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Conserved domains on  [gi|665389524|ref|NP_001284851|]
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Cap methyltransferase 1, isoform B [Drosophila melanogaster]

Protein Classification

cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1( domain architecture ID 10482028)

cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 is a class I SAM-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs

CATH:  2.20.25.110
EC:  2.1.1.57
Gene Ontology:  GO:0097309|GO:0004483|GO:1904047|GO:0008757
PubMed:  11051760|12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 172-383 2.31e-38

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


:

Pssm-ID: 426399  Cd Length: 179  Bit Score: 140.80  E-value: 2.31e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389524  172 FLNRAAVKMANIDSMCNFMftnprdPAGQTLVapdellyftDMCAGPGGFSEYVLYRKswEAKGFGFTLRGANDFKLEKF 251
Cdd:pfam01728   1 YRSRAAYKLLEIDEKFGLL------KPGKTVL---------DLGAAPGGWSQVALQRG--AGKVVGVDLGPMQLWKPRND 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389524  252 faaspeSFDTFYGvkedGNIFDESNQDslneYIRMHTPQGVHFAMADGGFSVEGQKNIQEILSKQLYLCQFLTALKILRP 331
Cdd:pfam01728  64 ------PGVTFIQ----GDIRDPETLD----LLEELLGRKVDLVLSDGSPFISGNKVLDHLRSLDLVKAALEVALELLRK 129

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 665389524  332 NGSFVCKVFDlFTPFSvGLVYLMYKCFQQIAIIKPNSSRPANSERYLVCKYK 383
Cdd:pfam01728 130 GGNFVCKVFQ-GEDFS-ELLYLLKLGFEKVGVFKPPASRPESSEEYLVCLGF 179
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 25-69 4.31e-15

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


:

Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 69.84  E-value: 4.31e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 665389524   25 YSNKAMEMMKKMGYENDKGLGKSNQGRLEPIIAVQQDGRRGFGLK 69
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
 
Name Accession Description Interval E-value
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 172-383 2.31e-38

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 140.80  E-value: 2.31e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389524  172 FLNRAAVKMANIDSMCNFMftnprdPAGQTLVapdellyftDMCAGPGGFSEYVLYRKswEAKGFGFTLRGANDFKLEKF 251
Cdd:pfam01728   1 YRSRAAYKLLEIDEKFGLL------KPGKTVL---------DLGAAPGGWSQVALQRG--AGKVVGVDLGPMQLWKPRND 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389524  252 faaspeSFDTFYGvkedGNIFDESNQDslneYIRMHTPQGVHFAMADGGFSVEGQKNIQEILSKQLYLCQFLTALKILRP 331
Cdd:pfam01728  64 ------PGVTFIQ----GDIRDPETLD----LLEELLGRKVDLVLSDGSPFISGNKVLDHLRSLDLVKAALEVALELLRK 129

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 665389524  332 NGSFVCKVFDlFTPFSvGLVYLMYKCFQQIAIIKPNSSRPANSERYLVCKYK 383
Cdd:pfam01728 130 GGNFVCKVFQ-GEDFS-ELLYLLKLGFEKVGVFKPPASRPESSEEYLVCLGF 179
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 25-69 4.31e-15

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 69.84  E-value: 4.31e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 665389524   25 YSNKAMEMMKKMGYENDKGLGKSNQGRLEPIIAVQQDGRRGFGLK 69
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 24-67 1.99e-11

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 59.48  E-value: 1.99e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 665389524    24 SYSNKAMEMMKKMGYENDKGLGKSNQGRLEPIIAVQQDGRRGFG 67
Cdd:smart00443   2 STSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLG 45
RlmE COG0293
23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and ...
 315-384 3.14e-11

23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440062 [Multi-domain]  Cd Length: 208  Bit Score: 63.55  E-value: 3.14e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665389524 315 KQLYLC----QFltALKILRPNGSFVCKVF--DLFTPFsvglVYLMYKCFQQIAIIKPNSSRPANSERYLVCKYKR 384
Cdd:COG0293  138 RSMYLVelalDF--ARKVLKPGGAFVVKVFqgEGFDEL----LKELKKLFKKVKHRKPKASRARSSEVYLVAKGFK 207
 
Name Accession Description Interval E-value
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 172-383 2.31e-38

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 140.80  E-value: 2.31e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389524  172 FLNRAAVKMANIDSMCNFMftnprdPAGQTLVapdellyftDMCAGPGGFSEYVLYRKswEAKGFGFTLRGANDFKLEKF 251
Cdd:pfam01728   1 YRSRAAYKLLEIDEKFGLL------KPGKTVL---------DLGAAPGGWSQVALQRG--AGKVVGVDLGPMQLWKPRND 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389524  252 faaspeSFDTFYGvkedGNIFDESNQDslneYIRMHTPQGVHFAMADGGFSVEGQKNIQEILSKQLYLCQFLTALKILRP 331
Cdd:pfam01728  64 ------PGVTFIQ----GDIRDPETLD----LLEELLGRKVDLVLSDGSPFISGNKVLDHLRSLDLVKAALEVALELLRK 129

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 665389524  332 NGSFVCKVFDlFTPFSvGLVYLMYKCFQQIAIIKPNSSRPANSERYLVCKYK 383
Cdd:pfam01728 130 GGNFVCKVFQ-GEDFS-ELLYLLKLGFEKVGVFKPPASRPESSEEYLVCLGF 179
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 25-69 4.31e-15

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 69.84  E-value: 4.31e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 665389524   25 YSNKAMEMMKKMGYENDKGLGKSNQGRLEPIIAVQQDGRRGFGLK 69
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 24-67 1.99e-11

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 59.48  E-value: 1.99e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 665389524    24 SYSNKAMEMMKKMGYENDKGLGKSNQGRLEPIIAVQQDGRRGFG 67
Cdd:smart00443   2 STSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLG 45
RlmE COG0293
23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and ...
 315-384 3.14e-11

23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440062 [Multi-domain]  Cd Length: 208  Bit Score: 63.55  E-value: 3.14e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665389524 315 KQLYLC----QFltALKILRPNGSFVCKVF--DLFTPFsvglVYLMYKCFQQIAIIKPNSSRPANSERYLVCKYKR 384
Cdd:COG0293  138 RSMYLVelalDF--ARKVLKPGGAFVVKVFqgEGFDEL----LKELKKLFKKVKHRKPKASRARSSEVYLVAKGFK 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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