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Conserved domains on  [gi|688955163|ref|NP_001288800|]
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peptide chain release factor 1-like, mitochondrial isoform 4 [Homo sapiens]

Protein Classification

peptide chain release factor 1( domain architecture ID 1907968)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

CATH:  3.30.160.20|3.30.70.1660|1.10.287.4000
Gene Ontology:  GO:0003747|GO:0016149
SCOP:  4002864|4002570

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA super family cl43066
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 2-224 1.04e-135

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


The actual alignment was detected with superfamily member COG0216:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 385.51  E-value: 1.04e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163   2 LFTSEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAI 81
Cdd:COG0216  126 LFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAV 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163  82 LPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEE 161
Cdd:COG0216  206 LPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQ 285

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 688955163 162 INKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQSLKEY 224
Cdd:COG0216  286 QAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDALIAE 346
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 2-224 1.04e-135

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 385.51  E-value: 1.04e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163   2 LFTSEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAI 81
Cdd:COG0216  126 LFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAV 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163  82 LPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEE 161
Cdd:COG0216  206 LPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQ 285

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 688955163 162 INKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQSLKEY 224
Cdd:COG0216  286 QAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDALIAE 346
prfA PRK00591
peptide chain release factor 1; Validated
 2-221 9.91e-131

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 372.87  E-value: 9.91e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163   2 LFTSEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAI 81
Cdd:PRK00591 128 LFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAV 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163  82 LPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEE 161
Cdd:PRK00591 208 LPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKA 287

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163 162 INKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQSL 221
Cdd:PRK00591 288 QAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDAL 345
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 2-236 1.53e-112

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 327.04  E-value: 1.53e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163    2 LFTSEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAI 81
Cdd:TIGR00019 128 IFAGDLFRMYSRYAESKGWKVEILSANETELGGYKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAV 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163   82 LPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEE 161
Cdd:TIGR00019 208 MPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQ 287

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688955163  162 INKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQSLKEYADYESLVEIISQ 236
Cdd:TIGR00019 288 QAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHRINLTLYKLDEVLEGD--LDELIEALIAEDQAQQLAALSEE 360
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 87-196 4.52e-60

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 184.55  E-value: 4.52e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163   87 EINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEEINKRQ 166
Cdd:pfam00472   2 EIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKKR 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 688955163  167 NARKiQIGSKGRSEKIRTYNF-PQNRVTDHR 196
Cdd:pfam00472  82 RIKS-QVGSGDRSEQIRTYNFkPQSRVKDHR 111
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 2-224 1.04e-135

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 385.51  E-value: 1.04e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163   2 LFTSEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAI 81
Cdd:COG0216  126 LFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAV 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163  82 LPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEE 161
Cdd:COG0216  206 LPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQ 285

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 688955163 162 INKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQSLKEY 224
Cdd:COG0216  286 QAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDALIAE 346
prfA PRK00591
peptide chain release factor 1; Validated
 2-221 9.91e-131

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 372.87  E-value: 9.91e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163   2 LFTSEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAI 81
Cdd:PRK00591 128 LFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKEVIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAV 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163  82 LPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEE 161
Cdd:PRK00591 208 LPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKA 287

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163 162 INKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQSL 221
Cdd:PRK00591 288 QAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEVMEGD--LDELIDAL 345
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 2-236 1.53e-112

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 327.04  E-value: 1.53e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163    2 LFTSEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAI 81
Cdd:TIGR00019 128 IFAGDLFRMYSRYAESKGWKVEILSANETELGGYKEVIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAV 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163   82 LPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEE 161
Cdd:TIGR00019 208 MPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQ 287

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 688955163  162 INKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQSLKEYADYESLVEIISQ 236
Cdd:TIGR00019 288 QAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHRINLTLYKLDEVLEGD--LDELIEALIAEDQAQQLAALSEE 360
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 5-220 1.36e-61

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 196.92  E-value: 1.36e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163    5 SEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAILPQ 84
Cdd:TIGR00020 144 SMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPE 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163   85 PTE-INLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEEIN 163
Cdd:TIGR00020 224 VDDdIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQA 303

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 688955163  164 KRQNARKIQIGSkGRSEKIRTYNF-PQNRVTDHRINKTLHDLETFMQGDylLDELVQS 220
Cdd:TIGR00020 304 EKDAKEGEKSEI-GWGSQIRSYVLhPYSMVKDLRTGYETGNVQAVLDGD--IDQFIEA 358
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 87-196 4.52e-60

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 184.55  E-value: 4.52e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163   87 EINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEEINKRQ 166
Cdd:pfam00472   2 EIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKKR 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 688955163  167 NARKiQIGSKGRSEKIRTYNF-PQNRVTDHR 196
Cdd:pfam00472  82 RIKS-QVGSGDRSEQIRTYNFkPQSRVKDHR 111
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 3-211 2.13e-51

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 169.60  E-value: 2.13e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163   3 FTSEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAIL 82
Cdd:PRK05589 103 WTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLVRISPFNANGKRQTSFASVEVL 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163  83 PQPT-EINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYsmhleeE 161
Cdd:PRK05589 183 PELTdDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAMKMLKSKLV------E 256

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 688955163 162 INKRQNARKIQ-----IGSKGRSEKIRTYNF-PQNRVTDHRINKTLHDLETFMQGD 211
Cdd:PRK05589 257 LKERAHKEKIEdltgeLKDMGWGSQIRSYVFhPYNLVKDHRTGVETSNVDSVMDGD 312
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 10-222 3.51e-51

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 168.68  E-value: 3.51e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163  10 MYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAILPQPTE-I 88
Cdd:PRK08787  90 MYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFVSPEVDDnI 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163  89 NLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYsmhlEEEINKRQNA 168
Cdd:PRK08787 170 EIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLY----ELEVQKRNAE 245

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 688955163 169 RKIQIGSK---GRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDylLDELVQ-SLK 222
Cdd:PRK08787 246 KDALEATKsdiGWGSQIRNYVLDQSRIKDLRTGIERSDTQKVLDGD--LDEFVEaSLK 301
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 10-220 1.01e-48

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 163.13  E-value: 1.01e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163  10 MYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAILPQPTE-I 88
Cdd:PRK07342 113 MYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESGVHRLVRISPYDSNARRHTSFASIWVYPVIDDnI 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163  89 NLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYsmhlEEEINKRQNA 168
Cdd:PRK07342 193 EVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKNRAKAWSMLRARLY----EEELKKREEA 268

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 688955163 169 RKIQIGSK---GRSEKIRTYNF-PQNRVTDHRINKTLHDLETFMQGDylLDELVQS 220
Cdd:PRK07342 269 TNAAAASKtdiGWGHQIRSYVLqPYQLVKDLRTGVESTNPQDVLDGD--LNEFMEA 322
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 5-220 1.66e-48

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 162.21  E-value: 1.66e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163   5 SEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAILPQ 84
Cdd:PRK06746 106 SMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVSCEVVPE 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163  85 -PTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEEIN 163
Cdd:PRK06746 186 fNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAKLYQKKLEEQQA 265

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163 164 KRQNARKIQiGSKGRSEKIRTYNF-PQNRVTDHRINKTLHDLETFMQG--DYLLDELVQS 220
Cdd:PRK06746 266 ELDEIRGEQ-KEIGWGSQIRSYVFhPYSLVKDHRTNTEVGNVQAVMDGeiDPFIDAYLRS 324
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 1-79 5.52e-39

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 133.66  E-value: 5.52e-39
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 688955163    1 MLFTSEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTV 79
Cdd:pfam03462 114 ALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISGEGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 89-203 8.71e-36

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 123.70  E-value: 8.71e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163  89 NLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVH------------LPTGVVSECQQERSQLKNKELAMTKLRAKLYSM 156
Cdd:COG1186   20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 688955163 157 HLEEeinKRQNARKIQIGSKGR---SEKIRtynfpqNRVTDHRINKTLHD 203
Cdd:COG1186  100 ELEP---KERRATKPTRGSKKRrlwGKQIR------SMVKDLRGNVDDGD 140
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 92-169 3.85e-22

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 90.22  E-value: 3.85e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688955163   92 INPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEEINKRQNAR 169
Cdd:TIGR03072 103 ATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANKRLATLLLAVRLADLQQEQAAALRAERR 180
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
89-151 3.15e-11

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 59.40  E-value: 3.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163  89 NLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIV------HLPT-----------------GVVS-ECQQERSQLKNKEL 144
Cdd:PRK09256   7 RLVIPENELEWRFIRASGPGGQNVNKVSTAVELRfdiaasSLPEfykerllalaghritkdGVIViKAQEFRSQERNRED 86


                 ....*..
gi 688955163 145 AMTKLRA 151
Cdd:PRK09256  87 ALERLVA 93
EssA pfam10661
WXG100 protein secretion system (Wss), protein EssA; The WXG100 protein secretion system (Wss) ...
 131-232 8.00e-03

WXG100 protein secretion system (Wss), protein EssA; The WXG100 protein secretion system (Wss) is responsible for the secretion of WXG100 proteins (pfam06013) such as ESAT-6 and CFP-10 in Mycobacterium tuberculosis or EsxA and EsxB in Staphylococcus aureus. In S. aureus, the Wss seems to be encoded by a locus of eight CDS, called ess (eSAT-6 secretion system). This locus encodes, amongst several other proteins, EssA, a protein predicted to possess one transmembrane domain. Due to its predicted membrane location and its absolute requirement for WXG100 protein secretion, it has been speculated that EssA could form a secretion apparatus in conjunction with the polytopic membrane protein EsaA, YukC (pfam10140) and YukAB, which is a membrane-bound ATPase containing Ftsk/SpoIIIE domains (pfam01580) called EssC in S. aureus and Snm1/Snm2 in Mycobacterium tuberculosis. Proteins homologous to EssA, YukC, EsaA and YukD seem absent from mycobacteria.


Pssm-ID: 287614  Cd Length: 148  Bit Score: 35.63  E-value: 8.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688955163  131 ECQQERSQLKNKELAMTKLRAKLYSMHLEEEINKRQNARKIQIgskgrsEKIRTYNFPQNRVTDHRINKTlhdLETFMQG 210
Cdd:pfam10661  24 KDKQEKNEKQLRETELDKAFISLFTTETEEEINEKKKAEKKEM------EDIEDSLFSEDKEGNVAVKDT---KDSLFSS 94

                          90       100
                  ....*....|....*....|..
gi 688955163  211 DYlldELVQSLKEYADYESLVE 232
Cdd:pfam10661  95 EY---EVRASNTETASSETAEE 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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