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Conserved domains on  [gi|665393932|ref|NP_001287306|]
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dipeptidase C, isoform B [Drosophila melanogaster]

Protein Classification

aminopeptidase P family protein( domain architecture ID 10659798)

aminopeptidase family protein P (peptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

CATH:  3.40.350.10|3.90.230.10
EC:  3.4.11.-
Gene Ontology:  GO:0004177|GO:0016020|GO:0070006|GO:0046872|GO:0006508
MEROPS:  M24
PubMed:  30066404|9434107|12475202

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 195-468 9.25e-123

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


:

Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 358.42  E-value: 9.25e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 195 IEVLRYVAKVSSDAHIKVMRFMRPGRMEFEGESLFLHHAYSVGGCRHASYTCICGSgtNSSILHYGHagapNSKPVQDGD 274
Cdd:cd01087    1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLAYSYIVAAGS--NAAILHYVH----NDQPLKDGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 275 LCLFDMGANYCGYAADITCTFPANGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLAGRVLLQRLKEGGMLKGDV 354
Cdd:cd01087   75 LVLIDAGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 355 EEMLEAGVSGVFQPHGLGHLIGLDVHDVGGYLPkepkrpsepwlsKLRFARILKAGMYVTIEPGCYFINWLMDRaladpn 434
Cdd:cd01087  155 DEIVESGAYAKFFPHGLGHYLGLDVHDVGGYLR------------YLRRARPLEPGMVITIEPGIYFIPDLLDV------ 216

                        250       260       270
                 ....*....|....*....|....*....|....
gi 665393932 435 iakfinaemfNRFRNFGGVRIEDDVLITKTGVEN 468
Cdd:cd01087  217 ----------PEYFRGGGIRIEDDVLVTEDGPEN 240
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 12-158 3.46e-35

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


:

Pssm-ID: 198079  Cd Length: 135  Bit Score: 127.74  E-value: 3.46e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932    12 VPMTLFRNNRDRagkaiLKELLPglkfnDGNLLVLLEGGKDQSlyNTDVDYVFRQESYFQYLFGVKEPGCYGILtiDVKT 91
Cdd:smart01011   1 IPAAEYAARRRR-----LAAKLF-----PGSVAVLPAGPEKVR--SNDTDYPFRQDSDFYYLTGFDEPDAVLVL--DPSG 66

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665393932    92 GAQKSVLFVPRFPDEYGTWMGELLGLQEFKAMYEVDEVFYVDEMSVYLEG--ASPKLILTLSGTNSDSG 158
Cdd:smart01011  67 GGGKSTLFVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGllAGAGTVYYLLGRDPDLD 135
 
Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 195-468 9.25e-123

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 358.42  E-value: 9.25e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 195 IEVLRYVAKVSSDAHIKVMRFMRPGRMEFEGESLFLHHAYSVGGCRHASYTCICGSgtNSSILHYGHagapNSKPVQDGD 274
Cdd:cd01087    1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLAYSYIVAAGS--NAAILHYVH----NDQPLKDGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 275 LCLFDMGANYCGYAADITCTFPANGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLAGRVLLQRLKEGGMLKGDV 354
Cdd:cd01087   75 LVLIDAGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 355 EEMLEAGVSGVFQPHGLGHLIGLDVHDVGGYLPkepkrpsepwlsKLRFARILKAGMYVTIEPGCYFINWLMDRaladpn 434
Cdd:cd01087  155 DEIVESGAYAKFFPHGLGHYLGLDVHDVGGYLR------------YLRRARPLEPGMVITIEPGIYFIPDLLDV------ 216

                        250       260       270
                 ....*....|....*....|....*....|....
gi 665393932 435 iakfinaemfNRFRNFGGVRIEDDVLITKTGVEN 468
Cdd:cd01087  217 ----------PEYFRGGGIRIEDDVLVTEDGPEN 240
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 57-483 4.16e-75

