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Conserved domains on  [gi|966751420|ref|NP_001304955|]
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serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 3 [Homo sapiens]

Protein Classification

serine/threonine-protein phosphatase 4 regulatory subunit 2( domain architecture ID 10557809)

serine/threonine-protein phosphatase 4 regulatory subunit 2 (PP4R2) is a regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process

Gene Ontology:  GO:0030289|GO:0019888

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP4R2 pfam09184
PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of ...
 1-221 1.23e-53

PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex. It has been shown to confer resistance to the anticancer drug cisplatin in yeast, and may confer resistance in higher eukaryotes.


:

Pssm-ID: 462710  Cd Length: 256  Bit Score: 177.99  E-value: 1.23e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966751420    1 MIQWSQFKGYFIFKLEKVMDDFRTSAPEprgppnpnvEYIPFDEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYTGT 80
Cdd:pfam09184  31 MVLWSSFKPLFREKLENVIDHFTETIPE---------EIFNLEEMKERLLDKFDGFNGAPFTIQRICELLTDPFKYYKEL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966751420   81 DKFLRGVEKNVMVVSCVYPSSEK------NNSNSLNRMNGVMfpgnspsytersningpgtPRPLNRPKVSLSAPMTTNG 154
Cdd:pfam09184 102 DKFVRALEKNCLVVSTWDPGSERsesekdNGDSSDNRINGVM-------------------PDPLDVSLVSIPWSDETNG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966751420  155 LPESTDSKE------ANLQQNEEKNHSDSSTSESEVSSVSPL----------KNKH------PDEDAVEAEGHEVKRLRF 212
Cdd:pfam09184 163 LPLSPFIKEidsimsVNFGFEDDDEDEDDDGNESGTSASESEeitlsadssfKIEEkdddeeDDEEDDDYVEDEVDDEEE 242


                  ....*....
gi 966751420  213 DKEGEVRET 221
Cdd:pfam09184 243 DDDDEEEEE 251
 
Name Accession Description Interval E-value
PPP4R2 pfam09184
PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of ...
 1-221 1.23e-53

PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex. It has been shown to confer resistance to the anticancer drug cisplatin in yeast, and may confer resistance in higher eukaryotes.


Pssm-ID: 462710  Cd Length: 256  Bit Score: 177.99  E-value: 1.23e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966751420    1 MIQWSQFKGYFIFKLEKVMDDFRTSAPEprgppnpnvEYIPFDEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYTGT 80
Cdd:pfam09184  31 MVLWSSFKPLFREKLENVIDHFTETIPE---------EIFNLEEMKERLLDKFDGFNGAPFTIQRICELLTDPFKYYKEL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966751420   81 DKFLRGVEKNVMVVSCVYPSSEK------NNSNSLNRMNGVMfpgnspsytersningpgtPRPLNRPKVSLSAPMTTNG 154
Cdd:pfam09184 102 DKFVRALEKNCLVVSTWDPGSERsesekdNGDSSDNRINGVM-------------------PDPLDVSLVSIPWSDETNG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966751420  155 LPESTDSKE------ANLQQNEEKNHSDSSTSESEVSSVSPL----------KNKH------PDEDAVEAEGHEVKRLRF 212
Cdd:pfam09184 163 LPLSPFIKEidsimsVNFGFEDDDEDEDDDGNESGTSASESEeitlsadssfKIEEkdddeeDDEEDDDYVEDEVDDEEE 242


                  ....*....
gi 966751420  213 DKEGEVRET 221
Cdd:pfam09184 243 DDDDEEEEE 251
 
Name Accession Description Interval E-value
PPP4R2 pfam09184
PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of ...
 1-221 1.23e-53

PPP4R2; PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex. It has been shown to confer resistance to the anticancer drug cisplatin in yeast, and may confer resistance in higher eukaryotes.


Pssm-ID: 462710  Cd Length: 256  Bit Score: 177.99  E-value: 1.23e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966751420    1 MIQWSQFKGYFIFKLEKVMDDFRTSAPEprgppnpnvEYIPFDEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYTGT 80
Cdd:pfam09184  31 MVLWSSFKPLFREKLENVIDHFTETIPE---------EIFNLEEMKERLLDKFDGFNGAPFTIQRICELLTDPFKYYKEL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966751420   81 DKFLRGVEKNVMVVSCVYPSSEK------NNSNSLNRMNGVMfpgnspsytersningpgtPRPLNRPKVSLSAPMTTNG 154
Cdd:pfam09184 102 DKFVRALEKNCLVVSTWDPGSERsesekdNGDSSDNRINGVM-------------------PDPLDVSLVSIPWSDETNG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966751420  155 LPESTDSKE------ANLQQNEEKNHSDSSTSESEVSSVSPL----------KNKH------PDEDAVEAEGHEVKRLRF 212
Cdd:pfam09184 163 LPLSPFIKEidsimsVNFGFEDDDEDEDDDGNESGTSASESEeitlsadssfKIEEkdddeeDDEEDDDYVEDEVDDEEE 242


                  ....*....
gi 966751420  213 DKEGEVRET 221
Cdd:pfam09184 243 DDDDEEEEE 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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