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Conserved domains on  [gi|545686629|ref|NP_001269955|]
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beta-soluble NSF attachment protein isoform d [Homo sapiens]

Protein Classification

soluble NSF attachment family protein( domain architecture ID 12171651)

soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) is involved in intracellular membrane trafficking, similar to human alpha-SNAP which acts as an adaptor between SNARE (integral membrane SNAP receptor) and NSF; contains TPR repeats

CATH:  1.25.40.10
Gene Ontology:  GO:0005483|GO:0000149
PubMed:  17634982|11536358
SCOP:  4001344

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SNAP pfam14938
Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are ...
 20-193 1.82e-90

Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus. They act as adaptors between SNARE (integral membrane SNAP receptor) proteins and NSF (N-ethylmaleimide-sensitive factor). They are structurally similar to TPR repeats.


:

Pssm-ID: 405606 [Multi-domain]  Cd Length: 273  Bit Score: 266.36  E-value: 1.82e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545686629   20 KGRFTIAAKHHITIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIYEQVGANTM 99
Cdd:pfam14938  99 MGRFRRAAKHKKEIAELYEQELGDLEKAIEAYEQAADWYEGEGASALANKCYLKVADLSAELEDYPKAIEIYEKVAKNSL 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545686629  100 DNPLLKYSAKDYFFKAALCHF-IVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSEAYTEAVKEFDSISRL 178
Cdd:pfam14938 179 ENNLLKYSVKEYFLKAGLCHLaAGDLVAAQRALERYEELDPSFADTREYKLLNDLLEAVEEGDVEAFTDAVFEFDQISKL 258

                         170
                  ....*....|....*
gi 545686629  179 DQWLTTMLLRIKKSI 193
Cdd:pfam14938 259 DKWKTTILLKIKNTI 273
 
Name Accession Description Interval E-value
SNAP pfam14938
Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are ...
 20-193 1.82e-90

Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus. They act as adaptors between SNARE (integral membrane SNAP receptor) proteins and NSF (N-ethylmaleimide-sensitive factor). They are structurally similar to TPR repeats.


Pssm-ID: 405606 [Multi-domain]  Cd Length: 273  Bit Score: 266.36  E-value: 1.82e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545686629   20 KGRFTIAAKHHITIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIYEQVGANTM 99
Cdd:pfam14938  99 MGRFRRAAKHKKEIAELYEQELGDLEKAIEAYEQAADWYEGEGASALANKCYLKVADLSAELEDYPKAIEIYEKVAKNSL 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545686629  100 DNPLLKYSAKDYFFKAALCHF-IVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSEAYTEAVKEFDSISRL 178
Cdd:pfam14938 179 ENNLLKYSVKEYFLKAGLCHLaAGDLVAAQRALERYEELDPSFADTREYKLLNDLLEAVEEGDVEAFTDAVFEFDQISKL 258

                         170
                  ....*....|....*
gi 545686629  179 DQWLTTMLLRIKKSI 193
Cdd:pfam14938 259 DKWKTTILLKIKNTI 273
SNAP cd15832
Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the ...
 20-193 9.85e-88

Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the soluble NSF attachment protein (SNAP) family are involved in intracellular membrane trafficking, including vesicular transport between the endoplasmic reticulum and Golgi apparatus. Higher eukaryotes contain three isoforms of SNAPs: alpha, beta, and gamma. Alpha-SNAP is universally present in eukaryotes and acts as an adaptor protein between SNARE (integral membrane SNAP receptor) and NSF for recruitment to the 20S complex. Beta-SNAP is brain-specific and shares high sequence identity (about 85%) with alpha-SNAP. Gamma-SNAP is weakly related (about 20-25% identity) to the two other isoforms, and is ubiquitous. It may help regulate the activity of the 20S complex. The X-ray structures of vertebrate gamma-SNAP and yeast Sec17, a SNAP family member, show similar all-helical structures consisting of an N-terminal extended twisted sheet of four Tetratricopeptide repeat (TPR)-like helical hairpins and a C-terminal helical bundle.