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 243.09  E-value: 4.16e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932  57 NTDVDYVFRQESYFQYLFGVKEPGCYGILtIDVKTGAQKSVLFvPRFPDEYG-TWMGELLGLQEFKAMYEVDEVFYVDEM 135
Cdd:PRK10879  34 SADSEYPYRQNSDFWYFTGFNEPEAVLVL-IKSDDTHNHSVLF-NRVRDLTAeIWFGRRLGQDAAPEKLGVDRALPFSEI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 136 S------------VY-----LEGASPKLILTLSGTNSDSGLTLQPPdfagkeKYVTDCNllyPILSECRVIKSPEEIEVL 198
Cdd:PRK10879 112 NqqlyqllngldvVYhaqgeYAYADEIVFSALEKLRKGSRQNLTAP------ATLTDWR---PWVHEMRLFKSPEEIAVL 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 199 RYVAKVSSDAHIKVMRFMRPGRMEF--EGEslfLHHAYSVGGCRHASYTCICGSGTNSSILHYghagAPNSKPVQDGDLC 276
Cdd:PRK10879 183 RRAGEISALAHTRAMEKCRPGMFEYqlEGE---IHHEFNRHGARYPSYNTIVGSGENGCILHY----TENESEMRDGDLV 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 277 LFDMGANYCGYAADITCTFPANGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLAGRVLLQRLKEGGMLKGDVEE 356
Cdd:PRK10879 256 LIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSLRLYRPGTSIREVTGEVVRIMVSGLVKLGILKGDVDQ 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 357 MLEAGVSGVFQPHGLGHLIGLDVHDVGGYLPKEpkrpsepwlsklrfARILKAGMYVTIEPGCYfinwlmdraladpnIA 436
Cdd:PRK10879 336 LIAENAHRPFFMHGLSHWLGLDVHDVGVYGQDR--------------SRILEPGMVLTVEPGLY--------------IA 387

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 665393932 437 KfiNAEMFNRFRNFgGVRIEDDVLITKTGVENF-AIVPRTVEDIEATM 483
Cdd:PRK10879 388 P--DADVPEQYRGI-GIRIEDDIVITETGNENLtASVVKKPDEIEALM 432
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
179-479 4.60e-73

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 233.17  E-value: 4.60e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 179 LYPILSECRVIKSPEEIEVLRYVAKVSSDAHIKVMRFMRPGRMEFE--GEslfLHHAYSVGGCRHASYTCICGSGTNSSI 256
Cdd:COG0006   63 ASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREvaAE---LEAAMRRRGAEGPSFDTIVASGENAAI 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 257 LHYGhagaPNSKPVQDGDLCLFDMGANYCGYAADITCTFPAnGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLA 336
Cdd:COG0006  140 PHYT----PTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAV-GEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAA 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 337 GRVllqrLKEGGMLKgdveemleagvsgvFQPHGLGHLIGLDVHDVggylpkepkrpsePWLSKlRFARILKAGMYVTIE 416
Cdd:COG0006  215 RDV----LAEAGYGE--------------YFPHGTGHGVGLDVHEG-------------PQISP-GNDRPLEPGMVFTIE 262

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665393932 417 PGCYFINWlmdraladpniakfinaemfnrfrnfGGVRIEDDVLITKTGVENFAIVPRTVEDI 479
Cdd:COG0006  263 PGIYIPGI--------------------------GGVRIEDTVLVTEDGAEVLTRLPRELLEL 299
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 196-463 1.01e-59

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 195.15  E-value: 1.01e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932  196 EVLRYVAKVSSDAHIKVMRFMRPGRMEFEGESLFLHHAYSVGGCRHASYTCICGSGTNSSILHYghagAPNSKPVQDGDL 275
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHY----IPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932  276 CLFDMGANYC-GYAADITCTFpANGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLAGRVllqrLKEGGMlkgdv 354
Cdd:pfam00557  77 VLIDVGAEYDgGYCSDITRTF-VVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREV----LEEAGL----- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932  355 eemleagvsGVFQPHGLGHLIGLDVHDvggylpkepkrpsEPWLSKLRFARILKAGMYVTIEPGCYFInwlmdraladpn 434
Cdd:pfam00557 147 ---------GEYFPHGLGHGIGLEVHE-------------GPYISRGGDDRVLEPGMVFTIEPGIYFI------------ 192

