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Conserved domains on  [gi|586798134|ref|NP_001276975|]
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chromatin remodeling regulator CECR2 isoform 2 [Homo sapiens]

Protein Classification

bromodomain-containing protein( domain architecture ID 10144732)

bromodomain-containing protein may act as transcription regulator involved in chromatin-based DNA damage response (DDR) pathways, which maintain genome integrity from cell-intrinsic and extrinsic DNA-damaging sources

CATH:  1.20.920.10
Gene Ontology:  GO:0005515
PubMed:  31582847|28847823|34548613|1350857|26472704

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 255-355 3.71e-56

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 189.30  E-value: 3.71e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  255 DDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGES 334
Cdd:cd05509     1 PLYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPD 80

                          90       100
                  ....*....|....*....|.
gi 586798134  335 SEYTKMSDNLERCFHRAMMKH 355
Cdd:cd05509    81 TEYYKCANKLEKFFWKKLKEL 101
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 382-864 3.38e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.88  E-value: 3.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  382 AGRSGGSHVWTRSRDPEGSSRKQQPMENGGKSLPPTRRAPSSGDDQSSSSTQPPREVGTSngRGFSHPlhcGGTPSQAPF 461
Cdd:PHA03247 2574 APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSP--AANEPD---PHPPPTVPP 2648

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  462 LNQMR--PAVPGTFGPLRGSDPATlygssgvpEPHPGEPVQQRQPFTMQPPVG-INSLRGPrlgTPEEKQMCGGLTHLSN 538
Cdd:PHA03247 2649 PERPRddPAPGRVSRPRRARRLGR--------AAQASSPPQRPRRRAARPTVGsLTSLADP---PPPPPTPEPAPHALVS 2717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  539 MGPHPGSLQLGQISGPSQDGSMYAPAQFQPGFIP--PRHGGAPARP--PDFPESSEIPPSHMYRsykylnRVHSAVWNGN 614
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTagPPAPAPPAAPAAGPPR------RLTRPAVASL 2791

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  615 HGATNQGPLGPDEKPHLGPGPSHQPRTLGHVMDSRVMRPP--VPPNQWTEQSGFLPHGVPSSGYMRP--PCKSAGHRLQP 690
Cdd:PHA03247 2792 SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPtsAQPTAPPPPPGPPPPSLPLGGSVAPggDVRRRPPSRSP 2871

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  691 PPVPAPSSLFGAPAQALRGVQggdsmmdspemiamQQLSSRVCPPGVPYHPHQPAHPRLPGPFPQVAHPMSVTVSAPKPA 770
Cdd:PHA03247 2872 AAKPAAPARPPVRRLARPAVS--------------RSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  771 LGNPGRAPENSEAQEPE-NDQEPLPGLEEKPPGvgtSEGVYLTQLPHPTPPLQTDCTRQSSPQERETVGPELKSSS---S 846
Cdd:PHA03247 2938 RPQPPLAPTTDPAGAGEpSGAVPQPWLGALVPG---RVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSlalH 3014

                         490
                  ....*....|....*...
gi 586798134  847 ESADNCKAMKGKNPWPSD 864
Cdd:PHA03247 3015 EETDPPPVSLKQTLWPPD 3032
 
Name Accession Description Interval E-value
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 255-355 3.71e-56

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 189.30  E-value: 3.71e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  255 DDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGES 334
Cdd:cd05509     1 PLYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPD 80

                          90       100
                  ....*....|....*....|.
gi 586798134  335 SEYTKMSDNLERCFHRAMMKH 355
Cdd:cd05509    81 TEYYKCANKLEKFFWKKLKEL 101
BROMO smart00297
bromo domain;
255-348 3.79e-32

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 121.23  E-value: 3.79e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134    255 DDFTAMYKVLDVVKAHKD----SWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKY 330
Cdd:smart00297    3 KLQKKLQELLKAVLDKLDshplSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTY 82

                            90
                    ....*....|....*...
gi 586798134    331 NGESSEYTKMSDNLERCF 348
Cdd:smart00297   83 NGPDSEVYKDAKKLEKFF 100
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 233-415 9.50e-27