Pssm-ID: 276937 [Multi-domain]  Cd Length: 278  Bit Score: 259.43  E-value: 9.85e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545686629  20 KGRFTIAAKHHITIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIYEQVGANTM 99
Cdd:cd15832  104 MGRFRQAAKHLKEIAELYENELGDLDKAIEAYEQAADYYEGEGANSLANKCYLKVADLAAQLEDYDKAIEIYEQVARSSL 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545686629 100 DNPLLKYSAKDYFFKAALCHF-IVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSEAYTEAVKEFDSISRL 178
Cdd:cd15832  184 ENNLLKYSAKDYFLKAGLCHLaAGDVVAAQRALEKYAELDPSFAGSRECKLLEDLLEAVEEGDVEAFTDAVKEYDSISKL 263

                        170
                 ....*....|....*
gi 545686629 179 DQWLTTMLLRIKKSI 193
Cdd:cd15832  264 DKWKTTMLLKIKKSI 278
 
Name Accession Description Interval E-value
SNAP pfam14938
Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are ...
 20-193 1.82e-90

Soluble NSF attachment protein, SNAP; The soluble NSF attachment protein (SNAP) proteins are involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus. They act as adaptors between SNARE (integral membrane SNAP receptor) proteins and NSF (N-ethylmaleimide-sensitive factor). They are structurally similar to TPR repeats.


Pssm-ID: 405606 [Multi-domain]  Cd Length: 273  Bit Score: 266.36  E-value: 1.82e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545686629   20 KGRFTIAAKHHITIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIYEQVGANTM 99
Cdd:pfam14938  99 MGRFRRAAKHKKEIAELYEQELGDLEKAIEAYEQAADWYEGEGASALANKCYLKVADLSAELEDYPKAIEIYEKVAKNSL 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545686629  100 DNPLLKYSAKDYFFKAALCHF-IVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSEAYTEAVKEFDSISRL 178
Cdd:pfam14938 179 ENNLLKYSVKEYFLKAGLCHLaAGDLVAAQRALERYEELDPSFADTREYKLLNDLLEAVEEGDVEAFTDAVFEFDQISKL 258

                         170
                  ....*....|....*
gi 545686629  179 DQWLTTMLLRIKKSI 193
Cdd:pfam14938 259 DKWKTTILLKIKNTI 273
SNAP cd15832
Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the ...
 20-193 9.85e-88

Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family; Members of the soluble NSF attachment protein (SNAP) family are involved in intracellular membrane trafficking, including vesicular transport between the endoplasmic reticulum and Golgi apparatus. Higher eukaryotes contain three isoforms of SNAPs: alpha, beta, and gamma. Alpha-SNAP is universally present in eukaryotes and acts as an adaptor protein between SNARE (integral membrane SNAP receptor) and NSF for recruitment to the 20S complex. Beta-SNAP is brain-specific and shares high sequence identity (about 85%) with alpha-SNAP. Gamma-SNAP is weakly related (about 20-25% identity) to the two other isoforms, and is ubiquitous. It may help regulate the activity of the 20S complex. The X-ray structures of vertebrate gamma-SNAP and yeast Sec17, a SNAP family member, show similar all-helical structures consisting of an N-terminal extended twisted sheet of four Tetratricopeptide repeat (TPR)-like helical hairpins and a C-terminal helical bundle.


Pssm-ID: 276937 [Multi-domain]  Cd Length: 278  Bit Score: 259.43  E-value: 9.85e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545686629  20 KGRFTIAAKHHITIAEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIYEQVGANTM 99
Cdd:cd15832  104 MGRFRQAAKHLKEIAELYENELGDLDKAIEAYEQAADYYEGEGANSLANKCYLKVADLAAQLEDYDKAIEIYEQVARSSL 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545686629 100 DNPLLKYSAKDYFFKAALCHF-IVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSEAYTEAVKEFDSISRL 178
Cdd:cd15832  184 ENNLLKYSAKDYFLKAGLCHLaAGDVVAAQRALEKYAELDPSFAGSRECKLLEDLLEAVEEGDVEAFTDAVKEYDSISKL 263

                        170
                 ....*....|....*
gi 545686629 179 DQWLTTMLLRIKKSI 193
Cdd:cd15832  264 DKWKTTMLLKIKKSI 278
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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