|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
33-1257 |
0e+00 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 1079.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 33 CVWYGVCNTNDFSHSQNCPYNGTAKEMATDGLELLKKRCGFLLENSENKFCCDKNQVELLNKNVELAGNILDRCPSCMEN 112
Cdd:TIGR00917 1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLCQYSHPTISGNVCCTETQFDTLRSNVQQAIPFIVRCPACLRN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 113 LVRHICQFTCSPKQAEFMHVVATQKNKKGDEyISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGaYSASRCNPT 192
Cdd:TIGR00917 81 FLNLFCELTCSPDQSLFINVTSTTKVKTNST-VDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGG-GAKNFKEWF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 193 KWFNFMGDATNPYVPFQITYIqHEPKSNSNNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCPQGPPEPPRPEPFKIVGL 272
Cdd:TIGR00917 159 NWIGQKAGVNLPGAPYGIAFL-PTPCPVSSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSIKLGV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 273 DAYFVIMAAVFLVGVLVFLMGSFLFTqdDNFQVDGNDVSDEMPYSENDSYF------------EKLGAHTETFLETFFTK 340
Cdd:TIGR00917 238 KCVDFILAILYIVLVSVFLGGGLLHP--VRGKKKTSQMGTLSEADGEINSVnqqkdqntpqrnWGQLSTVQGHLARFFGK 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 341 WGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVhn 420
Cdd:TIGR00917 316 YGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIATVQTSSHE-- 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 421 tsngpyTFGPVFDREFLTKVLDLQEGIKEINAN----GTQLKDICYAPLSDdgseidvSQCVVQSIWGYFGDDRERLDDH 496
Cdd:TIGR00917 394 ------KAPEILTDDNLKLLFDIQKKVSQLFANyegeLITLDSPCFKPNHP-------YNCFIYSTCKKLQNMYSKLKPE 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 497 DEDNGFNVTYLDALYDCISNPYLCLAPYGGPVDPAIALGGFlppgdqltGSTKFELANAIILTFLVKNHHNKTD-LENAL 575
Cdd:TIGR00917 461 NYDDYGGVDYVKYCFEHFTSPESCLSAFGGPVDPTTVLGGF--------SGNNFSEASAFVVTFPVNNFVNKTNkTEKAV 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 576 TWEKKFVEFMTNYtKNNMSQYmDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLG 655
Cdd:TIGR00917 533 AWEKAFIQLAKDE-LLPMVQA-TISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLG 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 656 IGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNE---------TLEQQVGRIL 726
Cdd:TIGR00917 611 LSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQvgvdneqelTLERRLSRAL 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 727 GKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKKPD- 805
Cdd:TIGR00917 691 MEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSi 770
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 806 -----SITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENL 880
Cdd:TIGR00917 771 saekgSGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLL 850
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 881 NIGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIylasrhSNQTYIARPASSWIDDYFDWAAAASSCCKYRKDS 960
Cdd:TIGR00917 851 EVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNVF------NNLSYIAKPASSWLDDYLVWLSPQASCCCRKFTN 924
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 961 GDFCPHQDTSCLRC-NITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSNSHERlnIEASYFMAYHTI 1039
Cdd:TIGR00917 925 GTFCNGPDPQCFRCaDLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQGYATI--IQASSFRTYHTP 1002
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1040 LKSSADYFLALESARKISANITQmlqgrlmsngvpmasALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTF 1119
Cdd:TIGR00917 1003 LNTQVDFINAMRAAQEFAAKVSR---------------SSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCL 1067
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1120 VLMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKM 1199
Cdd:TIGR00917 1068 FLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGM 1147
|
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|....*...
gi 665407388 1200 GSSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIG 1257
Cdd:TIGR00917 1148 GSSVFSGITLTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
|
|
| NPC1_N |
pfam16414 |
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ... |
31-256 |
2.23e-99 |
|
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.
Pssm-ID: 465110 Cd Length: 239 Bit Score: 316.47 E-value: 2.23e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 31 QDCVWYGVCNTND-FSHSQNCPYNGTAKEMATDGLELLKKRCGFLLENsENKFCCDKNQVELLNKNVELAGNILDRCPSC 109
Cdd:pfam16414 1 GRCAWYGECGKKSlFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFAD-ETPVCCDADQLNTLRSNLKLAEGLLSRCPAC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 110 MENLVRHICQFTCSPKQAEFMHVVATQKNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYsasrC 189
Cdd:pfam16414 80 KKNFANLFCEFTCSPNQSTFLNVTKTKKSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICGGA----C 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665407388 190 NPTKWFNFMGDATNPYVPFQITYIQhEPKSNSNNFTPLNVTTVPCNQAVSSKlPACSCSDCDLSCPQ 256
Cdd:pfam16414 156 NYTRWLKFMGDKKNGGSPFQINFPD-PPEEDPSGMVPLNPNTKDCNESYDAS-YACSCVDCPLSCPP 220
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
534-1254 |
3.37e-68 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 246.50 E-value: 3.37e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 534 LGGFLPP---GDQLTGSTKFELANAIILTFLVKNHHNKTDlENALTWEKKFVEFMTNYTKnnmSQYMDIAFTSERSIEDE 610
Cdd:pfam02460 132 TPIYLGPhfgGVDFEPPGNISYAKAIVLWYFLKFDEEEVE-EDSKEWEDELSQLLHNKYA---SEHIQFTIFHDQILNDE 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 611 LNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATlIIVEVIPF 690
Cdd:pfam02460 208 LVRNALTLTPFFVIGFFLLLTFSIIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFN-SIVCVTPF 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 691 LVLAVGVDNIFILVQTHQRDQRKpnETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDF 770
Cdd:pfam02460 287 LVLAIGVDDMFLMVAAWQRTTAT--LSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDF 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 771 LLQITCFVSLFTLDTKRREENRMdiCCFIKGKKPDSITSNEG-----------LLYKFFSSVYVPFLMKKIVRASVMVIF 839
Cdd:pfam02460 365 IYQITFFAAIMAICAKPEAEGRH--CLFVWATSSPQRIDSEGsepdkshnieqLKSRFFLDIYCPFLLNPSVRVCMLVLF 442
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 840 FAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENL-NIGPPVYFVLK--GDLayTNSSdqnlvcagqycNDDSV 916
Cdd:pfam02460 443 VVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHFwPEGLQIQVAVNnpPNL--TIPE-----------SRDRM 509
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 917 LTqiyLASRHSNQTYIARPASS--WIDDYFDWaaaasscckyrkdsgdfcphqdtsclRCNITKNSLLRPEEKEFVKYLP 994
Cdd:pfam02460 510 NE---MVDEFENTPYSLGPNSTlfWLREYENF--------------------------LSTLNMEEEEDEEKEWSYGNLP 560
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 995 FFLKdnpddtcakaghaaYGGavrysNSHERLNIeasYFMAYHTILKSsadyFLALESARKIS--ANITQMLQG-RLMSN 1071
Cdd:pfam02460 561 SFLK--------------APG-----NSHWAGDL---VWDDNTTMVTK----FRFTLAGKGLStwNDRTRALQEwRSIAD 614
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1072 GVPMASALTvevfpYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGfdvHSALVVVITITMIVVNLG--GLMYY 1149
Cdd:pfam02460 615 QYPEFNVTV-----FDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIP---NPPCVFVITLAIASIDIGvfGFLSL 686
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1150 WNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSIFSGITLTkFAGILVLAFAKSQIFQVF 1229
Cdd:pfam02460 687 WGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLST-ILGVLVLLFVPSYMVVVF 765
|
730 740
....*....|....*....|....*
gi 665407388 1230 YFRMYLgIVVIGAAHGLIFLPVLLS 1254