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 113.75  E-value: 9.50e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  233 SHLDPNSPMREEKKTKDLFELDDDFTAMY--KVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLY 310
Cdd:COG5076   124 AHLKTSVKKRKTPKIEDELLYADNKAIAKfkKQLFLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRY 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  311 CTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLErcfhRAMMKHFPGEDGDTDEEFWIREDEKREKRRS--------RA 382
Cdd:COG5076   204 KSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELE----KYFLKLIEEIPEEMLELSIKPGREEREERESvlitnsqaHV 279

                         170       180       190
                  ....*....|....*....|....*....|...
gi 586798134  383 GRSGGSHVWTRSRDPEGSSRKQQPMENGGKSLP 415
Cdd:COG5076   280 GAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELK 312
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 262-342 3.44e-22

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 91.61  E-value: 3.44e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134   262 KVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMS 341
Cdd:pfam00439    3 EILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAA 82


                   .
gi 586798134   342 D 342
Cdd:pfam00439   83 E 83
PHA03247 PHA03247
large tegument protein UL36; Provisional
 382-864 3.38e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.88  E-value: 3.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  382 AGRSGGSHVWTRSRDPEGSSRKQQPMENGGKSLPPTRRAPSSGDDQSSSSTQPPREVGTSngRGFSHPlhcGGTPSQAPF 461
Cdd:PHA03247 2574 APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSP--AANEPD---PHPPPTVPP 2648

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  462 LNQMR--PAVPGTFGPLRGSDPATlygssgvpEPHPGEPVQQRQPFTMQPPVG-INSLRGPrlgTPEEKQMCGGLTHLSN 538
Cdd:PHA03247 2649 PERPRddPAPGRVSRPRRARRLGR--------AAQASSPPQRPRRRAARPTVGsLTSLADP---PPPPPTPEPAPHALVS 2717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  539 MGPHPGSLQLGQISGPSQDGSMYAPAQFQPGFIP--PRHGGAPARP--PDFPESSEIPPSHMYRsykylnRVHSAVWNGN 614
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTagPPAPAPPAAPAAGPPR------RLTRPAVASL 2791

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  615 HGATNQGPLGPDEKPHLGPGPSHQPRTLGHVMDSRVMRPP--VPPNQWTEQSGFLPHGVPSSGYMRP--PCKSAGHRLQP 690
Cdd:PHA03247 2792 SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPtsAQPTAPPPPPGPPPPSLPLGGSVAPggDVRRRPPSRSP 2871

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  691 PPVPAPSSLFGAPAQALRGVQggdsmmdspemiamQQLSSRVCPPGVPYHPHQPAHPRLPGPFPQVAHPMSVTVSAPKPA 770
Cdd:PHA03247 2872 AAKPAAPARPPVRRLARPAVS--------------RSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  771 LGNPGRAPENSEAQEPE-NDQEPLPGLEEKPPGvgtSEGVYLTQLPHPTPPLQTDCTRQSSPQERETVGPELKSSS---S 846
Cdd:PHA03247 2938 RPQPPLAPTTDPAGAGEpSGAVPQPWLGALVPG---RVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSlalH 3014

                         490
                  ....*....|....*...
gi 586798134  847 ESADNCKAMKGKNPWPSD 864
Cdd:PHA03247 3015 EETDPPPVSLKQTLWPPD 3032
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 579-759 1.09e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.57  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134   579 PARPPDFPESSEIPPSHMYRSYKY--LNRVHSAVWNGNHGATNQGPLGPDEKPHLGPGPSHQPRTLGHVMDSRVMRPPVP 656
Cdd:pfam09770  170 AAAPAPAPQPAAQPASLPAPSRKMmsLEEVEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQ 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134   657 PNQwteQSGFLPHGVPSSGYMRPPCKSAghrlQPPPVPAPSSLFGAPAQALRGVQGGDSMMDSPEMIAMQQLSSRVCPP- 735
Cdd:pfam09770  250 PQQ---PQQHPGQGHPVTILQRPQSPQP----DPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQp 322

                          170       180
                   ....*....|....*....|....*..
gi 586798134   736 ---GVPYHPHQPAHPRLPGPFPQVAHP 759
Cdd:pfam09770  323 gvqPAPAHQAHRQQGSFGRQAPIITHP 349
 
Name Accession Description Interval E-value
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 255-355 3.71e-56