                         250       260
                  ....*....|....*....|....*....
gi 665393932  435 iakfinaemfnrfRNFGGVRIEDDVLITK 463
Cdd:pfam00557 193 -------------PGWGGVRIEDTVLVTE 208
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 12-158 3.46e-35

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


Pssm-ID: 198079  Cd Length: 135  Bit Score: 127.74  E-value: 3.46e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932    12 VPMTLFRNNRDRagkaiLKELLPglkfnDGNLLVLLEGGKDQSlyNTDVDYVFRQESYFQYLFGVKEPGCYGILtiDVKT 91
Cdd:smart01011   1 IPAAEYAARRRR-----LAAKLF-----PGSVAVLPAGPEKVR--SNDTDYPFRQDSDFYYLTGFDEPDAVLVL--DPSG 66

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665393932    92 GAQKSVLFVPRFPDEYGTWMGELLGLQEFKAMYEVDEVFYVDEMSVYLEG--ASPKLILTLSGTNSDSG 158
Cdd:smart01011  67 GGGKSTLFVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGllAGAGTVYYLLGRDPDLD 135
AMP_N pfam05195
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 17-139 1.04e-32

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families.


Pssm-ID: 461581 [Multi-domain]  Cd Length: 121  Bit Score: 120.69  E-value: 1.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932   17 FRNNRDRagkaiLKELLPGlkfndgNLLVLLEGGKDQSLYNtDVDYVFRQESYFQYLFGVKEPGCYGILT-IDVKTGaqK 95
Cdd:pfam05195   1 YAERRAR-----LLAKLPP------NSVAILPGAPEKYRNG-DVFYPFRQDSDFYYLTGFNEPDAVLVLEgGDIDSG--K 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 665393932   96 SVLFVPRFPDEYGTWMGELLGLQEFKAMYEVDEVFYVDEMSVYL 139
Cdd:pfam05195  67 ETLFVPPKDPEDEIWDGPRLGPEEAKELFGVDEVYPIDELDEVL 110
 
Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 195-468 9.25e-123

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 358.42  E-value: 9.25e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 195 IEVLRYVAKVSSDAHIKVMRFMRPGRMEFEGESLFLHHAYSVGGCRHASYTCICGSgtNSSILHYGHagapNSKPVQDGD 274
Cdd:cd01087    1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLAYSYIVAAGS--NAAILHYVH----NDQPLKDGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 275 LCLFDMGANYCGYAADITCTFPANGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLAGRVLLQRLKEGGMLKGDV 354
Cdd:cd01087   75 LVLIDAGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 355 EEMLEAGVSGVFQPHGLGHLIGLDVHDVGGYLPkepkrpsepwlsKLRFARILKAGMYVTIEPGCYFINWLMDRaladpn 434
Cdd:cd01087  155 DEIVESGAYAKFFPHGLGHYLGLDVHDVGGYLR------------YLRRARPLEPGMVITIEPGIYFIPDLLDV------ 216

                        250       260       270
                 ....*....|....*....|....*....|....
gi 665393932 435 iakfinaemfNRFRNFGGVRIEDDVLITKTGVEN 468
Cdd:cd01087  217 ----------PEYFRGGGIRIEDDVLVTEDGPEN 240
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 57-483 4.16e-75