Cdd:pfam02460 766 FKTVFL-VVAIGLLHGLFILPIILS 789
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
647-801 |
1.38e-65 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 218.61 E-value: 1.38e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 647 FIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNEtlEQQVGRIL 726
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDV--SERIAEAL 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665407388 727 GKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKG 801
Cdd:pfam12349 79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
577-1259 |
5.65e-59 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 222.45 E-value: 5.65e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 577 WEKKFVEFMTNYTKNNMSQYMdIAFTSErSIEDELNRESQSDVLTILVSYLIMFMYIAISLghvkeFKRVFIDSKITLGI 656
Cdd:TIGR00918 359 WQRNFSEEVQQSLPKNSSQKI-LVFSST-TLDDILKKFSDVSAIRIVSGYLLMLAYACLTM-----LRWDCAKSQGSVGL 431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 657 GGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILvqTHQRDQRKPNETLEQQVGRILGKVGPSMLLT 736
Cdd:TIGR00918 432 AGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLL--AHAFSETGQNIPFEERTGECLKRTGASVVLT 509
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 737 SLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDI-CCFIKG-------------- 801
Cdd:TIGR00918 510 SISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIfCCFFSPcsarviqiepqaya 589
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 802 -------------------------------------------------KKPDSITSNEGLLYKFFSSV----------- 821
Cdd:TIGR00918 590 dgsappvysshmqstvqlrteydpgtqhyyttneprshlsvqpsdplscQSPDIAGSTRDLLSQFEDSKaaclslpcarw 669
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 822 ---------YVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDS----FV---LHYFQSLNenlnigpp 885
Cdd:TIGR00918 670 tlatfaekhYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTnehdFLdaqFRYFSFYN-------- 741
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 886 VYFVLKGDLAYTNSSDqnlvcagqycnddsvltQIY-LASRHSNQTYIARPA------------SSW---IDDYFD--WA 947
Cdd:TIGR00918 742 MYAVTQGNFDYPTQQQ-----------------LLYdLHQSFSSVKYVLKEDngqlprmwlhyfRDWlqgLQKAFDedWR 804
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 948 AAASSCCKYRKDSGDFC---------PHQDTSCLRCNITKNSLLRPE----EKEFVKYLPFFLKDNPddtcakAGHAAYG 1014
Cdd:TIGR00918 805 DGRITKENYRNGSDDAVlaykllvqtGHRDKPVDKEQLTTQRLVNADgiinPNAFYIYLSAWVSNDP------VAYAASQ 878
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1015 GAVR----------YSNSHERLNIEASYFMAYHTI------LKSSADYFLALESARKISANITQMlqgrlmsnGVPmasa 1078
Cdd:TIGR00918 879 ANIYphppewlhdkNDYDPENLRIPAAEPLEYAQFpfylngLRETSQFVEAIEHVRAICNNYEGF--------GLP---- 946
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1079 ltveVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMgFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVS 1158
Cdd:TIGR00918 947 ----SYPSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLL-LNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIP 1021
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1159 LVNLVMAVGISVEFCSHLVHSFATSKSVSQIdRAADSLSKMGSSIFSGiTLTKFAGILVLAFAKSQiFQVFYFRMYLGIV 1238
Cdd:TIGR00918 1022 VVILIASVGIGVEFTVHIALGFLTAIGDRNR-RAVLALEHMFAPVLDG-ALSTLLGVLMLAGSEFD-FIVRYFFAVLAVL 1098
|
810 820
....*....|....*....|..
gi 665407388 1239 -VIGAAHGLIFLPVLLSYIGAP 1259
Cdd:TIGR00918 1099 tCLGVLNGLVLLPVLLSMFGPE 1120
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
335-1253 |
1.54e-38 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 155.40 E-value: 1.54e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 335 ETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKlWASPNSKSRLEREFFDTKFSPfyrLEQIIIkavnl 414
Cdd:COG1033 1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVV----- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 415 pqIVHNTSNgpytfgpVFDREFLTKVLDLQEGIKEI-NANGTQ-LKDICYAPLSDDGSEIDvsqcvvQSIWGYFGDDRER 492
Cdd:COG1033 72 --AVEGKDD-------IFTPETLEALRELTEELEEIpGVDSVTsLTNVRATEGTEDGLTVE------PLIPDELPASPEE 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 493 LDDHDEDNGFNVTYLDALYdcisnpylclapyggpvdpaialggflppgdqltgSTKFELAnAIILTFlvknhhnKTDLE 572
Cdd:COG1033 137 LAELREKVLSSPLYVGRLV-----------------------------------SPDGKAT-LIVVTL-------DPDPL 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 573 NALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTIL-VSYLIMFMYIAISLGHVKEfkrVFIdsk 651
Cdd:COG1033 174 SSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFpLALLLILLLLFLFFRSLRG---VLL--- 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 652 itlgigGVIIVLASVVSSVGVFGYIGLPATLIIVeVIPFLVLAVGVDN-IFILVqtHQRDQRKPNETLEQQVGRILGKVG 730
Cdd:COG1033 248 ------PLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLLLAIGIDYgIHLLN--RYREERRKGLDKREALREALRKLG 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 731 PSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLdTKRREEnrmdiccfiKGKKPDSITSN 810
Cdd:COG1033 319 PPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSL-LPRPKP---------KTRRLKKPPEL 388
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 811 EGLLYKFFSsvyvpFLMKKivRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVL 890
Cdd:COG1033 389 GRLLAKLAR-----FVLRR--PKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGGSDPLEVVV 461
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 891 KGDlaytnssdqnlvcAGQYCNDDSVLTQIYLASRH-SNQTYIARPASswIDDYFDWAAAAsscckYRKDSGDFcphqdt 969
Cdd:COG1033 462 DTG-------------EPDGLKDPEVLKEIDRLQDYlESLPEVGKVLS--LADLVKELNQA-----LNEGDPKY------ 515
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 970 sclrcnitkNSLlrPEEKEFVKYLPFFLKDNPDDTcakaghaayggAVRYSNS-HERLNIeaSYFMAYHtilkSSADYFL 1048
Cdd:COG1033 516 ---------YAL--PESRELLAQLLLLLSSPPGDD-----------LSRFVDEdYSAARV--TVRLKDL----DSEEIKA 567
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1049 ALESARKISANItqmlqgrlmsngvpmASALTVEVFPYSVFYVFYEqyltMWSDTLQSMGISVLSIFVVTFVLMGFDVHS 1128
Cdd:COG1033 568 LVEEVRAFLAEN---------------FPPDGVEVTLTGSAVLFAA----INESVIESQIRSLLLALLLIFLLLLLAFRS 628
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1129 ---ALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSF--ATSKSVSQIDRAADSLSKMGSSI 1203
Cdd:COG1033 629 lrlGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYreERRKGGDLEEAIRRALRTTGKAI 708
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|..
gi 665407388 1204 -FSGITLtkFAGILVLAFAKSQIFQvfYFRMYLGIVVIGAAHG-LIFLPVLL 1253
Cdd:COG1033 709 lFTSLTL--AAGFGVLLFSSFPPLA--DFGLLLALGLLVALLAaLLLLPALL 756
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
1099-1268 |
6.65e-14 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 76.44 E-value: 6.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1099 MWSDTLQSMGISVLSIFVVTFVLMGfDVHSALVVVITITM-IVVNLGgLMYYWNISLNAVS--LVNLVMAVGISveFCSH 1175
Cdd:COG1033 216 IQSDLAIFFPLALLLILLLLFLFFR-SLRGVLLPLLVVLLaVIWTLG-LMGLLGIPLSPLTilVPPLLLAIGID--YGIH 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1176 LVHSF--ATSKSVSQIDRAADSLSKMGSSIFSGiTLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHgLIFLPVLL 1253
Cdd:COG1033 292 LLNRYreERRKGLDKREALREALRKLGPPVLLT-SLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS-LTLLPALL 369
|
170
....*....|....*
gi 665407388 1254 SYIGAPVSNARLRYH 1268
Cdd:COG1033 370 SLLPRPKPKTRRLKK 384
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
321-772 |
2.52e-11 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 68.35 E-value: 2.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 321 SYFEKL-----GAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKlWASPNSKSRLEREFFD 395
Cdd:COG1033 370 SLLPRPkpktrRLKKPPELGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFED-YLPEDSPIRQDLDFIE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 396 TKFSPFYRLEqIIIKAVNLpqivhntsngpytfGPVFDREFLTKVLDLQEGIKEINangtqlkdicyaplsddgseiDVS 475
Cdd:COG1033 449 ENFGGSDPLE-VVVDTGEP--------------DGLKDPEVLKEIDRLQDYLESLP---------------------EVG 492
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 476 QcvVQSI--------WGYFGDDRE--RLDDHDEdngfnvtYLDALYDCISNPylclapyggpvdPAIALGGFLPPGDQLT 545
Cdd:COG1033 493 K--VLSLadlvkelnQALNEGDPKyyALPESRE-------LLAQLLLLLSSP------------PGDDLSRFVDEDYSAA 551
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 546 gstkfelanaiILTFLVKNHhnktDLENALTWEKKFVEFMTNYTKNNMsqyMDIAFTSERSIEDELNRESQSD-VLTILV 624
Cdd:COG1033 552 -----------RVTVRLKDL----DSEEIKALVEEVRAFLAENFPPDG---VEVTLTGSAVLFAAINESVIESqIRSLLL 613
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 625 SYLIMFMYIAISLGHVKefkrvfidskitLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPfLVLAVGVDN-IFIL 703
Cdd:COG1033 614 ALLLIFLLLLLAFRSLR------------LGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYtIHFL 680
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665407388 704 vqTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAG----VALIIDFLL 772
Cdd:COG1033 681 --SRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLAlgllVALLAALLL 751
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
658-1259 |
7.49e-11 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 66.78 E-value: 7.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 658 GVIIVLASVVSSVGVFGYIGLPATLIIVEVIPfLVLAVGVDNIfilVQTHQR--DQRKPNETLEQQVGRILGKVGPSMLL 735
Cdd:TIGR00921 223 PLVIILFGVAWVLGIMGWLGIPLYATTLLAVP-MLIGVGIDYG---IQTLNRyeEERDIGRAKGEAIVTAVRRTGRAVLI 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 736 TSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRmdiccfikgKKPDSITSNEGLLY 815
Cdd:TIGR00921 299 ALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIDIGREKVK---------KEIIAIGGKSSEIE 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 816 KFFSSVyvpflMKKIVRASV--MVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNI-GPPVYFVLKG 892
