Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878669  845 LLNPVTSRQFQRFVALKGDLLENGLLFWQEVQKYKDLCHSHCDESVIQKKITTIINCFINSSIPPALQIDIPVEQAQKII 924
Cdd:cd08725     1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 557878669  925 EHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDENIMS 967
Cdd:cd08725    81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKILT 123

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878669  845 LLNPVTSRQFQRFVALKGDLLENGLLFWQEVQKYKDLCHSHCDESVIQKKITTIINCFINSSIPPALQIDIPVEQAQKII 924
Cdd:cd08725     1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 557878669  925 EHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDENIMS 967
Cdd:cd08725    81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKILT 123

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878669    841 FRKALLNPVTSRQFQRFvaLKGDLLENGLLFWQEVQKYKDLchshCDESVIQKKITTIINCFINSSIPPALQIDI-PVEQ 919
Cdd:smart00315    2 LESLLSDPIGRLLFREF--LESEFSEENLEFWLAVEEFKKA----EDDEERIAKAREIYDKFLSPNAPKEVNLDSdLREK 75

                            90       100       110
                    ....*....|....*....|....*....|....*..
gi 557878669    920 AQKIIEHRkELGPYVFREAQMTIFGVL-FKFWPQFCE 955
Cdd:smart00315   76 IEENLESE-EPPPDLFDEAQREVYELLeKDSFPRFLE 111

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878669    671 KFSDLLNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYIKnkylnkkyFFGPNSPASLYQQNQV 750
Cdd:smart00315    1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAEDDEERIAKAREIYDK--------FLSPNAPKEVNLDSDL 72

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*.
gi 557878669    751 M-HLSGGwgkILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQF 795
Cdd:smart00315   73 ReKIEEN---LESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYY 115

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878669  845 LLNPVTSRQFQRFVALKGDLLENGLLFWQEVQKYKDLCHSHCDESVIQKKITTIINCFINSSIPPALQIDIPVEQAQKII 924
Cdd:cd08725     1 LLNPVTSEQFQRFVSLKGEELENDLLFWLEVQKYKDLCHSHSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRIL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 557878669  925 EHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDENIMS 967
Cdd:cd08725    81 EHRRELGPYIFREAQLTVFRVLFKYWAGFCEFRKNLQPEKILT 123

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878669  676 LNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRnQRKAKSIYIKNKYLNKKYFFGPNSPASLyqQNQVMHlsg 755
Cdd:cd07440     1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSDE-ELKSKAKEIYDKYISKDAPKEINIPESI--REEIEE--- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 557878669  756 gwgKILHEQLDAPVLVEIQKHVQNRLENVWLPLFLASEQF 795
Cdd:cd07440    75 ---NLEEPYPDPDCFDEAQEHILNLLEKDSYPRFLKSDLY 111

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878669  495 FFFTKFCEHSGNKlwkNSVYFWFDLQAYHQLFYQETlqpfKVCKQAQYLFATYVAPSATLDIGLQQEKKKEIYMKIQPP- 573
Cdd:cd07440     8 EYFRQFLKSEHCE---ENLEFWLAVEKFKKTTSSDE----ELKSKAKEIYDKYISKDAPKEINIPESIREEIEENLEEPy 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 557878669  574 -FEDLFDTAEEYILLL-LLEPWTKMVKSDQ 601
Cdd:cd07440    81 pDPDCFDEAQEHILNLlEKDSYPRFLKSDL 110

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878669  845 LLNPVTSRQFQRFVALKGDllENGLLFWQEVQKYKDLCHShcdESVIQKKITTIINCFINSSIPPALQIDipvEQAQKII 924
Cdd:cd07440     1 LRDPYGLEYFRQFLKSEHC--EENLEFWLAVEKFKKTTSS---DEELKSKAKEIYDKYISKDAPKEINIP---ESIREEI 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 557878669  925 EHR---KELGPYVFREAQMTIFGVLFK-FWPQFCEFRKNL 960
Cdd:cd07440    73 EENleePYPDPDCFDEAQEHILNLLEKdSYPRFLKSDLYL 112

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878669  676 LNNKLEFEHFRQFLETHSSSMDLMCWTDIEQFRRITYRDRNQRKAKSIYiknkylnKKYFFGPNSPASLYQQNQVMhlsg 755
Cdd:cd08728     1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIV-------KRYFHGQDPPGVLLQCEAII---- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878669  756 gwgkILHEQLDAPV----LVEIQKHVQNRLENVWLPLFlaSEQFAARQkIKVQMKDIAEELLLQKAEKKIGVWKPVESKW 831
Cdd:cd08728    70 ----IREIAMMKVVttsmLLSIQHLVSKSLEERWFKKY--QDTFPDCP-HEVEPDEEIKVPLKPTKLKAPHVISSQKRAW 142

                         170       180       190
                  ....*....|....*....|....*....|
gi 557878669  832 ---ISSSCKIIAFRKALLNPVTSRQFQRFV 858
Cdd:cd08728   143 eifISFIRSFIKFRRFMVNREIRQEFEDYL 172

Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins; The RGS (Regulator of G-protein Signaling) domain is an essential part of the R7 (Neuronal RGS) protein subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The R7 subfamily includes RGS6, RGS7, RGS9, and RGS11, all of which, in humans, are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes. In addition, R7 proteins were found to bind many other proteins outside of the G protein signaling pathways including: m-opioid receptor, beta-arrestin, alpha-actinin-2, NMDAR, polycystin, spinophilin, guanylyl cyclase, among others.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878669  839 IAFRKALLNPVTSRQFQRFvaLKGDLLENGLLFWQEVQKYKdlchsHCDESVIQKKITTIINCFINSSIPPALQIDIPV- 917
Cdd:cd08705     7 FSFSELLKDPVGREQFLKF--LEKEFSGENLRFWEACQDLK-----YGPQSQVPEKVQEIYQEFLAPGAPSWINIDSKTm 79

                          90       100
                  ....*....|....*....|....*.
gi 557878669  918 EQAQKIIEHRkelGPYVFREAQMTIF 943
Cdd:cd08705    80 EITLKNLKDP---HRYTFDAAQEHIY 102

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557878669  502 EHSgnklwKNSVYFWFDLQAYHQLFYQetlqpFKVCKQAQYLFATYVAPSATLDIGLQQEKKKEIYMKIQPPFEDLFDTA 581
Cdd:cd08716    21 EHS-----DENIEFWLACETYKKIASQ-----RKRISMARKLFASYIQPQAPREINIDSPTRKAIIRNIQEPTQSCFDEA 90

                  ....
gi 557878669  582 EEYI 585
Cdd:cd08716    91 QRIV 94