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Conserved domains on  [gi|1063728858|ref|NP_001318555|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 134-415 4.64e-69

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 4.64e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 134 RCSINRVLWTPSGRRLITGSQSGEFTLWNGQSFNFEMILQAHDQPIRSMVWSHNENYMVSGDDGGTLKYWQNNMNNVKAN 213
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 214 KTAHKESIRDLSFCKTDLKFCSCSDDTTVKVWDFTKCVDESSLTGHGWDVKSVDWHPTKSLLVSGGKDQLVKLWDTRSGR 293
Cdd:cd00200    89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 294 ELCSLHGHKNIVLSVKWNQNGNWLLTASKDQIIKLYDIRTMKELQSFRGHTKDVTSLAWHPcHEEYFVSGSSDGSICHWI 373
Cdd:cd00200   169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWD 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1063728858 374 VGHENPQIEIPnAHDNSVWDLAWHPIGYLLCSGSNDHTTKFW 415
Cdd:cd00200   248 LRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 134-415 4.64e-69

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 4.64e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 134 RCSINRVLWTPSGRRLITGSQSGEFTLWNGQSFNFEMILQAHDQPIRSMVWSHNENYMVSGDDGGTLKYWQNNMNNVKAN 213
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 214 KTAHKESIRDLSFCKTDLKFCSCSDDTTVKVWDFTKCVDESSLTGHGWDVKSVDWHPTKSLLVSGGKDQLVKLWDTRSGR 293
Cdd:cd00200    89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 294 ELCSLHGHKNIVLSVKWNQNGNWLLTASKDQIIKLYDIRTMKELQSFRGHTKDVTSLAWHPcHEEYFVSGSSDGSICHWI 373
Cdd:cd00200   169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWD 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1063728858 374 VGHENPQIEIPnAHDNSVWDLAWHPIGYLLCSGSNDHTTKFW 415
Cdd:cd00200   248 LRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
82-415 3.63e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.78  E-value: 3.63e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858  82 VQARTWQRDSRDRTTLQPTPAAAVDMLPTVAYSDNPST-------------SFAAKFVHASLNKNRCSINRVLWTPSGRR 148
Cdd:COG2319    55 AGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLlasasadgtvrlwDLATGLLLRTLTGHTGAVRSVAFSPDGKT 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 149 LITGSQSGEFTLWNGQSFNFEMILQAHDQPIRSMVWSHNENYMVSGDDGGTLKYWQNNMNNVKANKTAHKESIRDLSFCK 228
Cdd:COG2319   135 LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 229 TDLKFCSCSDDTTVKVWDFTKCVDESSLTGHGWDVKSVDWHPTKSLLVSGGKDQLVKLWDTRSGRELCSLHGHKNIVLSV 308
Cdd:COG2319   215 DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 309 KWNQNGNWLLTASKDQIIKLYDIRTMKELQSFRGHTKDVTSLAWHPcHEEYFVSGSSDGSICHWIVgHENPQIEIPNAHD 388
Cdd:COG2319   295 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDL-ATGELLRTLTGHT 372

                         330       340
                  ....*....|....*....|....*..
gi 1063728858 389 NSVWDLAWHPIGYLLCSGSNDHTTKFW 415
Cdd:COG2319   373 GAVTSVAFSPDGRTLASGSADGTVRLW 399
PTZ00421 PTZ00421
coronin; Provisional
 230-343 1.71e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.21  E-value: 1.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 230 DLKFCSCSDDTTVKVWDF------TKCVDE-SSLTGHGWDVKSVDWHPT-KSLLVSGGKDQLVKLWDTRSGRELCSLHGH 301
Cdd:PTZ00421   88 PQKLFTASEDGTIMGWGIpeegltQNISDPiVHLQGHTKKVGIVSFHPSaMNVLASAGADMVVNVWDVERGKAVEVIKCH 167

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1063728858 302 KNIVLSVKWNQNGNWLLTASKDQIIKLYDIRTMKELQSFRGH 343
Cdd:PTZ00421  168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 333-372 2.45e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 2.45e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1063728858  333 TMKELQSFRGHTKDVTSLAWHPcHEEYFVSGSSDGSICHW 372
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
334-372 4.10e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 4.10e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1063728858 334 MKELQSFRGHTKDVTSLAWHPcHEEYFVSGSSDGSICHW 372
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 134-415 4.64e-69

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 226.83  E-value: 4.64e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 134 RCSINRVLWTPSGRRLITGSQSGEFTLWNGQSFNFEMILQAHDQPIRSMVWSHNENYMVSGDDGGTLKYWQNNMNNVKAN 213
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 214 KTAHKESIRDLSFCKTDLKFCSCSDDTTVKVWDFTKCVDESSLTGHGWDVKSVDWHPTKSLLVSGGKDQLVKLWDTRSGR 293
Cdd:cd00200    89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 294 ELCSLHGHKNIVLSVKWNQNGNWLLTASKDQIIKLYDIRTMKELQSFRGHTKDVTSLAWHPcHEEYFVSGSSDGSICHWI 373
Cdd:cd00200   169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWD 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1063728858 374 VGHENPQIEIPnAHDNSVWDLAWHPIGYLLCSGSNDHTTKFW 415
Cdd:cd00200   248 LRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
82-415 3.63e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.78  E-value: 3.63e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858  82 VQARTWQRDSRDRTTLQPTPAAAVDMLPTVAYSDNPST-------------SFAAKFVHASLNKNRCSINRVLWTPSGRR 148
Cdd:COG2319    55 AGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLlasasadgtvrlwDLATGLLLRTLTGHTGAVRSVAFSPDGKT 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 149 LITGSQSGEFTLWNGQSFNFEMILQAHDQPIRSMVWSHNENYMVSGDDGGTLKYWQNNMNNVKANKTAHKESIRDLSFCK 228
Cdd:COG2319   135 LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 229 TDLKFCSCSDDTTVKVWDFTKCVDESSLTGHGWDVKSVDWHPTKSLLVSGGKDQLVKLWDTRSGRELCSLHGHKNIVLSV 308
Cdd:COG2319   215 DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 309 KWNQNGNWLLTASKDQIIKLYDIRTMKELQSFRGHTKDVTSLAWHPcHEEYFVSGSSDGSICHWIVgHENPQIEIPNAHD 388
Cdd:COG2319   295 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDL-ATGELLRTLTGHT 372

                         330       340
                  ....*....|....*....|....*..
gi 1063728858 389 NSVWDLAWHPIGYLLCSGSNDHTTKFW 415
Cdd:COG2319   373 GAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-415 4.86e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 4.86e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 172 LQAHDQPIRSMVWSHNENYMVSGDDGGTLKYWQNNMNNVKANKTAHKESIRDLSFCKTDLKFCSCSDDTTVKVWDFTKCV 251
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 252 DESSLTGHGWDVKSVDWHPTKSLLVSGGKDQLVKLWDTRSGRELCSLHGHKNIVLSVKWNQNGNWLLTASKDQIIKLYDI 331
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 332 RTMKELQSFRGHTKDVTSLAWHPcHEEYFVSGSSDGSICHWivgheNP----QIEIPNAHDNSVWDLAWHPIGYLLCSGS 407
Cdd:cd00200   165 RTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLW-----DLstgkCLGTLRGHENGVNSVAFSPDGYLLASGS 238


                  ....*...
gi 1063728858 408 NDHTTKFW 415
Cdd:cd00200   239 EDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
137-415 1.13e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 1.13e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 137 INRVLWTPSGRRLITGSQSGEFTLWNGQSFNFEMILQAHDQPIRSMVWSHNENYMVSGDDGGTLKYWQNNMNNVKANKTA 216
Cdd:COG2319    39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 217 HKESIRDLSFCKTDLKFCSCSDDTTVKVWDFTKCVDESSLTGHGWDVKSVDWHPTKSLLVSGGKDQLVKLWDTRSGRELC 296
Cdd:COG2319   119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 297 SLHGHKNIVLSVKWNQNGNWLLTASKDQIIKLYDIRTMKELQSFRGHTKDVTSLAWHPcHEEYFVSGSSDGSICHWIVGh 376
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLA- 276