Cdd:TIGR00921 370 EELSKV-----LSITVRHPVpaLVAALIITGLGLYGAAGIKPEVNIEKFIPQDLPSLQARKVIESHMGGsHDFATILVKA 444
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 893 DLAytnssdqnlvcagqycNDDSVLTQIYLASRHSNqtyiarpASSWIDDYFDwaaaASSCCKYRKDSGDFCPhQDTSCL 972
Cdd:TIGR00921 445 DDV----------------RDPELVRFMDELSRDIK-------ATGVAARVFG----APSIIDLVKEVEGLPA-PERSAL 496
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 973 rcnitkNSLLRPEEKEFVKylpfflkdnpddtcakaghaayGGAVRYSNSHERLNIeasyfmayhTILKSSADYFLAles 1052
Cdd:TIGR00921 497 ------EPIPEDEEGGYIS----------------------GGQIKVAVIQVQLKQ---------GEPKVQGRKILR--- 536
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1053 arkisanitqMLQGRLMSNGVpmasalTVEVFPYSVfyVFYEQYLTMWSDtlQSMgISVLSIFVVTFVLMGF--DVHSAL 1130
Cdd:TIGR00921 537 ----------DVQHEHPPPGV------KVGVTGLPV--AFAEMHELVNEG--MRR-MTIAGAILVLMILLAVfrNPIKAV 595
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1131 VVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHS-FATSKSVSQIDRAADSLSKMGSSIFSGiTL 1209
Cdd:TIGR00921 596 FPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERyFEERKEHGPKEAITHTMERTGPGILFS-GL 674
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|
gi 665407388 1210 TKFAGILVLAFAKSQIFQVFYFrmylgIVVIGaahglIFLPVLLSYIGAP 1259
Cdd:TIGR00921 675 TTAGGFLSLLLSHFPIMRNFGL-----VQGIG-----VLSSLTAALVVFP 714
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
1114-1220 |
5.31e-05 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 47.72 E-value: 5.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1114 IFVVTFVLMGF--DVHSALVVVITI------TMIVvnlgglMYYWNISLNAVSLVNLVMAVG-------ISVEFC-SHLV 1177
Cdd:COG3696 345 ALLVILVLFLFlgNLRAALIVALAIplsllfAFIV------MRLFGISANLMSLGGLAIDFGiivdgavVMVENIlRRLE 418
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 665407388 1178 HSFATSKSVSQIDRAADSLSKMGSSIFSGITltkfagILVLAF 1220
Cdd:COG3696 419 ENRAAGTPRERLEVVLEAAREVRRPIFFATL------IIILVF 455
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
1093-1256 |
8.39e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 47.14 E-value: 8.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1093 YEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGgLMYYWNISLNAVSLVNLVMAVGISVEF 1172
Cdd:TIGR00921 185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLG-IMGWLGIPLYATTLLAVPMLIGVGIDY 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1173 CSHLVHSFATS----KSVSQIdrAADSLSKMGSSIFsGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVViGAAHGLIF 1248
Cdd:TIGR00921 264 GIQTLNRYEEErdigRAKGEA--IVTAVRRTGRAVL-IALLTTSAGFAALALSEFPMVSEFGLGLVAGLIT-AYLLTLLV 339
|
....*...
gi 665407388 1249 LPVLLSYI 1256
Cdd:TIGR00921 340 LPALLQSI 347
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
610-783 |
8.60e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 46.75 E-value: 8.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 610 ELNRESQSDVLTI-LVSYLIMFMYIAIslghvkefkrVFIDskITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVI 688
Cdd:TIGR00921 560 EMHELVNEGMRRMtIAGAILVLMILLA----------VFRN--PIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTI 627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 689 PfLVLAVGVD-NIFILVQ-THQRDQRKPNETLEQQVGRilgkVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVAL 766
Cdd:TIGR00921 628 S-IILGLGMDySIHLAERyFEERKEHGPKEAITHTMER----TGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGV 702
|
170
....*....|....*..
