F-box only protein C-terminal region; This entry represents the C-terminal region of several F-box only proteins. These proteins are the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. This family includes yeast HRT3 protein as well as human F-box only 9 protein.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063685464 116 YKILQSKYDGSWRKMWLLRSRVRTDGLYVSRNTYIRAGIAEWKITNPVHIVCYYRYIRFYPSGRFLYKNSSQKLKDVAKY 195
Cdd:pfam19270   1 YKIVRSKYRGSWRKMFLERPRLRTDGLYVSRNTYIRAGVAEWTVTNPVHLVCYYRYLRFFPSGRFLYKTSPEKLKDVAKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063685464 196 MNFKASKSE-NLYKGTYTLsmSDDKIEAAVLYPGTRPTVLRIRLRLRGTAIGANNRMDLLSLVTSGVNDEEISStEEDIL 274
Cdd:pfam19270  81 MNFRASKADqCVFSGRYTL--TGDRVEAALLYPGSRPTELRIRLRLRSTTPGANNRLDVLSLVTSDVDEGEVSP-EEDIL 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063685464 275 GLVEGWEDDETHNPDIPAVSHKRGMTAFVFVPFEEVDESVLNLPPEKMDYYVTG 328
Cdd:pfam19270 158 PLVEGWEEDEEHDPEVPARSHRRGLNPFVFVPFEEVETSVLNLPVDKMDFYVPG 211

F-box only protein C-terminal region; This entry represents the C-terminal region of several F-box only proteins. These proteins are the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. This family includes yeast HRT3 protein as well as human F-box only 9 protein.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063685464 116 YKILQSKYDGSWRKMWLLRSRVRTDGLYVSRNTYIRAGIAEWKITNPVHIVCYYRYIRFYPSGRFLYKNSSQKLKDVAKY 195
Cdd:pfam19270   1 YKIVRSKYRGSWRKMFLERPRLRTDGLYVSRNTYIRAGVAEWTVTNPVHLVCYYRYLRFFPSGRFLYKTSPEKLKDVAKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063685464 196 MNFKASKSE-NLYKGTYTLsmSDDKIEAAVLYPGTRPTVLRIRLRLRGTAIGANNRMDLLSLVTSGVNDEEISStEEDIL 274
Cdd:pfam19270  81 MNFRASKADqCVFSGRYTL--TGDRVEAALLYPGSRPTELRIRLRLRSTTPGANNRLDVLSLVTSDVDEGEVSP-EEDIL 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063685464 275 GLVEGWEDDETHNPDIPAVSHKRGMTAFVFVPFEEVDESVLNLPPEKMDYYVTG 328
Cdd:pfam19270 158 PLVEGWEEDEEHDPEVPARSHRRGLNPFVFVPFEEVETSVLNLPVDKMDFYVPG 211

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1063685464  61 CLPDELLFEVFARMMPYDLGRASCVCRKWRYTVRNPMFWRN 101
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43

F-box only protein C-terminal region; This entry represents the C-terminal region of several F-box only proteins. These proteins are the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. This family includes yeast HRT3 protein as well as human F-box only 9 protein.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063685464 116 YKILQSKYDGSWRKMWLLRSRVRTDGLYVSRNTYIRAGIAEWKITNPVHIVCYYRYIRFYPSGRFLYKNSSQKLKDVAKY 195
Cdd:pfam19270   1 YKIVRSKYRGSWRKMFLERPRLRTDGLYVSRNTYIRAGVAEWTVTNPVHLVCYYRYLRFFPSGRFLYKTSPEKLKDVAKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063685464 196 MNFKASKSE-NLYKGTYTLsmSDDKIEAAVLYPGTRPTVLRIRLRLRGTAIGANNRMDLLSLVTSGVNDEEISStEEDIL 274
Cdd:pfam19270  81 MNFRASKADqCVFSGRYTL--TGDRVEAALLYPGSRPTELRIRLRLRSTTPGANNRLDVLSLVTSDVDEGEVSP-EEDIL 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063685464 275 GLVEGWEDDETHNPDIPAVSHKRGMTAFVFVPFEEVDESVLNLPPEKMDYYVTG 328
Cdd:pfam19270 158 PLVEGWEEDEEHDPEVPARSHRRGLNPFVFVPFEEVETSVLNLPVDKMDFYVPG 211

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1063685464  61 CLPDELLFEVFARMMPYDLGRASCVCRKWRYTVRNPMFWRN 101
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43

A Receptor for Ubiquitination Targets;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1063685464   62 LPDELLFEVFARMMPYDLGRASCVCRKWRYTVRNPMFWRN 101
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFK 40

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1063685464  61 CLPDELLFEVFARMMPYDLGRASCVCRKWRYTVRNPMFWRNAC 103
Cdd:cd22139     3 CLPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWKQIC 45

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1063685464  62 LPDELLFEVFARMMPYDLGRASCVCRKWRYTVRNPMFWRN 101
Cdd:cd22091     4 LPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKR 43

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1063685464  61 CLPDELLFEVFARMMPYDLGRASCVCRKWRYTVRNPMFWRNACLK 105
Cdd:cd22104     3 NLPSVVLVHIFSYLPPRDRLRASSTCRRWREALFHPSLWRSLRLH 47

F-box domain found in F-box only proteins FBXO6, FBXO44 and similar proteins; This subfamily includes FBXO6 and FBXO44. FBXO6, also called FBX6, F-box protein that recognizes sugar chains 2 (FBS2), or F-box/G-domain protein 2 (FBG2), is a substrate-recognition component of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. It is involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins, by recognizing and binding sugar chains on unfolded glycoproteins that are retro-translocated into the cytosol and promoting their ubiquitination and subsequent degradation. FBXO6 can recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. It also recognizes sulfated glycans. FBXO6 is involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. FBXO44, also called FBXO6A, FBX44, or F-box/G-domain protein 3 (FBG3), is a substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It interacts with SKP1 and CUL1. FBXO44 mediates BRCA1 ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1063685464  62 LPDELLFEVFARMMPYDLGRaSC--VCRKWRYTVRNPMFWRNACLK 105
Cdd:cd22168     7 LPEDVLLEILSLVPARDLIL-SCrlVCSRWRDLVDLPTLWKRKCQR 51

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1063685464  61 CLPDELLFEVFARMMPYDLGRASCVCRKWRYTVRNPMFWR 100
Cdd:cd22152     4 GLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFR 43

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|
gi 1063685464  61 CLPDELLFEVFARMMPYDLGRASCVCRKWR 90
Cdd:cd22114     3 SLPDELLLGIFSCLCLPDLLKVSQVCKRWY 32

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1063685464  62 LPDELLFEVFARMMPYD-LGRASCVCRKWRYTVRNPMFWR 100
Cdd:cd22164     5 LPDDLTASILSRLGAIDiLTNAQKVCKLWRRICKDPSMWR 44

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1063685464  62 LPDELLFEVFARMMPYDLGRASCVCRKWRYTVRNPMF 98
Cdd:cd22157     3 LPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39

F-box domain found in F-box only protein 42 (FBXO42) and similar proteins; FBXO42, also called FBX42, or just one F-box and Kelch domain-containing protein (JFK), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It specifically recognizes p53/TP53, promoting its ubiquitination and degradation. FBXO42 is also involved in the ubiquitin-proteasome system that may play a role in the pathogenesis of Parkinson's disease (PD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1063685464  62 LPDELLFEVFARMMPY-DLGRASCVCRKWRYTVRN 95
Cdd:cd22110     4 LPEEILEYILSYLSPYgDLKSAALVCKRWHRIIKG 38

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1063685464  62 LPDELLFEVFARMMPYDLGRASCVCRKWRYTVRNPMFW 99
Cdd:cd22118     4 LPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1063685464  62 LPDELLFEVFARMMPYDLGRASCVCRKWRYTVRNPMFWR 100
Cdd:cd20090     5 LPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWR 43

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1063685464  61 CLPDELLFEVFARMMPYDLGRASCVCRKWRYTVRN-PMFWRNAC 103
Cdd:cd22113     3 LLPPEMSLRIFSQLDVQSLCRASQTCKTWNDLIENsDYLWRPHC 46

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1063685464  62 LPDELLFEVFARMMPYDLGRASCVCRKWRYTVRNPMFWR 100
Cdd:cd22120     4 LPDDVILQIFSHLPTNQLCRCARVCRRWYNLAWDPRLWT 42

F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1063685464  62 LPDELLFEVFARMMPYDLGRASCVCRKWRYTVRNPMFW 99
Cdd:cd22124     4 LPRKAALKIFSYLDLRDLARCAQVCRSWKVITQSSSLW 41

F-box domain found in Arabidopsis thaliana transport inhibitor response 1 protein (TIR1), coronatine-insensitive protein 1 (COI1) and similar proteins; TIR1, also called F-box/LRR-repeat protein 1 (FBL1), is part of an SCF (SKP1-cullin-F-box) protein ligase complex that promotes the ubiquitin-dependent proteolysis of a family of transcriptional regulators known as Aux/IAAs in an auxin-dependent manner. TIR1 is an auxin receptor that plays a potential role in plant hormone signaling. COI1, also called F-box/LRR-repeat protein 2 (FBL2), is the substrate-recruiting module of an SCF ubiquitin E3 ligase complex. It mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JASMONATE ZIM-domain (JAZ) family proteins. This subfamily also includes Arabidopsis thaliana EIN3-binding F-box protein 1 (EBF1). EBF1, also called F-box/LRR-repeat protein 6 (FBL6), is a component of the SCF(EBF1) E3 ubiquitin ligase complex, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including EIN3 and EIL1). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|
gi 1063685464  61 CLPDELLFEVFARM-MPYDLGRASCVCRKW 89
Cdd:cd22159     3 LLPDEILELIFSYLsDPWDRNSCSLVCKRW 32