NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|815890979|ref|NP_001295112|]
View 

CDK5 regulatory subunit-associated protein 3 isoform 2 [Mus musculus]

Protein Classification

CDK5RAP3 family protein( domain architecture ID 10528880)

CDK5 regulatory subunit-associated protein 3 (CDK5RAP3) family protein is a DUF773 domain-containing protein similar to vertebrate CDK5RAP3 that acts as a tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CDK5RAP3 pfam05600
CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic ...
 2-389 4.51e-174

CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic sequences such as CDK5RAP3 (also known as C53 or LZAP) which serves as a probable tumour suppressor. Initially identified as a CDK5R1 interactor controlling cell proliferation. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. It has been shown to bind Wip1 and stimulates its phosphatase activity.


:

Pssm-ID: 461688  Cd Length: 506  Bit Score: 494.89  E-value: 4.51e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979    2 ELCSLLVRNVSYEIPSLKKQIAKCQQLQQEYSRKEEEGQAGAAEMREQFYHSCKQYGITGDNVRRELLALVKDLPSQLAE 81
Cdd:pfam05600 110 EAAQILVRNVNYEIPGLKKQIAKLQQQLEELERKEADLKRSAALARAKYEEACKQLGIKGKNVREELLELVKDLPSLFEK 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979   82 IGAGAQSLGEAIDLYQACVEFVCDSPTE--QVLPMLRYVQKKGNSTVYEWRTGTEPSVVERPQLEEPPEQVQE-----DE 154
Cdd:pfam05600 190 IAESLKDLSKAIEYYSAFVSFVHTESKKnsEVLPLLKFLIEKGNTTVYEWRTGEPPSKIEEPEVEVLTELQEAeeddgKE 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979  155 IDWGDFGVEAVSDSGIvaetpgiDWGISLESEAKDAGAD--KIDWGDDAAAASEITVLETGTE------APEGVARGSDA 226
Cdd:pfam05600 270 IDWGDDADGEVDAAEI-------DWGLGAVADDDVAEDEggEIDWGDSDMADIDISVEESGIDveedvsVAGGVARGDDA 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979  227 LTLLEYPETRNQFIDELMELEIFLSQRAVEMSEEA-DILSVSQFQLAPAILQGQTKEKMLSLVSTLQQLIGRLTSLRMQH 305
Cdd:pfam05600 343 LSLLDDTEYRNQFIDDLLELEAFLKQRLVELSNEStDVLSHQQFQSAPDVLQSQTPEEIEQMLSAVESALSLLTNPKTQH 422

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979  306 LFMILASPRYVDRVTEFLQQKLKQSQLLALKKELMVEKQQEALQEQAALEPKLDLLLEKTRELQKLIEADISKRYSGRPV 385
Cdd:pfam05600 423 LFLIKTSPRYVDRLVASLEQKLKQEEKLKESLKDLEEKREEARNQLSELEPKLELLIEKTRELQKLIEKDLSKRYKGRPV 502


                  ....
gi 815890979  386 NLMG 389
Cdd:pfam05600 503 NLMG 506
 
Name Accession Description Interval E-value
CDK5RAP3 pfam05600
CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic ...
 2-389 4.51e-174

CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic sequences such as CDK5RAP3 (also known as C53 or LZAP) which serves as a probable tumour suppressor. Initially identified as a CDK5R1 interactor controlling cell proliferation. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. It has been shown to bind Wip1 and stimulates its phosphatase activity.


