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Conserved domains on  [gi|688955083|ref|NP_001288799|]
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peptide chain release factor 1-like, mitochondrial isoform 2 [Homo sapiens]

Protein Classification

peptide chain release factor 1( domain architecture ID 1907968)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

CATH:  3.30.160.20|3.30.70.1660|1.10.287.4000
Gene Ontology:  GO:0003747|GO:0016149
SCOP:  4002864|4002570

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA super family cl43066
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 63-330 6.59e-133

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


The actual alignment was detected with superfamily member COG0216:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 382.81  E-value: 6.59e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  63 ELLAVIKLLNEKERELRETEHLLHDEN-EDLRKLAENEITLCQKEITQLKHQIILLLVPSEETDENDLILEVTAGVGG-- 139
Cdd:COG0216   44 PIVEAYREYKKLLEDIEEAKELLEEESdPEMREMAKEELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGde 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 140 ----------------------------------GLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTV 185
Cdd:COG0216  124 aalfagdlfrmysryaerkgwkveilsasegelgGYKEVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATV 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 186 AILPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLE 265
Cdd:COG0216  204 AVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQ 283

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688955083 266 EEINKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQSLKEY 330
Cdd:COG0216  284 KQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDALIAE 346
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 63-330 6.59e-133

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 382.81  E-value: 6.59e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  63 ELLAVIKLLNEKERELRETEHLLHDEN-EDLRKLAENEITLCQKEITQLKHQIILLLVPSEETDENDLILEVTAGVGG-- 139
Cdd:COG0216   44 PIVEAYREYKKLLEDIEEAKELLEEESdPEMREMAKEELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGde 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 140 ----------------------------------GLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTV 185
Cdd:COG0216  124 aalfagdlfrmysryaerkgwkveilsasegelgGYKEVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATV 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 186 AILPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLE 265
Cdd:COG0216  204 AVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQ 283

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688955083 266 EEINKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQSLKEY 330
Cdd:COG0216  284 KQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDALIAE 346
prfA PRK00591
peptide chain release factor 1; Validated
 63-327 8.61e-128

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 369.79  E-value: 8.61e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  63 ELLAVIKLLNEKERELRETEHLLHDEN-EDLRKLAENEITLCQKEITQLKHQIILLLVPSEETDENDLILEVTAGVGG-- 139
Cdd:PRK00591  46 PIVEAYREYKQAQEDLEEAKEMLEEESdPEMREMAKEELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGde 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 140 ----------------------------------GLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTV 185
Cdd:PRK00591 126 aalfagdlfrmysryaerqgwkveilsasegelgGYKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATV 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 186 AILPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLE 265
Cdd:PRK00591 206 AVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQ 285

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688955083 266 EEINKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQSL 327
Cdd:PRK00591 286 KAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDAL 345
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 60-342 7.42e-112

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 329.35  E-value: 7.42e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083   60 RRPELLAVIKLLNEKER---ELRETEHLLHDENEDLRKLAENEITLCQKEITQLKHQIILLLVPSEETDENDLILEVTAG 136
Cdd:TIGR00019  41 EYSQLEEIVDCYREYQQaqeDIKEAKEILEESDPEMREMAKEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAG 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  137 VGG------------------------------------GLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHT 180
Cdd:TIGR00019 121 TGGdeaaifagdlfrmysryaeskgwkveilsanetelgGYKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHT 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  181 STMTVAILPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLY 260
Cdd:TIGR00019 201 SAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLY 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  261 SMHLEEEINKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQSLKEYADYESLVEII 340
Cdd:TIGR00019 281 EAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHRINLTLYKLDEVLEGD--LDELIEALIAEDQAQQLAALS 358


                  ..
gi 688955083  341 SQ 342
Cdd:TIGR00019 359 EE 360
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 193-302 4.94e-58

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 183.01  E-value: 4.94e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  193 EINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEEINKRQ 272
Cdd:pfam00472   2 EIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKKR 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 688955083  273 NARKiQIGSKGRSEKIRTYNF-PQNRVTDHR 302
Cdd:pfam00472  82 RIKS-QVGSGDRSEQIRTYNFkPQSRVKDHR 111
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 63-330 6.59e-133

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 382.81  E-value: 6.59e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  63 ELLAVIKLLNEKERELRETEHLLHDEN-EDLRKLAENEITLCQKEITQLKHQIILLLVPSEETDENDLILEVTAGVGG-- 139
Cdd:COG0216   44 PIVEAYREYKKLLEDIEEAKELLEEESdPEMREMAKEELEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGde 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 140 ----------------------------------GLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTV 185
Cdd:COG0216  124 aalfagdlfrmysryaerkgwkveilsasegelgGYKEVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATV 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 186 AILPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLE 265
Cdd:COG0216  204 AVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQ 283

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688955083 266 EEINKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQSLKEY 330
Cdd:COG0216  284 KQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDALIAE 346
prfA PRK00591
peptide chain release factor 1; Validated
 63-327 8.61e-128

