|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
16-754 |
0e+00 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 756.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 16 HWDQP-KNATPPPQLTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRDYFGYDVEFIMN 94
Cdd:PTZ00399 26 EWKKPsKEGKYLTGLKVNNSLTGGKVEFVPQNGRQVRWYTCGPTVYDSSHLGHARTYVTFDIIRRILEDYFGYDVFYVMN 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 95 ITDVDDKIIKRARQSHLlksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamka 174
Cdd:PTZ00399 106 ITDIDDKIIKRAREEKL--------------------------------------------------------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 175 qdsiateeakgrllnesrdvlsewldhnhgkdvrdhSVFDDLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVK 254
Cdd:PTZ00399 123 ------------------------------------SIFLELARKWEKEFFEDMKALNVRPPDVITRVSEYVPEIVDFIQ 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 255 KIISNGYAYAAEdGSVYFDTKAFEQNpKHFYAKLVPEAYGEDSEqllknMKESEGELSMSDdrlKSKRSPNDFALWKSSK 334
Cdd:PTZ00399 167 KIIDNGFAYESN-GSVYFDVEAFRKA-GHVYPKLEPESVADEDR-----IAEGEGALGKVS---GEKRSPNDFALWKASK 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 335 DGEPFWPSEWGNGRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPHWVNYFLHCGTLRIQGMKM 414
Cdd:PTZ00399 237 PGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNELAQSEAYFDKHQWVNYFLHSGHLHIKGLKM 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 415 SKSLKNFITIRKALEDYTPRQLRLLFLMHNWADVLDYSSSTMERALQFEKITNEFFLLVKDFLRRHYKpdrsEGYQKFQG 494
Cdd:PTZ00399 317 SKSLKNFITIRQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRESEL----TSPQKWTQ 392
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 495 KELKLMEEFGKLKSEVHEALCDSVDTRSVIEKFRELISLGNAYIVEKEKeghvPNCLLLRNIAAYITNLLKIFGAIPQSn 574
Cdd:PTZ00399 393 HDFELNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGEQ----PSAPLLRSVAQYVTKILSIFGLVEGS- 467
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 575 qeigfvsedecNGEGASTSFNKEAVVMPYLDALAQFREKVRLIAKEHKVN--------GILEECDTLRDKTLTELGVRLE 646
Cdd:PTZ00399 468 -----------DGLGSQGQNSTSENFKPLLEALLRFRDEVRDAAKAEMKLisldkkkkQLLQLCDKLRDEWLPNLGIRIE 536
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 647 DR-NGQTVVKLVDRATLLREQEQKDTEKKRKDKEKADKEQKAREKADKEAAAKKIKPEELFKQGEhvGKYSKFDERGVPT 725
Cdd:PTZ00399 537 DKpDGPSVWKLDDKEELQREKEEKEALKEQKRLRKLKKQEEKKKKELEKLEKAKIPPAEFFKRQE--DKYSAFDETGLPT 614
|
730 740
....*....|....*....|....*....
gi 808354779 726 HLADGTEITKSQIKKLEKVYEAQKKKYQQ 754
Cdd:PTZ00399 615 HDADGEEISKKERKKLSKEYDKQAKLHEE 643
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
29-647 |
7.56e-144 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 429.91 E-value: 7.56e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 29 LTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVDDKIIKRARq 108
Cdd:COG0215 2 LKLYNTLTRKKEEFVPLEPGKVRMYVCGPTVYDYAHIGHARTFVVFDVLRRYLR-YLGYKVTYVRNITDVDDKIIKRAA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 109 shllksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiatEEakgrll 188
Cdd:COG0215 80 ------------------------------------------------------------------------EE------ 81
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 189 nesrdvlsewldhnhGKDVRDhsvfddLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAeDG 268
Cdd:COG0215 82 ---------------GESIWE------LAERYIAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAYEA-DG 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 269 SVYFDTKAFEqnpkhfyaklvpeAYGEDSEQLLKNMkESEGELSMSDDrlksKRSPNDFALWKSSKDGEPFWPSEWGNGR 348
Cdd:COG0215 140 DVYFDVRSFP-------------DYGKLSGRNLDDL-RAGARVEVDEE----KRDPLDFALWKAAKPGEPSWDSPWGRGR 201
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 349 PGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKAL 428
Cdd:COG0215 202 PGWHIECSAMSTKYLGETFDIHGGGIDLIFPHHENEIAQSEAATGKP-FARYWMHNGFLTVNGEKMSKSLGNFFTVRDLL 280
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 429 EDYTPRQLRLLFLMHNWADVLDYSSSTMERALQ-FEKITNeffllvkdFLRRHykpdrsegyQKFQGKELKLMEEFGKLK 507
Cdd:COG0215 281 KKYDPEVLRFFLLSAHYRSPLDFSEEALEEAEKaLERLYN--------ALRRL---------EEALGAADSSAEEIEELR 343
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 508 SEVHEALCDSVDTRSVIEKFRELISLGNAYIVEKEKEghvpncLLLRNIAAYITNLLKIFGAIPQSNQEIGFVSEDEcng 587
Cdd:COG0215 344 EEFIAAMDDDFNTPEALAVLFELVREINKALDEGEDK------AALAALAALLRALGGVLGLLLLEPEAWQGAAEDE--- 414
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 588 egastsfnkeavvmpYLDALAQFREKVRLIAKEHKvNgiLEECDTLRDKtLTELGVRLED 647
Cdd:COG0215 415 ---------------LLDALIEALIEERAEARKAK-D--FARADRIRDE-LAALGIVLED 455
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
42-459 |
5.06e-124 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 372.86 E-value: 5.06e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 42 FVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVDDKIIKRARQshllksyfnesqa 121
Cdd:pfam01406 2 FVPLHQGKVTMYVCGPTVYDYSHIGHARSAVAFDVLRRYLQ-ALGYDVQFVQNFTDIDDKIIKRARQ------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 122 ppvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeakgrlLNESrdvlsewldh 201
Cdd:pfam01406 68 ------------------------------------------------------------------EGES---------- 71
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 202 nhgkdvrdhsvFDDLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAEDGSVYFDTKAFeqnp 281
Cdd:pfam01406 72 -----------FRQLAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYVSDNGDVYFDVSSF---- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 282 kHFYAKLVPEaygeDSEQLlknmkesegELSMSDDRLKSKRSPNDFALWKSSKDGEPFWPSEWGNGRPGWHIECSVMSSA 361
Cdd:pfam01406 137 -PDYGKLSGQ----NLEQL---------EAGARGEVSEGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARK 202
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 362 ICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKALEDYTPRQLRLLFL 441
Cdd:pfam01406 203 YLGDQIDIHGGGIDLAFPHHENEIAQSEAAFDKQ-LANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLL 281
|
410
....*....|....*...
gi 808354779 442 MHNWADVLDYSSSTMERA 459
Cdd:pfam01406 282 SVHYRSPLDFSEELLEQA 299
|
|
| cysS |
TIGR00435 |
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ... |
29-655 |
1.65e-122 |
|
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273076 [Multi-domain] Cd Length: 464 Bit Score: 374.80 E-value: 1.65e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 29 LTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVDDKIIKRARQ 108
Cdd:TIGR00435 1 LKLYNTLTRQKEEFEPLVQGKVKMYVCGPTVYDYCHIGHARTAIVFDVLRRYLR-YLGYKVQYVQNITDIDDKIIKRARE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 109 shllksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeakgrlL 188
Cdd:TIGR00435 80 -------------------------------------------------------------------------------N 80
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 189 NESRDVLSEwldhnhgkdvrdhsvfddlakTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAEDG 268
Cdd:TIGR00435 81 GESVYEVSE---------------------RFIEAYFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSDNG 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 269 SVYFDTKAFEQnpkhfyaklvpeaYGEDSEQLLKNMKESEGelsmsDDRLKSKRSPNDFALWKSSKDGEPFWPSEWGNGR 348
Cdd:TIGR00435 140 DVYFDVSKFKD-------------YGKLSKQDLDQLEAGAR-----VDVDEAKRNKLDFVLWKSSKEGEPKWDSPWGKGR 201
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 349 PGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKAL 428
Cdd:TIGR00435 202 PGWHIECSAMNDKYLGDQIDIHGGGVDLIFPHHENEIAQSEAAFGKQ-LAKYWMHNGFLMIDNEKMSKSLGNFFTVRDVL 280
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 429 EDYTPRQLRLLFLMHNWADVLDYSSSTMERA-LQFEKITNEFFLLVKDFlrrhykpdrseGYQKFQGKELKLMEEfgKLK 507
Cdd:TIGR00435 281 KNYDPEILRYFLLSVHYRSPLDFSEELLEAAkNALERLYKALRVLDTSL-----------AYSGNQSLNKFPDEK--EFE 347
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 508 SEVHEALCDSVDTRSVIEKFRELISLGNAYIVEKEKEGHVPNCllLRNIAAYITNLLKIfgaipqsnqEIGFVSEDECNG 587
Cdd:TIGR00435 348 ARFVEAMDDDLNTANALAVLFELAKSINLTFVSKADAALLIEH--LIFLESRLGLLLGL---------PSKPVQAGSNDD 416
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 808354779 588 EGAStsfnkEAVVMPyldalaqfrekvRLIAKEHKVngiLEECDTLRDKtLTELGVRLEDRNGQTVVK 655
Cdd:TIGR00435 417 LGEI-----EALIEE------------RSIARKEKD---FAKADEIRDE-LAKKGIVLEDTPQGTTWR 463
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
30-452 |
1.85e-96 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 297.95 E-value: 1.85e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 30 TVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRDYfGYDVEFIMNITDVDDKIIKRARQS 109
Cdd:cd00672 1 RLYNTLTRQKEEFVPLNPGLVTMYVCGPTVYDYAHIGHARTYVVFDVLRRYLEDL-GYKVRYVQNITDIDDKIIKRAREE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 110 HLLksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeakgrlln 189
Cdd:cd00672 80 GLS----------------------------------------------------------------------------- 82
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 190 esrdvlsewldhnhgkdvrdhsvFDDLAKTYEKEFLADMARLNVLPVDVLTRVseyvpevityvkkiisngyayaaedgs 269
Cdd:cd00672 83 -----------------------WKEVADYYTKEFFEDMKALNVLPPDVVPRV--------------------------- 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 270 vyfdtkafeqnpkhfyaklvpeaygedseqllknmkesegelsmsddrlkskrspndfalwksskdgepfwpsewgngrp 349
Cdd:cd00672 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 350 gWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKALE 429
Cdd:cd00672 113 -WHIECSAMAMKYLGETFDIHGGGVDLIFPHHENEIAQSEAATGKP-FARYWLHTGHLTIDGEKMSKSLGNFITVRDALK 190
|
410 420
....*....|....*....|...
gi 808354779 430 DYTPRQLRLLFLMHNWADVLDYS 452
Cdd:cd00672 191 KYDPEVLRLALLSSHYRSPLDFS 213
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
16-754 |
0e+00 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 756.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 16 HWDQP-KNATPPPQLTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRDYFGYDVEFIMN 94
Cdd:PTZ00399 26 EWKKPsKEGKYLTGLKVNNSLTGGKVEFVPQNGRQVRWYTCGPTVYDSSHLGHARTYVTFDIIRRILEDYFGYDVFYVMN 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 95 ITDVDDKIIKRARQSHLlksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamka 174
Cdd:PTZ00399 106 ITDIDDKIIKRAREEKL--------------------------------------------------------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 175 qdsiateeakgrllnesrdvlsewldhnhgkdvrdhSVFDDLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVK 254
Cdd:PTZ00399 123 ------------------------------------SIFLELARKWEKEFFEDMKALNVRPPDVITRVSEYVPEIVDFIQ 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 255 KIISNGYAYAAEdGSVYFDTKAFEQNpKHFYAKLVPEAYGEDSEqllknMKESEGELSMSDdrlKSKRSPNDFALWKSSK 334
Cdd:PTZ00399 167 KIIDNGFAYESN-GSVYFDVEAFRKA-GHVYPKLEPESVADEDR-----IAEGEGALGKVS---GEKRSPNDFALWKASK 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 335 DGEPFWPSEWGNGRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPHWVNYFLHCGTLRIQGMKM 414
Cdd:PTZ00399 237 PGEPSWDSPWGKGRPGWHIECSAMASNILGDPIDIHSGGIDLKFPHHDNELAQSEAYFDKHQWVNYFLHSGHLHIKGLKM 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 415 SKSLKNFITIRKALEDYTPRQLRLLFLMHNWADVLDYSSSTMERALQFEKITNEFFLLVKDFLRRHYKpdrsEGYQKFQG 494
Cdd:PTZ00399 317 SKSLKNFITIRQALSKYTARQIRLLFLLHKWDKPMNYSDESMDEAIEKDKVFFNFFANVKIKLRESEL----TSPQKWTQ 392
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 495 KELKLMEEFGKLKSEVHEALCDSVDTRSVIEKFRELISLGNAYIVEKEKeghvPNCLLLRNIAAYITNLLKIFGAIPQSn 574
Cdd:PTZ00399 393 HDFELNELFEETKSAVHAALLDNFDTPEALQALQKLISATNTYLNSGEQ----PSAPLLRSVAQYVTKILSIFGLVEGS- 467
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 575 qeigfvsedecNGEGASTSFNKEAVVMPYLDALAQFREKVRLIAKEHKVN--------GILEECDTLRDKTLTELGVRLE 646
Cdd:PTZ00399 468 -----------DGLGSQGQNSTSENFKPLLEALLRFRDEVRDAAKAEMKLisldkkkkQLLQLCDKLRDEWLPNLGIRIE 536
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 647 DR-NGQTVVKLVDRATLLREQEQKDTEKKRKDKEKADKEQKAREKADKEAAAKKIKPEELFKQGEhvGKYSKFDERGVPT 725
Cdd:PTZ00399 537 DKpDGPSVWKLDDKEELQREKEEKEALKEQKRLRKLKKQEEKKKKELEKLEKAKIPPAEFFKRQE--DKYSAFDETGLPT 614
|
730 740
....*....|....*....|....*....
gi 808354779 726 HLADGTEITKSQIKKLEKVYEAQKKKYQQ 754
Cdd:PTZ00399 615 HDADGEEISKKERKKLSKEYDKQAKLHEE 643
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
29-647 |
7.56e-144 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 429.91 E-value: 7.56e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 29 LTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVDDKIIKRARq 108
Cdd:COG0215 2 LKLYNTLTRKKEEFVPLEPGKVRMYVCGPTVYDYAHIGHARTFVVFDVLRRYLR-YLGYKVTYVRNITDVDDKIIKRAA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 109 shllksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiatEEakgrll 188
Cdd:COG0215 80 ------------------------------------------------------------------------EE------ 81
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 189 nesrdvlsewldhnhGKDVRDhsvfddLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAeDG 268
Cdd:COG0215 82 ---------------GESIWE------LAERYIAAFHEDMDALGVLPPDIEPRATEHIPEMIELIERLIEKGHAYEA-DG 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 269 SVYFDTKAFEqnpkhfyaklvpeAYGEDSEQLLKNMkESEGELSMSDDrlksKRSPNDFALWKSSKDGEPFWPSEWGNGR 348
Cdd:COG0215 140 DVYFDVRSFP-------------DYGKLSGRNLDDL-RAGARVEVDEE----KRDPLDFALWKAAKPGEPSWDSPWGRGR 201
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 349 PGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKAL 428
Cdd:COG0215 202 PGWHIECSAMSTKYLGETFDIHGGGIDLIFPHHENEIAQSEAATGKP-FARYWMHNGFLTVNGEKMSKSLGNFFTVRDLL 280
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 429 EDYTPRQLRLLFLMHNWADVLDYSSSTMERALQ-FEKITNeffllvkdFLRRHykpdrsegyQKFQGKELKLMEEFGKLK 507
Cdd:COG0215 281 KKYDPEVLRFFLLSAHYRSPLDFSEEALEEAEKaLERLYN--------ALRRL---------EEALGAADSSAEEIEELR 343
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 508 SEVHEALCDSVDTRSVIEKFRELISLGNAYIVEKEKEghvpncLLLRNIAAYITNLLKIFGAIPQSNQEIGFVSEDEcng 587
Cdd:COG0215 344 EEFIAAMDDDFNTPEALAVLFELVREINKALDEGEDK------AALAALAALLRALGGVLGLLLLEPEAWQGAAEDE--- 414
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 588 egastsfnkeavvmpYLDALAQFREKVRLIAKEHKvNgiLEECDTLRDKtLTELGVRLED 647
Cdd:COG0215 415 ---------------LLDALIEALIEERAEARKAK-D--FARADRIRDE-LAALGIVLED 455
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
42-459 |
5.06e-124 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 372.86 E-value: 5.06e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 42 FVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVDDKIIKRARQshllksyfnesqa 121
Cdd:pfam01406 2 FVPLHQGKVTMYVCGPTVYDYSHIGHARSAVAFDVLRRYLQ-ALGYDVQFVQNFTDIDDKIIKRARQ------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 122 ppvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeakgrlLNESrdvlsewldh 201
Cdd:pfam01406 68 ------------------------------------------------------------------EGES---------- 71
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 202 nhgkdvrdhsvFDDLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAEDGSVYFDTKAFeqnp 281
Cdd:pfam01406 72 -----------FRQLAARFIEAYTKDMDALNVLPPDLEPRVTEHIDEIIEFIERLIKKGYAYVSDNGDVYFDVSSF---- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 282 kHFYAKLVPEaygeDSEQLlknmkesegELSMSDDRLKSKRSPNDFALWKSSKDGEPFWPSEWGNGRPGWHIECSVMSSA 361
Cdd:pfam01406 137 -PDYGKLSGQ----NLEQL---------EAGARGEVSEGKRDPLDFALWKASKEGEPSWDSPWGKGRPGWHIECSAMARK 202
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 362 ICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKALEDYTPRQLRLLFL 441
Cdd:pfam01406 203 YLGDQIDIHGGGIDLAFPHHENEIAQSEAAFDKQ-LANYWLHNGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEILRYFLL 281
|
410
....*....|....*...
