|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08315 |
PRK08315 |
AMP-binding domain protein; Validated |
82-640 |
0e+00 |
|
AMP-binding domain protein; Validated
Pssm-ID: 236236 [Multi-domain] Cd Length: 559 Bit Score: 783.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 82 GLSYVQGCTKKHLNSKTVGQCLETTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYA 161
Cdd:PRK08315 1 GLSYVRGPTDVPLLEQTIGQLLDRTAARYPDREALVYRDQGLRWTYREFNEEVDALAKGLLALGIEKGDRVGIWAPNVPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 162 WVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVENAQPGALKSQRLPDLTTV 241
Cdd:PRK08315 81 WVLTQFATAKIGAILVTINPAYRLSELEYALNQSGCKALIAADGFKDSDYVAMLYELAPELATCEPGQLQSARLPELRRV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 242 ISVDA-PLPGTLLLDEVVAAGSTRqHLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhe 320
Cdd:PRK08315 161 IFLGDeKHPGMLNFDELLALGRAV-DDAELAARQATLDPDDPINIQYTSGTTGFPKGATLTHRNILNNGYFIGEAMKL-- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 321 kTPEQlRMILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDIS 400
Cdd:PRK08315 238 -TEED-RLCIPVPLYHCFGMVLGNLACVTHGATMVYPGEGFDPLATLAAVEEERCTALYGVPTMFIAELDHPDFARFDLS 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 401 TMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKL 480
Cdd:PRK08315 316 SLRTGIMAGSPCPIEVMKRVIDKMHMSEVTIAYGMTETSPVSTQTRTDDPLEKRVTTVGRALPHLEVKIVDPETGETVPR 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 481 NTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKV 560
Cdd:PRK08315 396 GEQGELCTRGYSVMKGYWNDPEKTAEAIDADGWMHTGDLAVMDEEGYVNIVGRIKDMIIRGGENIYPREIEEFLYTHPKI 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 561 QEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMERHLNL 640
Cdd:PRK08315 476 QDVQVVGVPDEKYGEEVCAWIILRPGATLTEEDVRDFCRGKIAHYKIPRYIRFVDEFPMTVTGKIQKFKMREMMIEELGL 555
|
|
| PRK12583 |
PRK12583 |
acyl-CoA synthetase; Provisional |
82-634 |
0e+00 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237145 [Multi-domain] Cd Length: 558 Bit Score: 659.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 82 GLSYVQGCTKKHLNSKTVGQCLETTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYA 161
Cdd:PRK12583 3 QPSYYQGGGDKPLLTQTIGDAFDATVARFPDREALVVRHQALRYTWRQLADAVDRLARGLLALGVQPGDRVGIWAPNCAE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 162 WVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVENAQPGALKSQRLPDLTTV 241
Cdd:PRK12583 83 WLLTQFATARIGAILVNINPAYRASELEYALGQSGVRWVICADAFKTSDYHAMLQELLPGLAEGQPGALACERLPELRGV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 242 ISVD-APLPGTLLLDEVVAAGS--TRQHLDQLQynqQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKL 318
Cdd:PRK12583 163 VSLApAPPPGFLAWHELQARGEtvSREALAERQ---ASLDRDDPINIQYTSGTTGFPKGATLSHHNILNNGYFVAESLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 319 HEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYD 398
Cdd:PRK12583 240 TEHD----RLCVPVPLYHCFGMVLANLGCMTVGACLVYPNEAFDPLATLQAVEEERCTALYGVPTMFIAELDHPQRGNFD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 399 ISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLA 478
Cdd:PRK12583 316 LSSLRTGIMAGAPCPIEVMRRVMDEMHMAEVQIAYGMTETSPVSLQTTAADDLERRVETVGRTQPHLEVKVVDPDGATVP 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 479 KLNTpGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHP 558
Cdd:PRK12583 396 RGEI-GELCTRGYSVMKGYWNNPEATAESIDEDGWMHTGDLATMDEQGYVRIVGRSKDMIIRGGENIYPREIEEFLFTHP 474
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572872742 559 KVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQM 634
Cdd:PRK12583 475 AVADVQVFGVPDEKYGEEIVAWVRLHPGHAASEEELREFCKARIAHFKVPRYFRFVDEFPMTVTGKVQKFRMREIS 550
|
|
| FACL_like_2 |
cd05917 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
279-631 |
0e+00 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341241 [Multi-domain] Cd Length: 349 Bit Score: 646.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 279 CHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhektPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILAS 358
Cdd:cd05917 1 PDDVINIQFTSGTTGSPKGATLTHHNIVNNGYFIGERLGL----TEQDRLCIPVPLFHCFGSVLGVLACLTHGATMVFPS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 359 PIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTEN 438
Cdd:cd05917 77 PSFDPLAVLEAIEKEKCTALHGVPTMFIAELEHPDFDKFDLSSLRTGIMAGAPCPPELMKRVIEVMNMKDVTIAYGMTET 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 439 SPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGD 518
Cdd:cd05917 157 SPVSTQTRTDDSIEKRVNTVGRIMPHTEAKIVDPEGGIVPPVGVPGELCIRGYSVMKGYWNDPEKTAEAIDGDGWLHTGD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 519 VATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFC 598
Cdd:cd05917 237 LAVMDEDGYCRIVGRIKDMIIRGGENIYPREIEEFLHTHPKVSDVQVVGVPDERYGEEVCAWIRLKEGAELTEEDIKAYC 316
|
330 340 350
....*....|....*....|....*....|...
gi 572872742 599 KGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05917 317 KGKIAHYKVPRYVFFVDEFPLTVSGKIQKFKLR 349
|
|
| MenE/FadK |
COG0318 |
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ... |
99-637 |
2.17e-167 |
|
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 440087 [Multi-domain] Cd Length: 452 Bit Score: 485.85 E-value: 2.17e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 99 VGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVS 178
Cdd:COG0318 1 LADLLRRAAARHPDRPALV--FGGRRLTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAGAVVVP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 179 VNPAYQAMELEYVLKKVGCKALVFpkqfktqqyynvlkqicpevenaqpgalksqrlpdlttvisvdaplpgtllldevv 258
Cdd:COG0318 79 LNPRLTAEELAYILEDSGARALVT-------------------------------------------------------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 259 aagstrqhldqlqynqqflschdpINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCL 338
Cdd:COG0318 103 ------------------------ALILYTSGTTGRPKGVMLTHRNLLANAAAIAAALGLTPGD----VVLVALPLFHVF 154
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 339 GSVAGTMMCLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIR 418
Cdd:COG0318 155 GLTVGLLAPLLAGATLVLL-PRFDPERVLELIERERVTVLFGVPTMLARLLRHPEFARYDLSSLRLVVSGGAPLPPELLE 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 419 AIINKINMKdLVVAYGTTENSPVTFAHfPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYW 498
Cdd:COG0318 234 RFEERFGVR-IVEGYGLTETSPVVTVN-PEDPGERRPGSVGRPLPGVEVRIVD-EDGRELPPGEVGEIVVRGPNVMKGYW 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 499 GEPQKTEEAVDqDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEIC 578
Cdd:COG0318 311 NDPEATAEAFR-DGWLRTGDLGRLDEDGYLYIVGRKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVVGVPDEKWGERVV 389
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 572872742 579 ACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMERH 637
Cdd:COG0318 390 AFVVLRPGAELDAEELRAFLRERLARYKVPRRVEFVDELPRTASGKIDRRALRERYAAG 448
|
|
| PRK07656 |
PRK07656 |
long-chain-fatty-acid--CoA ligase; Validated |
98-633 |
2.62e-140 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236072 [Multi-domain] Cd Length: 513 Bit Score: 418.54 E-value: 2.62e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 98 TVGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILV 177
Cdd:PRK07656 6 TLPELLARAARRFGDKEAYV--FGDQRLTYAELNARVRRAAAALAALGIGKGDRVAIWAPNSPHWVIAALGALKAGAVVV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 178 SVNPAYQAMELEYVLKKVGCKALVFPKQFktqqyynvlkqiCPEVENAqpgalkSQRLPDLTTVISV-----DAPLPGTL 252
Cdd:PRK07656 84 PLNTRYTADEAAYILARGDAKALFVLGLF------------LGVDYSA------TTRLPALEHVVICeteedDPHTEKMK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 253 LLDEVVAAGSTRQHLDQLQYNqqflschDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPN 332
Cdd:PRK07656 146 TFTDFLAAGDPAERAPEVDPD-------DVADILFTSGTTGRPKGAMLTHRQLLSNAADWAEYLGLTEGD----RYLAAN 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 333 PLYHCLGSVAGTMMCLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPA 412
Cdd:PRK07656 215 PFFHVFGYKAGVNAPLMRGATILPL-PVFDPDEVFRLIETERITVLPGPPTMYNSLLQHPDRSAEDLSSLRLAVTGAASM 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 413 PPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYC 492
Cdd:PRK07656 294 PVALLERFESELGVDIVLTGYGLSEASGVTTFNRLDDDRKTVAGTIGTAIAGVENKIVN-ELGEEVPVGEVGELLVRGPN 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 493 VMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDR 572
Cdd:PRK07656 373 VMKGYYDDPEATAAAIDADGWLHTGDLGRLDEEGYLYIVDRKKDMFIVGGFNVYPAEVEEVLYEHPAVAEAAVIGVPDER 452
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572872742 573 MGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK07656 453 LGEVGKAYVVLKPGAELTEEELIAYCREHLAKYKVPRSIEFLDELPKNATGKVLKRALREK 513
|
|
| PRK06187 |
PRK06187 |
long-chain-fatty-acid--CoA ligase; Validated |
98-633 |
1.62e-127 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235730 [Multi-domain] Cd Length: 521 Bit Score: 386.08 E-value: 1.62e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 98 TVGQCLETTAQRVPEREALVVlhEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILV 177
Cdd:PRK06187 7 TIGRILRHGARKHPDKEAVYF--DGRRTTYAELDERVNRLANALRALGVKKGDRVAVFDWNSHEYLEAYFAVPKIGAVLH 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 178 SVNPAYQAMELEYVLKKVGCKALVFPKQFKtqqyynvlkqicPEVENAQPgalksqRLPDLTTVISV-DAPLPGT----L 252
Cdd:PRK06187 85 PINIRLKPEEIAYILNDAEDRVVLVDSEFV------------PLLAAILP------QLPTVRTVIVEgDGPAAPLapevG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 253 LLDEVVAAGSTR---QHLDQlqynqqflscHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMI 329
Cdd:PRK06187 147 EYEELLAAASDTfdfPDIDE----------NDAAAMLYTSGTTGHPKGVVLSHRNLFLHSLAVCAWLKLSRDD----VYL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 330 LPNPLYHCLGSVAGtMMCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAG 409
Cdd:PRK06187 213 VIVPMFHVHAWGLP-YLALMAGAKQVIPRR-FDPENLLDLIETERVTFFFAVPTIWQMLLKAPRAYFVDFSSLRLVIYGG 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 410 SPAPPELIRAIINKINMkDLVVAYGTTENSP-VTFAHFPEDTVEQ--KAESVGRIMPHTEARIMNMEAGTLAK-LNTPGE 485
Cdd:PRK06187 291 AALPPALLREFKEKFGI-DLVQGYGMTETSPvVSVLPPEDQLPGQwtKRRSAGRPLPGVEARIVDDDGDELPPdGGEVGE 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 486 LCIRGYCVMLGYWGEPQKTEEAVDQDkWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQV 565
Cdd:PRK06187 370 IIVRGPWLMQGYWNRPEATAETIDGG-WLHTGDVGYIDEDGYLYITDRIKDVIISGGENIYPRELEDALYGHPAVAEVAV 448
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 572872742 566 VGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK06187 449 IGVPDEKWGERPVAVVVLKPGATLDAKELRAFLRGRLAKFKLPKRIAFVDELPRTSVGKILKRVLREQ 516
|
|
| FC-FACS_FadD_like |
cd05936 |
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ... |
103-631 |
4.18e-125 |
|
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341259 [Multi-domain] Cd Length: 468 Bit Score: 378.06 E-value: 4.18e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVVLheDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:cd05936 5 LEEAARRFPDKTALIFM--GRKLTYRELDALAEAFAAGLQNLGVQPGDRVALMLPNCPQFPIAYFGALKAGAVVVPLNPL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKALVFPKQFKTqqyynvlkqicpevenaqpgALKSQRLPDLTTVISVDAplpgtllldevVAAgs 262
Cdd:cd05936 83 YTPRELEHILNDSGAKALIVAVSFTD--------------------LLAAGAPLGERVALTPED-----------VAV-- 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 263 trqhldqlqynqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKlhEKTPEQLRMILPNPLYHCLGSVA 342
Cdd:cd05936 130 ----------------------LQYTSGTTGVPKGAMLTHRNLVANALQIKAWLE--DLLEGDDVVLAALPLFHVFGLTV 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 343 GTMMCLMYGATLILaSPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDIST---MCGGviaGSPAPPELIRA 419
Cdd:cd05936 186 ALLLPLALGATIVL-IPRFRPIGVLKEIRKHRVTIFPGVPTMYIALLNAPEFKKRDFSSlrlCISG---GAPLPVEVAER 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 420 IiNKINMKDLVVAYGTTENSPVTFAHFPEDtvEQKAESVGRIMPHTEARIMNMEaGTLAKLNTPGELCIRGYCVMLGYWG 499
Cdd:cd05936 262 F-EELTGVPIVEGYGLTETSPVVAVNPLDG--PRKPGSIGIPLPGTEVKIVDDD-GEELPPGEVGELWVRGPQVMKGYWN 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 500 EPQKTEEAVDqDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICA 579
Cdd:cd05936 338 RPEETAEAFV-DGWLRTGDIGYMDEDGYFFIVDRKKDMIIVGGFNVYPREVEEVLYEHPAVAEAAVVGVPDPYSGEAVKA 416
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 572872742 580 CIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05936 417 FVVLKEGASLTEEEIIAFCREQLAGYKVPRQVEFRDELPKSAVGKILRRELR 468
|
|
| FACL_FadD13-like |
cd17631 |
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ... |
103-627 |
2.96e-120 |
|
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.
Pssm-ID: 341286 [Multi-domain] Cd Length: 435 Bit Score: 364.24 E-value: 2.96e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:cd17631 1 LRRRARRHPDRTALV--FGGRSLTYAELDERVNRLAHALRALGVAKGDRVAVLSKNSPEFLELLFAAARLGAVFVPLNFR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKALVfpkqfktqqyynvlkqicpevenaqpgalksqrlpdlttvisvdaplpgtllldevvaags 262
Cdd:cd17631 79 LTPPEVAYILADSGAKVLF------------------------------------------------------------- 97
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 263 trqhldqlqynqqflscHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLGSVA 342
Cdd:cd17631 98 -----------------DDLALLMYTSGTTGRPKGAMLTHRNLLWNAVNALAALDLGPDD----VLLVVAPLFHIGGLGV 156
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 343 GTMMCLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIIN 422
Cdd:cd17631 157 FTLPTLLRGGTVVIL-RKFDPETVLDLIERHRVTSFFLVPTMIQALLQHPRFATTDLSSLRAVIYGGAPMPERLLRALQA 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 423 KInmKDLVVAYGTTENSPVTFAHFPEDTVEqKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQ 502
Cdd:cd17631 236 RG--VKFVQGYGMTETSPGVTFLSPEDHRR-KLGSAGRPVFFVEVRIVD-PDGREVPPGEVGEIVVRGPHVMAGYWNRPE 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 503 KTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIR 582
Cdd:cd17631 312 ATAAAF-RDGWFHTGDLGRLDEDGYLYIVDRKKDMIISGGENVYPAEVEDVLYEHPAVAEVAVIGVPDEKWGEAVVAVVV 390
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 572872742 583 LKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 627
Cdd:cd17631 391 PRPGAELDEDELIAHCRERLARYKIPKSVEFVDALPRNATGKILK 435
|
|
| AFD_class_I |
cd04433 |
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ... |
281-626 |
1.02e-114 |
|
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.
Pssm-ID: 341228 [Multi-domain] Cd Length: 336 Bit Score: 346.58 E-value: 1.02e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 281 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHcLGSVAGTMMCLMYGATLILAsPI 360
Cdd:cd04433 1 DPALILYTSGTTGKPKGVVLSHRNLLAAAAALAASGGLTEGD----VFLSTLPLFH-IGGLFGLLGALLAGGTVVLL-PK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 361 FNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSP 440
Cdd:cd04433 75 FDPEAALELIEREKVTILLGVPTLLARLLKAPESAGYDLSSLRALVSGGAPLPPELLERFEEAPGIK-LVNGYGLTETGG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 441 VTFAHFPEDtVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEaVDQDKWYWTGDVA 520
Cdd:cd04433 154 TVATGPPDD-DARKPGSVGRPVPGVEVRIVD-PDGGELPPGEIGELVVRGPSVMKGYWNNPEATAA-VDEDGWYRTGDLG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 521 TMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKG 600
Cdd:cd04433 231 RLDEDGYLYIVGRLKDMIKSGGENVYPAEVEAVLLGHPGVAEAAVVGVPDPEWGERVVAVVVLRPGADLDAEELRAHVRE 310
|
330 340
....*....|....*....|....*.
gi 572872742 601 KISHFKIPKYIVFVTNYPLTISGKIQ 626
Cdd:cd04433 311 RLAPYKVPRRVVFVDALPRTASGKID 336
|
|
| AMP-binding |
pfam00501 |
AMP-binding enzyme; |
103-541 |
1.55e-112 |
|
AMP-binding enzyme;
Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 343.91 E-value: 1.55e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVVlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:pfam00501 1 LERQAARTPDKTALEV-GEGRRLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAGAVYVPLNPR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKALVFPKQFKtqqyynvLKQICPevenaqpgALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAgs 262
Cdd:pfam00501 80 LPAEELAYILEDSGAKVLITDDALK-------LEELLE--------ALGKLEVVKLVLVLDRDPVLKEEPLPEEAKPA-- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 263 trqhlDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMILPNPLYHCLGSVA 342
Cdd:pfam00501 143 -----DVPPPPPPPPDPDDLAYIIYTSGTTGKPKGVMLTHRNLVANVLSIKRVRPRGFGLGPDDRVLSTLPLFHDFGLSL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 343 GTMMCLMYGATLILASPI--FNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAI 420
Cdd:pfam00501 218 GLLGPLLAGATVVLPPGFpaLDPAALLELIERYKVTVLYGVPTLLNMLLEAGAPKRALLSSLRLVLSGGAPLPPELARRF 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 421 iNKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGE 500
Cdd:pfam00501 298 -RELFGGALVNGYGLTETTGVVTTPLPLDEDLRSLGSVGRPLPGTEVKIVDDETGEPVPPGEPGELCVRGPGVMKGYLND 376
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 572872742 501 PQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRG 541
Cdd:pfam00501 377 PELTAEAFDEDGWYRTGDLGRRDEDGYLEIVGRKKDQIKLG 417
|
|
| PRK08316 |
PRK08316 |
acyl-CoA synthetase; Validated |
95-636 |
5.54e-107 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 181381 [Multi-domain] Cd Length: 523 Bit Score: 333.05 E-value: 5.54e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 95 NSKTVGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGI 174
Cdd:PRK08316 9 RRQTIGDILRRSARRYPDKTALV--FGDRSWTYAELDAAVNRVAAALLDLGLKKGDRVAALGHNSDAYALLWLACARAGA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 175 ILVSVNPAYQAMELEYVLKKVGCKALVFPKQFktqqyynvlkqicpeVENAQPGALKSQRLPDLTTVISVDAPLPGTLL- 253
Cdd:PRK08316 87 VHVPVNFMLTGEELAYILDHSGARAFLVDPAL---------------APTAEAALALLPVDTLILSLVLGGREAPGGWLd 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 254 LDEVVAAGSTRQHLDqlqynqqFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNN--SNILGERLKLHEktpeqlRMILP 331
Cdd:PRK08316 152 FADWAEAGSVAEPDV-------ELADDDLAQILYTSGTESLPKGAMLTHRALIAEyvSCIVAGDMSADD------IPLHA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 332 NPLYHCLGSVAGTMMCLMYGAT-LILASPifNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGS 410
Cdd:PRK08316 219 LPLYHCAQLDVFLGPYLYVGATnVILDAP--DPELILRTIEAERITSFFAPPTVWISLLRHPDFDTRDLSSLRKGYYGAS 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 411 PAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEqKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRG 490
Cdd:PRK08316 297 IMPVEVLKELRERLPGLRFYNCYGQTEIAPLATVLGPEEHLR-RPGSAGRPVLNVETRVVD-DDGNDVAPGEVGEIVHRS 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 491 YCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKD 570
Cdd:PRK08316 375 PQLMLGYWDDPEKTAEAF-RGGWFHSGDLGVMDEEGYITVVDRKKDMIKTGGENVASREVEEALYTHPAVAEVAVIGLPD 453
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572872742 571 DRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMER 636
Cdd:PRK08316 454 PKWIEAVTAVVVPKAGATVTEDELIAHCRARLAGFKVPKRVIFVDELPRNPSGKILKRELRERYAG 519
|
|
| Firefly_Luc_like |
cd05911 |
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ... |
120-626 |
3.02e-102 |
|
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.
Pssm-ID: 341237 [Multi-domain] Cd Length: 486 Bit Score: 319.54 E-value: 3.02e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 120 HEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKA 199
Cdd:cd05911 6 DTGKELTYAQLRTLSRRLAAGLRKLGLKKGDVVGIISPNSTYYPPVFLGCLFAGGIFSAANPIYTADELAHQLKISKPKV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 200 LvfpkqFKTQQYYNVLKQICpevenaqpgalksQRLPDLTTVISVDAPLPGTLLLDEVVAAGSTRQhlDQLQYNQQFLSC 279
Cdd:cd05911 86 I-----FTDPDGLEKVKEAA-------------KELGPKDKIIVLDDKPDGVLSIEDLLSPTLGEE--DEDLPPPLKDGK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 280 HDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEqlRMILPNPLYHCLGsVAGTMMCLMYGATLILaSP 359
Cdd:cd05911 146 DDTAAILYSSGTTGLPKGVCLSHRNLIANLSQVQTFLYGNDGSND--VILGFLPLYHIYG-LFTTLASLLNGATVII-MP 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 360 IFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENS 439
Cdd:cd05911 222 KFDSELFLDLIEKYKITFLYLVPPIAAALAKSPLLDKYDLSSLRVILSGGAPLSKELQELLAKRFPNATIKQGYGMTETG 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 440 PVTFaHFPEDTVeqKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDV 519
Cdd:cd05911 302 GILT-VNPDGDD--KPGSVGRLLPNVEAKIVDDDGKDSLGPNEPGEICVRGPQVMKGYYNNPEATKETFDEDGWLHTGDI 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 520 ATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCK 599
Cdd:cd05911 379 GYFDEDGYLYIVDRKKELIKYKGFQVAPAELEAVLLEHPGVADAAVIGIPDEVSGELPRAYVVRKPGEKLTEKEVKDYVA 458
|
490 500
....*....|....*....|....*...
gi 572872742 600 GKISHFK-IPKYIVFVTNYPLTISGKIQ 626
Cdd:cd05911 459 KKVASYKqLRGGVVFVDEIPKSASGKIL 486
|
|
| PRK13295 |
PRK13295 |
cyclohexanecarboxylate-CoA ligase; Reviewed |
71-634 |
2.21e-94 |
|
cyclohexanecarboxylate-CoA ligase; Reviewed
Pssm-ID: 171961 [Multi-domain] Cd Length: 547 Bit Score: 301.20 E-value: 2.21e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 71 EVDRMVSTPIGGLSYVQGctkkHLNSKTVGQCLETTAQRVPEREALVVLHED----VRLTFAQLKEEVDKAASGLLSIGL 146
Cdd:PRK13295 2 EFDAVLLPPRRAASIAAG----HWHDRTINDDLDACVASCPDKTAVTAVRLGtgapRRFTYRELAALVDRVAVGLARLGV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 147 CKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEvenaq 226
Cdd:PRK13295 78 GRGDVVSCQLPNWWEFTVLYLACSRIGAVLNPLMPIFRERELSFMLKHAESKVLVVPKTFRGFDHAAMARRLRPE----- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 227 pgalksqrLPDLTTVISVDAPLPGTLlldEVVAAGSTRqhlDQLQYNQQFLSCHDP-----INIQFTSGTTGSPKGATLS 301
Cdd:PRK13295 153 --------LPALRHVVVVGGDGADSF---EALLITPAW---EQEPDAPAILARLRPgpddvTQLIYTSGTTGEPKGVMHT 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 302 HYNIVNNSNILGERLKLhekTPEQLrMILPNPLYHCLGSVAGTMMCLMYGATLILASpIFNGKKALEAISRERGTFLYGT 381
Cdd:PRK13295 219 ANTLMANIVPYAERLGL---GADDV-ILMASPMAHQTGFMYGLMMPVMLGATAVLQD-IWDPARAAELIRTEGVTFTMAS 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 382 PTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSPVTFAHfPEDTVEQKAESVGRI 461
Cdd:PRK13295 294 TPFLTDLTRAVKESGRPVSSLRTFLCAGAPIPGALVERARAALGAK-IVSAWGMTENGAVTLTK-LDDPDERASTTDGCP 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 462 MPHTEARIMNmeaGTLAKL--NTPGELCIRGYCVMLGYWGEPQKTeeAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMII 539
Cdd:PRK13295 372 LPGVEVRVVD---ADGAPLpaGQIGRLQVRGCSNFGGYLKRPQLN--GTDADGWFDTGDLARIDADGYIRISGRSKDVII 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 540 RGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKG-KISHFKIPKYIVFVTNYP 618
Cdd:PRK13295 447 RGGENIPVVEIEALLYRHPAIAQVAIVAYPDERLGERACAFVVPRPGQSLDFEEMVEFLKAqKVAKQYIPERLVVRDALP 526
|
570
....*....|....*.
gi 572872742 619 LTISGKIQKFKLREQM 634
Cdd:PRK13295 527 RTPSGKIQKFRLREML 542
|
|
| Acs |
COG0365 |
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]; |
102-635 |
6.18e-94 |
|
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];
Pssm-ID: 440134 [Multi-domain] Cd Length: 565 Bit Score: 300.49 E-value: 6.18e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 102 CLETTAQRVPEREALVVLHED---VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVS 178
Cdd:COG0365 14 CLDRHAEGRGDKVALIWEGEDgeeRTLTYAELRREVNRFANALRALGVKKGDRVAIYLPNIPEAVIAMLACARIGAVHSP 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 179 VNPAYQAMELEYVLKKVGCKALVFpkqfkTQQYYNVLKQIC--PEVENAQpgalksQRLPDLTTVISV-----DAPLPGT 251
Cdd:COG0365 94 VFPGFGAEALADRIEDAEAKVLIT-----ADGGLRGGKVIDlkEKVDEAL------EELPSLEHVIVVgrtgaDVPMEGD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 252 LLLDEVVAAGStrqhlDQLQYNQqfLSCHDPINIQFTSGTTGSPKGATLSHynivnnSNILGERLKLHektpeqlRMIL- 330
Cdd:COG0365 163 LDWDELLAAAS-----AEFEPEP--TDADDPLFILYTSGTTGKPKGVVHTH------GGYLVHAATTA-------KYVLd 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 331 --PNPLYHCLGSVaGTMMCLMY--------GATLIL--ASPIF-NGKKALEAISRERGTFLYGTPTMFVDILNQPDF--S 395
Cdd:COG0365 223 lkPGDVFWCTADI-GWATGHSYivygpllnGATVVLyeGRPDFpDPGRLWELIEKYGVTVFFTAPTAIRALMKAGDEplK 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 396 SYDIST--MCGGviAGSPAPPELIRAIINKINmKDLVVAYGTTEnspvTFAHF--PEDTVEQKAESVGRIMPHTEARIMN 471
Cdd:COG0365 302 KYDLSSlrLLGS--AGEPLNPEVWEWWYEAVG-VPIVDGWGQTE----TGGIFisNLPGLPVKPGSMGKPVPGYDVAVVD 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 472 mEAGTLAKLNTPGELCIRGYC--VMLGYWGEPQKTEEAV--DQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYP 547
Cdd:COG0365 375 -EDGNPVPPGEEGELVIKGPWpgMFRGYWNDPERYRETYfgRFPGWYRTGDGARRDEDGYFWILGRSDDVINVSGHRIGT 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 548 AELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDG---EETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGK 624
Cdd:COG0365 454 AEIESALVSHPAVAEAAVVGVPDEIRGQVVKAFVVLKPGvepSDELAKELQAHVREELGPYAYPREIEFVDELPKTRSGK 533
|
570
....*....|.
gi 572872742 625 IQKFKLREQME 635
Cdd:COG0365 534 IMRRLLRKIAE 544
|
|
| PRK06087 |
PRK06087 |
medium-chain fatty-acid--CoA ligase; |
97-638 |
1.58e-90 |
|
medium-chain fatty-acid--CoA ligase;
Pssm-ID: 180393 [Multi-domain] Cd Length: 547 Bit Score: 291.27 E-value: 1.58e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 97 KTVGQCLETTAQRVPEREAlVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIIL 176
Cdd:PRK06087 23 ASLADYWQQTARAMPDKIA-VVDNHGASYTYSALDHAASRLANWLLAKGIEPGDRVAFQLPGWCEFTIIYLACLKVGAVS 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 177 VSVNPAYQAMELEYVLKKVGCKALVFPKQFKTQQYynvLKQICPEVEnaqpgalksqRLPDLTTVISVD--APLPGTLLL 254
Cdd:PRK06087 102 VPLLPSWREAELVWVLNKCQAKMFFAPTLFKQTRP---VDLILPLQN----------QLPQLQQIVGVDklAPATSSLSL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 255 DEVVAAGSTRQHLDQLQYNQqfLSChdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQLrMILPNPL 334
Cdd:PRK06087 169 SQIIADYEPLTTAITTHGDE--LAA-----VLFTSGTEGLPKGVMLTHNNILASERAYCARLNL---TWQDV-FMMPAPL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 335 YHCLGSVAGTMMCLMYGATLILASpIFNGKKALEAISRERGTFLYG-TPTMFvDILNQPDFSSYDISTM----CGGviag 409
Cdd:PRK06087 238 GHATGFLHGVTAPFLIGARSVLLD-IFTPDACLALLEQQRCTCMLGaTPFIY-DLLNLLEKQPADLSALrfflCGG---- 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 410 SPAPPELIRAIINKiNMKdLVVAYGTTENSPVTFAHfPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAkLNTPGELCIR 489
Cdd:PRK06087 312 TTIPKKVARECQQR-GIK-LLSVYGSTESSPHAVVN-LDDPLSRFMHTDGYAAAGVEIKVVDEARKTLP-PGCEGEEASR 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 490 GYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVK 569
Cdd:PRK06087 388 GPNVFMGYLDEPELTARALDEEGWYYSGDLCRMDEAGYIKITGRKKDIIVRGGENISSREVEDILLQHPKIHDACVVAMP 467
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572872742 570 DDRMGEEICACIRLKDGEET-TVEEIKAF-CKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMERHL 638
Cdd:PRK06087 468 DERLGERSCAYVVLKAPHHSlTLEEVVAFfSRKRVAKYKYPEHIVVIDKLPRTASGKIQKFLLRKDIMRRL 538
|
|
| CHC_CoA_lg |
cd05903 |
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ... |
124-632 |
7.52e-90 |
|
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Cyclohexanecarboxylate-CoA ligase activates the aliphatic ring compound, cyclohexanecarboxylate, for degradation. It catalyzes the synthesis of cyclohexanecarboxylate-CoA thioesters in a two-step reaction involving the formation of cyclohexanecarboxylate-AMP anhydride, followed by the nucleophilic substitution of AMP by CoA.
Pssm-ID: 341229 [Multi-domain] Cd Length: 437 Bit Score: 285.81 E-value: 7.52e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 124 RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFP 203
Cdd:cd05903 1 RLTYSELDTRADRLAAGLAALGVGPGDVVAFQLPNWWEFAVLYLACLRIGAVTNPILPFFREHELAFILRRAKAKVFVVP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 204 KQFKTQQYynvlkqicpevenaqpgalksqrlpdlttvisvdAPLPGtllldevvaagstrqhldqlqynqqflschDPI 283
Cdd:cd05903 81 ERFRQFDP----------------------------------AAMPD------------------------------AVA 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 284 NIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhektPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILASpIFNG 363
Cdd:cd05903 97 LLLFTSGTTGEPKGVMHSHNTLSASIRQYAERLGL----GPGDVFLVASPMAHQTGFVYGFTLPLLLGAPVVLQD-IWDP 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 364 KKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENsPVTF 443
Cdd:cd05903 172 DKALALMREHGVTFMMGATPFLTDLLNAVEEAGEPLSRLRTFVCGGATVPRSLARRAAELLGAK-VCSAYGSTEC-PGAV 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 444 AHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKlNTPGELCIRGYCVMLGYWGEPQKTEEAvDQDKWYWTGDVATMN 523
Cdd:cd05903 250 TSITPAPEDRRLYTDGRPLPGVEIKVVDDTGATLAP-GVEGELLSRGPSVFLGYLDRPDLTADA-APEGWFRTGDLARLD 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 524 EQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGK-I 602
Cdd:cd05903 328 EDGYLRITGRSKDIIIRGGENIPVLEVEDLLLGHPGVIEAAVVALPDERLGERACAVVVTKSGALLTFDELVAYLDRQgV 407
|
490 500 510
....*....|....*....|....*....|
gi 572872742 603 SHFKIPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:cd05903 408 AKQYWPERLVHVDDLPRTPSGKVQKFRLRE 437
|
|
| FadD3 |
cd17638 |
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ... |
281-627 |
1.02e-87 |
|
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ligases, including FadD3 which is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria. The cholesterol catabolic pathway occurs in most mycolic acid-containing actinobacteria, such as Rhodococcus jostii RHA1, and is critical for Mycobacterium tuberculosis (Mtb) during infection. FadD3 catalyzes the ATP-dependent CoA thioesterification of 3a-alpha-H-4alpha(3'-propanoate)-7a-beta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA. Hydroxylated analogs of HIP, 5alpha-OH HIP and 1beta-OH HIP, can also be used.
Pssm-ID: 341293 [Multi-domain] Cd Length: 330 Bit Score: 276.69 E-value: 1.02e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 281 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGATlILASPI 360
Cdd:cd17638 1 DVSDIMFTSGTTGRSKGVMCAHRQTLRAAAAWADCADLTEDD----RYLIINPFFHTFGYKAGIVACLLTGAT-VVPVAV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 361 FNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSP 440
Cdd:cd17638 76 FDVDAILEAIERERITVLPGPPTLFQSLLDHPGRKKFDLSSLRAAVTGAATVPVELVRRMRSELGFETVLTAYGLTEAGV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 441 VTFAHfPEDTVEQKAESVGRIMPHTEARIMNmeagtlaklntPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVA 520
Cdd:cd17638 156 ATMCR-PGDDAETVATTCGRACPGFEVRIAD-----------DGEVLVRGYNVMQGYLDDPEATAEAIDADGWLHTGDVG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 521 TMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKG 600
Cdd:cd17638 224 ELDERGYLRITDRLKDMYIVGGFNVYPAEVEGALAEHPGVAQVAVIGVPDERMGEVGKAFVVARPGVTLTEEDVIAWCRE 303
|
330 340
....*....|....*....|....*..
gi 572872742 601 KISHFKIPKYIVFVTNYPLTISGKIQK 627
Cdd:cd17638 304 RLANYKVPRFVRFLDELPRNASGKVMK 330
|
|
| PRK06710 |
PRK06710 |
long-chain-fatty-acid--CoA ligase; Validated |
103-636 |
3.19e-87 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 180666 [Multi-domain] Cd Length: 563 Bit Score: 283.08 E-value: 3.19e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVVLHEDVrlTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:PRK06710 30 VEQMASRYPEKKALHFLGKDI--TFSVFHDKVKRFANYLQKLGVEKGDRVAIMLPNCPQAVIGYYGTLLAGGIVVQTNPL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKALVfpkqfktqqyynVLKQICPEVENAQpGALKSQRLpdLTTVISVDAPLPGTLLLDEVVAAGS 262
Cdd:PRK06710 108 YTERELEYQLHDSGAKVIL------------CLDLVFPRVTNVQ-SATKIEHV--IVTRIADFLPFPKNLLYPFVQKKQS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 263 ------TRQHLDQL------QYNQQFLSCHDPIN----IQFTSGTTGSPKGATLSHYNIVNNSnILGERLKLHEKTPEQL 326
Cdd:PRK06710 173 nlvvkvSESETIHLwnsvekEVNTGVEVPCDPENdlalLQYTGGTTGFPKGVMLTHKNLVSNT-LMGVQWLYNCKEGEEV 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 327 RM-ILPnpLYHCLGSVAGTMMCLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGG 405
Cdd:PRK06710 252 VLgVLP--FFHVYGMTAVMNLSIMQGYKMVLI-PKFDMKMVFEAIKKHKVTLFPGAPTIYIALLNSPLLKEYDISSIRAC 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 406 VIAGSPAPPElIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDtvEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGE 485
Cdd:PRK06710 329 ISGSAPLPVE-VQEKFETVTGGKLVEGYGLTESSPVTHSNFLWE--KRVPGSIGVPWPDTEAMIMSLETGEALPPGEIGE 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 486 LCIRGYCVMLGYWGEPQKTEeAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQV 565
Cdd:PRK06710 406 IVVKGPQIMKGYWNKPEETA-AVLQDGWLHTGDVGYMDEDGFFYVKDRKKDMIVASGFNVYPREVEEVLYEHEKVQEVVT 484
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572872742 566 VGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMER 636
Cdd:PRK06710 485 IGVPDPYRGETVKAFVVLKEGTECSEEELNQFARKYLAAYKVPKVYEFRDELPKTTVGKILRRVLIEEEKR 555
|
|
| FACL_DitJ_like |
cd05934 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
124-631 |
7.22e-87 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Members of this family include DitJ from Pseudomonas and similar proteins.
Pssm-ID: 341257 [Multi-domain] Cd Length: 422 Bit Score: 277.64 E-value: 7.22e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 124 RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFp 203
Cdd:cd05934 3 RWTYAELLRESARIAAALAALGIRPGDRVALMLDNCPEFLFAWFALAKLGAVLVPINTALRGDELAYIIDHSGAQLVVV- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 204 kqfktqqyynvlkqicpevenaqpgalksqrlpdlttvisvdaplpgtllldevvaagstrqhldqlqynqqflschDPI 283
Cdd:cd05934 82 -----------------------------------------------------------------------------DPA 84
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 284 NIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGATLILAsPIFNG 363
Cdd:cd05934 85 SILYTSGTTGPPKGVVITHANLTFAGYYSARRFGLGEDD----VYLTVLPLFHINAQAVSVLAALSVGATLVLL-PRFSA 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 364 KKALEAISRERGTFLYGTPTMFVDILNQPDfsSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSPVTF 443
Cdd:cd05934 160 SRFWSDVRRYGATVTNYLGAMLSYLLAQPP--SPDDRAHRLRAAYGAPNPPELHEEFEERFGVR-LLEGYGMTETIVGVI 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 444 AHFPEDTveqKAESVGRIMPHTEARIMNMEAGTLAKlNTPGELCIR---GYCVMLGYWGEPQKTEEAVdQDKWYWTGDVA 520
Cdd:cd05934 237 GPRDEPR---RPGSIGRPAPGYEVRIVDDDGQELPA-GEPGELVIRglrGWGFFKGYYNMPEATAEAM-RNGWFHTGDLG 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 521 TMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKG 600
Cdd:cd05934 312 YRDADGFFYFVDRKKDMIRRRGENISSAEVERAILRHPAVREAAVVAVPDEVGEDEVKAVVVLRPGETLDPEELFAFCEG 391
|
490 500 510
....*....|....*....|....*....|.
gi 572872742 601 KISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05934 392 QLAYFKVPRYIRFVDDLPKTPTEKVAKAQLR 422
|
|
| PRK06839 |
PRK06839 |
o-succinylbenzoate--CoA ligase; |
103-633 |
1.53e-82 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 168698 [Multi-domain] Cd Length: 496 Bit Score: 268.65 E-value: 1.53e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVVLHEDvrLTFAQLKEEVDKAASGLL-SIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNP 181
Cdd:PRK06839 8 IEKRAYLHPDRIAIITEEEE--MTYKQLHEYVSKVAAYLIyELNVKKGERIAILSQNSLEYIVLLFAIAKVECIAVPLNI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 182 AYQAMELEYVLKKVGCKALVFPKQFktqqyynvlkqicpevenaQPGALKSQRLPDLTTVISVDAPlpgtllldevvaAG 261
Cdd:PRK06839 86 RLTENELIFQLKDSGTTVLFVEKTF-------------------QNMALSMQKVSYVQRVISITSL------------KE 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 262 STRQHLDQLQYNQQflscHDPINIQFTSGTTGSPKGATLSHYNIVNNS--NILGERLKLHEktpeqlRMILPNPLYHCLG 339
Cdd:PRK06839 135 IEDRKIDNFVEKNE----SASFIICYTSGTTGKPKGAVLTQENMFWNAlnNTFAIDLTMHD------RSIVLLPLFHIGG 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 340 SVAGTMMCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRA 419
Cdd:PRK06839 205 IGLFAFPTLFAGGVIIVPRK-FEPTKALSMIEKHKVTVVMGVPTIHQALINCSKFETTNLQSVRWFYNGGAPCPEELMRE 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 420 IINKINMkdLVVAYGTTENSPVTFAhFPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWG 499
Cdd:PRK06839 284 FIDRGFL--FGQGFGMTETSPTVFM-LSEEDARRKVGSIGKPVLFCDYELID-ENKNKVEVGEVGELLIRGPNVMKEYWN 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 500 EPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICA 579
Cdd:PRK06839 360 RPDATEETI-QDGWLCTGDLARVDEDGFVYIVGRKKEMIISGGENIYPLEVEQVINKLSDVYEVAVVGRQHVKWGEIPIA 438
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 572872742 580 CIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK06839 439 FIVKKSSSVLIEKDVIEHCRLFLAKYKIPKEIVFLKELPKNATGKIQKAQLVNQ 492
|
|
| ttLC_FACS_AEE21_like |
cd12118 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ... |
103-632 |
6.58e-82 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This family includes fatty acyl-CoA synthetases that can activate medium to long-chain fatty acids. These enzymes catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid. Also included in this family are acyl activating enzymes from Arabidopsis, which contains a large number of proteins from this family with up to 63 different genes, many of which are uncharacterized.
Pssm-ID: 341283 [Multi-domain] Cd Length: 486 Bit Score: 266.47 E-value: 6.58e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:cd12118 10 LERAAAVYPDRTSIV--YGDRRYTWRQTYDRCRRLASALAALGISRGDTVAVLAPNTPAMYELHFGVPMAGAVLNALNTR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKALVFPKQFktqQYYNVLKQICPEVENAQPgalksqrlpdlttvisvdaplpgtllLDEvvaags 262
Cdd:cd12118 88 LDAEEIAFILRHSEAKVLFVDREF---EYEDLLAEGDPDFEWIPP--------------------------ADE------ 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 263 trqhldqlqynqqflscHDPINIQFTSGTTGSPKGATLSHYNIVNN--SNILGERLKLHEktpeqlRMILPNPLYHCLG- 339
Cdd:cd12118 133 -----------------WDPIALNYTSGTTGRPKGVVYHHRGAYLNalANILEWEMKQHP------VYLWTLPMFHCNGw 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 340 -------SVAGTMMCLmygatlilasPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPA 412
Cdd:cd12118 190 cfpwtvaAVGGTNVCL----------RKVDAKAIYDLIEKHKVTHFCGAPTVLNMLANAPPSDARPLPHRVHVMTAGAPP 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 413 PPelirAIINKINMKDLVV--AYGTTENS-PVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTP------ 483
Cdd:cd12118 260 PA----AVLAKMEELGFDVthVYGLTETYgPATVCAWKPEWDELPTEERARLKARQGVRYVGLEEVDVLDPETMkpvprd 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 484 ----GELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPK 559
Cdd:cd12118 336 gktiGEIVFRGNIVMKGYLKNPEATAEAF-RGGWFHSGDLAVIHPDGYIEIKDRSKDIIISGGENISSVEVEGVLYKHPA 414
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 572872742 560 VQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVtNYPLTISGKIQKFKLRE 632
Cdd:cd12118 415 VLEAAVVARPDEKWGEVPCAFVELKEGAKVTEEEIIAFCREHLAGFMVPKTVVFG-ELPKTSTGKIQKFVLRD 486
|
|
| ttLC_FACS_AlkK_like |
cd12119 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ... |
103-632 |
1.75e-81 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.
Pssm-ID: 341284 [Multi-domain] Cd Length: 518 Bit Score: 266.42 E-value: 1.75e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVVLHED--VRLTFAQLKEEVDKAASGLLSIGLCKGDRLG--MWgpNSYAWVLMQLATAQAGIILVS 178
Cdd:cd12119 2 LEHAARLHGDREIVSRTHEGevHRYTYAEVAERARRLANALRRLGVKPGDRVAtlAW--NTHRHLELYYAVPGMGAVLHT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 179 VNPAYQAMELEYVLKKVGCKALVFPKQFKtqqyynvlkqicPEVENAQPgalksqRLPDLTTVI----SVDAPLPGTLLL 254
Cdd:cd12119 80 INPRLFPEQIAYIINHAEDRVVFVDRDFL------------PLLEAIAP------RLPTVEHVVvmtdDAAMPEPAGVGV 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 255 ---DEVVAAGSTRQHLDQLQYNqqflschDPINIQFTSGTTGSPKGATLSHYNIV------NNSNILGErlklhektpEQ 325
Cdd:cd12119 142 layEELLAAESPEYDWPDFDEN-------TAAAICYTSGTTGNPKGVVYSHRSLVlhamaaLLTDGLGL---------SE 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 326 LRMILP-NPLYHCLGsvAGT-MMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMC 403
Cdd:cd12119 206 SDVVLPvVPMFHVNA--WGLpYAAAMVGAKLVLPGPYLDPASLAELIEREGVTFAAGVPTVWQGLLDHLEANGRDLSSLR 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 404 GGVIAGSPAPPELIRAIINKInmKDLVVAYGTTENSPV-TFAHFP----EDTVEQKAE---SVGRIMPHTEARIMNMEAG 475
Cdd:cd12119 284 RVVIGGSAVPRSLIEAFEERG--VRVIHAWGMTETSPLgTVARPPsehsNLSEDEQLAlraKQGRPVPGVELRIVDDDGR 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 476 TLAKL-NTPGELCIRGYCVMLGYWGEPQKTEEaVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFF 554
Cdd:cd12119 362 ELPWDgKAVGELQVRGPWVTKSYYKNDEESEA-LTEDGWLRTGDVATIDEDGYLTITDRSKDVIKSGGEWISSVELENAI 440
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 572872742 555 HTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:cd12119 441 MAHPAVAEAAVIGVPHPKWGERPLAVVVLKEGATVTAEELLEFLADKVAKWWLPDDVVFVDEIPKTSTGKIDKKALRE 518
|
|
| FACL_fum10p_like |
cd05926 |
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ... |
111-632 |
3.80e-79 |
|
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Fum10p is a fatty acid CoA ligase involved in the synthesis of fumonisin, a polyketide mycotoxin, in Gibberella moniliformis.
Pssm-ID: 341249 [Multi-domain] Cd Length: 493 Bit Score: 259.55 E-value: 3.80e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 111 PEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEY 190
Cdd:cd05926 1 PDAPALVVPGSTPALTYADLAELVDDLARQLAALGIKKGDRVAIALPNGLEFVVAFLAAARAGAVVAPLNPAYKKAEFEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 191 VLKKVGCKALVFPKQFKTqqyynvlkqicPEVENAQ--PGALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAGSTRQHLD 268
Cdd:cd05926 81 YLADLGSKLVLTPKGELG-----------PASRAASklGLAILELALDVGVLIRAPSAESLSNLLADKKNAKSEGVPLPD 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 269 qlqynqqflschDPINIQFTSGTTGSPKGATLSHYNIVNNS-NILGErlklHEKTPEQlRMILPNPLYHCLGSVAGTMMC 347
Cdd:cd05926 150 ------------DLALILHTSGTTGRPKGVPLTHRNLAASAtNITNT----YKLTPDD-RTLVVMPLFHVHGLVASLLST 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 348 LMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYD-------ISTmcggviAGSPAPPELIRAI 420
Cdd:cd05926 213 LAAGGSVVLP-PRFSASTFWPDVRDYNATWYTAVPTIHQILLNRPEPNPESpppklrfIRS------CSASLPPAVLEAL 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 421 INKINMKdLVVAYGTTENSPVTFAHfPEDTVEQKAESVGRimPH-TEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWG 499
Cdd:cd05926 286 EATFGAP-VLEAYGMTEAAHQMTSN-PLPPGPRKPGSVGK--PVgVEVRILD-EDGEILPPGVVGEICLRGPNVTRGYLN 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 500 EPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICA 579
Cdd:cd05926 361 NPEANAEAAFKDGWFRTGDLGYLDADGYLFLTGRIKELINRGGEKISPLEVDGVLLSHPAVLEAVAFGVPDEKYGEEVAA 440
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 572872742 580 CIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:cd05926 441 AVVLREGASVTEEELRAFCRKHLAAFKVPKKVYFVDELPKTATGKIQRRKVAE 493
|
|
| 4CL |
cd05904 |
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ... |
107-633 |
2.04e-78 |
|
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.
