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Conserved domains on  [gi|664806049|ref|NP_001287742|]
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protein transport protein Sec24B isoform c [Homo sapiens]

Protein Classification

SEC24 family transport protein( domain architecture ID 1001573)

SEC24 family transport protein is a component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5028 super family cl34873
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 584-1289 0e+00

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5028:

Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 564.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  584 NCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLT----QLPVITSNTIVRCRSCRTYINPFVSFIDQ-RRWKCNL 658
Cdd:COG5028   147 NCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRCNI 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  659 CYRVNDVPEEFmYNPLTRS--YGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILCQSLLEN 736
Cdd:COG5028   227 CRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILEN 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  737 LDKLPG-DSRTRIGFMTFDSTIHFYNLQEGLSQpQMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNMFTNTR 814
Cdd:COG5028   306 LDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPsGLFVLPLKSCKQIIETLLDRVPRIFQDNK 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  815 ETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRsstkvvqHLGPATDFYKKLALDCSGQQTAVDL 894
Cdd:COG5028   385 SPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS-------LLSCKDSFYKEFAIECSKVGISVDL 457

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  895 FLLSSQYSDLASLACMSKYSAGCIYYYPSFHYThNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVR 974
Cdd:COG5028   458 FLTSEDYIDVATLSHLCRYTGGQTYFYPNFSAT-RPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNR 536

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  975 STDLLSLANINPDAGFAVQLSIEESLTdTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLAN 1054
Cdd:COG5028   537 SSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAK 615

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049 1055 MAVDRSVSSSLSDARDALVNAVVDSLSAY-GSTVSNLQHSALMAPSSLKLFPLYVLALLKQKAFRTGtSTRLDDRVYAMC 1133
Cdd:COG5028   616 KASTKALNSSLKEARVLINKSMVDILKAYkKELVKSNTSTQLPLPANLKLLPLLMLALLKSSAFRSG-STPSDIRISALN 694

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049 1134 QIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLqKLSAEKLTREGAFLMDCGSVFYIWVGKGCDNNFIEDV 1213
Cdd:COG5028   695 RLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVLPSPI-NATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDL 773

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 664806049 1214 LGYTNFASIPQKMTHLPELDTLSSERARSFITWLRDSRP-LSPILHIVKD--ESPAKAEFFQHLIEDRTEAAFSYYEFL 1289
Cdd:COG5028   774 FGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDdSTLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDYL 852
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 584-1289 0e+00

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 564.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  584 NCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLT----QLPVITSNTIVRCRSCRTYINPFVSFIDQ-RRWKCNL 658
Cdd:COG5028   147 NCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRCNI 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  659 CYRVNDVPEEFmYNPLTRS--YGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILCQSLLEN 736
Cdd:COG5028   227 CRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILEN 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  737 LDKLPG-DSRTRIGFMTFDSTIHFYNLQEGLSQpQMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNMFTNTR 814
Cdd:COG5028   306 LDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPsGLFVLPLKSCKQIIETLLDRVPRIFQDNK 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  815 ETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRsstkvvqHLGPATDFYKKLALDCSGQQTAVDL 894
Cdd:COG5028   385 SPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS-------LLSCKDSFYKEFAIECSKVGISVDL 457

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  895 FLLSSQYSDLASLACMSKYSAGCIYYYPSFHYThNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVR 974
Cdd:COG5028   458 FLTSEDYIDVATLSHLCRYTGGQTYFYPNFSAT-RPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNR 536

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  975 STDLLSLANINPDAGFAVQLSIEESLTdTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLAN 1054
Cdd:COG5028   537 SSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAK 615

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049 1055 MAVDRSVSSSLSDARDALVNAVVDSLSAY-GSTVSNLQHSALMAPSSLKLFPLYVLALLKQKAFRTGtSTRLDDRVYAMC 1133
Cdd:COG5028   616 KASTKALNSSLKEARVLINKSMVDILKAYkKELVKSNTSTQLPLPANLKLLPLLMLALLKSSAFRSG-STPSDIRISALN 694

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049 1134 QIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLqKLSAEKLTREGAFLMDCGSVFYIWVGKGCDNNFIEDV 1213
Cdd:COG5028   695 RLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVLPSPI-NATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDL 773