Pssm-ID: 461688  Cd Length: 506  Bit Score: 494.89  E-value: 4.51e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979    2 ELCSLLVRNVSYEIPSLKKQIAKCQQLQQEYSRKEEEGQAGAAEMREQFYHSCKQYGITGDNVRRELLALVKDLPSQLAE 81
Cdd:pfam05600 110 EAAQILVRNVNYEIPGLKKQIAKLQQQLEELERKEADLKRSAALARAKYEEACKQLGIKGKNVREELLELVKDLPSLFEK 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979   82 IGAGAQSLGEAIDLYQACVEFVCDSPTE--QVLPMLRYVQKKGNSTVYEWRTGTEPSVVERPQLEEPPEQVQE-----DE 154
Cdd:pfam05600 190 IAESLKDLSKAIEYYSAFVSFVHTESKKnsEVLPLLKFLIEKGNTTVYEWRTGEPPSKIEEPEVEVLTELQEAeeddgKE 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979  155 IDWGDFGVEAVSDSGIvaetpgiDWGISLESEAKDAGAD--KIDWGDDAAAASEITVLETGTE------APEGVARGSDA 226
Cdd:pfam05600 270 IDWGDDADGEVDAAEI-------DWGLGAVADDDVAEDEggEIDWGDSDMADIDISVEESGIDveedvsVAGGVARGDDA 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979  227 LTLLEYPETRNQFIDELMELEIFLSQRAVEMSEEA-DILSVSQFQLAPAILQGQTKEKMLSLVSTLQQLIGRLTSLRMQH 305
Cdd:pfam05600 343 LSLLDDTEYRNQFIDDLLELEAFLKQRLVELSNEStDVLSHQQFQSAPDVLQSQTPEEIEQMLSAVESALSLLTNPKTQH 422

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979  306 LFMILASPRYVDRVTEFLQQKLKQSQLLALKKELMVEKQQEALQEQAALEPKLDLLLEKTRELQKLIEADISKRYSGRPV 385
Cdd:pfam05600 423 LFLIKTSPRYVDRLVASLEQKLKQEEKLKESLKDLEEKREEARNQLSELEPKLELLIEKTRELQKLIEKDLSKRYKGRPV 502


                  ....
gi 815890979  386 NLMG 389
Cdd:pfam05600 503 NLMG 506
 
Name Accession Description Interval E-value
CDK5RAP3 pfam05600
CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic ...
 2-389 4.51e-174

CDK5 regulatory subunit-associated protein 3; This family contains several eukaryotic sequences such as CDK5RAP3 (also known as C53 or LZAP) which serves as a probable tumour suppressor. Initially identified as a CDK5R1 interactor controlling cell proliferation. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. It has been shown to bind Wip1 and stimulates its phosphatase activity.


Pssm-ID: 461688  Cd Length: 506  Bit Score: 494.89  E-value: 4.51e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979    2 ELCSLLVRNVSYEIPSLKKQIAKCQQLQQEYSRKEEEGQAGAAEMREQFYHSCKQYGITGDNVRRELLALVKDLPSQLAE 81
Cdd:pfam05600 110 EAAQILVRNVNYEIPGLKKQIAKLQQQLEELERKEADLKRSAALARAKYEEACKQLGIKGKNVREELLELVKDLPSLFEK 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979   82 IGAGAQSLGEAIDLYQACVEFVCDSPTE--QVLPMLRYVQKKGNSTVYEWRTGTEPSVVERPQLEEPPEQVQE-----DE 154
Cdd:pfam05600 190 IAESLKDLSKAIEYYSAFVSFVHTESKKnsEVLPLLKFLIEKGNTTVYEWRTGEPPSKIEEPEVEVLTELQEAeeddgKE 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979  155 IDWGDFGVEAVSDSGIvaetpgiDWGISLESEAKDAGAD--KIDWGDDAAAASEITVLETGTE------APEGVARGSDA 226
Cdd:pfam05600 270 IDWGDDADGEVDAAEI-------DWGLGAVADDDVAEDEggEIDWGDSDMADIDISVEESGIDveedvsVAGGVARGDDA 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979  227 LTLLEYPETRNQFIDELMELEIFLSQRAVEMSEEA-DILSVSQFQLAPAILQGQTKEKMLSLVSTLQQLIGRLTSLRMQH 305
Cdd:pfam05600 343 LSLLDDTEYRNQFIDDLLELEAFLKQRLVELSNEStDVLSHQQFQSAPDVLQSQTPEEIEQMLSAVESALSLLTNPKTQH 422

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890979  306 LFMILASPRYVDRVTEFLQQKLKQSQLLALKKELMVEKQQEALQEQAALEPKLDLLLEKTRELQKLIEADISKRYSGRPV 385
Cdd:pfam05600 423 LFLIKTSPRYVDRLVASLEQKLKQEEKLKESLKDLEEKREEARNQLSELEPKLELLIEKTRELQKLIEKDLSKRYKGRPV 502


                  ....
gi 815890979  386 NLMG 389
Cdd:pfam05600 503 NLMG 506
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH