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Conserved domains on  [gi|665399578|ref|NP_001286202|]
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uncharacterized protein Dmel_CG8635, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5252 super family cl34956
Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function ...
 1-314 3.22e-54

Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only];


The actual alignment was detected with superfamily member COG5252:

Pssm-ID: 227577 [Multi-domain]  Cd Length: 299  Bit Score: 181.83  E-value: 3.22e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399578   1 MPPKKAPPGP--SKKTEQKKKEKVIEDKTFGLKNKKGNKQqkfIQQVQKQVQSggqhprqdgdkRKEEKEKKLAEQREMA 78
Cdd:COG5252    1 MPPKKMAKKQqeSGKKATRDMRKELEDKTFGLKNKNRSTK---VQAIIKQIET-----------LNLKEQLEKKEKMRME 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399578  79 LIFKPVQTQKVEKGTDPKSVVCAFFKQGTCTKGDKCKFSHDLSQENKVEKRSIYVDMRD--EDDPMtnwddaklkevvek 156
Cdd:COG5252   67 EKRREPEKQVIRAGVDPKTVVCALFLNKTCAKGDACKFAHGKEEARKTEKPDLYSDVRDkeEDVPL-------------- 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399578 157 kssGEKQRPTTDIICKFFLEAVEKSKYGWFWECPNGG-KCIYRHALPAGYVLKRDKKKEEKPTEISLVDLIEKERAALGP 235
Cdd:COG5252  133 ---GKRPWINTDRVCKFFIEAMESGKYGWGWTCPNGNmRCSYIHKLPDGYVLSRDKIKDSTQVEISLEEFIELERQSLPE 209

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665399578 236 NQTRVTLESFLAWKKRKIAekkAKLAAEEERKKSDFSKGKQFGISGREMFSFNPDLVDDGPMEEGDAAFDVYNREDDDD 314
Cdd:COG5252  210 KLTPLTEENFKEWKDGRRL---RILKQKEEKESARKVKGRATGTKGVELFETRRDLFKDDVEAGEEWDYTERCYSESED 285
 
Name Accession Description Interval E-value
COG5252 COG5252
Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function ...
 1-314 3.22e-54

Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227577 [Multi-domain]  Cd Length: 299  Bit Score: 181.83  E-value: 3.22e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399578   1 MPPKKAPPGP--SKKTEQKKKEKVIEDKTFGLKNKKGNKQqkfIQQVQKQVQSggqhprqdgdkRKEEKEKKLAEQREMA 78
Cdd:COG5252    1 MPPKKMAKKQqeSGKKATRDMRKELEDKTFGLKNKNRSTK---VQAIIKQIET-----------LNLKEQLEKKEKMRME 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399578  79 LIFKPVQTQKVEKGTDPKSVVCAFFKQGTCTKGDKCKFSHDLSQENKVEKRSIYVDMRD--EDDPMtnwddaklkevvek 156
Cdd:COG5252   67 EKRREPEKQVIRAGVDPKTVVCALFLNKTCAKGDACKFAHGKEEARKTEKPDLYSDVRDkeEDVPL-------------- 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399578 157 kssGEKQRPTTDIICKFFLEAVEKSKYGWFWECPNGG-KCIYRHALPAGYVLKRDKKKEEKPTEISLVDLIEKERAALGP 235
Cdd:COG5252  133 ---GKRPWINTDRVCKFFIEAMESGKYGWGWTCPNGNmRCSYIHKLPDGYVLSRDKIKDSTQVEISLEEFIELERQSLPE 209

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665399578 236 NQTRVTLESFLAWKKRKIAekkAKLAAEEERKKSDFSKGKQFGISGREMFSFNPDLVDDGPMEEGDAAFDVYNREDDDD 314
Cdd:COG5252  210 KLTPLTEENFKEWKDGRRL---RILKQKEEKESARKVKGRATGTKGVELFETRRDLFKDDVEAGEEWDYTERCYSESED 285
DFRP_C pfam16543
DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation ...
 219-310 1.94e-25

DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation machinery-associated protein 46 proteins that are the binding partner for the highly conserved Developmentally Regulated GTP-binding (DRG) GTPases. Thus this family is referred to as DRG Family Regulatory Proteins (DFRP). Binding of this DFRP modulates the function of the GTPase.


Pssm-ID: 465167  Cd Length: 89  Bit Score: 98.81  E-value: 1.94e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399578  219 EISLVDLIEKERAALGPNQTRVTLESFLAWKKRKIAEKKAKLAAEEERKKSDfskgkqfGISGREMFSFNPDLVDDGPME 298
Cdd:pfam16543   1 KITLEEFIETERHKLDKKLTPVTPETFAKWKKKRIDKKEAEEEAERKKKKAD-------GLSGRELFEFNPDLFEDDDED 73

                          90
                  ....*....|..
gi 665399578  299 EGDAAFDVYNRE 310
Cdd:pfam16543  74 EDDDEDEAWDLS 85
ZnF_C3H1 smart00356
zinc finger;
94-120 3.70e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 46.08  E-value: 3.70e-07
                           10        20
                   ....*....|....*....|....*..
gi 665399578    94 DPKSVVCAFFKQGTCTKGDKCKFSHDL 120
Cdd:smart00356   1 KYKTELCKFFKRGYCPRGDRCKFAHPL 27
 
Name Accession Description Interval E-value
COG5252 COG5252
Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function ...
 1-314 3.22e-54

Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227577 [Multi-domain]  Cd Length: 299  Bit Score: 181.83  E-value: 3.22e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399578   1 MPPKKAPPGP--SKKTEQKKKEKVIEDKTFGLKNKKGNKQqkfIQQVQKQVQSggqhprqdgdkRKEEKEKKLAEQREMA 78
Cdd:COG5252    1 MPPKKMAKKQqeSGKKATRDMRKELEDKTFGLKNKNRSTK---VQAIIKQIET-----------LNLKEQLEKKEKMRME 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399578  79 LIFKPVQTQKVEKGTDPKSVVCAFFKQGTCTKGDKCKFSHDLSQENKVEKRSIYVDMRD--EDDPMtnwddaklkevvek 156
Cdd:COG5252   67 EKRREPEKQVIRAGVDPKTVVCALFLNKTCAKGDACKFAHGKEEARKTEKPDLYSDVRDkeEDVPL-------------- 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399578 157 kssGEKQRPTTDIICKFFLEAVEKSKYGWFWECPNGG-KCIYRHALPAGYVLKRDKKKEEKPTEISLVDLIEKERAALGP 235
Cdd:COG5252  133 ---GKRPWINTDRVCKFFIEAMESGKYGWGWTCPNGNmRCSYIHKLPDGYVLSRDKIKDSTQVEISLEEFIELERQSLPE 209

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665399578 236 NQTRVTLESFLAWKKRKIAekkAKLAAEEERKKSDFSKGKQFGISGREMFSFNPDLVDDGPMEEGDAAFDVYNREDDDD 314
Cdd:COG5252  210 KLTPLTEENFKEWKDGRRL---RILKQKEEKESARKVKGRATGTKGVELFETRRDLFKDDVEAGEEWDYTERCYSESED 285
DFRP_C pfam16543
DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation ...
 219-310 1.94e-25

DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation machinery-associated protein 46 proteins that are the binding partner for the highly conserved Developmentally Regulated GTP-binding (DRG) GTPases. Thus this family is referred to as DRG Family Regulatory Proteins (DFRP). Binding of this DFRP modulates the function of the GTPase.


Pssm-ID: 465167  Cd Length: 89  Bit Score: 98.81  E-value: 1.94e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399578  219 EISLVDLIEKERAALGPNQTRVTLESFLAWKKRKIAEKKAKLAAEEERKKSDfskgkqfGISGREMFSFNPDLVDDGPME 298
Cdd:pfam16543   1 KITLEEFIETERHKLDKKLTPVTPETFAKWKKKRIDKKEAEEEAERKKKKAD-------GLSGRELFEFNPDLFEDDDED 73

                          90
                  ....*....|..
gi 665399578  299 EGDAAFDVYNRE 310
Cdd:pfam16543  74 EDDDEDEAWDLS 85
ZnF_C3H1 smart00356
zinc finger;
94-120 3.70e-07

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 46.08  E-value: 3.70e-07
                           10        20
                   ....*....|....*....|....*..
gi 665399578    94 DPKSVVCAFFKQGTCTKGDKCKFSHDL 120
Cdd:smart00356   1 KYKTELCKFFKRGYCPRGDRCKFAHPL 27
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 100-118 6.36e-07

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 45.10  E-value: 6.36e-07
                          10
                  ....*....|....*....
gi 665399578  100 CAFFKQGTCTKGDKCKFSH 118
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 98-119 4.96e-05

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 39.88  E-value: 4.96e-05
                          10        20
                  ....*....|....*....|..
gi 665399578   98 VVCAFFKQGTCTKGDKCKFSHD 119
Cdd:pfam18044   1 RLCRYFQKGGCRYGDNCRFSHD 22
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
95-119 1.27e-04

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 38.71  E-value: 1.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 665399578   95 PKSVVCAFFKQ-GTCTKGDKCKFSHD 119
Cdd:pfam00642   1 YKTELCRFFLRtGYCKYGDRCKFAHG 26
zf-CCCH_2 pfam14608
RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented ...
 100-118 5.02e-03

RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented by fingers 5-7 of Nab2. Nab2 ZnF5-7 are zinc-fingers of the type C-x8-C-x5-C-x3-H. Nab2 ZnFs function in the generation of export-competent mRNPs. Mab2 is a conserved polyadenosine-RNA-binding Zn finger protein required for both mRNA export and polyadenylation regulation and becomes attached to the mRNP after splicing and during or immediately after polyadenylation. The three ZnFs, 5-7, have almost identical folds and, most unusually, associate with one another to form a single coherent structural unit. ZnF5-7 bind to eight consecutive adenines, and chemical shift perturbations identify residues on each finger that interact with RNA.


Pssm-ID: 464217  Cd Length: 19  Bit Score: 34.02  E-value: 5.02e-03
                          10
                  ....*....|....*....
gi 665399578  100 CAFFkqGTCTKGDKCKFSH 118
Cdd:pfam14608   2 CRFG--GNCTFGPKCPFSH 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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