Pssm-ID: 341230 [Multi-domain] Cd Length: 505 Bit Score: 257.93 E-value: 2.04e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 107 AQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAM 186
Cdd:cd05904 15 ASAHPSRPALIDAATGRALTYAELERRVRRLAAGLAKRGGRKGDVVLLLSPNSIEFPVAFLAVLSLGAVVTTANPLSTPA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 187 ELEYVLKKVGCKALvfpkqFKTQQYYNVLKQIcpevenaqpgalksqrlpDLTTVISVDAPLPGTLLLDEVVAAGSTrqh 266
Cdd:cd05904 95 EIAKQVKDSGAKLA-----FTTAELAEKLASL------------------ALPVVLLDSAEFDSLSFSDLLFEADEA--- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 267 ldqlQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILgERLKLHEKTPEQlRMILPNPLYHCLGSVAGTMM 346
Cdd:cd05904 149 ----EPPVVVIKQDDVAALLYSSGTTGRSKGVMLTHRNLIAMVAQF-VAGEGSNSDSED-VFLCVLPMFHIYGLSSFALG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 347 CLMYGATlILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINM 426
Cdd:cd05904 223 LLRLGAT-VVVMPRFDLEELLAAIERYKVTHLPVVPPIVLALVKSPIVDKYDLSSLRQIMSGAAPLGKELIEAFRAKFPN 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 427 KDLVVAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEE 506
Cdd:cd05904 302 VDLGQGYGMTESTGVVAMCFAPEKDRAKYGSVGRLVPNVEAKIVDPETGESLPPNQTGELWIRGPSIMKGYLNNPEATAA 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 507 AVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDG 586
Cdd:cd05904 382 TIDKEGWLHTGDLCYIDEDGYLFIVDRLKELIKYKGFQVAPAELEALLLSHPEILDAAVIPYPDEEAGEVPMAFVVRKPG 461
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 572872742 587 EETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIqkfkLREQ 633
Cdd:cd05904 462 SSLTEDEIMDFVAKQVAPYKKVRKVAFVDAIPKSPSGKI----LRKE 504
|
|
| EntE |
COG1021 |
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ... |
97-636 |
3.63e-78 |
|
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440644 [Multi-domain] Cd Length: 533 Bit Score: 258.15 E-value: 3.63e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 97 KTVGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDR----LgmwgPNSYAWVLMQLATAQA 172
Cdd:COG1021 25 ETLGDLLRRRAERHPDRIAVV--DGERRLSYAELDRRADRLAAGLLALGLRPGDRvvvqL----PNVAEFVIVFFALFRA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 173 GIILVSVNPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICpevenaqpgalksQRLPDLTTVISVDAPLPGTL 252
Cdd:COG1021 99 GAIPVFALPAHRRAEISHFAEQSEAVAYIIPDRHRGFDYRALARELQ-------------AEVPSLRHVLVVGDAGEFTS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 253 LlDEVVAAGStrqhlDQLQYNqqfLSCHDPINIQFTSGTTGSPKGATLSH----YNIVNNSNILGerlkLHEKTpeqlRM 328
Cdd:COG1021 166 L-DALLAAPA-----DLSEPR---PDPDDVAFFQLSGGTTGLPKLIPRTHddylYSVRASAEICG----LDADT----VY 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 329 --ILP---N-PLyhclgSVAGTMMCLMYGATLILA---SPifngKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDI 399
Cdd:COG1021 229 laALPaahNfPL-----SSPGVLGVLYAGGTVVLApdpSP----DTAFPLIERERVTVTALVPPLALLWLDAAERSRYDL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 400 STMcgGVI--AGSPAPPELIRAIINKINMKdLVVAYGTTEnSPVTFAHfPEDTVEQKAESVGR-IMPHTEARIMNmEAGT 476
Cdd:COG1021 300 SSL--RVLqvGGAKLSPELARRVRPALGCT-LQQVFGMAE-GLVNYTR-LDDPEEVILTTQGRpISPDDEVRIVD-EDGN 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 477 LAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHT 556
Cdd:COG1021 374 PVPPGEVGELLTRGPYTIRGYYRAPEHNARAFTPDGFYRTGDLVRRTPDGYLVVEGRAKDQINRGGEKIAAEEVENLLLA 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 557 HPKVQEVQVVGVKDDRMGEEICACIRLkDGEETTVEEIKAFCKGK-ISHFKIPKYIVFVTNYPLTISGKIQKFKLREQME 635
Cdd:COG1021 454 HPAVHDAAVVAMPDEYLGERSCAFVVP-RGEPLTLAELRRFLRERgLAAFKLPDRLEFVDALPLTAVGKIDKKALRAALA 532
|
.
gi 572872742 636 R 636
Cdd:COG1021 533 A 533
|
|
| PRK08974 |
PRK08974 |
long-chain-fatty-acid--CoA ligase FadD; |
103-633 |
9.40e-76 |
|
long-chain-fatty-acid--CoA ligase FadD;
Pssm-ID: 236359 [Multi-domain] Cd Length: 560 Bit Score: 252.67 E-value: 9.40e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVVLHEdvRLTFAQLkEEVDKAASGLLS--IGLCKGDRLGMWGPNsyawvLMQLATA-----QAGII 175
Cdd:PRK08974 29 FEQAVARYADQPAFINMGE--VMTFRKL-EERSRAFAAYLQngLGLKKGDRVALMMPN-----LLQYPIAlfgilRAGMI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 176 LVSVNPAYQAMELEYVLKKVGCKALVFPKQFKtqqyyNVLKQIcpeVENAQPGALKSQRLPDLTtvisvdaPLPGTLLLD 255
Cdd:PRK08974 101 VVNVNPLYTPRELEHQLNDSGAKAIVIVSNFA-----HTLEKV---VFKTPVKHVILTRMGDQL-------STAKGTLVN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 256 EVV-------------AAGSTRQHLD---QLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNN--------SNI 311
Cdd:PRK08974 166 FVVkyikrlvpkyhlpDAISFRSALHkgrRMQYVKPELVPEDLAFLQYTGGTTGVAKGAMLTHRNMLANleqakaayGPL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 312 LGERLKLhektpeqlrMILPNPLYHCLgsvAGTMMCLMY---GATLILaspIFNGKKA---LEAISRERGTFLYGTPTMF 385
Cdd:PRK08974 246 LHPGKEL---------VVTALPLYHIF---ALTVNCLLFielGGQNLL---ITNPRDIpgfVKELKKYPFTAITGVNTLF 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 386 VDILNQPDFSSYDISTMCGGVIAGSPAPpeliRAIINK---INMKDLVVAYGTTENSPVTFAHfPEDTVEQKAeSVGRIM 462
Cdd:PRK08974 311 NALLNNEEFQELDFSSLKLSVGGGMAVQ----QAVAERwvkLTGQYLLEGYGLTECSPLVSVN-PYDLDYYSG-SIGLPV 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 463 PHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEaVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGG 542
Cdd:PRK08974 385 PSTEIKLVD-DDGNEVPPGEPGELWVKGPQVMLGYWQRPEATDE-VIKDGWLATGDIAVMDEEGFLRIVDRKKDMILVSG 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 543 ENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDgEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTIS 622
Cdd:PRK08974 463 FNVYPNEIEDVVMLHPKVLEVAAVGVPSEVSGEAVKIFVVKKD-PSLTEEELITHCRRHLTGYKVPKLVEFRDELPKSNV 541
|
570
....*....|.
gi 572872742 623 GKIQKFKLREQ 633
Cdd:PRK08974 542 GKILRRELRDE 552
|
|
| PRK05605 |
PRK05605 |
long-chain-fatty-acid--CoA ligase; Validated |
103-636 |
4.30e-75 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235531 [Multi-domain] Cd Length: 573 Bit Score: 251.07 E-value: 4.30e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVVLHEdvRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:PRK05605 38 YDNAVARFGDRPALDFFGA--TTTYAELGKQVRRAAAGLRALGVRPGDRVAIVLPNCPQHIVAFYAVLRLGAVVVEHNPL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCK-ALVFPKqfktqqyynvlkqICPEVEnaqpgalksqRLPD---LTTVISVD------------- 245
Cdd:PRK05605 116 YTAHELEHPFEDHGARvAIVWDK-------------VAPTVE----------RLRRttpLETIVSVNmiaampllqrlal 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 246 ---------------APLPGTLLLDEVVAAGSTrqhLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVnnSN 310
Cdd:PRK05605 173 rlpipalrkaraaltGPAPGTVPWETLVDAAIG---GDGSDVSHPRPTPDDVALILYTSGTTGKPKGAQLTHRNLF--AN 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 311 ILGERLKLHEKTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILN 390
Cdd:PRK05605 248 AAQGKAWVPGLGDGPERVLAALPMFHAYGLTLCLTLAVSIGGELVLL-PAPDIDLILDAMKKHPPTWLPGVPPLYEKIAE 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 391 QPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSPVTFAHFPEDTveQKAESVGRIMPHTEARIM 470
Cdd:PRK05605 327 AAEERGVDLSGVRNAFSGAMALPVSTVELWEKLTGGL-LVEGYGLTETSPIIVGNPMSDD--RRPGYVGVPFPDTEVRIV 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 471 NME--AGTLAKlNTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPA 548
Cdd:PRK05605 404 DPEdpDETMPD-GEEGELLVRGPQVFKGYWNRPEETAKSF-LDGWFRTGDVVVMEEDGFIRIVDRIKELIITGGFNVYPA 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 549 ELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKF 628
Cdd:PRK05605 482 EVEEVLREHPGVEDAAVVGLPREDGSEEVVAAVVLEPGAALDPEGLRAYCREHLTRYKVPRRFYHVDELPRDQLGKVRRR 561
|
....*...
gi 572872742 629 KLREQMER 636
Cdd:PRK05605 562 EVREELLE 569
|
|
| PRK08314 |
PRK08314 |
long-chain-fatty-acid--CoA ligase; Validated |
103-633 |
5.16e-75 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236235 [Multi-domain] Cd Length: 546 Bit Score: 250.26 E-value: 5.16e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLS-IGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNP 181
Cdd:PRK08314 16 LEVSARRYPDKTAIV--FYGRAISYRELLEEAERLAGYLQQeCGVRKGDRVLLYMQNSPQFVIAYYAILRANAVVVPVNP 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 182 AYQAMELEYVLKKVGCKALVFpkqfkTQQYYNVLKQICPEVENAQ------PGALKSQ---RLPDLttvISVDAPLP--- 249
Cdd:PRK08314 94 MNREEELAHYVTDSGARVAIV-----GSELAPKVAPAVGNLRLRHvivaqySDYLPAEpeiAVPAW---LRAEPPLQala 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 250 --GTLLLDEVVAAGST----RQHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIvnNSNILGERLkLHEKTP 323
Cdd:PRK08314 166 pgGVVAWKEALAAGLAppphTAGPDDLAV------------LPYTSGTTGVPKGCMHTHRTV--MANAVGSVL-WSNSTP 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 324 EQLrMILPNPLYHCLGSVAGTMMCLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMC 403
Cdd:PRK08314 231 ESV-VLAVLPLFHVTGMVHSMNAPIYAGATVVLM-PRWDREAAARLIERYRVTHWTNIPTMVVDFLASPGLAERDLSSLR 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 404 ggVIAGSPAP-PElirAIINKinMKDL-----VVAYGTTENspVTFAHF-PEDtvEQKAESVGriMPH--TEARIMNMEa 474
Cdd:PRK08314 309 --YIGGGGAAmPE---AVAER--LKELtgldyVEGYGLTET--MAQTHSnPPD--RPKLQCLG--IPTfgVDARVIDPE- 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 475 gTLAKL--NTPGELCIRGYCVMLGYWGEPQKTEEA---VDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAE 549
Cdd:PRK08314 375 -TLEELppGEVGEIVVHGPQVFKGYWNRPEATAEAfieIDGKRFFRTGDLGRMDEEGYFFITDRLKRMINASGFKVWPAE 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 550 LEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEE--TTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 627
Cdd:PRK08314 454 VENLLYKHPAIQEACVIATPDPRRGETVKAVVVLRPEARgkTTEEEIIAWAREHMAAYKYPRIVEFVDSLPKSGSGKILW 533
|
....*.
gi 572872742 628 FKLREQ 633
Cdd:PRK08314 534 RQLQEQ 539
|
|
| PRK06188 |
PRK06188 |
acyl-CoA synthetase; Validated |
98-633 |
1.39e-74 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235731 [Multi-domain] Cd Length: 524 Bit Score: 248.36 E-value: 1.39e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 98 TVGQCLETTAQRVPEREALVVlhEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSyAWVLMQLATAQ-AGIIL 176
Cdd:PRK06188 13 TYGHLLVSALKRYPDRPALVL--GDTRLTYGQLADRISRYIQAFEALGLGTGDAVALLSLNR-PEVLMAIGAAQlAGLRR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 177 VSVNPAYQAMELEYVLKKVGCKALVF-PKQFktqqyynvlkqicpeVENAqpGALKsQRLPDLTTVISVDAPLPGTLLLD 255
Cdd:PRK06188 90 TALHPLGSLDDHAYVLEDAGISTLIVdPAPF---------------VERA--LALL-ARVPSLKHVLTLGPVPDGVDLLA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 256 EVVAAGSTRQHLDQLQynqqflscHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhektPEQLRMILPNPLY 335
Cdd:PRK06188 152 AAAKFGPAPLVAAALP--------PDIAGLAYTGGTTGKPKGVMGTHRSIATMAQIQLAEWEW----PADPRFLMCTPLS 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 336 HclgsVAGTMM--CLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAP 413
Cdd:PRK06188 220 H----AGGAFFlpTLLRGGTVIVL-AKFDPAEVLRAIEEQRITATFLVPTMIYALLDHPDLRTRDLSSLETVYYGASPMS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 414 PELIRAIINKINmKDLVVAYGTTE-NSPVTF----AHFPEDtvEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCI 488
Cdd:PRK06188 295 PVRLAEAIERFG-PIFAQYYGQTEaPMVITYlrkrDHDPDD--PKRLTSCGRPTPGLRVALLD-EDGREVAQGEVGEICV 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 489 RGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGV 568
Cdd:PRK06188 371 RGPLVMDGYWNRPEETAEAF-RDGWLHTGDVAREDEDGFYYIVDRKKDMIVTGGFNVFPREVEDVLAEHPAVAQVAVIGV 449
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572872742 569 KDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK06188 450 PDEKWGEAVTAVVVLRPGAAVDAAELQAHVKERKGSVHAPKQVDFVDSLPLTALGKPDKKALRAR 514
|
|
| PRK12492 |
PRK12492 |
long-chain-fatty-acid--CoA ligase; Provisional |
97-632 |
1.23e-73 |
|
long-chain-fatty-acid--CoA ligase; Provisional
Pssm-ID: 171539 [Multi-domain] Cd Length: 562 Bit Score: 247.04 E-value: 1.23e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 97 KTVGQCLETTAQRVPEREALVVLheDVRLTFAQLkEEVDKAASGLLS--IGLCKGDRLGMWGPNSYAWVLMQLATAQAGI 174
Cdd:PRK12492 24 KSVVEVFERSCKKFADRPAFSNL--GVTLSYAEL-ERHSAAFAAYLQqhTDLVPGDRIAVQMPNVLQYPIAVFGALRAGL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 175 ILVSVNPAYQAMELEYVLKKVGCKALVFPKQFKtqqyyNVLKQICPEVE-----NAQPGALksqrLPDL------TTVIS 243
Cdd:PRK12492 101 IVVNTNPLYTAREMRHQFKDSGARALVYLNMFG-----KLVQEVLPDTGieyliEAKMGDL----LPAAkgwlvnTVVDK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 244 VDAPLPGTLLLDEVVAAGSTRQHLDQ-LQYNQQFLSchDPINIQFTSGTTGSPKGATLSHYNIVnnSNILGERLKLHEKT 322
Cdd:PRK12492 172 VKKMVPAYHLPQAVPFKQALRQGRGLsLKPVPVGLD--DIAVLQYTGGTTGLAKGAMLTHGNLV--ANMLQVRACLSQLG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 323 PE--------QLRMILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDF 394
Cdd:PRK12492 248 PDgqplmkegQEVMIAPLPLYHIYAFTANCMCMMVSGNHNVLITNPRDIPGFIKELGKWRFSALLGLNTLFVALMDHPGF 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 395 SSYDISTMCGGVIAGSPappeLIRAIINK---INMKDLVVAYGTTENSPVTFAHfPEDTvEQKAESVGRIMPHTEARIMN 471
Cdd:PRK12492 328 KDLDFSALKLTNSGGTA----LVKATAERweqLTGCTIVEGYGLTETSPVASTN-PYGE-LARLGTVGIPVPGTALKVID 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 472 MEAGTLAkLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELE 551
Cdd:PRK12492 402 DDGNELP-LGERGELCIKGPQVMKGYWQQPEATAEALDAEGWFKTGDIAVIDPDGFVRIVDRKKDLIIVSGFNVYPNEIE 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 552 DFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGeETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:PRK12492 481 DVVMAHPKVANCAAIGVPDERSGEAVKLFVVARDP-GLSVEELKAYCKENFTGYKVPKHIVLRDSLPMTPVGKILRRELR 559
|
.
gi 572872742 632 E 632
Cdd:PRK12492 560 D 560
|
|
| FAA1 |
COG1022 |
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; |
97-572 |
2.78e-73 |
|
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];
Pssm-ID: 440645 [Multi-domain] Cd Length: 603 Bit Score: 246.94 E-value: 2.78e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 97 KTVGQCLETTAQRVPEREALVVLHED--VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGI 174
Cdd:COG1022 11 DTLPDLLRRRAARFPDRVALREKEDGiwQSLTWAEFAERVRALAAGLLALGVKPGDRVAILSDNRPEWVIADLAILAAGA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 175 ILVSVNPAYQAMELEYVLKKVGCKALVFpkqfKTQQYYNVLKQICPEvenaqpgalksqrLPDLTTVISVDAP----LPG 250
Cdd:COG1022 91 VTVPIYPTSSAEEVAYILNDSGAKVLFV----EDQEQLDKLLEVRDE-------------LPSLRHIVVLDPRglrdDPR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 251 TLLLDEVVAAGSTRQHLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpEQLrMIL 330
Cdd:COG1022 154 LLSLDELLALGREVADPAELEARRAAVKPDDLATIIYTSGTTGRPKGVMLTHRNLLSNARALLERLPLGPGD-RTL-SFL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 331 PnpLYHCLGSVAGtMMCLMYGA--------------------TLILASP-----------------------IFN----- 362
Cdd:COG1022 232 P--LAHVFERTVS-YYALAAGAtvafaespdtlaedlrevkpTFMLAVPrvwekvyagiqakaeeagglkrkLFRwalav 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 363 GKKALEAISRERG-TFLYGTPTMFVDILNqpdFSSydISTMCGG-----VIAGSPAPPELIR---AI-INkinmkdLVVA 432
Cdd:COG1022 309 GRRYARARLAGKSpSLLLRLKHALADKLV---FSK--LREALGGrlrfaVSGGAALGPELARffrALgIP------VLEG 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 433 YGTTENSPVTFAHFPEDtveQKAESVGRIMPHTEARImnmeagtlaklNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDK 512
Cdd:COG1022 378 YGLTETSPVITVNRPGD---NRIGTVGPPLPGVEVKI-----------AEDGEILVRGPNVMKGYYKNPEATAEAFDADG 443
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572872742 513 WYWTGDVATMNEQGFCKIVGRSKDMII-RGGENIYPAELEDFFHTHPKVQEVQVVGvkDDR 572
Cdd:COG1022 444 WLHTGDIGELDEDGFLRITGRKKDLIVtSGGKNVAPQPIENALKASPLIEQAVVVG--DGR 502
|
|
| PRK06145 |
PRK06145 |
acyl-CoA synthetase; Validated |
107-635 |
5.77e-73 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 102207 [Multi-domain] Cd Length: 497 Bit Score: 243.25 E-value: 5.77e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 107 AQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAM 186
Cdd:PRK06145 12 ARRTPDRAALV--YRDQEISYAEFHQRILQAAGMLHARGIGQGDVVALLMKNSAAFLELAFAASYLGAVFLPINYRLAAD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 187 ELEYVLKKVGCKALVFPKQFktqqyynvlkqicpeveNAQPGALKSQrlpdlttvisvdaplpgtLLLDEVVAAGSTRQH 266
Cdd:PRK06145 90 EVAYILGDAGAKLLLVDEEF-----------------DAIVALETPK------------------IVIDAAAQADSRRLA 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 267 LDQLQYNQQFLSC-HDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGTM 345
Cdd:PRK06145 135 QGGLEIPPQAAVApTDLVRLMYTSGTTDRPKGVMHSYGNLHWKSIDHVIALGLTASE----RLLVVGPLYHVGAFDLPGI 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 346 MCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKIN 425
Cdd:PRK06145 211 AVLWVGGTLRIHRE-FDPEAVLAAIERHRLTCAWMAPVMLSRVLTVPDRDRFDLDSLAWCIGGGEKTPESRIRDFTRVFT 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 426 MKDLVVAYGTTENspVTFAHFPEDTVE-QKAESVGRIMPHTEARIMNMEAGTLAKlNTPGELCIRGYCVMLGYWGEPQKT 504
Cdd:PRK06145 290 RARYIDAYGLTET--CSGDTLMEAGREiEKIGSTGRALAHVEIRIADGAGRWLPP-NMKGEICMRGPKVTKGYWKDPEKT 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 505 EEAVDQDkWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLK 584
Cdd:PRK06145 367 AEAFYGD-WFRSGDVGYLDEEGFLYLTDRKKDMIISGGENIASSEVERVIYELPEVAEAAVIGVHDDRWGERITAVVVLN 445
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 572872742 585 DGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQME 635
Cdd:PRK06145 446 PGATLTLEALDRHCRQRLASFKVPRQLKVRDELPRNPSGKVLKRVLRDELN 496
|
|
| PRK07059 |
PRK07059 |
Long-chain-fatty-acid--CoA ligase; Validated |
98-631 |
1.83e-72 |
|
Long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235923 [Multi-domain] Cd Length: 557 Bit Score: 243.77 E-value: 1.83e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 98 TVGQCLETTAQRVPEREALVVLheDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILV 177
Cdd:PRK07059 24 SLADLLEESFRQYADRPAFICM--GKAITYGELDELSRALAAWLQSRGLAKGARVAIMMPNVLQYPVAIAAVLRAGYVVV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 178 SVNPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVENAQPG---ALKS-------QRLPDLTTVISvdap 247
Cdd:PRK07059 102 NVNPLYTPRELEHQLKDSGAEAIVVLENFATTVQQVLAKTAVKHVVVASMGdllGFKGhivnfvvRRVKKMVPAWS---- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 248 LPGTLLLDEVVAAGSTrqhldqLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVnnSNILGERLKLH-----EKT 322
Cdd:PRK07059 178 LPGHVRFNDALAEGAR------QTFKPVKLGPDDVAFLQYTGGTTGVSKGATLLHRNIV--ANVLQMEAWLQpafekKPR 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 323 PEQLRMILPNPLYHCLGSVAGTMMCLMYGATLIL-ASP--IFNGKKALEaisRERGTFLYGTPTMFVDILNQPDFSSYDI 399
Cdd:PRK07059 250 PDQLNFVCALPLYHIFALTVCGLLGMRTGGRNILiPNPrdIPGFIKELK---KYQVHIFPAVNTLYNALLNNPDFDKLDF 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 400 STMcGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHfPEDTVEQKAeSVGRIMPHTEARIMNmEAGTLAK 479
Cdd:PRK07059 327 SKL-IVANGGGMAVQRPVAERWLEMTGCPITEGYGLSETSPVATCN-PVDATEFSG-TIGLPLPSTEVSIRD-DDGNDLP 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 480 LNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPK 559
Cdd:PRK07059 403 LGEPGEICIRGPQVMAGYWNRPDETAKVMTADGFFRTGDVGVMDERGYTKIVDRKKDMILVSGFNVYPNEIEEVVASHPG 482
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 572872742 560 VQEVQVVGVKDDRMGEEICACIRLKDgEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:PRK07059 483 VLEVAAVGVPDEHSGEAVKLFVVKKD-PALTEEDVKAFCKERLTNYKRPKFVEFRTELPKTNVGKILRRELR 553
|
|
| LC_FACS_like |
cd05935 |
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ... |
124-625 |
3.23e-72 |
|
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain fatty acyl-CoA synthetases, which catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters.
Pssm-ID: 341258 [Multi-domain] Cd Length: 430 Bit Score: 239.30 E-value: 3.23e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 124 RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVfp 203
Cdd:cd05935 1 SLTYLELLEVVKKLASFLSNKGVRKGDRVGICLQNSPQYVIAYFAIWRANAVVVPINPMLKERELEYILNDSGAKVAV-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 204 kqfktqqyynvlkqicpevenaqpgalksqrlpdlttvisvdaplpgtllldevvaAGSTrqhLDQLQYnqqflschdpi 283
Cdd:cd05935 79 --------------------------------------------------------VGSE---LDDLAL----------- 88
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 284 nIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQLrMILPNPLYHCLGSVaGTMMCLMY-GATLILASpIFN 362
Cdd:cd05935 89 -IPYTSGTTGLPKGCMHTHFSAAANALQSAVWTGL---TPSDV-ILACLPLFHVTGFV-GSLNTAVYvGGTYVLMA-RWD 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 363 GKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMkDLVVAYGTTENSPVT 442
Cdd:cd05935 162 RETALELIEKYKVTFWTNIPTMLVDLLATPEFKTRDLSSLKVLTGGGAPMPPAVAEKLLKLTGL-RFVEGYGLTETMSQT 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 443 FAHFPEdtvEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEA---VDQDKWYWTGDV 519
Cdd:cd05935 241 HTNPPL---RPKLQCLGIP*FGVDARVIDIETGRELPPNEVGEIVVRGPQIFKGYWNRPEETEESfieIKGRRFFRTGDL 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 520 ATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGE--ETTVEEIKAF 597
Cdd:cd05935 318 GYMDEEGYFFFVDRVKRMINVSGFKVWPAEVEAKLYKHPAI*EVCVISVPDERVGEEVKAFIVLRPEYrgKVTEEDIIEW 397
|
490 500
....*....|....*....|....*...
gi 572872742 598 CKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:cd05935 398 AREQMAAYKYPREVEFVDELPRSASGKI 425
|
|
| PRK08162 |
PRK08162 |
acyl-CoA synthetase; Validated |
103-634 |
2.90e-71 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236169 [Multi-domain] Cd Length: 545 Bit Score: 240.23 E-value: 2.90e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:PRK08162 24 LERAAEVYPDRPAVI--HGDRRRTWAETYARCRRLASALARRGIGRGDTVAVLLPNIPAMVEAHFGVPMAGAVLNTLNTR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKALVFPKQFKtqqyyNVLKQicpevenaqpgALKSQRLPDLTTVISVDAPLPGTllldevvaags 262
Cdd:PRK08162 102 LDAASIAFMLRHGEAKVLIVDTEFA-----EVARE-----------ALALLPGPKPLVIDVDDPEYPGG----------- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 263 trQHLDQLQYnQQFLSCHDP-------------INIQFTSGTTGSPKGATLSHYNIVNN--SNILGERLKLHektPEQLR 327
Cdd:PRK08162 155 --RFIGALDY-EAFLASGDPdfawtlpadewdaIALNYTSGTTGNPKGVVYHHRGAYLNalSNILAWGMPKH---PVYLW 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 328 MIlpnPLYHCLG--------SVAGTMMCLMYgatlilaspiFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDI 399
Cdd:PRK08162 229 TL---PMFHCNGwcfpwtvaARAGTNVCLRK----------VDPKLIFDLIREHGVTHYCGAPIVLSALINAPAEWRAGI 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 400 STMCGGVIAGSPAPPelirAIINKinMK----DLVVAYGTTEN-SPVTF----AHFPEDTVEQKAESVGR--IMPHTEAR 468
Cdd:PRK08162 296 DHPVHAMVAGAAPPA----AVIAK--MEeigfDLTHVYGLTETyGPATVcawqPEWDALPLDERAQLKARqgVRYPLQEG 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 469 IMNMEAGTLAKL----NTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGEN 544
Cdd:PRK08162 370 VTVLDPDTMQPVpadgETIGEIMFRGNIVMKGYLKNPKATEEAF-AGGWFHTGDLAVLHPDGYIKIKDRSKDIIISGGEN 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 545 IYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFvTNYPLTISGK 624
Cdd:PRK08162 449 ISSIEVEDVLYRHPAVLVAAVVAKPDPKWGEVPCAFVELKDGASATEEEIIAHCREHLAGFKVPKAVVF-GELPKTSTGK 527
|
570
....*....|
gi 572872742 625 IQKFKLREQM 634
Cdd:PRK08162 528 IQKFVLREQA 537
|
|
| MCS |
cd05941 |
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ... |
124-632 |
3.45e-71 |
|
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step reaction consisting of the adenylation of malonate with ATP, followed by malonyl transfer from malonyl-AMP to CoA. Malonic acid and its derivatives are the building blocks of polyketides and malonyl-CoA serves as the substrate of polyketide synthases. Malonyl-CoA synthetase has broad substrate tolerance and can activate a variety of malonyl acid derivatives. MCS may play an important role in biosynthesis of polyketides, the important secondary metabolites with therapeutic and agrochemical utility.
Pssm-ID: 341264 [Multi-domain] Cd Length: 442 Bit Score: 236.80 E-value: 3.45e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 124 RLTFAQLKEEVDKAASGLLSIG-LCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKkvgckalvf 202
Cdd:cd05941 11 SITYADLVARAARLANRLLALGkDLRGDRVAFLAPPSAEYVVAQLAIWRAGGVAVPLNPSYPLAELEYVIT--------- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 203 pkqfktqqyynvlkqicpeveNAQPgalksqrlpdlttvisvdaplpgTLLLDevvaagstrqhldqlqynqqflschdP 282
Cdd:cd05941 82 ---------------------DSEP-----------------------SLVLD--------------------------P 91
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 283 INIQFTSGTTGSPKGATLSHYNIVNNSNILgerLKLHEKTPEQlRMILPNPLYHCLGSVAGTMMCLMYGATLILaSPIFN 362
Cdd:cd05941 92 ALILYTSGTTGRPKGVVLTHANLAANVRAL---VDAWRWTEDD-VLLHVLPLHHVHGLVNALLCPLFAGASVEF-LPKFD 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 363 GKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGG-------VIAGSPAPPELIRAIINKINMKDLVVAYGT 435
Cdd:cd05941 167 PKEVAISRLMPSITVFMGVPTIYTRLLQYYEAHFTDPQFARAAaaerlrlMVSGSAALPVPTLEEWEAITGHTLLERYGM 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 436 TENSPVTFAhfPEDTvEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYW 515
Cdd:cd05941 247 TEIGMALSN--PLDG-ERRPGTVGMPLPGVQARIVDEETGEPLPRGEVGEIQVRGPSVFKEYWNKPEATKEEFTDDGWFK 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 516 TGDVATMNEQGFCKIVGRSKDMII-RGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEET-TVEE 593
Cdd:cd05941 324 TGDLGVVDEDGYYWILGRSSVDIIkSGGYKVSALEIERVLLAHPGVSECAVIGVPDPDWGERVVAVVVLRAGAAAlSLEE 403
|
490 500 510
....*....|....*....|....*....|....*....
gi 572872742 594 IKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:cd05941 404 LKEWAKQRLAPYKRPRRLILVDELPRNAMGKVNKKELRK 442
|
|
| PRK08751 |
PRK08751 |
long-chain fatty acid--CoA ligase; |
97-632 |
5.76e-70 |
|
long-chain fatty acid--CoA ligase;
Pssm-ID: 181546 [Multi-domain] Cd Length: 560 Bit Score: 237.08 E-value: 5.76e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 97 KTVGQCLETTAQRVPEREALVVLHEdvRLTFAQLKEEVDKAASGLLS-IGLCKGDRLGMWGPNSYAWVLMQLATAQAGII 175
Cdd:PRK08751 25 RTVAEVFATSVAKFADRPAYHSFGK--TITYREADQLVEQFAAYLLGeLQLKKGDRVALMMPNCLQYPIATFGVLRAGLT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 176 LVSVNPAYQAMELEYVLKKVGCKALVFPKQFKT--QQYY--NVLKQICP----EVENAQPGALKSQRLPDLTTVISvDAP 247
Cdd:PRK08751 103 VVNVNPLYTPRELKHQLIDSGASVLVVIDNFGTtvQQVIadTPVKQVITtglgDMLGFPKAALVNFVVKYVKKLVP-EYR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 248 LPGTLLLDEVVAAGStRQHLDQLQYNqqflscHDPIN-IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQL 326
Cdd:PRK08751 182 INGAIRFREALALGR-KHSMPTLQIE------PDDIAfLQYTGGTTGVAKGAMLTHRNLVANMQQAHQWLAGTGKLEEGC 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 327 RMILPN-PLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTM--- 402
Cdd:PRK08751 255 EVVITAlPLYHIFALTANGLVFMKIGGCNHLISNPRDMPGFVKELKKTRFTAFTGVNTLFNGLLNTPGFDQIDFSSLkmt 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 403 CGGVIAGSPAPPELIRaiinKINMKDLVVAYGTTENSPVTFAHfPEDTVEQKAeSVGRIMPHTEARIMNmEAGTLAKLNT 482
Cdd:PRK08751 335 LGGGMAVQRSVAERWK----QVTGLTLVEAYGLTETSPAACIN-PLTLKEYNG-SIGLPIPSTDACIKD-DAGTVLAIGE 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 483 PGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQE 562
Cdd:PRK08751 408 IGELCIKGPQVMKGYWKRPEETAKVMDADGWLHTGDIARMDEQGFVYIVDRKKDMILVSGFNVYPNEIEDVIAMMPGVLE 487
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 563 VQVVGVKDDRMGEEICACIRLKDgEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:PRK08751 488 VAAVGVPDEKSGEIVKVVIVKKD-PALTAEDVKAHARANLTGYKQPRIIEFRKELPKTNVGKILRRELRD 556
|
|
| PRK07529 |
PRK07529 |
AMP-binding domain protein; Validated |
103-632 |
1.67e-68 |
|
AMP-binding domain protein; Validated
Pssm-ID: 236043 [Multi-domain] Cd Length: 632 Bit Score: 234.85 E-value: 1.67e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVVLH------EDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNS--YAWVLmqLATAQAGI 174
Cdd:PRK07529 31 LSRAAARHPDAPALSFLLdadpldRPETWTYAELLADVTRTANLLHSLGVGPGDVVAFLLPNLpeTHFAL--WGGEAAGI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 175 IlVSVNPAYQAMELEYVLKKVGCKALV----FPKQfktqqyynvlkQICPEVENAQPgalksqRLPDLTTVISVDAPLPG 250
Cdd:PRK07529 109 A-NPINPLLEPEQIAELLRAAGAKVLVtlgpFPGT-----------DIWQKVAEVLA------ALPELRTVVEVDLARYL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 251 TLLLDEVVAAGSTRQHLDQLQYNQQF-------LSCHDPINIQ-----F-TSGTTGSPKGATLSHYNIVNNSNILGERLK 317
Cdd:PRK07529 171 PGPKRLAVPLIRRKAHARILDFDAELarqpgdrLFSGRPIGPDdvaayFhTGGTTGMPKLAQHTHGNEVANAWLGALLLG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 318 L-HEKTpeqlrMILPNPLYHCLGSVAGTMMCLMYGATLILASPI-FNGKKAL----EAISRERGTFLYGTPTMFVDILNQ 391
Cdd:PRK07529 251 LgPGDT-----VFCGLPLFHVNALLVTGLAPLARGAHVVLATPQgYRGPGVIanfwKIVERYRINFLSGVPTVYAALLQV 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 392 PdFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSPVTFAHFPEDtvEQKAESVGRIMPHTEARIMN 471
Cdd:PRK07529 326 P-VDGHDISSLRYALCGAAPLPVEVFRRFEAATGVR-IVEGYGLTEATCVSSVNPPDG--ERRIGSVGLRLPYQRVRVVI 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 472 M-EAGTL---AKLNTPGELCIRGYCVMLGYWgEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYP 547
Cdd:PRK07529 402 LdDAGRYlrdCAVDEVGVLCIAGPNVFSGYL-EAAHNKGLWLEDGWLNTGDLGRIDADGYFWLTGRAKDLIIRGGHNIDP 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 548 AELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISH-FKIPKYIVFVTNYPLTISGKIQ 626
Cdd:PRK07529 481 AAIEEALLRHPAVALAAAVGRPDAHAGELPVAYVQLKPGASATEAELLAFARDHIAErAAVPKHVRILDALPKTAVGKIF 560
|
....*.
gi 572872742 627 KFKLRE 632
Cdd:PRK07529 561 KPALRR 566
|
|
| PRK08276 |
PRK08276 |
long-chain-fatty-acid--CoA ligase; Validated |
115-633 |
4.77e-68 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236215 [Multi-domain] Cd Length: 502 Bit Score: 230.18 E-value: 4.77e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 115 ALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKK 194
Cdd:PRK08276 2 AVIMAPSGEVVTYGELEARSNRLAHGLRALGLREGDVVAILLENNPEFFEVYWAARRSGLYYTPINWHLTAAEIAYIVDD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 195 VGCKALVFpkqfkTQQYYNVLKQICPEVENaqpgalksqrlpDLTTVISVDAPLPGTLLLDEVVAAGSTRQHLDQLqynq 274
Cdd:PRK08276 82 SGAKVLIV-----SAALADTAAELAAELPA------------GVPLLLVVAGPVPGFRSYEEALAAQPDTPIADET---- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 275 qfLSCHdpinIQFTSGTTGSPKG--ATLSHYNIVNNSN----ILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGtMMCL 348
Cdd:PRK08276 141 --AGAD----MLYSSGTTGRPKGikRPLPGLDPDEAPGmmlaLLGFGMYGGPDS----VYLSPAPLYHTAPLRFG-MSAL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 349 MYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDF--SSYDISTMCGGVIAGSPAPPELIRAIIN---K 423
Cdd:PRK08276 210 ALGGTVVVM-EKFDAEEALALIERYRVTHSQLVPTMFVRMLKLPEEvrARYDVSSLRVAIHAAAPCPVEVKRAMIDwwgP 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 424 InmkdLVVAYGTTENSPVTFAHfPEDTVEQKAeSVGRIMpHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQK 503
Cdd:PRK08276 289 I----IHEYYASSEGGGVTVIT-SEDWLAHPG-SVGKAV-LGEVRILD-EDGNELPPGEIGTVYFEMDGYPFEYHNDPEK 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 504 TEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRL 583
Cdd:PRK08276 361 TAAARNPHGWVTVGDVGYLDEDGYLYLTDRKSDMIISGGVNIYPQEIENLLVTHPKVADVAVFGVPDEEMGERVKAVVQP 440
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 572872742 584 KDGEETTVE---EIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK08276 441 ADGADAGDAlaaELIAWLRGRLAHYKCPRSIDFEDELPRTPTGKLYKRRLRDR 493
|
|
| PRK09088 |
PRK09088 |
acyl-CoA synthetase; Validated |
107-634 |
4.13e-67 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 181644 [Multi-domain] Cd Length: 488 Bit Score: 227.38 E-value: 4.13e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 107 AQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAM 186
Cdd:PRK09088 5 ARLQPQRLAAVDLALGRRWTYAELDALVGRLAAVLRRRGCVDGERLAVLARNSVWLVALHFACARVGAIYVPLNWRLSAS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 187 ELEYVLKKVGCKALVfpkqfktqqyynvlkqicpevENAQPGALKSQRLpDLTTVI-SVDAPLPgtlllDEVVAAGSTRQ 265
Cdd:PRK09088 85 ELDALLQDAEPRLLL---------------------GDDAVAAGRTDVE-DLAAFIaSADALEP-----ADTPSIPPERV 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 266 HLdqlqynqqflschdpinIQFTSGTTGSPKGATLSHYNI---VNNSNILGerlklheKTPEQLRMILPNPLYHCLGSVA 342
Cdd:PRK09088 138 SL-----------------ILFTSGTSGQPKGVMLSERNLqqtAHNFGVLG-------RVDAHSSFLCDAPMFHIIGLIT 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 343 GTMMCLMYGATlILASPIFNGKKALEAISRER--GTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAI 420
Cdd:PRK09088 194 SVRPVLAVGGS-ILVSNGFEPKRTLGRLGDPAlgITHYFCVPQMAQAFRAQPGFDAAALRHLTALFTGGAPHAAEDILGW 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 421 INK-INMKDlvvAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWG 499
Cdd:PRK09088 273 LDDgIPMVD---GFGMSEAGTVFGMSVDCDVIRAKAGAAGIPTPTVQTRVVD-DQGNDCPAGVPGELLLRGPNLSPGYWR 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 500 EPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICA 579
Cdd:PRK09088 349 RPQATARAFTGDGWFRTGDIARRDADGFFWVVDRKKDMFISGGENVYPAEIEAVLADHPGIRECAVVGMADAQWGEVGYL 428
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 572872742 580 CIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQM 634
Cdd:PRK09088 429 AIVPADGAPLDLERIRSHLSTRLAKYKVPKHLRLVDALPRTASGKLQKARLRDAL 483
|
|
| PRK12406 |
PRK12406 |
long-chain-fatty-acid--CoA ligase; Provisional |
122-633 |
2.32e-66 |
|
long-chain-fatty-acid--CoA ligase; Provisional
Pssm-ID: 183506 [Multi-domain] Cd Length: 509 Bit Score: 226.12 E-value: 2.32e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 122 DVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALV 201
Cdd:PRK12406 9 DRRRSFDELAQRAARAAGGLAALGVRPGDCVALLMRNDFAFFEAAYAAMRLGAYAVPVNWHFKPEEIAYILEDSGARVLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 202 FPKQFkTQQYYNVLKQICPEVENAQPGALKSQ-RLPDlttviSVDAPLPGTLLLDEVVAAGSTrqhLDQLQYNQqflsch 280
Cdd:PRK12406 89 AHADL-LHGLASALPAGVTVLSVPTPPEIAAAyRISP-----ALLTPPAGAIDWEGWLAQQEP---YDGPPVPQ------ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 281 dPINIQFTSGTTGSPKGatlshyniVNNSNILGERLKLHEKT-------PEQLRMILPNPLYHCLGSVAGtMMCLMYGAT 353
Cdd:PRK12406 154 -PQSMIYTSGTTGHPKG--------VRRAAPTPEQAAAAEQMraliyglKPGIRALLTGPLYHSAPNAYG-LRAGRLGGV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 354 LILaSPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDF--SSYDISTMCGGVIAGSPAPPELIRAIIN----KINMk 427
Cdd:PRK12406 224 LVL-QPRFDPEELLQLIERHRITHMHMVPTMFIRLLKLPEEvrAKYDVSSLRHVIHAAAPCPADVKRAMIEwwgpVIYE- 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 428 dlvvAYGTTENSPVTFAHfPEDTVeQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELcirgYCVMLG-----YWGEPQ 502
Cdd:PRK12406 302 ----YYGSTESGAVTFAT-SEDAL-SHPGTVGKAAPGAELRFVD-EDGRPLPQGEIGEI----YSRIAGnpdftYHNKPE 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 503 KTEEaVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIR 582
Cdd:PRK12406 371 KRAE-IDRGGFITSGDVGYLDADGYLFLCDRKRDMVISGGVNIYPAEIEAVLHAVPGVHDCAVFGIPDAEFGEALMAVVE 449
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 572872742 583 LKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK12406 450 PQPGATLDEADIRAQLKARLAGYKVPKHIEIMAELPREDSGKIFKRRLRDP 500
|
|
| caiC |
PRK08008 |
putative crotonobetaine/carnitine-CoA ligase; Validated |
96-631 |
1.51e-65 |
|
putative crotonobetaine/carnitine-CoA ligase; Validated
Pssm-ID: 181195 [Multi-domain] Cd Length: 517 Bit Score: 224.18 E-value: 1.51e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 96 SKTVGQCLETTAQRVPEREALVV--LHEDVR-LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA 172
Cdd:PRK08008 6 GQHLRQMWDDLADVYGHKTALIFesSGGVVRrYSYLELNEEINRTANLFYSLGIRKGDKVALHLDNCPEFIFCWFGLAKI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 173 GIILVSVNPAYQAMELEYVLKKVGCKALVFPKQFktqqyYNVLKQICPEVenaqpgalksqrlpdlttvisvDAPLPGTL 252
Cdd:PRK08008 86 GAIMVPINARLLREESAWILQNSQASLLVTSAQF-----YPMYRQIQQED----------------------ATPLRHIC 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 253 LLDEVVAAGSTRQHLDQLQyNQQF--------LSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpe 324
Cdd:PRK08008 139 LTRVALPADDGVSSFTQLK-AQQPatlcyappLSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQCALRDDD-- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 325 qlRMILPNPLYHCLGSVAGTMMCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPdfssydistmcg 404
Cdd:PRK08008 216 --VYLTVMPAFHIDCQCTAAMAAFSAGATFVLLEK-YSARAFWGQVCKYRATITECIPMMIRTLMVQP------------ 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 405 gviagsPAPPE---LIRAIINKINMKD-------------LVVAYGTTENSPVTFAHFPEDtvEQKAESVGRIMPHTEAR 468
Cdd:PRK08008 281 ------PSANDrqhCLREVMFYLNLSDqekdafeerfgvrLLTSYGMTETIVGIIGDRPGD--KRRWPSIGRPGFCYEAE 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 469 IMNmEAGTLAKLNTPGELCIRGY---CVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENI 545
Cdd:PRK08008 353 IRD-DHNRPLPAGEIGEICIKGVpgkTIFKEYYLDPKATAKVLEADGWLHTGDTGYVDEEGFFYFVDRRCNMIKRGGENV 431
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 546 YPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:PRK08008 432 SCVELENIIATHPKIQDIVVVGIKDSIRDEAIKAFVVLNEGETLSEEEFFAFCEQNMAKFKVPSYLEIRKDLPRNCSGKI 511
|
....*.
gi 572872742 626 QKFKLR 631
Cdd:PRK08008 512 IKKNLK 517
|
|
| PRK07786 |
PRK07786 |
long-chain-fatty-acid--CoA ligase; Validated |
103-633 |
1.35e-64 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 169098 [Multi-domain] Cd Length: 542 Bit Score: 222.35 E-value: 1.35e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVVLHEDvrLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:PRK07786 23 LARHALMQPDAPALRFLGNT--TTWRELDDRVAALAGALSRRGVGFGDRVLILMLNRTEFVESVLAANMLGAIAVPVNFR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKALVfpkqfkTQqyyNVLKQICPEVENAQPGalksqrlpdLTTVISV-DAPLPGTLLLDEVVA-A 260
Cdd:PRK07786 101 LTPPEIAFLVSDCGAHVVV------TE---AALAPVATAVRDIVPL---------LSTVVVAgGSSDDSVLGYEDLLAeA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 261 GSTRQHLDqlqynqqfLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNS--NILGERLKLHEKTPeqlrmILPNPLYHC- 337
Cdd:PRK07786 163 GPAHAPVD--------IPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAmtCLRTNGADINSDVG-----FVGVPLFHIa 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 338 -LGSVAGTmmcLMYGATLILaSPI--FNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMcggVIA--GSPA 412
Cdd:PRK07786 230 gIGSMLPG---LLLGAPTVI-YPLgaFDPGQLLDVLEAEKVTGIFLVPAQWQAVCAEQQARPRDLALR---VLSwgAAPA 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 413 PPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVeQKAESVGRIMPHTEARIMNMEAGTLAkLNTPGELCIRGYC 492
Cdd:PRK07786 303 SDTLLRQMAATFPEAQILAAFGQTEMSPVTCMLLGEDAI-RKLGSVGKVIPTVAARVVDENMNDVP-VGEVGEIVYRAPT 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 493 VMLGYWGEPQKTEEAVDqDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDR 572
Cdd:PRK07786 381 LMSGYWNNPEATAEAFA-GGWFHSGDLVRQDEEGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRADEK 459
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 572872742 573 MGEEICACIRLKDG-EETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK07786 460 WGEVPVAVAAVRNDdAALTLEDLAEFLTDRLARYKHPKALEIVDALPRNPAGKVLKTELRER 521
|
|
| PRK03640 |
PRK03640 |
o-succinylbenzoate--CoA ligase; |
107-636 |
2.31e-64 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 235146 [Multi-domain] Cd Length: 483 Bit Score: 219.83 E-value: 2.31e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 107 AQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAM 186
Cdd:PRK03640 12 AFLTPDRTAIE--FEEKKVTFMELHEAVVSVAGKLAALGVKKGDRVALLMKNGMEMILVIHALQQLGAVAVLLNTRLSRE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 187 ELEYVLKKVGCKALVFPKQFKTQQYynvlkqicpevenaqpgALKSQRLPDLTTVISVDAPLPGTLLLDEVVAagstrqh 266
Cdd:PRK03640 90 ELLWQLDDAEVKCLITDDDFEAKLI-----------------PGISVKFAELMNGPKEEAEIQEEFDLDEVAT------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 267 ldqlqynqqflschdpinIQFTSGTTGSPKGATLSHYN----IVNNSNILGerlkLHEKTpeqlRMILPNPLYHCLG-SV 341
Cdd:PRK03640 146 ------------------IMYTSGTTGKPKGVIQTYGNhwwsAVGSALNLG----LTEDD----CWLAAVPIFHISGlSI 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 342 AgtMMCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSY--DISTMCGGviaGSPAPPELIRa 419
Cdd:PRK03640 200 L--MRSVIYGMRVVLVEK-FDAEKINKLLQTGGVTIISVVSTMLQRLLERLGEGTYpsSFRCMLLG---GGPAPKPLLE- 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 420 iinKINMKDLVV--AYGTTENSP--VTFAhfPEDTVEqKAESVGRIMPHTEARIMnmEAGTLAKLNTPGELCIRGYCVML 495
Cdd:PRK03640 273 ---QCKEKGIPVyqSYGMTETASqiVTLS--PEDALT-KLGSAGKPLFPCELKIE--KDGVVVPPFEEGEIVVKGPNVTK 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 496 GYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGE 575
Cdd:PRK03640 345 GYLNREDATRETF-QDGWFKTGDIGYLDEEGFLYVLDRRSDLIISGGENIYPAEIEEVLLSHPGVAEAGVVGVPDDKWGQ 423
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572872742 576 EICACIRLkdGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMER 636
Cdd:PRK03640 424 VPVAFVVK--SGEVTEEELRHFCEEKLAKYKVPKRFYFVEELPRNASGKLLRHELKQLVEE 482
|
|
| PRK07470 |
PRK07470 |
acyl-CoA synthetase; Validated |
100-636 |
2.70e-64 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 180988 [Multi-domain] Cd Length: 528 Bit Score: 221.07 E-value: 2.70e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 100 GQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSV 179
Cdd:PRK07470 10 AHFLRQAARRFPDRIALV--WGDRSWTWREIDARVDALAAALAARGVRKGDRILVHSRNCNQMFESMFAAFRLGAVWVPT 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 180 NPAYQAMELEYVLKKVGCKALVFPKQFktqqyynvlkqicPE-VENAQPGAlksqrlPDLTTVISVDAPlPGTLLLDEVV 258
Cdd:PRK07470 88 NFRQTPDEVAYLAEASGARAMICHADF-------------PEhAAAVRAAS------PDLTHVVAIGGA-RAGLDYEALV 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 259 AAGSTRQHLD-QLQYNqqflschDPINIQFTSGTTGSPKGATLSHYN---IVNNSniLGErlkLHEKTPEQLRMILPNPL 334
Cdd:PRK07470 148 ARHLGARVANaAVDHD-------DPCWFFFTSGTTGRPKAAVLTHGQmafVITNH--LAD---LMPGTTEQDASLVVAPL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 335 YHclGsvAGT--MMCLMYGA-TLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSP 411
Cdd:PRK07470 216 SH--G--AGIhqLCQVARGAaTVLLPSERFDPAEVWALVERHRVTNLFTVPTILKMLVEHPAVDRYDHSSLRYVIYAGAP 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 412 ---APPELIRAIINKInmkdLVVAYGTTEnspVT--------FAHFPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKL 480
Cdd:PRK07470 292 myrADQKRALAKLGKV----LVQYFGLGE---VTgnitvlppALHDAEDGPDARIGTCGFERTGMEVQIQD-DEGRELPP 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 481 NTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKV 560
Cdd:PRK07470 364 GETGEICVIGPAVFAGYYNNPEANAKAF-RDGWFRTGDLGHLDARGFLYITGRASDMYISGGSNVYPREIEEKLLTHPAV 442
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572872742 561 QEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMER 636
Cdd:PRK07470 443 SEVAVLGVPDPVWGEVGVAVCVARDGAPVDEAELLAWLDGKVARYKLPKRFFFWDALPKSGYGKITKKMVREELEE 518
|
|
| VL_LC_FACS_like |
cd05907 |
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ... |
125-572 |
3.22e-64 |
|
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341233 [Multi-domain] Cd Length: 452 Bit Score: 218.62 E-value: 3.22e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 125 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVfpk 204
Cdd:cd05907 6 ITWAEFAEEVRALAKGLIALGVEPGDRVAILSRNRPEWTIADLAILAIGAVPVPIYPTSSAEQIAYILNDSEAKALF--- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 205 qfktqqyynvlkqicpeVENAQpgalksqrlpDLTTVIsvdaplpgtllldevvaagstrqhldqlqynqqflschdpin 284
Cdd:cd05907 83 -----------------VEDPD----------DLATII------------------------------------------ 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 285 iqFTSGTTGSPKGATLSHYNIVNNSNILGERLklhEKTPEQlRMILPNPLYHCLGSVAGTMMCLMYGATLILASPIfngK 364
Cdd:cd05907 94 --YTSGTTGRPKGVMLSHRNILSNALALAERL---PATEGD-RHLSFLPLAHVFERRAGLYVPLLAGARIYFASSA---E 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 365 KALEAISRERGTFLYGTPTMFvdilnQPDFSSYDISTMCGG----------------VIAGSPAPPELIRaIINKINMkD 428
Cdd:cd05907 165 TLLDDLSEVRPTVFLAVPRVW-----EKVYAAIKVKAVPGLkrklfdlavggrlrfaASGGAPLPAELLH-FFRALGI-P 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 429 LVVAYGTTENSPVTFAHFPEDtveQKAESVGRIMPHTEARIMNmeagtlaklntPGELCIRGYCVMLGYWGEPQKTEEAV 508
Cdd:cd05907 238 VYEGYGLTETSAVVTLNPPGD---NRIGTVGKPLPGVEVRIAD-----------DGEILVRGPNVMLGYYKNPEATAEAL 303
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572872742 509 DQDKWYWTGDVATMNEQGFCKIVGRSKDMII-RGGENIYPAELEDFFHTHPKVQEVQVVGvkDDR 572
Cdd:cd05907 304 DADGWLHTGDLGEIDEDGFLHITGRKKDLIItSGGKNISPEPIENALKASPLISQAVVIG--DGR 366
|
|
| OSB_CoA_lg |
cd05912 |
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ... |
125-632 |
1.32e-63 |
|
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); O-succinylbenzoic acid-CoA synthase catalyzes the coenzyme A (CoA)- and ATP-dependent conversion of o-succinylbenzoic acid to o-succinylbenzoyl-CoA. The reaction is the fourth step of the biosynthesis pathway of menaquinone (vitamin K2). In certain bacteria, menaquinone is used during fumarate reduction in anaerobic respiration. In cyanobacteria, the product of the menaquinone pathway is phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone), a molecule used exclusively as an electron transfer cofactor in Photosystem 1. In green sulfur bacteria and heliobacteria, menaquinones are used as loosely bound secondary electron acceptors in the photosynthetic reaction center.
Pssm-ID: 341238 [Multi-domain] Cd Length: 411 Bit Score: 215.67 E-value: 1.32e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 125 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKalvfpk 204
Cdd:cd05912 2 YTFAELFEEVSRLAEHLAALGVRKGDRVALLSKNSIEMILLIHALWLLGAEAVLLNTRLTPNELAFQLKDSDVK------ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 205 qfktqqyynvlkqicpevenaqpgalksqrlpdlttvisvdaplpgtllLDEVVAagstrqhldqlqynqqflschdpin 284
Cdd:cd05912 76 -------------------------------------------------LDDIAT------------------------- 81
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 285 IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLG-SVagTMMCLMYGATLILAsPIFNG 363
Cdd:cd05912 82 IMYTSGTTGKPKGVQQTFGNHWWSAIGSALNLGLTEDD----NWLCALPLFHISGlSI--LMRSVIYGMTVYLV-DKFDA 154
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 364 KKALEAISRERGTFLYGTPTMFVDILNQ-PDFSSYDISTMCGGviaGSPAPPELIRaiinKINMKDLVV--AYGTTENSP 440
Cdd:cd05912 155 EQVLHLINSGKVTIISVVPTMLQRLLEIlGEGYPNNLRCILLG---GGPAPKPLLE----QCKEKGIPVyqSYGMTETCS 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 441 --VTFAhfPEDTVEqKAESVGRIMPHTEARIMNmeagTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGD 518
Cdd:cd05912 228 qiVTLS--PEDALN-KIGSAGKPLFPVELKIED----DGQPPYEVGEILLKGPNVTKGYLNRPDATEESF-ENGWFKTGD 299
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 519 VATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKdgEETTVEEIKAFC 598
Cdd:cd05912 300 IGYLDEEGFLYVLDRRSDLIISGGENIYPAEIEEVLLSHPAIKEAGVVGIPDDKWGQVPVAFVVSE--RPISEEELIAYC 377
|
490 500 510
....*....|....*....|....*....|....
gi 572872742 599 KGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:cd05912 378 SEKLAKYKVPKKIYFVDELPRTASGKLLRHELKQ 411
|
|
| BCL_4HBCL |
cd05959 |
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ... |
124-631 |
2.06e-62 |
|
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate CoA ligase and 4-hydroxybenzoate-coenzyme A ligase catalyze the first activating step for benzoate and 4-hydroxybenzoate catabolic pathways, respectively. Although these two enzymes share very high sequence homology, they have their own substrate preference. The reaction proceeds via a two-step process; the first ATP-dependent step forms the substrate-AMP intermediate, while the second step forms the acyl-CoA ester, releasing the AMP. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Some bacteria can use benzoic acid or benzenoid compounds as the sole source of carbon and energy through degradation. Benzoate CoA ligase and 4-hydroxybenzoate-Coenzyme A ligase are key enzymes of this process.
Pssm-ID: 341269 [Multi-domain] Cd Length: 508 Bit Score: 215.31 E-value: 2.06e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 124 RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVfp 203
Cdd:cd05959 29 SLTYAELEAEARRVAGALRALGVKREERVLLIMLDTVDFPTAFLGAIRAGIVPVPVNTLLTPDDYAYYLEDSRARVVV-- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 204 kqfktqqyynVLKQICPEVENAQPGALksqrlPDLTTVISVDA--PLPGTLLLDEVVAAGSTrqhldqlQYNQQFLSCHD 281
Cdd:cd05959 107 ----------VSGELAPVLAAALTKSE-----HTLVVLIVSGGagPEAGALLLAELVAAEAE-------QLKPAATHADD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 282 PINIQFTSGTTGSPKGATLSHYNIVNNSNILGER-LKLHEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGATLILASPI 360
Cdd:cd05959 165 PAFWLYSSGSTGRPKGVVHLHADIYWTAELYARNvLGIREDD----VCFSAAKLFFAYGLGNSLTFPLSVGATTVLMPER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 361 FNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMkDLVVAYGTTENSP 440
Cdd:cd05959 241 PTPAAVFKRIRRYRPTVFFGVPTLYAAMLAAPNLPSRDLSSLRLCVSAGEALPAEVGERWKARFGL-DILDGIGSTEMLH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 441 VTFAHFPEDTveqKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEeAVDQDKWYWTGDVA 520
Cdd:cd05959 320 IFLSNRPGRV---RYGTTGKPVPGYEVELRD-EDGGDVADGEPGELYVRGPSSATMYWNNRDKTR-DTFQGEWTRTGDKY 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 521 TMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETT---VEEIKAF 597
Cdd:cd05959 395 VRDDDGFYTYAGRADDMLKVSGIWVSPFEVESALVQHPAVLEAAVVGVEDEDGLTKPKAFVVLRPGYEDSealEEELKEF 474
|
490 500 510
....*....|....*....|....*....|....
gi 572872742 598 CKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05959 475 VKDRLAPYKYPRWIVFVDELPKTATGKIQRFKLR 508
|
|
| PRK06178 |
PRK06178 |
acyl-CoA synthetase; Validated |
97-636 |
2.28e-62 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235724 [Multi-domain] Cd Length: 567 Bit Score: 216.83 E-value: 2.28e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 97 KTVGQCLETTAQRVPEREALVVLHEdvRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIIL 176
Cdd:PRK06178 33 RPLTEYLRAWARERPQRPAIIFYGH--VITYAELDELSDRFAALLRQRGVGAGDRVAVFLPNCPQFHIVFFGILKLGAVH 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 177 VSVNPAYQAMELEYVLKKVGCKALVFPKQFktqqyYNVLKQICPE--VENAQPGALkSQRLPDLTTVisvdaPLPGTLLL 254
Cdd:PRK06178 111 VPVSPLFREHELSYELNDAGAEVLLALDQL-----APVVEQVRAEtsLRHVIVTSL-ADVLPAEPTL-----PLPDSLRA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 255 DEVVAAGSTR--QHLDQL--QYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNN--SNILgerLKLHEKTPEQLRM 328
Cdd:PRK06178 180 PRLAAAGAIDllPALRACtaPVPLPPPALDALAALNYTGGTTGMPKGCEHTQRDMVYTaaAAYA---VAVVGGEDSVFLS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 329 ILPnpLYHCLGSVAGTMMCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMcggvia 408
Cdd:PRK06178 257 FLP--EFWIAGENFGLLFPLFSGATLVLLAR-WDAVAFMAAVERYRVTRTVMLVDNAVELMDHPRFAEYDLSSL------ 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 409 gspappELIRAI--INKINM------KDLV------VAYGTTE-NSPVTF-AHFPEDTVEQKAES--VGRIMPHTEARIM 470
Cdd:PRK06178 328 ------RQVRVVsfVKKLNPdyrqrwRALTgsvlaeAAWGMTEtHTCDTFtAGFQDDDFDLLSQPvfVGLPVPGTEFKIC 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 471 NMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAEL 550
Cdd:PRK06178 402 DFETGELLPLGAEGEIVVRTPSLLKGYWNKPEATAEAL-RDGWLHTGDIGKIDEQGFLHYLGRRKEMLKVNGMSVFPSEV 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 551 EDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKyIVFVTNYPLTISGKIQKFKL 630
Cdd:PRK06178 481 EALLGQHPAVLGSAVVGRPDPDKGQVPVAFVQLKPGADLTAAALQAWCRENMAVYKVPE-IRIVDALPMTATGKVRKQDL 559
|
....*.
gi 572872742 631 REQMER 636
Cdd:PRK06178 560 QALAEE 565
|
|
| PRK05677 |
PRK05677 |
long-chain-fatty-acid--CoA ligase; Validated |
97-633 |
3.49e-62 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 168170 [Multi-domain] Cd Length: 562 Bit Score: 216.17 E-value: 3.49e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 97 KTVGQCLETTAQRVPEREALVVLheDVRLTFAQLkEEVDKAASGLLS--IGLCKGDRLGMWGPNSYAWVLMQLATAQAGI 174
Cdd:PRK05677 24 PNIQAVLKQSCQRFADKPAFSNL--GKTLTYGEL-YKLSGAFAAWLQqhTDLKPGDRIAVQLPNVLQYPVAVFGAMRAGL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 175 ILVSVNPAYQAMELEYVLKKVGCKAL------------VFPKqfkTQqyynVLKQICPEVENAQPgALKSQRLPDLTTVI 242
Cdd:PRK05677 101 IVVNTNPLYTAREMEHQFNDSGAKALvclanmahlaekVLPK---TG----VKHVIVTEVADMLP-PLKRLLINAVVKHV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 243 SVDAP---LPGTLLLDEVVAAGSTRQHLDqlqynqqfLSCH--DPINIQFTSGTTGSPKGATLSHYNIVnnSNILGERLK 317
Cdd:PRK05677 173 KKMVPayhLPQAVKFNDALAKGAGQPVTE--------ANPQadDVAVLQYTGGTTGVAKGAMLTHRNLV--ANMLQCRAL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 318 LHEKTPEQLR-MILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSS 396
Cdd:PRK05677 243 MGSNLNEGCEiLIAPLPLYHIYAFTFHCMAMMLIGNHNILISNPRDLPAMVKELGKWKFSGFVGLNTLFVALCNNEAFRK 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 397 YDIS----TMCGGvIAGSPAPPELIRAIINKinmkDLVVAYGTTENSPVTFAHFPEDTveqKAESVGRIMPHTEARIMNm 472
Cdd:PRK05677 323 LDFSalklTLSGG-MALQLATAERWKEVTGC----AICEGYGMTETSPVVSVNPSQAI---QVGTIGIPVPSTLCKVID- 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 473 EAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELED 552
Cdd:PRK05677 394 DDGNELPLGEVGELCVKGPQVMKGYWQRPEATDEILDSDGWLKTGDIALIQEDGYMRIVDRKKDMILVSGFNVYPNELED 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 553 FFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:PRK05677 474 VLAALPGVLQCAAIGVPDEKSGEAIKVFVVVKPGETLTKEQVMEHMRANLTGYKVPKAVEFRDELPTTNVGKILRRELRD 553
|
.
gi 572872742 633 Q 633
Cdd:PRK05677 554 E 554
|
|
| PLN02860 |
PLN02860 |
o-succinylbenzoate-CoA ligase |
99-638 |
4.78e-62 |
|
o-succinylbenzoate-CoA ligase
Pssm-ID: 215464 [Multi-domain] Cd Length: 563 Bit Score: 215.82 E-value: 4.78e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 99 VGQCLETTAQRvpEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILV- 177
Cdd:PLN02860 9 ICQCLTRLATL--RGNAVVTISGNRRRTGHEFVDGVLSLAAGLLRLGLRNGDVVAIAALNSDLYLEWLLAVACAGGIVAp 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 178 -----SVNPAYQAMELeyvlkkVGCKALVFPKQfktqqyynvLKQICPEVENAQPGALKSQRLPDLTTVISVDApLPGTL 252
Cdd:PLN02860 87 lnyrwSFEEAKSAMLL------VRPVMLVTDET---------CSSWYEELQNDRLPSLMWQVFLESPSSSVFIF-LNSFL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 253 LLDEVVAAGSTRQHLDQlqynqqflsCHDPIN---IQFTSGTTGSPKGATLSHYNIVNNS----NILG---ERLKLHEKt 322
Cdd:PLN02860 151 TTEMLKQRALGTTELDY---------AWAPDDavlICFTSGTTGRPKGVTISHSALIVQSlakiAIVGygeDDVYLHTA- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 323 peqlrmilpnPLYHcLGSVAGTMMCLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDIL-----NQPDFSSY 397
Cdd:PLN02860 221 ----------PLCH-IGGLSSALAMLMVGACHVLL-PKFDAKAALQAIKQHNVTSMITVPAMMADLIsltrkSMTWKVFP 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 398 DISTMCGGviaGSPAPPELIRAIINKINMKDLVVAYGTTEN-SPVTFAHFPEDTVEQKAES------------------- 457
Cdd:PLN02860 289 SVRKILNG---GGSLSSRLLPDAKKLFPNAKLFSAYGMTEAcSSLTFMTLHDPTLESPKQTlqtvnqtksssvhqpqgvc 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 458 VGRIMPHTEARIMNMEAGTLAKLNTpgelciRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDM 537
Cdd:PLN02860 366 VGKPAPHVELKIGLDESSRVGRILT------RGPHVMLGYWGQNSETASVLSNDGWLDTGDIGWIDKAGNLWLIGRSNDR 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 538 IIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDG------------EETTV--EEIKAFCKGK-I 602
Cdd:PLN02860 440 IKTGGENVYPEEVEAVLSQHPGVASVVVVGVPDSRLTEMVVACVRLRDGwiwsdnekenakKNLTLssETLRHHCREKnL 519
|
570 580 590
....*....|....*....|....*....|....*..
gi 572872742 603 SHFKIPK-YIVFVTNYPLTISGKIQKFKLREQMERHL 638
Cdd:PLN02860 520 SRFKIPKlFVQWRKPFPLTTTGKIRRDEVRREVLSHL 556
|
|
| menE |
TIGR01923 |
O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, ... |
126-630 |
5.99e-62 |
|
O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, which is involved in the fourth step of the menaquinone biosynthesis pathway. O-succinylbenzoate-CoA ligase, together with menB - naphtoate synthase, take 2-succinylbenzoate and convert it into 1,4-di-hydroxy-2- naphtoate. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Pssm-ID: 162605 [Multi-domain] Cd Length: 436 Bit Score: 212.31 E-value: 5.99e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 126 TFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGcKALVFPKQ 205
Cdd:TIGR01923 1 TWQDLDCEAAHLAKALKAQGIRSGSRVALVGQNSIEMVLLLHACLLLGAEIAMLNTRLTENERTNQLEDLD-VQLLLTDS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 206 FKTQQyynvlkqicpevenaqpgalksqrlpDLTTVIsvdaplpgtllLDEVVAAGstrqhLDQLQYNQQFlSCHDPINI 285
Cdd:TIGR01923 80 LLEEK--------------------------DFQADS-----------LDRIEAAG-----RYETSLSASF-NMDQIATL 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 286 QFTSGTTGSPKGATLSHYNIVNNSniLGERLKLHekTPEQLRMILPNPLYHcLGSVAGTMMCLMYGATLILASPiFNgkK 365
Cdd:TIGR01923 117 MFTSGTTGKPKAVPHTFRNHYASA--VGSKENLG--FTEDDNWLLSLPLYH-ISGLSILFRWLIEGATLRIVDK-FN--Q 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 366 ALEAISRERGTFLYGTPTMFVDILNQpDFSSYDISTMCGGviaGSPAPPELIR-AIINKInmkDLVVAYGTTENSPVTFA 444
Cdd:TIGR01923 189 LLEMIANERVTHISLVPTQLNRLLDE-GGHNENLRKILLG---GSAIPAPLIEeAQQYGL---PIYLSYGMTETCSQVTT 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 445 HFPEDTVEQKaeSVGRIMPHTEARIMNmeagtlAKLNTPGELCIRGYCVMLGYWGEPQKTEeAVDQDKWYWTGDVATMNE 524
Cdd:TIGR01923 262 ATPEMLHARP--DVGRPLAGREIKIKV------DNKEGHGEIMVKGANLMKGYLYQGELTP-AFEQQGWFNTGDIGELDG 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 525 QGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKdgEETTVEEIKAFCKGKISH 604
Cdd:TIGR01923 333 EGFLYVLGRRDDLIISGGENIYPEEIETVLYQHPGIQEAVVVPKPDAEWGQVPVAYIVSE--SDISQAKLIAYLTEKLAK 410
|
490 500
....*....|....*....|....*.
gi 572872742 605 FKIPKYIVFVTNYPLTISGKIQKFKL 630
Cdd:TIGR01923 411 YKVPIAFEKLDELPYNASGKILRNQL 436
|
|
| PRK13391 |
PRK13391 |
acyl-CoA synthetase; Provisional |
107-633 |
1.63e-60 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 184022 [Multi-domain] Cd Length: 511 Bit Score: 210.32 E-value: 1.63e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 107 AQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAM 186
Cdd:PRK13391 7 AQTTPDKPAVIMASTGEVVTYRELDERSNRLAHLFRSLGLKRGDHVAIFMENNLRYLEVCWAAERSGLYYTCVNSHLTPA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 187 ELEYVLKKVGCKALVfpkqfKTQQYYNVlkqiCPEVenaqpgalkSQRLPDLTTVISVDAP--LPGTLLLDEVVAAGSTR 264
Cdd:PRK13391 87 EAAYIVDDSGARALI-----TSAAKLDV----ARAL---------LKQCPGVRHRLVLDGDgeLEGFVGYAEAVAGLPAT 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 265 QHLDQlqynqqflSCHDPIniQFTSGTTGSPKG--ATLSHYNIVNNSNILGERLKLHEKTPEqLRMILPNPLYHClGSVA 342
Cdd:PRK13391 149 PIADE--------SLGTDM--LYSSGTTGRPKGikRPLPEQPPDTPLPLTAFLQRLWGFRSD-MVYLSPAPLYHS-APQR 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 343 GTMMCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPD--FSSYDISTMCGGVIAGSPAPPELIRAI 420
Cdd:PRK13391 217 AVMLVIRLGGTVIVMEH-FDAEQYLALIEEYGVTHTQLVPTMFSRMLKLPEevRDKYDLSSLEVAIHAAAPCPPQVKEQM 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 421 INKINMkdlVVA--YGTTENSPVTFAHfPEDTVEQKAeSVGRIM---PHtearIMNmEAGTLAKLNTPGELCIRGyCVML 495
Cdd:PRK13391 296 IDWWGP---IIHeyYAATEGLGFTACD-SEEWLAHPG-TVGRAMfgdLH----ILD-DDGAELPPGEPGTIWFEG-GRPF 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 496 GYWGEPQKTEEAVDQDK-WYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMG 574
Cdd:PRK13391 365 EYLNDPAKTAEARHPDGtWSTVGDIGYVDEDGYLYLTDRAAFMIISGGVNIYPQEAENLLITHPKVADAAVFGVPNEDLG 444
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 572872742 575 EEICACIRLKDGEETTV---EEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK13391 445 EEVKAVVQPVDGVDPGPalaAELIAFCRQRLSRQKCPRSIDFEDELPRLPTGKLYKRLLRDR 506
|
|
| PRK06164 |
PRK06164 |
acyl-CoA synthetase; Validated |
103-638 |
1.65e-60 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235722 [Multi-domain] Cd Length: 540 Bit Score: 211.14 E-value: 1.65e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALvvLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:PRK06164 16 LDAHARARPDAVAL--IDEDRPLSRAELRALVDRLAAWLAAQGVRRGDRVAVWLPNCIEWVVLFLACARLGATVIAVNTR 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVenaqpgalksqrLPDLTTVISVD---APLPGTLLLDEVVA 259
Cdd:PRK06164 94 YRSHEVAHILGRGRARWLVVWPGFKGIDFAAILAAVPPDA------------LPPLRAIAVVDdaaDATPAPAPGARVQL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 260 AGSTRQHLDQLQYNQQflSCHDPINIQFT-SGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCL 338
Cdd:PRK06164 162 FALPDPAPPAAAGERA--ADPDAGALLFTtSGTTSGPKLVLHRQATLLRHARAIARAYGYDPGA----VLLAALPFCGVF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 339 GsVAGTMMCLMYGATLILaSPIFNGKKALEAISRERGTFLYGTPTMFVDILNQ----PDFSSYDIStmcgGVIAGSPAPP 414
Cdd:PRK06164 236 G-FSTLLGALAGGAPLVC-EPVFDAARTARALRRHRVTHTFGNDEMLRRILDTagerADFPSARLF----GFASFAPALG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 415 ELIRaiinKINMKDLVVA--YGTTENSPVTFAHFPEDTVEQKAESVGRIM-PHTEARIMNMEAGTLAKLNTPGELCIRGY 491
Cdd:PRK06164 310 ELAA----LARARGVPLTglYGSSEVQALVALQPATDPVSVRIEGGGRPAsPEARVRARDPQDGALLPDGESGEIEIRAP 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 492 CVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVkdD 571
Cdd:PRK06164 386 SLMRGYLDNPDATARALTDDGYFRTGDLGYTRGDGQFVYQTRMGDSLRLGGFLVNPAEIEHALEALPGVAAAQVVGA--T 463
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572872742 572 RMGEEIC-ACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISG---KIQKFKLREQMERHL 638
Cdd:PRK06164 464 RDGKTVPvAFVIPTDGASPDEAGLMAACREALAGFKVPARVQVVEAFPVTESAngaKIQKHRLREMAQARL 534
|
|
| PRK07788 |
PRK07788 |
acyl-CoA synthetase; Validated |
107-632 |
2.04e-60 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236097 [Multi-domain] Cd Length: 549 Bit Score: 210.94 E-value: 2.04e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 107 AQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAM 186
Cdd:PRK07788 59 ARRAPDRAALI--DERGTLTYAELDEQSNALARGLLALGVRAGDGVAVLARNHRGFVLALYAAGKVGARIILLNTGFSGP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 187 ELEYVLKKVGCKALVFPKQFKTqqyynVLKQICPEVenaqPGALKSQRLPDlttviSVDAPLPGTLLLDEVVAAGSTRqh 266
Cdd:PRK07788 137 QLAEVAAREGVKALVYDDEFTD-----LLSALPPDL----GRLRAWGGNPD-----DDEPSGSTDETLDDLIAGSSTA-- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 267 ldqlqyNQQFLSCHDPINIQfTSGTTGSPKGATLSHYNIVNNSNILGERLKLhektPEQLRMILPNPLYHCLGSVAGTmM 346
Cdd:PRK07788 201 ------PLPKPPKPGGIVIL-TSGTTGTPKGAPRPEPSPLAPLAGLLSRVPF----RAGETTLLPAPMFHATGWAHLT-L 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 347 CLMYGATLILaSPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPD--FSSYDISTMCGGVIAGSPAPPELIRAIINKI 424
Cdd:PRK07788 269 AMALGSTVVL-RRRFDPEATLEDIAKHKATALVVVPVMLSRILDLGPevLAKYDTSSLKIIFVSGSALSPELATRALEAF 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 425 -----NMkdlvvaYGTTENSPVTFAHfPEDTVEQKAeSVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWG 499
Cdd:PRK07788 348 gpvlyNL------YGSTEVAFATIAT-PEDLAEAPG-TVGRPPKGVTVKILD-ENGNEVPRGVVGRIFVGNGFPFEGYTD 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 500 EPQKTEEavdqDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICA 579
Cdd:PRK07788 419 GRDKQII----DGLLSSGDVGYFDEDGLLFVDGRDDDMIVSGGENVFPAEVEDLLAGHPDVVEAAVIGVDDEEFGQRLRA 494
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 572872742 580 CIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:PRK07788 495 FVVKAPGAALDEDAIKDYVRDNLARYKVPRDVVFLDELPRNPTGKVLKRELRE 547
|
|
| CBAL |
cd05923 |
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ... |
97-634 |
6.57e-59 |
|
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) to 4-chlorobenzoyl-coenzyme A (4-CB-CoA) by the two-step adenylation and thioester-forming reactions. 4-Chlorobenzoate (4-CBA) is an environmental pollutant derived from microbial breakdown of aromatic pollutants, such as polychlorinated biphenyls (PCBs), DDT, and certain herbicides. The 4-CBA degrading pathway converts 4-CBA to the metabolite 4-hydroxybezoate (4-HBA), allowing some soil-dwelling microbes to utilize 4-CBA as an alternate carbon source. This pathway consists of three chemical steps catalyzed by 4-CBA-CoA ligase, 4-CBA-CoA dehalogenase, and 4HBA-CoA thioesterase in sequential reactions.
Pssm-ID: 341247 [Multi-domain] Cd Length: 493 Bit Score: 205.44 E-value: 6.57e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 97 KTVGQCLETTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIIL 176
Cdd:cd05923 1 QTVFEMLRRAASRAPDACAIADPARGLRLTYSELRARIEAVAARLHARGLRPGQRVAVVLPNSVEAVIALLALHRLGAVP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 177 VSVNPAYQAMELEYVLKKVGCKALVfpkqfktqqyynvlkqICPEVENAQPGALKSQRLpdlttvisvdaplpgtLLLDE 256
Cdd:cd05923 81 ALINPRLKAAELAELIERGEMTAAV----------------IAVDAQVMDAIFQSGVRV----------------LALSD 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 257 VVAAGSTRQHLDQLQYNQQflSCHDPINIQFTSGTTGSPKGATLSHYNIVNN----SNILGERLKLHEktpeqlRMILPN 332
Cdd:cd05923 129 LVGLGEPESAGPLIEDPPR--EPEQPAFVFYTSGTTGLPKGAVIPQRAAESRvlfmSTQAGLRHGRHN------VVLGLM 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 333 PLYHCLGSVAGTMMCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPA 412
Cdd:cd05923 201 PLYHVIGFFAVLVAALALDGTYVVVEE-FDPADALKLIEQERVTSLFATPTHLDALAAAAEFAGLKLSSLRHVTFAGATM 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 413 PPELIRAIINKI-NMKdlVVAYGTTENSPVTFAHFPedtveqKAESVGRIMPHTEARIMNMEAGT--LAKLNTPGELCIR 489
Cdd:cd05923 280 PDAVLERVNQHLpGEK--VNIYGTTEAMNSLYMRDA------RTGTEMRPGFFSEVRIVRIGGSPdeALANGEEGELIVA 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 490 --GYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVG 567
Cdd:cd05923 352 aaADAAFTGYLNQPEATAKKL-QDGWYRTGDVGYVDPSGDVRILGRVDDMIISGGENIHPSEIERVLSRHPGVTEVVVIG 430
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 572872742 568 VKDDRMGEEICACIRLKDGeETTVEEIKAFCK-GKISHFKIPKYIVFVTNYPLTISGKIqkfkLREQM 634
Cdd:cd05923 431 VADERWGQSVTACVVPREG-TLSADELDQFCRaSELADFKRPRRYFFLDELPKNAMNKV----LRRQL 493
|
|
| MACS_like |
cd05972 |
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ... |
125-631 |
1.08e-58 |
|
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.
Pssm-ID: 341276 [Multi-domain] Cd Length: 428 Bit Score: 203.34 E-value: 1.08e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 125 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVfpk 204
Cdd:cd05972 1 WSFRELKRESAKAANVLAKLGLRKGDRVAVLLPRVPELWAVILAVIKLGAVYVPLTTLLGPKDIEYRLEAAGAKAIV--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 205 qfktqqyynvlkqicpevenaqpgalksqrlpdlttvisVDAplpgtllldevvaagstrqhldqlqynqqflscHDPIN 284
Cdd:cd05972 78 ---------------------------------------TDA---------------------------------EDPAL 85
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 285 IQFTSGTTGSPKGATLSHY----NIVNNSNILGERLK-LHEKTPEqlrmilPNPLYHCLGSVAGTMmcLMYGATLILASP 359
Cdd:cd05972 86 IYFTSGTTGLPKGVLHTHSyplgHIPTAAYWLGLRPDdIHWNIAD------PGWAKGAWSSFFGPW--LLGATVFVYEGP 157
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 360 IFNGKKALEAISRERGTFLYGTPTMFvDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTEnS 439
Cdd:cd05972 158 RFDAERILELLERYGVTSFCGPPTAY-RMLIKQDLSSYKFSHLRLVVSAGEPLNPEVIEWWRAATGLP-IRDGYGQTE-T 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 440 PVTFAHFPedTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCV--MLGYWGEPQKTEEAVDQDkWYWTG 517
Cdd:cd05972 235 GLTVGNFP--DMPVKPGSMGRPTPGYDVAIID-DDGRELPPGEEGDIAIKLPPPglFLGYVGDPEKTEASIRGD-YYLTG 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 518 DVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETT---VEEI 594
Cdd:cd05972 311 DRAYRDEDGYFWFVGRADDIIKSSGYRIGPFEVESALLEHPAVAEAAVVGSPDPVRGEVVKAFVVLTSGYEPSeelAEEL 390
|
490 500 510
....*....|....*....|....*....|....*..
gi 572872742 595 KAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05972 391 QGHVKKVLAPYKYPREIEFVEELPKTISGKIRRVELR 427
|
|
| PLN02330 |
PLN02330 |
4-coumarate--CoA ligase-like 1 |
126-634 |
2.41e-58 |
|
4-coumarate--CoA ligase-like 1
Pssm-ID: 215189 [Multi-domain] Cd Length: 546 Bit Score: 205.21 E-value: 2.41e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 126 TFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVfpkq 205
Cdd:PLN02330 57 TYGEVVRDTRRFAKALRSLGLRKGQVVVVVLPNVAEYGIVALGIMAAGGVFSGANPTALESEIKKQAEAAGAKLIV---- 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 206 fktqqyynvlkqicpeVENAQPGALKSQRLPDLTT-VISVDAPLPGTLLLDEVVAAGSTRQHLDQLQynqqflscHDPIN 284
Cdd:PLN02330 133 ----------------TNDTNYGKVKGLGLPVIVLgEEKIEGAVNWKELLEAADRAGDTSDNEEILQ--------TDLCA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 285 IQFTSGTTGSPKGATLSHYNIVNN--SNILGERlklhektPEQLRMILP---NPLYHCLGsVAGTMMCLMYGATLILASP 359
Cdd:PLN02330 189 LPFSSGTTGISKGVMLTHRNLVANlcSSLFSVG-------PEMIGQVVTlglIPFFHIYG-ITGICCATLRNKGKVVVMS 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 360 IFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVI--AGSPAPPELIRAIINKINMKDLVVAYGTTE 437
Cdd:PLN02330 261 RFELRTFLNALITQEVSFAPIVPPIILNLVKNPIVEEFDLSKLKLQAImtAAAPLAPELLTAFEAKFPGVQVQEAYGLTE 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 438 NSPVTFAHFPEDTVE--QKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYW 515
Cdd:PLN02330 341 HSCITLTHGDPEKGHgiAKKNSVGFILPNLEVKFIDPDTGRSLPKNTPGELCVRSQCVMQGYYNNKEETDRTIDEDGWLH 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 516 TGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIK 595
Cdd:PLN02330 421 TGDIGYIDDDGDIFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVVPLPDEEAGEIPAACVVINPKAKESEEDIL 500
|
490 500 510
....*....|....*....|....*....|....*....
gi 572872742 596 AFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQM 634
Cdd:PLN02330 501 NFVAANVAHYKKVRVVQFVDSIPKSLSGKIMRRLLKEKM 539
|
|
| PRK07798 |
PRK07798 |
acyl-CoA synthetase; Validated |
98-624 |
4.34e-58 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236100 [Multi-domain] Cd Length: 533 Bit Score: 204.35 E-value: 4.34e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 98 TVGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILV 177
Cdd:PRK07798 4 NIADLFEAVADAVPDRVALV--CGDRRLTYAELEERANRLAHYLIAQGLGPGDHVGIYARNRIEYVEAMLGAFKARAVPV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 178 SVNPAYQAMELEYVLKKVGCKALVFPKQFktqqyynvlkqiCPEVENAQPgalksqRLPDLTTVISVD-----APLPGTL 252
Cdd:PRK07798 82 NVNYRYVEDELRYLLDDSDAVALVYEREF------------APRVAEVLP------RLPKLRTLVVVEdgsgnDLLPGAV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 253 LLDEVVAAGSTRQHLDQlqynqqflSCHDPINIQFTSGTTGSPKGATLSHYNI---------------VNNSNILGERLK 317
Cdd:PRK07798 144 DYEDALAAGSPERDFGE--------RSPDDLYLLYTGGTTGMPKGVMWRQEDIfrvllggrdfatgepIEDEEELAKRAA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 318 lheKTPEQLRMILPnPLYHCLGSVAgTMMCLMYGATLILAS-PIFNGKKALEAISRERGTFL------YGTPtmFVDILN 390
Cdd:PRK07798 216 ---AGPGMRRFPAP-PLMHGAGQWA-AFAALFSGQTVVLLPdVRFDADEVWRTIEREKVNVItivgdaMARP--LLDALE 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 391 QPDfsSYDISTMcgGVIAGSPAP--PE----LIRAIINKInmkdLVVAYGTTE---NSPVTFAHFPEDTVEQK------- 454
Cdd:PRK07798 289 ARG--PYDLSSL--FAIASGGALfsPSvkeaLLELLPNVV----LTDSIGSSEtgfGGSGTVAKGAVHTGGPRftigprt 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 455 ---AESVGRIMPHTEARimnmeaGTLAKlntpgelciRGYcVMLGYWGEPQKTEEA---VDQDKWYWTGDVATMNEQGFC 528
Cdd:PRK07798 361 vvlDEDGNPVEPGSGEI------GWIAR---------RGH-IPLGYYKDPEKTAETfptIDGVRYAIPGDRARVEADGTI 424
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 529 KIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIP 608
Cdd:PRK07798 425 TLLGRGSVCINTGGEKVFPEEVEEALKAHPDVADALVVGVPDERWGQEVVAVVQLREGARPDLAELRAHCRSSLAGYKVP 504
|
570
....*....|....*.
gi 572872742 609 KYIVFVTNYPLTISGK 624
Cdd:PRK07798 505 RAIWFVDEVQRSPAGK 520
|
|
| PRK06155 |
PRK06155 |
crotonobetaine/carnitine-CoA ligase; Provisional |
70-633 |
1.86e-57 |
|
crotonobetaine/carnitine-CoA ligase; Provisional
Pssm-ID: 235719 [Multi-domain] Cd Length: 542 Bit Score: 202.68 E-value: 1.86e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 70 REVDRMVSTPIGGLSyvqgctkkhLNSKTVGQCLETTAQRVPEREALVVlhEDVRLTFAQLKEEVDKAASGLLSIGLCKG 149
Cdd:PRK06155 3 PLGAGLAARAVDPLP---------PSERTLPAMLARQAERYPDRPLLVF--GGTRWTYAEAARAAAAAAHALAAAGVKRG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 150 DRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVfpkqfktqqyynVLKQICPEVENAQPGA 229
Cdd:PRK06155 72 DRVALMCGNRIEFLDVFLGCAWLGAIAVPINTALRGPQLEHILRNSGARLLV------------VEAALLAALEAADPGD 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 230 LKSQR--LPDLTTVISVDA-----PLPGtllLDEVVAAGSTRQhldqlqynqqflscHDPINIQFTSGTTGSPKGATLSH 302
Cdd:PRK06155 140 LPLPAvwLLDAPASVSVPAgwstaPLPP---LDAPAPAAAVQP--------------GDTAAILYTSGTTGPSKGVCCPH 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 303 YNIVNNSNILGERLKLHEKtpEQLRMILpnPLYHcLGSVAGTMMCLMYGATLILaSPIFNGKKALEAISRERGTFLYGTP 382
Cdd:PRK06155 203 AQFYWWGRNSAEDLEIGAD--DVLYTTL--PLFH-TNALNAFFQALLAGATYVL-EPRFSASGFWPAVRRHGATVTYLLG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 383 TMFVDILNQPDFSSYDISTMcggVIAGSPA-PPELIRAIINKINMkDLVVAYGTTE-NSPVTFAHfpedtVEQKAESVGR 460
Cdd:PRK06155 277 AMVSILLSQPARESDRAHRV---RVALGPGvPAALHAAFRERFGV-DLLDGYGSTEtNFVIAVTH-----GSQRPGSMGR 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 461 IMPHTEARIMNmEAGTLAKLNTPGELCIRG---YCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDM 537
Cdd:PRK06155 348 LAPGFEARVVD-EHDQELPDGEPGELLLRAdepFAFATGYFGMPEKTVEAW-RNLWFHTGDRVVRDADGWFRFVDRIKDA 425
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 538 IIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNY 617
Cdd:PRK06155 426 IRRRGENISSFEVEQVLLSHPAVAAAAVFPVPSELGEDEVMAAVVLRDGTALEPVALVRHCEPRLAYFAVPRYVEFVAAL 505
|
570
....*....|....*.
gi 572872742 618 PLTISGKIQKFKLREQ 633
Cdd:PRK06155 506 PKTENGKVQKFVLREQ 521
|
|
| PLN02246 |
PLN02246 |
4-coumarate--CoA ligase |
102-635 |
5.82e-57 |
|
4-coumarate--CoA ligase
Pssm-ID: 215137 [Multi-domain] Cd Length: 537 Bit Score: 201.36 E-value: 5.82e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 102 CLETTAQrVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNP 181
Cdd:PLN02246 29 CFERLSE-FSDRPCLIDGATGRVYTYADVELLSRRVAAGLHKLGIRQGDVVMLLLPNCPEFVLAFLGASRRGAVTTTANP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 182 AYQAMELEYVLKKVGCKALVfpkqfkTQ-QYYNVLKQICPEvenaqpgalksqrlpDLTTVISVDAPLPGTLLLDEVVAA 260
Cdd:PLN02246 108 FYTPAEIAKQAKASGAKLII------TQsCYVDKLKGLAED---------------DGVTVVTIDDPPEGCLHFSELTQA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 261 GSTRqhLDQLQYNQQflschDPINIQFTSGTTGSPKGATLSHYNIVNN--SNILGERLKLHEKTPEQLRMILPnpLYH-- 336
Cdd:PLN02246 167 DENE--LPEVEISPD-----DVVALPYSSGTTGLPKGVMLTHKGLVTSvaQQVDGENPNLYFHSDDVILCVLP--MFHiy 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 337 CLGSVagtMMC-LMYGATlILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMcGGVIAG-SPAPP 414
Cdd:PLN02246 238 SLNSV---LLCgLRVGAA-ILIMPKFEIGALLELIQRHKVTIAPFVPPIVLAIAKSPVVEKYDLSSI-RMVLSGaAPLGK 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 415 ELIRAIINKINMKDLVVAYGTTENSPV-----TFAHFPEDTveqKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIR 489
Cdd:PLN02246 313 ELEDAFRAKLPNAVLGQGYGMTEAGPVlamclAFAKEPFPV---KSGSCGTVVRNAELKIVDPETGASLPRNQPGEICIR 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 490 GYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVK 569
Cdd:PLN02246 390 GPQIMKGYLNDPEATANTIDKDGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLISHPSIADAAVVPMK 469
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572872742 570 DDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQME 635
Cdd:PLN02246 470 DEVAGEVPVAFVVRSNGSEITEDEIKQFVAKQVVFYKRIHKVFFVDSIPKAPSGKILRKDLRAKLA 535
|
|
| BCL_like |
cd05919 |
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ... |
118-631 |
3.91e-55 |
|
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate CoA ligase (BCL) and related ligases that catalyze the acylation of benzoate derivatives, 2-aminobenzoate and 4-hydroxybenzoate. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Xenobiotic aromatic compounds are also a major class of man-made pollutants. Some bacteria use benzoate as the sole source of carbon and energy through benzoate degradation. Benzoate degradation starts with its activation to benzoyl-CoA by benzoate CoA ligase. The reaction catalyzed by benzoate CoA ligase proceeds via a two-step process; the first ATP-dependent step forms an acyl-AMP intermediate, and the second step forms the acyl-CoA ester with release of the AMP.
Pssm-ID: 341243 [Multi-domain] Cd Length: 436 Bit Score: 193.83 E-value: 3.91e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 118 VLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGC 197
Cdd:cd05919 4 FYAADRSVTYGQLHDGANRLGSALRNLGVSSGDRVLLLMLDSPELVQLFLGCLARGAIAVVINPLLHPDDYAYIARDCEA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 198 KALVfpkqfktqqyynvlkqicpevenaqpgalksqrlpdlttvisvdaplpgtllldevvaagstrQHLDQLQYnqqfl 277
Cdd:cd05919 84 RLVV---------------------------------------------------------------TSADDIAY----- 95
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 278 schdpinIQFTSGTTGSPKGATLSHYNIVNNSNILG-ERLKLhekTPEQLRMILPNpLYHCLGSVAGTMMCLMYGATLIL 356
Cdd:cd05919 96 -------LLYSSGTTGPPKGVMHAHRDPLLFADAMArEALGL---TPGDRVFSSAK-MFFGYGLGNSLWFPLAVGASAVL 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 357 ASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRA--------IINKInmkd 428
Cdd:cd05919 165 NPGWPTAERVLATLARFRPTVLYGVPTFYANLLDSCAGSPDALRSLRLCVSAGEALPRGLGERwmehfggpILDGI---- 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 429 lvvayGTTENSPVTFAHFPEDTveqKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAV 508
Cdd:cd05919 241 -----GATEVGHIFLSNRPGAW---RLGSTGRPVPGYEIRLVD-EEGHTIPPGEEGDLLVRGPSAAVGYWNNPEKSRATF 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 509 dQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDG-- 586
Cdd:cd05919 312 -NGGWYRTGDKFCRDADGWYTHAGRADDMLKVGGQWVSPVEVESLIIQHPAVAEAAVVAVPESTGLSRLTAFVVLKSPaa 390
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 572872742 587 -EETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05919 391 pQESLARDIHRHLLERLSAHKVPRRIAFVDELPRTATGKLQRFKLR 436
|
|
| PRK07514 |
PRK07514 |
malonyl-CoA synthase; Validated |
109-633 |
6.54e-55 |
|
malonyl-CoA synthase; Validated
Pssm-ID: 181011 [Multi-domain] Cd Length: 504 Bit Score: 195.09 E-value: 6.54e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 109 RVPEREALVVLHED-VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAME 187
Cdd:PRK07514 12 AFADRDAPFIETPDgLRYTYGDLDAASARLANLLVALGVKPGDRVAVQVEKSPEALALYLATLRAGAVFLPLNTAYTLAE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 188 LEYVLKKVGCKALVF-PKQFKTqqyynvLKQICpevenAQPGAlksqrlpdlTTVISVDAPLPGTLLldeVVAAGSTRQH 266
Cdd:PRK07514 92 LDYFIGDAEPALVVCdPANFAW------LSKIA-----AAAGA---------PHVETLDADGTGSLL---EAAAAAPDDF 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 267 LDqlqynqqfLSCH--DPINIQFTSGTTGSPKGATLSHYNIVNNSnilgerLKLHEK---TPEQlRMILPNPLYHCLGSV 341
Cdd:PRK07514 149 ET--------VPRGadDLAAILYTSGTTGRSKGAMLSHGNLLSNA------LTLVDYwrfTPDD-VLIHALPIFHTHGLF 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 342 AGTMMCLMYGATLILAsPIFNGKKALEAIsrERGTFLYGTPTMFVDILNQPDFSSydisTMCGGV---IAGSpAP--PEL 416
Cdd:PRK07514 214 VATNVALLAGASMIFL-PKFDPDAVLALM--PRATVMMGVPTFYTRLLQEPRLTR----EAAAHMrlfISGS-APllAET 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 417 IR--------AIINKinmkdlvvaYGTTENSPVTfaHFPEDTvEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCI 488
Cdd:PRK07514 286 HRefqertghAILER---------YGMTETNMNT--SNPYDG-ERRAGTVGFPLPGVSLRVTDPETGAELPPGEIGMIEV 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 489 RGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGV 568
Cdd:PRK07514 354 KGPNVFKGYWRMPEKTAEEFRADGFFITGDLGKIDERGYVHIVGRGKDLIISGGYNVYPKEVEGEIDELPGVVESAVIGV 433
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572872742 569 KDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK07514 434 PHPDFGEGVTAVVVPKPGAALDEAAILAALKGRLARFKQPKRVFFVDELPRNTMGKVQKNLLREQ 498
|
|
| ACLS-CaiC |
cd17637 |
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ... |
281-625 |
2.84e-54 |
|
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized, but may be similar to Carnitine-CoA ligase (CaiC) which catalyzes the transfer of CoA to carnitine. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341292 [Multi-domain] Cd Length: 333 Bit Score: 188.25 E-value: 2.84e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 281 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLG-SVAGTMMClMYGATLILASp 359
Cdd:cd17637 1 DPFVIIHTAAVAGRPRGAVLSHGNLIAANLQLIHAMGLTEAD----VYLNMLPLFHIAGlNLALATFH-AGGANVVMEK- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 360 iFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMcgGVIAGSPAPpELIRAIINKINMKdLVVAYGTTENS 439
Cdd:cd17637 75 -FDPAEALELIEEEKVTLMGSFPPILSNLLDAAEKSGVDLSSL--RHVLGLDAP-ETIQRFEETTGAT-FWSLYGQTETS 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 440 -PVTFAHFPEdtveqKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDqDKWYWTGD 518
Cdd:cd17637 150 gLVTLSPYRE-----RPGSAGRPGPLVRVRIVD-DNDRPVPAGETGEIVVRGPLVFQGYWNLPELTAYTFR-NGWHHTGD 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 519 VATMNEQGFCKIVGRS--KDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKA 596
Cdd:cd17637 223 LGRFDEDGYLWYAGRKpeKELIKPGGENVYPAEVEKVILEHPAIAEVCVIGVPDPKWGEGIKAVCVLKPGATLTADELIE 302
|
330 340
....*....|....*....|....*....
gi 572872742 597 FCKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:cd17637 303 FVGSRIARYKKPRYVVFVEALPKTADGSI 331
|
|
| FACL_like_6 |
cd05922 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
137-631 |
9.24e-54 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341246 [Multi-domain] Cd Length: 457 Bit Score: 190.73 E-value: 9.24e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 137 AASGLLSIGLCKGDR--LGMWGPNSYAWVLMQLATAQA--GIILVSVNPAYQAMELEYVLKKVGCKaLVFPkqfktqqyy 212
Cdd:cd05922 6 AASALLEAGGVRGERvvLILPNRFTYIELSFAVAYAGGrlGLVFVPLNPTLKESVLRYLVADAGGR-IVLA--------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 213 nvlkqicpevenaQPGALksqrlpDLTTVISVDAPLPGT-LLLDEVVAAGSTRQhldqlqynqQFLSCH-DPINIQFTSG 290
Cdd:cd05922 76 -------------DAGAA------DRLRDALPASPDPGTvLDADGIRAARASAP---------AHEVSHeDLALLLYTSG 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 291 TTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMilpnPLYHCLG-SVAGTMmcLMYGATLILASPIFNGKKALEA 369
Cdd:cd05922 128 STGSPKLVRLSHQNLLANARSIAEYLGITADDRALTVL----PLSYDYGlSVLNTH--LLRGATLVLTNDGVLDDAFWED 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 370 ISRERGTFLYGTPTMFvDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPvTFAHFPED 449
Cdd:cd05922 202 LREHGATGLAGVPSTY-AMLTRLGFDPAKLPSLRYLTQAGGRLPQETIARLRELLPGAQVYVMYGQTEATR-RMTYLPPE 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 450 TVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCK 529
Cdd:cd05922 280 RILEKPGSIGLAIPGGEFEILD-DDGTPTPPGEPGEIVHRGPNVMKGYWNDPPYRRKEGRGGGVLHTGDLARRDEDGFLF 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 530 IVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVkDDRMGEEICACIRLKDGEEttVEEIKAFCKGKISHFKIPK 609
Cdd:cd05922 359 IVGRRDRMIKLFGNRISPTEIEAAARSIGLIIEAAAVGL-PDPLGEKLALFVTAPDKID--PKDVLRSLAERLPPYKVPA 435
|
490 500
....*....|....*....|..
gi 572872742 610 YIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05922 436 TVRVVDELPLTASGKVDYAALR 457
|
|
| A_NRPS |
cd05930 |
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ... |
111-625 |
1.03e-53 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 190.05 E-value: 1.03e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 111 PEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEY 190
Cdd:cd05930 1 PDAVAVV--DGDQSLTYAELDARANRLARYLRERGVGPGDLVAVLLERSLEMVVAILAVLKAGAAYVPLDPSYPAERLAY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 191 VLKKVGCKALVfpkqfktqqyynvlkqicpevenAQPGalksqrlpDLTTVIsvdaplpgtllldevvaagstrqhldql 270
Cdd:cd05930 79 ILEDSGAKLVL-----------------------TDPD--------DLAYVI---------------------------- 99
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 271 qynqqflschdpiniqFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEktpeQLRMILPNPLYHCLgSVAGTMMCLMY 350
Cdd:cd05930 100 ----------------YTSGSTGKPKGVMVEHRGLVNLLLWMQEAYPLTP----GDRVLQFTSFSFDV-SVWEIFGALLA 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 351 GATLILASP--IFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSsydistMCGG----VIAGSPAPPELIRAIINKI 424
Cdd:cd05930 159 GATLVVLPEevRKDPEALADLLAEEGITVLHLTPSLLRLLLQELELA------ALPSlrlvLVGGEALPPDLVRRWRELL 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 425 NMKDLVVAYGTTENS-PVTFAHFPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQK 503
Cdd:cd05930 233 PGARLVNLYGPTEATvDATYYRVPPDDEEDGRVPIGRPIPNTRVYVLD-ENLRPVPPGVPGELYIGGAGLARGYLNRPEL 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 504 TEEAVDQDKW------YWTGDVATMNEQGFCKIVGRSKDMI-IRGgeniY---PAELEDFFHTHPKVQEVQVVGVKDDRM 573
Cdd:cd05930 312 TAERFVPNPFgpgermYRTGDLVRWLPDGNLEFLGRIDDQVkIRG----YrieLGEIEAALLAHPGVREAAVVAREDGDG 387
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 572872742 574 GEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:cd05930 388 EKRLVAYVVPDEGGELDEEELRAHLAERLPDYMVPSAFVVLDALPLTPNGKV 439
|
|
| FACL_like_4 |
cd05944 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
288-631 |
1.61e-53 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341266 [Multi-domain] Cd Length: 359 Bit Score: 187.30 E-value: 1.61e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 288 TSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGATLILASPI-FNGKKA 366
Cdd:cd05944 10 TGGTTGTPKLAQHTHSNEVYNAWMLALNSLFDPDD----VLLCGLPLFHVNGSVVTLLTPLASGAHVVLAGPAgYRNPGL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 367 LEA----ISRERGTFLYGTPTMFVDILNQPDfsSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSPVT 442
Cdd:cd05944 86 FDNfwklVERYRITSLSTVPTVYAALLQVPV--NADISSLRFAMSGAAPLPVELRARFEDATGLP-VVEGYGLTEATCLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 443 FAHFPEDtvEQKAESVGRIMPHTEARIMNMEAGTLAKL----NTPGELCIRGYCVMLGY-WGEPQKteEAVDQDKWYWTG 517
Cdd:cd05944 163 AVNPPDG--PKRPGSVGLRLPYARVRIKVLDGVGRLLRdcapDEVGEICVAGPGVFGGYlYTEGNK--NAFVADGWLNTG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 518 DVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAF 597
Cdd:cd05944 239 DLGRLDADGYLFITGRAKDLIIRGGHNIDPALIEEALLRHPAVAFAGAVGQPDAHAGELPVAYVQLKPGAVVEEEELLAW 318
|
330 340 350
....*....|....*....|....*....|....*
gi 572872742 598 CKGKI-SHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05944 319 ARDHVpERAAVPKHIEVLEELPVTAVGKVFKPALR 353
|
|
| 23DHB-AMP_lg |
cd05920 |
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ... |
97-627 |
7.67e-53 |
|
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate. However, it can also catalyze the ATP-PPi exchange for 2,3-DHB analogs, such as salicyclic acid (o-hydrobenzoate), as well as 2,4-DHB and 2,5-DHB, but with less efficiency. Proteins in this family are the stand-alone adenylation components of non-ribosomal peptide synthases (NRPSs) involved in the biosynthesis of siderophores, which are low molecular weight iron-chelating compounds synthesized by many bacteria to aid in the acquisition of this vital trace elements. In Escherichia coli, the 2,3-dihydroxybenzoate-AMP ligase is called EntE, the adenylation component of the enterobactin NRPS system.
Pssm-ID: 341244 [Multi-domain] Cd Length: 482 Bit Score: 188.69 E-value: 7.67e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 97 KTVGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIIL 176
Cdd:cd05920 15 EPLGDLLARSAARHPDRIAVV--DGDRRLTYRELDRRADRLAAGLRGLGIRPGDRVVVQLPNVAEFVVLFFALLRLGAVP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 177 VSVNPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNvlkqicpevenaqpgalksqrlpdlttvisvdaplpgtlLLDE 256
Cdd:cd05920 93 VLALPSHRRSELSAFCAHAEAVAYIVPDRHAGFDHRA---------------------------------------LARE 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 257 VVAagstrqhldqlqynqqflSCHDPINIQFTSGTTGSPKGATLSH----YNIVNNSNILGerlkLHEKTpeqlRMILPN 332
Cdd:cd05920 134 LAE------------------SIPEVALFLLSGGTTGTPKLIPRTHndyaYNVRASAEVCG----LDQDT----VYLAVL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 333 PLYH-----CLGsVAGTMMClmyGATLILASPIfNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVI 407
Cdd:cd05920 188 PAAHnfplaCPG-VLGTLLA---GGRVVLAPDP-SPDAAFPLIEREGVTVTALVPALVSLWLDAAASRRADLSSLRLLQV 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 408 AGSPAPPELIRAIINKINMKdLVVAYGTTENSpVTFAHFpEDTVEQKAESVGRIM-PHTEARIMNmEAGTLAKLNTPGEL 486
Cdd:cd05920 263 GGARLSPALARRVPPVLGCT-LQQVFGMAEGL-LNYTRL-DDPDEVIIHTQGRPMsPDDEIRVVD-EEGNPVPPGEEGEL 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 487 CIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVV 566
Cdd:cd05920 339 LTRGPYTIRGYYRAPEHNARAFTPDGFYRTGDLVRRTPDGYLVVEGRIKDQINRGGEKIAAEEVENLLLRHPAVHDAAVV 418
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 572872742 567 GVKDDRMGEEICACIRLKDgEETTVEEIKAFCKGK-ISHFKIPKYIVFVTNYPLTISGKIQK 627
Cdd:cd05920 419 AMPDELLGERSCAFVVLRD-PPPSAAQLRRFLRERgLAAYKLPDRIEFVDSLPLTAVGKIDK 479
|
|
| BACL_like |
cd05929 |
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ... |
285-632 |
2.31e-52 |
|
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes the formation of bile acid-CoA conjugates in a two-step reaction: the formation of a bile acid-AMP molecule as an intermediate, followed by the formation of a bile acid-CoA. This ligase requires a bile acid with a free carboxyl group, ATP, Mg2+, and CoA for synthesis of the final bile acid-CoA conjugate. The bile acid-CoA ligation is believed to be the initial step in the bile acid 7alpha-dehydroxylation pathway in the intestinal bacterium Eubacterium sp.
Pssm-ID: 341252 [Multi-domain] Cd Length: 473 Bit Score: 187.20 E-value: 2.31e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 285 IQFTSGTTGSPKG--ATLSHyNIVNNSNILGERLKLhEKTPEQlRMILPNPLYHCLGSVAgTMMCLMYGATLILAsPIFN 362
Cdd:cd05929 130 MLYSGGTTGRPKGikRGLPG-GPPDNDTLMAAALGF-GPGADS-VYLSPAPLYHAAPFRW-SMTALFMGGTLVLM-EKFD 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 363 GKKALEAISRERGTFLYGTPTMFVDILNQPD--FSSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSP 440
Cdd:cd05929 205 PEEFLRLIERYRVTFAQFVPTMFVRLLKLPEavRNAYDLSSLKRVIHAAAPCPPWVKEQWIDWGGPI-IWEYYGGTEGQG 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 441 VTFAHfPEDTVEQKAeSVGRIMpHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLgYWGEPQKTEEAVDQDKWYWTGDVA 520
Cdd:cd05929 284 LTIIN-GEEWLTHPG-SVGRAV-LGKVHILD-EDGNEVPPGEIGEVYFANGPGFE-YTNDPEKTAAARNEGGWSTLGDVG 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 521 TMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTV---EEIKAF 597
Cdd:cd05929 359 YLDEDGYLYLTDRRSDMIISGGVNIYPQEIENALIAHPKVLDAAVVGVPDEELGQRVHAVVQPAPGADAGTalaEELIAF 438
|
330 340 350
....*....|....*....|....*....|....*
gi 572872742 598 CKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:cd05929 439 LRDRLSRYKCPRSIEFVAELPRDDTGKLYRRLLRD 473
|
|
| ABCL |
cd05958 |
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ... |
106-631 |
1.30e-51 |
|
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate aerobic degradation pathway by activating 2-aminobenzoate to 2-aminobenzoyl-CoA. The reaction is carried out via a two-step process; the first step is ATP-dependent and forms a 2-aminobenzoyl-AMP intermediate, and the second step forms the 2-aminobenzoyl-CoA ester and releases the AMP. 2-Aminobenzoyl-CoA is further converted to 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA catalyzed by 2-aminobenzoyl-CoA monooxygenase/reductase. ABCL has been purified from cells aerobically grown with 2-aminobenzoate as sole carbon, energy, and nitrogen source, and has been characterized as a monomer.
Pssm-ID: 341268 [Multi-domain] Cd Length: 439 Bit Score: 184.22 E-value: 1.30e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 106 TAQRVPEREalvvlhedvrLTFAQLKEEVDKAASGLLS-IGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQ 184
Cdd:cd05958 2 TCLRSPERE----------WTYRDLLALANRIANVLVGeLGIVPGNRVLLRGSNSPELVACWFGIQKAGAIAVATMPLLR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 185 AMELEYVLKKvgckalvfpkqfktqqyynvlkqicpevenaqpgalksqrlpdltTVISVdaplpgtLLLDEVVAAGStr 264
Cdd:cd05958 72 PKELAYILDK---------------------------------------------ARITV-------ALCAHALTASD-- 97
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 265 qhldqlqynqqflschDPINIQFTSGTTGSPKGATLSHYNIVNNS-----NILGERlklhektpEQLRMILPNPLYHCLG 339
Cdd:cd05958 98 ----------------DICILAFTSGTTGAPKATMHFHRDPLASAdryavNVLRLR--------EDDRFVGSPPLAFTFG 153
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 340 sVAGTMMCLMY-GATLIL---ASPifngKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPE 415
Cdd:cd05958 154 -LGGVLLFPFGvGASGVLleeATP----DLLLSAIARYKPTVLFTAPTAYRAMLAHPDAAGPDLSSLRKCVSAGEALPAA 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 416 LIRAIINKINMkDLVVAYGTTENSPVTFAHFPEDTveqKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCvml 495
Cdd:cd05958 229 LHRAWKEATGI-PIIDGIGSTEMFHIFISARPGDA---RPGATGKPVPGYEAKVVD-DEGNPVPDGTIGRLAVRGPT--- 300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 496 GYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGE 575
Cdd:cd05958 301 GCRYLADKRQRTYVQGGWNITGDTYSRDPDGYFRHQGRSDDMIVSGGYNIAPPEVEDVLLQHPAVAECAVVGHPDESRGV 380
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 572872742 576 EICACIRLKDGE---ETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05958 381 VVKAFVVLRPGVipgPVLARELQDHAKAHIAPYKYPRAIEFVTELPRTATGKLQRFALR 439
|
|
| AAS_C |
cd05909 |
C-terminal domain of the acyl-acyl carrier protein synthetase (also called ... |
149-625 |
2.02e-51 |
|
C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Acyl-acyl carrier protein synthase (Aas) is a membrane protein responsible for a minor pathway of incorporating exogenous fatty acids into membrane phospholipids. Its in vitro activity is characterized by the ligation of free fatty acids between 8 and 18 carbons in length to the acyl carrier protein sulfydryl group (ACP-SH) in the presence of ATP and Mg2+. However, its in vivo function is as a 2-acylglycerophosphoethanolamine (2-acyl-GPE) acyltransferase. The reaction occurs in two steps: the acyl chain is first esterified to acyl carrier protein (ACP) via a thioester bond, followed by a second step where the acyl chain is transferred to a 2-acyllysophospholipid, thus completing the transacylation reaction. This model represents the C-terminal domain of the enzyme, which belongs to the class I adenylate-forming enzyme family, including acyl-CoA synthetases.
Pssm-ID: 341235 [Multi-domain] Cd Length: 490 Bit Score: 185.23 E-value: 2.02e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 149 GDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFPKQFktqqyynvlkqicpeVENaqpg 228
Cdd:cd05909 31 GENVGVMLPPSAGGALANFALALSGKVPVMLNYTAGLRELRACIKLAGIKTVLTSKQF---------------IEK---- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 229 aLKSQRLPDLTT---VISVDaPLPGTLLLDEVVAAGSTRQHLDQLQYNQQFLSC---HDPINIQFTSGTTGSPKGATLSH 302
Cdd:cd05909 92 -LKLHHLFDVEYdarIVYLE-DLRAKISKADKCKAFLAGKFPPKWLLRIFGVAPvqpDDPAVILFTSGSEGLPKGVVLSH 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 303 YNIVNNSnilgERLKLHEKTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTP 382
Cdd:cd05909 170 KNLLANV----EQITAIFDPNPEDVVFGALPFFHSFGLTGCLWLPLLSGIKVVFHPNPLDYKKIPELIYDKKATILLGTP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 383 TMFVDILNQPdfSSYDISTMcGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEdtVEQKAESVGRIM 462
Cdd:cd05909 246 TFLRGYARAA--HPEDFSSL-RLVVAGAEKLKDTLRQEFQEKFGIRILEGYGTTECSPVISVNTPQ--SPNKEGTVGRPL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 463 PHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGG 542
Cdd:cd05909 321 PGMEVKIVSVETHEEVPIGEGGLLLVRGPNVMLGYLNEPELTSFAF-GDGWYDTGDIGKIDGEGFLTITGRLSRFAKIAG 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 543 ENIYPAELEDFFHTH-PKVQEVQVVGVKDDRMGEEICACIrlkDGEETTVEEIKAFCK-GKISHFKIPKYIVFVTNYPLT 620
Cdd:cd05909 400 EMVSLEAIEDILSEIlPEDNEVAVVSVPDGRKGEKIVLLT---TTTDTDPSSLNDILKnAGISNLAKPSYIHQVEEIPLL 476
|
....*
gi 572872742 621 ISGKI 625
Cdd:cd05909 477 GTGKP 481
|
|
| OSB_MenE-like |
cd17630 |
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ... |
281-632 |
2.20e-51 |
|
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.
