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Conserved domains on  [gi|665408864|ref|NP_001286113|]
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uncharacterized protein Dmel_CG31676, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Twit cd23593
extracellular domain (ECD) found in Drosophila melanogaster Target of wit (Twit) and similar ...
 27-132 9.87e-36

extracellular domain (ECD) found in Drosophila melanogaster Target of wit (Twit) and similar proteins; Twit is a GPI-anchored membrane ligand of the Ly6 family that participates in retrograde signalling as a downstream target of the bone morphogenetic protein (BMP) pathway receptor encoded by Wishful thinking (Wit). It acts in neurons, regulating spontaneous neurotransmitter release during the maturation of larval neuromuscular junctions. Twit contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467122  Cd Length: 101  Bit Score: 119.43  E-value: 9.87e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408864  27 LRCWRCSTDVSNgeFCNDPFMPEtiseqQRYWSYVNCTYSVGAKSV-NARPVCKKLVQEVYGKRVISRSCFYEDMDDSAD 105
Cdd:cd23593    2 LRCWSCSSDTDP--FCGDPFNTT-----ENHFHLTDCDRTASPSYYlNERPVCRKIVQRVNGELVVIRSCAWENEDDVDG 74

                         90       100
                 ....*....|....*....|....*..
gi 665408864 106 KCANDQTSSYIKTVYCRTCTTDGCNGA 132
Cdd:cd23593   75 PCSNTSTGSYIKIESCETCSTDGCNSA 101
 
Name Accession Description Interval E-value
TFP_LU_ECD_Twit cd23593
extracellular domain (ECD) found in Drosophila melanogaster Target of wit (Twit) and similar ...
 27-132 9.87e-36

extracellular domain (ECD) found in Drosophila melanogaster Target of wit (Twit) and similar proteins; Twit is a GPI-anchored membrane ligand of the Ly6 family that participates in retrograde signalling as a downstream target of the bone morphogenetic protein (BMP) pathway receptor encoded by Wishful thinking (Wit). It acts in neurons, regulating spontaneous neurotransmitter release during the maturation of larval neuromuscular junctions. Twit contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467122  Cd Length: 101  Bit Score: 119.43  E-value: 9.87e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408864  27 LRCWRCSTDVSNgeFCNDPFMPEtiseqQRYWSYVNCTYSVGAKSV-NARPVCKKLVQEVYGKRVISRSCFYEDMDDSAD 105
Cdd:cd23593    2 LRCWSCSSDTDP--FCGDPFNTT-----ENHFHLTDCDRTASPSYYlNERPVCRKIVQRVNGELVVIRSCAWENEDDVDG 74

                         90       100
                 ....*....|....*....|....*..
gi 665408864 106 KCANDQTSSYIKTVYCRTCTTDGCNGA 132
Cdd:cd23593   75 PCSNTSTGSYIKIESCETCSTDGCNSA 101
QVR pfam17064
Sleepless protein; In Drosophila QUIVER (also known as SLEEPLESS protein) is required for ...
 27-130 5.72e-04

Sleepless protein; In Drosophila QUIVER (also known as SLEEPLESS protein) is required for homoeostatic regulation of sleep under normal conditions and following sleep deprivation. It is a novel potassium channel subunit that modulates the Shaker potassium channel which regulates the sleep.


Pssm-ID: 435716  Cd Length: 85  Bit Score: 36.81  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408864   27 LRCWRCSTDVSngEFCNDPFMPETISEQqrywsYVNCTYsvgaksvnarpVCKKLVQEV-YGKRVISRSCFYEDMDDSAD 105
Cdd:pfam17064   1 IKCYSCNSSDD--PGCGDPFPFNSSSIK-----LVDCDG-----------GCVKIKTKGsGGSTRVTRGCGPELTEDIKD 62

                          90       100
                  ....*....|....*....|....*
gi 665408864  106 KCAndQTSSYIKTVYCRTCTTDGCN 130
Cdd:pfam17064  63 GCS--SSSSGGGGTITCFCNTDLCN 85
 
Name Accession Description Interval E-value
TFP_LU_ECD_Twit cd23593
extracellular domain (ECD) found in Drosophila melanogaster Target of wit (Twit) and similar ...
 27-132 9.87e-36

extracellular domain (ECD) found in Drosophila melanogaster Target of wit (Twit) and similar proteins; Twit is a GPI-anchored membrane ligand of the Ly6 family that participates in retrograde signalling as a downstream target of the bone morphogenetic protein (BMP) pathway receptor encoded by Wishful thinking (Wit). It acts in neurons, regulating spontaneous neurotransmitter release during the maturation of larval neuromuscular junctions. Twit contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467122  Cd Length: 101  Bit Score: 119.43  E-value: 9.87e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408864  27 LRCWRCSTDVSNgeFCNDPFMPEtiseqQRYWSYVNCTYSVGAKSV-NARPVCKKLVQEVYGKRVISRSCFYEDMDDSAD 105
Cdd:cd23593    2 LRCWSCSSDTDP--FCGDPFNTT-----ENHFHLTDCDRTASPSYYlNERPVCRKIVQRVNGELVVIRSCAWENEDDVDG 74

                         90       100
                 ....*....|....*....|....*..
gi 665408864 106 KCANDQTSSYIKTVYCRTCTTDGCNGA 132
Cdd:cd23593   75 PCSNTSTGSYIKIESCETCSTDGCNSA 101
QVR pfam17064
Sleepless protein; In Drosophila QUIVER (also known as SLEEPLESS protein) is required for ...
 27-130 5.72e-04

Sleepless protein; In Drosophila QUIVER (also known as SLEEPLESS protein) is required for homoeostatic regulation of sleep under normal conditions and following sleep deprivation. It is a novel potassium channel subunit that modulates the Shaker potassium channel which regulates the sleep.


Pssm-ID: 435716  Cd Length: 85  Bit Score: 36.81  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408864   27 LRCWRCSTDVSngEFCNDPFMPETISEQqrywsYVNCTYsvgaksvnarpVCKKLVQEV-YGKRVISRSCFYEDMDDSAD 105
Cdd:pfam17064   1 IKCYSCNSSDD--PGCGDPFPFNSSSIK-----LVDCDG-----------GCVKIKTKGsGGSTRVTRGCGPELTEDIKD 62

                          90       100
                  ....*....|....*....|....*
gi 665408864  106 KCAndQTSSYIKTVYCRTCTTDGCN 130
Cdd:pfam17064  63 GCS--SSSSGGGGTITCFCNTDLCN 85
TFP_LU_ECD_Crok cd23592
extracellular domain (ECD), Ly6/uPAR superfamily, three finger domain (TFD) fold, found in ...
 27-132 1.21e-03

extracellular domain (ECD), Ly6/uPAR superfamily, three finger domain (TFD) fold, found in Drosophila melanogaster protein crooked and similar proteins; Crooked (Crok) is a glycosylphosphatidylinositol (GPI)-anchored protein that plays an essential role in septa formation, the membrane accumulation of SJ components and paracellular barrier functions. It required for septate junction (SJ) formation and function in a tissue-autonomous manner. Crooked is specifically required for correct membrane trafficking of Neurexin IV, a central SJ component. Crooked is a member of the Drosophila Ly6 superfamily. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467121  Cd Length: 104  Bit Score: 36.32  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408864  27 LRCWRCSTDVSNGefCNDPFmpetiseQQRYWSYVNCTYSV------GAKSvnarPVCKKLVQEVYGKRVISRSCFYED- 99
Cdd:cd23592    3 IKCWVCRSDYDPR--CGDPF-------DNLTLPITDCNQEKkphhlpGVKA----TMCRKMRQKVNGEWRYIRSCAFLGe 69

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 665408864 100 --MDDSADKCANDQTSSYIKTVYCRTCTTDGCNGA 132
Cdd:cd23592   70 pgIGGDERWCLERSGTYNIHIEDCTCNSKDGCNAA 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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