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Conserved domains on  [gi|974005284|ref|NP_001305710|]
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A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform 4 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1708-1906 2.61e-111

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


:

Pssm-ID: 462559  Cd Length: 200  Bit Score: 351.92  E-value: 2.61e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  1708 PQNCKEVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNPTECPYNGSRRDDCQC 1787
Cdd:pfam08685    1 PRSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  1788 RKDYTA-AGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWISQ 1866
Cdd:pfam08685   81 RQDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQ 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 974005284  1867 GNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRV 1906
Cdd:pfam08685  161 GNYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 293-468 9.02e-94

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


:

Pssm-ID: 239801  Cd Length: 207  Bit Score: 301.85  E-value: 9.02e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  293 RFVEVLVVADNRMV-SYHGENLQHYILTLMSI----------------------------DGPSISFNAQTTLKNFCQWQ 343
Cdd:cd04273     1 RYVETLVVADSKMVeFHHGEDLEHYILTLMNIvaslykdpslgnsinivvvrlivledeeSGLLISGNAQKSLKSFCRWQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  344 HSKNSPGG---IHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDN- 419
Cdd:cd04273    81 KKLNPPNDsdpEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDg 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 974005284  420 NKCKEEGvkSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLL 468
Cdd:cd04273   161 NSCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 49-207 8.43e-37

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


:

Pssm-ID: 460254  Cd Length: 128  Bit Score: 135.52  E-value: 8.43e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284    49 EIVSPIRVNAlgepfptnvhfKRTRRSINSATDPWPafasssssstssQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTL 128
Cdd:pfam01562    1 EVVIPVRLDP-----------SRRRRSLASESTYLD------------TLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTY 57

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 974005284   129 LGTPGVNQTKFYSEEEaelkHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSmdeqEDEEEQNKPHIIY 207
Cdd:pfam01562   58 YLDGGTGVESPPVQTD----HCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 726-843 4.67e-36

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 133.09  E-value: 4.67e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   726 TVAGTFNTVH-YGYNTVVRIPAGATNIDVRQHSFSGetdddNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGS 804
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 974005284   805 ETAVERINSTDRIEQELLLQVLSV-GKLYNPDVRYSFNIP 843
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 483-550 9.03e-19

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 82.01  E-value: 9.03e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   483 PGILYNVNKQCELIFGPGSQVCPYMMQ--CRRLWCNNVNGvhKGCRTQHTPWADGTECEPGKHCKYGFCV 550
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCSNPGG--STCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1083-1137 1.59e-18

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 80.96  E-value: 1.59e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1083 WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1137
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1358-1411 9.26e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 67.48  E-value: 9.26e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1358 WAYGNWGECTKLCGGGIRTRLVVCQRSNGER-FPDLSCEILDKPPDREQCNTHAC 1411
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1531-1584 3.03e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 3.03e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1531 WRAEEWQECTKTCGEGSRYRKVVCVD-DNKNEVHGARCDVSKRPVDRESCSLQPC 1584
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1304-1355 5.18e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.47  E-value: 5.18e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1304 WRTGPWGACSSTCAGGSQRRVVVCQDENG---YTANDCVERIKPDEQRACESGPC 1355
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 563-614 9.89e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 61.45  E-value: 9.89e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 974005284    563 WGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPC 614
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1473-1526 7.32e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 7.32e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1473 WKAGAWSQCSVSCGRGVQQRHVGCQI-GTHKIARETECNPYTRPESERDCQGPRC 1526
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1417-1470 8.31e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 8.31e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1417 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDY-CKHLAKPHGHRKCRGGRC 1470
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1028-1080 8.40e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 8.40e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1028 WKSGDWSECLVTCGKGHKHRQVWCQ--FGEDRLNDRMCDPETKPTSMQTCQQPEC 1080
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 973-1025 8.56e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 8.56e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284   973 WRYSAWTECSKSCDGGTQRRRAICVNTR-NDVLDDSKCTHQEK-VTIQRCSEFPC 1025
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKpPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 620-724 3.79e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 58.95  E-value: 3.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   620 DFRDEQCAHFDGKHFNIN-GLLPNVRW---VPKYSGILMkdrCKLFCRVAGNTAYYQLRDRVIDGTPC------GQDTND 689
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 974005284   690 ICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSC 724
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1158-1211 6.61e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.31  E-value: 6.61e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1158 WRFGSWTPCSATCGKGTRMRYVSCRDENG-SVADESACATLPRPVAKEECSVTPC 1211
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1214-1267 8.36e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.92  E-value: 8.36e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1214 WKALDWSSCSVTCGQGRATRQVMCVNYSDH-VIDRSECDQDYIPETDQDCSMSPC 1267
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1653-1701 9.11e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.23  E-value: 9.11e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 974005284  1653 WRVGNWGSCSVSCGVGVMQRSVQC---LTNEDQPSHLCHTDLKPEERKTCRN 1701
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNL 52
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1588-1647 2.75e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.68  E-value: 2.75e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974005284  1588 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYsyqttiNCPGTQ-PPSVHPCYLRDC 1647
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDS------ECSAQKkPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 857-903 2.69e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.21  E-value: 2.69e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 974005284   857 GPWQACSKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQPgHITEPC 903
Cdd:pfam19030    4 GPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSC 50
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 911-965 2.16e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 37.82  E-value: 2.16e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284   911 WHVASRSECSAQCGLGYRTLDIYCakySRLDGKtEKVDDGFCSSHPKPSNREKCS 965
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQC---VQKGGG-SIVPDSECSAQKKPPETQSCN 51
 
