meprin and TRAF homology;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303    9 VITQSVKNVSSIADGGEHVTPSEIHYGTEWYMRIKRDNGFMSFGLYCPMTGKTT-NWSIVADIRVELMPLTGMWKSVECE 87
Cdd:smart00061   1 VLSHTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCEKEECDSrKWSIEAEFTLKLVSQNGKSLSKKDK 80

                   ....*.
gi 1017368303   88 CKIAKS 93
Cdd:smart00061  81 HVFEKP 86

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303  153 DVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDSA-INDLTVEGILHIADMY 231
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLdLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 1017368303  232 DTPMVVRKCEEFLIKGT 248
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

meprin and TRAF homology;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303    9 VITQSVKNVSSIADGGEHVTPSEIHYGTEWYMRIKRDNGFMSFGLYCPMTGKTT-NWSIVADIRVELMPLTGMWKSVECE 87
Cdd:smart00061   1 VLSHTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCEKEECDSrKWSIEAEFTLKLVSQNGKSLSKKDK 80

                   ....*.
gi 1017368303   88 CKIAKS 93
Cdd:smart00061  81 HVFEKP 86

MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303  11 TQSVKNVS-SIADGGEHVTPSEIHYGTEWYMRIKRDN-----GFMSFGLYCpMTGKTT--NWSIVADIRVELMPLTGmWK 82
Cdd:cd00121     2 KHTWKIVNfSELEGESIYSPPFEVGGYKWRIRIYPNGdgesgDYLSLYLEL-DKGESDleKWSVRAEFTLKLVNQNG-GK 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1017368303  83 SVECECKIAKSPSLISEVLRSTIMPWGRMMTNY-VVDDALMIEVFVT 128
Cdd:cd00121    80 SLSKSFTHVFFSEKGSGWGFPKFISWDDLEDSYyLVDDSLTIEVEVK 126

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303  153 DVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDSA-INDLTVEGILHIADMY 231
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLdLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 1017368303  232 DTPMVVRKCEEFLIKGT 248
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 151 FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIAD 229
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYtGELELSEENVEELLAAAD 80

                  ..
gi 1017368303 230 MY 231
Cdd:cd18186    81 KL 82

meprin and TRAF homology;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303    9 VITQSVKNVSSIADGGEHVTPSEIHYGTEWYMRIKRDNGFMSFGLYCPMTGKTT-NWSIVADIRVELMPLTGMWKSVECE 87
Cdd:smart00061   1 VLSHTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCEKEECDSrKWSIEAEFTLKLVSQNGKSLSKKDK 80

                   ....*.
gi 1017368303   88 CKIAKS 93
Cdd:smart00061  81 HVFEKP 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1017368303 154 VVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDSAINDL-TVEGILHIADMY 231
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDAsNLLELLEAANFL 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 149 EEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDL---TVEGI 224
Cdd:cd18287    20 EEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYtGRLTLTDLkedVLLDV 99

                  ....*...
gi 1017368303 225 LHIADMYD 232
Cdd:cd18287   100 LGLAHQYG 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 151 FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIAD 229
Cdd:cd18340    27 FVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYtSEIEITEQNVQDIFAAAN 106

                          90
                  ....*....|....*..
gi 1017368303 230 MYDTPMVVRKCEEFLIK 246
Cdd:cd18340   107 MFQIPSIFTVCVSFLQK 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 151 FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIAD 229
Cdd:cd18269    27 FVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYtSEIDLNDQNVQDIFALAS 106

                          90
                  ....*....|....*..
gi 1017368303 230 MYDTPMVVRKCEEFLIK 246
Cdd:cd18269   107 RFQIPSIFTVCVSYLQK 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 151 FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTL-TSIDPNDFQFFLEVLYGDSA-INDLTVEGILHIA 228
Cdd:cd18267    40 FTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFhDSIHPEVLELLLDYAYSSRViINEENAESLLEAG 119

                          90
                  ....*....|....*...
gi 1017368303 229 DMYDTPMVVRKCEEFLIK 246
Cdd:cd18267   120 DMLEFQDIRDACAEFLEK 137

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 152 SDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIADM 230
Cdd:cd18234     2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYtGRLELKEDNVESLLATACL 81

                          90
                  ....*....|....*.
gi 1017368303 231 YDTPMVVRKCEEFLIK 246
Cdd:cd18234    82 LQLSEVVEACCGFLMK 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 150 EFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIA 228
Cdd:cd18259    31 KLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYtGKLTINQGNVEALIRTS 110

                          90
                  ....*....|....*.
gi 1017368303 229 DMYDTPMVVRKCEEFL 244
Cdd:cd18259   111 NRLQFPTVRKVCSRYL 126

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 149 EEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDSA--INDLTVEGILH 226
Cdd:cd18300     7 GLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQApiLEDGDCVGLIV 86

                          90       100
                  ....*....|....*....|.
gi 1017368303 227 IADMYDTPMVVRKCEEFLIKG 247
Cdd:cd18300    87 LANRLCLPRLVALCEQYIVKE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 149 EEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLL-GSFEEGKSSEVTLTSiDPN---DFQFFLEVLY-GDSAINDLTVEG 223
Cdd:cd18292    15 EELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSnDWWSESKQSEIELVE-DPEcaaVFEKFLRYLYtGQISVNLETALP 93

