC-HPTCCQNTCCRTTCCQPTCvTSCCQPSCCSTPCYQPICCGSSCCGQTSCGSSCGQSSSCAPVY 115
Cdd:pfam01500  24 CCQPCCCQSSCCRPSCcQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRW 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 472339083  116 CRRTCYHPTTVCLPGCLNQSCGSSCCQ------PCYCPACCVSSCCQHSCC 160
Cdd:pfam01500 103 CRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCCRPACC 153
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 37-160 8.30e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.51  E-value: 8.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339083   37 CCQPSCCVSSCCQPYC-HPTCCQNTCCRTTCCQPTCvTSCCQPSCCSTPCYQPICCGSSCCGQTSCGSSCGQSSSCAPVY 115
Cdd:pfam01500  24 CCQPCCCQSSCCRPSCcQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRW 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 472339083  116 CRRTCYHPTTVCLPGCLNQSCGSSCCQ------PCYCPACCVSSCCQHSCC 160
Cdd:pfam01500 103 CRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCCRPACC 153
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 37-160 8.30e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.51  E-value: 8.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339083   37 CCQPSCCVSSCCQPYC-HPTCCQNTCCRTTCCQPTCvTSCCQPSCCSTPCYQPICCGSSCCGQTSCGSSCGQSSSCAPVY 115
Cdd:pfam01500  24 CCQPCCCQSSCCRPSCcQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRW 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 472339083  116 CRRTCYHPTTVCLPGCLNQSCGSSCCQ------PCYCPACCVSSCCQHSCC 160
Cdd:pfam01500 103 CRPDCRVEGTCLPPCCVVSCTPPTCCQlhhaqaSCCRPSYCGQSCCRPACC 153
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
37-79 4.81e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.99  E-value: 4.81e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 472339083   37 CCQPSCCVSSCCQPYC-HPTCCQNTCCRTTCCQPTC-VTSCCQPS 79
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCcQPSCCQPSCCQPSCCRPSCcRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
30-70 1.39e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 43.14  E-value: 1.39e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 472339083   30 TTCSSTPCCQPSCCVSSCCQPY-CHPTCCQNTCCRTTCCQPT 70
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPScCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
56-96 2.11e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 42.37  E-value: 2.11e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 472339083   56 CCQNTCCRTTCCQPtcvtSCCQPSCCSTPCYQPICCGSSCC 96
Cdd:pfam13885   1 CCQPSCCQPSCCQP----SCCQPSCCQPSCCQPSCCRPSCC 37
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 2-96 5.21e-05

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 41.32  E-value: 5.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472339083    2 THCCSPGCQPTCCRTTCCRTTCwQPTIVTTCSSTPCCQPSCCVSSCCQP----------------YCHPTCCQNTCCRTT 65
Cdd:pfam01500  38 SCCQTSCCQPTTFQSSCCRPTC-QPCCQTSCCQPTCCQTSSCQTGCGGIgygqegssgavssrtrWCRPDCRVEGTCLPP 116

                          90       100       110
                  ....*....|....*....|....*....|..
gi 472339083   66 CCQPTCV-TSCCQPSCCSTPCYQPICCGSSCC 96
Cdd:pfam01500 117 CCVVSCTpPTCCQLHHAQASCCRPSYCGQSCC 148
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
80-124 2.78e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 34.28  E-value: 2.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 472339083   80 CCSTPCYQPICCGSSCCGQTSCGSSCGQSSSCAPVYCRRTCYHPT 124
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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