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 189.30  E-value: 3.71e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  255 DDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGES 334
Cdd:cd05509     1 PLYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPD 80

                          90       100
                  ....*....|....*....|.
gi 586798134  335 SEYTKMSDNLERCFHRAMMKH 355
Cdd:cd05509    81 TEYYKCANKLEKFFWKKLKEL 101
BROMO smart00297
bromo domain;
255-348 3.79e-32

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 121.23  E-value: 3.79e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134    255 DDFTAMYKVLDVVKAHKD----SWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKY 330
Cdd:smart00297    3 KLQKKLQELLKAVLDKLDshplSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTY 82

                            90
                    ....*....|....*...
gi 586798134    331 NGESSEYTKMSDNLERCF 348
Cdd:smart00297   83 NGPDSEVYKDAKKLEKFF 100
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 259-352 3.47e-31

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 117.86  E-value: 3.47e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  259 AMYKVLDVVKAH--KDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSE 336
Cdd:cd04369     4 KLRSLLDALKKLkrDLSEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSP 83

                          90
                  ....*....|....*.
gi 586798134  337 YTKMSDNLERCFHRAM 352
Cdd:cd04369    84 IYKDAKKLEKLFEKLL 99
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 233-415 9.50e-27

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 113.75  E-value: 9.50e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  233 SHLDPNSPMREEKKTKDLFELDDDFTAMY--KVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLY 310
Cdd:COG5076   124 AHLKTSVKKRKTPKIEDELLYADNKAIAKfkKQLFLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRY 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  311 CTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLErcfhRAMMKHFPGEDGDTDEEFWIREDEKREKRRS--------RA 382
Cdd:COG5076   204 KSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELE----KYFLKLIEEIPEEMLELSIKPGREEREERESvlitnsqaHV 279

                         170       180       190
                  ....*....|....*....|....*....|...
gi 586798134  383 GRSGGSHVWTRSRDPEGSSRKQQPMENGGKSLP 415
Cdd:COG5076   280 GAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELK 312
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 267-352 1.05e-26

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 105.47  E-value: 1.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  267 VKAHKDSWPFLEPVD--ESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNL 344
Cdd:cd05500    16 LKRLKDARPFLVPVDpvKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNGPEHPVSQMGKRL 95


                  ....*...
gi 586798134  345 ERCFHRAM 352
Cdd:cd05500    96 QAAFEKHL 103
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 259-349 7.37e-25

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 100.55  E-value: 7.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  259 AMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYT 338
Cdd:cd05504    16 ALEQLLVEIVKHKDSWPFLRPVSKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNPEHTSVY 95

                          90
                  ....*....|.
gi 586798134  339 KMSDNLERCFH 349
Cdd:cd05504    96 KAGTRLQRFFI 106
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 262-352 2.27e-24

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 98.51  E-value: 2.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  262 KVLDVVKAHKDS---WPFLEPVDESY--APNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSE 336
Cdd:cd05499     7 EVLKELMKPKHSaynWPFLDPVDPVAlnIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFNPEGTD 86

                          90
                  ....*....|....*.
gi 586798134  337 YTKMSDNLERCFHRAM 352
Cdd:cd05499    87 VYMMGHQLEEVFNDKW 102
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 272-357 2.06e-23

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 96.18  E-value: 2.06e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  272 DSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDN-LERCfhR 350
Cdd:cd05511    17 DSWPFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSVYTKKAKEmLELA--E 94


                  ....*..
gi 586798134  351 AMMKHFP 357
Cdd:cd05511    95 ELLAERE 101
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 263-348 7.69e-23

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 93.98  E-value: 7.69e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  263 VLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSD 342
Cdd:cd05503     8 ILDEMEAHEDAWPFLEPVNTKLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDDSEVGRAGH 87


                  ....*.
gi 586798134  343 NLERCF 348
Cdd:cd05503    88 NMRKFF 93
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 270-357 1.53e-22

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 93.89  E-value: 1.53e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  270 HKDSWPFLEPVDESyAPNYYQIIKAPMDISSMEKKL---NGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLER 346
Cdd:cd05502    19 HELSLPFHEPVSPS-VPNYYKIIKTPMDLSLIRKKLqpkSPQHYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKELEL 97

                          90
                  ....*....|.
gi 586798134  347 CFHRAMMKHFP 357
Cdd:cd05502    98 FFEEQLKEILP 108
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 262-342 3.44e-22

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 91.61  E-value: 3.44e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134   262 KVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMS 341
Cdd:pfam00439    3 EILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAA 82


                   .
gi 586798134   342 D 342
Cdd:pfam00439   83 E 83
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 274-348 7.57e-21

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 88.49  E-value: 7.57e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 586798134  274 WPFLEPVDESY--APNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCF 348
Cdd:cd05498    22 WPFYKPVDPEAlgLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYNPPDHPVHAMARKLQDVF 98
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 259-335 9.40e-20

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 85.96  E-value: 9.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  259 AMYKVLDVV----KAH-KDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGE 333
Cdd:cd05510     7 EFYESLDKVlnelKTYtEHSTPFLTKVSKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNSD 86


                  ..
gi 586798134  334 SS 335
Cdd:cd05510    87 PS 88
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 266-349 1.06e-19

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 85.55  E-value: 1.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  266 VVKA---HKDSWPFLEPVDESY--APNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKM 340
Cdd:cd05497    13 VLKAlwkHKFAWPFQQPVDAVKlnLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGDDVVLM 92


                  ....*....
gi 586798134  341 SDNLERCFH 349
Cdd:cd05497    93 AQTLEKLFL 101
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 256-348 3.05e-17

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 78.35  E-value: 3.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  256 DFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESS 335
Cdd:cd05505     1 ELQKCEEILSKILKYRFSWPFREPVTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYENGS 80

                          90
                  ....*....|...
gi 586798134  336 EYTKMSDNLERCF 348
Cdd:cd05505    81 YVLSCMRKTEQCC 93
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 262-348 5.47e-16

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 74.67  E-value: 5.47e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  262 KVLDVVKAHKDSWPFLEPVDESY--APNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTK 339
Cdd:cd05506     7 TLLRKLMKHKWGWVFNAPVDVVAlgLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPPGNDVHT 86


                  ....*....
gi 586798134  340 MSDNLERCF 348
Cdd:cd05506    87 MAKELLKIF 95
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 286-346 4.28e-15

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 72.09  E-value: 4.28e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 586798134  286 PNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLER 346
Cdd:cd05518    37 PDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVYEDANILEK 97
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 263-352 6.10e-15

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 72.09  E-value: 6.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  263 VLDVVKAHKDSWPFLEPVDESY--APNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKM 340
Cdd:cd05495    12 LEKLYKQDPESLPFRQPVDPKLlgIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRKTSRVYKY 91

                          90
                  ....*....|..
gi 586798134  341 SDNLERCFHRAM 352
Cdd:cd05495    92 CTKLAEVFEQEI 103
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 262-354 2.41e-14

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 70.12  E-value: 2.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  262 KVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSeytkms 341
Cdd:cd05512     8 KTLDQLQEKDTAEIFSEPVDLSEVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKDT------ 81

                          90
                  ....*....|...
gi 586798134  342 dnlerCFHRAMMK 354
Cdd:cd05512    82 -----IFYRAAVR 89
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 262-331 2.33e-13

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 67.87  E-value: 2.33e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  262 KVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYN 331
Cdd:cd05496    12 ELVNLMWDCEDSEPFRQPVDLLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYT 81
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 260-354 3.14e-13

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 67.07  E-value: 3.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  260 MYKVLDVVKAHKD------SWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGE 333
Cdd:cd05516     6 MNKIVDVVIKYKDsdgrqlAEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLE 85

                          90       100
                  ....*....|....*....|.
gi 586798134  334 SSEYTKMSDNLERCFHRAMMK 354
Cdd:cd05516    86 GSLIYEDSIVLQSVFKSARQK 106
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 281-350 7.75e-13

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 65.72  E-value: 7.75e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  281 DESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHR 350
Cdd:cd05522    33 DKAREPEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQEYKDAVLLEKEARL 102
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 276-344 1.06e-12

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 65.12  E-value: 1.06e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 586798134  276 FLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNL 344
Cdd:cd05513    22 FAFPVTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPDTIYYKAAKKL 90
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 259-347 1.49e-12