Name Accession Description Interval E-value
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1708-1906 2.61e-111

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


Pssm-ID: 462559  Cd Length: 200  Bit Score: 351.92  E-value: 2.61e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  1708 PQNCKEVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNPTECPYNGSRRDDCQC 1787
Cdd:pfam08685    1 PRSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  1788 RKDYTA-AGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWISQ 1866
Cdd:pfam08685   81 RQDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQ 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 974005284  1867 GNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRV 1906
Cdd:pfam08685  161 GNYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 293-468 9.02e-94

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 301.85  E-value: 9.02e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  293 RFVEVLVVADNRMV-SYHGENLQHYILTLMSI----------------------------DGPSISFNAQTTLKNFCQWQ 343
Cdd:cd04273     1 RYVETLVVADSKMVeFHHGEDLEHYILTLMNIvaslykdpslgnsinivvvrlivledeeSGLLISGNAQKSLKSFCRWQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  344 HSKNSPGG---IHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDN- 419
Cdd:cd04273    81 KKLNPPNDsdpEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDg 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 974005284  420 NKCKEEGvkSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLL 468
Cdd:cd04273   161 NSCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 49-207 8.43e-37

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 135.52  E-value: 8.43e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284    49 EIVSPIRVNAlgepfptnvhfKRTRRSINSATDPWPafasssssstssQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTL 128
Cdd:pfam01562    1 EVVIPVRLDP-----------SRRRRSLASESTYLD------------TLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTY 57

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 974005284   129 LGTPGVNQTKFYSEEEaelkHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSmdeqEDEEEQNKPHIIY 207
Cdd:pfam01562   58 YLDGGTGVESPPVQTD----HCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 726-843 4.67e-36

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 133.09  E-value: 4.67e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   726 TVAGTFNTVH-YGYNTVVRIPAGATNIDVRQHSFSGetdddNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGS 804
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 974005284   805 ETAVERINSTDRIEQELLLQVLSV-GKLYNPDVRYSFNIP 843
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 293-471 8.70e-27

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 109.70  E-value: 8.70e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   293 RFVEVLVVADNRMVSYHGENLQH---------------Y-------ILTLMSI----DGPSISFNAQTTLKNFCQWQHSk 346
Cdd:pfam01421    1 KYIELFIVVDKQLFQKMGSDTTVvrqrvfqvvnlvnsiYkelnirvVLVGLEIwtdeDKIDVSGDANDTLRNFLKWRQE- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   347 NSPGGIHHDTAVLLTRQDIcrahdKCDTLGLAELGTICDPYRSCSISEDSGLST---AFTIAHELGHVFNMPHDDNN--- 420
Cdd:pfam01421   80 YLKKRKPHDVAQLLSGVEF-----GGTTVGAAYVGGMCSLEYSGGVNEDHSKNLesfAVTMAHELGHNLGMQHDDFNggc 154

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 974005284   421 KCKEEGVkspqHVMAPTLNfYTNPWMWSKCSRKYITEFLDTGYGECLLNEP 471
Cdd:pfam01421  155 KCPPGGG----CIMNPSAG-SSFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 483-550 9.03e-19

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 82.01  E-value: 9.03e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   483 PGILYNVNKQCELIFGPGSQVCPYMMQ--CRRLWCNNVNGvhKGCRTQHTPWADGTECEPGKHCKYGFCV 550
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCSNPGG--STCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1083-1137 1.59e-18

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 80.96  E-value: 1.59e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1083 WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1137
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1358-1411 9.26e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 67.48  E-value: 9.26e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1358 WAYGNWGECTKLCGGGIRTRLVVCQRSNGER-FPDLSCEILDKPPDREQCNTHAC 1411
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1531-1584 3.03e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 3.03e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1531 WRAEEWQECTKTCGEGSRYRKVVCVD-DNKNEVHGARCDVSKRPVDRESCSLQPC 1584
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1304-1355 5.18e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.47  E-value: 5.18e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1304 WRTGPWGACSSTCAGGSQRRVVVCQDENG---YTANDCVERIKPDEQRACESGPC 1355
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 563-614 9.89e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 61.45  E-value: 9.89e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 974005284    563 WGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPC 614
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1473-1526 7.32e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 7.32e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1473 WKAGAWSQCSVSCGRGVQQRHVGCQI-GTHKIARETECNPYTRPESERDCQGPRC 1526
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1417-1470 8.31e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 8.31e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1417 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDY-CKHLAKPHGHRKCRGGRC 1470
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1028-1080 8.40e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 8.40e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1028 WKSGDWSECLVTCGKGHKHRQVWCQ--FGEDRLNDRMCDPETKPTSMQTCQQPEC 1080
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 973-1025 8.56e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 8.56e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284   973 WRYSAWTECSKSCDGGTQRRRAICVNTR-NDVLDDSKCTHQEK-VTIQRCSEFPC 1025
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKpPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 620-724 3.79e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 58.95  E-value: 3.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   620 DFRDEQCAHFDGKHFNIN-GLLPNVRW---VPKYSGILMkdrCKLFCRVAGNTAYYQLRDRVIDGTPC------GQDTND 689
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 974005284   690 ICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSC 724
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1158-1211 6.61e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.31  E-value: 6.61e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1158 WRFGSWTPCSATCGKGTRMRYVSCRDENG-SVADESACATLPRPVAKEECSVTPC 1211
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1214-1267 8.36e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.92  E-value: 8.36e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1214 WKALDWSSCSVTCGQGRATRQVMCVNYSDH-VIDRSECDQDYIPETDQDCSMSPC 1267
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1653-1701 9.11e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.23  E-value: 9.11e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 974005284  1653 WRVGNWGSCSVSCGVGVMQRSVQC---LTNEDQPSHLCHTDLKPEERKTCRN 1701
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNL 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1588-1647 2.75e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.68  E-value: 2.75e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974005284  1588 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYsyqttiNCPGTQ-PPSVHPCYLRDC 1647
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDS------ECSAQKkPPETQSCNLKPC 55
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 564-614 5.40e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.35  E-value: 5.40e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 974005284   564 GSWSPFGTCSRTCGGGIKTAIRECNRPePKNGGKYCvGRRMKFKSCNTEPC 614
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 1171-1289 2.25e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 49.19  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284 1171 GKGTRMRY----VSCRDENG-----SVADESACATLPRPVAKEECS----VTPCGQWKalDWSSCSVTCGQGRATRQ--V 1235
Cdd:PTZ00441  187 GQGINHQFnrllAGCRPREGkckfySDADWEEAKNLIKPFIAKVCTeverTASCGPWD--EWTPCSVTCGKGTHSRSrpI 264