Pssm-ID: 341285 [Multi-domain] Cd Length: 325 Bit Score: 180.22 E-value: 2.20e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 281 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHclgsVAGTMM---CLMYGATLILA 357
Cdd:cd17630 1 RLATVILTSGSTGTPKAVVHTAANLLASAAGLHSRLGFGGGD----SWLLSLPLYH----VGGLAIlvrSLLAGAELVLL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 358 SPifngkKALEAISRERG--TFLYGTPTMFVDILnQPDFSSYDISTMCGGVIAGSPAPPEL-IRAIINKINmkdLVVAYG 434
Cdd:cd17630 73 ER-----NQALAEDLAPPgvTHVSLVPTQLQRLL-DSGQGPAALKSLRAVLLGGAPIPPELlERAADRGIP---LYTTYG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 435 TTENSPVTFAHFPEDTveqKAESVGRIMPHTEARIMNmeagtlaklntPGELCIRGYCVMLGYWGEPqkTEEAVDQDKWY 514
Cdd:cd17630 144 MTETASQVATKRPDGF---GRGGVGVLLPGRELRIVE-----------DGEIWVGGASLAMGYLRGQ--LVPEFNEDGWF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 515 WTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDgeETTVEEI 594
Cdd:cd17630 208 TTKDLGELHADGRLTVLGRADNMIISGGENIQPEEIEAALAAHPAVRDAFVVGVPDEELGQRPVAVIVGRG--PADPAEL 285
|
330 340 350
....*....|....*....|....*....|....*...
gi 572872742 595 KAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:cd17630 286 RAWLKDKLARFKLPKRIYPVPELPRTGGGKVDRRALRA 323
|
|
| AFD_YhfT-like |
cd17633 |
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ... |
281-625 |
3.74e-51 |
|
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, as well as long-chain fatty acid-CoA ligase VraA, all of which are as yet to be characterized. These proteins belong to the adenylate-forming enzymes which catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain
Pssm-ID: 341288 [Multi-domain] Cd Length: 320 Bit Score: 179.52 E-value: 3.74e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 281 DPINIQFTSGTTGSPKGATLSHYNIVNnSNILGERLkLHEKTPEqlRMILPNPLYHCLgSVAGTMMCLMYGATLILASpI 360
Cdd:cd17633 1 NPFYIGFTSGTTGLPKAYYRSERSWIE-SFVCNEDL-FNISGED--AILAPGPLSHSL-FLYGAISALYLGGTFIGQR-K 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 361 FNGKKALEAISRERGTFLYGTPTMfVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINmkdLVVAYGTTENSP 440
Cdd:cd17633 75 FNPKSWIRKINQYNATVIYLVPTM-LQALARTLEPESKIKSIFSSGQKLFESTKKKLKNIFPKAN---LIEFYGTSELSF 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 441 VTFaHFPEDtvEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVmlgywgepqktEEAVDQDKWYWTGDVA 520
Cdd:cd17633 151 ITY-NFNQE--SRPPNSVGRPFPNVEIEIRNADGGEIGKIFVKSEMVFSGYVR-----------GGFSNPDGWMSVGDIG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 521 TMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRlkdGEETTVEEIKAFCKG 600
Cdd:cd17633 217 YVDEEGYLYLVGRESDMIIIGGINIFPTEIESVLKAIPGIEEAIVVGIPDARFGEIAVALYS---GDKLTYKQLKRFLKQ 293
|
330 340
....*....|....*....|....*
gi 572872742 601 KISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:cd17633 294 KLSRYEIPKKIIFVDSLPYTSSGKI 318
|
|
| PRK07638 |
PRK07638 |
acyl-CoA synthetase; Validated |
106-635 |
6.86e-50 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236071 [Multi-domain] Cd Length: 487 Bit Score: 180.75 E-value: 6.86e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 106 TAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGlCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQA 185
Cdd:PRK07638 10 HASLQPNKIAIK--ENDRVLTYKDWFESVCKVANWLNEKE-SKNKTIAILLENRIEFLQLFAGAAMAGWTCVPLDIKWKQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 186 MELEYVLKkVGCKALVFPKQFKTQQYYNVLkqiCPEVENAQPGALKSQRLPDLTTVISVDaplpgtllldevvaagstrq 265
Cdd:PRK07638 87 DELKERLA-ISNADMIVTERYKLNDLPDEE---GRVIEIDEWKRMIEKYLPTYAPIENVQ-------------------- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 266 hldqlqynqqflscHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQlRMILPNPLYHCLgSVAGTM 345
Cdd:PRK07638 143 --------------NAPFYMGFTSGSTGKPKAFLRAQQSWLHSFDCNVHDFHM---KRED-SVLIAGTLVHSL-FLYGAI 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 346 MCLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTM---FVDILNQPDFSSYDISTmcggviaGSPAPPELIRAIIN 422
Cdd:PRK07638 204 STLYVGQTVHLM-RKFIPNQVLDKLETENISVMYTVPTMlesLYKENRVIENKMKIISS-------GAKWEAEAKEKIKN 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 423 KINMKDLVVAYGTTENSPVTFAHfPEDTvEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQ 502
Cdd:PRK07638 276 IFPYAKLYEFYGASELSFVTALV-DEES-ERRPNSVGRPFHNVQVRICN-EAGEEVQKGEIGTVYVKSPQFFMGYIIGGV 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 503 KTEEaVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIr 582
Cdd:PRK07638 353 LARE-LNADGWMTVRDVGYEDEEGFIYIVGREKNMILFGGINIFPEEIESVLHEHPAVDEIVVIGVPDSYWGEKPVAII- 430
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 572872742 583 lkDGEEtTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQME 635
Cdd:PRK07638 431 --KGSA-TKQQLKSFCLQRLSSFKIPKEWHFVDEIPYTNSGKIARMEAKSWIE 480
|
|
| PRK07008 |
PRK07008 |
long-chain-fatty-acid--CoA ligase; Validated |
124-637 |
1.31e-49 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235908 [Multi-domain] Cd Length: 539 Bit Score: 181.06 E-value: 1.31e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 124 RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFP 203
Cdd:PRK07008 39 RYTYRDCERRAKQLAQALAALGVEPGDRVGTLAWNGYRHLEAYYGVSGSGAVCHTINPRLFPEQIAYIVNHAEDRYVLFD 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 204 KQFKTqqyynVLKQICPEVENAQPGALKSQR--LPDLTTvisvdaPLpgtLLLDEVVAAGSTRQHLDQLQYNQQFLSChd 281
Cdd:PRK07008 119 LTFLP-----LVDALAPQCPNVKGWVAMTDAahLPAGST------PL---LCYETLVGAQDGDYDWPRFDENQASSLC-- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 282 piniqFTSGTTGSPKGATLSHYNIVnnsnilgerlkLH---EKTPEQLRM-----ILP-NPLYHCLG-----SVAgtmmc 347
Cdd:PRK07008 183 -----YTSGTTGNPKGALYSHRSTV-----------LHaygAALPDAMGLsardaVLPvVPMFHVNAwglpySAP----- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 348 lMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMK 427
Cdd:PRK07008 242 -LTGAKLVLPGPDLDGKSLYELIEAERVTFSAGVPTVWLGLLNHMREAGLRFSTLRRTVIGGSACPPAMIRTFEDEYGVE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 428 dLVVAYGTTENSPV------TFAH--FPEDTVEQKAESVGRIMPHTEARIMNMEAGTL---AKlnTPGELCIRGYCVMLG 496
Cdd:PRK07008 321 -VIHAWGMTEMSPLgtlcklKWKHsqLPLDEQRKLLEKQGRVIYGVDMKIVGDDGRELpwdGK--AFGDLQVRGPWVIDR 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 497 YWgepqKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEE 576
Cdd:PRK07008 398 YF----RGDASPLVDGWFPTGDVATIDADGFMQITDRSKDVIKSGGEWISSIDIENVAVAHPAVAEAACIACAHPKWDER 473
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572872742 577 ICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMERH 637
Cdd:PRK07008 474 PLLVVVKRPGAEVTREELLAFYEGKVAKWWIPDDVVFVDAIPHTATGKLQKLKLREQFRDY 534
|
|
| PRK13382 |
PRK13382 |
bile acid CoA ligase; |
98-632 |
2.33e-49 |
|
bile acid CoA ligase;
Pssm-ID: 172019 [Multi-domain] Cd Length: 537 Bit Score: 180.34 E-value: 2.33e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 98 TVGqcLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILV 177
Cdd:PRK13382 46 TSG--FAIAAQRCPDRPGLI--DELGTLTWRELDERSDALAAALQALPIGEPRVVGIMCRNHRGFVEALLAANRIGADIL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 178 SVNPAYQAMELEYVLKKVGCKALVFPKQFktqqyynvlkqiCPEVENA---QPGALKSQRLPDLTTVISVDApLPGTLLL 254
Cdd:PRK13382 122 LLNTSFAGPALAEVVTREGVDTVIYDEEF------------SATVDRAladCPQATRIVAWTDEDHDLTVEV-LIAAHAG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 255 DEVVAAGSTRQhldqlqynqqflschdpiNIQFTSGTTGSPKGATLSHY-NIVNNSNILgERLKLHEKTPeqlrMILPNP 333
Cdd:PRK13382 189 QRPEPTGRKGR------------------VILLTSGTTGTPKGARRSGPgGIGTLKAIL-DRTPWRAEEP----TVIVAP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 334 LYHCLG----SVAGTMMCLMygatliLASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPD--FSSYDISTMCGGVI 407
Cdd:PRK13382 246 MFHAWGfsqlVLAASLACTI------VTRRRFDPEATLDLIDRHRATGLAVVPVMFDRIMDLPAevRNRYSGRSLRFAAA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 408 AGSPAPPELIRAIINKINmkDLVVA-YGTTENSPVTFAHfPEDtVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTpGEL 486
Cdd:PRK13382 320 SGSRMRPDVVIAFMDQFG--DVIYNnYNATEAGMIATAT-PAD-LRAAPDTAGRPAEGTEIRILDQDFREVPTGEV-GTI 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 487 CIRGYCVMLGYwgEPQKTEEAvdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVV 566
Cdd:PRK13382 395 FVRNDTQFDGY--TSGSTKDF--HDGFMASGDVGYLDENGRLFVVGRDDEMIVSGGENVYPIEVEKTLATHPDVAEAAVI 470
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572872742 567 GVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:PRK13382 471 GVDDEQYGQRLAAFVVLKPGASATPETLKQHVRDNLANYKVPRDIVVLDELPRGATGKILRRELQA 536
|
|
| PLN03102 |
PLN03102 |
acyl-activating enzyme; Provisional |
103-632 |
7.77e-49 |
|
acyl-activating enzyme; Provisional
Pssm-ID: 215576 [Multi-domain] Cd Length: 579 Bit Score: 179.83 E-value: 7.77e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:PLN03102 20 LKRASECYPNRTSII--YGKTRFTWPQTYDRCCRLAASLISLNITKNDVVSVLAPNTPAMYEMHFAVPMAGAVLNPINTR 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKALVFPKQFKTQqYYNVLKQICPEVENAQPGALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAGS 262
Cdd:PLN03102 98 LDATSIAAILRHAKPKILFVDRSFEPL-AREVLHLLSSEDSNLNLPVIFIHEIDFPKRPSSEELDYECLIQRGEPTPSLV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 263 TRQHLDQLQynqqflscHDPINIQFTSGTTGSPKGATLSHYN--IVNNSNILGERLKLhekTPEQLRMIlpnPLYHCLG- 339
Cdd:PLN03102 177 ARMFRIQDE--------HDPISLNYTSGTTADPKGVVISHRGayLSTLSAIIGWEMGT---CPVYLWTL---PMFHCNGw 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 340 ----SVA---GTMMCLMYgatlILASPIFNGkkaleaISRERGTFLYGTPTMFVDILNQpdfSSYDISTMCGGV---IAG 409
Cdd:PLN03102 243 tftwGTAargGTSVCMRH----VTAPEIYKN------IEMHNVTHMCCVPTVFNILLKG---NSLDLSPRSGPVhvlTGG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 410 SPAPPELIRAIiNKINMKdLVVAYGTTENS-PVTFAHF-------PEDT-VEQKAESVGRIMPHTEARIMNMEagTLAKL 480
Cdd:PLN03102 310 SPPPAALVKKV-QRLGFQ-VMHAYGLTEATgPVLFCEWqdewnrlPENQqMELKARQGVSILGLADVDVKNKE--TQESV 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 481 ----NTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHT 556
Cdd:PLN03102 386 prdgKTMGEIVIKGSSIMKGYLKNPKATSEAF-KHGWLNTGDVGVIHPDGHVEIKDRSKDIIISGGENISSVEVENVLYK 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 557 HPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAF----------CKGKISHFKIPKYIVFVTNYPLTISGKIQ 626
Cdd:PLN03102 465 YPKVLETAVVAMPHPTWGETPCAFVVLEKGETTKEDRVDKLvtrerdlieyCRENLPHFMCPRKVVFLQELPKNGNGKIL 544
|
....*.
gi 572872742 627 KFKLRE 632
Cdd:PLN03102 545 KPKLRD 550
|
|
| PLN02479 |
PLN02479 |
acetate-CoA ligase |
103-631 |
3.83e-48 |
|
acetate-CoA ligase
Pssm-ID: 178097 [Multi-domain] Cd Length: 567 Bit Score: 177.73 E-value: 3.83e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:PLN02479 26 LERAAVVHPTRKSVV--HGSVRYTWAQTYQRCRRLASALAKRSIGPGSTVAVIAPNIPAMYEAHFGVPMAGAVVNCVNIR 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKALVFpkqfkTQQYYNVLKQICPEVENAQPGALKsqrlPDLTTVISVDAPLPGTLllDEVVAAGS 262
Cdd:PLN02479 104 LNAPTIAFLLEHSKSEVVMV-----DQEFFTLAEEALKILAEKKKSSFK----PPLLIVIGDPTCDPKSL--QYALGKGA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 263 trqhldqLQYnQQFLSCHDP-------------INIQFTSGTTGSPKGATLSHYNI----VNNSNILGerlklhekTPEQ 325
Cdd:PLN02479 173 -------IEY-EKFLETGDPefawkppadewqsIALGYTSGTTASPKGVVLHHRGAylmaLSNALIWG--------MNEG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 326 LRMILPNPLYHC--------LGSVAGTMMCLMYgatlILASPIFNgkkaleAISRERGTFLYGTPTMFVDILNQPDFSSY 397
Cdd:PLN02479 237 AVYLWTLPMFHCngwcftwtLAALCGTNICLRQ----VTAKAIYS------AIANYGVTHFCAAPVVLNTIVNAPKSETI 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 398 -DISTMCGGVIAGSPAPPELIRAIinkiNMKDLVVA--YGTTEN-SPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNME 473
Cdd:PLN02479 307 lPLPRVVHVMTAGAAPPPSVLFAM----SEKGFRVThtYGLSETyGPSTVCAWKPEWDSLPPEEQARLNARQGVRYIGLE 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 474 ----------AGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGE 543
Cdd:PLN02479 383 gldvvdtktmKPVPADGKTMGEIVMRGNMVMKGYLKNPKANEEAF-ANGWFHSGDLGVKHPDGYIEIKDRSKDIIISGGE 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 544 NIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDG-----EETTVEEIKAFCKGKISHFKIPKYIVFvTNYP 618
Cdd:PLN02479 462 NISSLEVENVVYTHPAVLEASVVARPDERWGESPCAFVTLKPGvdksdEAALAEDIMKFCRERLPAYWVPKSVVF-GPLP 540
|
570
....*....|...
gi 572872742 619 LTISGKIQKFKLR 631
Cdd:PLN02479 541 KTATGKIQKHVLR 553
|
|
| A_NRPS_Srf_like |
cd12117 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ... |
104-630 |
4.21e-48 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the adenylation domain of the Bacillus subtilis termination module (Surfactin domain, SrfA-C) which recognizes a specific amino acid building block, which is then activated and transferred to the terminal thiol of the 4'-phosphopantetheine (Ppan) arm of the downstream peptidyl carrier protein (PCP) domain.
Pssm-ID: 341282 [Multi-domain] Cd Length: 483 Bit Score: 175.85 E-value: 4.21e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 104 ETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAY 183
Cdd:cd12117 4 EEQAARTPDAVAVV--YGDRSLTYAELNERANRLARRLRAAGVGPGDVVGVLAERSPELVVALLAVLKAGAAYVPLDPEL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 184 QAMELEYVLKKVGCKALVfpkqfkTQqyynvlkqicpevenaqpGALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAGst 263
Cdd:cd12117 82 PAERLAFMLADAGAKVLL------TD------------------RSLAGRAGGLEVAVVIDEALDAGPAGNPAVPVSP-- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 264 rqhlDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNI---VNNSNILGERlklhektpEQLRMILPNPlyhcLGS 340
Cdd:cd12117 136 ----DDLAY------------VMYTSGSTGRPKGVAVTHRGVvrlVKNTNYVTLG--------PDDRVLQTSP----LAF 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 341 VAGTM---MCLMYGATLILASP--IFNGKKALEAISRERGTFLYGTPTMF---VDIlnQPDfssydistMCGGV----IA 408
Cdd:cd12117 188 DASTFeiwGALLNGARLVLAPKgtLLDPDALGALIAEEGVTVLWLTAALFnqlADE--DPE--------CFAGLrellTG 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 409 GSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQkAESV--GRIMPHTEARIMNmEAGTLAKLNTPGEL 486
Cdd:cd12117 258 GEVVSPPHVRRVLAACPGLRLVNGYGPTENTTFTTSHVVTELDEV-AGSIpiGRPIANTRVYVLD-EDGRPVPPGVPGEL 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 487 CIRGYCVMLGYWGEPQKTEEAVDQD------KWYWTGDVATMNEQGFCKIVGRSKDMI-IRgGENIYPAELEDFFHTHPK 559
Cdd:cd12117 336 YVGGDGLALGYLNRPALTAERFVADpfgpgeRLYRTGDLARWLPDGRLEFLGRIDDQVkIR-GFRIELGEIEAALRAHPG 414
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 572872742 560 VQEVqVVGVKDDRMGE-EICACIRLKdgEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 630
Cdd:cd12117 415 VREA-VVVVREDAGGDkRLVAYVVAE--GALDAAELRAFLRERLPAYMVPAAFVVLDELPLTANGKVDRRAL 483
|
|
| Firefly_Luc |
cd17642 |
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ... |
110-632 |
8.95e-48 |
|
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.
Pssm-ID: 341297 [Multi-domain] Cd Length: 532 Bit Score: 175.79 E-value: 8.95e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 110 VPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELE 189
Cdd:cd17642 30 VPGTIAFTDAHTGVNYSYAEYLEMSVRLAEALKKYGLKQNDRIAVCSENSLQFFLPVIAGLFIGVGVAPTNDIYNERELD 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 190 YVLKKVGCKaLVFPKQFKTQQYYNVLKqicpevenaqpgalksqRLPDLTTVISVDAplpgtllldevvaagstRQHLDQ 269
Cdd:cd17642 110 HSLNISKPT-IVFCSKKGLQKVLNVQK-----------------KLKIIKTIIILDS-----------------KEDYKG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 270 LQYNQQFLSCHDPIN-------------------IQFTSGTTGSPKGATLSHYNIVnnsnilgERLKlHEKTPEQLRMIL 330
Cdd:cd17642 155 YQCLYTFITQNLPPGfneydfkppsfdrdeqvalIMNSSGSTGLPKGVQLTHKNIV-------ARFS-HARDPIFGNQII 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 331 PN-------PLYHCLG--SVAGTMMClmyGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDIST 401
Cdd:cd17642 227 PDtailtviPFHHGFGmfTTLGYLIC---GFRVVLM-YKFEEELFLRSLQDYKVQSALLVPTLFAFFAKSTLVDKYDLSN 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 402 MCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTveqKAESVGRIMPHTEARIMNMEAGTLAKLN 481
Cdd:cd17642 303 LHEIASGGAPLSKEVGEAVAKRFKLPGIRQGYGLTETTSAILITPEGDD---KPGAVGKVVPFFYAKVVDLDTGKTLGPN 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 482 TPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQ 561
Cdd:cd17642 380 ERGELCVKGPMIMKGYVNNPEATKALIDKDGWLHSGDIAYYDEDGHFFIVDRLKSLIKYKGYQVPPAELESILLQHPKIF 459
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 572872742 562 EVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFK-IPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:cd17642 460 DAGVAGIPDEDAGELPAAVVVLEAGKTMTEKEVMDYVASQVSTAKrLRGGVKFVDEVPKGLTGKIDRRKIRE 531
|
|
| PRK06018 |
PRK06018 |
putative acyl-CoA synthetase; Provisional |
123-633 |
2.09e-47 |
|
putative acyl-CoA synthetase; Provisional
Pssm-ID: 235673 [Multi-domain] Cd Length: 542 Bit Score: 174.94 E-value: 2.09e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 123 VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSY----AWV-LMQLataqaGIILVSVNPAYQAMELEYVLKKVGC 197
Cdd:PRK06018 38 VRTTYAQIHDRALKVSQALDRDGIKLGDRVATIAWNTWrhleAWYgIMGI-----GAICHTVNPRLFPEQIAWIINHAED 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 198 KALVFPKQFktqqyYNVLKQICPevenaqpgalksqRLPDLTT-VISVDAP------LPGTLLLDEVVAAGSTRQHLDQL 270
Cdd:PRK06018 113 RVVITDLTF-----VPILEKIAD-------------KLPSVERyVVLTDAAhmpqttLKNAVAYEEWIAEADGDFAWKTF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 271 QYNQQFLSChdpiniqFTSGTTGSPKGATLSHYN------IVNNSNILGERLKlhektpeqlRMILPN-PLYHClGSVAG 343
Cdd:PRK06018 175 DENTAAGMC-------YTSGTTGDPKGVLYSHRSnvlhalMANNGDALGTSAA---------DTMLPVvPLFHA-NSWGI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 344 TMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINk 423
Cdd:PRK06018 238 AFSAPSMGTKLVMPGAKLDGASVYELLDTEKVTFTAGVPTVWLMLLQYMEKEGLKLPHLKMVVCGGSAMPRSMIKAFED- 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 424 inMKDLVV-AYGTTENSPV--------TFAHFPED---TVEQKAesvGRIMPHTEARIMNMEAGTLAKL-NTPGELCIRG 490
Cdd:PRK06018 317 --MGVEVRhAWGMTEMSPLgtlaalkpPFSKLPGDarlDVLQKQ---GYPPFGVEMKITDDAGKELPWDgKTFGRLKVRG 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 491 YCVMLGYWGEPQkteEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKD 570
Cdd:PRK06018 392 PAVAAAYYRVDG---EILDDDGFFDTGDVATIDAYGYMRITDRSKDVIKSGGEWISSIDLENLAVGHPKVAEAAVIGVYH 468
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 572872742 571 DRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK06018 469 PKWDERPLLIVQLKPGETATREEILKYMDGKIAKWWMPDDVAFVDAIPHTATGKILKTALREQ 531
|
|
| MACS_AAE_MA_like |
cd05970 |
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ... |
107-633 |
2.09e-47 |
|
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This family of MACS enzymes is found in archaea and bacteria. It is represented by the acyl-adenylating enzyme from Methanosarcina acetivorans (AAE_MA). AAE_MA is most active with propionate, butyrate, and the branched analogs: 2-methyl-propionate, butyrate, and pentanoate. The specific activity is weaker for smaller or larger acids.
Pssm-ID: 341274 [Multi-domain] Cd Length: 537 Bit Score: 174.99 E-value: 2.09e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 107 AQRVPEREALVVLH---EDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYA-WVLMqLATAQAGIILVSVNPA 182
Cdd:cd05970 27 AKEYPDKLALVWCDdagEERIFTFAELADYSDKTANFFKAMGIGKGDTVMLTLKRRYEfWYSL-LALHKLGAIAIPATHQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKALVFPKQFKTQQyynvlkqicpEVENAQPgalksqRLPDLTTVISVDAPLP-GTLLLDEVVAAG 261
Cdd:cd05970 106 LTAKDIVYRIESADIKMIVAIAEDNIPE----------EIEKAAP------ECPSKPKLVWVGDPVPeGWIDFRKLIKNA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 262 S---TRQHLDQLQYNQqflschDPINIQFTSGTTGSPKgaTLSHynivNNSNILGerlklHEKTPEQLRMILPNPLYHcl 338
Cdd:cd05970 170 SpdfERPTANSYPCGE------DILLVYFSSGTTGMPK--MVEH----DFTYPLG-----HIVTAKYWQNVREGGLHL-- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 339 gSVAGT-----MMCLMYG------ATLILASPIFNGKKALEAISRERGTFLYGTPTMFvDILNQPDFSSYDISTMCGGVI 407
Cdd:cd05970 231 -TVADTgwgkaVWGKIYGqwiagaAVFVYDYDKFDPKALLEKLSKYGVTTFCAPPTIY-RFLIREDLSRYDLSSLRYCTT 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 408 AGSPAPPELIRAIINKINMKdLVVAYGTTENSpVTFAHFPedTVEQKAESVGRIMPHTEARIMNMEaGTLAKLNTPGELC 487
Cdd:cd05970 309 AGEALNPEVFNTFKEKTGIK-LMEGFGQTETT-LTIATFP--WMEPKPGSMGKPAPGYEIDLIDRE-GRSCEAGEEGEIV 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 488 IR---GYCVML--GYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQE 562
Cdd:cd05970 384 IRtskGKPVGLfgGYYKDAEKTAEVW-HDGYYHTGDAAWMDEDGYLWFVGRTDDLIKSSGYRIGPFEVESALIQHPAVLE 462
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 572872742 563 VQVVGVKDDRMGEEICACIRLKDG---EETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:cd05970 463 CAVTGVPDPIRGQVVKATIVLAKGyepSEELKKELQDHVKKVTAPYKYPRIVEFVDELPKTISGKIRRVEIRER 536
|
|
| PRK05852 |
PRK05852 |
fatty acid--CoA ligase family protein; |
103-633 |
1.28e-46 |
|
fatty acid--CoA ligase family protein;
Pssm-ID: 235625 [Multi-domain] Cd Length: 534 Bit Score: 172.76 E-value: 1.28e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:PRK05852 22 VEVAATRLPEAPALVVTADRIAISYRDLARLVDDLAGQLTRSGLLPGDRVALRMGSNAEFVVALLAASRADLVVVPLDPA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKAlvfpkqfktqqyynVLKQICPEVENAQPGAlksQRLPDLTTVISVDAPLPGTLLLDEVVAAGS 262
Cdd:PRK05852 102 LPIAEQRVRSQAAGARV--------------VLIDADGPHDRAEPTT---RWWPLTVNVGGDSGPSGGTLSVHLDAATEP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 263 T-RQHLDQ-LQynqqflscHDPINIQFTSGTTGSPKGATLSHYNIVNN--SNILGERLKLHEKTpeqlrmILPNPLYHCL 338
Cdd:PRK05852 165 TpATSTPEgLR--------PDDAMIMFTGGTTGLPKMVPWTHANIASSvrAIITGYRLSPRDAT------VAVMPLYHGH 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 339 GSVAGTMMCLMYGATLIL-ASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAP--PE 415
Cdd:PRK05852 231 GLIAALLATLASGGAVLLpARGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERAATEPSGRKPAALRFIRSCSAPltAE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 416 LIRAIINKINMKdLVVAYGTTE--NSPVTFAHFPEDTVEQKAESVGRIMPHTEA--RIMNMEAGTLAKlNTPGELCIRGY 491
Cdd:PRK05852 311 TAQALQTEFAAP-VVCAFGMTEatHQVTTTQIEGIGQTENPVVSTGLVGRSTGAqiRIVGSDGLPLPA-GAVGEVWLRGT 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 492 CVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDD 571
Cdd:PRK05852 389 TVVRGYLGDPTITAANF-TDGWLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPDQ 467
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 572872742 572 RMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK05852 468 LYGEAVAAVIVPRESAPPTAEELVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRRAVAEQ 529
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
281-625 |
1.01e-45 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 174.73 E-value: 1.01e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 281 DPINIQFTSGTTGSPKGATLSHYNIVnnSNIlgerlklhektpEQLRMILPN----------PLYHCLGSVAGTMMCLMY 350
Cdd:PRK08633 783 DTATIIFSSGSEGEPKGVMLSHHNIL--SNI------------EQISDVFNLrnddvilsslPFFHSFGLTVTLWLPLLE 848
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 351 GATLIL-ASPIfNGKKALEAISRERGTFLYGTPTMF-----VDILNQPDFSSYDIstmcggVIAGSPA-PPELIRAIINK 423
Cdd:PRK08633 849 GIKVVYhPDPT-DALGIAKLVAKHRATILLGTPTFLrlylrNKKLHPLMFASLRL------VVAGAEKlKPEVADAFEEK 921
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 424 INmKDLVVAYGTTENSPVTFAHFP----EDTVEQ---KAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLG 496
Cdd:PRK08633 922 FG-IRILEGYGATETSPVASVNLPdvlaADFKRQtgsKEGSVGMPLPGVAVRIVDPETFEELPPGEDGLILIGGPQVMKG 1000
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 497 YWGEPQKTEEAV---DQDKWYWTGDVATMNEQGFCKIVGR----SKdmIirGGENIYPAELEDFFHTHPKVQEVQ--VVG 567
Cdd:PRK08633 1001 YLGDPEKTAEVIkdiDGIGWYVTGDKGHLDEDGFLTITDRysrfAK--I--GGEMVPLGAVEEELAKALGGEEVVfaVTA 1076
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 572872742 568 VKDDRMGEEICACIRLKDGEETTVEEIKAfcKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:PRK08633 1077 VPDEKKGEKLVVLHTCGAEDVEELKRAIK--ESGLPNLWKPSRYFKVEALPLLGSGKL 1132
|
|
| DltA |
cd05945 |
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ... |
107-630 |
4.89e-45 |
|
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes D-alanyl carrier protein ligase DltA and aliphatic beta-amino acid adenylation enzymes IdnL1 and CmiS6. DltA incorporates D-ala in techoic acids in gram-positive bacteria via a two-step process, starting with adenylation of D-alanine that transfers D-alanine to the D-alanyl carrier protein. IdnL1, a short-chain aliphatic beta-amino acid adenylation enzyme, recognizes 3-aminobutanoic acid, and is involved in the synthesis of the macrolactam antibiotic incednine. CmiS6 is a medium-chain beta-amino acid adenylation enzyme that recognizes 3-aminononanoic acid, and is involved in the synthesis of cremimycin, also a macrolactam antibiotic. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341267 [Multi-domain] Cd Length: 449 Bit Score: 166.27 E-value: 4.89e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 107 AQRVPEReaLVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAM 186
Cdd:cd05945 1 AAANPDR--PAVVEGGRTLTYRELKERADALAAALASLGLDAGDPVVVYGHKSPDAIAAFLAALKAGHAYVPLDASSPAE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 187 ELEYVLKKVGCKALVfpkqfktqqyynvlkqicpevenaqpgalksqrlpdlttvisvdaplpgtllldevvAAGstrqh 266
Cdd:cd05945 79 RIREILDAAKPALLI---------------------------------------------------------ADG----- 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 267 ldqlqynqqflscHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhektPEQLRmILPNPLYHCLGSVAGTMM 346
Cdd:cd05945 97 -------------DDNAYIIFTSGSTGRPKGVQISHDNLVSFTNWMLSDFPL----GPGDV-FLNQAPFSFDLSVMDLYP 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 347 CLMYGATLILASP--IFNGKKALEAISRERGTFLYGTPTmFVDILNQ-PDFSSYDISTMCGGVIAGSPAPPELIRAIINK 423
Cdd:cd05945 159 ALASGATLVPVPRdaTADPKQLFRFLAEHGITVWVSTPS-FAAMCLLsPTFTPESLPSLRHFLFCGEVLPHKTARALQQR 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 424 INMKDLVVAYGTTE-NSPVTFAHFPEDTVEQkAESV--GRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGE 500
Cdd:cd05945 238 FPDARIYNTYGPTEaTVAVTYIEVTPEVLDG-YDRLpiGYAKPGAKLVILD-EDGRPVPPGEKGELVISGPSVSKGYLNN 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 501 PQKTEEAVDQDK---WYWTGDVATMNEQGFCKIVGRSKDMI-IRGgeniYPAELED---FFHTHPKVQEVQVVGVKDDRM 573
Cdd:cd05945 316 PEKTAAAFFPDEgqrAYRTGDLVRLEADGLLFYRGRLDFQVkLNG----YRIELEEieaALRQVPGVKEAVVVPKYKGEK 391
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 574 GEEICACIRLKDGEE---TTveEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 630
Cdd:cd05945 392 VTELIAFVVPKPGAEaglTK--AIKAELAERLPPYMIPRRFVYLDELPLNANGKIDRKAL 449
|
|
| MACS_like_4 |
cd05969 |
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ... |
125-631 |
5.53e-45 |
|
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most similar to acetyl-CoA synthetase. Acetyl-CoA synthetase (ACS) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is only present in bacteria.
Pssm-ID: 341273 [Multi-domain] Cd Length: 442 Bit Score: 166.14 E-value: 5.53e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 125 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIIlvsvnpayqameleyvlkkvgckalvfpk 204
Cdd:cd05969 1 YTFAQLKVLSARFANVLKSLGVGKGDRVFVLSPRSPELYFSMLGIGKIGAV----------------------------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 205 qfktqqyynvlkqICPEVENAQPGALKSQrlpdlttvisvdaplpgtLLLDEVVAAGSTRQHLDQLQYNqqflschDPIN 284
Cdd:cd05969 52 -------------ICPLFSAFGPEAIRDR------------------LENSEAKVLITTEELYERTDPE-------DPTL 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 285 IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHektpeqlrmilPNPLYHCL-------GSVAGTMMCLMYGATLILA 357
Cdd:cd05969 94 LHYTSGTTGTPKGVLHVHDAMIFYYFTGKYVLDLH-----------PDDIYWCTadpgwvtGTVYGIWAPWLNGVTNVVY 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 358 SPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDF--SSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGT 435
Cdd:cd05969 163 EGRFDAESWYGIIERVKVTVWYTAPTAIRMLMKEGDElaRKYDLSSLRFIHSVGEPLNPEAIRWGMEVFGVP-IHDTWWQ 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 436 TENSPVTFAHFPEDTVeqKAESVGRIMPHTEARIMNMEAGTLAKlNTPGELCIR-GYCVML-GYWGEPQKTEEAVdQDKW 513
Cdd:cd05969 242 TETGSIMIANYPCMPI--KPGSMGKPLPGVKAAVVDENGNELPP-GTKGILALKpGWPSMFrGIWNDEERYKNSF-IDGW 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 514 YWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVE- 592
Cdd:cd05969 318 YLTGDLAYRDEDGYFWFVGRADDIIKTSGHRVGPFEVESALMEHPAVAEAGVIGKPDPLRGEIIKAFISLKEGFEPSDEl 397
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 572872742 593 --EIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05969 398 keEIINFVRQKLGAHVAPREIEFVDNLPKTRSGKIMRRVLK 438
|
|
| ttLC_FACS_like |
cd05915 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ... |
112-632 |
1.63e-44 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified in Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes an uncharacterized subgroup of FACS.
Pssm-ID: 213283 [Multi-domain] Cd Length: 509 Bit Score: 166.45 E-value: 1.63e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 112 EREALVV---LHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMEL 188
Cdd:cd05915 9 GRKEVVSrlhTGEVHRTTYAEVYQRARRLMGGLRALGVGVGDRVATLGFNHFRHLEAYFAVPGMGAVLHTANPRLSPKEI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 189 EYVLKKVgcKALVFpkqFKTQQYYNVLKQICPEVENAQPGALKSQRLPDLTTVISVDAP-LPGTLLLDEVvaagstrqhl 267
Cdd:cd05915 89 AYILNHA--EDKVL---LFDPNLLPLVEAIRGELKTVQHFVVMDEKAPEGYLAYEEALGeEADPVRVPER---------- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 268 dqlqynqqflschDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEK-TPEQLRMIlpnPLYHCLGSVAgTMM 346
Cdd:cd05915 154 -------------AACGMAYTTGTTGLPKGVVYSHRALVLHSLAASLVDGTALSeKDVVLPVV---PMFHVNAWCL-PYA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 347 CLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDF--SSYDISTMcggVIAGSPAPPELIRAiINKI 424
Cdd:cd05915 217 ATLVGAKQVLPGPRLDPASLVELFDGEGVTFTAGVPTVWLALADYLEStgHRLKTLRR---LVVGGSAAPRSLIA-RFER 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 425 NMKDLVVAYGTTENSPVTFA--------HFPE---------DTVEQKAESVGRIMPHTearimnMEAGTLAKlnTPGELC 487
Cdd:cd05915 293 MGVEVRQGYGLTETSPVVVQnfvkshleSLSEeekltlkakTGLPIPLVRLRVADEEG------RPVPKDGK--ALGEVQ 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 488 IRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVG 567
Cdd:cd05915 365 LKGPWITGGYYGNEEATRSALTPDGFFRTGDIAVWDEEGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPKVKEAAVVA 444
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572872742 568 VKDDRMGEEICACIRLKDGEETTvEEIKAFCKGKISHFK-IPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:cd05915 445 IPHPKWQERPLAVVVPRGEKPTP-EELNEHLLKAGFAKWqLPDAYVFAEEIPRTSAGKFLKRALRE 509
|
|
| LC_FACL_like |
cd05914 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ... |
120-628 |
1.22e-42 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341240 [Multi-domain] Cd Length: 463 Bit Score: 159.92 E-value: 1.22e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 120 HEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLkkvgcka 199
Cdd:cd05914 3 YGGEPLTYKDLADNIAKFALLLKINGVGTGDRVALMGENRPEWGIAFFAIWTYGAIAVPILAEFTADEVHHIL------- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 200 lvfpkqfktqqyynvlkqicpevENAQPGALksqrlpdlttvisvdaplpgtllldevvaagstrqhldqlqynqqFLSC 279
Cdd:cd05914 76 -----------------------NHSEAKAI---------------------------------------------FVSD 87
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 280 HDPIN-IQFTSGTTGSPKGATLSHYNIVNNSNiLGERLKLHEKTPEQLRMIlpnPLYHCLGSVAGTMMCLMYGATLILAS 358
Cdd:cd05914 88 EDDVAlINYTSGTTGNSKGVMLTYRNIVSNVD-GVKEVVLLGKGDKILSIL---PLHHIYPLTFTLLLPLLNGAHVVFLD 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 359 PIFNGKkaLEAISRERGTFLYGTPTMFV-------DILNQPDFS-----------SYDISTMC--------GG-----VI 407
Cdd:cd05914 164 KIPSAK--IIALAFAQVTPTLGVPVPLViekifkmDIIPKLTLKkfkfklakkinNRKIRKLAfkkvheafGGnikefVI 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 408 AGSPAPPElIRAIINKINMKdLVVAYGTTENSPVTFAHFPEDTveqKAESVGRIMPHTEARIMNMEAGTLAklntpGELC 487
Cdd:cd05914 242 GGAKINPD-VEEFLRTIGFP-YTIGYGMTETAPIISYSPPNRI---RLGSAGKVIDGVEVRIDSPDPATGE-----GEII 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 488 IRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRG-GENIYPAELEDFFHTHPKVQEVQVV 566
Cdd:cd05914 312 VRGPNVMKGYYKNPEATAEAFDKDGWFHTGDLGKIDAEGYLYIRGRKKEMIVLSsGKNIYPEEIEAKINNMPFVLESLVV 391
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 572872742 567 gVKDDRM---------GEEICAcIRLKDGEETTVEEIKAFCKGKISHF-KIPKYIVFVTNYPLTISGKIQKF 628
Cdd:cd05914 392 -VQEKKLvalayidpdFLDVKA-LKQRNIIDAIKWEVRDKVNQKVPNYkKISKVKIVKEEFEKTPKGKIKRF 461
|
|
| AA-adenyl-dom |
TIGR01733 |
amino acid adenylation domain; This model represents a domain responsible for the specific ... |
126-565 |
1.74e-42 |
|
amino acid adenylation domain; This model represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalyzed is aa + ATP -> aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called "A-domains" in that context. A-domains are almost invariably followed by "T-domains" (thiolation domains, pfam00550) to which the amino acid adenylate is transferred as a thiol-ester to a bound pantetheine cofactor with the release of AMP (these are also called peptide carrier proteins, or PCPs. When the A-domain does not represent the first module (corresponding to the first amino acid in the product molecule) it is usually preceded by a "C-domain" (condensation domain, pfam00668) which catalyzes the ligation of two amino acid thiol-esters from neighboring modules. This domain is a subset of the AMP-binding domain found in Pfam (pfam00501) which also hits substrate--CoA ligases and luciferases. Sequences scoring in between trusted and noise for this model may be ambiguous as to whether they activate amino acids or other molecules lacking an alpha amino group.
Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 158.20 E-value: 1.74e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 126 TFAQLKEEVDKAASGLLSI-GLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVfpk 204
Cdd:TIGR01733 1 TYRELDERANRLARHLRAAgGVGPGDRVAVLLERSAELVVAILAVLKAGAAYVPLDPAYPAERLAFILEDAGARLLL--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 205 qfkTQQYYnvlkqicpevenaqpgalkSQRLPDLTTVISVDAPLPGTLLLDEVVAAGST-RQHLDQLQYnqqflschdpi 283
Cdd:TIGR01733 78 ---TDSAL-------------------ASRLAGLVLPVILLDPLELAALDDAPAPPPPDaPSGPDDLAY----------- 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 284 nIQFTSGTTGSPKGATLSHYNIVNNSNILGERLklhEKTPEQlRMILPNPlYHCLGSVAGTMMCLMYGATLILASP--IF 361
Cdd:TIGR01733 125 -VIYTSGSTGRPKGVVVTHRSLVNLLAWLARRY---GLDPDD-RVLQFAS-LSFDASVEEIFGALLAGATLVVPPEdeER 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 362 NGKKALEAISRERG-TFLYGTPTMFVDILNQPDFSSYDISTMCggvIAGSPAPPELIRAIINKINMKDLVVAYGTTENSP 440
Cdd:TIGR01733 199 DDAALLAALIAEHPvTVLNLTPSLLALLAAALPPALASLRLVI---LGGEALTPALVDRWRARGPGARLINLYGPTETTV 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 441 VTFAHFPEDTVEQKAESV--GRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEE--------AVDQ 510
Cdd:TIGR01733 276 WSTATLVDPDDAPRESPVpiGRPLANTRLYVLD-DDLRPVPVGVVGELYIGGPGVARGYLNRPELTAErfvpdpfaGGDG 354
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 572872742 511 DKWYWTGDVATMNEQGFCKIVGRSKDMI-IRgGENIYPAELEDFFHTHPKVQEVQV 565
Cdd:TIGR01733 355 ARLYRTGDLVRYLPDGNLEFLGRIDDQVkIR-GYRIELGEIEAALLRHPGVREAVV 409
|
|
| PRK13390 |
PRK13390 |
acyl-CoA synthetase; Provisional |
105-631 |
4.36e-42 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 139538 [Multi-domain] Cd Length: 501 Bit Score: 159.40 E-value: 4.36e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 105 TTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQ 184
Cdd:PRK13390 5 THAQIAPDRPAVIVAETGEQVSYRQLDDDSAALARVLYDAGLRTGDVVALLSDNSPEALVVLWAALRSGLYITAINHHLT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 185 AMELEYVLKKVGCKALVfpkqfktqqyynvlkqicpevENAQPGALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAGSTR 264
Cdd:PRK13390 85 APEADYIVGDSGARVLV---------------------ASAALDGLAAKVGADLPLRLSFGGEIDGFGSFEAALAGAGPR 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 265 qhLDQLQYNQQFLschdpiniqFTSGTTGSPKG--ATLSHYNIVNNSN-ILGERLKLHEKTPEQLrMILPNPLYHclgsV 341
Cdd:PRK13390 144 --LTEQPCGAVML---------YSSGTTGFPKGiqPDLPGRDVDAPGDpIVAIARAFYDISESDI-YYSSAPIYH----A 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 342 AGTMMCLM---YGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPD--FSSYDISTMCGGVIAGSPAPPEL 416
Cdd:PRK13390 208 APLRWCSMvhaLGGTVVLAKR-FDAQATLGHVERYRITVTQMVPTMFVRLLKLDAdvRTRYDVSSLRAVIHAAAPCPVDV 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 417 IRAIINKINmKDLVVAYGTTENSPVTFAHFPEDTVEQKaeSVGRIMPHT----EARIMNMEAGTLaklntpGELCIRGYC 492
Cdd:PRK13390 287 KHAMIDWLG-PIVYEYYSSTEAHGMTFIDSPDWLAHPG--SVGRSVLGDlhicDDDGNELPAGRI------GTVYFERDR 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 493 VMLGYWGEPQKTEEAVDQDKWYWT--GDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKD 570
Cdd:PRK13390 358 LPFRYLNDPEKTAAAQHPAHPFWTtvGDLGSVDEDGYLYLADRKSFMIISGGVNIYPQETENALTMHPAVHDVAVIGVPD 437
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 572872742 571 DRMGEEICACIRLK---DGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:PRK13390 438 PEMGEQVKAVIQLVegiRGSDELARELIDYTRSRIAHYKAPRSVEFVDELPRTPTGKLVKGLLR 501
|
|
| LC_FACS_like |
cd17640 |
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA ... |
123-574 |
5.24e-41 |
|
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA synthetases, including an Arabidopsis gene At4g14070 that plays a role in activation and elongation of exogenous fatty acids. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341295 [Multi-domain] Cd Length: 468 Bit Score: 155.59 E-value: 5.24e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 123 VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVf 202
Cdd:cd17640 4 KRITYKDLYQEILDFAAGLRSLGVKAGEKVALFADNSPRWLIADQGIMALGAVDVVRGSDSSVEELLYILNHSESVALV- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 203 pkqfktqqyynvlkqicpeVENAQPgalksqrlpDLTTVIsvdaplpgtllldevvaagstrqhldqlqynqqflschdp 282
Cdd:cd17640 83 -------------------VENDSD---------DLATII---------------------------------------- 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 283 iniqFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHC--------LGSVAGTMMC------- 347
Cdd:cd17640 95 ----YTSGTTGNPKGVMLTHANLLHQIRSLSDIVPPQPGD----RFLSILPIWHSyersaeyfIFACGCSQAYtsirtlk 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 348 ---LMYGATLILASP-----IFNG-KKALEAISRER----GTFLYGTPTMFVdilnqpdfssydistmcggvIAGSPAPP 414
Cdd:cd17640 167 ddlKRVKPHYIVSVPrlwesLYSGiQKQVSKSSPIKqflfLFFLSGGIFKFG--------------------ISGGGALP 226
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 415 ELIRAIINKINMKdLVVAYGTTENSPVTFAHFPEDTVeqkAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVM 494
Cdd:cd17640 227 PHVDTFFEAIGIE-VLNGYGLTETSPVVSARRLKCNV---RGSVGRPLPGTEIKIVDPEGNVVLPPGEKGIVWVRGPQVM 302
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 495 LGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMII-RGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRM 573
Cdd:cd17640 303 KGYYKNPEATSKVLDSDGWFNTGDLGWLTCGGELVLTGRAKDTIVlSNGENVEPQPIEEALMRSPFIEQIMVVGQDQKRL 382
|
.
gi 572872742 574 G 574
Cdd:cd17640 383 G 383
|
|
| A_NRPS_Ta1_like |
cd12116 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ... |
111-625 |
5.79e-41 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the myxovirescin (TA) antibiotic biosynthetic gene in Myxococcus xanthus; TA production plays a role in predation. It also includes the salinosporamide A polyketide synthase which is involved in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity.
Pssm-ID: 341281 [Multi-domain] Cd Length: 470 Bit Score: 155.53 E-value: 5.79e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 111 PEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEY 190
Cdd:cd12116 1 PDATAVR--DDDRSLSYAELDERANRLAARLRARGVGPGDRVAVYLPRSARLVAAMLAVLKAGAAYVPLDPDYPADRLRY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 191 VLkkvgckalvfpkqfktqqyynvlkqicpevENAQPGALksqrLPDLTTVISVDAPLPGTLLLDEVVAAGSTRQHLDQl 270
Cdd:cd12116 79 IL------------------------------EDAEPALV----LTDDALPDRLPAGLPVLLLALAAAAAAPAAPRTPV- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 271 qynqqflSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQ--------------LRMILPnplyh 336
Cdd:cd12116 124 -------SPDDLAYVIYTSGSTGRPKGVVVSHRNLVNFLHSMRERLGL---GPGDrllavttyafdislLELLLP----- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 337 clgsvagtmmcLMYGATLILASP--IFNGKKALEAISRERGTFLYGTPT---MFVDILNQPDFSsydISTMCGgviaGSP 411
Cdd:cd12116 189 -----------LLAGARVVIAPRetQRDPEALARLIEAHSITVMQATPAtwrMLLDAGWQGRAG---LTALCG----GEA 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 412 APPELIRAIINKI----NMkdlvvaYGTTENSPVTFAHFPEDtvEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELC 487
Cdd:cd12116 251 LPPDLAARLLSRVgslwNL------YGPTETTIWSTAARVTA--AAGPIPIGRPLANTQVYVLD-AALRPVPPGVPGELY 321
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 488 IRGYCVMLGYWGEPQKTEEAVDQD-------KWYWTGDVATMNEQGFCKIVGRSKDMI-IRgGENIYPAELEDFFHTHPK 559
Cdd:cd12116 322 IGGDGVAQGYLGRPALTAERFVPDpfagpgsRLYRTGDLVRRRADGRLEYLGRADGQVkIR-GHRIELGEIEAALAAHPG 400
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572872742 560 VQEVQVVgVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:cd12116 401 VAQAAVV-VREDGGDRRLVAYVVLKAGAAPDAAALRAHLRATLPAYMVPSAFVRLDALPLTANGKL 465
|
|
| PRK04319 |
PRK04319 |
acetyl-CoA synthetase; Provisional |
120-640 |
2.57e-40 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 235279 [Multi-domain] Cd Length: 570 Bit Score: 155.44 E-value: 2.57e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 120 HEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNS---YAWVLmqlATAQAGIIlvsVNPAYQAMELEYV---LK 193
Cdd:PRK04319 69 SRKEKYTYKELKELSNKFANVLKELGVEKGDRVFIFMPRIpelYFALL---GALKNGAI---VGPLFEAFMEEAVrdrLE 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 194 KVGCKALVfpkqfKTQQYYnvlkqicpevenaqpGALKSQRLPDLTTVISVDAP---LPGTLLLDEVVAAGSTrqhldql 270
Cdd:PRK04319 143 DSEAKVLI-----TTPALL---------------ERKPADDLPSLKHVLLVGEDveeGPGTLDFNALMEQASD------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 271 QYNQQFLSCHDPINIQFTSGTTGSPKG------ATLSHYnivnnsnILGER-LKLHektpeqlrmilPNPLYHCL---GS 340
Cdd:PRK04319 196 EFDIEWTDREDGAILHYTSGSTGKPKGvlhvhnAMLQHY-------QTGKYvLDLH-----------EDDVYWCTadpGW 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 341 VAGT----MMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMF-------VDILNQPDFSS--YDISTmcggvi 407
Cdd:PRK04319 258 VTGTsygiFAPWLNGATNVIDGGRFSPERWYRILEDYKVTVWYTAPTAIrmlmgagDDLVKKYDLSSlrHILSV------ 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 408 aGSPAPPELIRAiinkiNMKdlvvAYG--------TTENSPVTFAHFPedTVEQKAESVGRIMPHTEARIMNMEAGTLAK 479
Cdd:PRK04319 332 -GEPLNPEVVRW-----GMK----VFGlpihdnwwMTETGGIMIANYP--AMDIKPGSMGKPLPGIEAAIVDDQGNELPP 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 480 lNTPGELCIR-GYCVML-GYWGEPQKTEEAVDQDkWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTH 557
Cdd:PRK04319 400 -NRMGNLAIKkGWPSMMrGIWNNPEKYESYFAGD-WYVSGDSAYMDEDGYFWFQGRVDDVIKTSGERVGPFEVESKLMEH 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 558 PKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVE---EIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK--FKLRE 632
Cdd:PRK04319 478 PAVAEAGVIGKPDPVRGEIIKAFVALRPGYEPSEElkeEIRGFVKKGLGAHAAPREIEFKDKLPKTRSGKIMRrvLKAWE 557
|
....*...
gi 572872742 633 qmerhLNL 640
Cdd:PRK04319 558 -----LGL 560
|
|
| MACS_euk |
cd05928 |
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ... |
121-633 |
5.54e-40 |
|
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes. MACS enzymes are localized to mitochondria. Two murine MACS family proteins are found in liver and kidney. In rodents, a MACS member is detected particularly in the olfactory epithelium and is called O-MACS. O-MACS demonstrates substrate preference for the fatty acid lengths of C6-C12.
Pssm-ID: 341251 [Multi-domain] Cd Length: 530 Bit Score: 153.78 E-value: 5.54e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 121 EDVRLTFAQLKEEVDKAASGLL-SIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKA 199
Cdd:cd05928 38 DEVKWSFRELGSLSRKAANVLSgACGLQRGDRVAVILPRVPEWWLVNVACIRTGLVFIPGTIQLTAKDILYRLQASKAKC 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 200 LVfpkqfktqqyynVLKQICPEVEnaqpgALKSQrLPDLTTVISV-DAPLPGTLLLDEVVAAGSTRQHLDQLQYNqqfls 278
Cdd:cd05928 118 IV------------TSDELAPEVD-----SVASE-CPSLKTKLLVsEKSRDGWLNFKELLNEASTEHHCVETGSQ----- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 279 chDPINIQFTSGTTGSPKGATLSHynivnnsNILGERLKLHEKtpeQLRMILPNPLYHCLG------SVAGTMMC-LMYG 351
Cdd:cd05928 175 --EPMAIYFTSGTTGSPKMAEHSH-------SSLGLGLKVNGR---YWLDLTASDIMWNTSdtgwikSAWSSLFEpWIQG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 352 ATLILAS-PIFNGKKALEAISRERGTFLYGTPTMFvDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMkDLV 430
Cdd:cd05928 243 ACVFVHHlPRFDPLVILKTLSSYPITTFCGAPTVY-RMLVQQDLSSYKFPSLQHCVTGGEPLNPEVLEKWKAQTGL-DIY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 431 VAYGTTEnSPVTFAHFpeDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIR-----GYCVMLGYWGEPQKTE 505
Cdd:cd05928 321 EGYGQTE-TGLICANF--KGMKIKPGSMGKASPPYDVQIID-DNGNVLPPGTEGDIGIRvkpirPFGLFSGYVDNPEKTA 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 506 eAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRL-- 583
Cdd:cd05928 397 -ATIRGDFYLTGDRGIMDEDGYFWFMGRADDVINSSGYRIGPFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFVVLap 475
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 572872742 584 ----KDGEETTvEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:cd05928 476 qflsHDPEQLT-KELQQHVKSVTAPYKYPRKVEFVQELPKTVTGKIQRNELRDK 528
|
|
| PtmA |
cd17636 |
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, ... |
281-623 |
1.29e-39 |
|
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341291 [Multi-domain] Cd Length: 331 Bit Score: 148.22 E-value: 1.29e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 281 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHclgsvAGTMMCLMygATLILAS-- 358
Cdd:cd17636 1 DPVLAIYTAAFSGRPNGALLSHQALLAQALVLAVLQAIDEGT----VFLNSGPLFH-----IGTLMFTL--ATFHAGGtn 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 359 ---PIFNGKKALEAISRER--GTFLYGtPTMF----VDILNQPDFSS-YDISTMCGGVIAGSPAPPELIRAiinkinmkd 428
Cdd:cd17636 70 vfvRRVDAEEVLELIEAERctHAFLLP-PTIDqiveLNADGLYDLSSlRSSPAAPEWNDMATVDTSPWGRK--------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 429 lVVAYGTTENS-PVTFAHFPEDTVEqkaeSVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEA 507
Cdd:cd17636 140 -PGGYGQTEVMgLATFAALGGGAIG----GAGRPSPLVQVRILD-EDGREVPDGEVGEIVARGPTVMAGYWNRPEVNARR 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 508 VdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGE 587
Cdd:cd17636 214 T-RGGWHHTNDLGRREPDGSLSFVGPKTRMIKSGAENIYPAEVERCLRQHPAVADAAVIGVPDPRWAQSVKAIVVLKPGA 292
|
330 340 350
....*....|....*....|....*....|....*.
gi 572872742 588 ETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISG 623
Cdd:cd17636 293 SVTEAELIEHCRARIASYKKPKSVEFADALPRTAGG 328
|
|
| FAAL |
cd05931 |
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ... |
107-636 |
6.49e-39 |
|
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.
Pssm-ID: 341254 [Multi-domain] Cd Length: 547 Bit Score: 150.85 E-value: 6.49e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 107 AQRVPEREALVVLH----EDVRLTFAQLKEEVDKAASGLLSIGLCkGDRLGMWGPNSYAWVLMQLATAQAGIILVSV--- 179
Cdd:cd05931 3 AAARPDRPAYTFLDdeggREETLTYAELDRRARAIAARLQAVGKP-GDRVLLLAPPGLDFVAAFLGCLYAGAIAVPLppp 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 180 NPAYQAMELEYVLKKVGCKALVfpkqfktqqyynvlkqICPEVENAQPGALKSQRLPDLTTVISVDaplpgtlLLDEVVA 259
Cdd:cd05931 82 TPGRHAERLAAILADAGPRVVL----------------TTAAALAAVRAFAASRPAAGTPRLLVVD-------LLPDTSA 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 260 AGSTRQHLDQlqynqqflscHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLG 339
Cdd:cd05931 139 ADWPPPSPDP----------DDIAYLQYTSGSTGTPKGVVVTHRNLLANVRQIRRAYGLDPGD----VVVSWLPLYHDMG 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 340 SVAGTMMCLMYGATLILASPI-FNGKKA--LEAISRERGTFLYGtPTmF-----VDILNQPDFSSYDISTMCGGVIAGSP 411
Cdd:cd05931 205 LIGGLLTPLYSGGPSVLMSPAaFLRRPLrwLRLISRYRATISAA-PN-FaydlcVRRVRDEDLEGLDLSSWRVALNGAEP 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 412 APPELIRAIINKI---NMKDLVV--AYG----------TTENSPVTFAHFPEDTVEQKAE-------------SVGRIMP 463
Cdd:cd05931 283 VRPATLRRFAEAFapfGFRPEAFrpSYGlaeatlfvsgGPPGTGPVVLRVDRDALAGRAVavaaddpaarelvSCGRPLP 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 464 HTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEE------AVDQDKWYWTGDVATMNEqGFCKIVGRSKDM 537
Cdd:cd05931 363 DQEVRIVDPETGRELPDGEVGEIWVRGPSVASGYWGRPEATAEtfgalaATDEGGWLRTGDLGFLHD-GELYITGRLKDL 441
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 538 IIRGGENIYPAELEDF-FHTHPKVQE--VQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKIS-HFKI-PKYIV 612
Cdd:cd05931 442 IIVRGRNHYPQDIEATaEEAHPALRPgcVAAFSVPDDGEERLVVVAEVERGADPADLAAIAAAIRAAVArEHGVaPADVV 521
|
570 580
....*....|....*....|....*.
gi 572872742 613 FVTN--YPLTISGKIQKFKLREQMER 636
Cdd:cd05931 522 LVRPgsIPRTSSGKIQRRACRAAYLD 547
|
|
| FACL_like_5 |
cd05924 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
279-624 |
1.01e-37 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341248 [Multi-domain] Cd Length: 364 Bit Score: 143.68 E-value: 1.01e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 279 CHDPINIQFTSGTTGSPKGATLSHYNIVNNS---------NILGERLKLHEKTP-EQLRMILPNPLYHCLGSVAGtMMCL 348
Cdd:cd05924 2 SADDLYILYTGGTTGMPKGVMWRQEDIFRMLmggadfgtgEFTPSEDAHKAAAAaAGTVMFPAPPLMHGTGSWTA-FGGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 349 MYGATLILASPIFNGKKALEAISRERGTFLygtpTMFVDILNQP------DFSSYDISTMCGGVIAGSPAPPELIRAIIN 422
Cdd:cd05924 81 LGGQTVVLPDDRFDPEEVWRTIEKHKVTSM----TIVGDAMARPlidalrDAGPYDLSSLFAISSGGALLSPEVKQGLLE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 423 KINMKDLVVAYGTTENSPVTFAHfpedTVEQKAESVGRIMPHTEARIMNMEAGTLAK-LNTPGELCIRGYcVMLGYWGEP 501
Cdd:cd05924 157 LVPNITLVDAFGSSETGFTGSGH----SAGSGPETGPFTRANPDTVVLDDDGRVVPPgSGGVGWIARRGH-IPLGYYGDE 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 502 QKTEEA---VDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEIC 578
Cdd:cd05924 232 AKTAETfpeVDGVRYAVPGDRATVEADGTVTLLGRGSVCINTGGEKVFPEEVEEALKSHPAVYDVLVVGRPDERWGQEVV 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 572872742 579 ACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGK 624
Cdd:cd05924 312 AVVQLREGAGVDLEELREHCRTRIARYKLPKQVVFVDEIERSPAGK 357
|
|
| A_NRPS_VisG_like |
cd17651 |
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ... |
107-625 |
8.05e-37 |
|
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes virginiamycin S synthetase (VisG) in Streptomyces virginiae; VisG is involved in virginiamycin S (VS) biosynthesis as the provider of an L-pheGly molecule, a highly specific substrate for the last condensation step by VisF. This family also includes linear gramicidin synthetase B (LgrB) in Brevibacillus brevis. Substrate specificity analysis using residues of the substrate-binding pockets of all 16 adenylation domains has shown good agreement of the substrate amino acids predicted with the sequence of linear gramicidin. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341306 [Multi-domain] Cd Length: 491 Bit Score: 144.02 E-value: 8.05e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 107 AQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAM 186
Cdd:cd17651 5 AARTPDAPALV--AEGRRLTYAELDRRANRLAHRLRARGVGPGDLVALCARRSAELVVALLAILKAGAAYVPLDPAYPAE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 187 ELEYVLKKVGCKALVfpkqfkTQqyynvlkqicPEVENAQPgalksqrlPDLTTVISVDAPLPGTLLLDEVVAAgstrqh 266
Cdd:cd17651 83 RLAFMLADAGPVLVL------TH----------PALAGELA--------VELVAVTLLDQPGAAAGADAEPDPA------ 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 267 ldqlqynqqfLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLrmilpnplYHCLG---SVAG 343
Cdd:cd17651 133 ----------LDADDLAYVIYTSGSTGRPKGVVMPHRSLANLVAWQARASSLGPGARTLQ--------FAGLGfdvSVQE 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 344 TMMCLMYGATLILASP-IFNGKKALEAISRERG---TFLygtPTMFVD-ILNQPDFSSYDISTMCGGVIAGSPAPP-ELI 417
Cdd:cd17651 195 IFSTLCAGATLVLPPEeVRTDPPALAAWLDEQRisrVFL---PTVALRaLAEHGRPLGVRLAALRYLLTGGEQLVLtEDL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 418 RAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAE-SVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLG 496
Cdd:cd17651 272 REFCAGLPGLRLHNHYGPTETHVVTALSLPGDPAAWPAPpPIGRPIDNTRVYVLD-AALRPVPPGVPGELYIGGAGLARG 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 497 YWGEPQKTEEAVDQDKW------YWTGDVATMNEQGFCKIVGRSKDMI-IRGgENIYPAELEDFFHTHPKVQEVQVVGVK 569
Cdd:cd17651 351 YLNRPELTAERFVPDPFvpgarmYRTGDLARWLPDGELEFLGRADDQVkIRG-FRIELGEIEAALARHPGVREAVVLARE 429
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 572872742 570 DDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:cd17651 430 DRPGEKRLVAYVVGDPEAPVDAAELRAALATHLPEYMVPSAFVLLDALPLTPNGKL 485
|
|
| A_NRPS_Sfm_like |
cd12115 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ... |
103-630 |
8.60e-37 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the saframycin A gene cluster from Streptomyces lavendulae which implicates the NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. It also includes saframycin Mx1 produced by Myxococcus xanthus NRPS.
Pssm-ID: 341280 [Multi-domain] Cd Length: 447 Bit Score: 143.23 E-value: 8.60e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVVlhEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:cd12115 5 VEAQAARTPDAIALVC--GDESLTYAELNRRANRLAARLRAAGVGPESRVGVCLERTPDLVVALLAVLKAGAAYVPLDPA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKALvfpkqfktqqyynvlkqicpevenaqpgalksqrlpdLTTvisvdaplpgtllldevvaags 262
Cdd:cd12115 83 YPPERLRFILEDAQARLV-------------------------------------LTD---------------------- 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 263 trqhLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNnsnILgeRLKLHEKTPEQLRMILpnplyhclgsvA 342
Cdd:cd12115 104 ----PDDLAY------------VIYTSGSTGRPKGVAIEHRNAAA---FL--QWAAAAFSAEELAGVL-----------A 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 343 GTMMC-----------LMYGATLILASPIFngkkALEAISRERGTFLYGT-PTMFVDILNQPDFSSyDISTMCggvIAGS 410
Cdd:cd12115 152 STSICfdlsvfelfgpLATGGKVVLADNVL----ALPDLPAAAEVTLINTvPSAAAELLRHDALPA-SVRVVN---LAGE 223
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 411 PAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHfPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRG 490
Cdd:cd12115 224 PLPRDLVQRLYARLQVERVVNLYGPSEDTTYSTVA-PVPPGASGEVSIGRPLANTQAYVLD-RALQPVPLGVPGELYIGG 301
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 491 YCVMLGYWGEPQKTEEAVDQD------KWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQ 564
Cdd:cd12115 302 AGVARGYLGRPGLTAERFLPDpfgpgaRLYRTGDLVRWRPDGLLEFLGRADNQVKVRGFRIELGEIEAALRSIPGVREAV 381
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572872742 565 VVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 630
Cdd:cd12115 382 VVAIGDAAGERRLVAYIVAEPGAAGLVEDLRRHLGTRLPAYMVPSRFVRLDALPLTPNGKIDRSAL 447
|
|
| PRK07787 |
PRK07787 |
acyl-CoA synthetase; Validated |
112-631 |
1.16e-36 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236096 [Multi-domain] Cd Length: 471 Bit Score: 143.21 E-value: 1.16e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 112 EREALVVlhEDVRLTFAQLKeevdkAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYV 191
Cdd:PRK07787 15 IADAVRI--GGRVLSRSDLA-----GAATAVAERVAGARRVAVLATPTLATVLAVVGALIAGVPVVPVPPDSGVAERRHI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 192 LKKVGCKALVFPKqfktqqyynvlkqicpevenaqPGALKSqrLPdlttVISVDAPLPGTLLLDEVVAAGstrqhldqlq 271
Cdd:PRK07787 88 LADSGAQAWLGPA----------------------PDDPAG--LP----HVPVRLHARSWHRYPEPDPDA---------- 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 272 ynqqflschdPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLklhEKTPEQLrMILPNPLYHCLGSVAGTMMCLMYG 351
Cdd:PRK07787 130 ----------PALIVYTSGTTGPPKGVVLSRRAIAADLDALAEAW---QWTADDV-LVHGLPLFHVHGLVLGVLGPLRIG 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 352 ATLIlaspiFNGKKALEAISRE---RGTFLYGTPTMFVDILNQPD----FSSYDIstmcggVIAGSPAPPELIRAIINKI 424
Cdd:PRK07787 196 NRFV-----HTGRPTPEAYAQAlseGGTLYFGVPTVWSRIAADPEaaraLRGARL------LVSGSAALPVPVFDRLAAL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 425 NMKDLVVAYGTTENSPVTFAHFpeDTvEQKAESVGRIMPHTEARIMNmEAGTLAKLN--TPGELCIRGYCVMLGYWGEPQ 502
Cdd:PRK07787 265 TGHRPVERYGMTETLITLSTRA--DG-ERRPGWVGLPLAGVETRLVD-EDGGPVPHDgeTVGELQVRGPTLFDGYLNRPD 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 503 KTEEAVDQDKWYWTGDVATMNEQGFCKIVGR-SKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACI 581
Cdd:PRK07787 341 ATAAAFTADGWFRTGDVAVVDPDGMHRIVGReSTDLIKSGGYRIGAGEIETALLGHPGVREAAVVGVPDDDLGQRIVAYV 420
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 572872742 582 rlKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:PRK07787 421 --VGADDVAADELIDFVAQQLSVHKRPREVRFVDALPRNAMGKVLKKQLL 468
|
|
| EntF |
COG1020 |
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ... |
97-597 |
1.49e-36 |
|
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 146.93 E-value: 1.49e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 97 KTVGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIIL 176
Cdd:COG1020 476 ATLHELFEAQAARTPDAVAVV--FGDQSLTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAGAAY 553
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 177 VSVNPAYQAMELEYVLKKVGCKALVfpkqfkTQQyynvlkqicpevenaqpgALKsQRLPDLT-TVISVDAPLpgtlLLD 255
Cdd:COG1020 554 VPLDPAYPAERLAYMLEDAGARLVL------TQS------------------ALA-ARLPELGvPVLALDALA----LAA 604
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 256 EVVAAGSTRQHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEktpeQLRMilpnPLY 335
Cdd:COG1020 605 EPATNPPVPVTPDDLAY------------VIYTSGSTGRPKGVMVEHRALVNLLAWMQRRYGLGP----GDRV----LQF 664
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 336 HCLG---SVAGTMMCLMYGATLILASP--IFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMcggVIAGS 410
Cdd:COG1020 665 ASLSfdaSVWEIFGALLSGATLVLAPPeaRRDPAALAELLARHRVTVLNLTPSLLRALLDAAPEALPSLRLV---LVGGE 741
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 411 PAPPELIRAIINKINMKDLVVAYGTTENSpVTFAHFPEDTVEQKAESV--GRIMPHTEARIMNmEAGTLAKLNTPGELCI 488
Cdd:COG1020 742 ALPPELVRRWRARLPGARLVNLYGPTETT-VDSTYYEVTPPDADGGSVpiGRPIANTRVYVLD-AHLQPVPVGVPGELYI 819
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 489 RGYCVMLGYWGEPQKTEEA-------VDQDKWYWTGDVATMNEQG---FckiVGRSKDMI-IRGgeniY---PAELEDFF 554
Cdd:COG1020 820 GGAGLARGYLNRPELTAERfvadpfgFPGARLYRTGDLARWLPDGnleF---LGRADDQVkIRG----FrieLGEIEAAL 892
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 572872742 555 HTHPKVQEVqVVGVKDDRMGEE-ICACIRLKDGEETTVEEIKAF 597
Cdd:COG1020 893 LQHPGVREA-VVVAREDAPGDKrLVAYVVPEAGAAAAAALLRLA 935
|
|
| FADD10 |
cd17635 |
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ... |
281-627 |
2.35e-36 |
|
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain fatty acid CoA ligases, including FadD10 which is involved in the synthesis of a virulence-related lipopeptide. FadD10 is a fatty acyl-AMP ligase (FAAL) that transfers fatty acids to an acyl carrier protein. Structures of FadD10 in apo- and complexed form with dodecanoyl-AMP, show a novel open conformation, facilitated by its unique inter-domain and intermolecular interactions, which is critical for the enzyme to carry out the acyl transfer onto the acyl carrier protein (Rv0100) rather than coenzyme A.
Pssm-ID: 341290 [Multi-domain] Cd Length: 340 Bit Score: 139.32 E-value: 2.35e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 281 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKlhEKTPEQLrMILPNPLYHCLGSvAGTMMCLMYGATLILASPI 360
Cdd:cd17635 2 DPLAVIFTSGTTGEPKAVLLANKTFFAVPDILQKEGL--NWVVGDV-TYLPLPATHIGGL-WWILTCLIHGGLCVTGGEN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 361 FNGKKALEAISRERGTFLYGTPTMFVDILNQ-PDFSSYDISTMCggVIAGSPAPPELIRAIINKINMKDLVVAYGTTENS 439
Cdd:cd17635 78 TTYKSLFKILTTNAVTTTCLVPTLLSKLVSElKSANATVPSLRL--IGYGGSRAIAADVRFIEATGLTNTAQVYGLSETG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 440 PVTFAHFPEDTVEqkAESVGRIMPHTEARIMNMEaGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEaVDQDKWYWTGDV 519
Cdd:cd17635 156 TALCLPTDDDSIE--INAVGRPYPGVDVYLAATD-GIAGPSASFGTIWIKSPANMLGYWNNPERTAE-VLIDGWVNTGDL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 520 ATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIrLKDGE--ETTVEEIKAF 597
Cdd:cd17635 232 GERREDGFLFITGRSSESINCGGVKIAPDEVERIAEGVSGVQECACYEISDEEFGELVGLAV-VASAEldENAIRALKHT 310
|
330 340 350
....*....|....*....|....*....|
gi 572872742 598 CKGKISHFKIPKYIVFVTNYPLTISGKIQK 627
Cdd:cd17635 311 IRRELEPYARPSTIVIVTDIPRTQSGKVKR 340
|
|
| MACS_like_3 |
cd05971 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
124-631 |
2.97e-36 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341275 [Multi-domain] Cd Length: 439 Bit Score: 141.42 E-value: 2.97e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 124 RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVfp 203
Cdd:cd05971 6 KVTFKELKTASNRFANVLKEIGLEKGDRVGVFLSQGPECAIAHIAILRSGAIAVPLFALFGPEALEYRLSNSGASALV-- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 204 kqfktqqyynvlkqicpevenaqpgalksqrlpdlttvisVDAPlpgtllldevvaagstrqhldqlqynqqflscHDPI 283
Cdd:cd05971 84 ----------------------------------------TDGS--------------------------------DDPA 91
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 284 NIQFTSGTTGSPKGATLSHYNIVNNsniLGERLKLHEKTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILA--SPIF 361
Cdd:cd05971 92 LIIYTSGTTGPPKGALHAHRVLLGH---LPGVQFPFNLFPRDGDLYWTPADWAWIGGLLDVLLPSLYFGVPVLAhrMTKF 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 362 NGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELI----RAIINKINMkdlvvAYGTTE 437
Cdd:cd05971 169 DPKAALDLMSRYGVTTAFLPPTALKMMRQQGEQLKHAQVKLRAIATGGESLGEELLgwarEQFGVEVNE-----FYGQTE 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 438 ------NSPVTFahfpedtvEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYC--VMLGYWGEPQKTEEAVD 509
Cdd:cd05971 244 cnlvigNCSALF--------PIKPGSMGKPIPGHRVAIVD-DNGTPLPPGEVGEIAVELPDpvAFLGYWNNPSATEKKMA 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 510 QDkWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEET 589
Cdd:cd05971 315 GD-WLLTGDLGRKDSDGYFWYVGRDDDVITSSGYRIGPAEIEECLLKHPAVLMAAVVGIPDPIRGEIVKAFVVLNPGETP 393
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 572872742 590 T---VEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05971 394 SdalAREIQELVKTRLAAHEYPREIEFVNELPRTATGKIRRRELR 438
|
|
| A_NRPS_AB3403-like |
cd17646 |
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ... |
103-625 |
3.34e-36 |
|
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 142.03 E-value: 3.34e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:cd17646 4 VAEQAARTPDAPAVV--DEGRTLTYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAGAAYLPLDPG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKALVfpkqfktqqyynvlkqicpeVENAQPGALKsqRLPDLTTVISVDAPLPGTLLLDEVVaags 262
Cdd:cd17646 82 YPADRLAYMLADAGPAVVL--------------------TTADLAARLP--AGGDVALLGDEALAAPPATPPLVPP---- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 263 trqHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNsnIL----------GERLkLHeKTPeqlrmilpn 332
Cdd:cd17646 136 ---RPDNLAY------------VIYTSGSTGRPKGVMVTHAGIVNR--LLwmqdeyplgpGDRV-LQ-KTP--------- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 333 plyhcLG---SVAGTMMCLMYGATLILASPIFNGKKA--LEAISRERGTFLYGTPTMFVDILNQPDFSSydistmCGG-- 405
Cdd:cd17646 188 -----LSfdvSVWELFWPLVAGARLVVARPGGHRDPAylAALIREHGVTTCHFVPSMLRVFLAEPAAGS------CASlr 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 406 --VIAGSPAPPELIRAIINKINMKdLVVAYGTTENSpVTFAHFP-EDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNT 482
Cdd:cd17646 257 rvFCSGEALPPELAARFLALPGAE-LHNLYGPTEAA-IDVTHWPvRGPAETPSVPIGRPVPNTRLYVLD-DALRPVPVGV 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 483 PGELCIRGYCVMLGYWGEPQKTEEAVDQD------KWYWTGDVATMNEQGFCKIVGRSKDMI-IRgGENIYPAELEDFFH 555
Cdd:cd17646 334 PGELYLGGVQLARGYLGRPALTAERFVPDpfgpgsRMYRTGDLARWRPDGALEFLGRSDDQVkIR-GFRVEPGEIEAALA 412
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572872742 556 THPKVQEVQVVGVKDDRMGEEICA-CIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:cd17646 413 AHPAVTHAVVVARAAPAGAARLVGyVVPAAGAAGPDTAALRAHLAERLPEYMVPAAFVVLDALPLTANGKL 483
|
|
| PLN02574 |
PLN02574 |
4-coumarate--CoA ligase-like |
125-638 |
1.02e-35 |
|
4-coumarate--CoA ligase-like
Pssm-ID: 215312 [Multi-domain] Cd Length: 560 Bit Score: 141.90 E-value: 1.02e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 125 LTFAQLKEEVDKAASGLL-SIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAyqAMELEYVLKKVGCK-ALVF 202
Cdd:PLN02574 67 ISYSELQPLVKSMAAGLYhVMGVRQGDVVLLLLPNSVYFPVIFLAVLSLGGIVTTMNPS--SSLGEIKKRVVDCSvGLAF 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 203 PkqfktqqyynvlkqicpEVENAqpGALKSQRLPdlttVISVdaplPGTLLLDEVVAAGSTRQHLdqLQYNQQFL----- 277
Cdd:PLN02574 145 T-----------------SPENV--EKLSPLGVP----VIGV----PENYDFDSKRIEFPKFYEL--IKEDFDFVpkpvi 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 278 SCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGE-RLKLHEKTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLIL 356
Cdd:PLN02574 196 KQDDVAAIMYSSGTTGASKGVVLTHRNLIAMVELFVRfEASQYEYPGSDNVYLAALPMFHIYGLSLFVVGLLSLGSTIVV 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 357 ASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPdfssydiSTMCGGVI--------AGSPAPPELIRAIINKINMKD 428
Cdd:PLN02574 276 MRR-FDASDMVKVIDRFKVTHFPVVPPILMALTKKA-------KGVCGEVLkslkqvscGAAPLSGKFIQDFVQTLPHVD 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 429 LVVAYGTTENSPVTFAHFPEDTVeQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAV 508
Cdd:PLN02574 348 FIQGYGMTESTAVGTRGFNTEKL-SKYSSVGLLAPNMQAKVVDWSTGCLLPPGNCGELWIQGPGVMKGYLNNPKATQSTI 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 509 DQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEE 588
Cdd:PLN02574 427 DKDGWLRTGDIAYFDEDGYLYIVDRLKEIIKYKGFQIAPADLEAVLISHPEIIDAAVTAVPDKECGEIPVAFVVRRQGST 506
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 572872742 589 TTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIqkfkLREQMERHL 638
Cdd:PLN02574 507 LSQEAVINYVAKQVAPYKKVRKVVFVQSIPKSPAGKI----LRRELKRSL 552
|
|
| A_NRPS_Bac |
cd17655 |
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ... |
101-632 |
1.10e-35 |
|
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341310 [Multi-domain] Cd Length: 490 Bit Score: 140.54 E-value: 1.10e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 101 QCLETTAQRVPEREALVVlhEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVN 180
Cdd:cd17655 1 ELFEEQAEKTPDHTAVVF--EDQTLTYRELNERANQLARTLREKGVGPDTIVGIMAERSLEMIVGILGILKAGGAYLPID 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 181 PAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNvlkqicPEVENAQPGALKSQRLPDLTTVISVDaplpgtllldevvaa 260
Cdd:cd17655 79 PDYPEERIQYILEDSGADILLTQSHLQPPIAFI------GLIDLLDEDTIYHEESENLEPVSKSD--------------- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 261 gstrqhldQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKtpeqLRMILPNPLYHCLgS 340
Cdd:cd17655 138 --------DLAY------------VIYTSGSTGKPKGVMIEHRGVVNLVEWANKVIYQGEH----LRVALFASISFDA-S 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 341 VAGTMMCLMYGATLILA--SPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMcggVIAGSPAPPELIR 418
Cdd:cd17655 193 VTEIFASLLSGNTLYIVrkETVLDGQALTQYIRQNRITIIDLTPAHLKLLDAADDSEGLSLKHL---IVGGEALSTELAK 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 419 AIINKINMK-DLVVAYGTTENSpVTFAHFPEDTVEQKAESV--GRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVML 495
Cdd:cd17655 270 KIIELFGTNpTITNAYGPTETT-VDASIYQYEPETDQQVSVpiGKPLGNTRIYILD-QYGRPQPVGVAGELYIGGEGVAR 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 496 GYWGEPQKTEEA------VDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGgeniYPAELEDFFH---THPKVQEVQV 565
Cdd:cd17655 348 GYLNRPELTAEKfvddpfVPGERMYRTGDLARWLPDGNIEFLGRIDHQVkIRG----YRIELGEIEArllQHPDIKEAVV 423
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 572872742 566 VGVKDDRMGEEICACIRLKdgEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:cd17655 424 IARKDEQGQNYLCAYIVSE--KELPVAQLREFLARELPDYMIPSYFIKLDEIPLTPNGKVDRKALPE 488
|
|
| ACSBG_like |
cd05933 |
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very ... |
125-633 |
4.57e-34 |
|
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very long-chain fatty acid CoA synthetase is named bubblegum because Drosophila melanogaster mutant bubblegum (BGM) has elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene of this family. The human homolog (hsBG) has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. VL-FACS is involved in the first reaction step of very long chain fatty acid degradation. It catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341256 [Multi-domain] Cd Length: 596 Bit Score: 137.49 E-value: 4.57e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 125 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKvgCKAlvfpk 204
Cdd:cd05933 9 LTYKEYYEACRQAAKAFLKLGLERFHGVGILGFNSPEWFIAAVGAIFAGGIAVGIYTTNSPEACQYVAET--SEA----- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 205 qfktqqyynvlkQICPeVENAQPGALKSQ---RLPDLTTVISVDAPL----PGTLLLDEVVAAG--STRQHLDQLQYNQQ 275
Cdd:cd05933 82 ------------NILV-VENQKQLQKILQiqdKLPHLKAIIQYKEPLkekePNLYSWDEFMELGrsIPDEQLDAIISSQK 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 276 FLSCHDPIniqFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMILPNPLYHclgsVAGTMM----CLMYG 351
Cdd:cd05933 149 PNQCCTLI---YTSGTTGMPKGVMLSHDNITWTAKAASQHMDLRPATVGQESVVSYLPLSH----IAAQILdiwlPIKVG 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 352 ATLILASPIfNGKKALEAISRE-RGTFLYGTPTMFVDIL----------------------------NQPDFSSYDISTM 402
Cdd:cd05933 222 GQVYFAQPD-ALKGTLVKTLREvRPTAFMGVPRVWEKIQekmkavgaksgtlkrkiaswakgvgletNLKLMGGESPSPL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 403 CGGVI----------------------AGSPAPPELIRAIINkINMKdLVVAYGTTENSPvtfAHFPEDTVEQKAESVGR 460
Cdd:cd05933 301 FYRLAkklvfkkvrkalgldrcqkfftGAAPISRETLEFFLS-LNIP-IMELYGMSETSG---PHTISNPQAYRLLSCGK 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 461 IMPHTEARIMNMEAgtlaklNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIR 540
Cdd:cd05933 376 ALPGCKTKIHNPDA------DGIGEICFWGRHVFMGYLNMEDKTEEAIDEDGWLHSGDLGKLDEDGFLYITGRIKELIIT 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 541 -GGENIYPAELEDFFHTH-PKVQEVQVVGVK---------------------DDRMGEEICACIRLKDGEETTVEEIKAF 597
Cdd:cd05933 450 aGGENVPPVPIEDAVKKElPIISNAMLIGDKrkflsmlltlkcevnpetgepLDELTEEAIEFCRKLGSQATRVSEIAGG 529
|
570 580 590
....*....|....*....|....*....|....*.
gi 572872742 598 CKGKISHFkIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:cd05933 530 KDPKVYEA-IEEGIKRVNKKAISNAQKIQKWVILEK 564
|
|
| PRK13383 |
PRK13383 |
acyl-CoA synthetase; Provisional |
77-634 |
1.17e-33 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 139531 [Multi-domain] Cd Length: 516 Bit Score: 135.12 E-value: 1.17e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 77 STPIGGLSYVQGCTKKHLNSKTVgqcLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWG 156
Cdd:PRK13383 18 PSPRAVLRLLREASRGGTNPYTL---LAVTAARWPGRTAII--DDDGALSYRELQRATESLARRLTRDGVAPGRAVGVMC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 157 PNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFPKQFKTQqyYNVLKQICPEVENAQPGALKSQRLP 236
Cdd:PRK13383 93 RNGRGFVTAVFAVGLLGADVVPISTEFRSDALAAALRAHHISTVVADNEFAER--IAGADDAVAVIDPATAGAEESGGRP 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 237 DLttvisvdAPlPGTLLLdevvaagstrqhldqlqynqqflschdpiniqFTSGTTGSPKGATLSHY--NIVNNSNILGE 314
Cdd:PRK13383 171 AV-------AA-PGRIVL--------------------------------LTSGTTGKPKGVPRAPQlrSAVGVWVTILD 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 315 RLKLHEKTpeqlRMILPNPLYHCLGsVAGTMMCLMYGATlILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDF 394
Cdd:PRK13383 211 RTRLRTGS----RISVAMPMFHGLG-LGMLMLTIALGGT-VLTHRHFDAEAALAQASLHRADAFTAVPVVLARILELPPR 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 395 SSYDISTMCGGVI--AGSPAPPELIRAIINKINmKDLVVAYGTTENSPVTFAHfPEDtVEQKAESVGRIMPHTEARIMNM 472
Cdd:PRK13383 285 VRARNPLPQLRVVmsSGDRLDPTLGQRFMDTYG-DILYNGYGSTEVGIGALAT-PAD-LRDAPETVGKPVAGCPVRILDR 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 473 EAGTLAKLNTpGELCIRGYCVMLGYWGEPQKteeAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELED 552
Cdd:PRK13383 362 NNRPVGPRVT-GRIFVGGELAGTRYTDGGGK---AV-VDGMTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPRAVEN 436
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 553 FFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIqkfkLRE 632
Cdd:PRK13383 437 ALAAHPAVADNAVIGVPDERFGHRLAAFVVLHPGSGVDAAQLRDYLKDRVSRFEQPRDINIVSSIPRNPTGKV----LRK 512
|
..
gi 572872742 633 QM 634
Cdd:PRK13383 513 EL 514
|
|
| ACS-like |
cd17634 |
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ... |
98-625 |
2.53e-32 |
|
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.
Pssm-ID: 341289 [Multi-domain] Cd Length: 587 Bit Score: 131.93 E-value: 2.53e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 98 TVGQCLETTAQRVPEREALVVLHED---VR-LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAG 173
Cdd:cd17634 54 LAANALDRHLRENGDRTAIIYEGDDtsqSRtISYRELHREVCRFAGTLLDLGVKKGDRVAIYMPMIPEAAVAMLACARIG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 174 IILVSVNPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVENAQpgalksqrLPDLTTVISVD---APLPG 250
Cdd:cd17634 134 AVHSVIFGGFAPEAVAGRIIDSSSRLLITADGGVRAGRSVPLKKNVDDALNPN--------VTSVEHVIVLKrtgSDIDW 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 251 T----LLLDEVVAAGSTRqhldqlqYNQQFLSCHDPINIQFTSGTTGSPKGATLSHynivnnsnilGERLKLHEKTPEQL 326
Cdd:cd17634 206 QegrdLWWRDLIAKASPE-------HQPEAMNAEDPLFILYTSGTTGKPKGVLHTT----------GGYLVYAATTMKYV 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 327 RMILPNPLYHCLGSVaGTMMC---LMYGATLILA-SPIFNGK-------KALEAISRERGTFLYGTPTMFVDILNQPD-- 393
Cdd:cd17634 269 FDYGPGDIYWCTADV-GWVTGhsyLLYGPLACGAtTLLYEGVpnwptpaRMWQVVDKHGVNILYTAPTAIRALMAAGDda 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 394 FSSYDISTMCGGVIAGSPAPPELIRAIINKINMKD--LVVAYGTTENSPVTFAHFPeDTVEQKAESVGRIMPHTEARIMN 471
Cdd:cd17634 348 IEGTDRSSLRILGSVGEPINPEAYEWYWKKIGKEKcpVVDTWWQTETGGFMITPLP-GAIELKAGSATRPVFGVQPAVVD 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 472 MEaGTLAKLNTPGELCIRGYC--VMLGYWGEPQKTEEAVDQ--DKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYP 547
Cdd:cd17634 427 NE-GHPQPGGTEGNLVITDPWpgQTRTLFGDHERFEQTYFStfKGMYFSGDGARRDEDGYYWITGRSDDVINVAGHRLGT 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 548 AELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEE---TTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGK 624
Cdd:cd17634 506 AEIESVLVAHPKVAEAAVVGIPHAIKGQAPYAYVVLNHGVEpspELYAELRNWVRKEIGPLATPDVVHWVDSLPKTRSGK 585
|
.
gi 572872742 625 I 625
Cdd:cd17634 586 I 586
|
|
| PRK05620 |
PRK05620 |
long-chain fatty-acid--CoA ligase; |
191-636 |
3.74e-32 |
|
long-chain fatty-acid--CoA ligase;
Pssm-ID: 180167 [Multi-domain] Cd Length: 576 Bit Score: 131.44 E-value: 3.74e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 191 VLKKVGCKALVF-P--KQFKTQQYYNVLKQICPEVENAQPgALKSQRLPDLTTVISVDAPL-PGTLLLDEvvAAGSTRQH 266
Cdd:PRK05620 80 VLFAVACMGAVFnPlnKQLMNDQIVHIINHAEDEVIVADP-RLAEQLGEILKECPCVRAVVfIGPSDADS--AAAHMPEG 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 267 LDQLQYNQQF-----------LSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNIL--GERLKLHEKTPeqlrMILPNP 333
Cdd:PRK05620 157 IKVYSYEALLdgrstvydwpeLDETTAAAICYSTGTTGAPKGVVYSHRSLYLQSLSLrtTDSLAVTHGES----FLCCVP 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 334 LYHCLgSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDIL-----NQPDFSSydISTMCGGvia 408
Cdd:PRK05620 233 IYHVL-SWGVPLAAFMSGTPLVFPGPDLSAPTLAKIIATAMPRVAHGVPTLWIQLMvhylkNPPERMS--LQEIYVG--- 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 409 GSPAPPELIRAIINKINMkDLVVAYGTTENSPV-TFAHFPE----DTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTP 483
Cdd:PRK05620 307 GSAVPPILIKAWEERYGV-DVVHVWGMTETSPVgTVARPPSgvsgEARWAYRVSQGRFPASLEYRIVNDGQVMESTDRNE 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 484 GELCIRGYCVMLGYWGEPQKTE---------EAVD-------QDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYP 547
Cdd:PRK05620 386 GEIQVRGNWVTASYYHSPTEEGggaastfrgEDVEdandrftADGWLRTGDVGSVTRDGFLTIHDRARDVIRSGGEWIYS 465
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 548 AELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEE---TTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGK 624
Cdd:PRK05620 466 AQLENYIMAAPEVVECAVIGYPDDKWGERPLAVTVLAPGIEptrETAERLRDQLRDRLPNWMLPEYWTFVDEIDKTSVGK 545
|
490
....*....|..
gi 572872742 625 IQKFKLREQMER 636
Cdd:PRK05620 546 FDKKDLRQHLAD 557
|
|
| A_NRPS_GliP_like |
cd17653 |
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ... |
101-632 |
4.20e-32 |
|
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of nonribosomal peptide synthases (NRPS) gliotoxin biosynthesis protein P (GliP), thioclapurine biosynthesis protein P (tcpP) and Sirodesmin biosynthesis protein P (SirP). In the filamentous fungus Aspergillus fumigatus, NRPS GliP is involved in the biosynthesis of gliotoxin, which is initiated by the condensation of serine and phenylalanine. Studies show that GliP is not required for invasive aspergillosis, suggesting that the principal targets of gliotoxin are neutrophils or other phagocytes. SirP is a phytotoxin produced by the fungus Leptosphaeria maculans, which causes blackleg disease of canola (Brassica napus). In the fungus Claviceps purpurea, NRPS tcpP catalyzes condensation of tyrosine and glycine, part of biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) that lacks the reactive thiol group for toxicity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341308 [Multi-domain] Cd Length: 433 Bit Score: 129.35 E-value: 4.20e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 101 QCLETTAQRVPEreALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVN 180
Cdd:cd17653 1 DAFERIAAAHPD--AVAVESLGGSLTYGELDAASNALANRLLQLGVVPGDVVPLLSDRSLEMLVAILAILKAGAAYVPLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 181 PAYQAMELEYVLKKVGCKALVFPKqfktqqyynvlkqicpevenaqpgalksqrlpdlttvisvdaplpgtllldevvaa 260
Cdd:cd17653 79 AKLPSARIQAILRTSGATLLLTTD-------------------------------------------------------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 261 gstrqhldqlqynqqflSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQLRMILPNPLYH-CLG 339
Cdd:cd17653 103 -----------------SPDDLAYIIFTSGSTGIPKGVMVPHRGVLNYVSQPPARLDV---GPGSRVAQVLSIAFDaCIG 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 340 SVAGTmmcLMYGATLILASPIFNgkkaLEAISRERgTFLYGTPTmFVDILNQPDFSSYDIStmcggVIAGSPAPPELI-- 417
Cdd:cd17653 163 EIFST---LCNGGTLVLADPSDP----FAHVARTV-DALMSTPS-ILSTLSPQDFPNLKTI-----FLGGEAVPPSLLdr 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 418 ----RAIINkinmkdlvvAYGTTENS-PVTFAHF-PEDTVeqkaeSVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGY 491
Cdd:cd17653 229 wspgRRLYN---------AYGPTECTiSSTMTELlPGQPV-----TIGKPIPNSTCYILD-ADLQPVPEGVVGEICISGV 293
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 492 CVMLGYWGEPQKTEEAVDQDKW------YWTGDVATMNEQGFCKIVGRSKDMI-IRG-----GENIYPAELEDffhthPK 559
Cdd:cd17653 294 QVARGYLGNPALTASKFVPDPFwpgsrmYRTGDYGRWTEDGGLEFLGREDNQVkVRGfrinlEEIEEVVLQSQ-----PE 368
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 572872742 560 VQEVQVVGVKDdrmgeEICACIRlkdGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 632
Cdd:cd17653 369 VTQAAAIVVNG-----RLVAFVT---PETVDVDGLRSELAKHLPSYAVPDRIIALDSFPLTANGKVDRKALRE 433
|
|
| LC-FACS_euk |
cd05927 |
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ... |
125-567 |
1.02e-31 |
|
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are eukaryotic fatty acid CoA synthetases that activate fatty acids with chain lengths of 12 to 20. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells.
Pssm-ID: 341250 [Multi-domain] Cd Length: 545 Bit Score: 129.64 E-value: 1.02e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 125 LTFAQLKEEVDKAASGLLSIGLC--KGDRLGMWGPNSYAWVLMQLATAQAGIILVsvnPAYQAM---ELEYVLKKVGCKA 199
Cdd:cd05927 6 ISYKEVAERADNIGSALRSLGGKpaPASFVGIYSINRPEWIISELACYAYSLVTV---PLYDTLgpeAIEYILNHAEISI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 200 LVFPKQFKTQQYYNVLKQICPEVENAQPGAlksqrlPDLTTVISvdaplpgtllldevvaagstrqhldqlqynqqflsc 279
Cdd:cd05927 83 VFCDAGVKVYSLEEFEKLGKKNKVPPPPPK------PEDLATIC------------------------------------ 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 280 hdpiniqFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMILPNPLYHCLGSVAgTMMCLMYGA------- 352
Cdd:cd05927 121 -------YTSGTTGNPKGVMLTHGNIVSNVAGVFKILEILNKINPTDVYISYLPLAHIFERVV-EALFLYHGAkigfysg 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 353 --------------TLILASP---------IFNG-------KKAL--EAISRERGTFLYG--TPTMFVD--ILNQpdfss 396
Cdd:cd05927 193 dirlllddikalkpTVFPGVPrvlnriydkIFNKvqakgplKRKLfnFALNYKLAELRSGvvRASPFWDklVFNK----- 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 397 ydISTMCGG----VIAGS-PAPPELI---RAIinkinMKDLVV-AYGTTENSPVTFAHFPEDTVeqkAESVGRIMPHTEA 467
Cdd:cd05927 268 --IKQALGGnvrlMLTGSaPLSPEVLeflRVA-----LGCPVLeGYGQTECTAGATLTLPGDTS---VGHVGGPLPCAEV 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 468 RIMNM-EAGTLAKLNTP-GELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGEN 544
Cdd:cd05927 338 KLVDVpEMNYDAKDPNPrGEVCIRGPNVFSGYYKDPEKTAEALDEDGWLHTGDIGEWLPNGTLKIIDRKKNIFkLSQGEY 417
|
490 500
....*....|....*....|...
gi 572872742 545 IYPAELEDFFHTHPKVQEVQVVG 567
Cdd:cd05927 418 VAPEKIENIYARSPFVAQIFVYG 440
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
89-627 |
5.74e-31 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 130.28 E-value: 5.74e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 89 CTKKHLNSKTVGQCLETTAQRVPEREALVVlhEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLA 168
Cdd:PRK12467 504 APATEYAPDCVHQLIEAQARQHPERPALVF--GEQVLSYAELNRQANRLAHVLIAAGVGPDVLVGIAVERSIEMVVGLLA 581
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 169 TAQAGIILVSVNPAYQAMELEYVLKKVGCKALVfpkqfktqqyynvlkqicpevenAQPGALKSQRLPDLTTVISVDAPL 248
Cdd:PRK12467 582 VLKAGGAYVPLDPEYPQDRLAYMLDDSGVRLLL-----------------------TQSHLLAQLPVPAGLRSLCLDEPA 638
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 249 PgtLLLDEVVAAGSTRQHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQlRM 328
Cdd:PRK12467 639 D--LLCGYSGHNPEVALDPDNLAY------------VIYTSGSTGQPKGVAISHGALANYVCVIAERLQL---AADD-SM 700
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 329 ILPNPLYHCLGsvaGTMM--CLMYGATLILASP--IFNGKKALEAISRERGTFLYGTPTMFVDILN--QPDFSSYDISTM 402
Cdd:PRK12467 701 LMVSTFAFDLG---VTELfgALASGATLHLLPPdcARDAEAFAALMADQGVTVLKIVPSHLQALLQasRVALPRPQRALV 777
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 403 CGGVIagspAPPELIRAIINKINMKDLVVAYGTTENSpVTFAHFP--EDTVEQKAESVGRIMPHTEARIMNMEAGTLAkL 480
Cdd:PRK12467 778 CGGEA----LQVDLLARVRALGPGARLINHYGPTETT-VGVSTYElsDEERDFGNVPIGQPLANLGLYILDHYLNPVP-V 851
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 481 NTPGELCIRGYCVMLGYWGEPQKTEE-------AVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRgGENIYPAELED 552
Cdd:PRK12467 852 GVVGELYIGGAGLARGYHRRPALTAErfvpdpfGADGGRLYRTGDLARYRADGVIEYLGRMDHQVkIR-GFRIELGEIEA 930
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 572872742 553 FFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEET----TVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 627
Cdd:PRK12467 931 RLLAQPGVREAVVLAQPGDAGLQLVAYLVPAAVADGAehqaTRDELKAQLRQVLPDYMVPAHLLLLDSLPLTPNGKLDR 1009
|
|
| A_NRPS_TubE_like |
cd05906 |
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) ... |
120-636 |
6.10e-31 |
|
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPSs that synthesize toxins and antitumor agents; for example, TubE for Tubulysine, CrpA for cryptophycin, TdiA for terrequinone A, KtzG for kutzneride, and Vlm1/Vlm2 for Valinomycin. Nonribosomal peptide synthetases are large multifunctional enzymes which synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341232 [Multi-domain] Cd Length: 540 Bit Score: 127.40 E-value: 6.10e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 120 HEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRlgmwgpnsyawVLMQLATAQ-----------AGII--LVSVNPAYQam 186
Cdd:cd05906 35 GSEEFQSYQDLLEDARRLAAGLRQLGLRPGDS-----------VILQFDDNEdfipafwacvlAGFVpaPLTVPPTYD-- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 187 ELEYVLKKVgckalvfpkqfktqqyYNVLKQIcpevenAQPGALKSQRL-PDLTTvISVDAPLPGtlllDEVVAAGSTRQ 265
Cdd:cd05906 102 EPNARLRKL----------------RHIWQLL------GSPVVLTDAELvAEFAG-LETLSGLPG----IRVLSIEELLD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 266 HLDQLQYNQQflSCHDPINIQFTSGTTGSPKGATLSHYNIVNnsnilgeRLK----LHEKTPEQLRMilpN--PLYHCLG 339
Cdd:cd05906 155 TAADHDLPQS--RPDDLALLMLTSGSTGFPKAVPLTHRNILA-------RSAgkiqHNGLTPQDVFL---NwvPLDHVGG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 340 SVAGTMMCLMYG-------ATLILASPIfngkKALEAISRERGT------FLYgtpTMFVDILNQPDFSSYDISTMCGGV 406
Cdd:cd05906 223 LVELHLRAVYLGcqqvhvpTEEILADPL----RWLDLIDRYRVTitwapnFAF---ALLNDLLEEIEDGTWDLSSLRYLV 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 407 IAGSPAPPELIRAIIN-----KINMKDLVVAYGTTEN-SPVTFAH-FPEDTVEQKAE--SVGRIMPHTEARIMNmEAGTL 477
Cdd:cd05906 296 NAGEAVVAKTIRRLLRllepyGLPPDAIRPAFGMTETcSGVIYSRsFPTYDHSQALEfvSLGRPIPGVSMRIVD-DEGQL 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 478 AKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEqGFCKIVGRSKDMIIRGGENIYPAELEDFfhth 557
Cdd:cd05906 375 LPEGEVGRLQVRGPVVTKGYYNNPEANAEAFTEDGWFRTGDLGFLDN-GNLTITGRTKDTIIVNGVNYYSHEIEAA---- 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 558 pkVQEVQVV--------GVKDDRMGEEICAC-----IRLKDGEETTVEEIkafcKGKISH-FKI-PKYIVFV--TNYPLT 620
Cdd:cd05906 450 --VEEVPGVepsftaafAVRDPGAETEELAIffvpeYDLQDALSETLRAI----RSVVSReVGVsPAYLIPLpkEEIPKT 523
|
570
....*....|....*.
gi 572872742 621 ISGKIQKFKLREQMER 636
Cdd:cd05906 524 SLGKIQRSKLKAAFEA 539
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
278-625 |
9.88e-31 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 128.93 E-value: 9.88e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 278 SCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHektPEQlrmILPN--PLYHCLGSVAGTMMCLMYGATLI 355
Cdd:PRK06814 791 DPDDPAVILFTSGSEGTPKGVVLSHRNLLANRAQVAARIDFS---PED---KVFNalPVFHSFGLTGGLVLPLLSGVKVF 864
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 356 L-ASPIfNGKKALEAISRERGTFLYGTPTMfvdiLN------QP-DFSS--YdistmcggVIAGSpappELIRAIINKIN 425
Cdd:PRK06814 865 LyPSPL-HYRIIPELIYDTNATILFGTDTF----LNgyaryaHPyDFRSlrY--------VFAGA----EKVKEETRQTW 927
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 426 MKDLVV----AYGTTENSPV----TFAHFpedtveqKAESVGRIMPHTEARIMNMEAgtlakLNTPGELCIRGYCVMLGY 497
Cdd:PRK06814 928 MEKFGIrileGYGVTETAPVialnTPMHN-------KAGTVGRLLPGIEYRLEPVPG-----IDEGGRLFVRGPNVMLGY 995
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 498 WGE--PQKTEEAVDqdKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHT-HPKVQEVqVVGVKDDRMG 574
Cdd:PRK06814 996 LRAenPGVLEPPAD--GWYDTGDIVTIDEEGFITIKGRAKRFAKIAGEMISLAAVEELAAElWPDALHA-AVSIPDARKG 1072
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 572872742 575 EEIcacIRLKDGEETTVEEIKAFCKGK-ISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:PRK06814 1073 ERI---ILLTTASDATRAAFLAHAKAAgASELMVPAEIITIDEIPLLGTGKI 1121
|
|
| MACS_like_2 |
cd05973 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
281-631 |
1.07e-30 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341277 [Multi-domain] Cd Length: 437 Bit Score: 125.32 E-value: 1.07e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 281 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQLRMILPNP-----LYHclgSVAGTMmcLMYGATLI 355
Cdd:cd05973 89 DPFVMMFTSGTTGLPKGVPVPLRALAAFGAYLRDAVDL---RPEDSFWNAADPgwaygLYY---AITGPL--ALGHPTIL 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 356 LASPiFNGKKALEAISRERGTFLYGTPTMFVDILNqpdfSSYDISTMCGGVI-----AGSPAPPELIRAIINKIN--MKD 428
Cdd:cd05973 161 LEGG-FSVESTWRVIERLGVTNLAGSPTAYRLLMA----AGAEVPARPKGRLrrvssAGEPLTPEVIRWFDAALGvpIHD 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 429 lvvAYGTTE-NSPVTFAHFPEDTVeqKAESVGRIMPHTEARIMNMEAGTLAKlNTPGELCIRGYCVML----GYWGEPQK 503
Cdd:cd05973 236 ---HYGQTElGMVLANHHALEHPV--HAGSAGRAMPGWRVAVLDDDGDELGP-GEPGRLAIDIANSPLmwfrGYQLPDTP 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 504 TEEAvdqdKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRL 583
Cdd:cd05973 310 AIDG----GYYLTGDTVEFDPDGSFSFIGRADDVITMSGYRIGPFDVESALIEHPAVAEAAVIGVPDPERTEVVKAFVVL 385
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 572872742 584 KDGEETTVE---EIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05973 386 RGGHEGTPAladELQLHVKKRLSAHAYPRTIHFVDELPKTPSGKIQRFLLR 436
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
99-627 |
1.08e-30 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 129.31 E-value: 1.08e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 99 VGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVS 178
Cdd:PRK12316 513 VHRLFEEQVERTPEAPALA--FGEETLDYAELNRRANRLAHALIERGVGPDVLVGVAMERSIEMVVALLAILKAGGAYVP 590
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 179 VNPAYQAMELEYVLKKVGCKALVfpkqfkTQQYynvLKQICPevenaqpgalksqrLPDLTTVISVDAplPGTLLLDEVV 258
Cdd:PRK12316 591 LDPEYPAERLAYMLEDSGVQLLL------SQSH---LGRKLP--------------LAAGVQVLDLDR--PAAWLEGYSE 645
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 259 AAGSTRQHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhektPEQLRMILPNPLYHCL 338
Cdd:PRK12316 646 ENPGTELNPENLAY------------VIYTSGSTGKPKGAGNRHRALSNRLCWMQQAYGL----GVGDTVLQKTPFSFDV 709
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 339 gSVAGTMMCLMYGATLILASP--IFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCggVIAGSPAPPEL 416
Cdd:PRK12316 710 -SVWEFFWPLMSGARLVVAAPgdHRDPAKLVELINREGVDTLHFVPSMLQAFLQDEDVASCTSLRRI--VCSGEALPADA 786
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 417 IRAIINKINMKDLVVAYGTTENSpVTFAHFPedTVEQKAESV--GRIMPHTEARIMNMEAGTLAkLNTPGELCIRGYCVM 494
Cdd:PRK12316 787 QEQVFAKLPQAGLYNLYGPTEAA-IDVTHWT--CVEEGGDSVpiGRPIANLACYILDANLEPVP-VGVLGELYLAGRGLA 862
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 495 LGYWGEPQKTEEA------VDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGV 568
Cdd:PRK12316 863 RGYHGRPGLTAERfvpspfVAGERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAAVLAV 942
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 572872742 569 KddrmGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 627
Cdd:PRK12316 943 D----GKQLVGYVVLESEGGDWREALKAHLAASLPEYMVPAQWLALERLPLTPNGKLDR 997
|
|
| AACS_like |
cd05968 |
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ... |
81-631 |
1.10e-30 |
|
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This uncharacterized acyl-CoA synthetase family (EC 6.2.1.16, or acetoacetate#CoA ligase or acetoacetate:CoA ligase (AMP-forming)) is highly homologous to acetoacetyl-CoA synthetase. However, the proteins in this family exist in only bacteria and archaea. AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms.
Pssm-ID: 341272 [Multi-domain] Cd Length: 610 Bit Score: 127.22 E-value: 1.10e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 81 GGLSYVQGCTKKHLNskTVGQCLETTAQRVPEREALVVLHED--VR-LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGP 157
Cdd:cd05968 47 GGKPWAAWFVGGRMN--IVEQLLDKWLADTRTRPALRWEGEDgtSRtLTYGELLYEVKRLANGLRALGVGKGDRVGIYLP 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 158 NSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALvfpkqFKTQQYYNVLKQICPEvENAQPGALKSQRLPD 237
Cdd:cd05968 125 MIPEIVPAFLAVARIGGIVVPIFSGFGKEAAATRLQDAEAKAL-----ITADGFTRRGREVNLK-EEADKACAQCPTVEK 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 238 LTTVISVDAPLPGT----LLLDEVVAA---GSTRQHLDqlqynqqflschDPINIQFTSGTTGSPKGATLSHynivnnsn 310
Cdd:cd05968 199 VVVVRHLGNDFTPAkgrdLSYDEEKETagdGAERTESE------------DPLMIIYTSGTTGKPKGTVHVH-------- 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 311 iLGERLKLHEKtpeqlrmilpnpLYHCLG----------SVAGTMM-------CLMYGATLIL--ASPIFNGKKAL-EAI 370
Cdd:cd05968 259 -AGFPLKAAQD------------MYFQFDlkpgdlltwfTDLGWMMgpwlifgGLILGATMVLydGAPDHPKADRLwRMV 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 371 SRERGTFLYGTPTMF-------VDILNQPDFSSYDI--STmcggviaGSPAPPELIRAIINKINMKDL-VVAY-GTTENS 439
Cdd:cd05968 326 EDHEITHLGLSPTLIralkprgDAPVNAHDLSSLRVlgST-------GEPWNPEPWNWLFETVGKGRNpIINYsGGTEIS 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 440 PVTFAHFPEDTVeqKAESVGRIMPHTEARIMNmEAGTLAKlNTPGELCIRGYCVML--GYWGEPQKTEEAvdqdkwYWT- 516
Cdd:cd05968 399 GGILGNVLIKPI--KPSSFNGPVPGMKADVLD-ESGKPAR-PEVGELVLLAPWPGMtrGFWRDEDRYLET------YWSr 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 517 -------GDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEET 589
Cdd:cd05968 469 fdnvwvhGDFAYYDEEGYFYILGRSDDTINVAGKRVGPAEIESVLNAHPAVLESAAIGVPHPVKGEAIVCFVVLKPGVTP 548
|
570 580 590 600
....*....|....*....|....*....|....*....|....*
gi 572872742 590 T---VEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05968 549 TealAEELMERVADELGKPLSPERILFVKDLPKTRNAKVMRRVIR 593
|
|
| A_NRPS_PvdJ-like |
cd17649 |
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ... |
111-631 |
3.93e-30 |
|
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes pyoverdine biosynthesis protein PvdJ involved in the synthesis of pyoverdine, which consists of a chromophore group attached to a variable peptide chain and comprises around 6-12 amino acids that are specific for each Pseudomonas species, and for which the peptide might be first synthesized before the chromophore assembly. Also included is ornibactin biosynthesis protein OrbI; ornibactin is a tetrapeptide siderophore with an l-ornithine-d-hydroxyaspartate-l-serine-l-ornithine backbone. The adenylation domain at the N-terminal of OrbI possibly initiates the ornibactin with the binding of N5-hydroxyornithine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341304 [Multi-domain] Cd Length: 450 Bit Score: 123.63 E-value: 3.93e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 111 PEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEY 190
Cdd:cd17649 1 PDAVALV--FGDQSLSYAELDARANRLAHRLRALGVGPEVRVGIALERSLEMVVALLAILKAGGAYVPLDPEYPAERLRY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 191 VLKKVGckalvfpkqfktqqyynvlkqicpevenaqpgalksqrlpdLTTVISvdaplpgtllldevvaagstrQHLDQL 270
Cdd:cd17649 79 MLEDSG-----------------------------------------AGLLLT---------------------HHPRQL 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 271 QYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHektPEQlrMILPNPLYHCLGSVAGTMMCLMY 350
Cdd:cd17649 97 AY------------VIYTSGSTGTPKGVAVSHGPLAAHCQATAERYGLT---PGD--RELQFASFNFDGAHEQLLPPLIC 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 351 GATLILAS-PIFNGKKAL-EAISRERGTFLYGTPT---MFVDILNQPDFSSYDISTMCggVIAGSPAPPELIRAIINKin 425
Cdd:cd17649 160 GACVVLRPdELWASADELaEMVRELGVTVLDLPPAylqQLAEEADRTGDGRPPSLRLY--IFGGEALSPELLRRWLKA-- 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 426 MKDLVVAYGTTENSPVTFAHFPEDTVEQKAESV--GRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQK 503
Cdd:cd17649 236 PVRLFNAYGPTEATVTPLVWKCEAGAARAGASMpiGRPLGGRSAYILD-ADLNPVPVGVTGELYIGGEGLARGYLGRPEL 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 504 TEEAVDQD-------KWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVkDDRMGEE 576
Cdd:cd17649 315 TAERFVPDpfgapgsRLYRTGDLARWRDDGVIEYLGRVDHQVKIRGFRIELGEIEAALLEHPGVREAAVVAL-DGAGGKQ 393
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 572872742 577 ICACIRLKDGEET--TVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd17649 394 LVAYVVLRAAAAQpeLRAQLRTALRASLPDYMVPAHLVFLARLPLTPNGKLDRKALP 450
|
|
| PRK13388 |
PRK13388 |
acyl-CoA synthetase; Provisional |
104-633 |
7.57e-30 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237374 [Multi-domain] Cd Length: 540 Bit Score: 123.98 E-value: 7.57e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 104 ETTAQRVPER---EALVVLHEDVRLTFAQLKEEvdKAASGLLSIGLCKGDR---LGMWGPNSYAWVLMQLATAQAGIILV 177
Cdd:PRK13388 3 DTIAQLLRDRagdDTIAVRYGDRTWTWREVLAE--AAARAAALIALADPDRplhVGVLLGNTPEMLFWLAAAALGGYVLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 178 SVNPAYQAMELEYVLKKVGCKALVfpkqfktqqyynvlkqicpeVENAQPGALKSQRLPDLTtVISVDAPLpgtlLLDEV 257
Cdd:PRK13388 81 GLNTTRRGAALAADIRRADCQLLV--------------------TDAEHRPLLDGLDLPGVR-VLDVDTPA----YAELV 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 258 VAAGSTRQHLDqlqynqqfLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMilpnPLYHC 337
Cdd:PRK13388 136 AAAGALTPHRE--------VDAMDPFMLIFTSGTTGAPKAVRCSHGRLAFAGRALTERFGLTRDDVCYVSM----PLFHS 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 338 LGSVAGTMMCLMYGATLILaSPIFNGKKALEAISRERGTFL-Y-GTPTMFvdILNQPDFSSYDISTMCGGViaGSPAPPE 415
Cdd:PRK13388 204 NAVMAGWAPAVASGAAVAL-PAKFSASGFLDDVRRYGATYFnYvGKPLAY--ILATPERPDDADNPLRVAF--GNEASPR 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 416 LIRAIINKINMKdLVVAYGTTENSPVTFAH--FPEDTVEQKAESVGRIMPHTE---ARIMNMEAGTLAKLNTP-GELC-I 488
Cdd:PRK13388 279 DIAEFSRRFGCQ-VEDGYGSSEGAVIVVREpgTPPGSIGRGAPGVAIYNPETLtecAVARFDAHGALLNADEAiGELVnT 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 489 RGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGV 568
Cdd:PRK13388 358 AGAGFFEGYYNNPEATAERM-RHGMYWSGDLAYRDADGWIYFAGRTADWMRVDGENLSAAPIERILLRHPAINRVAVYAV 436
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 572872742 569 KDDRMGEEICACIRLKDGEETTVEEIKAFCKGK--ISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK13388 437 PDERVGDQVMAALVLRDGATFDPDAFAAFLAAQpdLGTKAWPRYVRIAADLPSTATNKVLKRELIAQ 503
|
|
| PRK07445 |
PRK07445 |
O-succinylbenzoic acid--CoA ligase; Reviewed |
407-640 |
1.64e-29 |
|
O-succinylbenzoic acid--CoA ligase; Reviewed
Pssm-ID: 236019 [Multi-domain] Cd Length: 452 Bit Score: 122.03 E-value: 1.64e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 407 IAGSPAPPEL-IRAIINKINmkdLVVAYGTTENSPVTFAHFPEDTVeQKAESVGRIMPHTEARIMNmeagtlaklNTPGE 485
Cdd:PRK07445 237 LGGAPAWPSLlEQARQLQLR---LAPTYGMTETASQIATLKPDDFL-AGNNSSGQVLPHAQITIPA---------NQTGN 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 486 LCIRGYCVMLGYWgePQKteeaVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQV 565
Cdd:PRK07445 304 ITIQAQSLALGYY--PQI----LDSQGIFETDDLGYLDAQGYLHILGRNSQKIITGGENVYPAEVEAAILATGLVQDVCV 377
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572872742 566 VGVKDDRMGEEICACIRLKDGeETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMERHLNL 640
Cdd:PRK07445 378 LGLPDPHWGEVVTAIYVPKDP-SISLEELKTAIKDQLSPFKQPKHWIPVPQLPRNPQGKINRQQLQQIAVQRLGL 451
|
|
| LC_FACS_bac |
cd05932 |
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ... |
123-567 |
7.91e-29 |
|
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase. Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase in this family is involved in the synthesis of isoprenoid wax ester storage compounds when grown on phytol as the sole carbon source. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341255 [Multi-domain] Cd Length: 508 Bit Score: 120.65 E-value: 7.91e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 123 VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALVF 202
Cdd:cd05932 5 VEFTWGEVADKARRLAAALRALGLEPGSKIALISKNCAEWFITDLAIWMAGHISVPLYPTLNPDTIRYVLEHSESKALFV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 203 PKqfktqqyynvlkqiCPEVENAQPGalksqrLPDltTVISVDAPLPGTLLLDEvvaagstrqHLDQLQYNQQFL---SC 279
Cdd:cd05932 85 GK--------------LDDWKAMAPG------VPE--GLISISLPPPSAANCQY---------QWDDLIAQHPPLeerPT 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 280 HDP---INIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKlhekTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLIL 356
Cdd:cd05932 134 RFPeqlATLIYTSGTTGQPKGVMLTFGSFAWAAQAGIEHIG----TEENDRMLSYLPLAHVTERVFVEGGSLYGGVLVAF 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 357 ASPIfngKKALEAISRERGTFLYGTPTMFVD----------------ILNQPDFSSYDISTMCGGV------IAGS---P 411
Cdd:cd05932 210 AESL---DTFVEDVQRARPTLFFSVPRLWTKfqqgvqdkipqqklnlLLKIPVVNSLVKRKVLKGLgldqcrLAGCgsaP 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 412 APPELIrAIINKINMkDLVVAYGTTENSPVTFAHFPEDtveQKAESVGRIMPHTEARImnmeagtlaklNTPGELCIRGY 491
Cdd:cd05932 287 VPPALL-EWYRSLGL-NILEAYGMTENFAYSHLNYPGR---DKIGTVGNAGPGVEVRI-----------SEDGEILVRSP 350
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 572872742 492 CVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGENIYPAELEDFFHTHPKVQEVQVVG 567
Cdd:cd05932 351 ALMMGYYKDPEATAEAFTADGFLRTGDKGELDADGNLTITGRVKDIFkTSKGKYVAPAPIENKLAEHDRVEMVCVIG 427
|
|
| A_NRPS_LgrA-like |
cd17645 |
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ... |
101-630 |
1.10e-28 |
|
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes linear gramicidin synthetase (LgrA) in Brevibacillus brevis. LgrA has a formylation domain fused to the N-terminal end that formylates its substrate for linear gramicidin synthesis to proceed. This formyl group is essential for the clinically important antibacterial activity of gramicidin by enabling head-to-head gramicidin dimers to make a beta-helical pore in gram-positive bacterial membranes, allowing free passage of monovalent cations, destroying the ion gradient and killing bacteria. This family also includes bacitracin synthetase 1 (known as ATP-dependent cysteine adenylase or BA1); it activates cysteine, incorporates two D-amino acids, releases and cyclizes the mature bacitracin, an antibiotic that is a mixture of related cyclic peptides that disrupt gram positive bacteria by interfering with cell wall and peptidoglycan synthesis. Also included is surfactin synthetase which activates and polymerizes the amino acids Leu, Glu, Asp, and Val to form the antibiotic surfactin.
Pssm-ID: 341300 [Multi-domain] Cd Length: 440 Bit Score: 119.20 E-value: 1.10e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 101 QCLETTAQRVPEREAlvVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVN 180
Cdd:cd17645 2 QLFEEQVERTPDHVA--VVDRGQSLTYKQLNEKANQLARHLRGKGVKPDDQVGIMLDKSLDMIAAILGVLKAGGAYVPID 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 181 PAYQAMELEYVLKKVGCKALVfpkqfktqqyynvlkqicpevenAQPGalksqrlpDLTTVIsvdaplpgtllldevvaa 260
Cdd:cd17645 80 PDYPGERIAYMLADSSAKILL-----------------------TNPD--------DLAYVI------------------ 110
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 261 gstrqhldqlqynqqflschdpiniqFTSGTTGSPKGATLSHYNIVNnsnILGERLKLHEKTPEQLRMILPNPLYHclGS 340
Cdd:cd17645 111 --------------------------YTSGSTGLPKGVMIEHHNLVN---LCEWHRPYFGVTPADKSLVYASFSFD--AS 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 341 VAGTMMCLMYGATL-ILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDIstmcggVIAGSPappelira 419
Cdd:cd17645 160 AWEIFPHLTAGAALhVVPSERRLDLDALNDYFNQEGITISFLPTGAAEQFMQLDNQSLRV------LLTGGD-------- 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 420 IINKINMK--DLVVAYGTTENSpVTFAHFPEDTVEQKAeSVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGY 497
Cdd:cd17645 226 KLKKIERKgyKLVNNYGPTENT-VVATSFEIDKPYANI-PIGKPIDNTRVYILD-EALQLQPIGVAGELCIAGEGLARGY 302
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 498 WGEPQKTEEA------VDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDD 571
Cdd:cd17645 303 LNRPELTAEKfivhpfVPGERMYRTGDLAKFLPDGNIEFLGRLDQQVKIRGYRIEPGEIEPFLMNHPLIELAAVLAKEDA 382
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 572872742 572 RMGEEICACIRLKdgEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 630
Cdd:cd17645 383 DGRKYLVAYVTAP--EEIPHEELREWLKNDLPDYMIPTYFVHLKALPLTANGKVDRKAL 439
|
|
| PRK07768 |
PRK07768 |
long-chain-fatty-acid--CoA ligase; Validated |
281-551 |
1.93e-28 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236091 [Multi-domain] Cd Length: 545 Bit Score: 120.10 E-value: 1.93e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 281 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILASPI 360
Cdd:PRK07768 153 DLALMQLTSGSTGSPKAVQITHGNLYANAEAMFVAAEF---DVETDVMVSWLPLFHDMGMVGFLTVPMYFGAELVKVTPM 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 361 -FNGKKAL--EAISRERGT------FLYgtpTMFVDIL-NQPDFSSYDISTMCGGVIAGSPAPPELIRAIIN-----KIN 425
Cdd:PRK07768 230 dFLRDPLLwaELISKYRGTmtaapnFAY---ALLARRLrRQAKPGAFDLSSLRFALNGAEPIDPADVEDLLDagarfGLR 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 426 MKDLVVAYGTTENS-PVTFAHFPE----DTV-------EQKAE-----------SVGRIMPHTEARIMNmEAGTLAKLNT 482
Cdd:PRK07768 307 PEAILPAYGMAEATlAVSFSPCGAglvvDEVdadllaaLRRAVpatkgntrrlaTLGPPLPGLEVRVVD-EDGQVLPPRG 385
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 572872742 483 PGELCIRGYCVMLGYWgEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELE 551
Cdd:PRK07768 386 VGVIELRGESVTPGYL-TMDGFIPAQDADGWLDTGDLGYLTEEGEVVVCGRVKDVIIMAGRNIYPTDIE 453
|
|
| ACS |
cd05966 |
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ... |
102-631 |
7.26e-28 |
|
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation.
Pssm-ID: 341270 [Multi-domain] Cd Length: 608 Bit Score: 118.82 E-value: 7.26e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 102 CLETTAQRVPEREALVVLHEDV----RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILV 177
Cdd:cd05966 58 CLDRHLKERGDKVAIIWEGDEPdqsrTITYRELLREVCRFANVLKSLGVKKGDRVAIYMPMIPELVIAMLACARIGAVHS 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 178 SVNPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEvenaqpgALKsqRLPDLTTVISV-----DAPL-PG- 250
Cdd:cd05966 138 VVFAGFSAESLADRINDAQCKLVITADGGYRGGKVIPLKEIVDE-------ALE--KCPSVEKVLVVkrtggEVPMtEGr 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 251 TLLLDEVVAagstrqhlDQLQYNQ-QFLSCHDPINIQFTSGTTGSPKG-----------ATLSHYNIVNnsnilgerlkl 318
Cdd:cd05966 209 DLWWHDLMA--------KQSPECEpEWMDSEDPLFILYTSGSTGKPKGvvhttggyllyAATTFKYVFD----------- 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 319 hektpeqlrmILPNPLYHC---LGSVAG-TMMC---LMYGATlilaSPIFNGKKAL-------EAISRERGTFLYGTPT- 383
Cdd:cd05966 270 ----------YHPDDIYWCtadIGWITGhSYIVygpLANGAT----TVMFEGTPTYpdpgrywDIVEKHKVTIFYTAPTa 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 384 --MFVDILNQPdFSSYDISTM--CGGViaGSPAPPELIRAIINKINMKDLVVA--YGTTENSPVTFAHFPEDTvEQKAES 457
Cdd:cd05966 336 irALMKFGDEW-VKKHDLSSLrvLGSV--GEPINPEAWMWYYEVIGKERCPIVdtWWQTETGGIMITPLPGAT-PLKPGS 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 458 VGRIMPHTEARIMNmEAGTLAKLNTPGELCIR----GycVMLGYWGEPQKTEEAVDQD--KWYWTGDVATMNEQGFCKIV 531
Cdd:cd05966 412 ATRPFFGIEPAILD-EEGNEVEGEVEGYLVIKrpwpG--MARTIYGDHERYEDTYFSKfpGYYFTGDGARRDEDGYYWIT 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 532 GRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVE---EIKAFCKGKISHFKIP 608
Cdd:cd05966 489 GRVDDVINVSGHRLGTAEVESALVAHPAVAEAAVVGRPHDIKGEAIYAFVTLKDGEEPSDElrkELRKHVRKEIGPIATP 568
|
570 580
....*....|....*....|...
gi 572872742 609 KYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05966 569 DKIQFVPGLPKTRSGKIMRRILR 591
|
|
| A_NRPS_TlmIV_like |
cd12114 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including ... |
114-625 |
1.69e-26 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety.
Pssm-ID: 341279 [Multi-domain] Cd Length: 477 Bit Score: 113.13 E-value: 1.69e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 114 EALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLK 193
Cdd:cd12114 2 DATAVICGDGTLTYGELAERARRVAGALKAAGVRPGDLVAVTLPKGPEQVVAVLGILAAGAAYVPVDIDQPAARREAILA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 194 KVGCKALVfpkqfktqqyynvlkqicpeveNAQPGALKSQRLPDLTTVISVDAPLPGTLLldevvaagSTRQHLDQLQYn 273
Cdd:cd12114 82 DAGARLVL----------------------TDGPDAQLDVAVFDVLILDLDALAAPAPPP--------PVDVAPDDLAY- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 274 qqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQlRMILPNPLYHCLgSVAGTMMCLMYGAT 353
Cdd:cd12114 131 -----------VIFTSGSTGTPKGVMISHRAALNTILDINRRFAV---GPDD-RVLALSSLSFDL-SVYDIFGALSAGAT 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 354 LILASPIFNGKKA--LEAISRERGTFLYGTPT---MFVDIL--NQPDFSSYDISTMCGGVIAgsPAPPELIRAIINKINm 426
Cdd:cd12114 195 LVLPDEARRRDPAhwAELIERHGVTLWNSVPAlleMLLDVLeaAQALLPSLRLVLLSGDWIP--LDLPARLRALAPDAR- 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 427 kdLVVAYGTTENSPVTFAHfPEDTVEQKAESV--GRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKT 504
Cdd:cd12114 272 --LISLGGATEASIWSIYH-PIDEVPPDWRSIpyGRPLANQRYRVLD-PRGRDCPDWVPGELWIGGRGVALGYLGDPELT 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 505 EEA----VDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVkDDRMGEEICAC 580
Cdd:cd12114 348 AARfvthPDGERLYRTGDLGRYRPDGTLEFLGRRDGQVKVRGYRIELGEIEAALQAHPGVARAVVVVL-GDPGGKRLAAF 426
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 572872742 581 IRLK-DGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:cd12114 427 VVPDnDGTPIAPDALRAFLAQTLPAYMIPSRVIALEALPLTANGKV 472
|
|
| A_NRPS_ACVS-like |
cd17648 |
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ... |
111-625 |
2.57e-26 |
|
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV synthetase (ACVS, EC 6.3.2.26; also known as N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase or delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase) is involved in medically important antibiotic biosynthesis. ACV synthetase is active in an early step in the penicillin G biosynthesis pathway which involves the formation of the tripeptide 6-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV); each of the constituent amino acids of the tripeptide ACV are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates. ACV is then cyclized by the action of isopenicillin N synthase.
Pssm-ID: 341303 [Multi-domain] Cd Length: 453 Bit Score: 112.49 E-value: 2.57e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 111 PEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRL-GMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELE 189
Cdd:cd17648 1 PDRVAVV--YGDKRLTYRELNERANRLAHYLLSVAEIRPDDLvGLVLDKSELMIIAILAVWKAGAAYVPIDPSYPDERIQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 190 YVLKKVGCKALVfpkqfktqqyynvlkqicpevenaqpgalksqrlpdlttvisvdaplpgtllldevvaAGSTrqhldQ 269
Cdd:cd17648 79 FILEDTGARVVI----------------------------------------------------------TNST-----D 95
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 270 LQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLrMILPNplYHCLGSVAGTMMCLM 349
Cdd:cd17648 96 LAY------------AIYTSGTTGKPKGVLVEHGSVVNLRTSLSERYFGRDNGDEAV-LFFSN--YVFDFFVEQMTLALL 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 350 YGATLILASPIFNGKKA--LEAISRERGTFLYGTPTmfvdILNQPDFSSYDISTMcggVIAgspAPPELIRAIINKI--N 425
Cdd:cd17648 161 NGQKLVVPPDEMRFDPDrfYAYINREKVTYLSGTPS----VLQQYDLARLPHLKR---VDA---AGEEFTAPVFEKLrsR 230
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 426 MKDLVV-AYGTTENSpVTFAHFPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKT 504
Cdd:cd17648 231 FAGLIInAYGPTETT-VTNHKRFFPGDQRFDKSLGRPVRNTKCYVLN-DAMKRVPVGAVGELYLGGDGVARGYLNRPELT 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 505 EE-------AVDQDKW-------YWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKD 570
Cdd:cd17648 309 AErflpnpfQTEQERArgrnarlYKTGDLVRWLPSGELEYLGRNDFQVKIRGQRIEPGEVEAALASYPGVRECAVVAKED 388
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 572872742 571 DRMGEEICA----CIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:cd17648 389 ASQAQSRIQkylvGYYLPEPGHVPESDLLSFLRAKLPRYMVPARLVRLEGIPVTINGKL 447
|
|
| PrpE |
cd05967 |
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ... |
124-625 |
4.87e-26 |
|
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency.
Pssm-ID: 341271 [Multi-domain] Cd Length: 617 Bit Score: 113.18 E-value: 4.87e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 124 RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIIlvsvnpayqameleyvlkkvgcKALVFp 203
Cdd:cd05967 82 TYTYAELLDEVSRLAGVLRKLGVVKGDRVIIYMPMIPEAAIAMLACARIGAI----------------------HSVVF- 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 204 KQFKTqqyynvlKQICPEVENAQP--------GALKSQRLPDLTTV-----ISVDAPlPGTLLLDEVVAAGSTRQHLDQL 270
Cdd:cd05967 139 GGFAA-------KELASRIDDAKPklivtascGIEPGKVVPYKPLLdkaleLSGHKP-HHVLVLNRPQVPADLTKPGRDL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 271 QYNQQFLSC----------HDPINIQFTSGTTGSPKG--------ATLSHYNIvnnSNILGerlklhektpeqlrmILPN 332
Cdd:cd05967 211 DWSELLAKAepvdcvpvaaTDPLYILYTSGTTGKPKGvvrdngghAVALNWSM---RNIYG---------------IKPG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 333 PLYHC---LGSVAG-TMMC---LMYGATLILaspiFNGKKA--------LEAISRERGTFLYGTPTMFVDILNQP----D 393
Cdd:cd05967 273 DVWWAasdVGWVVGhSYIVygpLLHGATTVL----YEGKPVgtpdpgafWRVIEKYQVNALFTAPTAIRAIRKEDpdgkY 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 394 FSSYDISTMCGGVIAGSPAPPELIRAIINKINmKDLVVAYGTTEN-SPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNm 472
Cdd:cd05967 349 IKKYDLSSLRTLFLAGERLDPPTLEWAENTLG-VPVIDHWWQTETgWPITANPVGLEPLPIKAGSPGKPVPGYQVQVLD- 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 473 EAGTLAKLNTPGELCIRGYC---VMLGYWGEPQKTEEAV--DQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYP 547
Cdd:cd05967 427 EDGEPVGPNELGNIVIKLPLppgCLLTLWKNDERFKKLYlsKFPGYYDTGDAGYKDEDGYLFIMGRTDDVINVAGHRLST 506
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 548 AELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDG----EETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISG 623
Cdd:cd05967 507 GEMEESVLSHPAVAECAVVGVRDELKGQVPLGLVVLKEGvkitAEELEKELVALVREQIGPVAAFRLVIFVKRLPKTRSG 586
|
..
gi 572872742 624 KI 625
Cdd:cd05967 587 KI 588
|
|
| PRK05857 |
PRK05857 |
fatty acid--CoA ligase; |
93-630 |
9.97e-26 |
|
fatty acid--CoA ligase;
Pssm-ID: 180293 [Multi-domain] Cd Length: 540 Bit Score: 111.64 E-value: 9.97e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 93 HLNSKTVGQCLETtAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDR---LGMWGPNSYawvLMQLAT 169
Cdd:PRK05857 11 QLPSTVLDRVFEQ-ARQQPEAIALRRCDGTSALRYRELVAEVGGLAADLRAQSVSRGSRvlvISDNGPETY---LSVLAC 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 170 AQAGIILVSVNPAYQAMELEYvlkkvgckalvfpkqfktqqyynvLKQIC--PEVENAQPGALKSQRLPDLTTVISvdap 247
Cdd:PRK05857 87 AKLGAIAVMADGNLPIAAIER------------------------FCQITdpAAALVAPGSKMASSAVPEALHSIP---- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 248 lpgTLLLDEVVAAGSTRQHLDQLQYNQQF-LSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGErlklhektpEQL 326
Cdd:PRK05857 139 ---VIAVDIAAVTRESEHSLDAASLAGNAdQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQK---------EGL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 327 RMI---------LPNPLYHcLGSVAGTMMCLMYGATLILASPifNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSY 397
Cdd:PRK05857 207 NWVtwvvgettySPLPATH-IGGLWWILTCLMHGGLCVTGGE--NTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANA 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 398 DISTMCGGVIAGSPAppelIRAIINKINMKDLVVA--YGTTENSpVTFAHFPEDT-----VEQKAesVGRIMPHTEARIM 470
Cdd:PRK05857 284 TVPSLRLVGYGGSRA----IAADVRFIEATGVRTAqvYGLSETG-CTALCLPTDDgsivkIEAGA--VGRPYPGVDVYLA 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 471 NMEAG-----TLAKLNTPGELCIRGYCVMLGYWGEPQKTEEaVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENI 545
Cdd:PRK05857 357 ATDGIgptapGAGPSASFGTLWIKSPANMLGYWNNPERTAE-VLIDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNI 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 546 YPAELEDFFHTHPKVQEVQVVGVKDDRMGEEI-CACIRLKDGEETTVEEIK----AFCKGKISHFKIPKYIVFVTNYPLT 620
Cdd:PRK05857 436 APDEVDRIAEGVSGVREAACYEIPDEEFGALVgLAVVASAELDESAARALKhtiaARFRRESEPMARPSTIVIVTDIPRT 515
|
570
....*....|
gi 572872742 621 ISGKIQKFKL 630
Cdd:PRK05857 516 QSGKVMRASL 525
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
97-627 |
1.02e-25 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 113.72 E-value: 1.02e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 97 KTVGQCLETTAQRVPEREALVVlhEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIIL 176
Cdd:PRK12467 3095 RLVHQLIEAQVARTPEAPALVF--GDQQLSYAELNRRANRLAHRLIAIGVGPDVLVGVAVERSVEMIVALLAVLKAGGAY 3172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 177 VSVNPAYQAMELEYVLKKVGCKALVfpkqfkTQQyyNVLkqicpevenaqpgalksQRLPDLTTVIsvdaplpgTLLLDE 256
Cdd:PRK12467 3173 VPLDPEYPRERLAYMIEDSGVKLLL------TQA--HLL-----------------EQLPAPAGDT--------ALTLDR 3219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 257 VVAAG------STRQHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMIl 330
Cdd:PRK12467 3220 LDLNGysennpSTRVMGENLAY------------VIYTSGSTGKPKGVGVRHGALANHLCWIAEAYELDANDRVLLFMS- 3286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 331 pnplYHCLGSVAGTMMCLMYGATLILA-SPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSY-DISTMCGGvia 408
Cdd:PRK12467 3287 ----FSFDGAQERFLWTLICGGCLVVRdNDLWDPEELWQAIHAHRISIACFPPAYLQQFAEDAGGADCaSLDIYVFG--- 3359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 409 GSPAPPELIRAIINKINMKDLVVAYGTTEnSPVTFAHF--PEDTV-EQKAESVGRIMPHTEARIMNMEAGTLAkLNTPGE 485
Cdd:PRK12467 3360 GEAVPPAAFEQVKRKLKPRGLTNGYGPTE-AVVTVTLWkcGGDAVcEAPYAPIGRPVAGRSIYVLDGQLNPVP-VGVAGE 3437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 486 LCIRGYCVMLGYWGEPQKTEEAVDQD-------KWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHP 558
Cdd:PRK12467 3438 LYIGGVGLARGYHQRPSLTAERFVADpfsgsggRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIEARLLQHP 3517
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 572872742 559 KVQEVQVVGVkDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 627
Cdd:PRK12467 3518 SVREAVVLAR-DGAGGKQLVAYVVPADPQGDWRETLRDHLAASLPDYMVPAQLLVLAAMPLGPNGKVDR 3585
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
96-627 |
1.16e-25 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 113.51 E-value: 1.16e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 96 SKTVGQCLETTAQRVPEreALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGII 175
Cdd:PRK12316 4550 TRCVHQLVAERARMTPD--AVAVVFDEEKLTYAELNRRANRLAHALIARGVGPEVLVGIAMERSAEMMVGLLAVLKAGGA 4627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 176 LVSVNPAYQAMELEYVLKKVGCKALVfpkqfkTQQYYnvlkqicpevenaqpgalkSQRLPdlttvisvdaplpgtllld 255
Cdd:PRK12316 4628 YVPLDPEYPRERLAYMMEDSGAALLL------TQSHL-------------------LQRLP------------------- 4663
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 256 evVAAGSTRQHLDQLQYNQQFlSCHDPIN---------IQFTSGTTGSPKGATLSHYNIVNNSNILGERlklHEKTPEQL 326
Cdd:PRK12316 4664 --IPDGLASLALDRDEDWEGF-PAHDPAVrlhpdnlayVIYTSGSTGRPKGVAVSHGSLVNHLHATGER---YELTPDDR 4737
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 327 RMILPNplYHCLGSVAGTMMCLMYGATLILASP-IFNGKKALEAISRERGTFLYGTPTMFVDILNQP--DFSSYDISTMC 403
Cdd:PRK12316 4738 VLQFMS--FSFDGSHEGLYHPLINGASVVIRDDsLWDPERLYAEIHEHRVTVLVFPPVYLQQLAEHAerDGEPPSLRVYC 4815
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 404 GGviaGSPAPPELIRAIINKINMKDLVVAYGTTENS--PVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAkLN 481
Cdd:PRK12316 4816 FG---GEAVAQASYDLAWRALKPVYLFNGYGPTETTvtVLLWKARDGDACGAAYMPIGTPLGNRSGYVLDGQLNPLP-VG 4891
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 482 TPGELCIRGYCVMLGYWGEPQKTEEAVDQD-------KWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGEnIYPAELEDF 553
Cdd:PRK12316 4892 VAGELYLGGEGVARGYLERPALTAERFVPDpfgapggRLYRTGDLARYRADGVIDYLGRVDHQVkIRGFR-IELGEIEAR 4970
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 554 FHTHPKVQEVQVVGVkDDRMGEEICACI-----RLKDGEETTVE---EIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:PRK12316 4971 LREHPAVREAVVIAQ-EGAVGKQLVGYVvpqdpALADADEAQAElrdELKAALRERLPEYMVPAHLVFLARMPLTPNGKL 5049
|
..
gi 572872742 626 QK 627
Cdd:PRK12316 5050 DR 5051
|
|
| entE |
PRK10946 |
(2,3-dihydroxybenzoyl)adenylate synthase; |
448-638 |
2.60e-25 |
|
(2,3-dihydroxybenzoyl)adenylate synthase;
Pssm-ID: 236803 [Multi-domain] Cd Length: 536 Bit Score: 110.46 E-value: 2.60e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 448 EDTVEQKAESVGRIM-PHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQG 526
Cdd:PRK10946 345 DDSDERIFTTQGRPMsPDDEVWVAD-ADGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLVSIDPDG 423
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 527 FCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVeeIKAFCKGK-ISHF 605
Cdd:PRK10946 424 YITVVGREKDQINRGGEKIAAEEIENLLLRHPAVIHAALVSMEDELMGEKSCAFLVVKEPLKAVQ--LRRFLREQgIAEF 501
|
170 180 190
....*....|....*....|....*....|...
gi 572872742 606 KIPKYIVFVTNYPLTISGKIQKFKLREQMERHL 638
Cdd:PRK10946 502 KLPDRVECVDSLPLTAVGKVDKKQLRQWLASRA 534
|
|
| A_NRPS_MycA_like |
cd05908 |
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin ... |
285-635 |
2.61e-25 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPS similar to mycosubtilin synthase subunit A (MycA). Mycosubtilin, which is characterized by a beta-amino fatty acid moiety linked to the circular heptapeptide Asn-Tyr-Asn-Gln-Pro-Ser-Asn, belongs to the iturin family of lipopeptide antibiotics. The mycosubtilin synthase subunit A (MycA) combines functional domains derived from peptide synthetases, amino transferases, and fatty acid synthases. Nonribosomal peptide synthetases are large multifunction enzymes that synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341234 [Multi-domain] Cd Length: 499 Bit Score: 109.89 E-value: 2.61e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 285 IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGA-------TLILA 357
Cdd:cd05908 111 IQFSSGSTGDPKGVMLTHENLVHNMFAILNSTEWKTKD----RILSWMPLTHDMGLIAFHLAPLIAGMnqylmptRLFIR 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 358 SPIFNGKKALE--AISRERGTFLYgtpTMFVDILNQPDFSSYDISTMcGGVIAGS-PAPPELIRAIIN---KINMKD--L 429
Cdd:cd05908 187 RPILWLKKASEhkATIVSSPNFGY---KYFLKTLKPEKANDWDLSSI-RMILNGAePIDYELCHEFLDhmsKYGLKRnaI 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 430 VVAYGTTENS-------------PVTFAH------FPEDTVEQKAE------SVGRIMPHTEARIMNMEAGTLAKlNTPG 484
Cdd:cd05908 263 LPVYGLAEASvgaslpkaqspfkTITLGRrhvthgEPEPEVDKKDSecltfvEVGKPIDETDIRICDEDNKILPD-GYIG 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 485 ELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEqGFCKIVGRSKDMIIRGGENIYPAELEDFfhthpkvqEVQ 564
Cdd:cd05908 342 HIQIRGKNVTPGYYNNPEATAKVFTDDGWLKTGDLGFIRN-GRLVITGREKDIIFVNGQNVYPHDIERI--------AEE 412
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 565 VVGVKDDRMGeeICACirlkDGEETTVEEIKAFC--KGKISHF-----KIPKY-----------IVFVTNYPLTISGKIQ 626
Cdd:cd05908 413 LEGVELGRVV--ACGV----NNSNTRNEEIFCFIehRKSEDDFyplgkKIKKHlnkrggwqineVLPIRRIPKTTSGKVK 486
|
....*....
gi 572872742 627 KFKLREQME 635
Cdd:cd05908 487 RYELAQRYQ 495
|
|
| A_NRPS_CmdD_like |
cd17652 |
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ... |
111-630 |
3.13e-25 |
|
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes phosphinothricin tripeptide (PTT, phosphinothricylalanylalanine) synthetase, where PTT is a natural-product antibiotic and potent herbicide that is produced by Streptomyces hygroscopicus. This adenylation domain has been confirmed to directly activate beta-tyrosine, and fluorinated chondramides are produced through precursor-directed biosynthesis. Also included in this family is chondramide synthase D (also known as ATP-dependent phenylalanine adenylase or phenylalanine activase or tyrosine activase). Chondramides A-D are depsipeptide antitumor and antifungal antibiotics produced by C. crocatus, are a class of mixed peptide/polyketide depsipeptides comprised of three amino acids (alanine, N-methyltryptophan, plus the unusual amino acid beta-tyrosine or alpha-methoxy-beta-tyrosine) and a polyketide chain ([E]-7-hydroxy-2,4,6-trimethyloct-4-enoic acid).
Pssm-ID: 341307 [Multi-domain] Cd Length: 436 Bit Score: 108.88 E-value: 3.13e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 111 PEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEY 190
Cdd:cd17652 1 PDAPAVV--FGDETLTYAELNARANRLARLLAARGVGPERLVALALPRSAELVVAILAVLKAGAAYLPLDPAYPAERIAY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 191 VLkkvgckalvfpkqfktqqyynvlkqicpevENAQPGALksqrlpdLTTVisvdaplpgtllldevvaagstrqhlDQL 270
Cdd:cd17652 79 ML------------------------------ADARPALL-------LTTP--------------------------DNL 95
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 271 QYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQLRMILPNPLYHclGSVAGTMMCLMY 350
Cdd:cd17652 96 AY------------VIYTSGSTGRPKGVVVTHRGLANLAAAQIAAFDV---GPGSRVLQFASPSFD--ASVWELLMALLA 158
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 351 GATLILA--SPIFNGKKALEAISRERGTFLYGTPTMfVDILnqPDFSSYDISTMcggVIAGSPAPPELI------RAIIN 422
Cdd:cd17652 159 GATLVLApaEELLPGEPLADLLREHRITHVTLPPAA-LAAL--PPDDLPDLRTL---VVAGEACPAELVdrwapgRRMIN 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 423 kinmkdlvvAYGTTE---NSPVTFAHFPEDTVeqkaeSVGRIMPHTEARIMNmeagtlAKLN-----TPGELCIRGYCVM 494
Cdd:cd17652 233 ---------AYGPTEttvCATMAGPLPGGGVP-----PIGRPVPGTRVYVLD------ARLRpvppgVPGELYIAGAGLA 292
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 495 LGYWGEPQKTEEAVDQD-------KWYWTGDVATMNEQGFCKIVGRSKDMI-IRGgENIYPAELEDFFHTHPKVQEVqVV 566
Cdd:cd17652 293 RGYLNRPGLTAERFVADpfgapgsRMYRTGDLARWRADGQLEFLGRADDQVkIRG-FRIELGEVEAALTEHPGVAEA-VV 370
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572872742 567 GVKDDRMGEE-ICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 630
Cdd:cd17652 371 VVRDDRPGDKrLVAYVVPAPGAAPTAAELRAHLAERLPGYMVPAAFVVLDALPLTPNGKLDRRAL 435
|
|
| LC_FACS_euk1 |
cd17639 |
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The ... |
125-567 |
7.58e-25 |
|
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The members of this family are eukaryotic fatty acid CoA synthetases (EC 6.2.1.3) that activate fatty acids with chain lengths of 12 to 20 and includes fungal proteins. They act on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. In Schizosaccharomyces pombe, lcf1 gene encodes a new fatty acyl-CoA synthetase that preferentially recognizes myristic acid as a substrate.
Pssm-ID: 341294 [Multi-domain] Cd Length: 507 Bit Score: 108.46 E-value: 7.58e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 125 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALvfpk 204
Cdd:cd17639 6 MSYAEVWERVLNFGRGLVELGLKPGDKVAIFAETRAEWLITALGCWSQNIPIVTVYATLGEDALIHSLNETECSAI---- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 205 qfktqqyynvlkqICPEvenaqpgalksqrlpdlttvisvdaplpgtllldevvaagstrqhldqlqynqqflSCHDPIN 284
Cdd:cd17639 82 -------------FTDG--------------------------------------------------------KPDDLAC 92
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 285 IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMILPnpLYHCLgSVAGTMMCLMYGATLILASP----- 359
Cdd:cd17639 93 IMYTSGSTGNPKGVMLTHGNLVAGIAGLGDRVPELLGPDDRYLAYLP--LAHIF-ELAAENVCLYRGGTIGYGSPrtltd 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 360 ----------------IFNG--------KKALEAISRERGTF------------------LYGTPtmfvdILNQPDFSSy 397
Cdd:cd17639 170 kskrgckgdltefkptLMVGvpaiwdtiRKGVLAKLNPMGGLkrtlfwtayqsklkalkeGPGTP-----LLDELVFKK- 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 398 dISTMCGGVIA-----GSPAPPELIRAIinKINMKDLVVAYGTTENSPVTFAHFPEDtveQKAESVGRIMPHTEARIMNM 472
Cdd:cd17639 244 -VRAALGGRLRymlsgGAPLSADTQEFL--NIVLCPVIQGYGLTETCAGGTVQDPGD---LETGRVGPPLPCCEIKLVDW 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 473 -EAGTLAKLNTP-GELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGENIYPAE 549
Cdd:cd17639 318 eEGGYSTDKPPPrGEILIRGPNVFKGYYKNPEKTKEAFDGDGWFHTGDIGEFHPDGTLKIIDRKKDLVkLQNGEYIALEK 397
|
490
....*....|....*...
gi 572872742 550 LEDFFHTHPKVQEVQVVG 567
Cdd:cd17639 398 LESIYRSNPLVNNICVYA 415
|
|
| PRK04813 |
PRK04813 |
D-alanine--poly(phosphoribitol) ligase subunit DltA; |
103-625 |
3.22e-24 |
|
D-alanine--poly(phosphoribitol) ligase subunit DltA;
Pssm-ID: 235313 [Multi-domain] Cd Length: 503 Bit Score: 106.52 E-value: 3.22e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVVLHEdvRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNpa 182
Cdd:PRK04813 8 IEEFAQTQPDFPAYDYLGE--KLTYGQLKEDSDALAAFIDSLKLPDKSPIIVFGHMSPEMLATFLGAVKAGHAYIPVD-- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 yQAMELEYVLkkvgckalvfpkqfktqqyynvlkQIcpeVENAQPGALKSqrlPDLTTVISVDAPlpgTLLLDEVVAAGS 262
Cdd:PRK04813 84 -VSSPAERIE------------------------MI---IEVAKPSLIIA---TEELPLEILGIP---VITLDELKDIFA 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 263 TRQHLDQlqynQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILgerLKLHEkTPEQLRMiLPNPLYHCLGSVA 342
Cdd:PRK04813 130 TGNPYDF----DHAVKGDDNYYIIFTSGTTGKPKGVQISHDNLVSFTNWM---LEDFA-LPEGPQF-LNQAPYSFDLSVM 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 343 GTMMCLMYGATLILASP--IFNGKKALEAISRERGTFLYGTPTmFVDI-LNQPDFSSYDISTM-----CGGVIAGSPAPP 414
Cdd:PRK04813 201 DLYPTLASGGTLVALPKdmTANFKQLFETLPQLPINVWVSTPS-FADMcLLDPSFNEEHLPNLthflfCGEELPHKTAKK 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 415 ELIR----AIINkinmkdlvvAYGTTENS-PVTFAHFPEDTVEQKAE-SVGRIMPHTEARIMnMEAGTLAKLNTPGELCI 488
Cdd:PRK04813 280 LLERfpsaTIYN---------TYGPTEATvAVTSIEITDEMLDQYKRlPIGYAKPDSPLLII-DEEGTKLPDGEQGEIVI 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 489 RGYCVMLGYWGEPQKTEEA---VDQDKWYWTGDVATM-NEQGFCKivGRSkDMIIRggENIYPAELEDFFHTHPKVQEVQ 564
Cdd:PRK04813 350 SGPSVSKGYLNNPEKTAEAfftFDGQPAYHTGDAGYLeDGLLFYQ--GRI-DFQIK--LNGYRIELEEIEQNLRQSSYVE 424
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 572872742 565 ---VVGVKDDRMGEEICACIRLKDG----EETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:PRK04813 425 savVVPYNKDHKVQYLIAYVVPKEEdferEFELTKAIKKELKERLMEYMIPRKFIYRDSLPLTPNGKI 492
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
89-627 |
5.60e-24 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 108.12 E-value: 5.60e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 89 CTKKHLNSKTVGQCLETTAQRVPEREALVVlhEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLA 168
Cdd:PRK12316 3049 TAAEYPLERGVHRLFEEQVERTPDAVALAF--GEQRLSYAELNRRANRLAHRLIERGVGPDVLVGVAVERSLEMVVGLLA 3126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 169 TAQAGIILVSVNPAYQAMELEYVLKKVGCKALVFPKQFKTQQYYNVlKQICPEvenAQPGALKSQRLPDLTTVisvdapl 248
Cdd:PRK12316 3127 ILKAGGAYVPLDPEYPEERLAYMLEDSGAQLLLSQSHLRLPLAQGV-QVLDLD---RGDENYAEANPAIRTMP------- 3195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 249 pgtllldevvaagstrqhlDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlrM 328
Cdd:PRK12316 3196 -------------------ENLAY------------VIYTSGSTGKPKGVGIRHSALSNHLCWMQQAYGLGVGD-----R 3239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 329 ILPNPLYHCLGSVAGTMMCLMYGATLILASP--IFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCggV 406
Cdd:PRK12316 3240 VLQFTTFSFDVFVEELFWPLMSGARVVLAGPedWRDPALLVELINSEGVDVLHAYPSMLQAFLEEEDAHRCTSLKRI--V 3317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 407 IAGSPAPPELIRAIINKInmkDLVVAYGTTEnSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGEL 486
Cdd:PRK12316 3318 CGGEALPADLQQQVFAGL---PLYNLYGPTE-ATITVTHWQCVEEGKDAVPIGRPIANRACYILD-GSLEPVPVGALGEL 3392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 487 CIRGYCVMLGYWGEPQKTEEAVDQD------KWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKV 560
Cdd:PRK12316 3393 YLGGEGLARGYHNRPGLTAERFVPDpfvpgeRLYRTGDLARYRADGVIEYIGRVDHQVKIRGFRIELGEIEARLLEHPWV 3472
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 572872742 561 QEVQVVGVKddrmGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 627
Cdd:PRK12316 3473 REAVVLAVD----GRQLVAYVVPEDEAGDLREALKAHLKASLPEYMVPAHLLFLERMPLTPNGKLDR 3535
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
99-630 |
8.29e-24 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 107.74 E-value: 8.29e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 99 VGQCLETTAQRVPEreALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVS 178
Cdd:PRK12316 2005 VHQRIAEQAARAPE--AIAVVFGDQHLSYAELDSRANRLAHRLRARGVGPEVRVAIAAERSFELVVALLAVLKAGGAYVP 2082
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 179 VNPAYQAMELEYVLKKVGCKALVfpkqfktqqyynvlkqicpevenAQPGALKSQRLPDLTTVISVDAPLPgtlLLDEVV 258
Cdd:PRK12316 2083 LDPNYPAERLAYMLEDSGAALLL-----------------------TQRHLLERLPLPAGVARLPLDRDAE---WADYPD 2136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 259 AAGSTRQHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMIlpnplYHCL 338
Cdd:PRK12316 2137 TAPAVQLAGENLAY------------VIYTSGSTGLPKGVAVSHGALVAHCQAAGERYELSPADCELQFMS-----FSFD 2199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 339 GSVAGTMMCLMYGATLIL-ASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQP--DFSSYDISTMCGGviaGSPAPPE 415
Cdd:PRK12316 2200 GAHEQWFHPLLNGARVLIrDDELWDPEQLYDEMERHGVTILDFPPVYLQQLAEHAerDGRPPAVRVYCFG---GEAVPAA 2276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 416 LIRAIINKINMKDLVVAYGTTENSPVTFAHF--PEDTVEQKAESVGRIMPHTEARIMNMEAGTLAkLNTPGELCIRGYCV 493
Cdd:PRK12316 2277 SLRLAWEALRPVYLFNGYGPTEAVVTPLLWKcrPQDPCGAAYVPIGRALGNRRAYILDADLNLLA-PGMAGELYLGGEGL 2355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 494 MLGYWGEPQKTEEAVDQDKW-------YWTGDVATMNEQGFCKIVGRSKDMI-IRGGEnIYPAELEDFFHTHPKVQEVQV 565
Cdd:PRK12316 2356 ARGYLNRPGLTAERFVPDPFsasgerlYRTGDLARYRADGVVEYLGRIDHQVkIRGFR-IELGEIEARLQAHPAVREAVV 2434
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572872742 566 VGvKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 630
Cdd:PRK12316 2435 VA-QDGASGKQLVAYVVPDDAAEDLLAELRAWLAARLPAYMVPAHWVVLERLPLNPNGKLDRKAL 2498
|
|
| AACS |
cd05943 |
Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that ... |
109-626 |
1.12e-23 |
|
Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms. AACS is widely distributed in bacteria, archaea and eukaryotes. In bacteria, AACS is known to exhibit an important role in the metabolism of poly-b-hydroxybutyrate, an intracellular reserve of organic carbon and chemical energy by some microorganisms. In mammals, AACS influences the rate of ketone body utilization for the formation of physiologically important fatty acids and cholesterol.