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 65.08  E-value: 1.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  259 AMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYT 338
Cdd:cd05507     7 AILLVYRTLASHRYASVFLKPVTEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVY 86


                  ....*....
gi 586798134  339 KMSDNLERC 347
Cdd:cd05507    87 LMAVEMQRE 95
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 275-341 5.79e-12

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 63.53  E-value: 5.79e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 586798134  275 PFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMS 341
Cdd:cd05528    23 AFTKPVDEEEVPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNPDRDPADKLI 89
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 260-351 6.35e-12

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 63.48  E-value: 6.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  260 MYKVLDVVKAHKD------SWPFLE-PVDESYaPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNG 332
Cdd:cd05515     5 LWELYNAVKNYTDgrgrrlSLIFMRlPSKSEY-PDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNE 83

                          90
                  ....*....|....*....
gi 586798134  333 ESSEYTKMSDNLERCFHRA 351
Cdd:cd05515    84 PDSQIYKDALTLQKVLLET 102
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 275-341 6.58e-12

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 63.17  E-value: 6.58e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 586798134  275 PFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMS 341
Cdd:cd05508    22 PFLKPVDLEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGGDHKLTQAA 88
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 260-346 3.66e-11

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 61.20  E-value: 3.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  260 MYKVLDVVKAHKD------SWPFLE-PVDESYaPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNG 332
Cdd:cd05520     5 LWQLYDTIRNARNnqgqllAEPFLKlPSKRKY-PDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNV 83

                          90
                  ....*....|....
gi 586798134  333 ESSEYTKMSDNLER 346
Cdd:cd05520    84 PNSRIYKDAEKLQK 97
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 257-350 7.65e-11

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 60.81  E-value: 7.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  257 FTAMYKVLDVVKAHKDSwPFLEPVDE-SYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESS 335
Cdd:cd05529    30 ISGLDKLLLSLQLEIAE-YFEYPVDLrAWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAETFNEPNS 108

                          90
                  ....*....|....*
gi 586798134  336 EYTKMSDNLERCFHR 350
Cdd:cd05529   109 EIAKKAKRLSDWLLR 123
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 276-335 8.24e-10

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 57.35  E-value: 8.24e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  276 FLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESS 335
Cdd:cd05519    27 FLEKPSKKLYPDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGS 86
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 286-351 1.31e-09

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 56.63  E-value: 1.31e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 586798134  286 PNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRA 351
Cdd:cd05525    39 PDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGRKSPIGRDVCRLRKAYYQA 104
PHA03247 PHA03247
large tegument protein UL36; Provisional
 382-864 3.38e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.88  E-value: 3.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  382 AGRSGGSHVWTRSRDPEGSSRKQQPMENGGKSLPPTRRAPSSGDDQSSSSTQPPREVGTSngRGFSHPlhcGGTPSQAPF 461
Cdd:PHA03247 2574 APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSP--AANEPD---PHPPPTVPP 2648

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  462 LNQMR--PAVPGTFGPLRGSDPATlygssgvpEPHPGEPVQQRQPFTMQPPVG-INSLRGPrlgTPEEKQMCGGLTHLSN 538
Cdd:PHA03247 2649 PERPRddPAPGRVSRPRRARRLGR--------AAQASSPPQRPRRRAARPTVGsLTSLADP---PPPPPTPEPAPHALVS 2717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  539 MGPHPGSLQLGQISGPSQDGSMYAPAQFQPGFIP--PRHGGAPARP--PDFPESSEIPPSHMYRsykylnRVHSAVWNGN 614
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTagPPAPAPPAAPAAGPPR------RLTRPAVASL 2791

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  615 HGATNQGPLGPDEKPHLGPGPSHQPRTLGHVMDSRVMRPP--VPPNQWTEQSGFLPHGVPSSGYMRP--PCKSAGHRLQP 690
Cdd:PHA03247 2792 SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPtsAQPTAPPPPPGPPPPSLPLGGSVAPggDVRRRPPSRSP 2871

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  691 PPVPAPSSLFGAPAQALRGVQggdsmmdspemiamQQLSSRVCPPGVPYHPHQPAHPRLPGPFPQVAHPMSVTVSAPKPA 770
Cdd:PHA03247 2872 AAKPAAPARPPVRRLARPAVS--------------RSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  771 LGNPGRAPENSEAQEPE-NDQEPLPGLEEKPPGvgtSEGVYLTQLPHPTPPLQTDCTRQSSPQERETVGPELKSSS---S 846
Cdd:PHA03247 2938 RPQPPLAPTTDPAGAGEpSGAVPQPWLGALVPG---RVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSlalH 3014

