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Conserved domains on  [gi|756761766|ref|NP_001291929|]
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mediator of RNA polymerase II transcription subunit 11 isoform b [Homo sapiens]

Protein Classification

mediator of RNA polymerase II transcription subunit 11 family protein( domain architecture ID 4910)

mediator of RNA polymerase II transcription subunit 11 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Gene Ontology:  GO:0061629|GO:0016592
PubMed:  15175151|16263706

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med11 super family cl10960
Mediator complex protein; Mediator is a large, modular protein complex that is conserved from ...
 8-72 1.96e-12

Mediator complex protein; Mediator is a large, modular protein complex that is conserved from yeast to human and conveys regulatory signals from DNA-binding transcription factors to RNA polymerase II. Not only are the polypeptides conserved but the structural organization is also largely conserved. One or two subunits are either fungal or vertebral specific but Med11 is one of the subunits that is conserved from fungi to humans. Med11 appears to be necessary for the full and successful assembly of the core head sub-region.


The actual alignment was detected with superfamily member pfam10280:

Pssm-ID: 463042  Cd Length: 119  Bit Score: 57.64  E-value: 1.96e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 756761766    8 NERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTA-------SVQHVEAELSAQIRYLTQ 72
Cdd:pfam10280   1 AERIQQLNEIDKDIVSLLQSASTAIQALSNSPSPSESLEARKEAFKAatsqfysTLSSVDVRLRRQIKALEE 72
 
Name Accession Description Interval E-value
Med11 pfam10280
Mediator complex protein; Mediator is a large, modular protein complex that is conserved from ...
 8-72 1.96e-12

Mediator complex protein; Mediator is a large, modular protein complex that is conserved from yeast to human and conveys regulatory signals from DNA-binding transcription factors to RNA polymerase II. Not only are the polypeptides conserved but the structural organization is also largely conserved. One or two subunits are either fungal or vertebral specific but Med11 is one of the subunits that is conserved from fungi to humans. Med11 appears to be necessary for the full and successful assembly of the core head sub-region.


Pssm-ID: 463042  Cd Length: 119  Bit Score: 57.64  E-value: 1.96e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 756761766    8 NERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTA-------SVQHVEAELSAQIRYLTQ 72
Cdd:pfam10280   1 AERIQQLNEIDKDIVSLLQSASTAIQALSNSPSPSESLEARKEAFKAatsqfysTLSSVDVRLRRQIKALEE 72
 
Name Accession Description Interval E-value
Med11 pfam10280
Mediator complex protein; Mediator is a large, modular protein complex that is conserved from ...
 8-72 1.96e-12

Mediator complex protein; Mediator is a large, modular protein complex that is conserved from yeast to human and conveys regulatory signals from DNA-binding transcription factors to RNA polymerase II. Not only are the polypeptides conserved but the structural organization is also largely conserved. One or two subunits are either fungal or vertebral specific but Med11 is one of the subunits that is conserved from fungi to humans. Med11 appears to be necessary for the full and successful assembly of the core head sub-region.


Pssm-ID: 463042  Cd Length: 119  Bit Score: 57.64  E-value: 1.96e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 756761766    8 NERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTA-------SVQHVEAELSAQIRYLTQ 72
Cdd:pfam10280   1 AERIQQLNEIDKDIVSLLQSASTAIQALSNSPSPSESLEARKEAFKAatsqfysTLSSVDVRLRRQIKALEE 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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