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 243.09  E-value: 4.16e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932  57 NTDVDYVFRQESYFQYLFGVKEPGCYGILtIDVKTGAQKSVLFvPRFPDEYG-TWMGELLGLQEFKAMYEVDEVFYVDEM 135
Cdd:PRK10879  34 SADSEYPYRQNSDFWYFTGFNEPEAVLVL-IKSDDTHNHSVLF-NRVRDLTAeIWFGRRLGQDAAPEKLGVDRALPFSEI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 136 S------------VY-----LEGASPKLILTLSGTNSDSGLTLQPPdfagkeKYVTDCNllyPILSECRVIKSPEEIEVL 198
Cdd:PRK10879 112 NqqlyqllngldvVYhaqgeYAYADEIVFSALEKLRKGSRQNLTAP------ATLTDWR---PWVHEMRLFKSPEEIAVL 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 199 RYVAKVSSDAHIKVMRFMRPGRMEF--EGEslfLHHAYSVGGCRHASYTCICGSGTNSSILHYghagAPNSKPVQDGDLC 276
Cdd:PRK10879 183 RRAGEISALAHTRAMEKCRPGMFEYqlEGE---IHHEFNRHGARYPSYNTIVGSGENGCILHY----TENESEMRDGDLV 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 277 LFDMGANYCGYAADITCTFPANGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLAGRVLLQRLKEGGMLKGDVEE 356
Cdd:PRK10879 256 LIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSLRLYRPGTSIREVTGEVVRIMVSGLVKLGILKGDVDQ 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 357 MLEAGVSGVFQPHGLGHLIGLDVHDVGGYLPKEpkrpsepwlsklrfARILKAGMYVTIEPGCYfinwlmdraladpnIA 436
Cdd:PRK10879 336 LIAENAHRPFFMHGLSHWLGLDVHDVGVYGQDR--------------SRILEPGMVLTVEPGLY--------------IA 387

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 665393932 437 KfiNAEMFNRFRNFgGVRIEDDVLITKTGVENF-AIVPRTVEDIEATM 483
Cdd:PRK10879 388 P--DADVPEQYRGI-GIRIEDDIVITETGNENLtASVVKKPDEIEALM 432
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
179-479 4.60e-73

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 233.17  E-value: 4.60e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 179 LYPILSECRVIKSPEEIEVLRYVAKVSSDAHIKVMRFMRPGRMEFE--GEslfLHHAYSVGGCRHASYTCICGSGTNSSI 256
Cdd:COG0006   63 ASDLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREvaAE---LEAAMRRRGAEGPSFDTIVASGENAAI 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 257 LHYGhagaPNSKPVQDGDLCLFDMGANYCGYAADITCTFPAnGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLA 336
Cdd:COG0006  140 PHYT----PTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAV-GEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAA 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 337 GRVllqrLKEGGMLKgdveemleagvsgvFQPHGLGHLIGLDVHDVggylpkepkrpsePWLSKlRFARILKAGMYVTIE 416
Cdd:COG0006  215 RDV----LAEAGYGE--------------YFPHGTGHGVGLDVHEG-------------PQISP-GNDRPLEPGMVFTIE 262

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665393932 417 PGCYFINWlmdraladpniakfinaemfnrfrnfGGVRIEDDVLITKTGVENFAIVPRTVEDI 479
Cdd:COG0006  263 PGIYIPGI--------------------------GGVRIEDTVLVTEDGAEVLTRLPRELLEL 299
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 196-463 1.01e-59

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 195.15  E-value: 1.01e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932  196 EVLRYVAKVSSDAHIKVMRFMRPGRMEFEGESLFLHHAYSVGGCRHASYTCICGSGTNSSILHYghagAPNSKPVQDGDL 275
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHY----IPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932  276 CLFDMGANYC-GYAADITCTFpANGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLAGRVllqrLKEGGMlkgdv 354
Cdd:pfam00557  77 VLIDVGAEYDgGYCSDITRTF-VVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREV----LEEAGL----- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932  355 eemleagvsGVFQPHGLGHLIGLDVHDvggylpkepkrpsEPWLSKLRFARILKAGMYVTIEPGCYFInwlmdraladpn 434
Cdd:pfam00557 147 ---------GEYFPHGLGHGIGLEVHE-------------GPYISRGGDDRVLEPGMVFTIEPGIYFI------------ 192

                         250       260
                  ....*....|....*....|....*....
gi 665393932  435 iakfinaemfnrfRNFGGVRIEDDVLITK 463
Cdd:pfam00557 193 -------------PGWGGVRIEDTVLVTE 208
PRK13607 PRK13607
proline dipeptidase; Provisional
 187-468 1.25e-58

proline dipeptidase; Provisional


Pssm-ID: 237444 [Multi-domain]  Cd Length: 443  Bit Score: 199.74  E-value: 1.25e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 187 RVIKSPEEIEVLRYVAKVSSDAHIKVMRFMRPGRMEFEgeslfLHHAYsVGGCRHAS----YTCICGSGTNSSILHYGHa 262
Cdd:PRK13607 159 RAYKTDYELACMREAQKIAVAGHRAAKEAFRAGMSEFD-----INLAY-LTATGQRDndvpYGNIVALNEHAAVLHYTK- 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 263 gaPNSKPVQDGDLCLFDMGANYCGYAADITCTFPAngkftdDQKFIYNAVLDARNAVT----ESARDGVSWVDMHKLAGR 338
Cdd:PRK13607 232 --LDHQAPAEMRSFLIDAGAEYNGYAADITRTYAA------KEDNDFAALIKDVNKEQlaliATMKPGVSYVDLHIQMHQ 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 339 VLLQRLKEGGMLKG-DVEEMLEAGVSGVFQPHGLGHLIGLDVHDVGGYLPKEP----KRPSE-PWlskLRFARILKAGMY 412
Cdd:PRK13607 304 RIAKLLRKFQIVTGlSEEAMVEQGITSPFFPHGLGHPLGLQVHDVAGFMQDDRgthlAAPEKhPY---LRCTRVLEPGMV 380

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 665393932 413 VTIEPGCYFINWLMDRALADPNiAKFINAEMFNRFRNFGGVRIEDDVLITKTGVEN 468
Cdd:PRK13607 381 LTIEPGLYFIDSLLAPLREGPF-SKHFNWQKIDALKPFGGIRIEDNVVVHENGVEN 435
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 195-465 1.70e-39

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 141.88  E-value: 1.70e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 195 IEVLRYVAKVSSDAHIKVMRFMRPGRME----FEGESLFLHHaysvgGCRHASYTCICGSGTNSSILHyGHAGapnSKPV 270
Cdd:cd01092    1 IELLRKAARIADKAFEELLEFIKPGMTErevaAELEYFMRKL-----GAEGPSFDTIVASGPNSALPH-GVPS---DRKI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 271 QDGDLCLFDMGANYCGYAADITCTFpANGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLAGRVLlqrlkeggml 350
Cdd:cd01092   72 EEGDLVLIDFGAIYDGYCSDITRTV-AVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVI---------- 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 351 kgdveemLEAGVSGVFqPHGLGHLIGLDVHDvggylpkepkrpsEPWLSKlRFARILKAGMYVTIEPGCYFinwlmdral 430
Cdd:cd01092  141 -------EEAGYGEYF-IHRTGHGVGLEVHE-------------APYISP-GSDDVLEEGMVFTIEPGIYI--------- 189

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 665393932 431 adPniakfinaemfnrfrNFGGVRIEDDVLITKTG 465
Cdd:cd01092  190 --P---------------GKGGVRIEDDVLVTEDG 207
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 12-158 3.46e-35

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


Pssm-ID: 198079  Cd Length: 135  Bit Score: 127.74  E-value: 3.46e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932    12 VPMTLFRNNRDRagkaiLKELLPglkfnDGNLLVLLEGGKDQSlyNTDVDYVFRQESYFQYLFGVKEPGCYGILtiDVKT 91
Cdd:smart01011   1 IPAAEYAARRRR-----LAAKLF-----PGSVAVLPAGPEKVR--SNDTDYPFRQDSDFYYLTGFDEPDAVLVL--DPSG 66

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665393932    92 GAQKSVLFVPRFPDEYGTWMGELLGLQEFKAMYEVDEVFYVDEMSVYLEG--ASPKLILTLSGTNSDSG 158
Cdd:smart01011  67 GGGKSTLFVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGllAGAGTVYYLLGRDPDLD 135
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 195-465 3.25e-33

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 124.87  E-value: 3.25e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 195 IEVLRYVAKVSSDAHIKVMRFMRPGRMEFEGESLFLHHAYSVGGcrHASYTCICGSGTNSSILHYGhagaPNSKPVQDGD 274
Cdd:cd01066    1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGG--YPAGPTIVGSGARTALPHYR----PDDRRLQEGD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 275 LCLFDMGANYCGYAADITCTFPaNGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHKLAGRVllqrlkeggmlkgdv 354
Cdd:cd01066   75 LVLVDLGGVYDGYHADLTRTFV-IGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREV--------------- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 355 eeMLEAGVSGVFqPHGLGHLIGLDVHdvggylpkepkrpsEPWLSKLRFARILKAGMYVTIEPGCYFINWlmdraladpn 434
Cdd:cd01066  139 --LEEHGLGPNF-GHRTGHGIGLEIH--------------EPPVLKAGDDTVLEPGMVFAVEPGLYLPGG---------- 191

                        250       260       270
                 ....*....|....*....|....*....|.
gi 665393932 435 iakfinaemfnrfrnfGGVRIEDDVLITKTG 465
Cdd:cd01066  192 ----------------GGVRIEDTVLVTEDG 206
AMP_N pfam05195
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 17-139 1.04e-32

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families.


Pssm-ID: 461581 [Multi-domain]  Cd Length: 121  Bit Score: 120.69  E-value: 1.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932   17 FRNNRDRagkaiLKELLPGlkfndgNLLVLLEGGKDQSLYNtDVDYVFRQESYFQYLFGVKEPGCYGILT-IDVKTGaqK 95
Cdd:pfam05195   1 YAERRAR-----LLAKLPP------NSVAILPGAPEKYRNG-DVFYPFRQDSDFYYLTGFNEPDAVLVLEgGDIDSG--K 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 665393932   96 SVLFVPRFPDEYGTWMGELLGLQEFKAMYEVDEVFYVDEMSVYL 139
Cdd:pfam05195  67 ETLFVPPKDPEDEIWDGPRLGPEEAKELFGVDEVYPIDELDEVL 110
PRK09795 PRK09795
aminopeptidase; Provisional
 183-476 1.16e-24

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 105.02  E-value: 1.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 183 LSECRVIKSPEEIEVLRYVAKV--SSDAHIKvmRFMRPGRMEFEGES---LFLHHAysvgGCRHASYTCICGSGTNSSIL 257
Cdd:PRK09795 121 PDVLRQIKTPEEVEKIRLACGIadRGAEHIR--RFIQAGMSEREIAAeleWFMRQQ----GAEKASFDTIVASGWRGALP 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 258 HyghaGAPNSKPVQDGDLCLFDMGANYCGYAADITCTFPANGKFTDDQKF----IYNAVLDARNAVTESARDGVSWVDMH 333
Cdd:PRK09795 195 H----GKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESHplfnVYQIVLQAQLAAISAIRPGVRCQQVD 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 334 KLAGRVLlqrlkeggmlkgdveemLEAGVSGVFQpHGLGHLIGLDVHDVGGYLPKEPKRpsepwlsklrfariLKAGMYV 413
Cdd:PRK09795 271 DAARRVI-----------------TEAGYGDYFG-HNTGHAIGIEVHEDPRFSPRDTTT--------------LQPGMLL 318

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665393932 414 TIEPGCYfinwLMDRaladpniakfinaemfnrfrnfGGVRIEDDVLITKTGVENFAIVPRTV 476
Cdd:PRK09795 319 TVEPGIY----LPGQ----------------------GGVRIEDVVLVTPQGAEVLYAMPKTV 355
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 243-469 2.66e-13

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 69.13  E-value: 2.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 243 SYTCICGSGTNSSILHYgHAGAPNSKPVQDGDLCLFDMGANYCGYAADITCTFpANGKFTDDQKFIYNAVLDARNAVTeS 322
Cdd:cd01085   53 SFDTISGFGPNGAIVHY-SPTEESNRKISPDGLYLIDSGGQYLDGTTDITRTV-HLGEPTAEQKRDYTLVLKGHIALA-R 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 323 AR--DGVSWVDMHKLAGRVLLqrlkeggmlkgdvEEMLEAGvsgvfqpHGLGHLIG--LDVHDvggyLPKEPKRPSEPWl 398
Cdd:cd01085  130 AKfpKGTTGSQLDALARQPLW-------------KAGLDYG-------HGTGHGVGsfLNVHE----GPQSISPAPNNV- 184