                         490
                  ....*....|....*...
gi 586798134  847 ESADNCKAMKGKNPWPSD 864
Cdd:PHA03247 3015 EETDPPPVSLKQTLWPPD 3032
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 288-356 3.69e-09

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 55.51  E-value: 3.69e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 586798134  288 YYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGEsSEYTKMSDNLERCFHRAMMKHF 356
Cdd:cd05501    33 YCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFYKD-DDFGQVGITLEKKFEKNFKEVF 100
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 256-303 2.92e-07

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 50.13  E-value: 2.92e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 586798134  256 DFTAMYKVLDVVKAH---KDSWPFLEPVD--ESYAPNYYQIIKAPMDISSMEK 303
Cdd:cd05494     1 DYEALERVLRELKRHrrnEDAWPFLEPVNppRRGAPDYRDVIKRPMSFGTKVN 53
PHA03247 PHA03247
large tegument protein UL36; Provisional
 563-1028 6.75e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 6.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  563 PAQFQPGFIP---PRHGGAPARPPDFPESSEIPPSHMYRSYKYLNRVHSAVWNGNHG----ATNQG-----PLGPDEKPH 630
Cdd:PHA03247 2483 PAEARFPFAAgaaPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGleelASDDAgdpppPLPPAAPPA 2562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  631 LG----PGPSHQPRTLGHVMDSRVMRPPVPPNQWTEQSGFLPHGVPSSGYMRPPCKSAGHRLQPPPvPAPSSlfgapaQA 706
Cdd:PHA03247 2563 APdrsvPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPP-PSPSP------AA 2635

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  707 LRGVQGGDSMMDSPEMIAMQQLSSRVCPPGVPYHPHQPAHPRLP--GPFPQVAHPM--SVTVSA-PKPALGNPGRAPENS 781
Cdd:PHA03247 2636 NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPpqRPRRRAARPTvgSLTSLAdPPPPPPTPEPAPHAL 2715

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  782 EAQEP-------ENDQEPLPGLEEKPPGVGTSEGVYLTQLPHPTPPLQTDCTRQSSPqeRETVGPELKSSSSESADNCKA 854
Cdd:PHA03247 2716 VSATPlppgpaaARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP--AAPAAGPPRRLTRPAVASLSE 2793

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  855 MKGKNPWPSDSSYPGPAAQGCVRDLSTvadrgalsengvigEASPCGSEgkglgssgsekllcPRGRTLQETMPCTgQNA 934
Cdd:PHA03247 2794 SRESLPSPWDPADPPAAVLAPAAALPP--------------AASPAGPL--------------PPPTSAQPTAPPP-PPG 2844

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  935 ATPPSTDPG---LTGGTVSQFPPlymPGLEYPNSAAHYHISPGLQGVGPVMGGKSPASHPQHFPPRGFQsnhPHSGGFPR 1011
Cdd:PHA03247 2845 PPPPSLPLGgsvAPGGDVRRRPP---SRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQ---PQAPPPPQ 2918

                         490
                  ....*....|....*..
gi 586798134 1012 YRPPQGMRYSYHPPPQP 1028
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPP 2935
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 279-347 3.28e-06

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 46.93  E-value: 3.28e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 586798134  279 PVDESYaPNYYQIIKAPMDISSMEKKLNGglYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERC 347
Cdd:cd05521    32 PLRKDY-PDYYKIIKNPLSLNTVKKRLPH--YTNAQEFVNDLAQIPWNARLYNTKGSVIYKYALILEKY 97
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 264-349 6.06e-06

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 50.19  E-value: 6.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  264 LDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYtKMSDN 343
Cdd:COG5076   272 ITNSQAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELKLRNNYYRPEETFVRDAKLFFDNCVMYNGEVTDY-YKNAN 350


                  ....*.
gi 586798134  344 LERCFH 349
Cdd:COG5076   351 VLEDFV 356
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 286-360 2.86e-05

