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Conserved domains on  [gi|576067743|ref|NP_001276572|]
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secretoglobin family 3A member 2 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCGB3A pfam20490
Secretoglobin 3A; This family includes secretoglobin family 3A member 1 (SCGB3A1) and member 2 ...
 20-85 3.54e-29

Secretoglobin 3A; This family includes secretoglobin family 3A member 1 (SCGB3A1) and member 2 (SCGB3A2), also known as uteroglobin-related proteins. They are a small secreted proteins expressed in airway epithelial cells. SCGB3A2, also known as UGRP1, has an important anti-inflammatory activity and is involved in asthma. SCGB3A2 mediates its anti-inflammatory action through inhibition of ERK and JNK activation. It is also involved in lung development and has anti-fibrotic activity in lung.


:

Pssm-ID: 466639  Cd Length: 68  Bit Score: 100.00  E-value: 3.54e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 576067743   20 TALLINRL--PVVDKLPVPLDDIIPSFDPLKMLLKTLGISVEHLVTGLKKCVDELGPEASEAVKKLLV 85
Cdd:pfam20490   1 AAFFVNSVakPVAALAPLPLDSILPFFNPLKLLLTSLGIPVEHLVEGSRKCVAELGPEAVEAVKKLLG 68
 
Name Accession Description Interval E-value
SCGB3A pfam20490
Secretoglobin 3A; This family includes secretoglobin family 3A member 1 (SCGB3A1) and member 2 ...
 20-85 3.54e-29

Secretoglobin 3A; This family includes secretoglobin family 3A member 1 (SCGB3A1) and member 2 (SCGB3A2), also known as uteroglobin-related proteins. They are a small secreted proteins expressed in airway epithelial cells. SCGB3A2, also known as UGRP1, has an important anti-inflammatory activity and is involved in asthma. SCGB3A2 mediates its anti-inflammatory action through inhibition of ERK and JNK activation. It is also involved in lung development and has anti-fibrotic activity in lung.


Pssm-ID: 466639  Cd Length: 68  Bit Score: 100.00  E-value: 3.54e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 576067743   20 TALLINRL--PVVDKLPVPLDDIIPSFDPLKMLLKTLGISVEHLVTGLKKCVDELGPEASEAVKKLLV 85
Cdd:pfam20490   1 AAFFVNSVakPVAALAPLPLDSILPFFNPLKLLLTSLGIPVEHLVEGSRKCVAELGPEAVEAVKKLLG 68
 
Name Accession Description Interval E-value
SCGB3A pfam20490
Secretoglobin 3A; This family includes secretoglobin family 3A member 1 (SCGB3A1) and member 2 ...
 20-85 3.54e-29

Secretoglobin 3A; This family includes secretoglobin family 3A member 1 (SCGB3A1) and member 2 (SCGB3A2), also known as uteroglobin-related proteins. They are a small secreted proteins expressed in airway epithelial cells. SCGB3A2, also known as UGRP1, has an important anti-inflammatory activity and is involved in asthma. SCGB3A2 mediates its anti-inflammatory action through inhibition of ERK and JNK activation. It is also involved in lung development and has anti-fibrotic activity in lung.


Pssm-ID: 466639  Cd Length: 68  Bit Score: 100.00  E-value: 3.54e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 576067743   20 TALLINRL--PVVDKLPVPLDDIIPSFDPLKMLLKTLGISVEHLVTGLKKCVDELGPEASEAVKKLLV 85
Cdd:pfam20490   1 AAFFVNSVakPVAALAPLPLDSILPFFNPLKLLLTSLGIPVEHLVEGSRKCVAELGPEAVEAVKKLLG 68
Uteroglobin pfam01099
Uteroglobin family; Uteroglobin is a homodimer of two identical 70 amino acid polypeptides ...
 1-92 7.40e-03

Uteroglobin family; Uteroglobin is a homodimer of two identical 70 amino acid polypeptides linked by two disulphide bridges. The precise role of uteroglobin has still to be elucidated.


Pssm-ID: 460063  Cd Length: 90  Bit Score: 32.95  E-value: 7.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576067743    1 MKLVSIFLLVTIGICGYSATAllinrlpvvdklpvpldDIIPSFDplKMLLKTLGISVEHLV----------------TG 64
Cdd:pfam01099   1 MKLSVALLLVTLALCCYAGSA-----------------DGCPALE--EVVEKFLFGSEEEYKeslekynpppeaveakLE 61

                          90       100
                  ....*....|....*....|....*...
gi 576067743   65 LKKCVDELGPEASEAVKKLLVIIICSYF 92
Cdd:pfam01099  62 LKQCFDKLSNETRLNIAKLLEKILLSPL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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