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Conserved domains on  [gi|973757891|ref|NP_001305738|]
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TBC1 domain family member 7 [Homo sapiens]

Protein Classification

TBC domain-containing protein( domain architecture ID 771)

TBC (Tre-2, BUB2p, Cdc16p) domain-containing protein may perform a GTP-activator activity on Rab-like GTPases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RabGAP-TBC super family cl46302
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 145-251 2.25e-05

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


The actual alignment was detected with superfamily member pfam00566:

Pssm-ID: 480642  Cd Length: 178  Bit Score: 44.17  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973757891  145 VEDSVDCYWITRRFVN--QLNTKYRDSLPQLPKA---FEQYLNLEDGRLLTHLRMCSAAPKLPYDLWFKRCFAGCLPESS 219
Cdd:pfam00566  66 YLDEEDAFWCFVSLLEnyLLRDFYTPDFPGLKRDlyvFEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLST 145

                          90       100       110
                  ....*....|....*....|....*....|...
gi 973757891  220 LQRVWDKV-VSGSCKILVFVAVEILLTFKIKVM 251
Cdd:pfam00566 146 VLRIWDYFfLEGEKFVLFRVALAILKRFREELL 178
 
Name Accession Description Interval E-value
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 145-251 2.25e-05

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 44.17  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973757891  145 VEDSVDCYWITRRFVN--QLNTKYRDSLPQLPKA---FEQYLNLEDGRLLTHLRMCSAAPKLPYDLWFKRCFAGCLPESS 219
Cdd:pfam00566  66 YLDEEDAFWCFVSLLEnyLLRDFYTPDFPGLKRDlyvFEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLST 145

                          90       100       110
                  ....*....|....*....|....*....|...
gi 973757891  220 LQRVWDKV-VSGSCKILVFVAVEILLTFKIKVM 251
Cdd:pfam00566 146 VLRIWDYFfLEGEKFVLFRVALAILKRFREELL 178
COG5210 COG5210
GTPase-activating protein [General function prediction only];
206-285 8.11e-04

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 40.56  E-value: 8.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973757891 206 WFKRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKH 285
Cdd:COG5210  382 WFLTLFVREFPLEYALRIWDCLFLEGSSMLFQLALAILKLLRDKLLKLDSDELLDLLLKQLFLHSGKEAWSSILKFRHGT 461
 
Name Accession Description Interval E-value
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 145-251 2.25e-05

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 44.17  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973757891  145 VEDSVDCYWITRRFVN--QLNTKYRDSLPQLPKA---FEQYLNLEDGRLLTHLRMCSAAPKLPYDLWFKRCFAGCLPESS 219
Cdd:pfam00566  66 YLDEEDAFWCFVSLLEnyLLRDFYTPDFPGLKRDlyvFEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLST 145

                          90       100       110
                  ....*....|....*....|....*....|...
gi 973757891  220 LQRVWDKV-VSGSCKILVFVAVEILLTFKIKVM 251
Cdd:pfam00566 146 VLRIWDYFfLEGEKFVLFRVALAILKRFREELL 178
COG5210 COG5210
GTPase-activating protein [General function prediction only];
206-285 8.11e-04

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 40.56  E-value: 8.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973757891 206 WFKRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKH 285
Cdd:COG5210  382 WFLTLFVREFPLEYALRIWDCLFLEGSSMLFQLALAILKLLRDKLLKLDSDELLDLLLKQLFLHSGKEAWSSILKFRHGT 461
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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