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 44.63  E-value: 2.86e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 586798134  286 PNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRK-YNGESSEYTKMSDnLERCFHRAMMKHFPGED 360
Cdd:cd05524    39 PEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAyYKPDSPEHKDACK-LWELFLSARNEVLSGGE 113
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 579-759 1.09e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.57  E-value: 1.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134   579 PARPPDFPESSEIPPSHMYRSYKY--LNRVHSAVWNGNHGATNQGPLGPDEKPHLGPGPSHQPRTLGHVMDSRVMRPPVP 656
Cdd:pfam09770  170 AAAPAPAPQPAAQPASLPAPSRKMmsLEEVEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQ 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134   657 PNQwteQSGFLPHGVPSSGYMRPPCKSAghrlQPPPVPAPSSLFGAPAQALRGVQGGDSMMDSPEMIAMQQLSSRVCPP- 735
Cdd:pfam09770  250 PQQ---PQQHPGQGHPVTILQRPQSPQP----DPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQp 322

                          170       180
                   ....*....|....*....|....*..
gi 586798134   736 ---GVPYHPHQPAHPRLPGPFPQVAHP 759
Cdd:pfam09770  323 gvqPAPAHQAHRQQGSFGRQAPIITHP 349
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 286-348 3.55e-04

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 41.27  E-value: 3.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 586798134  286 PNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCF 348
Cdd:cd05517    37 PDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVYKDANAIKKIF 99
Bromo_TBP7_like cd05491
Bromodomain; TBP7_like subfamily, limited to fungi. TBP7, or TAT-binding protein homolog 7, is ...
 296-329 1.90e-03

Bromodomain; TBP7_like subfamily, limited to fungi. TBP7, or TAT-binding protein homolog 7, is a yeast protein of unknown function that contains AAA-superfamily ATP-ase domains and a bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99923  Cd Length: 119  Bit Score: 39.36  E-value: 1.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 586798134  296 MDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRK 329
Cdd:cd05491    65 MDLDTIEERLWNGYYATPKDFLKDIKRIVRDAKT 98
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 458-791 2.15e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 42.30  E-value: 2.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134   458 QAPFLNQMRPavPGTFGPLRGSDPATLYGSSGVPEPHPGEPVQQRQPFTMQPPVGINSLRGPRLGTPEEKQMCGGLTHLS 537
Cdd:pfam09606  107 GGPMGQQMGG--PGTASNLLASLGRPQMPMGGAGFPSQMSRVGRMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQ 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134   538 NMGPHPGSLQLGQISGPSQ------------DGSMYAPAQFQPGFIPPRHGGAPARPP--DFPESSEIPPSHMYRSYKYL 603
Cdd:pfam09606  185 AGGMNGGQQGPMGGQMPPQmgvpgmpgpadaGAQMGQQAQANGGMNPQQMGGAPNQVAmqQQQPQQQGQQSQLGMGINQM 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134   604 NRVHSAVWNG-NHGATNQGPLGPDEKPHL--------GPGPSHQPRTLGHVMDSRVMRPPVPPNQWTEQSGFLPHGVPSS 674
Cdd:pfam09606  265 QQMPQGVGGGaGQGGPGQPMGPPGQQPGAmpnvmsigDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALG 344

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134   675 GYMRPPCKSAGHRL---QPPPVPAPSSLFG----APAQALRGVQGGDSMMDSPemiamQQLSSRVCPPGV---PYHPHQP 744
Cdd:pfam09606  345 GLNHLETWNPGNFGglgANPMQRGQPGMMSspspVPGQQVRQVTPNQFMRQSP-----QPSVPSPQGPGSqppQSHPGGM 419

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 586798134   745 AHP--RLPGPFPQVAHPMSVTVSAPKPALGNPGRAPENSEAQEPENDQE 791
Cdd:pfam09606  420 IPSpaLIPSPSPQMSQQPAQQRTIGQDSPGGSLNTPGQSAVNSPLNPQE 468
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 484-902 5.84e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 5.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  484 LYGSSG--VPEPHPGE---PVQQRQPFTMQPPVGiNSLRGPRLGTPEEKQMCGGLTHLSNMGPHPGSlQLGQISGPSQDG 558
Cdd:PHA03307   36 LSGSQGqlVSDSAELAavtVVAGAAACDRFEPPT-GPPPGPGTEAPANESRSTPTWSLSTLAPASPA-REGSPTPPGPSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  559 SMYAPAQFQPGFIPPRHggAPARPPDFPESSEIPPshmyrsykylnrvhsavwnGNHGATNQGPLGPDEKPHLGPGPSHQ 638
Cdd:PHA03307  114 PDPPPPTPPPASPPPSP--APDLSEMLRPVGSPGP-------------------PPAASPPAAGASPAAVASDAASSRQA 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  639 PRTLGhvMDSRVMRPPVPPnqwTEQSGFLPHGVPSSGYMRPPCKSAGH-RLQPPPVPAPSSLFGAPA--------QALRG 709
Cdd:PHA03307  173 ALPLS--SPEETARAPSSP---PAEPPPSTPPAAASPRPPRRSSPISAsASSPAPAPGRSAADDAGAsssdssssESSGC 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  710 VQGGDSMMDSPeMIAMQQLSSRVCPPGVPYHPHQPAHPRLPGPFPQVAHPMSVTVSAPKPALGNPGRAPENSEAQEPEND 789
Cdd:PHA03307  248 GWGPENECPLP-RPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSS 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  790 QEPLPGlEEKPPGVGTSEGVYLTQLPHPTPPlqTDCTRQSSPQERETVGPELKSSSSESAD----NCKAMKGKNPWPSDS 865
Cdd:PHA03307  327 SSTSSS-SESSRGAAVSPGPSPSRSPSPSRP--PPPADPSSPRKRPRPSRAPSSPAASAGRptrrRARAAVAGRARRRDA 403

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 586798134  866 SYPGPAAQGCVRDLSTVADRGALSENGVIGeaSPCGS 902
Cdd:PHA03307  404 TGRFPAGRPRPSPLDAGAASGAFYARYPLL--TPSGE 438
PHA03378 PHA03378
EBNA-3B; Provisional
 392-698 6.43e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  392 TRSRDPEGSSRKQQPMENGGKSLPPTRRAPSS-GDDQSSSSTQPPREVGTSNGRGFSHPLHCGGTPSQA-PFLNQMRPAV 469
Cdd:PHA03378  611 TQSHIPETSAPRQWPMPLRPIPMRPLRMQPITfNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTgANTMLPIQWA 690

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  470 PGTFGPlrgsdPATLYGSSGVPEPHPGEpvqqrqpftMQPPVGINSLRGPRLGTPEEKQmcgglthlsnmgphPGSLQLG 549
Cdd:PHA03378  691 PGTMQP-----PPRAPTPMRPPAAPPGR---------AQRPAAATGRARPPAAAPGRAR--------------PPAAAPG 742

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  550 QISGPSQDGSMYAPAQFQPGFIPPRhGGAPARPPDFPesseiPPshmyrsykylnrvhsavwngnhgatnQGPLGPDEKP 629
Cdd:PHA03378  743 RARPPAAAPGRARPPAAAPGRARPP-AAAPGAPTPQP-----PP--------------------------QAPPAPQQRP 790

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 586798134  630 HLGPGPSHQPRTLGHVMdsrVMRPPVPPNQWTEQSGFLPH---GVPSSGYMRPPCKSAGHRLQPP-PVPAPSS 698
Cdd:PHA03378  791 RGAPTPQPPPQAGPTSM---QLMPRAAPGQQGPTKQILRQlltGGVKRGRPSLKKPAALERQAAAgPTPSPGS 860
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 723-848 8.45e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 40.48  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586798134  723 IAMQQLSSRVCPPGVPY-HPHQPAHPRLPGPFPQvahPMSVTVSAPKPALgnpgrAPENSEAQEPENDQEPLPGLEEKP- 800
Cdd:PHA03269   12 IACINLIIANLNTNIPIpELHTSAATQKPDPAPA---PHQAASRAPDPAV-----APTSAASRKPDLAQAPTPAASEKFd 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 586798134  801 PGVGTSEGVylTQLPHPTPPLQTDCTRQSSPQERETVGPELKSSSSES 848
Cdd:PHA03269   84 PAPAPHQAA--SRAPDPAVAPQLAAAPKPDAAEAFTSAAQAHEAPADA 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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