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 974005284 1236 MCVNYSDHVIdrSECDQDyipetdqDCSMSPCPQRTPDsglaQHPFQNEDYRPR 1289
Cdd:PTZ00441  265 LHEGCTTHMV--EECEEE-------ECPVEPEPLPVPA----PVPPTPEDDNPR 305
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1211-1268 2.31e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 43.34  E-value: 2.31e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 974005284   1211 CGQWKalDWSSCSVTCGQGRATRQVMCVNYSDHViDRSECDQDYiPETdQDCSMSPCP 1268
Cdd:smart00209    1 WSEWS--EWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGED-VET-RACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 973-1026 2.60e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 43.34  E-value: 2.60e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 974005284    973 WRYSAWTECSKSCDGGTQRRRAICVNTRNDVlDDSKCTHQeKVTIQRCSEFPCP 1026
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGE-DVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 857-903 2.69e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.21  E-value: 2.69e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 974005284   857 GPWQACSKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQPgHITEPC 903
Cdd:pfam19030    4 GPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSC 50
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1158-1211 5.32e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.57  E-value: 5.32e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 974005284   1158 WRFGSWTPCSATCGKGTRMRYVSCRDENGSVaDESACATLPRpvAKEECSVTPC 1211
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1534-1585 6.35e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.19  E-value: 6.35e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 974005284   1534 EEWQECTKTCGEGSRYRKVVCVdDNKNEVHGARCDVSKRpvDRESCSLQPCE 1585
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCC-SPPPQNGGGPCTGEDV--ETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1031-1075 1.51e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.03  E-value: 1.51e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 974005284   1031 GDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMC---DPETKPTSMQTC 1075
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCtgeDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1358-1412 1.70e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.03  E-value: 1.70e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284   1358 WAYGNWGECTKLCGGGIRTRLVVCQrSNGERFPDLSCEILDkpPDREQCNTHACP 1412
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCC-SPPPQNGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1304-1356 5.69e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.49  E-value: 5.69e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 974005284   1304 WRTGPWGACSSTCAGGSQRRVVVCQDENGYT-ANDCVEriKPDEQRACESGPCP 1356
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNgGGPCTG--EDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1417-1471 6.60e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.49  E-value: 6.60e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284   1417 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDyCKHLAKPhgHRKCRGGRCP 1471
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGP-CTGEDVE--TRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1476-1527 1.17e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 1.17e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 974005284   1476 GAWSQCSVSCGRGVQQRHVGCqIGTHKIARETECNPYTRpeSERDCQGPRCP 1527
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSC-CSPPPQNGGGPCTGEDV--ETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 911-965 2.16e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 37.82  E-value: 2.16e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284   911 WHVASRSECSAQCGLGYRTLDIYCakySRLDGKtEKVDDGFCSSHPKPSNREKCS 965
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQC---VQKGGG-SIVPDSECSAQKKPPETQSCN 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1587-1612 3.42e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 3.42e-03
                            10        20
                    ....*....|....*....|....*.
gi 974005284   1587 VWITGEWSECSVTCGKGYKQRLVSCS 1612
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCC 26
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1086-1138 8.22e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 8.22e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 974005284   1086 GPWGQCSVTCGQGYQLRAVKCIIGTymSVVDDNDCNAATRptDTQDCELPSCH 1138
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPP--PQNGGGPCTGEDV--ETRACNEQPCP 53
 
Name Accession Description Interval E-value
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1708-1906 2.61e-111

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


Pssm-ID: 462559  Cd Length: 200  Bit Score: 351.92  E-value: 2.61e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  1708 PQNCKEVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNPTECPYNGSRRDDCQC 1787
Cdd:pfam08685    1 PRSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCAC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  1788 RKDYTA-AGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWISQ 1866
Cdd:pfam08685   81 RQDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQ 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 974005284  1867 GNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRV 1906
Cdd:pfam08685  161 GNYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 293-468 9.02e-94

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 301.85  E-value: 9.02e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  293 RFVEVLVVADNRMV-SYHGENLQHYILTLMSI----------------------------DGPSISFNAQTTLKNFCQWQ 343
Cdd:cd04273     1 RYVETLVVADSKMVeFHHGEDLEHYILTLMNIvaslykdpslgnsinivvvrlivledeeSGLLISGNAQKSLKSFCRWQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  344 HSKNSPGG---IHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDN- 419
Cdd:cd04273    81 KKLNPPNDsdpEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDg 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 974005284  420 NKCKEEGvkSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLL 468
Cdd:cd04273   161 NSCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 293-460 3.98e-55

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 190.71  E-value: 3.98e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  293 RFVEVLVVADNRMVSY---HGENLQHYILTLMSI----------------------------DGPSISFNAQTTLKNFCQ 341
Cdd:cd04267     1 REIELVVVADHRMVSYfnsDENILQAYITELINIansiyrstnlrlgirisleglqilkgeqFAPPIDSDASNTLNSFSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  342 WQHSknspGGIHHDTAVLLTRQDIcrahDKCDTLGLAELGTICDPYRSCSISEDSG--LSTAFTIAHELGHVFNMPHDDN 419
Cdd:cd04267    81 WRAE----GPIRHDNAVLLTAQDF----IEGDILGLAYVGSMCNPYSSVGVVEDTGftLLTALTMAHELGHNLGAEHDGG 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 974005284  420 NKCKEEGVKSPQHVMAPTLNFyTNPWMWSKCSRKYITEFLD 460
Cdd:cd04267   153 DELAFECDGGGNYIMAPVDSG-LNSYRFSQCSIGSIREFLD 192
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 49-207 8.43e-37

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 135.52  E-value: 8.43e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284    49 EIVSPIRVNAlgepfptnvhfKRTRRSINSATDPWPafasssssstssQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTL 128
Cdd:pfam01562    1 EVVIPVRLDP-----------SRRRRSLASESTYLD------------TLSYRLAAFGKKFHLHLTPNRLLLAPGFTVTY 57

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 974005284   129 LGTPGVNQTKFYSEEEaelkHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSmdeqEDEEEQNKPHIIY 207
Cdd:pfam01562   58 YLDGGTGVESPPVQTD----HCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 726-843 4.67e-36

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 133.09  E-value: 4.67e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   726 TVAGTFNTVH-YGYNTVVRIPAGATNIDVRQHSFSGetdddNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGS 804
Cdd:pfam05986    1 TVSGSFTEGRaKGYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRS 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 974005284   805 ETAVERINSTDRIEQELLLQVLSV-GKLYNPDVRYSFNIP 843
Cdd:pfam05986   76 LPALEELHAPGPTQEDLEIQVLRQyGKGTNPGITYEYFIP 115
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 293-469 1.61e-32

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 125.81  E-value: 1.61e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  293 RFVEVLVVADNRMVSYHGENLQ----------------------HYILTLMSI--DGPSISF--NAQTTLKNFCQWQHSK 346
Cdd:cd04269     1 KYVELVVVVDNSLYKKYGSNLSkvrqrvieivnivdsiyrplniRVVLVGLEIwtDKDKISVsgDAGETLNRFLDWKRSN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  347 NSPGgIHHDTAVLLTRQDICRahdkcDTLGLAELGTICDPYRSCSISEDSG---LSTAFTIAHELGHVFNMPHDDNN-KC 422
Cdd:cd04269    81 LLPR-KPHDNAQLLTGRDFDG-----NTVGLAYVGGMCSPKYSGGVVQDHSrnlLLFAVTMAHELGHNLGMEHDDGGcTC 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 974005284  423 KEEGVkspqhVMAPTLNFYTnpWMWSKCSRKYITEFLDTGYGECLLN 469
Cdd:cd04269   155 GRSTC-----IMAPSPSSLT--DAFSNCSYEDYQKFLSRGGGQCLLN 194
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 293-459 1.45e-29

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 116.47  E-value: 1.45e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  293 RFVEVLVVADNRMvsYHGENLQHYILTLMSIdgpSISFNAQTTLKNFcqwqhsKNSPGGI-HHDTAVLLTRQDIcrahdK 371
Cdd:cd00203     1 KVIPYVVVADDRD--VEEENLSAQIQSLILI---AMQIWRDYLNIRF------VLVGVEIdKADIAILVTRQDF-----D 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  372 CDTLGLAELGTICDPYRSCSISEDSGLST---AFTIAHELGHVFNMPHDDNNKCKEEGVKS----------PQHVMAPTL 438
Cdd:cd00203    65 GGTGGWAYLGRVCDSLRGVGVLQDNQSGTkegAQTIAHELGHALGFYHDHDRKDRDDYPTIddtlnaedddYYSVMSYTK 144

                         170       180
                  ....*....|....*....|...
gi 974005284  439 NFYT--NPWMWSKCSRKYITEFL 459
Cdd:cd00203   145 GSFSdgQRKDFSQCDIDQINKLY 167
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 293-471 8.70e-27

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 109.70  E-value: 8.70e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   293 RFVEVLVVADNRMVSYHGENLQH---------------Y-------ILTLMSI----DGPSISFNAQTTLKNFCQWQHSk 346
Cdd:pfam01421    1 KYIELFIVVDKQLFQKMGSDTTVvrqrvfqvvnlvnsiYkelnirvVLVGLEIwtdeDKIDVSGDANDTLRNFLKWRQE- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   347 NSPGGIHHDTAVLLTRQDIcrahdKCDTLGLAELGTICDPYRSCSISEDSGLST---AFTIAHELGHVFNMPHDDNN--- 420
Cdd:pfam01421   80 YLKKRKPHDVAQLLSGVEF-----GGTTVGAAYVGGMCSLEYSGGVNEDHSKNLesfAVTMAHELGHNLGMQHDDFNggc 154

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 974005284   421 KCKEEGVkspqHVMAPTLNfYTNPWMWSKCSRKYITEFLDTGYGECLLNEP 471
Cdd:pfam01421  155 KCPPGGG----CIMNPSAG-SSFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 483-550 9.03e-19

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 82.01  E-value: 9.03e-19
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   483 PGILYNVNKQCELIFGPGSQVCPYMMQ--CRRLWCNNVNGvhKGCRTQHTPWADGTECEPGKHCKYGFCV 550
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCSNPGG--STCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1083-1137 1.59e-18

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 80.96  E-value: 1.59e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1083 WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1137
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1358-1411 9.26e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 67.48  E-value: 9.26e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1358 WAYGNWGECTKLCGGGIRTRLVVCQRSNGER-FPDLSCEILDKPPDREQCNTHAC 1411
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSiVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1531-1584 3.03e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.86  E-value: 3.03e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1531 WRAEEWQECTKTCGEGSRYRKVVCVD-DNKNEVHGARCDVSKRPVDRESCSLQPC 1584
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1304-1355 5.18e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.47  E-value: 5.18e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1304 WRTGPWGACSSTCAGGSQRRVVVCQDENG---YTANDCVERIKPDEQRACESGPC 1355
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgsiVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 563-614 9.89e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 61.45  E-value: 9.89e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 974005284    563 WGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPC 614
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1473-1526 7.32e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 7.32e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1473 WKAGAWSQCSVSCGRGVQQRHVGCQI-GTHKIARETECNPYTRPESERDCQGPRC 1526
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1417-1470 8.31e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 8.31e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1417 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDY-CKHLAKPHGHRKCRGGRC 1470
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDSeCSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1028-1080 8.40e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 8.40e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1028 WKSGDWSECLVTCGKGHKHRQVWCQ--FGEDRLNDRMCDPETKPTSMQTCQQPEC 1080
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 973-1025 8.56e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.00  E-value: 8.56e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284   973 WRYSAWTECSKSCDGGTQRRRAICVNTR-NDVLDDSKCTHQEK-VTIQRCSEFPC 1025
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKpPETQSCNLKPC 55
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 294-467 8.75e-11

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 63.91  E-value: 8.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  294 FVEVLVVADNRMVSYHGENLQ--HYILTLM--------SIDGPSISF-------------------------NAQTTLKN 338
Cdd:cd04272     2 YPELFVVVDYDHQSEFFSNEQliRYLAVMVnaanlryrDLKSPRIRLllvgitiskdpdfepyihpinygyiDAAETLEN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  339 FCQWQHSKNSPGgiHHDTAVLLTRQDICRAHD-KCDT--LGLAELGTICDPYRsCSISEDSGLS--TAFTIAHELGHVFN 413
Cdd:cd04272    82 FNEYVKKKRDYF--NPDVVFLVTGLDMSTYSGgSLQTgtGGYAYVGGACTENR-VAMGEDTPGSyyGVYTMTHELAHLLG 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 974005284  414 MPHDD---NNKCK----------EEGvkspqHVMApTLNFYTNPWMWSKCSRKYITEFLDTGYGECL 467
Cdd:cd04272   159 APHDGsppPSWVKghpgsldcpwDDG-----YIMS-YVVNGERQYRFSQCSQRQIRNVFRRLGASCL 219
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 620-724 3.79e-10

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 58.95  E-value: 3.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   620 DFRDEQCAHFDGKHFNIN-GLLPNVRW---VPKYSGILMkdrCKLFCRVAGNTAYYQLRDRVIDGTPC------GQDTND 689
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCmpsgprEDGTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 974005284   690 ICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSC 724
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1158-1211 6.61e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 56.31  E-value: 6.61e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1158 WRFGSWTPCSATCGKGTRMRYVSCRDENG-SVADESACATLPRPVAKEECSVTPC 1211
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGgSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1214-1267 8.36e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 55.92  E-value: 8.36e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284  1214 WKALDWSSCSVTCGQGRATRQVMCVNYSDH-VIDRSECDQDYIPETDQDCSMSPC 1267
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1653-1701 9.11e-09

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 53.23  E-value: 9.11e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 974005284  1653 WRVGNWGSCSVSCGVGVMQRSVQC---LTNEDQPSHLCHTDLKPEERKTCRN 1701
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKKPPETQSCNL 52
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 293-417 2.02e-08