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665393932 399 sklrfarILKAGMYVTIEPGCYfinwlmdraladpniakfiNAEMFnrfrnfgGVRIEDDVLITKTGVENF 469
Cdd:cd01085  185 -------PLKAGMILSNEPGYY-------------------KEGKY-------GIRIENLVLVVEAETTEF 222
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
189-296 1.86e-08

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 55.01  E-value: 1.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 189 IKSPEEIEVLRYVAKVSSDAHIKVMRFMRPGR--MEFE---GESLFLHHAYS----VGGCRHAsyTCICgsgTNSSILHy 259
Cdd:COG0024    3 IKTPEEIEKMREAGRIVAEVLDELAEAVKPGVttLELDriaEEFIRDHGAIPaflgYYGFPKS--ICTS---VNEVVVH- 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 665393932 260 ghaGAPNSKPVQDGDLCLFDMGANYCGYAADITCTFP 296
Cdd:COG0024   77 ---GIPSDRVLKDGDIVNIDVGAILDGYHGDSARTFV 110
PRK15173 PRK15173
peptidase; Provisional
 182-474 6.51e-06

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 48.17  E-value: 6.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 182 ILSECRVIKSPEEIEVLRYVAKVSSDAHIKVMRFMRPGRMEFEgeslfLHHAYSVGgcrhasytCICGSGTNSSILHYGH 261
Cdd:PRK15173  88 IFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAE-----LTAAYKAA--------VMSKSETHFSRFHLIS 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 262 AGA-------PNSKPVQDGDLCLFDMGANYCGYAADITCTFPAnGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHK 334
Cdd:PRK15173 155 VGAdfspkliPSNTKACSGDLIKFDCGVDVDGYGADIARTFVV-GEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFD 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 335 LAgrvlLQRLKEGGMLKGDVEEMleagvsgvfqPHGLGHLIGLDvhdvggylpkepkrpSEPWLSKlRFARILKAGMYVT 414
Cdd:PRK15173 234 ST----MEVIKKSGLPNYNRGHL----------GHGNGVFLGLE---------------ESPFVST-HATESFTSGMVLS 283

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 415 IEPGCYFInwlmdraladpniakfinaemfnrfrNFGGVRIEDDVLITKTGVENFAIVPR 474
Cdd:PRK15173 284 LETPYYGY--------------------------NLGSIMIEDMILINKEGIEFLSKLPR 317
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 188-467 7.81e-06

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 47.14  E-value: 7.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 188 VIKSPEEIEVLRYVAKVSSDAHIKVMRFMRPG------------RMEFEGeslflhhAY-SVGGCRH--ASyTCICgsgT 252
Cdd:PRK12896   9 EIKSPRELEKMRKIGRIVATALKEMGKAVEPGmttkeldriaekRLEEHG-------AIpSPEGYYGfpGS-TCIS---V 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 253 NSSILHyghaGAPNSKPVQDGDLCLFDMGANYCGYAADiTC-TFPAnGKFTDDqkfIYNAVLDARNAVTEsardGVSWVD 331
Cdd:PRK12896  78 NEEVAH----GIPGPRVIKDGDLVNIDVSAYLDGYHGD-TGiTFAV-GPVSEE---AEKLCRVAEEALWA----GIKQVK 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 332 mhklAGRVLLQrlkeggmLKGDVEEMLEA-GVSGV--FQPHGlghlIGLDVHDvggylpkEPK------RPSEpwlsklr 402
Cdd:PRK12896 145 ----AGRPLND-------IGRAIEDFAKKnGYSVVrdLTGHG----VGRSLHE-------EPSviltytDPLP------- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 403 fARILKAGMYVTIEPgcyFIN------------W---LMDRALAdpniakfinaemfnrfrnfggVRIEDDVLITKTGVE 467
Cdd:PRK12896 196 -NRLLRPGMTLAVEP---FLNlgakdaetlddgWtvvTPDKSLS---------------------AQFEHTVVVTRDGPE 250
PRK14575 PRK14575
putative peptidase; Provisional
 182-474 1.19e-05