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1063728858 377 ENPQIEIPNAHDNSVWDLAWHPIGYLLCSGSNDHTTKFW 415
Cdd:COG2319   277 TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
141-415 1.75e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 169.71  E-value: 1.75e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 141 LWTPSGRRLITGSQSGEFTLWNGQSFNFEMILQAHDQPIRSMVWSHNENYMVSGDDGGTLKYWQNNMNNVKANKTAHKES 220
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 221 IRDLSFCKTDLKFCSCSDDTTVKVWDFTKCVDESSLTGHGWDVKSVDWHPTKSLLVSGGKDQLVKLWDTRSGRELCSLHG 300
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 301 HKNIVLSVKWNQNGNWLLTASKDQIIKLYDIRTMKELQSFRGHTKDVTSLAWHPcHEEYFVSGSSDGSICHW-IVGheNP 379
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWdLAT--GK 237

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1063728858 380 QIEIPNAHDNSVWDLAWHPIGYLLCSGSNDHTTKFW 415
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
136-333 2.29e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.15  E-value: 2.29e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 136 SINRVLWTPSGRRLITGSQSGEFTLWNGQSFNFEMILQAHDQPIRSMVWSHNENYMVSGDDGGTLKYWQNNMNNVKANKT 215
Cdd:COG2319   206 AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 216 AHKESIRDLSFCKTDLKFCSCSDDTTVKVWDFTKCVDESSLTGHGWDVKSVDWHPTKSLLVSGGKDQLVKLWDTRSGREL 295
Cdd:COG2319   286 GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1063728858 296 CSLHGHKNIVLSVKWNQNGNWLLTASKDQIIKLYDIRT 333
Cdd:COG2319   366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-330 4.02e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 151.33  E-value: 4.02e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 135 CSINRVLWTPSGRRLITGSQSGEFTLWNGQSFNFEMILQAHDQPIRSMVWSHNENYMVSGDDGGTLKYWQNNMNNVKANK 214
Cdd:cd00200    94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 215 TAHKESIRDLSFCKTDLKFCSCSDDTTVKVWDFT--KCVDesSLTGHGWDVKSVDWHPTKSLLVSGGKDQLVKLWDTRSG 292
Cdd:cd00200   174 TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStgKCLG--TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG 251

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1063728858 293 RELCSLHGHKNIVLSVKWNQNGNWLLTASKDQIIKLYD 330
Cdd:cd00200   252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 336-415 3.97e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.20  E-value: 3.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 336 ELQSFRGHTKDVTSLAWHPcHEEYFVSGSSDGSICHWIVGHENPQIEIPNaHDNSVWDLAWHPIGYLLCSGSNDHTTKFW 415
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLW 78
PTZ00421 PTZ00421
coronin; Provisional
 230-343 1.71e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 57.21  E-value: 1.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 230 DLKFCSCSDDTTVKVWDF------TKCVDE-SSLTGHGWDVKSVDWHPT-KSLLVSGGKDQLVKLWDTRSGRELCSLHGH 301
Cdd:PTZ00421   88 PQKLFTASEDGTIMGWGIpeegltQNISDPiVHLQGHTKKVGIVSFHPSaMNVLASAGADMVVNVWDVERGKAVEVIKCH 167

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1063728858 302 KNIVLSVKWNQNGNWLLTASKDQIIKLYDIRTMKELQSFRGH 343
Cdd:PTZ00421  168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 333-372 2.45e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 2.45e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1063728858  333 TMKELQSFRGHTKDVTSLAWHPcHEEYFVSGSSDGSICHW 372
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 204-343 2.47e-08

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 56.88  E-value: 2.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 204 QNNMNNVKANK-TAHKESIRDLSF--CKTDLkFCSCSDDTTVKVWDFTKcVDESS---------LTGHGWDVKSVDWHPT 271
Cdd:PTZ00420   59 ENQMRKPPVIKlKGHTSSILDLQFnpCFSEI-LASGSEDLTIRVWEIPH-NDESVkeikdpqciLKGHKKKISIIDWNPM 136

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063728858 272 KS-LLVSGGKDQLVKLWDTRSGRELCSLHGHKNIVlSVKWNQNGNWLLTASKDQIIKLYDIRTMKELQSFRGH 343
Cdd:PTZ00420  137 NYyIMCSSGFDSFVNIWDIENEKRAFQINMPKKLS-SLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIH 208
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 291-330 6.73e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 6.73e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1063728858  291 SGRELCSLHGHKNIVLSVKWNQNGNWLLTASKDQIIKLYD 330
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 306-415 3.24e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 53.42  E-value: 3.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 306 LSVKWNQNGNWLLTAskdqiIKLYDIRTMKELQSFRGHTKDVTSLAWHPCHEEYFVSGSSDGSICHWIVGHENPQIE--- 382
Cdd:PTZ00420   41 VAVPWEVEGGGLIGA-----IRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKeik 115

