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Conserved domains on  [gi|556695383|ref|NP_001273365|]
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nucleoside diphosphate kinase, mitochondrial isoform d [Homo sapiens]

Protein Classification

nucleoside-diphosphate kinase( domain architecture ID 10138292)

nucleoside-diphosphate kinase catalyzes the exchange of phosphate groups between different nucleoside diphosphates

CATH:  3.30.70.141
EC:  2.7.4.6
Gene Ontology:  GO:0006241|GO:0004550|GO:0046872|GO:0005524|GO:0006228|GO:0006183
SCOP:  4001261

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 1-97 4.03e-60

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


:

Pssm-ID: 239876  Cd Length: 130  Bit Score: 180.36  E-value: 4.03e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:cd04413   34 LKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAVKTVRKLMGATNPADAAPGTIRGDFALSIGRNIV 113

                         90
                 ....*....|....*..
gi 556695383  81 HASDSVEGAQREIQLWF 97
Cdd:cd04413  114 HGSDSVESAEREIALWF 130
 
Name Accession Description Interval E-value
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 1-97 4.03e-60

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 180.36  E-value: 4.03e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:cd04413   34 LKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAVKTVRKLMGATNPADAAPGTIRGDFALSIGRNIV 113

                         90
                 ....*....|....*..
gi 556695383  81 HASDSVEGAQREIQLWF 97
Cdd:cd04413  114 HGSDSVESAEREIALWF 130
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 1-102 1.16e-58

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 176.97  E-value: 1.16e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383     1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:smart00562  34 MKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAVKTWRTLMGPTDPREAAPGTIRGDFGLDIGRNAV 113

                           90       100
                   ....*....|....*....|..
gi 556695383    81 HASDSVEGAQREIQLWFQSSEL 102
Cdd:smart00562 114 HGSDSPESAEREIALFFPESEI 135
NDK pfam00334
Nucleoside diphosphate kinase;
1-102 1.52e-57

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 174.21  E-value: 1.52e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383    1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:pfam00334  34 LKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAISKWRELMGATNPAEAAPGTIRGDFAVSIGRNAV 113

                          90       100
                  ....*....|....*....|..
gi 556695383   81 HASDSVEGAQREIQLWFQSSEL 102
Cdd:pfam00334 114 HGSDSPESAEREIALFFPEEEI 135
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 1-105 1.69e-57

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 174.10  E-value: 1.69e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:COG0105   36 LKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGENAVAVVRKLMGATNPAEAAPGTIRGDFALSIGENAV 115

                         90       100
                 ....*....|....*....|....*
gi 556695383  81 HASDSVEGAQREIQLWFQSSELVSW 105
Cdd:COG0105  116 HGSDSPESAEREIALFFSEEEIVSY 140
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 1-105 1.40e-54

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 167.21  E-value: 1.40e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:PTZ00093  36 LKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKNVVKQGRKLLGATNPLESAPGTIRGDFCVDVGRNVI 115

                         90       100
                 ....*....|....*....|....*
gi 556695383  81 HASDSVEGAQREIQLWFQSSELVSW 105
Cdd:PTZ00093 116 HGSDSVESAKREIALWFKPEELVSW 140
 
Name Accession Description Interval E-value
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 1-97 4.03e-60

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 180.36  E-value: 4.03e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:cd04413   34 LKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAVKTVRKLMGATNPADAAPGTIRGDFALSIGRNIV 113

                         90
                 ....*....|....*..
gi 556695383  81 HASDSVEGAQREIQLWF 97
Cdd:cd04413  114 HGSDSVESAEREIALWF 130
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 1-102 1.16e-58

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 176.97  E-value: 1.16e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383     1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:smart00562  34 MKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAVKTWRTLMGPTDPREAAPGTIRGDFGLDIGRNAV 113

                           90       100
                   ....*....|....*....|..
gi 556695383    81 HASDSVEGAQREIQLWFQSSEL 102
Cdd:smart00562 114 HGSDSPESAEREIALFFPESEI 135
NDK pfam00334
Nucleoside diphosphate kinase;
1-102 1.52e-57

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 174.21  E-value: 1.52e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383    1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:pfam00334  34 LKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAISKWRELMGATNPAEAAPGTIRGDFAVSIGRNAV 113