Pssm-ID: 341265 [Multi-domain] Cd Length: 629 Bit Score: 105.82 E-value: 1.12e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 109 RVPEREALVVLHED---VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQA 185
Cdd:cd05943 80 ADADDPAAIYAAEDgerTEVTWAELRRRVARLAAALRALGVKPGDRVAGYLPNIPEAVVAMLATASIGAIWSSCSPDFGV 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 186 melEYVLKKVGckaLVFPK-QFKTQQY-YNVlKQIC--PEVENAQPGalksqrLPDLTTVISVD----------APLPGT 251
Cdd:cd05943 160 ---PGVLDRFG---QIEPKvLFAVDAYtYNG-KRHDvrEKVAELVKG------LPSLLAVVVVPytvaagqpdlSKIAKA 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 252 LLLDEVVAAGSTRQ-HLDQLQYNqqflschDPINIQFTSGTTGSPKGATLSHynivnnSNILGERLKLHektpeqlrmIL 330
Cdd:cd05943 227 LTLEDFLATGAAGElEFEPLPFD-------HPLYILYSSGTTGLPKCIVHGA------GGTLLQHLKEH---------IL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 331 PNPLYH----CLGSVAGTMM------CLMYGATLIL--ASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFS--- 395
Cdd:cd05943 285 HCDLRPgdrlFYYTTCGWMMwnwlvsGLAVGATIVLydGSPFYPDTNALWDLADEEGITVFGTSAKYLDALEKAGLKpae 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 396 SYDISTMCGGVIAGSPAPPELIRAIINKINmKDLVVAY---GTTENSpvTFA-HFPEDTV---EQKAESVGRIMphteaR 468
Cdd:cd05943 365 THDLSSLRTILSTGSPLKPESFDYVYDHIK-PDVLLASisgGTDIIS--CFVgGNPLLPVyrgEIQCRGLGMAV-----E 436
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 469 IMNmEAGTlAKLNTPGEL-CIRGY-CVMLGYWGEP--QKTEEA-VDQDKWYWT-GDVATMNEQGFCKIVGRSKDMIIRGG 542
Cdd:cd05943 437 AFD-EEGK-PVWGEKGELvCTKPFpSMPVGFWNDPdgSRYRAAyFAKYPGVWAhGDWIEITPRGGVVILGRSDGTLNPGG 514
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 543 ENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETT---VEEIKAFCKGKISHFKIPKYIVFVTNYPL 619
Cdd:cd05943 515 VRIGTAEIYRVVEKIPEVEDSLVVGQEWKDGDERVILFVKLREGVELDdelRKRIRSTIRSALSPRHVPAKIIAVPDIPR 594
|
....*..
gi 572872742 620 TISGKIQ 626
Cdd:cd05943 595 TLSGKKV 601
|
|
| LC_FACS_bac1 |
cd17641 |
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial ... |
126-578 |
1.97e-23 |
|
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341296 [Multi-domain] Cd Length: 569 Bit Score: 104.81 E-value: 1.97e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 126 TFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVnpaYQ---AMELEYVLKKVGCKALVF 202
Cdd:cd17641 13 TWADYADRVRAFALGLLALGVGRGDVVAILGDNRPEWVWAELAAQAIGALSLGI---YQdsmAEEVAYLLNYTGARVVIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 203 PKQFKTQQYYNVLKQIcPEVENA---QPGALKSQRLPDLttvisvdaplpgtLLLDEVVAAGSTRQHLDQLQYNQQFLSC 279
Cdd:cd17641 90 EDEEQVDKLLEIADRI-PSVRYViycDPRGMRKYDDPRL-------------ISFEDVVALGRALDRRDPGLYEREVAAG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 280 H--DPINIQFTSGTTGSPKGATLSHYNIVNNSNILgerLKLHEKTP-EQLRMILPNP-----------------LYHCLG 339
Cdd:cd17641 156 KgeDVAVLCTTSGTTGKPKLAMLSHGNFLGHCAAY---LAADPLGPgDEYVSVLPLPwigeqmysvgqalvcgfIVNFPE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 340 SVAgTMMCLM--YGATLILASP-----------------------IFN-----GKKALEAISRER--GTFLYGTPTMFVD 387
Cdd:cd17641 233 EPE-TMMEDLreIGPTFVLLPPrvwegiaadvrarmmdatpfkrfMFElgmklGLRALDRGKRGRpvSLWLRLASWLADA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 388 ILNQPDFSSYDISTMCGGVIAGSPAPPELIR---AIinKINMKDLvvaYGTTENSPVTFAHfPEDTVeqKAESVGRIMPH 464
Cdd:cd17641 312 LLFRPLRDRLGFSRLRSAATGGAALGPDTFRffhAI--GVPLKQL---YGQTELAGAYTVH-RDGDV--DPDTVGVPFPG 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 465 TEARIMNMeagtlaklntpGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKD-MIIRGGE 543
Cdd:cd17641 384 TEVRIDEV-----------GEILVRSPGVFVGYYKNPEATAEDFDEDGWLHTGDAGYFKENGHLVVIDRAKDvGTTSDGT 452
|
490 500 510
....*....|....*....|....*....|....*
gi 572872742 544 NIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEIC 578
Cdd:cd17641 453 RFSPQFIENKLKFSPYIAEAVVLGAGRPYLTAFIC 487
|
|
| MACS_like_1 |
cd05974 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
248-632 |
3.39e-23 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341278 [Multi-domain] Cd Length: 432 Bit Score: 102.65 E-value: 3.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 248 LPGTLLL------DEVVAAGSTRQHLDQLQYnqqflsCHDPINIQFTSGTTGSPKGATLSH--YNIVNNSNILGERLKlh 319
Cdd:cd05974 53 IPATTLLtpddlrDRVDRGGAVYAAVDENTH------ADDPMLLYFTSGTTSKPKLVEHTHrsYPVGHLSTMYWIGLK-- 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 320 ektPEQLRMILPNPlyhclGSVAGTMMCLM----YGATLILAS-PIFNGKKALEAISRERGTFLYGTPTMFvDILNQPDF 394
Cdd:cd05974 125 ---PGDVHWNISSP-----GWAKHAWSCFFapwnAGATVFLFNyARFDAKRVLAALVRYGVTTLCAPPTVW-RMLIQQDL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 395 SSYDIS--TMCGgviAGSPAPPELIRAIINK--INMKDlvvAYGTTENSpVTFAHFPEDTVeqKAESVGRIMPHTEARIM 470
Cdd:cd05974 196 ASFDVKlrEVVG---AGEPLNPEVIEQVRRAwgLTIRD---GYGQTETT-ALVGNSPGQPV--KAGSMGRPLPGYRVALL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 471 NMEAGTLAKlntpGELCI-----RGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENI 545
Cdd:cd05974 267 DPDGAPATE----GEVALdlgdtRPVGLMKGYAGDPDKTAHAM-RGGYYRTGDIAMRDEDGYLTYVGRADDVFKSSDYRI 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 546 YPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVE---EIKAFCKGKISHFKIPKYIVFVtNYPLTIS 622
Cdd:cd05974 342 SPFELESVLIEHPAVAEAAVVPSPDPVRLSVPKAFIVLRAGYEPSPEtalEIFRFSRERLAPYKRIRRLEFA-ELPKTIS 420
|
410
....*....|
gi 572872742 623 GKIQKFKLRE 632
Cdd:cd05974 421 GKIRRVELRR 430
|
|
| A_NRPS_Cytc1-like |
cd17643 |
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ... |
111-627 |
3.97e-23 |
|
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Streptomyces sp. cytotrienin synthetase (CytC1), a relatively promiscuous adenylation enzyme that installs the aminoacyl moieties on the phosphopantetheinyl arm of the holo carrier protein CytC2. Also included are Streptomyces sp Thr1, involved in the biosynthesis of 4-chlorothreonine, Pseudomonas aeruginosa pyoverdine synthetase D (PvdD), involved in the biosynthesis of the siderophore pyoverdine and Pseudomonas syringae syringopeptin synthetase, where syringpeptin is a necrosis-inducing phytotoxin that functions as a virulence determinant in the plant-pathogen interaction. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 102.77 E-value: 3.97e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 111 PEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEY 190
Cdd:cd17643 1 PEAVAVV--DEDRRLTYGELDARANRLARTLRAEGVGPGDRVALALPRSAELIVALLAILKAGGAYVPIDPAYPVERIAF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 191 VLkkvgckalvfpkqfktqqyynvlkqicpevENAQPgalksqrlpdlttvisvdaplpgTLLLDEVvaagstrqhlDQL 270
Cdd:cd17643 79 IL------------------------------ADSGP-----------------------SLLLTDP----------DDL 95
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 271 QYnqqflschdpinIQFTSGTTGSPKGATLSHYNIvnnsnilgerLKLHEKTPEQLRMilpNP-----LYHCLG---SVA 342
Cdd:cd17643 96 AY------------VIYTSGSTGRPKGVVVSHANV----------LALFAATQRWFGF---NEddvwtLFHSYAfdfSVW 150
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 343 GTMMCLMYGATLILASP-IFNGKKALEAISRERG-TFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAI 420
Cdd:cd17643 151 EIWGALLHGGRLVVVPYeVARSPEDFARLLRDEGvTVLNQTPSAFYQLVEAADRDGRDPLALRYVIFGGEALEAAMLRPW 230
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 421 INKINMK--DLVVAYGTTENSP-VTFAHF-PEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLG 496
Cdd:cd17643 231 AGRFGLDrpQLVNMYGITETTVhVTFRPLdAADLPAAAASPIGRPLPGLRVYVLD-ADGRPVPPGVVGELYVSGAGVARG 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 497 YWGEPQKTEE-------AVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGgENIYPAELEDFFHTHPKVQEVqVVGV 568
Cdd:cd17643 310 YLGRPELTAErfvanpfGGPGSRMYRTGDLARRLPDGELEYLGRADEQVkIRG-FRIELGEIEAALATHPSVRDA-AVIV 387
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 569 KDDRMGEE-ICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 627
Cdd:cd17643 388 REDEPGDTrLVAYVVADDGAAADIAELRALLKELLPDYMVPARYVPLDALPLTVNGKLDR 447
|
|
| A_NRPS_SidN3_like |
cd05918 |
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ... |
280-636 |
6.24e-23 |
|
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family of siderophore-synthesizing NRPS includes the third adenylation domain of SidN from the endophytic fungus Neotyphodium lolii, ferrichrome siderophore synthetase, HC-toxin synthetase, and enniatin synthase. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341242 [Multi-domain] Cd Length: 481 Bit Score: 102.62 E-value: 6.24e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 280 HDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMilpnpL----YHCLGSVAGTMMCLMYGATLI 355
Cdd:cd05918 106 SDAAYVIFTSGSTGKPKGVVIEHRALSTSALAHGRALGLTSES----RV-----LqfasYTFDVSILEIFTTLAAGGCLC 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 356 LASpifngKKAL-----EAISRERGTFLYGTPTmFVDILNQPDFSSydISTMcggVIAGSPAPPELIRAIINKINmkdLV 430
Cdd:cd05918 177 IPS-----EEDRlndlaGFINRLRVTWAFLTPS-VARLLDPEDVPS--LRTL---VLGGEALTQSDVDTWADRVR---LI 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 431 VAYGTTENSPvtFAHFPEDTVEQKAESVGRIMPhteARI-----MNMEAgtLAKLNTPGELCIRGYCVMLGYWGEPQKTE 505
Cdd:cd05918 243 NAYGPAECTI--AATVSPVVPSTDPRNIGRPLG---ATCwvvdpDNHDR--LVPIGAVGELLIEGPILARGYLNDPEKTA 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 506 EA-VDQDKW------------YWTGDVATMNEQGFCKIVGRSKDMI-IRgGENIYPAELEDFFHTHPKVQEVQVVGV--- 568
Cdd:cd05918 316 AAfIEDPAWlkqegsgrgrrlYRTGDLVRYNPDGSLEYVGRKDTQVkIR-GQRVELGEIEHHLRQSLPGAKEVVVEVvkp 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 569 KDDRMGEEICACIRLKDGEETT-----------------VEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:cd05918 395 KDGSSSPQLVAFVVLDGSSSGSgdgdslflepsdefralVAELRSKLRQRLPSYMVPSVFLPLSHLPLTASGKIDRRALR 474
|
....*
gi 572872742 632 EQMER 636
Cdd:cd05918 475 ELAES 479
|
|
| A_NRPS_ProA |
cd17656 |
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ... |
114-630 |
9.30e-23 |
|
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains gramicidin S synthase 2 (also known as ATP-dependent proline adenylase or proline activase or ProA). ProA is a multifunctional enzyme involved in synthesis of the cyclic peptide antibiotic gramicidin S and able to activate and polymerize the amino acids proline, valine, ornithine and leucine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341311 [Multi-domain] Cd Length: 479 Bit Score: 101.78 E-value: 9.30e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 114 EALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLK 193
Cdd:cd17656 3 DAVAVVFENQKLTYRELNERSNQLARFLREKGVKKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYPEERRIYIML 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 194 KVGCKALVFPKQFKTQQYYNvlkqicpevenaqpgalKSQRLPDLTTVISVDAPLpgtllLDEVVAAgstrqhlDQLQYn 273
Cdd:cd17656 83 DSGVRVVLTQRHLKSKLSFN-----------------KSTILLEDPSISQEDTSN-----IDYINNS-------DDLLY- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 274 qqflschdpinIQFTSGTTGSPKGATLSHYNIVN-------NSNILGERLKLHEKTPEQlrmilpNPLYHCLGSVagtmm 346
Cdd:cd17656 133 -----------IIYTSGTTGKPKGVQLEHKNMVNllhfereKTNINFSDKVLQFATCSF------DVCYQEIFST----- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 347 cLMYGATLILASPIF--NGKKALEAISRERGTFLYgTPTMFVDILnqpdFSSYDIStmcggviagsPAPPELIRAII--- 421
Cdd:cd17656 191 -LLSGGTLYIIREETkrDVEQLFDLVKRHNIEVVF-LPVAFLKFI----FSEREFI----------NRFPTCVKHIItag 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 422 NKINMKDLVVA------------YGTTENSPVTFAHF-PEDTVeQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCI 488
Cdd:cd17656 255 EQLVITNEFKEmlhehnvhlhnhYGPSETHVVTTYTInPEAEI-PELPPIGKPISNTWIYILD-QEQQLQPQGIVGELYI 332
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 489 RGYCVMLGYWGEPQKTEEAVDQDKW------YWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQE 562
Cdd:cd17656 333 SGASVARGYLNRQELTAEKFFPDPFdpnermYRTGDLARYLPDGNIEFLGRADHQVKIRGYRIELGEIEAQLLNHPGVSE 412
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 572872742 563 VQVVGVKDDRMGEEICACIRLKdgEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 630
Cdd:cd17656 413 AVVLDKADDKGEKYLCAYFVME--QELNISQLREYLAKQLPEYMIPSFFVPLDQLPLTPNGKVDRKAL 478
|
|
| PRK09274 |
PRK09274 |
peptide synthase; Provisional |
103-586 |
1.66e-22 |
|
peptide synthase; Provisional
Pssm-ID: 236443 [Multi-domain] Cd Length: 552 Bit Score: 101.90 E-value: 1.66e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVVLH--------EDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGI 174
Cdd:PRK09274 12 LPRAAQERPDQLAVAVPGgrgadgklAYDELSFAELDARSDAIAHGLNAAGIGRGMRAVLMVTPSLEFFALTFALFKAGA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 175 ILVSVNPAyqameleyvlkkVGCKALvfpKQfktqqyynVLKQICPEVENAQPGALKSQRL-----PDLTTVISVDAPL- 248
Cdd:PRK09274 92 VPVLVDPG------------MGIKNL---KQ--------CLAEAQPDAFIGIPKAHLARRLfgwgkPSVRRLVTVGGRLl 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 249 PGTLLLDEVvaagstRQHLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHynivnnSNILGERLKLHEktpeqLRM 328
Cdd:PRK09274 149 WGGTTLATL------LRDGAAAPFPMADLAPDDMAAILFTSGSTGTPKGVVYTH------GMFEAQIEALRE-----DYG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 329 ILPN-------PLYHCLGSVAGtmmclmyGATLI----LASPIF-NGKKALEAISRERGTFLYGTPTMFVDIL-----NQ 391
Cdd:PRK09274 212 IEPGeidlptfPLFALFGPALG-------MTSVIpdmdPTRPATvDPAKLFAAIERYGVTNLFGSPALLERLGrygeaNG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 392 PDFSSydISTmcggVI-AGSPAPPELI---RAIINkiNMKDLVVAYGTTENSPVTF----AHFpEDTVEQKAES----VG 459
Cdd:PRK09274 285 IKLPS--LRR----VIsAGAPVPIAVIerfRAMLP--PDAEILTPYGATEALPISSiesrEIL-FATRAATDNGagicVG 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 460 RIMPHTEARIMNMEAGTLA------KLNTP--GELCIRGYCVMLGYWGEPQKTEEA----VDQDKWYWTGDVATMNEQG- 526
Cdd:PRK09274 356 RPVDGVEVRIIAISDAPIPewddalRLATGeiGEIVVAGPMVTRSYYNRPEATRLAkipdGQGDVWHRMGDLGYLDAQGr 435
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 572872742 527 --FCkivGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDrmGEEICA-CIRLKDG 586
Cdd:PRK09274 436 lwFC---GRKAHRVETAGGTLYTIPCERIFNTHPGVKRSALVGVGVP--GAQRPVlCVELEPG 493
|
|
| PRK12582 |
PRK12582 |
acyl-CoA synthetase; Provisional |
107-521 |
9.21e-22 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237144 [Multi-domain] Cd Length: 624 Bit Score: 99.74 E-value: 9.21e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 107 AQRVPEREALVvlhedvRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAM 186
Cdd:PRK12582 69 AQREPGHGQWR------KVTYGEAKRAVDALAQALLDLGLDPGRPVMILSGNSIEHALMTLAAMQAGVPAAPVSPAYSLM 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 187 ELEYVlkkvgckalvfpkqfKTQQYYNVLKqicPEVENAQPGAL--KSQRLPDLT--TVISVDAPLPG--TLLLDEVVAA 260
Cdd:PRK12582 143 SHDHA---------------KLKHLFDLVK---PRVVFAQSGAPfaRALAALDLLdvTVVHVTGPGEGiaSIAFADLAAT 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 261 GSTrqhlDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVnnSNILGerlklhektPEQLRMILPN-------- 332
Cdd:PRK12582 205 PPT----AAVAAAIAAITPDTVAKYLFTSGSTGMPKAVINTQRMMC--ANIAM---------QEQLRPREPDppppvsld 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 333 --PLYHCLGSVAGTMMCLMYGATLIlaspIFNGK----------KALEAISRergTFLYGTP---TMFVDILNQPD---- 393
Cdd:PRK12582 270 wmPWNHTMGGNANFNGLLWGGGTLY----IDDGKplpgmfeetiRNLREISP---TVYGNVPagyAMLAEAMEKDDalrr 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 394 --FSsyDISTMCGGviaGSPAPPELIRaiinkiNMKDLVVA-----------YGTTENSPVT-FAHFPedtveqkAESVG 459
Cdd:PRK12582 343 sfFK--NLRLMAYG---GATLSDDLYE------RMQALAVRttghripfytgYGATETAPTTtGTHWD-------TERVG 404
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572872742 460 RI---MPHTEARimnmeagtLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVAT 521
Cdd:PRK12582 405 LIglpLPGVELK--------LAPVGDKYEVRVKGPNVTPGYHKDPELTAAAFDEEGFYRLGDAAR 461
|
|
| A_NRPS_PpsD_like |
cd17650 |
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ... |
114-625 |
1.29e-21 |
|
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetase 1 (BacA) in Bacillus licheniformis, tyrocidine synthetase in Brevibacillus brevis, plipastatin synthase (PpsD, an important antifungal protein) in Bacillus subtilis and mannopeptimycin peptide synthetase (MppB) in Streptomyces hygroscopicus. Plipastatin has strong fungitoxic activity and is involved in inhibition of phospholipase A2 and biofilm formation. Bacitracin, a mixture of related cyclic peptides, is used as a polypeptide antibiotic while function of tyrocidine is thought to be regulation of sporulation. MppB is involved in biosynthetic pathway of mannopeptimycin, a novel class of mannosylated lipoglycopeptides. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341305 [Multi-domain] Cd Length: 447 Bit Score: 97.92 E-value: 1.29e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 114 EALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLK 193
Cdd:cd17650 2 DAIAVSDATRQLTYRELNERANQLARTLRGLGVAPGSVVGVCADRSLDAIVGLLAVLKAGGAYVPIDPDYPAERLQYMLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 194 KVGCKALVfpkqfktqqyynvlkqicpevenAQPGalksqrlpdlttvisvdaplpgtllldevvaagstrqhldqlqyn 273
Cdd:cd17650 82 DSGAKLLL-----------------------TQPE--------------------------------------------- 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 274 qqflschDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMilpnplyhclGSV-----AGTMM-C 347
Cdd:cd17650 94 -------DLAYVIYTSGTTGKPKGVMVEHRNVAHAAHAWRREYELDSFPVRLLQM----------ASFsfdvfAGDFArS 156
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 348 LMYGATLILASP--IFNGKKALEAISRERGTFLYGTPTMFVDIL-----NQPDFSSYDIsTMCGGVIAGSPAPPELIRAI 420
Cdd:cd17650 157 LLNGGTLVICPDevKLDPAALYDLILKSRITLMESTPALIRPVMayvyrNGLDLSAMRL-LIVGSDGCKAQDFKTLAARF 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 421 INKINmkdLVVAYGTTENSpVTFAHFPEDTVEQKAES---VGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGY 497
Cdd:cd17650 236 GQGMR---IINSYGVTEAT-IDSTYYEEGRDPLGDSAnvpIGRPLPNTAMYVLD-ERLQPQPVGVAGELYIGGAGVARGY 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 498 WGEPQKTEEAVDQDKW------YWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDD 571
Cdd:cd17650 311 LNRPELTAERFVENPFapgermYRTGDLARWRADGNVELLGRVDHQVKIRGFRIELGEIESQLARHPAIDEAVVAVREDK 390
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 572872742 572 RMGEEICACIRLKDGEETTveEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:cd17650 391 GGEARLCAYVVAAATLNTA--ELRAFLAKELPSYMIPSYYVQLDALPLTPNGKV 442
|
|
| FATP_chFAT1_like |
cd05937 |
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA ... |
287-633 |
1.48e-21 |
|
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA synthetase in fungi; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis. Members of this family are fungal FATPs, including FAT1 from Cochliobolus heterostrophus.
Pssm-ID: 341260 [Multi-domain] Cd Length: 468 Bit Score: 98.27 E-value: 1.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 287 FTSGTTGSPKGATLSHYNIVNNSNILGErlKLHEKTPeqLRMILPNPLYHCLGSVAGTMMCLMYGATLILaSPIFNGKKA 366
Cdd:cd05937 94 YTSGTTGLPKAAAISWRRTLVTSNLLSH--DLNLKNG--DRTYTCMPLYHGTAAFLGACNCLMSGGTLAL-SRKFSASQF 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 367 LEAISRERGTFLYGTPTMFVDILNQPDfSSYDISTMCGgVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHF 446
Cdd:cd05937 169 WKDVRDSGATIIQYVGELCRYLLSTPP-SPYDRDHKVR-VAWGNGLRPDIWERFRERFNVPEIGEFYAATEGVFALTNHN 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 447 PEDTVEQKAESVGRIM--------------PHTEARIMNMEAG--TLAKLNTPGELCIRGYCVML----GYWGEPQKTEE 506
Cdd:cd05937 247 VGDFGAGAIGHHGLIRrwkfenqvvlvkmdPETDDPIRDPKTGfcVRAPVGEPGEMLGRVPFKNReafqGYLHNEDATES 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 507 AVDQ------DKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVK----DDRMGee 576
Cdd:cd05937 327 KLVRdvfrkgDIYFRTGDLLRQDADGRWYFLDRLGDTFRWKSENVSTTEVADVLGAHPDIAEANVYGVKvpghDGRAG-- 404
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572872742 577 iCACIRLKDGEETTVEEIKA----FCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:cd05937 405 -CAAITLEESSAVPTEFTKSllasLARKNLPSYAVPLFLRLTEEVATTDNHKQQKGVLRDE 464
|
|
| PRK09192 |
PRK09192 |
fatty acyl-AMP ligase; |
125-632 |
2.75e-21 |
|
fatty acyl-AMP ligase;
Pssm-ID: 236403 [Multi-domain] Cd Length: 579 Bit Score: 98.15 E-value: 2.75e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 125 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGiiLVSVnpayqameleyvlkkvgckALVFPK 204
Cdd:PRK09192 50 LPYQTLRARAEAGARRLLALGLKPGDRVALIAETDGDFVEAFFACQYAG--LVPV-------------------PLPLPM 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 205 QFKTQQYYnvLKQICPEVENAQPGAL-KSQRLPDLTTVISVDAPLPGTL---LLDEVVAAGstrqhlDQLQYNQQflscH 280
Cdd:PRK09192 109 GFGGRESY--IAQLRGMLASAQPAAIiTPDELLPWVNEATHGNPLLHVLshaWFKALPEAD------VALPRPTP----D 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 281 DPINIQFTSGTTGSPKGATLSHYNIVNN-SNILGERLKLHEKTpeqlRMILPNPLYH------CLGSVAGTMMCLMYGAT 353
Cdd:PRK09192 177 DIAYLQYSSGSTRFPRGVIITHRALMANlRAISHDGLKVRPGD----RCVSWLPFYHdmglvgFLLTPVATQLSVDYLPT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 354 LILA-SPIfngkKALEAISRERGTFLYgTPTMFVDI----LNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKI---- 424
Cdd:PRK09192 253 RDFArRPL----QWLDLISRNRGTISY-SPPFGYELcarrVNSKDLAELDLSCWRVAGIGADMIRPDVLHQFAEAFapag 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 425 -NMKDLVVAYGTTENS-PVTFAhfPE------DTVE-------QKAESV-------------GRIMPHTEARIMNmEAGT 476
Cdd:PRK09192 328 fDDKAFMPSYGLAEATlAVSFS--PLgsgivvEEVDrdrleyqGKAVAPgaetrrvrtfvncGKALPGHEIEIRN-EAGM 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 477 LAKLNTPGELCIRGYCVMLGYWGEpQKTEEAVDQDKWYWTGDVATMNEqGFCKIVGRSKDMIIRGGENIYPAELEDFFHT 556
Cdd:PRK09192 405 PLPERVVGHICVRGPSLMSGYFRD-EESQDVLAADGWLDTGDLGYLLD-GYLYITGRAKDLIIINGRNIWPQDIEWIAEQ 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 557 HPKVQ--EVQVVGVKDDRmGEEICACIRLKDGEETTVEEIKAFCKGKI-SHFKIPKYIVFVTNY--PLTISGKIQKFKLR 631
Cdd:PRK09192 483 EPELRsgDAAAFSIAQEN-GEKIVLLVQCRISDEERRGQLIHALAALVrSEFGVEAAVELVPPHslPRTSSGKLSRAKAK 561
|
.
gi 572872742 632 E 632
Cdd:PRK09192 562 K 562
|
|
| A_NRPS_ApnA-like |
cd17644 |
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ... |
285-625 |
3.67e-21 |
|
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Planktothrix agardhii anabaenopeptin synthetase (ApnA A1), which is capable of activating two chemically distinct amino acids (Arg and Tyr). Structural studies show that the architecture of the active site forces Arg to adopt a Tyr-like conformation, thus explaining the bispecificity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341299 [Multi-domain] Cd Length: 465 Bit Score: 96.74 E-value: 3.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 285 IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhektPEQLRmILPNPLYHCLGSVAGTMMCLMYGATLIL--ASPIFN 362
Cdd:cd17644 111 VIYTSGSTGKPKGVMIEHQSLVNLSHGLIKEYGI----TSSDR-VLQFASIAFDVAAEEIYVTLLSGATLVLrpEEMRSS 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 363 GKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPA-PPELIR----AIINKINmkdLVVAYGTTE 437
Cdd:cd17644 186 LEDFVQYIQQWQLTVLSLPPAYWHLLVLELLLSTIDLPSSLRLVIVGGEAvQPELVRqwqkNVGNFIQ---LINVYGPTE 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 438 NS-PVTFAHFPEDTVEQKAE-SVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQD---- 511
Cdd:cd17644 263 ATiAATVCRLTQLTERNITSvPIGRPIANTQVYILD-ENLQPVPVGVPGELHIGGVGLARGYLNRPELTAEKFISHpfns 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 512 ----KWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGEnIYPAELEDFFHTHPKVQEVqVVGVKDDRMGEE-ICACIRLKD 585
Cdd:cd17644 342 seseRLYKTGDLARYLPDGNIEYLGRIDNQVkIRGFR-IELGEIEAVLSQHNDVKTA-VVIVREDQPGNKrLVAYIVPHY 419
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 572872742 586 GEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:cd17644 420 EESPSTVELRQFLKAKLPDYMIPSAFVVLEELPLTPNGKI 459
|
|
| PRK05851 |
PRK05851 |
long-chain-fatty acid--ACP ligase MbtM; |
266-635 |
4.61e-21 |
|
long-chain-fatty acid--ACP ligase MbtM;
Pssm-ID: 180289 [Multi-domain] Cd Length: 525 Bit Score: 97.14 E-value: 4.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 266 HLDQLQYNQQFLSCHD--------------------PINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQ 325
Cdd:PRK05851 118 HLERLRAVDSSVTVHDlataahtnrsasltppdsggPAVLQGTAGSTGTPRTAILSPGAVLSNLRGLNARVGLDAATDVG 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 326 LRMIlpnPLYHCLGsVAGTMMCLMYGATLILA-------SPIfngkKALEAISRERGTFLYGtPTMFVDILNQ--PDFSS 396
Cdd:PRK05851 198 CSWL---PLYHDMG-LAFLLTAALAGAPLWLApttafsaSPF----RWLSWLSDSRATLTAA-PNFAYNLIGKyaRRVSD 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 397 YDISTMCGGVIAGSPAPPELIRAIINKI-----NMKDLVVAYGTTENS-------PVTFAHF-----PEDTVEQKAESVG 459
Cdd:PRK05851 269 VDLGALRVALNGGEPVDCDGFERFATAMapfgfDAGAAAPSYGLAESTcavtvpvPGIGLRVdevttDDGSGARRHAVLG 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 460 RIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPqkteeAVDQDKWYWTGDVATMNEQGFCkIVGRSKDMII 539
Cdd:PRK05851 349 NPIPGMEVRISPGDGAAGVAGREIGEIEIRGASMMSGYLGQA-----PIDPDDWFPTGDLGYLVDGGLV-VCGRAKELIT 422
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 540 RGGENIYPAELEDFFHTHPKVQEVQVVGVKDD----RMGEEICACIRLKDgEETT----VEEIKAFCKgkishfKIPKYI 611
Cdd:PRK05851 423 VAGRNIFPTEIERVAAQVRGVREGAVVAVGTGegsaRPGLVIAAEFRGPD-EAGArsevVQRVASECG------VVPSDV 495
|
410 420
....*....|....*....|....*.
gi 572872742 612 VFVT--NYPLTISGKIQKFKLREQME 635
Cdd:PRK05851 496 VFVApgSLPRTSSGKLRRLAVKRSLE 521
|
|
| PRK08308 |
PRK08308 |
acyl-CoA synthetase; Validated |
280-632 |
1.02e-20 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236231 [Multi-domain] Cd Length: 414 Bit Score: 95.10 E-value: 1.02e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 280 HDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKlhekTPEQLRMILPNPLYHCLGSVAGTMMCLMYGAT-LILAS 358
Cdd:PRK08308 101 EEPSLLQYSSGTTGEPKLIRRSWTEIDREIEAYNEALN----CEQDETPIVACPVTHSYGLICGVLAALTRGSKpVIITN 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 359 PifNGKKALEAISRERGTFLYGTPTMFVDI--LNQPDFSSYDISTmcggviAGSPAPPELIRAIINKINMkdLVVAYGTT 436
Cdd:PRK08308 177 K--NPKFALNILRNTPQHILYAVPLMLHILgrLLPGTFQFHAVMT------SGTPLPEAWFYKLRERTTY--MMQQYGCS 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 437 ENSPVTFAHFPEDtveqkAESVGRIMPHteariMNMEAGTlaKLNTPGELCIRgycvmlgywgepQKTEEAVDQDKWYWT 516
Cdd:PRK08308 247 EAGCVSICPDMKS-----HLDLGNPLPH-----VSVSAGS--DENAPEEIVVK------------MGDKEIFTKDLGYKS 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 517 gdvatmnEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICAciRLKDGEETTVEEIKA 596
Cdd:PRK08308 303 -------ERGTLHFMGRMDDVINVSGLNVYPIEVEDVMLRLPGVQEAVVYRGKDPVAGERVKA--KVISHEEIDPVQLRE 373
|
330 340 350
....*....|....*....|....*....|....*.
gi 572872742 597 FCKGKISHFKIPKYIVFVTNYPLTISGKIQKfKLRE 632
Cdd:PRK08308 374 WCIQHLAPYQVPHEIESVTEIPKNANGKVSR-KLLE 408
|
|
| PRK07867 |
PRK07867 |
acyl-CoA synthetase; Validated |
287-633 |
1.46e-20 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236120 [Multi-domain] Cd Length: 529 Bit Score: 95.52 E-value: 1.46e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 287 FTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMilpnPLYHCLGSVAGTMMCLMYGATLILaSPIFNGKKA 366
Cdd:PRK07867 159 FTSGTSGDPKAVRCTHRKVASAGVMLAQRFGLGPDDVCYVSM----PLFHSNAVMAGWAVALAAGASIAL-RRKFSASGF 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 367 LEAISRERGTFL-Y-GTPTMFvdIL---NQPDFSSYDISTMcggviAGSPAPPELIRAIINKINMKdLVVAYGTTENSpV 441
Cdd:PRK07867 234 LPDVRRYGATYAnYvGKPLSY--VLatpERPDDADNPLRIV-----YGNEGAPGDIARFARRFGCV-VVDGFGSTEGG-V 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 442 TFAHFPeDTveqKAESVGRIMPHTEarIMNMEAGT---------LAKLNTP---GELC-IRGYCVMLGYWGEPQKTEEAV 508
Cdd:PRK07867 305 AITRTP-DT---PPGALGPLPPGVA--IVDPDTGTecppaedadGRLLNADeaiGELVnTAGPGGFEGYYNDPEADAERM 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 509 dQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEE 588
Cdd:PRK07867 379 -RGGVYWSGDLAYRDADGYAYFAGRLGDWMRVDGENLGTAPIERILLRYPDATEVAVYAVPDPVVGDQVMAALVLAPGAK 457
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 572872742 589 TTVEEIKAFCKGK--ISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK07867 458 FDPDAFAEFLAAQpdLGPKQWPSYVRVCAELPRTATFKVLKRQLSAE 504
|
|
| AMP-binding_C |
pfam13193 |
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to ... |
549-624 |
1.65e-20 |
|
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to pfam00501. It has a central beta sheet core that is flanked by alpha helices.
Pssm-ID: 463804 [Multi-domain] Cd Length: 76 Bit Score: 85.67 E-value: 1.65e-20
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572872742 549 ELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGK 624
Cdd:pfam13193 1 EVESALVSHPAVAEAAVVGVPDELKGEAPVAFVVLKPGVELLEEELVAHVREELGPYAVPKEVVFVDELPKTRSGK 76
|
|
| PRK08043 |
PRK08043 |
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase; |
285-535 |
3.89e-20 |
|
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
Pssm-ID: 181207 [Multi-domain] Cd Length: 718 Bit Score: 94.78 E-value: 3.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 285 IQFTSGTTGSPKGATLSHYNIVNNSnilgerlklhektpEQLRMI---LPN-------PLYHCLGSVAGTMMCLMYGATL 354
Cdd:PRK08043 370 ILFTSGSEGHPKGVVHSHKSLLANV--------------EQIKTIadfTPNdrfmsalPLFHSFGLTVGLFTPLLTGAEV 435
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 355 IL-ASPIfNGKKALEAISRERGTFLYGTPTMfvdILNQPDFSS-YDISTMcGGVIAGSPAPPELIRAI-INKINMKDLVv 431
Cdd:PRK08043 436 FLyPSPL-HYRIVPELVYDRNCTVLFGTSTF---LGNYARFANpYDFARL-RYVVAGAEKLQESTKQLwQDKFGLRILE- 509
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 432 AYGTTENSPVTFAHFPedtVEQKAESVGRIMPHTEARIMNMeagtlAKLNTPGELCIRGYCVMLGYW-----GE---PQ- 502
Cdd:PRK08043 510 GYGVTECAPVVSINVP---MAAKPGTVGRILPGMDARLLSV-----PGIEQGGRLQLKGPNIMNGYLrvekpGVlevPTa 581
|
250 260 270
....*....|....*....|....*....|...
gi 572872742 503 KTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSK 535
Cdd:PRK08043 582 ENARGEMERGWYDTGDIVRFDEQGFVQIQGRAK 614
|
|
| PRK06060 |
PRK06060 |
p-hydroxybenzoic acid--AMP ligase FadD22; |
125-633 |
6.24e-20 |
|
p-hydroxybenzoic acid--AMP ligase FadD22;
Pssm-ID: 180374 [Multi-domain] Cd Length: 705 Bit Score: 94.33 E-value: 6.24e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 125 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPayqamELEyvlkkvgckalvfpk 204
Cdd:PRK06060 31 VTHGQIHDGAARLGEVLRNRGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAFLANP-----ELH--------------- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 205 qfKTQQYYnvlkqicPEVENAQPGALKSQRLPDLTTVISVDAPLPgtlLLDEVVAAGSTrqhldqlqyNQQFLSCHDPIN 284
Cdd:PRK06060 91 --RDDHAL-------AARNTEPALVVTSDALRDRFQPSRVAEAAE---LMSEAARVAPG---------GYEPMGGDALAY 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 285 IQFTSGTTGSPKGATLSHYNIVNNSNILGER-LKLhekTPEQLRMILPNpLYHCLGSVAGTMMCLMYGATLILASPIFNG 363
Cdd:PRK06060 150 ATYTSGTTGPPKAAIHRHADPLTFVDAMCRKaLRL---TPEDTGLCSAR-MYFAYGLGNSVWFPLATGGSAVINSAPVTP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 364 KKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDiSTMCGgVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVtf 443
Cdd:PRK06060 226 EAAAILSARFGPSVLYGVPNFFARVIDSCSPDSFR-SLRCV-VSAGEALELGLAERLMEFFGGIPILDGIGSTEVGQT-- 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 444 ahFPEDTVEQ-KAESVGRIMPHTEARIMNMEaGTLAKLNTPGELCIRGYCVMLGYWGEPqktEEAVDQDKWYWTGDVATM 522
Cdd:PRK06060 302 --FVSNRVDEwRLGTLGRVLPPYEIRVVAPD-GTTAGPGVEGDLWVRGPAIAKGYWNRP---DSPVANEGWLDTRDRVCI 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 523 NEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGE---ETTVEEIKAFCK 599
Cdd:PRK06060 376 DSDGWVTYRCRADDTEVIGGVNVDPREVERLIIEDEAVAEAAVVAVRESTGASTLQAFLVATSGAtidGSVMRDLHRGLL 455
|
490 500 510
....*....|....*....|....*....|....
gi 572872742 600 GKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK06060 456 NRLSAFKVPHRFAVVDRLPRTPNGKLVRGALRKQ 489
|
|
| PRK09029 |
PRK09029 |
O-succinylbenzoic acid--CoA ligase; Provisional |
107-619 |
7.19e-20 |
|
O-succinylbenzoic acid--CoA ligase; Provisional
Pssm-ID: 236363 [Multi-domain] Cd Length: 458 Bit Score: 93.01 E-value: 7.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 107 AQRVPEREALVVLHEdvRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAM 186
Cdd:PRK09029 13 AQVRPQAIALRLNDE--VLTWQQLCARIDQLAAGFAQQGVVEGSGVALRGKNSPETLLAYLALLQCGARVLPLNPQLPQP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 187 ELEYVLKKVGCKALVFPKQFKTQQYYNVLKQicPEVENAQPGALKSQRLPDLTtvisvdaplpgtllldevvaagstrqh 266
Cdd:PRK09029 91 LLEELLPSLTLDFALVLEGENTFSALTSLHL--QLVEGAHAVAWQPQRLATMT--------------------------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 267 ldqlqynqqflschdpiniqFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEktpeQLRMILPNPLYHclgsVAGTMM 346
Cdd:PRK09029 142 --------------------LTSGSTGLPKAAVHTAQAHLASAEGVLSLMPFTA----QDSWLLSLPLFH----VSGQGI 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 347 C---LMYGATLILaspifngkkaleaisRERGTF---LYGT------PTMFVDILNQPdfsSYDIST---MCGGviagSP 411
Cdd:PRK09029 194 VwrwLYAGATLVV---------------RDKQPLeqaLAGCthaslvPTQLWRLLDNR---SEPLSLkavLLGG----AA 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 412 APPELIRAiinkinmkdlvvA----------YGTTEnspvtFAhfpeDTVEQK-AES---VGRIMPHTEARIMNmeagtl 477
Cdd:PRK09029 252 IPVELTEQ------------AeqqgircwcgYGLTE-----MA----STVCAKrADGlagVGSPLPGREVKLVD------ 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 478 aklntpGELCIRGYCVMLGYW--GEPQkteEAVDQDKWYWTGDVATMNeQGFCKIVGRSKDMIIRGGENIYPAELEDFFH 555
Cdd:PRK09029 305 ------GEIWLRGASLALGYWrqGQLV---PLVNDEGWFATRDRGEWQ-NGELTILGRLDNLFFSGGEGIQPEEIERVIN 374
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 572872742 556 THPKVQEVQVVGVKDDRMGEEICACIRLKDgeETTVEEIKAFCKGKISHFKIPkyivfVTNYPL 619
Cdd:PRK09029 375 QHPLVQQVFVVPVADAEFGQRPVAVVESDS--EAAVVNLAEWLQDKLARFQQP-----VAYYLL 431
|
|
| FATP_FACS |
cd05940 |
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ... |
122-633 |
3.03e-19 |
|
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. At least five copies of FATPs are identified in mammalian cells. This family also includes prokaryotic FATPs. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341263 [Multi-domain] Cd Length: 449 Bit Score: 90.88 E-value: 3.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 122 DVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALV 201
Cdd:cd05940 1 DEALTYAELDAMANRYARWLKSLGLKPGDVVALFMENRPEYVLLWLGLVKIGAVAALINYNLRGESLAHCLNVSSAKHLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 202 FpkqfktqqyynvlkqicpevenaqpgalksqrlpdlttvisvdaplpgtllldevvaagstrqhldqlqynqqflschD 281
Cdd:cd05940 81 V------------------------------------------------------------------------------D 82
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 282 PINIQFTSGTTGSPKGATLSHYNIVNNSNI---LGERLKlhektpeQLRMILPNPLYHCLGSVAGTMMCLMYGATLILAS 358
Cdd:cd05940 83 AALYIYTSGTTGLPKAAIISHRRAWRGGAFfagSGGALP-------SDVLYTCLPLYHSTALIVGWSACLASGATLVIRK 155
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 359 PiFNGKKALEAISRERGtflygtpTMFVDI-------LNQP---DFSSYDISTMCGGVIAgspapPELIRAIINKINMKD 428
Cdd:cd05940 156 K-FSASNFWDDIRKYQA-------TIFQYIgelcrylLNQPpkpTERKHKVRMIFGNGLR-----PDIWEEFKERFGVPR 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 429 LVVAYGTTENSpVTFAHFPedtveQKAESVGRIMPHTE----ARIMNMEAGTLAKLNTPGELCIR------GYCV----- 493
Cdd:cd05940 223 IAEFYAATEGN-SGFINFF-----GKPGAIGRNPSLLRkvapLALVKYDLESGEPIRDAEGRCIKvprgepGLLIsrinp 296
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 494 ---MLGYWGePQKTEEAV------DQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQ 564
Cdd:cd05940 297 lepFDGYTD-PAATEKKIlrdvfkKGDAWFNTGDLMRLDGEGFWYFVDRLGDTFRWKGENVSTTEVAAVLGAFPGVEEAN 375
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 572872742 565 VVGVK----DDRMGeeiCACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:cd05940 376 VYGVQvpgtDGRAG---MAAIVLQPNEEFDLSALAAHLEKNLPGYARPLFLRLQPEMEITGTFKQQKVDLRNE 445
|
|
| PRK08180 |
PRK08180 |
feruloyl-CoA synthase; Reviewed |
98-518 |
3.09e-19 |
|
feruloyl-CoA synthase; Reviewed
Pssm-ID: 236175 [Multi-domain] Cd Length: 614 Bit Score: 91.86 E-value: 3.09e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 98 TVGQCLETTAQRVPEREALV---VLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGI 174
Cdd:PRK08180 40 RLTDRLVHWAQEAPDRVFLAergADGGWRRLTYAEALERVRAIAQALLDRGLSAERPLMILSGNSIEHALLALAAMYAGV 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 175 ILVSVNPAYQAM-----ELEYVLKKVGcKALVFpkqfktqqyynvlkqicpeVENAQP--GALKSQRLPDlTTVISVDAP 247
Cdd:PRK08180 120 PYAPVSPAYSLVsqdfgKLRHVLELLT-PGLVF-------------------ADDGAAfaRALAAVVPAD-VEVVAVRGA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 248 LPG--TLLLDEVVAAGSTRQhLDQLqynqqflscHDPIN------IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLH 319
Cdd:PRK08180 179 VPGraATPFAALLATPPTAA-VDAA---------HAAVGpdtiakFLFTSGSTGLPKAVINTHRMLCANQQMLAQTFPFL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 320 EKTPEQLRMILP-NplyHCLGSVAGTMMCLMYGATLIlaspIFNGK----------KALEAISrerGTFLYGTPT---MF 385
Cdd:PRK08180 249 AEEPPVLVDWLPwN---HTFGGNHNLGIVLYNGGTLY----IDDGKptpggfdetlRNLREIS---PTVYFNVPKgweML 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 386 VDILNQPD------FSSYDIsTMCGGviAGSPAP-----PEL-IRAIINKINMkdlVVAYGTTENSPV-TFAHFPEDtve 452
Cdd:PRK08180 319 VPALERDAalrrrfFSRLKL-LFYAG--AALSQDvwdrlDRVaEATCGERIRM---MTGLGMTETAPSaTFTTGPLS--- 389
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572872742 453 qKAESVGRIMPHTEARimnmeagtLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGD 518
Cdd:PRK08180 390 -RAGNIGLPAPGCEVK--------LVPVGGKLEVRVKGPNVTPGYWRAPELTAEAFDEEGYYRSGD 446
|
|
| PTZ00216 |
PTZ00216 |
acyl-CoA synthetase; Provisional |
118-535 |
6.78e-19 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 240316 [Multi-domain] Cd Length: 700 Bit Score: 90.81 E-value: 6.78e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 118 VLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWvlmqLATAQA----GIILVSV--NPAYQAmeLEYV 191
Cdd:PTZ00216 115 HFNETRYITYAELWERIVNFGRGLAELGLTKGSNVAIYEETRWEW----LASIYGiwsqSMVAATVyaNLGEDA--LAYA 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 192 LKKVGCKALVFPKQfktqqyyNVLKQIcpevenaqpGALKSQRLPDlTTVISVDApLPGTLLLD--------EVVAAGST 263
Cdd:PTZ00216 189 LRETECKAIVCNGK-------NVPNLL---------RLMKSGGMPN-TTIIYLDS-LPASVDTEgcrlvawtDVVAKGHS 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 264 RQhlDQLQYNQQfLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERL-KLHEKTPEQLRMILPNPLYHCLgSVA 342
Cdd:PTZ00216 251 AG--SHHPLNIP-ENNDDLALIMYTSGTTGDPKGVMHTHGSLTAGILALEDRLnDLIGPPEEDETYCSYLPLAHIM-EFG 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 343 GTMMCLMYGATLILASP---------------------------IFNG-KKALEAISRERGTF-------LY-------- 379
Cdd:PTZ00216 327 VTNIFLARGALIGFGSPrtltdtfarphgdltefrpvfligvprIFDTiKKAVEAKLPPVGSLkrrvfdhAYqsrlralk 406
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 380 -GTPTMFvdiLNQPDFSSY------DISTMCGGVIAGSPAPPELIRAIINKInmkdlVVAYGTTENSPVTFAHFPEDTve 452
Cdd:PTZ00216 407 eGKDTPY---WNEKVFSAPravlggRVRAMLSGGGPLSAATQEFVNVVFGMV-----IQGWGLTETVCCGGIQRTGDL-- 476
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 453 qKAESVGRIMPHTEARIMNMEAgtLAKLNTP---GELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCK 529
Cdd:PTZ00216 477 -EPNAVGQLLKGVEMKLLDTEE--YKHTDTPeprGEILLRGPFLFKGYYKQEELTREVLDEDGWFHTGDVGSIAANGTLR 553
|
....*.
gi 572872742 530 IVGRSK 535
Cdd:PTZ00216 554 IIGRVK 559
|
|
| hsFATP2a_ACSVL_like |
cd05938 |
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar ... |
121-588 |
1.63e-18 |
|
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins; Fatty acid transport proteins (FATP) of this family transport long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes hsFATP2, hsFATP5, and hsFATP6, and similar proteins. Each FATP has unique patterns of tissue distribution. These FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. The hsFATP proteins exist in two splice variants; the b variant, lacking exon 3, has no acyl-CoA synthetase activity. FATPs are key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341261 [Multi-domain] Cd Length: 537 Bit Score: 89.27 E-value: 1.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 121 EDVRLTFAQLKEEVDKAASGLLS-IGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKA 199
Cdd:cd05938 2 EGETYTYRDVDRRSNQAARALLAhAGLRPGDTVALLLGNEPAFLWIWLGLAKLGCPVAFLNTNIRSKSLLHCFRCCGAKV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 200 LVFPKQFKtqqyyNVLKQICPevenaqpgALKSQRLPDLttVISVDAPLPGTL-LLDEVVAA------GSTRQHLdqlqy 272
Cdd:cd05938 82 LVVAPELQ-----EAVEEVLP--------ALRADGVSVW--YLSHTSNTEGVIsLLDKVDAAsdepvpASLRAHV----- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 273 nqqflSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlrMILPNPLYHCLGSVAGTMMCLMYGA 352
Cdd:cd05938 142 -----TIKSPALYIYTSGTTGLPKAARISHLRVLQCSGFLSLCGVTADDV-----IYITLPLYHSSGFLLGIGGCIELGA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 353 TLILAsPIFNGKKALEAISRERGT-FLYGTPTMFVdILNQPDFSSYDISTMcgGVIAGSPAPPELIRAIINKINMKDLVV 431
Cdd:cd05938 212 TCVLK-PKFSASQFWDDCRKHNVTvIQYIGELLRY-LCNQPQSPNDRDHKV--RLAIGNGLRADVWREFLRRFGPIRIRE 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 432 AYGTTENSpVTFAHFPEdtveqKAESVGRimphtearimnmeAGTLAKLNTPGELcIR-------------GYCV----- 493
Cdd:cd05938 288 FYGSTEGN-IGFFNYTG-----KIGAVGR-------------VSYLYKLLFPFEL-IKfdvekeepvrdaqGFCIpvakg 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 494 --------------MLGYWGEPQKTEEA----VDQ--DKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDF 553
Cdd:cd05938 348 epgllvakitqqspFLGYAGDKEQTEKKllrdVFKkgDVYFNTGDLLVQDQQNFLYFHDRVGDTFRWKGENVATTEVADV 427
|
490 500 510
....*....|....*....|....*....|....*....
gi 572872742 554 FHTHPKVQEVQVVGVK----DDRMGeeiCACIRLKDGEE 588
Cdd:cd05938 428 LGLLDFLQEVNVYGVTvpghEGRIG---MAAVKLKPGHE 463
|
|
| PRK08279 |
PRK08279 |
long-chain-acyl-CoA synthetase; Validated |
98-633 |
2.62e-18 |
|
long-chain-acyl-CoA synthetase; Validated
Pssm-ID: 236217 [Multi-domain] Cd Length: 600 Bit Score: 88.78 E-value: 2.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 98 TVGQCLETTAQRVPEREALvvLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILV 177
Cdd:PRK08279 38 SLGDVFEEAAARHPDRPAL--LFEDQSISYAELNARANRYAHWAAARGVGKGDVVALLMENRPEYLAAWLGLAKLGAVVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 178 SVNpaYQAME--LEYVLKKVGCKALVfpkqfktqqyynVLKQICPEVENAQPGALKSQRLPDLTTVISVDaplpgTLLLD 255
Cdd:PRK08279 116 LLN--TQQRGavLAHSLNLVDAKHLI------------VGEELVEAFEEARADLARPPRLWVAGGDTLDD-----PEGYE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 256 EVVAAGSTRQHLDQLQYNQQFLSchDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQlRMILPNPLY 335
Cdd:PRK08279 177 DLAAAAAGAPTTNPASRSGVTAK--DTAFYIYTSGTTGLPKAAVMSHMRWLKAMGGFGGLLRL---TPDD-VLYCCLPLY 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 336 H------CLGSVagtmmcLMYGATLILAsPIFNGKKALEAISRERGtflygtpTMFVDI-------LNQPDfSSYD---- 398
Cdd:PRK08279 251 HntggtvAWSSV------LAAGATLALR-RKFSASRFWDDVRRYRA-------TAFQYIgelcrylLNQPP-KPTDrdhr 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 399 ISTMCGgviAGspAPPELIRAIINKINMKDLVVAYGTTEnSPVTFAHFpedtvEQKAESVGRI-----MPH--------T 465
Cdd:PRK08279 316 LRLMIG---NG--LRPDIWDEFQQRFGIPRILEFYAASE-GNVGFINV-----FNFDGTVGRVplwlaHPYaivkydvdT 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 466 EARIMNmEAG--TLAKLNTPGELcirgycvmLG-------YWG--EPQKTEEAV------DQDKWYWTGDVATMNEQGFC 528
Cdd:PRK08279 385 GEPVRD-ADGrcIKVKPGEVGLL--------IGritdrgpFDGytDPEASEKKIlrdvfkKGDAWFNTGDLMRDDGFGHA 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 529 KIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVK----DDRMGeeiCACIRLKDGEETTVEEIKAFCKGKISH 604
Cdd:PRK08279 456 QFVDRLGDTFRWKGENVATTEVENALSGFPGVEEAVVYGVEvpgtDGRAG---MAAIVLADGAEFDLAALAAHLYERLPA 532
|
570 580
....*....|....*....|....*....
gi 572872742 605 FKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK08279 533 YAVPLFVRLVPELETTGTFKYRKVDLRKE 561
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
96-627 |
4.89e-18 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 89.06 E-value: 4.89e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 96 SKTVGQCLETTAQRVPEREALVVLHEdvRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGII 175
Cdd:PRK12467 1573 ARLVHQLIEDQAAATPEAVALVFGEQ--ELTYGELNRRANRLAHRLIALGVGPEVLVGIAVERSLEMVVGLLAILKAGGA 1650
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 176 LVSVNPAYQAMELEYVLKKVGCKALVfpkqfkTQqyynvlKQICPevenaqpgalksqRLPdlttvisvdaplpgtllld 255
Cdd:PRK12467 1651 YVPLDPEYPRERLAYMIEDSGIELLL------TQ------SHLQA-------------RLP------------------- 1686
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 256 evVAAGSTRQHLDQlqyNQQFLSCHDPINIQ------------FTSGTTGSPKGATLSHYNIVNNSNILGERLKLH---- 319
Cdd:PRK12467 1687 --LPDGLRSLVLDQ---EDDWLEGYSDSNPAvnlapqnlayviYTSGSTGRPKGAGNRHGALVNRLCATQEAYQLSaadv 1761
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 320 --EKTPeqlrmilpnplYHCLGSVAGTMMCLMYGATLILASPIF--NGKKALEAISRERGTFLYGTPTMFVDILNQPDFS 395
Cdd:PRK12467 1762 vlQFTS-----------FAFDVSVWELFWPLINGARLVIAPPGAhrDPEQLIQLIERQQVTTLHFVPSMLQQLLQMDEQV 1830
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 396 SYDIS---TMCGgviaGSPAPPELIRAIINKINMKDLVVAYGTTENSpVTFAHFP---EDTVEQKAESVGRIMPHTEARI 469
Cdd:PRK12467 1831 EHPLSlrrVVCG----GEALEVEALRPWLERLPDTGLFNLYGPTETA-VDVTHWTcrrKDLEGRDSVPIGQPIANLSTYI 1905
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 470 MNMEAgTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQD-------KWYWTGDVATMNEQGFCKIVGRSKDMI-IRG 541
Cdd:PRK12467 1906 LDASL-NPVPIGVAGELYLGGVGLARGYLNRPALTAERFVADpfgtvgsRLYRTGDLARYRADGVIEYLGRIDHQVkIRG 1984
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 542 GEnIYPAELEDFFHTHPKVQEVQVVgVKDDRMGEEICACIRLKDGE--------ETTVEEIKAFCKGKISHFKIPKYIVF 613
Cdd:PRK12467 1985 FR-IELGEIEARLREQGGVREAVVI-AQDGANGKQLVAYVVPTDPGlvdddeaqVALRAILKNHLKASLPEYMVPAHLVF 2062
|
570
....*....|....
gi 572872742 614 VTNYPLTISGKIQK 627
Cdd:PRK12467 2063 LARMPLTPNGKLDR 2076
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
103-632 |
9.68e-18 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 88.30 E-value: 9.68e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPA 182
Cdd:PRK05691 1137 LNEQARQTPERIALV--WDGGSLDYAELHAQANRLAHYLRDKGVGPDVCVAIAAERSPQLLVGLLAILKAGGAYVPLDPD 1214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 YQAMELEYVLKKVGCKALVfpkqfkTQqyynvlkqicpeveNAQPGALKSqrlPDLTTVISVDaplpgTLLLDE-VVAAG 261
Cdd:PRK05691 1215 YPAERLAYMLADSGVELLL------TQ--------------SHLLERLPQ---AEGVSAIALD-----SLHLDSwPSQAP 1266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 262 STRQHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHynivnnsNILGERLK-------------LHEKTPEQLRM 328
Cdd:PRK05691 1267 GLHLHGDNLAY------------VIYTSGSTGQPKGVGNTH-------AALAERLQwmqatyalddsdvLMQKAPISFDV 1327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 329 ilpnplyhclgSVAGTMMCLMYGATLILASPifnGK-----KALEAISRERGTFLYGTPTMFVDILNQPDfssydiSTMC 403
Cdd:PRK05691 1328 -----------SVWECFWPLITGCRLVLAGP---GEhrdpqRIAELVQQYGVTTLHFVPPLLQLFIDEPL------AAAC 1387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 404 GG---VIAGSPA-PPELIRAIINKINMKDLVVAYGTTENS-PVTFAHFPEDTVEQkaESVGRIMPHTEARIMNMEAgTLA 478
Cdd:PRK05691 1388 TSlrrLFSGGEAlPAELRNRVLQRLPQVQLHNRYGPTETAiNVTHWQCQAEDGER--SPIGRPLGNVLCRVLDAEL-NLL 1464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 479 KLNTPGELCIRGYCVMLGYWGEPQKTEE-------AVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELE 551
Cdd:PRK05691 1465 PPGVAGELCIGGAGLARGYLGRPALTAErfvpdplGEDGARLYRTGDRARWNADGALEYLGRLDQQVKLRGFRVEPEEIQ 1544
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 552 DFFHTHPKVQEVQVVgVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 631
Cdd:PRK05691 1545 ARLLAQPGVAQAAVL-VREGAAGAQLVGYYTGEAGQEAEAERLKAALAAELPEYMVPAQLIRLDQMPLGPSGKLDRRALP 1623
|
.
gi 572872742 632 E 632
Cdd:PRK05691 1624 E 1624
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
98-635 |
4.82e-17 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 85.99 E-value: 4.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 98 TVGQCLETTAQRVPEREALVVLHED----VRLTFAQLKEEVDKAASGLLSIGLcKGDRLGMWGPNSYAWVLMQLATAQAG 173
Cdd:PRK05691 10 TLVQALQRRAAQTPDRLALRFLADDpgegVVLSYRDLDLRARTIAAALQARAS-FGDRAVLLFPSGPDYVAAFFGCLYAG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 174 IILVsvnPAYqameleyvlkkvgckalvfPKQFKTQQYYNVLKQIcpeVENAQPgalksqRLpdLTTVISVDAPLPGtll 253
Cdd:PRK05691 89 VIAV---PAY-------------------PPESARRHHQERLLSI---IADAEP------RL--LLTVADLRDSLLQ--- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 254 LDEVVAAGSTRQ-HLDQLQ------YNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQL 326
Cdd:PRK05691 133 MEELAAANAPELlCVDTLDpalaeaWQEPALQPDDIAFLQYTSGSTALPKGVQVSHGNLVANEQLIRHGFGIDLNPDDVI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 327 RMILPnpLYHCLGSVAGTMMCLMYGATLILASP-IFNGK--KALEAISRERGTflygtptmfvdILNQPDF--------- 394
Cdd:PRK05691 213 VSWLP--LYHDMGLIGGLLQPIFSGVPCVLMSPaYFLERplRWLEAISEYGGT-----------ISGGPDFayrlcserv 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 395 -----SSYDIStmcGGVIAGSPAPP---ELIRAIINKI-----NMKDLVVAYGTTENS---------------PVTFAHF 446
Cdd:PRK05691 280 sesalERLDLS---RWRVAYSGSEPirqDSLERFAEKFaacgfDPDSFFASYGLAEATlfvsggrrgqgipalELDAEAL 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 447 PEDTVEQKAESV----GRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEA-VDQD--KWYWTGDV 519
Cdd:PRK05691 357 ARNRAEPGTGSVlmscGRSQPGHAVLIVDPQSLEVLGDNRVGEIWASGPSIAHGYWRNPEASAKTfVEHDgrTWLRTGDL 436
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 520 ATMNEqGFCKIVGRSKDMIIRGGENIYPAELEDFFHthpkvQEVQVV--------GVKDDrmGEE---ICACIRLKDGEE 588
Cdd:PRK05691 437 GFLRD-GELFVTGRLKDMLIVRGHNLYPQDIEKTVE-----REVEVVrkgrvaafAVNHQ--GEEgigIAAEISRSVQKI 508
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 572872742 589 TTVEE-IKAFCKGKISHFKIPKYIVFVTN---YPLTISGKIQKFKLREQME 635
Cdd:PRK05691 509 LPPQAlIKSIRQAVAEACQEAPSVVLLLNpgaLPKTSSGKLQRSACRLRLA 559
|
|
| entF |
PRK10252 |
enterobactin non-ribosomal peptide synthetase EntF; |
98-625 |
1.04e-16 |
|
enterobactin non-ribosomal peptide synthetase EntF;
Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 84.33 E-value: 1.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 98 TVGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILV 177
Cdd:PRK10252 459 TLSALVAQQAAKTPDAPALA--DARYQFSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWL 536
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 178 SVNPAYQAMELEYVLkkvgckalvfpkqfktqqyynvlkqicpevENAQPGALKSQ-----RLPDL--TTVISVDAPLPg 250
Cdd:PRK10252 537 PLDTGYPDDRLKMML------------------------------EDARPSLLITTadqlpRFADVpdLTSLCYNAPLA- 585
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 251 tllldevvAAGSTRQHLDQlqynqqflsCHDPINIQFTSGTTGSPKGATLSHYNIVN------NSNILGERLKLHEKTPE 324
Cdd:PRK10252 586 --------PQGAAPLQLSQ---------PHHTAYIIFTSGSTGRPKGVMVGQTAIVNrllwmqNHYPLTADDVVLQKTPC 648
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 325 QLRMilpnplyhclgSVAGTMMCLMYGATLILASPifNGKK---ALEA-ISRERGTFLYGTPTMFVDILNQPDFSSYDIS 400
Cdd:PRK10252 649 SFDV-----------SVWEFFWPFIAGAKLVMAEP--EAHRdplAMQQfFAEYGVTTTHFVPSMLAAFVASLTPEGARQS 715
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 401 TM------CggviAGSPAPPELIRAIINKINMKdLVVAYGTTENS-PVT-FAHFPEDTVEQKAESV--GRIMPHTEARIM 470
Cdd:PRK10252 716 CAslrqvfC----SGEALPADLCREWQQLTGAP-LHNLYGPTEAAvDVSwYPAFGEELAAVRGSSVpiGYPVWNTGLRIL 790
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 471 NmeagtlAKLN-----TPGELCIRGYCVMLGYWGEPQKTEE------AVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI- 538
Cdd:PRK10252 791 D------ARMRpvppgVAGDLYLTGIQLAQGYLGRPDLTASrfiadpFAPGERMYRTGDVARWLDDGAVEYLGRSDDQLk 864
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 539 IRgGENIYPAELEDFFHTHPKVQEV----QVVGVKDDRMGEE--ICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIV 612
Cdd:PRK10252 865 IR-GQRIELGEIDRAMQALPDVEQAvthaCVINQAAATGGDArqLVGYLVSQSGLPLDTSALQAQLRERLPPHMVPVVLL 943
|
570
....*....|...
gi 572872742 613 FVTNYPLTISGKI 625
Cdd:PRK10252 944 QLDQLPLSANGKL 956
|
|
| FCS |
cd05921 |
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ... |
124-520 |
1.32e-16 |
|
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl acid degradation pathway and enables some proteobacteria to grow on media containing feruloyl acid as the sole carbon source. It catalyzes the transfer of CoA to the carboxyl group of ferulic acid, which then forms feruloyl-CoA in the presence of ATP and Mg2. The resulting feruloyl-CoA is further degraded to vanillin and acetyl-CoA. Feruloyl-CoA synthetase (FCS) is a subfamily of the adenylate-forming enzymes superfamily.