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 54.30  E-value: 2.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   293 RFVEVLVVADNRMVSYHGE--NLQHYILTLmSIDGPSISFNAQTTLKNFCQWQHskNSPGGIHHDTAVLLTRQDicrahd 370
Cdd:pfam13582    2 RIVSLVNRANTIYERDLGIrlQLAAIIITT-SADTPYTSSDALEILDELQEVND--TRIGQYGYDLGHLFTGRD------ 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 974005284   371 KCDTLGLAELGTICDPYRSCSISEDS---GLSTAFTIAHELGHVFNMPHD 417
Cdd:pfam13582   73 GGGGGGIAYVGGVCNSGSKFGVNSGSgpvGDTGADTFAHEIGHNFGLNHT 122
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1588-1647 2.75e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 51.68  E-value: 2.75e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974005284  1588 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYsyqttiNCPGTQ-PPSVHPCYLRDC 1647
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIVPDS------ECSAQKkPPETQSCNLKPC 55
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
291-445 1.05e-06

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 51.27  E-value: 1.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   291 YPRFVEVLVVADNRMVSYH-GENLQHYILTLM----------------------------SIDGPSISFNAQTTLKNFcQ 341
Cdd:pfam13688    1 STRTVALLVAADCSYVAAFgGDAAQANIINMVntasnvyerdfnislglvnltisdstcpYTPPACSTGDSSDRLSEF-Q 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   342 WQHSKNspGGIHHDTAVLLTrqdicraHDKCDTLGLAELGTICDPYRSCSISEDSG--------LSTAFTIAHELGHVFN 413
Cdd:pfam13688   80 DFSAWR--GTQNDDLAYLFL-------MTNCSGGGLAWLGQLCNSGSAGSVSTRVSgnnvvvstATEWQVFAHEIGHNFG 150

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 974005284   414 MPHDDNNKCKEEG--------VKSPQHVMAPTLNFYTNPW 445
Cdd:pfam13688  151 AVHDCDSSTSSQCcppsnstcPAGGRYIMNPSSSPNSTDF 190
ZnMc_TACE_like cd04270
Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha ...
 364-473 4.01e-06

Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.


Pssm-ID: 239798 [Multi-domain]  Cd Length: 244  Bit Score: 50.06  E-value: 4.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284  364 DICRAHDKCD------TLGLAELGT--------ICDPYRSCS----ISEDSGLSTAF-------------TIAHELGHVF 412
Cdd:cd04270   100 DVCLAHLFTYrdfdmgTLGLAYVGSprdnsaggICEKAYYYSngkkKYLNTGLTTTVnygkrvptkesdlVTAHELGHNF 179

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 974005284  413 NMPHD-DNNKCKEEGVKSPQHVMAP--TLNFYTNPWMWSKCSRKYITEFLDTGYGEClLNEPES 473
Cdd:cd04270   180 GSPHDpDIAECAPGESQGGNYIMYAraTSGDKENNKKFSPCSKKSISKVLEVKSNSC-FVERSQ 242
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 564-614 5.40e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.35  E-value: 5.40e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 974005284   564 GSWSPFGTCSRTCGGGIKTAIRECNRPePKNGGKYCvGRRMKFKSCNTEPC 614
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 1171-1289 2.25e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 49.19  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284 1171 GKGTRMRY----VSCRDENG-----SVADESACATLPRPVAKEECS----VTPCGQWKalDWSSCSVTCGQGRATRQ--V 1235
Cdd:PTZ00441  187 GQGINHQFnrllAGCRPREGkckfySDADWEEAKNLIKPFIAKVCTeverTASCGPWD--EWTPCSVTCGKGTHSRSrpI 264

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 974005284 1236 MCVNYSDHVIdrSECDQDyipetdqDCSMSPCPQRTPDsglaQHPFQNEDYRPR 1289
Cdd:PTZ00441  265 LHEGCTTHMV--EECEEE-------ECPVEPEPLPVPA----PVPPTPEDDNPR 305
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1211-1268 2.31e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 43.34  E-value: 2.31e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 974005284   1211 CGQWKalDWSSCSVTCGQGRATRQVMCVNYSDHViDRSECDQDYiPETdQDCSMSPCP 1268
Cdd:smart00209    1 WSEWS--EWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGED-VET-RACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 973-1026 2.60e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 43.34  E-value: 2.60e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 974005284    973 WRYSAWTECSKSCDGGTQRRRAICVNTRNDVlDDSKCTHQeKVTIQRCSEFPCP 1026
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGE-DVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 857-903 2.69e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.21  E-value: 2.69e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 974005284   857 GPWQACSKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQPgHITEPC 903
Cdd:pfam19030    4 GPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSAQKKP-PETQSC 50
Reprolysin_2 pfam13574
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 339-459 3.61e-05