                          90       100
                  ....*....|....*....|..
gi 556695383   81 HASDSVEGAQREIQLWFQSSEL 102
Cdd:pfam00334 114 HGSDSPESAEREIALFFPEEEI 135
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 1-105 1.69e-57

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 174.10  E-value: 1.69e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:COG0105   36 LKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGENAVAVVRKLMGATNPAEAAPGTIRGDFALSIGENAV 115

                         90       100
                 ....*....|....*....|....*
gi 556695383  81 HASDSVEGAQREIQLWFQSSELVSW 105
Cdd:COG0105  116 HGSDSPESAEREIALFFSEEEIVSY 140
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 1-105 1.40e-54

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 167.21  E-value: 1.40e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:PTZ00093  36 LKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKNVVKQGRKLLGATNPLESAPGTIRGDFCVDVGRNVI 115

                         90       100
                 ....*....|....*....|....*
gi 556695383  81 HASDSVEGAQREIQLWFQSSELVSW 105
Cdd:PTZ00093 116 HGSDSVESAKREIALWFKPEELVSW 140
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 1-100 5.75e-53

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 162.58  E-value: 5.75e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:PRK00668  35 LKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAIAKVRELMGATNPAEAAPGTIRGDFALSIGENVV 114

                         90       100
                 ....*....|....*....|
gi 556695383  81 HASDSVEGAQREIQLWFQSS 100
Cdd:PRK00668 115 HGSDSPESAAREIALFFSEE 134
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 1-97 2.06e-37

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 123.23  E-value: 2.06e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEA---APGTIRGDFSVHISR 77
Cdd:cd00595   34 MKELHLTEEQAEEFYVEHKGRPFFPDLVQFMSSGPVVAMILEKDNAVGEWREMLGPTNPEIArhlAPGSLRADFGTDVLR 113

                         90       100
                 ....*....|....*....|
gi 556695383  78 NVIHASDSVEGAQREIQLWF 97
Cdd:cd00595  114 NAVHGSDSVESAAREIAFFF 133
PLN02619 PLN02619
nucleoside-diphosphate kinase
 14-106 9.17e-37

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 124.58  E-value: 9.17e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383  14 HYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQREI 93
Cdd:PLN02619 135 HYHDLKERPFFNGLCDFLSSGPVVAMVWEGEGVIKYGRKLIGATDPQKSEPGTIRGDLAVVVGRNIIHGSDGPETAKDEI 214

                         90
                 ....*....|...
gi 556695383  94 QLWFQSSELVSWA 106
Cdd:PLN02619 215 NLWFKPEELVSYT 227
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 1-99 4.61e-36

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 119.93  E-value: 4.61e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:PRK14540  36 MKMLKLTREMAEEYYEEHKGKEFYERLINFMTSGRIVAMVIEGENAISTVRKMIGKTNPAEAEPGTIRGDFGLYTPANII 115

                         90
                 ....*....|....*....
gi 556695383  81 HASDSVEGAQREIQLWFQS 99
Cdd:PRK14540 116 HASDSKESAEREIKLFFGE 134
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 26-103 3.75e-25

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 93.34  E-value: 3.75e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383  26 ALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSV----------HISRNVIHASDSVEGAQREIQL 95
Cdd:PRK14544  95 SLVKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKAPPGTIRGDYSIdspdlaaeegRVVYNLVHASDSPEEAEREIKF 174


                 ....*...
gi 556695383  96 WFQSSELV 103
Cdd:PRK14544 175 WFREEEIL 182
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 1-103 3.32e-24

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 89.62  E-value: 3.32e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:PRK14541  35 MKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENAVADFRTLIGATDPAEAAEGTVRKLYADSKGENIV 114

                         90       100
                 ....*....|....*....|...
gi 556695383  81 HASDSVEGAQREIQLWFQSSELV 103
Cdd:PRK14541 115 HGSDSAENAAIEAGFFFSAEEVV 137
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 12-111 2.75e-21

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 83.34  E-value: 2.75e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383  12 AEHYQdlrrKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAA---PGTIRGDFSVHISRNVIHASDSVEG 88
Cdd:PLN02931  78 AEHSS----RSFFPSLVKYMTSGPVLVMVLEKENAVSDWRTLIGPTDARKAKishPNSIRAMCGLDSEKNCVHGSDSPES 153

                         90       100
                 ....*....|....*....|...
gi 556695383  89 AQREIQLWFQssELVSWADGGQH 111
Cdd:PLN02931 154 AEREISFFFG--DVSSGDVASQH 174
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 1-102 2.05e-20

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 80.10  E-value: 2.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:PRK14542  35 LKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNAVLHWREVIGATDPKEAAAGTIRALYAESKEANAV 114

                         90       100
                 ....*....|....*....|..
gi 556695383  81 HASDSVEGAQREIQLWFQSSEL 102
Cdd:PRK14542 115 HGSDSDANAALEISFFFKGNEL 136
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 1-101 5.55e-20

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 78.79  E-value: 5.55e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVI 80
Cdd:PRK14545  37 MKLTQLTVADAETFYAVHAERPFYGELVEFMSRGPIVAAILEKENAVEDFRTLIGATNPADAAEGTIRKKYAKSIGENAV 116

                         90       100
                 ....*....|....*....|.
gi 556695383  81 HASDSVEGAQREIQLWFQSSE 101
Cdd:PRK14545 117 HGSDSDENAQIEGAFHFAGRE 137
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 2-97 6.01e-20

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 78.64  E-value: 6.01e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   2 KMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEA---APGTIRGDFSVHISRN 78
Cdd:cd04415   33 KMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISEWRKLLGPTNSSVArsdAPNSIRALFGTDGTRN 112

                         90
                 ....*....|....*....
gi 556695383  79 VIHASDSVEGAQREIQLWF 97
Cdd:cd04415  113 AAHGSDSVASAARELEFFF 131
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 2-105 1.34e-19

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 78.78  E-value: 1.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   2 KMLQAPESVLAEHY--QD--LRRKPF-YPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHIS 76
Cdd:PRK14543  40 KMLLVDRSMAEKHYlyDDiaVRHGEAvWKSLIKFISSSPVFVFVVEGVESVEVVRKFCGSTEPKLAIPGTIRGDFSYHSF 119

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 556695383  77 R----------NVIHASDSVEGAQREIQLWFQSSELVSW 105
Cdd:PRK14543 120 NyanekgfsvyNVIHASANEDDALREIPIWFKDNEILTY 158
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 8-97 1.53e-19

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 77.82  E-value: 1.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   8 ESVLAEHyqdlRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEA---APGTIRGDFSVHISRNVIHASD 84
Cdd:cd04414   46 ERFYAEH----KGKFFYDRLVSFMTSGPSWALILAHENAIKTWRALMGPTKVFRArasAPDSIRGLYGLTDTRNATHGSD 121

                         90
                 ....*....|...
gi 556695383  85 SVEGAQREIQLWF 97
Cdd:cd04414  122 SPASAQREIALFF 134
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 1-97 3.24e-18

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 74.01  E-value: 3.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVlAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEA---APGTIRGDFSVHISR 77
Cdd:cd04418   33 RKLQLSPEQC-SDFYAEHYGKMFFPHLVAYMSSGPIVAMVLARHNAISYWKELLGPTNSLKAketHPDSLRAIYGTDDLR 111

                         90       100
                 ....*....|....*....|
gi 556695383  78 NVIHASDSVEGAQREIQLWF 97
Cdd:cd04418  112 NAVHGSDSFSSAEREIRFMF 131
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 1-97 3.91e-17

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 71.47  E-value: 3.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383   1 MKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEA---APGTIRGDFSVHISR 77
Cdd:cd04416   33 QKEMVLTEEQAREFYKEHEEEDYFEDLVEFMTSGPSLILVLSKENAVEEWRELMGPTDPEEAkeeKPDSLRAQFARDHLS 112

                         90       100
                 ....*....|....*....|
gi 556695383  78 NVIHASDSVEGAQREIQLWF 97
Cdd:cd04416  113 NAVHGSSSAEEAEKEIDFFF 132
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 13-97 8.23e-17

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 70.74  E-value: 8.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556695383  13 EHYQDLrrKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHTDSAEA---APGTIRGDFSVHISRNVIHASDSVEGA 89
Cdd:cd04412   49 EVYKGV--VPELPAMVDELTSGPCIALEIAGENAVKTFREFCGPFDPEIAkqlRPNTLRARYGKDKVQNAVHCTDLPEDG 126


                 ....*...
gi 556695383  90 QREIQLWF 97
Cdd:cd04412  127 PLELKFFF 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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