gi 665407388 767 IIDFLLQITCFVSLFTL 783
Cdd:TIGR00921 703 LSSLTAALVVFPALLVL 719
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
1101-1228 |
1.72e-04 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 46.13 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1101 SDTLQSMGISVLSIFVVTFVLMGfDVHSALVVVITITmiVVNLGGL--MYYWNISLNAVSLVNLVMAVGISV-------E 1171
Cdd:pfam00873 331 EEVVKTLLEAIVLVILVMFLFLQ-NWRATLIPAIAIP--LSLLGTFavMKAFGFSINTLTLGGLVLAIGLVVddaivvvE 407
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665407388 1172 FCS------HLVHSFATSKSVSQIDRAADSLSKMGSSIF------SGIT---LTKFAGILVLAFAKSQIFQV 1228
Cdd:pfam00873 408 NIErvleenGLKPLEAAYKSMGEIGGALVAIALVLSAVFlpilflGGLTgriFRQFAITIVLAILLSVLVAL 479
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
656-775 |
4.58e-04 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 43.82 E-value: 4.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 656 IGGVIIVLASVVSSVGVFGY---IGLPATLIIVEVIpfLVLAVGVD-NIFILvqTHQRDQRKPNETLEQQVGRILGKVGP 731
Cdd:pfam03176 173 LLTVGLSLGAAQGLVAILAHilgIGLSTFALNLLVV--LLIAVGTDyALFLV--SRYREELRAGEDREEAVIRAVRGTGK 248
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 665407388 732 SMLLTSLSesFCFFLGGL--SDMPAVRAFALYAGVALIIDFLLQIT 775
Cdd:pfam03176 249 VVTAAGLT--VAIAMLALsfARLPVFAQVGPTIAIGVLVDVLAALT 292
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
1092-1264 |
7.72e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 43.69 E-value: 7.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1092 FYEQYLTmwsDTLQSMGISVLSIFVVtFVLMGFDVHSALVVVI--TITMIVVnLGgLMYYWNISLNAVSLVNLVMAVGIS 1169
Cdd:COG4258 633 LFGRYRN---DALWLLLLALLLILLL-LLLRLRSLRRALRVLLppLLAVLLT-LA-ILGLLGIPLNLFHLIALLLVLGIG 706
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1170 VEFCshLvhsFATsksvSQIDRAADSLSKMGSSIFSgiTLTKFAGILVLAFAKSQIFQVFyfrmylGIVV-IGaahglIF 1248
Cdd:COG4258 707 IDYA--L---FFT----EGLLDKGELARTLLSILLA--ALTTLLGFGLLAFSSTPALRSF------GLTVlLG-----IL 764
|
170
....*....|....*.
gi 665407388 1249 LPVLLSYIGAPVSNAR 1264
Cdd:COG4258 765 LALLLAPLLAPRRRPR 780
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
1101-1264 |
1.94e-03 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 42.78 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1101 SDTLQSMGISVLSIFVVTFVLMGfDVHSALVVVITI------TMIVvnlgglMYYWNISLNAVSLVNLVMAVGISV---- 1170
Cdd:COG0841 331 EEVVKTLLEAILLVVLVVFLFLR-SWRATLIPAVAIpvsligTFAV------MYLLGFSLNILTLFALVLAIGIVVddai 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 1171 ---EFCSHLVHsfatsKSVSQIDRAADSLSKMGSSIFSgITLTkfagiLVLAFAK----SQIFQVFYFrmYLGIVVIGA- 1242
Cdd:COG0841 404 vvvENIERHME-----EGLSPLEAAIKGAREVAGAVIA-STLT-----LVAVFLPlafmGGITGQLFR--QFALTVAIAl 470
|
170 180
....*....|....*....|....*...
gi 665407388 1243 ------AhgLIFLPVLLSYIGAPVSNAR 1264
Cdd:COG0841 471 lislfvA--LTLTPALCARLLKPHPKGK 496
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
622-773 |
4.55e-03 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 41.38 E-value: 4.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407388 622 ILVSYLIMFMYIAISLGHVKEFKRVfidskitlgiggVIIVLASVVSSVGVFGYIGLPATLIIVeVIPFLVLAVGVD-NI 700
Cdd:COG4258 645 LLLALLLILLLLLLRLRSLRRALRV------------LLPPLLAVLLTLAILGLLGIPLNLFHL-IALLLVLGIGIDyAL 711
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665407388 701 FIlvqthQRDQRKPNETLEQQVGRILgkvgpSMLLTSLSesfcFFLGGLSDMPAVRAF----ALYAGVALIIDFLLQ 773
Cdd:COG4258 712 FF-----TEGLLDKGELARTLLSILL-----AALTTLLG----FGLLAFSSTPALRSFgltvLLGILLALLLAPLLA 774
|
|
| |