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 372637  Cd Length: 193  Bit Score: 46.47  E-value: 3.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005284   339 FCQWQHSKNspggihHDTAVLLTRQDICRAhdkcdTLGLAELGTICDPYRSCsISEDSGLSTAFT-------------IA 405
Cdd:pfam13574   62 LSQWRGEQD------YCLAHLVTMGTFSGG-----ELGLAYVGQICQKGASS-PKTNTGLSTTTNygsfnyptqewdvVA 129

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 974005284   406 HELGHVFNMPHDDN------NKCKEEGVKSP-----QHVMAPT---LNFytnpwMWSKCSRKYITEFL 459
Cdd:pfam13574  130 HEVGHNFGATHDCDgsqyasSGCERNAATSVcsangSFIMNPAsksNND-----LFSPCSISLICDVL 192
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1158-1211 5.32e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.57  E-value: 5.32e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 974005284   1158 WRFGSWTPCSATCGKGTRMRYVSCRDENGSVaDESACATLPRpvAKEECSVTPC 1211
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTGEDV--ETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1534-1585 6.35e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 42.19  E-value: 6.35e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 974005284   1534 EEWQECTKTCGEGSRYRKVVCVdDNKNEVHGARCDVSKRpvDRESCSLQPCE 1585
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCC-SPPPQNGGGPCTGEDV--ETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
563-614 6.52e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 42.02  E-value: 6.52e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 974005284   563 WGSWSPfgtCSRTCGGGIKTAIRECNRPEPknGGKYCVGRRMKFKSCNTEPC 614
Cdd:pfam00090    3 WSPWSP---CSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1031-1075 1.51e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.03  E-value: 1.51e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 974005284   1031 GDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMC---DPETKPTSMQTC 1075
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCtgeDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1358-1412 1.70e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 41.03  E-value: 1.70e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284   1358 WAYGNWGECTKLCGGGIRTRLVVCQrSNGERFPDLSCEILDkpPDREQCNTHACP 1412
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCC-SPPPQNGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1304-1356 5.69e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.49  E-value: 5.69e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 974005284   1304 WRTGPWGACSSTCAGGSQRRVVVCQDENGYT-ANDCVEriKPDEQRACESGPCP 1356
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNgGGPCTG--EDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1417-1471 6.60e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.49  E-value: 6.60e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284   1417 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDyCKHLAKPhgHRKCRGGRCP 1471
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGP-CTGEDVE--TRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1476-1527 1.17e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 1.17e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 974005284   1476 GAWSQCSVSCGRGVQQRHVGCqIGTHKIARETECNPYTRpeSERDCQGPRCP 1527
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSC-CSPPPQNGGGPCTGEDV--ETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1160-1181 1.17e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 38.55  E-value: 1.17e-03
                           10        20
                   ....*....|....*....|..
gi 974005284  1160 FGSWTPCSATCGKGTRMRYVSC 1181
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTC 24
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 911-965 2.16e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 37.82  E-value: 2.16e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 974005284   911 WHVASRSECSAQCGLGYRTLDIYCakySRLDGKtEKVDDGFCSSHPKPSNREKCS 965
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQC---VQKGGG-SIVPDSECSAQKKPPETQSCN 51
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 968-1025 3.13e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.26  E-value: 3.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 974005284   968 CNTGGWrySAWTECSKSCDGGTQRR-RAICVNTRNdvlDDSKCTHQEKVtiQRCSEFPC 1025
Cdd:pfam19028    1 CVVSEW--SEWSECSVTCGGGVQTRtRTVIVEPQN---GGRPCPELLER--RPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1587-1612 3.42e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 3.42e-03
                            10        20
                    ....*....|....*....|....*.
gi 974005284   1587 VWITGEWSECSVTCGKGYKQRLVSCS 1612
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCC 26
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1160-1211 6.75e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.49  E-value: 6.75e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 974005284  1160 FGSWTPCSATCGKG--TRMRYVSCRDENGSvadeSACatlPRPVAKEECSVTPC 1211
Cdd:pfam19028    6 WSEWSECSVTCGGGvqTRTRTVIVEPQNGG----RPC---PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1086-1138 8.22e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 8.22e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 974005284   1086 GPWGQCSVTCGQGYQLRAVKCIIGTymSVVDDNDCNAATRptDTQDCELPSCH 1138
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSCCSPP--PQNGGGPCTGEDV--ETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1590-1611 8.69e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 36.24  E-value: 8.69e-03
                           10        20
                   ....*....|....*....|..
gi 974005284  1590 TGEWSECSVTCGKGYKQRLVSC 1611
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTC 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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