                          90       100
                  ....*....|....*....|
gi 1017368303 224 ILHIADMYDTPMVVRKCEEF 243
Cdd:cd18292    94 LLMLADKYNVTDLKQLCVDF 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 141 LRSFDESMEE--FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAIN 217
Cdd:cd18250     9 LRGLSELRAErkFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYtGRVTVT 88

                          90       100
                  ....*....|....*....|....*..
gi 1017368303 218 DLTVEGILHIADMYDTPMVVRKCEEFL 244
Cdd:cd18250    89 QDNVEALLRAADLFQFPSVKEACCAYL 115

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 140 NLRSFDESMEEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEE-----GKSSEVTLTSIDPNDFQFFLEVLYGDS 214
Cdd:cd18296     6 ELPFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAEseennGSIPVVTLHDVSPEVFAIVLYYIYTDD 85

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1017368303 215 A-INDLTVEGILHIADMYDTPMVVRKCEEFLIK 246
Cdd:cd18296    86 TdLPPENAYDVLYVADMYLLPGLKRLCGTVLAQ 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 150 EFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIA 228
Cdd:cd18341    26 KFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYsAEIDLNDGNVQDIFALA 105

                          90
                  ....*....|....*...
gi 1017368303 229 DMYDTPMVVRKCEEFLIK 246
Cdd:cd18341   106 SRFQIPSVFTVCVTYLQK 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 141 LRSFDESMEE--FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDF-QFFLEVLYGDSAIN 217
Cdd:cd18268    11 LRQLNSLRQEriLTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLdQIVDYVYTGEILIT 90

                          90       100
                  ....*....|....*....|....*..
gi 1017368303 218 DLTVEGILHIADMYDTPMVVRKCEEFL 244
Cdd:cd18268    91 RDNVLPLMEAASMLQYPKLFEACSLYL 117

MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303  11 TQSVKNVS-SIADGGEHVTPSEIHYGTEWYMRIKRDN-----GFMSFGLYCpMTGKTT--NWSIVADIRVELMPLTGmWK 82
Cdd:cd00121     2 KHTWKIVNfSELEGESIYSPPFEVGGYKWRIRIYPNGdgesgDYLSLYLEL-DKGESDleKWSVRAEFTLKLVNQNG-GK 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1017368303  83 SVECECKIAKSPSLISEVLRSTIMPWGRMMTNY-VVDDALMIEVFVT 128
Cdd:cd00121    80 SLSKSFTHVFFSEKGSGWGFPKFISWDDLEDSYyLVDDSLTIEVEVK 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 151 FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIAD 229
Cdd:cd18253    18 FTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYtGKVKITTENVQYLFETSS 97

                          90
                  ....*....|....*
gi 1017368303 230 MYDTPMVVRKCEEFL 244
Cdd:cd18253    98 LFQISPLRDACAKFL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 149 EEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDSAIN-DLTVEGILHI 227
Cdd:cd18279    16 SRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNlDKMADDLLAA 95

                          90
                  ....*....|....*..
gi 1017368303 228 ADMYDTPMVVRKCEEFL 244
Cdd:cd18279    96 ADKYALERLKVMCEDAL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 150 EFSDVVLLVGEKKFYVLRKYLAaQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYG-----DSAINDLTVEGI 224
Cdd:cd18305    14 ENSDITICALGREWKLHKIYLC-QSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVVFGslyrdEIEIKPSRVVSI 92

                          90       100
                  ....*....|....*....|.
gi 1017368303 225 LHIADMYDTPMVVRKCEEFLI 245
Cdd:cd18305    93 LAAATLLQLDGLIQQCSEVMK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 149 EEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLYGDSAIN-DLTVEGILHI 227
Cdd:cd18345    16 SAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAPNlDKMADDLLAA 95

                          90
                  ....*....|....*..
gi 1017368303 228 ADMYDTPMVVRKCEEFL 244
Cdd:cd18345    96 ADKYALERLKVMCEEAL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 163 FYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTVEGILHIADMYDTPMVVRKCE 241
Cdd:cd18273    46 FPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDYCYtGRVTLSEANVQRLYAAANMLQLEYVREACA 125

                  ....*
gi 1017368303 242 EFLIK 246
Cdd:cd18273   126 SFLAR 130

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 145 DESMEE--FSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDLTV 221
Cdd:cd18272    24 DLCLEDglFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYhGTVKLRVEEL 103

                          90       100
                  ....*....|....*....|....*
gi 1017368303 222 EGILHIADMYDTPMVVRKCEEFLIK 246
Cdd:cd18272   104 QETYEVADMYQLTALFEECSRFLAR 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017368303 141 LRSFDESmEEFSDVVLLVGEKKFYVLRKYLAAQSKYFKALLLGSFEEGKSSEVTLTSIDPNDFQFFLEVLY-GDSAINDL 219
Cdd:cd18271    15 LQNFREQ-NAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYtGKAEITDD 93

                          90       100
                  ....*....|....*....|....*..
gi 1017368303 220 TVEGILHIADMYDTPMVVRKCEEFLIK 246
Cdd:cd18271    94 NVEMFFQMSSFLQVSLLSKACSDFLIK 120