NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|664806041|ref|NP_001287761|]
View 

FERM domain-containing protein 8 isoform 2 [Homo sapiens]

Protein Classification

FERM_B-lobe and PH-like domain-containing protein( domain architecture ID 10448719)

FERM_B-lobe and PH-like domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FERM_M pfam00373
FERM central domain; This domain is the central structural domain of the FERM domain.
 80-216 6.22e-16

FERM central domain; This domain is the central structural domain of the FERM domain.


:

Pssm-ID: 459788 [Multi-domain]  Cd Length: 117  Bit Score: 73.46  E-value: 6.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806041   80 ELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDCEALGALVCRVQLGPYQPgrPAACDLREKLDSFLPAHLCKRGQSlfAA 159
Cdd:pfam00373   3 ELLLQDEVTRHLLYLQAKDDILEGRLPCSEEEALLLAALQLQAEFGDYQP--SSHTSEYLSLESFLPKQLLRKMKS--KE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 664806041  160 LRGRgaragpgeqgLLNAYRQVQEVSSDggcEAalgthYRAYLLKCHELPFYGCAFF 216
Cdd:pfam00373  79 LEKR----------VLEAHKNLRGLSAE---EA-----KLKYLQIAQSLPTYGVEFF 117
 
Name Accession Description Interval E-value
FERM_M pfam00373
FERM central domain; This domain is the central structural domain of the FERM domain.
 80-216 6.22e-16

FERM central domain; This domain is the central structural domain of the FERM domain.


Pssm-ID: 459788 [Multi-domain]  Cd Length: 117  Bit Score: 73.46  E-value: 6.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806041   80 ELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDCEALGALVCRVQLGPYQPgrPAACDLREKLDSFLPAHLCKRGQSlfAA 159
Cdd:pfam00373   3 ELLLQDEVTRHLLYLQAKDDILEGRLPCSEEEALLLAALQLQAEFGDYQP--SSHTSEYLSLESFLPKQLLRKMKS--KE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 664806041  160 LRGRgaragpgeqgLLNAYRQVQEVSSDggcEAalgthYRAYLLKCHELPFYGCAFF 216
Cdd:pfam00373  79 LEKR----------VLEAHKNLRGLSAE---EA-----KLKYLQIAQSLPTYGVEFF 117
B41 smart00295
Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in ...
 67-216 2.53e-10

Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in myosins, ezrin, radixin, moesin, protein tyrosine phosphatases. Plasma membrane-binding domain. These proteins play structural and regulatory roles in the assembly and stabilization of specialized plasmamembrane domains. Some PDZ domain containing proteins bind one or more of this family. Now includes JAKs.


Pssm-ID: 214604 [Multi-domain]  Cd Length: 201  Bit Score: 59.62  E-value: 2.53e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806041    67 LQFRRNvFFPKRRELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDCEALGALVCRVQLGPYQPGRPaACDLREKLDSFLP 146
Cdd:smart00295  74 LYFRVK-FYPPDPNQLKEDPTRLNLLYLQVRNDILEGRLPCPEEEALLLAALALQAEFGDYDEELH-DLRGELSLKRFLP 151

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806041   147 AHLCKRGQSLFAALRgrgaragpgeqgLLNAYRQVQEVSSDggcEAALgthyrAYLLKCHELPFYGCAFF 216
Cdd:smart00295 152 KQLLDSRKLKEWRER------------IVELHKELIGLSPE---EAKL-----KYLELARKLPTYGVELF 201
FERM_B-lobe cd14473
FERM domain B-lobe; The FERM domain has a cloverleaf tripart structure (FERM_N, FERM_M, FERM_C ...
 91-151 2.85e-06

FERM domain B-lobe; The FERM domain has a cloverleaf tripart structure (FERM_N, FERM_M, FERM_C/N, alpha-, and C-lobe/A-lobe, B-lobe, C-lobe/F1, F2, F3). The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases, the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains and consequently is capable of binding to both peptides and phospholipids at different sites.


Pssm-ID: 271216  Cd Length: 99  Bit Score: 45.32  E-value: 2.85e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 664806041  91 LLYEEAKGNVLAARYPCDVEDCEALGALVCRVQLGPYQPGRPAACDLreKLDSFLPAHLCK 151
Cdd:cd14473    4 LLYLQVKRDILEGRLPCSEETAALLAALALQAEYGDYDPSEHKPKYL--SLKRFLPKQLLK 62
 
Name Accession Description Interval E-value
FERM_M pfam00373
FERM central domain; This domain is the central structural domain of the FERM domain.
 80-216 6.22e-16

FERM central domain; This domain is the central structural domain of the FERM domain.


Pssm-ID: 459788 [Multi-domain]  Cd Length: 117  Bit Score: 73.46  E-value: 6.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806041   80 ELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDCEALGALVCRVQLGPYQPgrPAACDLREKLDSFLPAHLCKRGQSlfAA 159
Cdd:pfam00373   3 ELLLQDEVTRHLLYLQAKDDILEGRLPCSEEEALLLAALQLQAEFGDYQP--SSHTSEYLSLESFLPKQLLRKMKS--KE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 664806041  160 LRGRgaragpgeqgLLNAYRQVQEVSSDggcEAalgthYRAYLLKCHELPFYGCAFF 216
Cdd:pfam00373  79 LEKR----------VLEAHKNLRGLSAE---EA-----KLKYLQIAQSLPTYGVEFF 117
B41 smart00295
Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in ...
 67-216 2.53e-10

Band 4.1 homologues; Also known as ezrin/radixin/moesin (ERM) protein domains. Present in myosins, ezrin, radixin, moesin, protein tyrosine phosphatases. Plasma membrane-binding domain. These proteins play structural and regulatory roles in the assembly and stabilization of specialized plasmamembrane domains. Some PDZ domain containing proteins bind one or more of this family. Now includes JAKs.


Pssm-ID: 214604 [Multi-domain]  Cd Length: 201  Bit Score: 59.62  E-value: 2.53e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806041    67 LQFRRNvFFPKRRELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDCEALGALVCRVQLGPYQPGRPaACDLREKLDSFLP 146
Cdd:smart00295  74 LYFRVK-FYPPDPNQLKEDPTRLNLLYLQVRNDILEGRLPCPEEEALLLAALALQAEFGDYDEELH-DLRGELSLKRFLP 151

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 664806041   147 AHLCKRGQSLFAALRgrgaragpgeqgLLNAYRQVQEVSSDggcEAALgthyrAYLLKCHELPFYGCAFF 216
Cdd:smart00295 152 KQLLDSRKLKEWRER------------IVELHKELIGLSPE---EAKL-----KYLELARKLPTYGVELF 201
FERM_B-lobe cd14473
FERM domain B-lobe; The FERM domain has a cloverleaf tripart structure (FERM_N, FERM_M, FERM_C ...
 91-151 2.85e-06

FERM domain B-lobe; The FERM domain has a cloverleaf tripart structure (FERM_N, FERM_M, FERM_C/N, alpha-, and C-lobe/A-lobe, B-lobe, C-lobe/F1, F2, F3). The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases, the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains and consequently is capable of binding to both peptides and phospholipids at different sites.


Pssm-ID: 271216  Cd Length: 99  Bit Score: 45.32  E-value: 2.85e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 664806041  91 LLYEEAKGNVLAARYPCDVEDCEALGALVCRVQLGPYQPGRPAACDLreKLDSFLPAHLCK 151
Cdd:cd14473    4 LLYLQVKRDILEGRLPCSEETAALLAALALQAEYGDYDPSEHKPKYL--SLKRFLPKQLLK 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH