UBA domain-containing protein [Caenorhabditis elegans]
Protein Classification
UBA domain-containing protein( domain architecture ID 229521)
ubiquitin-associated (UBA) domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| UBA_like_SF super family | cl21463 | UBA domain-like superfamily; The ubiquitin-associated (UBA) domain-like superfamily contains ... |
43-72 | 4.28e-04 | ||
UBA domain-like superfamily; The ubiquitin-associated (UBA) domain-like superfamily contains alpha-helical structural homology ubiquitin-binding domains, including UBA domains and coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domains which share a common three-helical bundle architecture. UBA domains are commonly occurring sequence motifs found in proteins involved in ubiquitin-mediated proteolysis. They contribute to ubiquitin (Ub) binding or ubiquitin-like (UbL) domain binding. However, some kinds of UBA domains can only bind the UbL domain, but not the Ub domain. UBA domains are normally comprised of compact three-helix bundles which contain a conserved GF/Y-loop. They can bind polyubiquitin with high affinity. They also bind monoubiquitin and other proteins. Most UBA domain-containing proteins have one UBA domain, but some harbor two or three UBA domains. CUE domain containing proteins are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. This superfamily also includes many UBA-like domains found in AMP-activated protein kinase (AMPK) related kinases, the NXF family of mRNA nuclear export factors, elongation factor Ts (EF-Ts), nascent polypeptide-associated complex subunit alpha (NACA) and similar proteins. Although many UBA-like domains may have a conserved TG but not GF/Y-loop, they still show a high level of structural and sequence similarity with three-helical ubiquitin binding domains. The actual alignment was detected with superfamily member cd14312: Pssm-ID: 473871 Cd Length: 36 Bit Score: 34.24 E-value: 4.28e-04
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| Name | Accession | Description | Interval | E-value | ||
| UBA_II_E2_UBC27_like | cd14312 | UBA domain found in plant ubiquitin-conjugating enzyme E2 27 and similar proteins; UBC27, also ... |
43-72 | 4.28e-04 | ||
UBA domain found in plant ubiquitin-conjugating enzyme E2 27 and similar proteins; UBC27, also called ubiquitin carrier protein 27, functions as a class II ubiquitin-conjugating (UBC) enzyme (E2). E2, together with E1 (ubiquitin-activating enzyme UBA) and E3 (ubiquitin ligase), is required in the multi-step reaction of ubiquitin conjugation. Unlike other Arabidopsis UBCs, in addition to an N-terminal ubiquitin-conjugating enzyme E2 catalytic domain (UBCc), UBC27 has an additional C-terminal ubiquitin-associated domain (UBA). Pssm-ID: 270497 Cd Length: 36 Bit Score: 34.24 E-value: 4.28e-04
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| Name | Accession | Description | Interval | E-value | ||
| UBA_II_E2_UBC27_like | cd14312 | UBA domain found in plant ubiquitin-conjugating enzyme E2 27 and similar proteins; UBC27, also ... |
43-72 | 4.28e-04 | ||
UBA domain found in plant ubiquitin-conjugating enzyme E2 27 and similar proteins; UBC27, also called ubiquitin carrier protein 27, functions as a class II ubiquitin-conjugating (UBC) enzyme (E2). E2, together with E1 (ubiquitin-activating enzyme UBA) and E3 (ubiquitin ligase), is required in the multi-step reaction of ubiquitin conjugation. Unlike other Arabidopsis UBCs, in addition to an N-terminal ubiquitin-conjugating enzyme E2 catalytic domain (UBCc), UBC27 has an additional C-terminal ubiquitin-associated domain (UBA). Pssm-ID: 270497 Cd Length: 36 Bit Score: 34.24 E-value: 4.28e-04
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| UBA_II_E2_pyUCE_like | cd14314 | UBA domain found in a putative ubiquitin conjugating enzyme from plasmodium Yoelii (pyUCE) and ... |
36-72 | 9.34e-04 | ||
UBA domain found in a putative ubiquitin conjugating enzyme from plasmodium Yoelii (pyUCE) and similar proteins; P. Yoelii ubiquitin-conjugating enzyme and other uncharacterized family members show high sequence similarity to the human Huntingtin interacting protein-2 (HIP2) which belongs to a class II E2 ubiquitin-conjugating enzyme family. These proteins may play roles in the ubiquitin-mediated protein degradation pathway. They all contain a C-terminal ubiquitin-associated (UBA) domain in addition to an N-terminal catalytic ubiquitin-conjugating enzyme E2 (UBCc) domain. Pssm-ID: 270499 Cd Length: 37 Bit Score: 33.06 E-value: 9.34e-04
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