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 664806049 1214 LGYTNFASIPQKMTHLPELDTLSSERARSFITWLRDSRP-LSPILHIVKD--ESPAKAEFFQHLIEDRTEAAFSYYEFL 1289
Cdd:COG5028   774 FGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDdSTLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDYL 852
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 705-948 3.11e-131

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 402.42  E-value: 3.11e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  705 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGD-SRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLP 783
Cdd:cd01479     1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  784 TPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRS 863
Cdd:cd01479    81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  864 STKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHyTHNPSQAEKLQKDLKRY 943
Cdd:cd01479   161 TDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFN-FSAPNDVEKLVNELARY 239


                  ....*
gi 664806049  944 LTRKI 948
Cdd:cd01479   240 LTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 705-944 2.58e-107

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 338.07  E-value: 2.58e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049   705 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 784
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049   785 PDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLM--SPTGGRVSVFQTQLPSLGA-GLLQSREDPNQ 861
Cdd:pfam04811   81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049   862 RSSTKVVQHLGPATD-FYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYTHnpsQAEKLQKDL 940
Cdd:pfam04811  161 HGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237


                   ....
gi 664806049   941 KRYL 944
Cdd:pfam04811  238 QRYF 241
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 670-1298 1.51e-43

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 174.11  E-value: 1.51e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  670 MYNPLTRSYGEPHKRPEVQNSTVEFIASSDYMLrppqPAVYLFVLDVSHNAVEAGYLTILCQSL---LENLdKLPgdsRT 746
Cdd:PTZ00395  919 MKNLICEKNGEPDSAKIRRNSFLAKYPQVKNML----PPYFVFVVECSYNAIYNNITYTILEGIryaVQNV-KCP---QT 990

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  747 RIGFMTFDSTIHFYNLQEGLSQP-------------QMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNMFTN 812
Cdd:PTZ00395  991 KIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIKSVSTT 1070

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  813 TRETHSALGPALQAAFKLMSPTGG--RVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVQHLgpatdFYKKLALDCSGQQT 890
Cdd:PTZ00395 1071 MQSYGSCGNSALKIAMDMLKERNGlgSICMFYTTTPNCGIGAIKELKKDLQENFLEVKQKI-----FYDSLLLDLYAFNI 1145

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  891 AVDLFLLSSQYSDLA--SLACMSKYSAGCIYYYPSFHYthnpsqaeklQKDLKR-YL-------TRKIGFEAVMRIRCTK 960
Cdd:PTZ00395 1146 SVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENFLW----------QKDYKEiYMnimdtltSEDIAYCCELKLRYSH 1215

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  961 GLSMHTF---HGNF-FVRSTDLLSLANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSL 1036
Cdd:PTZ00395 1216 HMSVKKLfccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSL 1295

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049 1037 ADVYAGVDVQAaiclLANMAVDRSVSSSLSDarDALVNAVVDSLSA----YGSTVSNLQHSA-LMAPSSLKLFPLYVLAL 1111
Cdd:PTZ00395 1296 STVFRYTDAEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAilfsYRINCASSAHSGqLILPDTLKLLPLFTSSL 1369

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049 1112 LKQKAfrTGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLY--RIDRLTDE-GAVHVNDRIVPqPPLQKLSAEKLTREGA 1188
Cdd:PTZ00395 1370 LKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYviHIKGKTNEiDSMDVDDDLFI-PKTIPSSAEKIYSNGI 1446

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049 1189 FLMDCGSVFYIWVGKGCDNNFIEDVLGytnfaSIP-QKMTHLPEL-DTLSSERARSFItwlrdsRPLSPILH-------- 1258
Cdd:PTZ00395 1447 YLLDACTHFYLYFGFHSDANFAKEIVG-----DIPtEKNAHELNLtDTPNAQKVQRII------KNLSRIHHfnkyvplv 1515

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 664806049 1259 IVKDESPAKAEFFQHLIEDRTEAAFSYYEFLLHVQQQICK 1298
Cdd:PTZ00395 1516 MVAPKSNEEEHLISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 584-1289 0e+00