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 47.39  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 182 ILSECRVIKSPEEIEVLRYVAKVSSDAHIKVMRFMRPGRMEFEgeslfLHHAYSVGgcrhasytCICGSGTNSSILHYGH 261
Cdd:PRK14575 171 IFNELRVIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAE-----LTAAYKAA--------VMSKSETHFSRFHLIS 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 262 AGA-------PNSKPVQDGDLCLFDMGANYCGYAADITCTFPAnGKFTDDQKFIYNAVLDARNAVTESARDGVSWVDMHK 334
Cdd:PRK14575 238 VGAdfspkliPSNTKACSGDLIKFDCGVDVDGYGADIARTFVV-GEPPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFD 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 335 LAgrvlLQRLKEGGMLKGDVEEMleagvsgvfqPHGLGHLIGLDvhdvggylpkepkrpSEPWLSKlRFARILKAGMYVT 414
Cdd:PRK14575 317 ST----MEVIKKSGLPNYNRGHL----------GHGNGVFLGLE---------------ESPFVST-HATESFTSGMVLS 366

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 415 IEPGCYFInwlmdraladpniakfinaemfnrfrNFGGVRIEDDVLITKTGVENFAIVPR 474
Cdd:PRK14575 367 LETPYYGY--------------------------NLGSIMIEDMILINKEGIEFLSKLPR 400
PRK14576 PRK14576
putative endopeptidase; Provisional
 182-295 8.56e-04

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 41.54  E-value: 8.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 182 ILSECRVIKSPEEIEVLRYVAKVSSDAHIKVMRFMRPGRMEFEGESLFLHHAYSVGGCRHASYTCIcGSGTNSSILHYgh 261
Cdd:PRK14576 170 LFNEIRMIKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVMSFPETNFSRFNLI-SVGDNFSPKII-- 246

                         90       100       110
                 ....*....|....*....|....*....|....
gi 665393932 262 agaPNSKPVQDGDLCLFDMGANYCGYAADITCTF 295
Cdd:PRK14576 247 ---ADTTPAKVGDLIKFDCGIDVAGYGADLARTF 277
PRK12318 PRK12318
methionyl aminopeptidase;
188-467 1.05e-03

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 40.96  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 188 VIKSPEEIEVLRYVAKVSSDAHIKVMRFMRPG--RMEFEGESLFLHHAYsvggcrHA-----SY------TCICGSgTNS 254
Cdd:PRK12318  42 IIKTPEQIEKIRKACQVTARILDALCEAAKEGvtTNELDELSRELHKEY------NAipaplNYgsppfpKTICTS-LNE 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 255 SILHyghaGAPNSKPVQDGDLCLFDMGANYCGYAADitCT-FPANGKFTDDQKFIYNAVLDARNAVTEsardgvswvdmh 333
Cdd:PRK12318 115 VICH----GIPNDIPLKNGDIMNIDVSCIVDGYYGD--CSrMVMIGEVSEIKKKVCQASLECLNAAIA------------ 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393932 334 klagrvllqRLKEGGMLKgDVEEMLEA-----GVSGVFQphGLGHLIGLDVHDvGGYLPKEPKRPSEPwlsklrfariLK 408
Cdd:PRK12318 177 ---------ILKPGIPLY-EIGEVIENcadkyGFSVVDQ--FVGHGVGIKFHE-NPYVPHHRNSSKIP----------LA 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 665393932 409 AGMYVTIEPgcyFINWLMDRALADPniakfINAEMFNRFRNFGGVRIEDDVLITKTGVE 467
Cdd:PRK12318 234 PGMIFTIEP---MINVGKKEGVIDP-----INHWEARTCDNQPSAQWEHTILITETGYE 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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