gi 808354779 442 MHNWADVLDYSSSTMERA 459
Cdd:pfam01406 282 SVHYRSPLDFSEELLEQA 299
|
|
| cysS |
TIGR00435 |
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not ... |
29-655 |
1.65e-122 |
|
cysteinyl-tRNA synthetase; This model finds the cysteinyl-tRNA synthetase from most but not from all species. The enzyme from one archaeal species, Archaeoglobus fulgidus, is found but the equivalent enzymes from some other Archaea, including Methanococcus jannaschii, are not found, although biochemical evidence suggests that tRNA(Cys) in these species are charged directly with Cys rather than through a misacylation and correction pathway as for tRNA(Gln). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273076 [Multi-domain] Cd Length: 464 Bit Score: 374.80 E-value: 1.65e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 29 LTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVDDKIIKRARQ 108
Cdd:TIGR00435 1 LKLYNTLTRQKEEFEPLVQGKVKMYVCGPTVYDYCHIGHARTAIVFDVLRRYLR-YLGYKVQYVQNITDIDDKIIKRARE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 109 shllksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeakgrlL 188
Cdd:TIGR00435 80 -------------------------------------------------------------------------------N 80
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 189 NESRDVLSEwldhnhgkdvrdhsvfddlakTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAEDG 268
Cdd:TIGR00435 81 GESVYEVSE---------------------RFIEAYFEDMKALNVLPPDLEPRATEHIDEIIEFIEQLIEKGYAYVSDNG 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 269 SVYFDTKAFEQnpkhfyaklvpeaYGEDSEQLLKNMKESEGelsmsDDRLKSKRSPNDFALWKSSKDGEPFWPSEWGNGR 348
Cdd:TIGR00435 140 DVYFDVSKFKD-------------YGKLSKQDLDQLEAGAR-----VDVDEAKRNKLDFVLWKSSKEGEPKWDSPWGKGR 201
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 349 PGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKAL 428
Cdd:TIGR00435 202 PGWHIECSAMNDKYLGDQIDIHGGGVDLIFPHHENEIAQSEAAFGKQ-LAKYWMHNGFLMIDNEKMSKSLGNFFTVRDVL 280
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 429 EDYTPRQLRLLFLMHNWADVLDYSSSTMERA-LQFEKITNEFFLLVKDFlrrhykpdrseGYQKFQGKELKLMEEfgKLK 507
Cdd:TIGR00435 281 KNYDPEILRYFLLSVHYRSPLDFSEELLEAAkNALERLYKALRVLDTSL-----------AYSGNQSLNKFPDEK--EFE 347
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 508 SEVHEALCDSVDTRSVIEKFRELISLGNAYIVEKEKEGHVPNCllLRNIAAYITNLLKIfgaipqsnqEIGFVSEDECNG 587
Cdd:TIGR00435 348 ARFVEAMDDDLNTANALAVLFELAKSINLTFVSKADAALLIEH--LIFLESRLGLLLGL---------PSKPVQAGSNDD 416
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 808354779 588 EGAStsfnkEAVVMPyldalaqfrekvRLIAKEHKVngiLEECDTLRDKtLTELGVRLEDRNGQTVVK 655
Cdd:TIGR00435 417 LGEI-----EALIEE------------RSIARKEKD---FAKADEIRDE-LAKKGIVLEDTPQGTTWR 463
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
30-452 |
1.85e-96 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 297.95 E-value: 1.85e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 30 TVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRDYfGYDVEFIMNITDVDDKIIKRARQS 109
Cdd:cd00672 1 RLYNTLTRQKEEFVPLNPGLVTMYVCGPTVYDYAHIGHARTYVVFDVLRRYLEDL-GYKVRYVQNITDIDDKIIKRAREE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 110 HLLksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeakgrlln 189
Cdd:cd00672 80 GLS----------------------------------------------------------------------------- 82
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 190 esrdvlsewldhnhgkdvrdhsvFDDLAKTYEKEFLADMARLNVLPVDVLTRVseyvpevityvkkiisngyayaaedgs 269
Cdd:cd00672 83 -----------------------WKEVADYYTKEFFEDMKALNVLPPDVVPRV--------------------------- 112
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 270 vyfdtkafeqnpkhfyaklvpeaygedseqllknmkesegelsmsddrlkskrspndfalwksskdgepfwpsewgngrp 349
Cdd:cd00672 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 350 gWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIRKALE 429
Cdd:cd00672 113 -WHIECSAMAMKYLGETFDIHGGGVDLIFPHHENEIAQSEAATGKP-FARYWLHTGHLTIDGEKMSKSLGNFITVRDALK 190
|
410 420
....*....|....*....|...
gi 808354779 430 DYTPRQLRLLFLMHNWADVLDYS 452
Cdd:cd00672 191 KYDPEVLRLALLSSHYRSPLDFS 213
|
|
| PLN02946 |
PLN02946 |
cysteine-tRNA ligase |
23-459 |
2.53e-87 |
|
cysteine-tRNA ligase
Pssm-ID: 178532 [Multi-domain] Cd Length: 557 Bit Score: 286.06 E-value: 2.53e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 23 ATPPPQLTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVDDKI 102
Cdd:PLN02946 54 ASRGRELHLYNTMSRKKELFKPKVEGKVGMYVCGVTAYDLSHIGHARVYVTFDVLYRYLK-HLGYEVRYVRNFTDVDDKI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 103 IKRARQshllksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaLEEamkaqDSIAtee 182
Cdd:PLN02946 133 IARANE-----------------------------------------------------------LGE-----DPIS--- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 183 akgrllnesrdvlsewldhnhgkdvrdhsvfddLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYA 262
Cdd:PLN02946 146 ---------------------------------LSRRYCEEFLSDMAYLHCLPPSVEPRVSDHIPQIIDMIKQILDNGCA 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 263 YAAeDGSVYFDTKAFeqnpkhfyaklvPEaYGEDSEQLLKNMKEseGELSMSDDRlksKRSPNDFALWKSSKDGEPFWPS 342
Cdd:PLN02946 193 YRV-DGDVYFSVDKF------------PE-YGKLSGRKLEDNRA--GERVAVDSR---KKNPADFALWKAAKEGEPFWDS 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 343 EWGNGRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPHwVNYFLHCGTLRIQGMKMSKSLKNFI 422
Cdd:PLN02946 254 PWGPGRPGWHIECSAMSAAYLGHSFDIHGGGMDLVFPHHENEIAQSCAACCDSN-ISYWIHNGFVTVDSEKMSKSLGNFF 332
|
410 420 430
....*....|....*....|....*....|....*..
gi 808354779 423 TIRKALEDYTPRQLRLLFLMHNWADVLDYSSSTMERA 459
Cdd:PLN02946 333 TIRQVIDLYHPLALRLFLLGTHYRSPINYSDVQLESA 369
|
|
| cysS |
PRK14535 |
cysteinyl-tRNA synthetase; Provisional |
2-459 |
2.77e-63 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173001 [Multi-domain] Cd Length: 699 Bit Score: 224.60 E-value: 2.77e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 2 DPNLR----PVAVKRVQKHWDQPKNATPPPQLTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDIL 77
Cdd:PRK14535 197 NPQLRnvpwSVSTGTEQKLSSEQQRLIHNPMTTIYNTLTRQKEPFAPIDPENVRMYVCGMTVYDYCHLGHARVMVVFDMI 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 78 RRVFRDyFGYDVEFIMNITDVDDKIIKRARQSHllksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevm 157
Cdd:PRK14535 277 ARWLRE-CGYPLTYVRNITDIDDKIIARAAENG----------------------------------------------- 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 158 ikkvqqqssaleeamkaqdsiateEAKGRLLNESRDVLSEwldhnhgkdvrdhsvfddlaktyekeflaDMARLNVLPVD 237
Cdd:PRK14535 309 ------------------------ETIGELTARFIQAMHE-----------------------------DADALGVLRPD 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 238 VLTRVSEYVPEVITYVKKIISNGYAYAAEDGSVYFDTKAFEqnpkhfyaklvpeAYGEDSEQLLKNMKEseGELSMSDDr 317
Cdd:PRK14535 336 IEPKATENIPQMIAMIETLIQNGKAYPAANGDVYYAVREFA-------------AYGQLSGKSLDDLRA--GERVEVDG- 399
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 318 lkSKRSPNDFALWKSSKDGEPFWPSEWGNGRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEA------- 390
Cdd:PRK14535 400 --FKRDPLDFVLWKAAKAGEPAWESPWGNGRPGWHIECSAMSENLFGDTFDIHGGGADLQFPHHENEIAQSVGatghtcg 477
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 808354779 391 -HYDDPH-------WVNYFLHCGTLRIQGMKMSKSLKNFITIRKALEDYTPRQLRLLFLMHNWADVLDYSSSTMERA 459
Cdd:PRK14535 478 hHHAQTHhgqsiasHVKYWLHNGFIRVDGEKMSKSLGNFFTIREVLKQYDPEVVRFFILRAHYRSPLNYSDAHLDDA 554
|
|
| cysS |
PRK14536 |
cysteinyl-tRNA synthetase; Provisional |
29-459 |
6.58e-59 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 184731 [Multi-domain] Cd Length: 490 Bit Score: 207.47 E-value: 6.58e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 29 LTVYNSLTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDVddkiikrarq 108
Cdd:PRK14536 3 LRLYNTLGRQQEEFQPIEHGHVRLYGCGPTVYNYAHIGNLRTYVFQDTLRRTLH-FLGYRVTHVMNITDV---------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 109 SHLlksyfnesqappvmkvcedvvaalehfktkfETEMDPDKKKMfevmikkvqqqssaleeamkaqdsIATEEAKGrll 188
Cdd:PRK14536 72 GHL-------------------------------TDDADSGEDKM------------------------VKSAQEHG--- 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 189 nesrdvlsewldhnhgkdvrdHSVFDdLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAYAAeDG 268
Cdd:PRK14536 94 ---------------------KSVLE-IAAHYTAAFFRDTARLNIERPSIVCNATEHIQDMIALIKRLEARGHTYCA-GG 150
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 269 SVYFDTKAFeqnPKhfyaklvpeaYGEDSEQLLKNMKEseGELSMSDdrlKSKRSPNDFALWKSSKDGEP---FWPSEWG 345