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 369.79  E-value: 8.61e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  63 ELLAVIKLLNEKERELRETEHLLHDEN-EDLRKLAENEITLCQKEITQLKHQIILLLVPSEETDENDLILEVTAGVGG-- 139
Cdd:PRK00591  46 PIVEAYREYKQAQEDLEEAKEMLEEESdPEMREMAKEELKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGde 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 140 ----------------------------------GLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTV 185
Cdd:PRK00591 126 aalfagdlfrmysryaerqgwkveilsasegelgGYKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATV 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 186 AILPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLE 265
Cdd:PRK00591 206 AVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQ 285

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688955083 266 EEINKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQSL 327
Cdd:PRK00591 286 KAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDAL 345
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 60-342 7.42e-112

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 329.35  E-value: 7.42e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083   60 RRPELLAVIKLLNEKER---ELRETEHLLHDENEDLRKLAENEITLCQKEITQLKHQIILLLVPSEETDENDLILEVTAG 136
Cdd:TIGR00019  41 EYSQLEEIVDCYREYQQaqeDIKEAKEILEESDPEMREMAKEELEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAG 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  137 VGG------------------------------------GLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHT 180
Cdd:TIGR00019 121 TGGdeaaifagdlfrmysryaeskgwkveilsanetelgGYKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHT 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  181 STMTVAILPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLY 260
Cdd:TIGR00019 201 SAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLY 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  261 SMHLEEEINKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQSLKEYADYESLVEII 340
Cdd:TIGR00019 281 EAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHRINLTLYKLDEVLEGD--LDELIEALIAEDQAQQLAALS 358


                  ..
gi 688955083  341 SQ 342
Cdd:TIGR00019 359 EE 360
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 58-326 5.83e-59

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 194.22  E-value: 5.83e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083   58 KVRRPELLAVIKLLNEKERELRETEHLLHDEN-EDLRKLAENEITLCQKEITQLKHQIILllvpSEETDENDLILEVTAG 136
Cdd:TIGR00020  58 RSSLEAVLDTLEELKNSLEDLSELLELAVEEDdEETFNELDAELKALEKKLAELELRTML----SGEYDANNAYLTIQAG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  137 VGG------------------------------------GLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHT 180
Cdd:TIGR00020 134 AGGteaqdwasmlyrmylrwaerrgfkveiidysegeeaGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHT 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  181 STMTVAILPQPTE-INLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKL 259
Cdd:TIGR00020 214 SFASVFVMPEVDDdIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKL 293

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688955083  260 YSMHLEEEINKRQNARKIQIGSkGRSEKIRTYNF-PQNRVTDHRINKTLHDLETFMQGDylLDELVQS 326
Cdd:TIGR00020 294 YELEMEKEQAEKDAKEGEKSEI-GWGSQIRSYVLhPYSMVKDLRTGYETGNVQAVLDGD--IDQFIEA 358
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 193-302 4.94e-58

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 183.01  E-value: 4.94e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  193 EINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEEINKRQ 272
Cdd:pfam00472   2 EIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKKR 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 688955083  273 NARKiQIGSKGRSEKIRTYNF-PQNRVTDHR 302
Cdd:pfam00472  82 RIKS-QVGSGDRSEQIRTYNFkPQSRVKDHR 111
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 71-317 6.09e-50

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 169.60  E-value: 6.09e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  71 LNEKERELRETEHLLHDENEDLRKLAENEITLCQKEITQLKHQIILllvpSEETDENDLILEVTAGVGG----------- 139
Cdd:PRK05589  33 LRNRIEDIEVLCEMMSEEDDEMKKEIISEVKNIKEEIDRFKIETLL----SGEYDRNNAILTLHSGVGGtdaqdwtemll 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 140 -------------------------GLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAILPQPT-E 193
Cdd:PRK05589 109 rmytrwaekkgykveiidllegdeaGIKSVTLKITGEFAYGYLKAEKGIHRLVRISPFNANGKRQTSFASVEVLPELTdD 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 194 INLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYsmhleeEINKRQN 273
Cdd:PRK05589 189 QDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAMKMLKSKLV------ELKERAH 262

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 688955083 274 ARKIQ-----IGSKGRSEKIRTYNF-PQNRVTDHRINKTLHDLETFMQGD 317
Cdd:PRK05589 263 KEKIEdltgeLKDMGWGSQIRSYVFhPYNLVKDHRTGVETSNVDSVMDGD 312
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 130-328 8.67e-47

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 160.98  E-value: 8.67e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 130 ILEVTAGVGGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAILPQPTE-INLVINPKDLRIDTK 208
Cdd:PRK08787 104 LMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFVSPEVDDnIEIDINPADLRTDVY 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 209 RASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYsmhlEEEINKRQNARKIQIGSK---GRS 285
Cdd:PRK08787 184 RSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLY----ELEVQKRNAEKDALEATKsdiGWG 259

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 688955083 286 EKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQ-SLK 328
Cdd:PRK08787 260 SQIRNYVLDQSRIKDLRTGIERSDTQKVLDGD--LDEFVEaSLK 301
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 53-326 1.72e-46

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 160.81  E-value: 1.72e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  53 SEAHLKVR-RPELLAVIKLLNEKERELRETEHLL----HDENEDLRKLAENEITLCQKEITqlKHQIILLLvpSEETDEN 127
Cdd:PRK07342  13 QEAQKLMReRQQLDDSINGINHLEQTLNDNIELIamgeEEGDKSIVEDAEKTIRDLKDEID--RRQIDALL--SGEADAN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 128 DLILEVTAGVGG------------------------------------GLRHASASIGGSEAYRHMKFEGGVHRVQRVPK 171
Cdd:PRK07342  89 DTYLEVHAGAGGtesqdwasmllrmytrwaerqgrkvevlevhdgeeaGIKSATILVKGHNAYGWLKTESGVHRLVRISP 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 172 TEKQGRVHTSTMTVAILPQPTE-INLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKEL 250
Cdd:PRK07342 169 YDSNARRHTSFASIWVYPVIDDnIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKNRAK 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 251 AMTKLRAKLYsmhlEEEINKRQNARKIQIGSK---GRSEKIRTYNF-PQNRVTDHRINKTLHDLETFMQGDylLDELVQS 326
Cdd:PRK07342 249 AWSMLRARLY----EEELKKREEATNAAAASKtdiGWGHQIRSYVLqPYQLVKDLRTGVESTNPQDVLDGD--LNEFMEA 322
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 46-326 8.34e-46

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 158.74  E-value: 8.34e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083  46 FLERQAGSEAHLKVRRP--ELLAVIKLLNEKERELRETEHLLHDE-NEDLRKLAENEITLCQKEITQLKHQIILllvpSE 122
Cdd:PRK06746   6 FWDDQQGAQAVINEANAlkDMVGKFRQLDETFENLEITHELLKEEyDEDLHEELESEVKGLIQEMNEYELQLLL----SD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 123 ETDENDLILEVTAGVGG------------------------------------GLRHASASIGGSEAYRHMKFEGGVHRV 166
Cdd:PRK06746  82 PYDKNNAILELHPGAGGtesqdwgsmllrmytrwaekrgfkvetvdylpgdeaGIKSVTLLIKGHNAYGYLKAEKGVHRL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 167 QRVPKTEKQGRVHTSTMTVAILPQ-PTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQL 245
Cdd:PRK06746 162 VRISPFDSSGRRHTSFVSCEVVPEfNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 246 KNKELAMTKLRAKLYSMHLEEEINKRQNARKIQiGSKGRSEKIRTYNF-PQNRVTDHRINKTLHDLETFMQG--DYLLDE 322
Cdd:PRK06746 242 KNREHAMKMLKAKLYQKKLEEQQAELDEIRGEQ-KEIGWGSQIRSYVFhPYSLVKDHRTNTEVGNVQAVMDGeiDPFIDA 320


                 ....
gi 688955083 323 LVQS 326
Cdd:PRK06746 321 YLRS 324
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 63-185 1.60e-39

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 138.29  E-value: 1.60e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083   63 ELLAVIKLLNEKERELRETEHLLHDEneDLRKLAENEITLCQKEITQLKHQIILLLVPSEETDENDLILEVTAGVGG--- 139
Cdd:pfam03462  36 PIVEAYREYKQALEDLEEAKELLEDP--ELAELAEEELEELEKRLEELEEELKLLLLPKDPNDDKNAILEIRAGAGGdea 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 688955083  140 ---------------------------------GLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTV 185
Cdd:pfam03462 114 alfagdlfrmytryaerkgwkvevldyseteagGIKEATFEISGEGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 195-302 2.89e-33

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 120.24  E-value: 2.89e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 195 NLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVH------------LPTGVVSECQQERSQLKNKELAMTKLRAKLYSM 262
Cdd:COG1186   20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 688955083 263 HLEEeinKRQNARKIQIGSKGR---SEKIRtynfpqNRVTDHR 302
Cdd:COG1186  100 ELEP---KERRATKPTRGSKKRrlwGKQIR------SMVKDLR 133
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 198-275 3.16e-20

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 87.13  E-value: 3.16e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688955083  198 INPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEEINKRQNAR 275
Cdd:TIGR03072 103 ATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLATLLLAVRLADLQQEQAAALRAERR 180
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
195-257 9.03e-10

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 56.31  E-value: 9.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955083 195 NLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIV------HLPT-----------------GVVS-ECQQERSQLKNKEL 250
Cdd:PRK09256   7 RLVIPENELEWRFIRASGPGGQNVNKVSTAVELRfdiaasSLPEfykerllalaghritkdGVIViKAQEFRSQERNRED 86


                 ....*..
gi 688955083 251 AMTKLRA 257
Cdd:PRK09256  87 ALERLVA 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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