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1063728858 383 ----IPNAHDNSVWDLAWHPIGY-LLCSGSNDHTTKFW 415
Cdd:PTZ00420  116 dpqcILKGHKKKISIIDWNPMNYyIMCSSGFDSFVNIW 153
WD40 pfam00400
WD domain, G-beta repeat;
334-372 4.10e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 4.10e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1063728858 334 MKELQSFRGHTKDVTSLAWHPcHEEYFVSGSSDGSICHW 372
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
292-330 4.53e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 4.53e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1063728858 292 GRELCSLHGHKNIVLSVKWNQNGNWLLTASKDQIIKLYD 330
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 254-288 6.41e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 6.41e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1063728858  254 SSLTGHGWDVKSVDWHPTKSLLVSGGKDQLVKLWD 288
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
255-288 1.79e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.79e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1063728858 255 SLTGHGWDVKSVDWHPTKSLLVSGGKDQLVKLWD 288
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 120-204 2.72e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 120 SFAAKFVHASLNKNRCSINRVLWTPSGRRLITGSQSGEFTLWNGQSFNFEMILQAHDQPIRSMVWSHNENYMVSGDDGGT 199
Cdd:cd00200   205 DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT 284


                  ....*
gi 1063728858 200 LKYWQ 204
Cdd:cd00200   285 IRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 225-372 5.09e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 49.70  E-value: 5.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 225 SFCKTDLkfCSCSDDTTVKVWDFTKCVDESSLTGHGWDVKSVDWHPTK-SLLVSGGKDQLVKLWDTRSGRELCSLHGHKN 303
Cdd:PLN00181  542 SYIKSQV--ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN 619

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 304 IVLSVKWNQNGNWLLTASKDQIIKLYDIRTMK-ELQSFRGHTKDVTSLAWhpCHEEYFVSGSSDGSICHW 372
Cdd:PLN00181  620 ICCVQFPSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRF--VDSSTLVSSSTDNTLKLW 687
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 268-352 1.19e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.19  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 268 WHPTKSLLVSGGKDQLV--------KLWDTrsgrelcSLHGHKNIVLSVKWNQNGNWLLTASKDQIIKLYDIRTMKELQS 339
Cdd:pfam12894   3 WCPTMDLIALATEDGELllhrlnwqRVWTL-------SPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHH 75

                          90
                  ....*....|...
gi 1063728858 340 FRGHTKDVTSLAW 352
Cdd:pfam12894  76 FSAGSDLITCLGW 88
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 385-415 1.57e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.57e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1063728858  385 NAHDNSVWDLAWHPIGYLLCSGSNDHTTKFW 415
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 165-203 2.70e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.70e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1063728858  165 SFNFEMILQAHDQPIRSMVWSHNENYMVSGDDGGTLKYW 203
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 215-246 7.27e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 7.27e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1063728858  215 TAHKESIRDLSFCKTDLKFCSCSDDTTVKVWD 246
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
385-415 7.52e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 7.52e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1063728858 385 NAHDNSVWDLAWHPIGYLLCSGSNDHTTKFW 415
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
215-246 3.89e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.89e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1063728858 215 TAHKESIRDLSFCKTDLKFCSCSDDTTVKVWD 246
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
166-203 6.35e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 6.35e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1063728858 166 FNFEMILQAHDQPIRSMVWSHNENYMVSGDDGGTLKYW 203
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 298-411 7.72e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 7.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728858 298 LHGHKNIVLSVKWNQ-NGNWLLTASKDQIIKLYDI-------RTMKELQSFRGHTKDVTSLAWHPCHEEYFVSGSSDGSI 369
Cdd:PTZ00421   71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVV 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1063728858 370 CHWIVgHENPQIEIPNAHDNSVWDLAWHPIGYLLCSGSNDHT 411
Cdd:PTZ00421  151 NVWDV-ERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKK 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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