Pssm-ID: 341245 [Multi-domain] Cd Length: 561 Bit Score: 83.25 E-value: 1.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 124 RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAM-----ELEYVLKKVGcK 198
Cdd:cd05921 25 RVTYAEALRQVRAIAQGLLDLGLSAERPLLILSGNSIEHALMALAAMYAGVPAAPVSPAYSLMsqdlaKLKHLFELLK-P 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 199 ALVFpkqfktqqyynvlkqicpeVENAQP--GALKSQRLPDlTTVISVDAPLPG--TLLLDEVVAA---GSTRQHLDQLQ 271
Cdd:cd05921 104 GLVF-------------------AQDAAPfaRALAAIFPLG-TPLVVSRNAVAGrgAISFAELAATpptAAVDAAFAAVG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 272 YNQ--QFLschdpiniqFTSGTTGSPKGATLSHYNIVnnSNILGERLKLHEKTPEQLRMILPNPLYHCLGSVAGTMMCLM 349
Cdd:cd05921 164 PDTvaKFL---------FTSGSTGLPKAVINTQRMLC--ANQAMLEQTYPFFGEEPPVLVDWLPWNHTFGGNHNFNLVLY 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 350 YGATLIlaspIFNGKKALEAIS------RERGTFLYGT-P---TMFVDILNQPD------FSsyDISTMcggVIAGSPAP 413
Cdd:cd05921 233 NGGTLY----IDDGKPMPGGFEetlrnlREISPTVYFNvPagwEMLVAALEKDEalrrrfFK--RLKLM---FYAGAGLS 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 414 PELIRAiINKINMKD------LVVAYGTTENSPV-TFAHFPEDtveqKAESVGRIMPHTEARimnmeagtLAKLNTPGEL 486
Cdd:cd05921 304 QDVWDR-LQALAVATvgeripMMAGLGATETAPTaTFTHWPTE----RSGLIGLPAPGTELK--------LVPSGGKYEV 370
|
410 420 430
....*....|....*....|....*....|....
gi 572872742 487 CIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVA 520
Cdd:cd05921 371 RVKGPNVTPGYWRQPELTAQAFDEEGFYCLGDAA 404
|
|
| A_NRPS_acs4 |
cd17654 |
acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal ... |
206-630 |
1.82e-16 |
|
acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains acyl-CoA synthethase family member 4, also known as 2-aminoadipic 6-semialdehyde dehydrogenase or aminoadipate-semialdehyde dehydrogenase, most of which are uncharacterized. Acyl-CoA synthetase catalyzes the initial reaction in fatty acid metabolism, by forming a thioester with CoA. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341309 [Multi-domain] Cd Length: 449 Bit Score: 82.13 E-value: 1.82e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 206 FKTQQYYNVLKQICPEVENAQPgaLKSQRLPDLTTVI-------SVDAPLPGTLLLDEVVAAGSTRqHLDQLQYN----Q 274
Cdd:cd17654 24 EKISNLSNFLRKKFQTEERAIG--LRCDRGTESPVAIlailflgAAYAPIDPASPEQRSLTVMKKC-HVSYLLQNkeldN 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 275 QFLSCHDP------------INIQFTSGTTGSPKGATLSHYNIVNnsNILGERLKLhEKTPEQLRmILPNPLyHCLGSVA 342
Cdd:cd17654 101 APLSFTPEhrhfnirtdeclAYVIHTSGTTGTPKIVAVPHKCILP--NIQHFRSLF-NITSEDIL-FLTSPL-TFDPSVV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 343 GTMMCLMYGATLI---LASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQ--PDFSSYDISTMCGGVIAGSPAPPELI 417
Cdd:cd17654 176 EIFLSLSSGATLLivpTSVKVLPSKLADILFKRHRITVLQATPTLFRRFGSQsiKSTVLSATSSLRVLALGGEPFPSLVI 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 418 -RAIINKINMKDLVVAYGTTENSpvTFAHFPEDTVEQKAESVGrimphTEARIMNMEAGTLAKLNTPGELCIRGY---CV 493
Cdd:cd17654 256 lSSWRGKGNRTRIFNIYGITEVS--CWALAYKVPEEDSPVQLG-----SPLLGTVIEVRDQNGSEGTGQVFLGGLnrvCI 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 494 MLGYWGEPQKTeeavdqdkWYWTGDVATMnEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRm 573
Cdd:cd17654 329 LDDEVTVPKGT--------MRATGDFVTV-KDGELFFLGRKDSQIKRRGKRINLDLIQQVIESCLGVESCAVTLSDQQR- 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 572872742 574 geeICACIRlkdGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 630
Cdd:cd17654 399 ---LIAFIV---GESSSSRIHKELQLTLLSSHAIPDTFVQIDKLPLTSHGKVDKSEL 449
|
|
| PRK03584 |
PRK03584 |
acetoacetate--CoA ligase; |
108-626 |
1.91e-16 |
|
acetoacetate--CoA ligase;
Pssm-ID: 235134 [Multi-domain] Cd Length: 655 Bit Score: 82.92 E-value: 1.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 108 QRVPEREALVVLHED---VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQ 184
Cdd:PRK03584 95 HRRDDRPAIIFRGEDgprRELSWAELRRQVAALAAALRALGVGPGDRVAAYLPNIPETVVAMLATASLGAIWSSCSPDFG 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 185 AmelEYVLKKVGckalvfpkqfktqqyynvlkQICPEVENAQPG---------------ALKSQrLPDLTTVISVD---- 245
Cdd:PRK03584 175 V---QGVLDRFG--------------------QIEPKVLIAVDGyryggkafdrrakvaELRAA-LPSLEHVVVVPylgp 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 246 ----APLPGTLLLDEVVAAGSTrqhlDQLQYNQqfLSCHDPINIQFTSGTTGSPKGATLSHynivnnSNILGERLKLHek 321
Cdd:PRK03584 231 aaaaAALPGALLWEDFLAPAEA----AELEFEP--VPFDHPLWILYSSGTTGLPKCIVHGH------GGILLEHLKEL-- 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 322 tpeQLrmilpnplyHC-LG--------SVAGTMM------CLMYGATLIL--ASPIFNGKKAL-EAISRERGTFLyGTPT 383
Cdd:PRK03584 297 ---GL---------HCdLGpgdrffwyTTCGWMMwnwlvsGLLVGATLVLydGSPFYPDPNVLwDLAAEEGVTVF-GTSA 363
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 384 MFVDILNQPDFS---SYDISTMCGGVIAGSPAPPELIRAIINKINmKDLVVAY---GT---------TENSPVTfahfpe 448
Cdd:PRK03584 364 KYLDACEKAGLVpgeTHDLSALRTIGSTGSPLPPEGFDWVYEHVK-ADVWLASisgGTdicscfvggNPLLPVY------ 436
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 449 dtveqkaesVGRIMphteARIMNM------EAGtlaklnTP-----GEL-CIRGYCVM-LGYWGEP--QKTEEAvdqdkw 513
Cdd:PRK03584 437 ---------RGEIQ----CRGLGMaveawdEDG------RPvvgevGELvCTKPFPSMpLGFWNDPdgSRYRDA------ 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 514 YWT--------GDVATMNEQGFCKIVGRSKDMIIRGGENIYPAEL----EDFfhthPKVQEVQVVGVKDDRMGEEICACI 581
Cdd:PRK03584 492 YFDtfpgvwrhGDWIEITEHGGVVIYGRSDATLNRGGVRIGTAEIyrqvEAL----PEVLDSLVIGQEWPDGDVRMPLFV 567
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|
gi 572872742 582 RLKDGEETT---VEEIKAFCKGKIS--HfkIPKYIVFVTNYPLTISGKIQ 626
Cdd:PRK03584 568 VLAEGVTLDdalRARIRTTIRTNLSprH--VPDKIIAVPDIPRTLSGKKV 615
|
|
| PLN02736 |
PLN02736 |
long-chain acyl-CoA synthetase |
125-554 |
2.42e-16 |
|
long-chain acyl-CoA synthetase
Pssm-ID: 178337 [Multi-domain] Cd Length: 651 Bit Score: 82.84 E-value: 2.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 125 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGiiLVSVnPAYQAM---ELEYVLKKVGCKALv 201
Cdd:PLN02736 79 MTYGEAGTARTAIGSGLVQHGIPKGACVGLYFINRPEWLIVDHACSAYS--YVSV-PLYDTLgpdAVKFIVNHAEVAAI- 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 202 fpkqFKTQQYYNVLKQICPEvenaqpgaLKSQRLpdLTTVISVDAPLPGT--------LLLDEVVAAGSTRQhldqlqyn 273
Cdd:PLN02736 155 ----FCVPQTLNTLLSCLSE--------IPSVRL--IVVVGGADEPLPSLpsgtgveiVTYSKLLAQGRSSP-------- 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 274 QQFLSC--HDPINIQFTSGTTGSPKGATLSHYNIVnnSNILGERLKLHektpeqlrmILPN-------PLYHCLGSVaGT 344
Cdd:PLN02736 213 QPFRPPkpEDVATICYTSGTTGTPKGVVLTHGNLI--ANVAGSSLSTK---------FYPSdvhisylPLAHIYERV-NQ 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 345 MMCLMYGAtlilASPIFNGK--KALEAISRERGTFLYGTPTMFVDIlnqpdfssYDISTMC----GGV------------ 406
Cdd:PLN02736 281 IVMLHYGV----AVGFYQGDnlKLMDDLAALRPTIFCSVPRLYNRI--------YDGITNAvkesGGLkerlfnaaynak 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 407 ----IAGSPAPPELIRAIINKIN---------------------MKDLVV--------AYGTTENSPVTFAHFPEDTVeq 453
Cdd:PLN02736 349 kqalENGKNPSPMWDRLVFNKIKaklggrvrfmssgasplspdvMEFLRIcfggrvleGYGMTETSCVISGMDEGDNL-- 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 454 kAESVGRIMPHTEARIMN---MEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKI 530
Cdd:PLN02736 427 -SGHVGSPNPACEVKLVDvpeMNYTSEDQPYPRGEICVRGPIIFKGYYKDEVQTREVIDEDGWLHTGDIGLWLPGGRLKI 505
|
490 500
....*....|....*....|....*
gi 572872742 531 VGRSKDMI-IRGGENIYPAELEDFF 554
Cdd:PLN02736 506 IDRKKNIFkLAQGEYIAPEKIENVY 530
|
|
| PLN02430 |
PLN02430 |
long-chain-fatty-acid-CoA ligase |
126-567 |
2.56e-16 |
|
long-chain-fatty-acid-CoA ligase
Pssm-ID: 178049 [Multi-domain] Cd Length: 660 Bit Score: 82.56 E-value: 2.56e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 126 TFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKaLVFPKQ 205
Cdd:PLN02430 78 TYKEVYEEVLQIGSALRASGAEPGSRVGIYGSNCPQWIVAMEACAAHSLICVPLYDTLGPGAVDYIVDHAEID-FVFVQD 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 206 FKTQQYYNvlkqicpevenaqPGALKSQRLPDLTTVISVDAPLPgTLLLDEVVAAGSTRQHLDQLQYNQQFLSCHDPIN- 284
Cdd:PLN02430 157 KKIKELLE-------------PDCKSAKRLKAIVSFTSVTEEES-DKASQIGVKTYSWIDFLHMGKENPSETNPPKPLDi 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 285 --IQFTSGTTGSPKGATLSHYN---IVNNSNILGERLKLHEKTPEQLRMILPnpLYHCL---------------GSVAGT 344
Cdd:PLN02430 223 ctIMYTSGTSGDPKGVVLTHEAvatFVRGVDLFMEQFEDKMTHDDVYLSFLP--LAHILdrmieeyffrkgasvGYYHGD 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 345 MMCLM-----YGATLILASP-----IFNG-KKALEAIS-RERGTF--LY-------------GTPTMFVDILnqpdfSSY 397
Cdd:PLN02430 301 LNALRddlmeLKPTLLAGVPrvferIHEGiQKALQELNpRRRLIFnaLYkyklawmnrgyshKKASPMADFL-----AFR 375
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 398 DISTMCGG-----VIAGSPAPPElIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVeqKAESVGRIMPHTEARIMNM 472
Cdd:PLN02430 376 KVKAKLGGrlrllISGGAPLSTE-IEEFLRVTSCAFVVQGYGLTETLGPTTLGFPDEMC--MLGTVGAPAVYNELRLEEV 452
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 473 EAGTLAKLNTP--GELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGENIYPAE 549
Cdd:PLN02430 453 PEMGYDPLGEPprGEICVRGKCLFSGYYKNPELTEEVM-KDGWFHTGDIGEILPNGVLKIIDRKKNLIkLSQGEYVALEY 531
|
490
....*....|....*...
gi 572872742 550 LEDFFHTHPKVQEVQVVG 567
Cdd:PLN02430 532 LENVYGQNPIVEDIWVYG 549
|
|
| PRK00174 |
PRK00174 |
acetyl-CoA synthetase; Provisional |
454-625 |
1.31e-15 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 234677 [Multi-domain] Cd Length: 637 Bit Score: 80.18 E-value: 1.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 454 KAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIR----GycVMLGYWGEPQKTEEAvdqdkwYW--------TGDVAT 521
Cdd:PRK00174 422 KPGSATRPLPGIQPAVVD-EEGNPLEGGEGGNLVIKdpwpG--MMRTIYGDHERFVKT------YFstfkgmyfTGDGAR 492
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 522 MNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVE---EIKAFC 598
Cdd:PRK00174 493 RDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKVAEAAVVGRPDDIKGQGIYAFVTLKGGEEPSDElrkELRNWV 572
|
170 180
....*....|....*....|....*..
gi 572872742 599 KGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:PRK00174 573 RKEIGPIAKPDVIQFAPGLPKTRSGKI 599
|
|
| FACL_like_1 |
cd05910 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
124-568 |
1.48e-15 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341236 [Multi-domain] Cd Length: 457 Bit Score: 79.43 E-value: 1.48e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 124 RLTFAQLKEEVDKAASGLLSIGLCKGDRLgmwgpnsyawVLMqlataqagiilvsVNPAYQAMELEYVLKKVGC-KALVF 202
Cdd:cd05910 2 RLSFRELDERSDRIAQGLTAYGIRRGMRA----------VLM-------------VPPGPDFFALTFALFKAGAvPVLID 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 203 PKQFKTQqyynvLKQICPEVEnaqpgalksqrlPDLttvisvdapLPGTLLLDEVVAagstrqhldqlqynqqflschdp 282
Cdd:cd05910 59 PGMGRKN-----LKQCLQEAE------------PDA---------FIGIPKADEPAA----------------------- 89
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 283 inIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKlhektPEQLRMILPN-PLYHCLGSVAG--TMMCLMYGATLILASP 359
Cdd:cd05910 90 --ILFTSGSTGTPKGVVYRHGTFAAQIDALRQLYG-----IRPGEVDLATfPLFALFGPALGltSVIPDMDPTRPARADP 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 360 ifngKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMK-DLVVAYGTTEN 438
Cdd:cd05910 163 ----QKLVGAIRQYGVSIVFGSPALLERVARYCAQHGITLPSLRRVLSAGAPVPIALAARLRKMLSDEaEILTPYGATEA 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 439 SPVT-------FAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTP--------GELCIRGYCVMLGYWGEPQK 503
Cdd:cd05910 239 LPVSsigsrelLATTTAATSGGAGTCVGRPIPGVRVRIIEIDDEPIAEWDDTlelprgeiGEITVTGPTVTPTYVNRPVA 318
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 572872742 504 TEEA----VDQDKWYWTGDVATMNEQG---FCkivGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGV 568
Cdd:cd05910 319 TALAkiddNSEGFWHRMGDLGYLDDEGrlwFC---GRKAHRVITTGGTLYTEPVERVFNTHPGVRRSALVGV 387
|
|
| PRK07824 |
PRK07824 |
o-succinylbenzoate--CoA ligase; |
288-633 |
2.25e-15 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 236108 [Multi-domain] Cd Length: 358 Bit Score: 78.16 E-value: 2.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 288 TSGTTGSPKGATLSHYNIVNNSNILGERLKlhekTPEQLRMILPNplYHclgsVAGtMMCLM------YGATLILASPIF 361
Cdd:PRK07824 43 TSGTTGTPKGAMLTAAALTASADATHDRLG----GPGQWLLALPA--HH----IAG-LQVLVrsviagSEPVELDVSAGF 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 362 NGKKALEAISRERGTFLYG--TPTMFVDILNQPDfSSYDISTMCGGVIAGSPAP-PELIRAIINKINmkdLVVAYGTTEN 438
Cdd:PRK07824 112 DPTALPRAVAELGGGRRYTslVPMQLAKALDDPA-ATAALAELDAVLVGGGPAPaPVLDAAAAAGIN---VVRTYGMSET 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 439 SpvtfahfpedtveqkAESV--GRIMPHTEARIMNmeagtlaklntpGELCIRGYCVMLGYWGEPQktEEAVDQDKWYWT 516
Cdd:PRK07824 188 S---------------GGCVydGVPLDGVRVRVED------------GRIALGGPTLAKGYRNPVD--PDPFAEPGWFRT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 517 GDVATMNEqGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKA 596
Cdd:PRK07824 239 DDLGALDD-GVLTVLGRADDAISTGGLTVLPQVVEAALATHPAVADCAVFGLPDDRLGQRVVAAVVGDGGPAPTLEALRA 317
|
330 340 350
....*....|....*....|....*....|....*..
gi 572872742 597 FCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:PRK07824 318 HVARTLDRTAAPRELHVVDELPRRGIGKVDRRALVRR 354
|
|
| PRK06334 |
PRK06334 |
long chain fatty acid--[acyl-carrier-protein] ligase; Validated |
285-557 |
2.33e-15 |
|
long chain fatty acid--[acyl-carrier-protein] ligase; Validated
Pssm-ID: 180533 [Multi-domain] Cd Length: 539 Bit Score: 79.09 E-value: 2.33e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 285 IQFTSGTTGSPKGATLSHYNIVNNSNILgerLKLHEKTpEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNGK 364
Cdd:PRK06334 188 ILFTSGTEKLPKGVPLTHANLLANQRAC---LKFFSPK-EDDVMMSFLPPFHAYGFNSCTLFPLLSGVPVVFAYNPLYPK 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 365 KALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFA 444
Cdd:PRK06334 264 KIVEMIDEAKVTFLGSTPVFFDYILKTAKKQESCLPSLRFVVIGGDAFKDSLYQEALKTFPHIQLRQGYGTTECSPVITI 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 445 hfpeDTVE--QKAESVGriMPHTEARIMNMEAGTLAKLNT--PGELCIRGYCVMLGYWGE-PQKTEEAVDQDKWYWTGDV 519
Cdd:PRK06334 344 ----NTVNspKHESCVG--MPIRGMDVLIVSEETKVPVSSgeTGLVLTRGTSLFSGYLGEdFGQGFVELGGETWYVTGDL 417
|
250 260 270
....*....|....*....|....*....|....*...
gi 572872742 520 ATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTH 557
Cdd:PRK06334 418 GYVDRHGELFLKGRLSRFVKIGAEMVSLEALESILMEG 455
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
229-627 |
1.82e-14 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 77.52 E-value: 1.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 229 ALKSQRLPDLTT-------VISVDAPLPGTLLLDEVVAAGSTR-------QHLDQLQYNQQFLSCHDPIN-IQFTSGTTG 293
Cdd:PRK05691 3803 GLPAQRLQRIIElsrtpvlVCSAACREQARALLDELGCANRPRllvweevQAGEVASHNPGIYSGPDNLAyVIYTSGSTG 3882
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 294 SPKGATLSHYNIVNNSNILGERLKLHE-----KTPEQLRMIlpnplyhclgSVAGTMMCLMYGATL-ILASPIFNGKKAL 367
Cdd:PRK05691 3883 LPKGVMVEQRGMLNNQLSKVPYLALSEadviaQTASQSFDI----------SVWQFLAAPLFGARVeIVPNAIAHDPQGL 3952
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 368 EAISRERG-TFLYGTPTMFVDILNQPDFSSYDISTMcggVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPvTFAHF 446
Cdd:PRK05691 3953 LAHVQAQGiTVLESVPSLIQGMLAEDRQALDGLRWM---LPTGEAMPPELARQWLQRYPQIGLVNAYGPAECSD-DVAFF 4028
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 447 PEDTVEQKAESVGRIMPHTEARIMNM-EAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEA-------VDQDKWYWTGD 518
Cdd:PRK05691 4029 RVDLASTRGSYLPIGSPTDNNRLYLLdEALELVPLGAVGELCVAGTGVGRGYVGDPLRTALAfvphpfgAPGERLYRTGD 4108
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 519 VATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVqVVGVKDDRMGEEICACIRLKDGEETT---VEEIK 595
Cdd:PRK05691 4109 LARRRSDGVLEYVGRIDHQVKIRGYRIELGEIEARLHEQAEVREA-AVAVQEGVNGKHLVGYLVPHQTVLAQgalLERIK 4187
|
410 420 430
....*....|....*....|....*....|..
gi 572872742 596 AFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 627
Cdd:PRK05691 4188 QRLRAELPDYMVPLHWLWLDRLPLNANGKLDR 4219
|
|
| PRK05850 |
PRK05850 |
acyl-CoA synthetase; Validated |
103-625 |
8.00e-14 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235624 [Multi-domain] Cd Length: 578 Bit Score: 74.59 E-value: 8.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 103 LETTAQRVPEREALVVLHEDVR-------LTFAQLKEEVDKAASGLLSIGLcKGDRLGMWGPNSYAWVLMQLATAQAGII 175
Cdd:PRK05850 7 LRERASLQPDDAAFTFIDYEQDpagvaetLTWSQLYRRTLNVAEELRRHGS-TGDRAVILAPQGLEYIVAFLGALQAGLI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 176 LV--SVnPAYQAMEleyvlKKVG-----CKALVfpkqfktqqyynVL--KQICPEV-ENAQPGALKSQrlpdlTTVISVD 245
Cdd:PRK05850 86 AVplSV-PQGGAHD-----ERVSavlrdTSPSV------------VLttSAVVDDVtEYVAPQPGQSA-----PPVIEVD 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 246 aplpgTLLLDEVVAAGSTRQHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYN-IVNNSNILGERLKLHEKTPE 324
Cdd:PRK05850 143 -----LLDLDSPRGSDARPRDLPSTAY------------LQYTSGSTRTPAGVMVSHRNvIANFEQLMSDYFGDTGGVPP 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 325 QLRMI---LPnpLYHCLGSVAGTMMCLMYGATLILASPI-FNGKKA--LEAISRERGTFLYGTPTMF---VDILNQPDFS 395
Cdd:PRK05850 206 PDTTVvswLP--FYHDMGLVLGVCAPILGGCPAVLTSPVaFLQRPArwMQLLASNPHAFSAAPNFAFelaVRKTSDDDMA 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 396 SYDISTMCGgVIAGS----PAPpelIRAIIN---KINMKDLVV--AYGTTE----------NSPVTFAHF-PEDTVEQKA 455
Cdd:PRK05850 284 GLDLGGVLG-IISGServhPAT---LKRFADrfaPFNLRETAIrpSYGLAEatvyvatrepGQPPESVRFdYEKLSAGHA 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 456 ES---------VGRIMPHTEA-RIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTE-----------EAVDQDKWY 514
Cdd:PRK05850 360 KRcetgggtplVSYGSPRSPTvRIVDPDTCIECPAGTVGEIWVHGDNVAAGYWQKPEETErtfgatlvdpsPGTPEGPWL 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 515 WTGDVATMNEQGFCkIVGRSKDMIIRGGENIYPAELEdffhthPKVQE-----VQVVGVKDDRmGEEICACIRLKDGEET 589
Cdd:PRK05850 440 RTGDLGFISEGELF-IVGRIKDLLIVDGRNHYPDDIE------ATIQEitggrVAAISVPDDG-TEKLVAIIELKKRGDS 511
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 572872742 590 TVEEIKAFC--KGKI------SHFKIPKYIVFVT--NYPLTISGKI 625
Cdd:PRK05850 512 DEEAMDRLRtvKREVtsaiskSHGLSVADLVLVApgSIPITTSGKI 557
|
|
| PLN02614 |
PLN02614 |
long-chain acyl-CoA synthetase |
126-567 |
1.47e-13 |
|
long-chain acyl-CoA synthetase
Pssm-ID: 166255 [Multi-domain] Cd Length: 666 Bit Score: 73.90 E-value: 1.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 126 TFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCkALVFPKQ 205
Cdd:PLN02614 81 TYQEVYDIVIKLGNSLRSVGVKDEAKCGIYGANSPEWIISMEACNAHGLYCVPLYDTLGAGAVEFIISHSEV-SIVFVEE 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 206 FKTQQYYnvlkQICPEVENAQP-----GALKSQRLPDLTTVISVdaplpgTLLLDEVVAAGSTRQhldqlqYNQQFLSCH 280
Cdd:PLN02614 160 KKISELF----KTCPNSTEYMKtvvsfGGVSREQKEEAETFGLV------IYAWDEFLKLGEGKQ------YDLPIKKKS 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 281 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLK-LHEKTPEQLRMILPNPLYHC---------------------- 337
Cdd:PLN02614 224 DICTIMYTSGTTGDPKGVMISNESIVTLIAGVIRLLKsANAALTVKDVYLSYLPLAHIfdrvieecfiqhgaaigfwrgd 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 338 -------LGSVAGTMMC--------LMYGATLILASPIFNGKKALE-AISRERGTFLYGTPtmfvDILNQPDFSSYDIST 401
Cdd:PLN02614 304 vklliedLGELKPTIFCavprvldrVYSGLQKKLSDGGFLKKFVFDsAFSYKFGNMKKGQS----HVEASPLCDKLVFNK 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 402 MCGG-------VIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTveQKAESVGRIMPHTEARIMN--- 471
Cdd:PLN02614 380 VKQGlggnvriILSGAAPLASHVESFLRVVACCHVLQGYGLTESCAGTFVSLPDEL--DMLGTVGPPVPNVDIRLESvpe 457
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 472 MEAGTLAklNTP-GELCIRGYCVMLGYWGEPQKTEEaVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGENIYPAE 549
Cdd:PLN02614 458 MEYDALA--STPrGEICIRGKTLFSGYYKREDLTKE-VLIDGWLHTGDVGEWQPNGSMKIIDRKKNIFkLSQGEYVAVEN 534
|
490
....*....|....*...
gi 572872742 550 LEDFFHTHPKVQEVQVVG 567
Cdd:PLN02614 535 IENIYGEVQAVDSVWVYG 552
|
|
| PLN02861 |
PLN02861 |
long-chain-fatty-acid-CoA ligase |
85-567 |
1.48e-13 |
|
long-chain-fatty-acid-CoA ligase
Pssm-ID: 178452 [Multi-domain] Cd Length: 660 Bit Score: 73.72 E-value: 1.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 85 YVQGCTKKHLNSKTVGQCLETTAQRVPErealvvlhedVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVL 164
Cdd:PLN02861 48 FFSDAVKKYPNNQMLGRRQVTDSKVGPY----------VWLTYKEVYDAAIRIGSAIRSRGVNPGDRCGIYGSNCPEWII 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 165 MQLATAQAGIILVSVNPAYQAMELEYVLKKVGCkALVFPKQFKTQQYYNVLKQiCpeveNAQPGALKSqrLPDLTTVISV 244
Cdd:PLN02861 118 AMEACNSQGITYVPLYDTLGANAVEFIINHAEV-SIAFVQESKISSILSCLPK-C----SSNLKTIVS--FGDVSSEQKE 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 245 DAPLPGTLLL--DEVVAAGSTRQHLDQLQYNqqflschDPINIQFTSGTTGSPKGAtlshynIVNNSNILGERLKLHEKT 322
Cdd:PLN02861 190 EAEELGVSCFswEEFSLMGSLDCELPPKQKT-------DICTIMYTSGTTGEPKGV------ILTNRAIIAEVLSTDHLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 323 PEQLRMILPN-------PLYHCLGSVAGTMmCLMYGATLilasPIFNG--KKALEAISRERGTFLYGTPTMFVDI---LN 390
Cdd:PLN02861 257 KVTDRVATEEdsyfsylPLAHVYDQVIETY-CISKGASI----GFWQGdiRYLMEDVQALKPTIFCGVPRVYDRIytgIM 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 391 QP------------DFS-SYDISTMCGGvIAGSPAPPELIRAIINKI-----------------------------NMKD 428
Cdd:PLN02861 332 QKissggmlrkklfDFAyNYKLGNLRKG-LKQEEASPRLDRLVFDKIkeglggrvrlllsgaaplprhveeflrvtSCSV 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 429 LVVAYGTTENSPVTFAHFPEdtVEQKAESVGRIMPHTEARIMNM-EAGTLAKLNTP-GELCIRGYCVMLGYWGEPQKTEE 506
Cdd:PLN02861 411 LSQGYGLTESCGGCFTSIAN--VFSMVGTVGVPMTTIEARLESVpEMGYDALSDVPrGEICLRGNTLFSGYHKRQDLTEE 488
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 572872742 507 AVdQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGENIYPAELEDFFHTHPKVQEVQVVG 567
Cdd:PLN02861 489 VL-IDGWFHTGDIGEWQPNGAMKIIDRKKNIFkLSQGEYVAVENLENTYSRCPLIASIWVYG 549
|
|
| hsFATP4_like |
cd05939 |
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty ... |
122-633 |
1.13e-12 |
|
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes FATP4, FATP1, and homologous proteins. Each FATP has unique patterns of tissue distribution. FATP4 is mainly expressed in the brain, testis, colon and kidney. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341262 [Multi-domain] Cd Length: 474 Bit Score: 70.53 E-value: 1.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 122 DVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVNPAYQAMELEYVLKKVGCKALV 201
Cdd:cd05939 1 DRHWTFRELNEYSNKVANFFQAQGYRSGDVVALFMENRLEFVALWLGLAKIGVETALINSNLRLESLLHCITVSKAKALI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 202 FpkqfktqqyynvlkqicpevenaqpgalksQRLPDLTTVISVDAPlpgtllldevvaagstrqhldqlqyNQQFLSCHD 281
Cdd:cd05939 81 F------------------------------NLLDPLLTQSSTEPP-------------------------SQDDVNFRD 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 282 PINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGATLILASPiF 361
Cdd:cd05939 106 KLFYIYTSGTTGLPKAAVIVHSRYYRIAAGAYYAFGMRPED----VVYDCLPLYHSAGGIMGVGQALLHGSTVVIRKK-F 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 362 NGKKALEAISRERGTFLYGTPTMFVDILNQPdfSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTE-NSP 440
Cdd:cd05939 181 SASNFWDDCVKYNCTIVQYIGEICRYLLAQP--PSEEEQKHNVRLAVGNGLRPQIWEQFVRRFGIPQIGEFYGATEgNSS 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 441 VTfahfpedTVEQKAESVG---RIMPHT-EARIMNMEAGTLAKLNTPGELCIR------GYCV-----------MLGYWG 499
Cdd:cd05939 259 LV-------NIDNHVGACGfnsRILPSVyPIRLIKVDEDTGELIRDSDGLCIPcqpgepGLLVgkiiqndplrrFDGYVN 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 500 EP---QKTEEAVDQ--DKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRM- 573
Cdd:cd05939 332 EGatnKKIARDVFKkgDSAFLSGDVLVMDELGYLYFKDRTGDTFRWKGENVSTTEVEGILSNVLGLEDVVVYGVEVPGVe 411
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 574 GEEICACIRLKDgEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 633
Cdd:cd05939 412 GRAGMAAIVDPE-RKVDLDRFSAVLAKSLPPYARPQFIRLLPEVDKTGTFKLQKTDLQKE 470
|
|
| PLN02387 |
PLN02387 |
long-chain-fatty-acid-CoA ligase family protein |
117-565 |
3.17e-12 |
|
long-chain-fatty-acid-CoA ligase family protein
Pssm-ID: 215217 [Multi-domain] Cd Length: 696 Bit Score: 69.76 E-value: 3.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 117 VVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILVSVnpaYQAMeleyvlkkvG 196
Cdd:PLN02387 99 LHLGEYEWITYGQVFERVCNFASGLVALGHNKEERVAIFADTRAEWLIALQGCFRQNITVVTI---YASL---------G 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 197 CKALVFPKQfKTQqyynVLKQICPEVENAQPGALkSQRLPDLTTVI-----SVDAPLPGTLLLDEVVAAGSTRQHLDQLQ 271
Cdd:PLN02387 167 EEALCHSLN-ETE----VTTVICDSKQLKKLIDI-SSQLETVKRVIymddeGVDSDSSLSGSSNWTVSSFSEVEKLGKEN 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 272 YNQQFL-SCHDPINIQFTSGTTGSPKGATLSHYNIVnnsnilgerlklheKTPEQLRMILPN-----------PLYHCLG 339
Cdd:PLN02387 241 PVDPDLpSPNDIAVIMYTSGSTGLPKGVMMTHGNIV--------------ATVAGVMTVVPKlgkndvylaylPLAHILE 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 340 SVAGTMMC-----LMYGATLIL---ASPIFNGKK------------ALEAI-SRER------------------------ 374
Cdd:PLN02387 307 LAAESVMAavgaaIGYGSPLTLtdtSNKIKKGTKgdasalkptlmtAVPAIlDRVRdgvrkkvdakgglakklfdiaykr 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 375 ------GTFL--YGTPTMFVDILNqpdFSSydISTMCGGVI-----AGSPAPPELIRaIINkINMKDLVV-AYGTTEN-S 439
Cdd:PLN02387 387 rlaaieGSWFgaWGLEKLLWDALV---FKK--IRAVLGGRIrfmlsGGAPLSGDTQR-FIN-ICLGAPIGqGYGLTETcA 459
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 440 PVTFAHFpEDTveqkaeSVGRI---MPHTEARIMNMEAGTLAKLNTP---GELCIRGYCVMLGYWGEPQKTEEA--VDQD 511
Cdd:PLN02387 460 GATFSEW-DDT------SVGRVgppLPCCYVKLVSWEEGGYLISDKPmprGEIVIGGPSVTLGYFKNQEKTDEVykVDER 532
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 572872742 512 --KWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGENIYPAELEDFFHTHPKVQEVQV 565
Cdd:PLN02387 533 gmRWFYTGDIGQFHPDGCLEIIDRKKDIVkLQHGEYVSLGKVEAALSVSPYVDNIMV 589
|
|
| PTZ00342 |
PTZ00342 |
acyl-CoA synthetase; Provisional |
280-545 |
4.26e-12 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 240370 [Multi-domain] Cd Length: 746 Bit Score: 69.36 E-value: 4.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 280 HDP---INIQFTSGTTGSPKGATLSHYNIVN------NSNIlgeRLKLHEKTpeQLRMIlpnPLYHCLGSVAgTMMCLMY 350
Cdd:PTZ00342 301 EDPdfiTSIVYTSGTSGKPKGVMLSNKNLYNtvvplcKHSI---FKKYNPKT--HLSYL---PISHIYERVI-AYLSFML 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 351 GATLILASP---IFNgkkalEAISRERGTFLYGTPTMF--------VDILNQPDFSSYDI--------STMCGG------ 405
Cdd:PTZ00342 372 GGTINIWSKdinYFS-----KDIYNSKGNILAGVPKVFnriytnimTEINNLPPLKRFLVkkilslrkSNNNGGfskfle 446
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 406 ------------------VI--AGSPAPPELIRAIINKINMKdLVVAYGTTENspvTFAHFPEDTVEQKAESVG-RIMPH 464
Cdd:PTZ00342 447 githisskikdkvnpnleVIlnGGGKLSPKIAEELSVLLNVN-YYQGYGLTET---TGPIFVQHADDNNTESIGgPISPN 522
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 465 TEARIMNMEAGTlAKLNTP-GELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGG 542
Cdd:PTZ00342 523 TKYKVRTWETYK-ATDTLPkGELLIKSDSIFSGYFLEKEQTKNAFTEDGYFKTGDIVQINKNGSLTFLDRSKGLVkLSQG 601
|
...
gi 572872742 543 ENI 545
Cdd:PTZ00342 602 EYI 604
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
101-627 |
1.13e-11 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 68.66 E-value: 1.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 101 QCL----ETTAQRVPEREALVVLHEdvRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIIL 176
Cdd:PRK05691 2188 QTLhglfAAQAARTPQAPALTFAGQ--TLSYAELDARANRLARALRERGVGPQVRVGLALERSLEMVVGLLAILKAGGAY 2265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 177 VSVNPAYQAMELEYVLKKVGCKALVfpkqfKTQQYYNVLKQICPEV-----ENAQPgALKSQRlpdlttvisvDAPLPGT 251
Cdd:PRK05691 2266 VPLDPEYPLERLHYMIEDSGIGLLL-----SDRALFEALGELPAGVarwclEDDAA-ALAAYS----------DAPLPFL 2329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 252 llldevvaagSTRQHLDQLQYnqqflschdpiniqfTSGTTGSPKGATLSHYNIVNNSNILGERL-------KLH----- 319
Cdd:PRK05691 2330 ----------SLPQHQAYLIY---------------TSGSTGKPKGVVVSHGEIAMHCQAVIERFgmraddcELHfysin 2384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 320 -EKTPEqlRMILPnplyhclgsvagtmmcLMYGATLILASpifNGKKALEAIS---RERGTFLYG-TPTmFVDILNQPDF 394
Cdd:PRK05691 2385 fDAASE--RLLVP----------------LLCGARVVLRA---QGQWGAEEICqliREQQVSILGfTPS-YGSQLAQWLA 2442
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 395 SSYDIST--MCggVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAESV--GRIMPHTEARIM 470
Cdd:PRK05691 2443 GQGEQLPvrMC--ITGGEALTGEHLQRIRQAFAPQLFFNAYGPTETVVMPLACLAPEQLEEGAASVpiGRVVGARVAYIL 2520
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 471 NMEAGTLAKLNTpGELCIRGYCVMLGYWGEPQKTEE-------AVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGG 542
Cdd:PRK05691 2521 DADLALVPQGAT-GELYVGGAGLAQGYHDRPGLTAErfvadpfAADGGRLYRTGDLVRLRADGLVEYVGRIDHQVkIRGF 2599
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 543 EnIYPAELEDFFHTHPKVQEVQVVGVkDDRMGEEIC---ACIRLKDGEETTV---EEIKAFCKGKISHFKIPKYIVFVTN 616
Cdd:PRK05691 2600 R-IELGEIESRLLEHPAVREAVVLAL-DTPSGKQLAgylVSAVAGQDDEAQAalrEALKAHLKQQLPDYMVPAHLILLDS 2677
|
570
....*....|.
gi 572872742 617 YPLTISGKIQK 627
Cdd:PRK05691 2678 LPLTANGKLDR 2688
|
|
| PLN02654 |
PLN02654 |
acetate-CoA ligase |
513-639 |
2.62e-11 |
|
acetate-CoA ligase
Pssm-ID: 215353 [Multi-domain] Cd Length: 666 Bit Score: 66.84 E-value: 2.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 513 WYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVE 592
Cdd:PLN02654 514 YYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVSHPQCAEAAVVGIEHEVKGQGIYAFVTLVEGVPYSEE 593
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 572872742 593 EIKAF---CKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMERHLN 639
Cdd:PLN02654 594 LRKSLiltVRNQIGAFAAPDKIHWAPGLPKTRSGKIMRRILRKIASRQLD 643
|
|
| prpE |
PRK10524 |
propionyl-CoA synthetase; Provisional |
107-625 |
5.20e-11 |
|
propionyl-CoA synthetase; Provisional
Pssm-ID: 182517 [Multi-domain] Cd Length: 629 Bit Score: 65.74 E-value: 5.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 107 AQRvPEREALVVL----HEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAGIILvSVnpa 182
Cdd:PRK10524 64 AKR-PEQLALIAVstetDEERTYTFRQLHDEVNRMAAMLRSLGVQRGDRVLIYMPMIAEAAFAMLACARIGAIH-SV--- 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 183 yqameleyvlkkvgckalVFpKQFKTQqyyNVLKQIcpevENAQPgalksqrlpdlTTVISVDA------PLPGTLLLDE 256
Cdd:PRK10524 139 ------------------VF-GGFASH---SLAARI----DDAKP-----------VLIVSADAgsrggkVVPYKPLLDE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 257 VVAAGST-----------------------------RQHLDQlQYNQQFLSCHDPINIQFTSGTTGSPKG---------- 297
Cdd:PRK10524 182 AIALAQHkprhvllvdrglapmarvagrdvdyatlrAQHLGA-RVPVEWLESNEPSYILYTSGTTGKPKGvqrdtggyav 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 298 ---ATLSHynivnnsnILGerlklhektpeqlrmilpnplyhclGSVAGTMMCL-----MYGATLILASPIFNGKkalea 369
Cdd:PRK10524 261 alaTSMDT--------IFG-------------------------GKAGETFFCAsdigwVVGHSYIVYAPLLAGM----- 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 370 isrerGTFLY-GTPT------------------MF-----VDILNQPD---FSSYDISTMCGGVIAGSPAPPELIRAIIN 422
Cdd:PRK10524 303 -----ATIMYeGLPTrpdagiwwrivekykvnrMFsaptaIRVLKKQDpalLRKHDLSSLRALFLAGEPLDEPTASWISE 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 423 KINmKDLVVAYGTTENSPVTFAHFP--EDTvEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGY----CvMLG 496
Cdd:PRK10524 378 ALG-VPVIDNYWQTETGWPILAIARgvEDR-PTRLGSPGVPMYGYNVKLLNEVTGEPCGPNEKGVLVIEGPlppgC-MQT 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 497 YWGepqkteeavDQDKW---YW---------TGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQ 564
Cdd:PRK10524 455 VWG---------DDDRFvktYWslfgrqvysTFDWGIRDADGYYFILGRTDDVINVAGHRLGTREIEESISSHPAVAEVA 525
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 572872742 565 VVGVKDDRMGEEICACIRLKDGEETTVE--------EIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 625
Cdd:PRK10524 526 VVGVKDALKGQVAVAFVVPKDSDSLADRearlalekEIMALVDSQLGAVARPARVWFVSALPKTRSGKL 594
|
|
| PTZ00237 |
PTZ00237 |
acetyl-CoA synthetase; Provisional |
278-627 |
1.67e-09 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 240325 [Multi-domain] Cd Length: 647 Bit Score: 60.91 E-value: 1.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 278 SCHdPINIQFTSGTTGSPKGATLShynivNNSNILGerLKLHEKTPEQLRMILPNPLYHCLGSVAGTMM---CLMYGATL 354
Cdd:PTZ00237 253 SSH-PLYILYTSGTTGNSKAVVRS-----NGPHLVG--LKYYWRSIIEKDIPTVVFSHSSIGWVSFHGFlygSLSLGNTF 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 355 ILASPIFNGKKALE-----AISRER-GTFLYGTPTMFVDILNQPD----FSSYDISTMCGGVIAGSPAPPELIRAIINKI 424
Cdd:PTZ00237 325 VMFEGGIIKNKHIEddlwnTIEKHKvTHTLTLPKTIRYLIKTDPEatiiRSKYDLSNLKEIWCGGEVIEESIPEYIENKL 404
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 425 NMKDLVVaYGTTENSPVTFAHFPEDTVEQKAesVGRIMPHTEARIMNmEAGTLAKLNTPGELCIR-----GYCVMLgywg 499
Cdd:PTZ00237 405 KIKSSRG-YGQTEIGITYLYCYGHINIPYNA--TGVPSIFIKPSILS-EDGKELNVNEIGEVAFKlpmppSFATTF---- 476
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 500 epQKTEEAVDQ-----DKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMG 574
Cdd:PTZ00237 477 --YKNDEKFKQlfskfPGYYNSGDLGFKDENGYYTIVSRSDDQIKISGNKVQLNTIETSILKHPLVLECCSIGIYDPDCY 554
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 575 EEICACIRLKDGEETTV-------EEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 627
Cdd:PTZ00237 555 NVPIGLLVLKQDQSNQSidlnklkNEINNIITQDIESLAVLRKIIIVNQLPKTKTGKIPR 614
|
|
| PRK12476 |
PRK12476 |
putative fatty-acid--CoA ligase; Provisional |
249-551 |
8.28e-09 |
|
putative fatty-acid--CoA ligase; Provisional
Pssm-ID: 171527 [Multi-domain] Cd Length: 612 Bit Score: 58.60 E-value: 8.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 249 PGTLLLDEV---VAAGSTRQHLDqlqynqqflsCHDPINIQFTSGTTGSPKGATLSHYNIVNNSnilgerlklhektpeq 325
Cdd:PRK12476 169 PRVIAIDAIpdsAGESFVPVELD----------TDDVSHLQYTSGSTRPPVGVEITHRAVGTNL---------------- 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 326 LRMIL------PN-------PLYHCLGsVAGTMMCLMYGATLILASPI-FNGK-----KALEAISRERGTFLyGTPTMFV 386
Cdd:PRK12476 223 VQMILsidlldRNthgvswlPLYHDMG-LSMIGFPAVYGGHSTLMSPTaFVRRpqrwiKALSEGSRTGRVVT-AAPNFAY 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 387 DILNQ----PDFSSYDISTMCggVIAGS-PAPPELIRAIiNKI----NMKDLVV--AYGTTE----------NSPVTFAH 445
Cdd:PRK12476 301 EWAAQrglpAEGDDIDLSNVV--LIIGSePVSIDAVTTF-NKAfapyGLPRTAFkpSYGIAEatlfvatiapDAEPSVVY 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 446 F-------------PEDTVEQKAE-SVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEE----- 506
Cdd:PRK12476 378 LdreqlgagravrvAADAPNAVAHvSCGQVARSQWAVIVDPDTGAELPDGEVGEIWLHGDNIGRGYWGRPEETERtfgak 457
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 572872742 507 -------------AVDQDKWYWTGDVATMNEqGFCKIVGRSKDMIIRGGENIYPAELE 551
Cdd:PRK12476 458 lqsrlaegshadgAADDGTWLRTGDLGVYLD-GELYITGRIADLIVIDGRNHYPQDIE 514
|
|
| PRK07769 |
PRK07769 |
long-chain-fatty-acid--CoA ligase; Validated |
241-551 |
2.05e-08 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 181109 [Multi-domain] Cd Length: 631 Bit Score: 57.43 E-value: 2.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 241 VISVDApLPgtlllDEVvaaGSTRQ----HLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERL 316
Cdd:PRK07769 158 VIAVDA-VP-----DEV---GATWVppeaNEDTIAY------------LQYTSGSTRIPAGVQITHLNLPTNVLQVIDAL 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 317 KLHEKTpeqlRMILPNPLYHCLGSVAgTMMCLMYGATLILASPI-FNGK-----KALEAISRERGTFLYGTPTMFVDI-- 388
Cdd:PRK07769 217 EGQEGD----RGVSWLPFFHDMGLIT-VLLPALLGHYITFMSPAaFVRRpgrwiRELARKPGGTGGTFSAAPNFAFEHaa 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 389 ---LNQPDFSSYDISTMcGGVIAGS-PAPPELIR--------------AIINKINMKD--LVVAYGTTENSPvTFAHFPE 448
Cdd:PRK07769 292 argLPKDGEPPLDLSNV-KGLLNGSePVSPASMRkfneafapyglpptAIKPSYGMAEatLFVSTTPMDEEP-TVIYVDR 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 449 DT--------VEQKAE------SVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEE-------- 506
Cdd:PRK07769 370 DElnagrfveVPADAPnavaqvSAGKVGVSEWAVIVDPETASELPDGQIGEIWLHGNNIGTGYWGKPEETAAtfqnilks 449
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 572872742 507 ---------AVDQDKWYWTGDVATMNEqGFCKIVGRSKDMIIRGGENIYPAELE 551
Cdd:PRK07769 450 rlseshaegAPDDALWVRTGDYGVYFD-GELYITGRVKDLVIIDGRNHYPQDLE 502
|
|
| PaaK |
COG1541 |
Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and ... |
288-573 |
4.52e-07 |
|
Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and metabolism];
Pssm-ID: 441150 [Multi-domain] Cd Length: 423 Bit Score: 52.46 E-value: 4.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 288 TSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLrmilpnpLYHCLG---SVAGTMM---CLMYGATLILASPIf 361
Cdd:COG1541 91 SSGTTGKPTVVGYTRKDLDRWAELFARSLRAAGVRPGDR-------VQNAFGyglFTGGLGLhygAERLGATVIPAGGG- 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 362 NGKKALEAISRERGTFLYGTPTMFVDILNQP-----DFSSYDISTmcgGVIAGSPAPPELIRAIINKINMKdLVVAYGTT 436
Cdd:COG1541 163 NTERQLRLMQDFGPTVLVGTPSYLLYLAEVAeeegiDPRDLSLKK---GIFGGEPWSEEMRKEIEERWGIK-AYDIYGLT 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 437 ENSPVTFA--------HFPEDTVeqkaesvgrimpHTEarIMNMEAGTLAKLNTPGEL-----------CIRgycvmlgy 497
Cdd:COG1541 239 EVGPGVAYeceaqdglHIWEDHF------------LVE--IIDPETGEPVPEGEEGELvvttltkeampLIR-------- 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 498 wgepqkteeavdqdkwYWTGDVATMNEqGFC----------KIVGRSKDMIIRGGENIYPAELEDFFHTHPKV-QEVQVV 566
Cdd:COG1541 297 ----------------YRTGDLTRLLP-EPCpcgrthprigRILGRADDMLIIRGVNVFPSQIEEVLLRIPEVgPEYQIV 359
|
....*..
gi 572872742 567 GVKDDRM 573
Cdd:COG1541 360 VDREGGL 366
|
|
| alpha_am_amid |
TIGR03443 |
L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are ... |
287-630 |
9.85e-06 |
|
L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31), product of the LYS2 gene. It is also called alpha-aminoadipate reductase. In fungi, lysine is synthesized via aminoadipate. Currently, all members of this family are fungal.
Pssm-ID: 274582 [Multi-domain] Cd Length: 1389 Bit Score: 48.91 E-value: 9.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 287 FTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKT-----------PEQLRMILPnplyhclgsvagtmmcLMYGATLI 355
Cdd:TIGR03443 422 FTSGSEGIPKGVLGRHFSLAYYFPWMAKRFGLSENDkftmlsgiahdPIQRDMFTP----------------LFLGAQLL 485
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 356 L--ASPIFNGKKALEAISRERGTFLYGTPTM-------------------FV-DILNQPDFSSydISTMCGGViagspap 413
Cdd:TIGR03443 486 VptADDIGTPGRLAEWMAKYGATVTHLTPAMgqllsaqattpipslhhafFVgDILTKRDCLR--LQTLAENV------- 556
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 414 peliraiiNKINMkdlvvaYGTTENS-PVTFAHFP----EDTVEQKAESV---GRIMPHTEARIMNMEAGT-LAKLNTPG 484
Cdd:TIGR03443 557 --------CIVNM------YGTTETQrAVSYFEIPsrssDSTFLKNLKDVmpaGKGMKNVQLLVVNRNDRTqTCGVGEVG 622
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 485 ELCIRGYCVMLGYWGEPQKTEEA------VDQDKW----------------------YWTGDVATMNEQGFCKIVGRSKD 536
Cdd:TIGR03443 623 EIYVRAGGLAEGYLGLPELNAEKfvnnwfVDPSHWidldkennkperefwlgprdrlYRTGDLGRYLPDGNVECCGRADD 702
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 537 MI-IRGGEnIYPAELEDFFHTHPKVQEvQVVGVKDDRMGE--------------EICACIRLKDGEETT----------- 590
Cdd:TIGR03443 703 QVkIRGFR-IELGEIDTHLSQHPLVRE-NVTLVRRDKDEEptlvsyivpqdksdELEEFKSEVDDEESSdpvvkglikyr 780
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 572872742 591 --VEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 630
Cdd:TIGR03443 781 klIKDIREYLKKKLPSYAIPTVIVPLKKLPLNPNGKVDKPAL 822
|
|
| PaaK |
cd05913 |
Phenylacetate-CoA ligase (also known as PaaK); PaaK catalyzes the first step in the aromatic ... |
514-606 |
1.75e-04 |
|
Phenylacetate-CoA ligase (also known as PaaK); PaaK catalyzes the first step in the aromatic degradation pathway, by converting phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Phenylacetate-CoA ligase has been found in proteobacteria as well as gram positive prokaryotes. The enzyme is specifically induced after aerobic growth in a chemically defined medium containing PA or phenylalanine (Phe) as the sole carbon source. PaaKs are members of the adenylate-forming enzyme (AFE) family. However, sequence comparison reveals divergent features of PaaK with respect to the superfamily, including a novel N-terminal sequence.
Pssm-ID: 341239 [Multi-domain] Cd Length: 425 Bit Score: 44.54 E-value: 1.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572872742 514 YWTGDVATMN-EQGFC--------KIVGRSKDMIIRGGENIYPAELEDFFHTHPKV-QEVQVVGVKDDRMGEeicacIRL 583
Cdd:cd05913 293 YRTRDITRLLpGPCPCgrthrridRITGRSDDMLIIRGVNVFPSQIEDVLLKIPGLgPHYQLILTRQEHLDE-----LTI 367
|
90 100
....*....|....*....|....*.
gi 572872742 584 K---DGEETTVEEIKAFCKGKISHFK 606
Cdd:cd05913 368 KvevRPEADDDEKLEALKQRLERHIK 393
|
|
| |