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 564.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  584 NCSPDSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLT----QLPVITSNTIVRCRSCRTYINPFVSFIDQ-RRWKCNL 658
Cdd:COG5028   147 NCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYpeedPVPLVEDGSIVRCRRCRSYINPFVQFIEQgRKWRCNI 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  659 CYRVNDVPEEFmYNPLTRS--YGEPHKRPEVQNSTVEFIASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTILCQSLLEN 736
Cdd:COG5028   227 CRSKNDVPEGF-DNPSGPNdpRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILEN 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  737 LDKLPG-DSRTRIGFMTFDSTIHFYNLQEGLSQpQMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNMFTNTR 814
Cdd:COG5028   306 LDQIPNfDPRTKIAIICFDSSLHFFKLSPDLDE-QMLIVSDLDEPFLPFPsGLFVLPLKSCKQIIETLLDRVPRIFQDNK 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  815 ETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRsstkvvqHLGPATDFYKKLALDCSGQQTAVDL 894
Cdd:COG5028   385 SPKNALGPALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLREDKESS-------LLSCKDSFYKEFAIECSKVGISVDL 457

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  895 FLLSSQYSDLASLACMSKYSAGCIYYYPSFHYThNPSQAEKLQKDLKRYLTRKIGFEAVMRIRCTKGLSMHTFHGNFFVR 974
Cdd:COG5028   458 FLTSEDYIDVATLSHLCRYTGGQTYFYPNFSAT-RPNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNR 536

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  975 STDLLSLANINPDAGFAVQLSIEESLTdTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSLADVYAGVDVQAAICLLAN 1054
Cdd:COG5028   537 SSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAK 615

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049 1055 MAVDRSVSSSLSDARDALVNAVVDSLSAY-GSTVSNLQHSALMAPSSLKLFPLYVLALLKQKAFRTGtSTRLDDRVYAMC 1133
Cdd:COG5028   616 KASTKALNSSLKEARVLINKSMVDILKAYkKELVKSNTSTQLPLPANLKLLPLLMLALLKSSAFRSG-STPSDIRISALN 694

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049 1134 QIKSQPLVHLMKMIHPNLYRIDRLTDEGAVHVNDRIVPQPPLqKLSAEKLTREGAFLMDCGSVFYIWVGKGCDNNFIEDV 1213
Cdd:COG5028   695 RLTSLPLKQLMRNIYPTLYALHDMPIEAGLPDEGLLVLPSPI-NATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDL 773

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 664806049 1214 LGYTNFASIPQKMTHLPELDTLSSERARSFITWLRDSRP-LSPILHIVKD--ESPAKAEFFQHLIEDRTEAAFSYYEFL 1289
Cdd:COG5028   774 FGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDdSTLPLVLVRGggDPSLRLWFFSTLVEDKTLNIPSYLDYL 852
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 705-948 3.11e-131

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 402.42  E-value: 3.11e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  705 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGD-SRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLP 783
Cdd:cd01479     1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  784 TPDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLMSPTGGRVSVFQTQLPSLGAGLLQSREDPNQRS 863
Cdd:cd01479    81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSREDPKLLS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  864 STKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHyTHNPSQAEKLQKDLKRY 943
Cdd:cd01479   161 TDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFN-FSAPNDVEKLVNELARY 239


                  ....*
gi 664806049  944 LTRKI 948
Cdd:cd01479   240 LTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 705-944 2.58e-107

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 338.07  E-value: 2.58e-107
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049   705 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 784
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049   785 PDSLLVNLYESKELIKDLLNALPNMFTNTRETHSALGPALQAAFKLM--SPTGGRVSVFQTQLPSLGA-GLLQSREDPNQ 861
Cdd:pfam04811   81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLkaAFTGGKIMVFQGGLPTVGPgGKLKSRLDESH 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049   862 RSSTKVVQHLGPATD-FYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYTHnpsQAEKLQKDL 940
Cdd:pfam04811  161 HGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADV---DGSKFKQDL 237


                   ....
gi 664806049   941 KRYL 944
Cdd:pfam04811  238 QRYF 241
trunk_domain cd01468
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ...
 705-942 1.21e-104

trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.


Pssm-ID: 238745 [Multi-domain]  Cd Length: 239  Bit Score: 330.75  E-value: 1.21e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  705 PQPAVYLFVLDVSHNAVEAGYLTILCQSLLENLDKLPGDSRTRIGFMTFDSTIHFYNLQEGLSQPQMLIVSDIDDVFLPT 784
Cdd:cd01468     1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPRARVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKDVFLPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  785 PDSLLVNLYESKELIKDLLNALPNMFTN--TRETHSALGPALQAAFKLMSPT--GGRVSVFQTQLPSLGAGLLQSREDPN 860
Cdd:cd01468    81 PDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTfaGGRIIVFQGGLPTVGPGKLKSREDKE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  861 QRSSTKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHYthnPSQAEKLQKDL 940
Cdd:cd01468   161 PIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQA---PNDGSKFKQDL 237


                  ..
gi 664806049  941 KR 942
Cdd:cd01468   238 QR 239
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 670-1298 1.51e-43

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 174.11  E-value: 1.51e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  670 MYNPLTRSYGEPHKRPEVQNSTVEFIASSDYMLrppqPAVYLFVLDVSHNAVEAGYLTILCQSL---LENLdKLPgdsRT 746
Cdd:PTZ00395  919 MKNLICEKNGEPDSAKIRRNSFLAKYPQVKNML----PPYFVFVVECSYNAIYNNITYTILEGIryaVQNV-KCP---QT 990

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  747 RIGFMTFDSTIHFYNLQEGLSQP-------------QMLIVSDIDDVFLPTP-DSLLVNLYESKELIKDLLNALPNMFTN 812
Cdd:PTZ00395  991 KIAIITFNSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIKSVSTT 1070

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  813 TRETHSALGPALQAAFKLMSPTGG--RVSVFQTQLPSLGAGLLQSREDPNQRSSTKVVQHLgpatdFYKKLALDCSGQQT 890
Cdd:PTZ00395 1071 MQSYGSCGNSALKIAMDMLKERNGlgSICMFYTTTPNCGIGAIKELKKDLQENFLEVKQKI-----FYDSLLLDLYAFNI 1145

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  891 AVDLFLLSSQYSDLA--SLACMSKYSAGCIYYYPSFHYthnpsqaeklQKDLKR-YL-------TRKIGFEAVMRIRCTK 960
Cdd:PTZ00395 1146 SVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVENFLW----------QKDYKEiYMnimdtltSEDIAYCCELKLRYSH 1215

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  961 GLSMHTF---HGNF-FVRSTDLLSLANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHTLCLPVVSSL 1036
Cdd:PTZ00395 1216 HMSVKKLfccNNNFnSIISVDTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSL 1295

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049 1037 ADVYAGVDVQAaiclLANMAVDRSVSSSLSDarDALVNAVVDSLSA----YGSTVSNLQHSA-LMAPSSLKLFPLYVLAL 1111
Cdd:PTZ00395 1296 STVFRYTDAEA----LMNILIKQLCTNILHN--DNYSKIIIDNLAAilfsYRINCASSAHSGqLILPDTLKLLPLFTSSL 1369

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049 1112 LKQKAfrTGTSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLY--RIDRLTDE-GAVHVNDRIVPqPPLQKLSAEKLTREGA 1188
Cdd:PTZ00395 1370 LKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYviHIKGKTNEiDSMDVDDDLFI-PKTIPSSAEKIYSNGI 1446

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049 1189 FLMDCGSVFYIWVGKGCDNNFIEDVLGytnfaSIP-QKMTHLPEL-DTLSSERARSFItwlrdsRPLSPILH-------- 1258
Cdd:PTZ00395 1447 YLLDACTHFYLYFGFHSDANFAKEIVG-----DIPtEKNAHELNLtDTPNAQKVQRII------KNLSRIHHfnkyvplv 1515

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|
gi 664806049 1259 IVKDESPAKAEFFQHLIEDRTEAAFSYYEFLLHVQQQICK 1298
Cdd:PTZ00395 1516 MVAPKSNEEEHLISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
Sec23_helical pfam04815
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ...
 1044-1145 2.18e-34

Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.


Pssm-ID: 461441 [Multi-domain]  Cd Length: 103  Bit Score: 127.23  E-value: 2.18e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  1044 DVQAAICLLANMAVDRSVSSSLSDARDALVNAVVDSLSAYGSTVSNLQHSA-LMAPSSLKLFPLYVLALLKQKAFRTGTS 1122
Cdd:pfam04815    1 DQEAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGqLILPESLKLLPLYMLALLKSPALRGGNS 80

                           90       100
                   ....*....|....*....|...
gi 664806049  1123 TRLDDRVYAMCQIKSQPLVHLMK 1145
Cdd:pfam04815   81 SPSDERAYARHLLLSLPVEELLL 103
Sec23_BS pfam08033
Sec23/Sec24 beta-sandwich domain;
949-1033 2.60e-32

Sec23/Sec24 beta-sandwich domain;


Pssm-ID: 429794 [Multi-domain]  Cd Length: 86  Bit Score: 120.72  E-value: 2.60e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049   949 GFEAVMRIRCTKGLSMHTFHGNFFVRS-TDLLSLANINPDAGFAVQLSIEESLTDTSLVCFQTALLYTSSKGERRIRVHT 1027
Cdd:pfam08033    1 GFNAVLRVRTSKGLKVSGFIGNFVSRSsGDTWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80


                   ....*.
gi 664806049  1028 LCLPVV 1033
Cdd:pfam08033   81 VALPVT 86
SEC23 COG5047
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
588-1204 4.00e-22

Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];


Pssm-ID: 227380 [Multi-domain]  Cd Length: 755  Bit Score: 103.42  E-value: 4.00e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  588 DSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIVRCRSCRTYINPFVSfIDQRR--WKCNLCYRVNDV 665
Cdd:COG5047    10 DGIRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYYEPVKCTAPCKAVLNPYCH-IDERNqsWICPFCNQRNTL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  666 PEEfmYNPLTRSYGEPhkRPEVQNSTVEFIASsdymlRPPQ-PAVYLFVLDVshnAVEAGYLTILCQSLLENLDKLPGDS 744
Cdd:COG5047    89 PPQ--YRDISNANLPL--ELLPQSSTIEYTLS-----KPVIlPPVFFFVVDA---CCDEEELTALKDSLIVSLSLLPPEA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  745 rtRIGFMTFDSTIHF----------------------YNLQE--GLSQPQMLIV--SDIDDVFLPTPDSLLVNLYESKEL 798
Cdd:COG5047   157 --LVGLITYGTSIQVhelnaenhrrsyvfsgnkeytkENLQEllALSKPTKSGGfeSKISGIGQFASSRFLLPTQQCEFK 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  799 IKDLLNAL-------PNMFTNTRETHSALGPA---LQAAFKLMsptGGRVSVFQTQLPSLGAGLLQSRE--DP---NQRS 863
Cdd:COG5047   235 LLNILEQLqpdpwpvPAGKRPLRCTGSALNIAsslLEQCFPNA---GCHIVLFAGGPCTVGPGTVVSTElkEPmrsHHDI 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  864 STKVVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFhythnpsQAEKLQKDLKRY 943
Cdd:COG5047   312 ESDSAQHSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSF-------TTSIFKQSFQRI 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  944 LTR------KIGFEAVMRIRCTKGLSMHTFHGN---------------FFVRSTDLLSLANINPDAGFAVQLSIEESLTD 1002
Cdd:COG5047   385 FNRdsegylKMGFNANMEVKTSKNLKIKGLIGHavsvkkkannisdseIGIGATNSWKMASLSPKSNYALYFEIALGAAS 464

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049 1003 TS-------LVCFQTalLYTSSKGERRIRVHTLCLPVVSSLADV-YAGVDVQAAICLLANMAVDRSVSSSLSDArDALVN 1074
Cdd:COG5047   465 GSaqrpaeaYIQFIT--TYQHSSGTYRIRVTTVARMFTDGGLPKiNRSFDQEAAAVFMARIAAFKAETEDIIDV-FRWID 541

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049 1075 AVVDSLSAYGSTVSNLQHSALMAPSSLKLFPLYVLALLKQKAFRTGtSTRLDDRVYAMCQIKSQPLVHLMKMIHPNLYRI 1154
Cdd:COG5047   542 RNLIRLCQKFADYRKDDPSSFRLDPNFTLYPQFMYHLRRSPFLSVF-NNSPDETAFYRHMLNNADVNDSLIMIQPTLQSY 620

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|
gi 664806049 1155 DRLTDEGAVHVnDRIVPQPPLQKLSAEKLTregaFLMDCGSVFYIWVGKG 1204
Cdd:COG5047   621 SFEKGGVPVLL-DSVSVKPDVILLLDTFFH----ILIFHGSYIAQWRNAG 665
zf-Sec23_Sec24 pfam04810
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 632-668 4.02e-16

Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.


Pssm-ID: 461437 [Multi-domain]  Cd Length: 38  Bit Score: 72.86  E-value: 4.02e-16
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 664806049   632 IVRCRSCRTYINPFVSFIDQ-RRWKCNLCYRVNDVPEE 668
Cdd:pfam04810    1 PVRCRRCRAYLNPFCQFDFGgKKWTCNFCGTRNPVPPE 38
PLN00162 PLN00162
transport protein sec23; Provisional
 588-1072 8.34e-14

transport protein sec23; Provisional


Pssm-ID: 215083 [Multi-domain]  Cd Length: 761  Bit Score: 76.13  E-value: 8.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  588 DSFRCTLTNIPQTQALLNKAKLPLGLLLHPFRDLTQLPVITSNTIvRCRSCRTYINPF--VSFiDQRRWKCNLCYRVNDV 665
Cdd:PLN00162   10 DGVRMSWNVWPSSKIEASKCVIPLAALYTPLKPLPELPVLPYDPL-RCRTCRAVLNPYcrVDF-QAKIWICPFCFQRNHF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  666 PeefmynpltRSY---GEPHKRPEV--QNSTVEFiASSDYMLRPPQPAVYLFVLDVSHNAVEAGYLTilcQSLLENLDKL 740
Cdd:PLN00162   88 P---------PHYssiSETNLPAELfpQYTTVEY-TLPPGSGGAPSPPVFVFVVDTCMIEEELGALK---SALLQAIALL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  741 PGDSrtRIGFMTFDSTIHFYNL------------------------QEGLS----QPQMLIVSDIDDVFLPTP-DSLLVN 791
Cdd:PLN00162  155 PENA--LVGLITFGTHVHVHELgfsecsksyvfrgnkevskdqileQLGLGgkkrRPAGGGIAGARDGLSSSGvNRFLLP 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  792 LYESKELIKDLLNALPNMFTNTRETHSAL---GPALQAAFKLM---SP-TGGRVSVFqTQLPS-LGAGLLQSREDPNQRS 863
Cdd:PLN00162  233 ASECEFTLNSALEELQKDPWPVPPGHRPArctGAALSVAAGLLgacVPgTGARIMAF-VGGPCtEGPGAIVSKDLSEPIR 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  864 STK-----VVQHLGPATDFYKKLALDCSGQQTAVDLFLLSSQYSDLASLACMSKYSAGCIYYYPSFHythnpsqAEKLQK 938
Cdd:PLN00162  312 SHKdldkdAAPYYKKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGGLVVLAESFG-------HSVFKD 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  939 DLKRYLTR------KIGFEAVMRIRCTKGL----------SMH----------TFHGNffvrsTDLLSLANINPDAGFAV 992
Cdd:PLN00162  385 SLRRVFERdgegslGLSFNGTFEVNCSKDVkvqgaigpcaSLEkkgpsvsdteIGEGG-----TTAWKLCGLDKKTSLAV 459

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806049  993 --QLSIEESLTDTSL---VCFQTALLYTSSKGERRIRVHTLCLPVV--SSLADVYAGVDVQAAICLLANMAVDRSVSssl 1065
Cdd:PLN00162  460 ffEVANSGQSNPQPPgqqFFLQFLTRYQHSNGQTRLRVTTVTRRWVegSSSEELVAGFDQEAAAVVMARLASHKMET--- 536


                  ....*..
gi 664806049 1066 SDARDAL 1072
Cdd:PLN00162  537 EEEFDAT 543
Gelsolin pfam00626
Gelsolin repeat;
1170-1244 3.27e-11

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 60.40  E-value: 3.27e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 664806049  1170 VPQPPLQKLSAEKLTREGAFLMDCGSVFYIWVGKGcdNNFIEDVLGYTNFASIP-QKMTHLPELDTLS-SERARSFI 1244
Cdd:pfam00626    2 FVLPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKG--SSLLEKLFAALLAAQLDdDERFPLPEVIRVPqGKEPARFL 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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