Cdd:PRK14536 151 NVYFDIRTF---PS----------YGSLASAAVEDLQA--GARIEHD---TNKRNPHDFVLWFTRSKFENhalTWDSPWG 212
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 346 NGRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPhWVNYFLHCGTLRIQGMKMSKSLKNFITIR 425
Cdd:PRK14536 213 RGYPGWHIECSAMSMKYLGEQCDIHIGGVDHIRVHHTNEIAQCEAATGKP-WVRYWLHHEFLLMNKGKMSKSAGQFLTLS 291
|
410 420 430
....*....|....*....|....*....|....*
gi 808354779 426 KALED-YTPRQLRLLFLMHNWADVLDYSSSTMERA 459
Cdd:PRK14536 292 SLQEKgFQPLDYRFFLLGGHYRSQLAFSWEALKTA 326
|
|
| mycothiol_MshC |
TIGR03447 |
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this ... |
26-461 |
1.26e-56 |
|
cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Members of this protein family are MshC, l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, an enzyme that uses ATP to ligate a Cys residue to a mycothiol precursor molecule, in the second to last step in mycothiol biosynthesis. This enzyme shows considerable homology to Cys--tRNA ligases, and many instances are misannotated as such. Mycothiol is found in Mycobacterium tuberculosis, Corynebacterium glutamicum, Streptomyces coelicolor, and various other members of the Actinobacteria. Mycothiol is an analog to glutathione. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]
Pssm-ID: 132488 [Multi-domain] Cd Length: 411 Bit Score: 199.18 E-value: 1.26e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 26 PPQLTVYNSLTRQ-KEVFVPNEgkrVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRDYfGYDVEFIMNITDVDDKIIK 104
Cdd:TIGR03447 15 GPPLRLFDTADGQvRPVEPGPE---AGMYVCGITPYDATHLGHAATYLTFDLVNRVWRDA-GHRVHYVQNVTDVDDPLFE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 105 RArqshllksyfnesqappvmkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeak 184
Cdd:TIGR03447 91 RA------------------------------------------------------------------------------ 92
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 185 grllneSRDvlsewldhnhGKDVRDhsvfddLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAY- 263
Cdd:TIGR03447 93 ------ERD----------GVDWRE------LGTSQIDLFREDMEALRVLPPRDYIGAVESIDEVVEMVEKLLASGAAYi 150
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 264 --AAEDGSVYFDTKAFEQnpkhfyaklvpeaYGEDSEQLLKNMKESEGELSMSDDRlKSKRSPNDFALWKSSKDGEPFWP 341
Cdd:TIGR03447 151 veGPEYPDVYFSIDATEQ-------------FGYESGYDRATMLELFAERGGDPDR-PGKRDPLDALLWRAAREGEPSWD 216
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 342 SEWGNGRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPHWVNYFLHCGTLRIQGMKMSKSLKNF 421
Cdd:TIGR03447 217 SPFGRGRPGWHIECSAIALNRLGAGFDIQGGGSDLIFPHHEFSAAHAEAATGVRRMARHYVHAGMIGLDGEKMSKSLGNL 296
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 808354779 422 I---TIRKALEDytPRQLRLLFLMHNWADVLDYSSSTMERALQ 461
Cdd:TIGR03447 297 VfvsKLRAAGVD--PAAIRLGLLAGHYRQDRDWTDAVLAEAEA 337
|
|
| PRK12418 |
PRK12418 |
cysteinyl-tRNA synthetase; Provisional |
45-461 |
6.98e-53 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 183518 [Multi-domain] Cd Length: 384 Bit Score: 187.83 E-value: 6.98e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 45 NEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRDYfGYDVEFIMNITDVDDKIIKRARqshllksyfnesqappv 124
Cdd:PRK12418 5 APGGTATMYVCGITPYDATHLGHAATYLAFDLVNRVWRDA-GHDVHYVQNVTDVDDPLLERAA----------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 125 mkvcedvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsiateeakgrllnesRDvlsewldhnhG 204
Cdd:PRK12418 67 -------------------------------------------------------------------RD----------G 69
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 205 KDVRDhsvfddLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIISNGYAY---AAEDGSVYFDTKAfeqnp 281
Cdd:PRK12418 70 VDWRD------LAEREIALFREDMEALRVLPPRDYVGAVESIPEVVELVEKLLASGAAYvvdDEEYPDVYFSVDA----- 138
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 282 khfyaklvPEAYGEDS----EQLLKNMKESEGelsmsDDRLKSKRSPNDFALWKSSKDGEPFWPSEWGNGRPGWHIECSV 357
Cdd:PRK12418 139 --------TPQFGYESgydrATMLELFAERGG-----DPDRPGKRDPLDALLWRAARPGEPSWPSPFGPGRPGWHIECSA 205
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 358 MSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAHYDDPHWVNYFLHCGTLRIQGMKMSKSLKNFI---TIRKALEDytPR 434
Cdd:PRK12418 206 IALNRLGSGFDIQGGGSDLIFPHHEFSAAHAEAATGERRFARHYVHAGMIGLDGEKMSKSRGNLVfvsRLRAAGVD--PA 283
|
410 420
....*....|....*....|....*..
gi 808354779 435 QLRLLFLMHNWADVLDYSSSTMERALQ 461
Cdd:PRK12418 284 AIRLALLAGHYRADREWTDAVLAEAEA 310
|
|
| cysS |
PRK14534 |
cysteinyl-tRNA synthetase; Provisional |
29-468 |
1.13e-35 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173000 [Multi-domain] Cd Length: 481 Bit Score: 141.53 E-value: 1.13e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 29 LTVYNslTRQKEVFVPNEGKRVRWYICGPTVYDSSHMGHARSYLSLDILRRVFRdYFGYDVEFIMNITDV---------- 98
Cdd:PRK14534 3 LKLYN--TKTKDLSELKNFSDVKVYACGPTVYNYAHIGNFRTYIFEDLLIKSLR-LLKYNVNYAMNITDIghltgdfddg 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 99 DDKIIKRARQSHLlksyfnesqappvmKVCEdvvaalehfktkfetemdpdkkkmfevmikkvqqqssaleeamkaqdsi 178
Cdd:PRK14534 80 EDKVVKAARERGL--------------TVYE------------------------------------------------- 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 179 ateeakgrllnesrdvlsewldhnhgkdvrdhsvfddLAKTYEKEFLADMARLNVLPVDVLTRVSEYVPEVITYVKKIIS 258
Cdd:PRK14534 97 -------------------------------------ISRFFTEAFFDDCKKLNIVYPDKVLVASEYIPIMIEVVKVLEE 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 259 NGYAYAAeDGSVYFDTKAFEqnpkhfyaklvpeAYGEDSEQLLKNMKEsegelsMSDDRL---KSKRSPNDFALWKSS-- 333
Cdd:PRK14534 140 NGFTYFV-NGNVYFDTSCFK-------------SYGQMAGINLNDFKD------MSVSRVeidKSKRNKSDFVLWFTNsk 199
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 334 -KDGEPFWPSEWGNGRPGWHIECSVMSSAICGSKLDIHAGGFDLKFPHHDNEIAQVEAhYDDPHWVNYFLHCGTLRIQGM 412
Cdd:PRK14534 200 fKDQEMKWDSPWGFGYPSWHLECAAMNLEYFKSTLDIHLGGVDHIGVHHINEIAIAEC-YLNKKWCDMFVHGEFLIMEYE 278
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 808354779 413 KMSKSLKNFITIrKALED--YTPRQLRLLFLMHNWADVLDYSSSTmeraLQFEKITNE 468
Cdd:PRK14534 279 KMSKSNNNFITI-KDLEDqgFSPLDFRYFCLTAHYRTQLKFTFNN----LKACKIARE 331
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
405-581 |
2.15e-07 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 54.49 E-value: 2.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 405 GTLRIQGMKMSKSLKNFITIRKALEDYTPRQLRlLFLMHN---WADvLDYSSSTMERAL-QFEKITNefflLVKDFLRrh 480
Cdd:PRK12300 569 GFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVR-LYLTSSaelLQD-ADWREKEVESVRrQLERFYE----LAKELIE-- 640
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808354779 481 YKPDRSEGYQkfqgkELKLMEEFGKLKSEVHEALcDSVDTRS-VIEKFRELISLGNAYIvekeKEGHVPNCLLLRNIAAY 559
Cdd:PRK12300 641 IGGEEELRFI-----DKWLLSRLNRIIKETTEAM-ESFQTRDaVQEAFYELLNDLRWYL----RRVGEANNKVLREVLEI 710
|
170 180
....*....|....*....|....*....
gi 808354779 560 ITNLLKIFgaIPQSNQEI-------GFVS 581
Cdd:PRK12300 711 WIRLLAPF--TPHLAEELwhklggeGFVS 737
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
53-106 |
1.48e-06 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 48.24 E-value: 1.48e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 808354779 53 YICGPTVYDSSHMGHARSYLSLDILRRVFRDyFGYDVEFIMNITDVDDKIIKRA 106
Cdd:cd00802 2 TFSGITPNGYLHIGHLRTIVTFDFLAQAYRK-LGYKVRCIALIDDAGGLIGDPA 54
|
|
| |
