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Conserved domains on  [gi|1063693266|ref|NP_001321612|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
198-380 2.93e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 2.93e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 198 PSGSlRLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 276
Cdd:COG2319   172 PDGK-LLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 277 ASAWHPNGLILATGNQDTACRLWDIrNPSESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDL 356
Cdd:COG2319   251 SVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 329

                         170       180
                  ....*....|....*....|....
gi 1063693266 357 FGEIAGISFSPDTEALYVGVADRT 380
Cdd:COG2319   330 TGAVRSVAFSPDGKTLASGSDDGT 353
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
198-380 2.93e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 2.93e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 198 PSGSlRLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 276
Cdd:COG2319   172 PDGK-LLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 277 ASAWHPNGLILATGNQDTACRLWDIrNPSESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDL 356
Cdd:COG2319   251 SVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 329

                         170       180
                  ....*....|....*....|....
gi 1063693266 357 FGEIAGISFSPDTEALYVGVADRT 380
Cdd:COG2319   330 TGAVRSVAFSPDGKTLASGSDDGT 353
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 197-380 4.51e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 4.51e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 197 DPSGSLrLITANNDCKIRVFDAQSFTRVSEF--ALDWsVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDY 274
Cdd:cd00200    18 SPDGKL-LATGSGDGTIKVWDLETGELLRTLkgHTGP-VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 275 SFASAWHPNGLILATGNQDTACRLWDIRNPSESFaVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEI 354
Cdd:cd00200    96 VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG----KCV 170

                         170       180       190
                  ....*....|....*....|....*....|
gi 1063693266 355 DLF----GEIAGISFSPDTEALYVGVADRT 380
Cdd:cd00200   171 ATLtghtGEVNSVAFSPDGEKLLSSSSDGT 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 261-300 2.62e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.62e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1063693266  261 SGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWD 300
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
262-300 1.14e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.14e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1063693266 262 GKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWD 300
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 205-346 1.15e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 40.41  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 205 ITANNDCKIRVFDAQSFTRVSEFALDWSVNNTSVSPDGKLLAV-VGDSTECLISDSHSGKVISSLRGHKD-YSFAsaWHP 282
Cdd:TIGR03866  15 VSNEKDNTISVIDTATLKVTRTFPVGQRPRGITFSKDGKLLYVcASDSDTIQVIDPATGEVLHTLPSGPDpEQFA--LHP 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063693266 283 NGLILATGNQDTA-CRLWDIrnpsESFAVLKG-NMGA-IRGLKFTPEGRFLA-MAEPADFVHIFDTQS 346
Cdd:TIGR03866  93 NGKILYIANEDDAlVTVIDI----ETRKVLAQiDVGVePEGMAVSPDGKIVVnTSETTNMAHWIDTAT 156
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
198-380 2.93e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 2.93e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 198 PSGSlRLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 276
Cdd:COG2319   172 PDGK-LLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 277 ASAWHPNGLILATGNQDTACRLWDIrNPSESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDL 356
Cdd:COG2319   251 SVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 329

                         170       180
                  ....*....|....*....|....
gi 1063693266 357 FGEIAGISFSPDTEALYVGVADRT 380
Cdd:COG2319   330 TGAVRSVAFSPDGKTLASGSDDGT 353
WD40 COG2319
WD40 repeat [General function prediction only];
198-380 4.04e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 4.04e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 198 PSGSlRLITANNDCKIRVFDAQSFTRVSEFAL-DWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 276
Cdd:COG2319   214 PDGK-LLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVN 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 277 ASAWHPNGLILATGNQDTACRLWDIRNPsESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDL 356
Cdd:COG2319   293 SVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371

                         170       180
                  ....*....|....*....|....
gi 1063693266 357 FGEIAGISFSPDTEALYVGVADRT 380
Cdd:COG2319   372 TGAVTSVAFSPDGRTLASGSADGT 395
WD40 COG2319
WD40 repeat [General function prediction only];
203-380 1.57e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.92  E-value: 1.57e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 203 RLITANNDCKIRVFDAQS-FTRVSEFALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSFASAWH 281
Cdd:COG2319    92 LLASASADGTVRLWDLATgLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 282 PNGLILATGNQDTACRLWDIRNPSEsFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEIDLF---- 357
Cdd:COG2319   172 PDGKLLASGSDDGTVRLWDLATGKL-LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG----KLLRTLtghs 246

                         170       180
                  ....*....|....*....|...
gi 1063693266 358 GEIAGISFSPDTEALYVGVADRT 380
Cdd:COG2319   247 GSVRSVAFSPDGRLLASGSADGT 269
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 197-380 4.51e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 4.51e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 197 DPSGSLrLITANNDCKIRVFDAQSFTRVSEF--ALDWsVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDY 274
Cdd:cd00200    18 SPDGKL-LATGSGDGTIKVWDLETGELLRTLkgHTGP-VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 275 SFASAWHPNGLILATGNQDTACRLWDIRNPSESFaVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEI 354
Cdd:cd00200    96 VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG----KCV 170

                         170       180       190
                  ....*....|....*....|....*....|
gi 1063693266 355 DLF----GEIAGISFSPDTEALYVGVADRT 380
Cdd:cd00200   171 ATLtghtGEVNSVAFSPDGEKLLSSSSDGT 200
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 154-380 2.21e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 2.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 154 NLILLGGFDGelLCKCVNQPGVAFCTRLSTEDNAItNTVDIyrDPSGSLrLITANNDCKIRVFDAQSFTRVSEFA--LDW 231
Cdd:cd00200    64 TYLASGSSDK--TIRLWDLETGECVRTLTGHTSYV-SSVAF--SPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRghTDW 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 232 sVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDIRNPSESfAVL 311
Cdd:cd00200   138 -VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL-GTL 215

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063693266 312 KGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQeidLFG---EIAGISFSPDTEALYVGVADRT 380
Cdd:cd00200   216 RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---LSGhtnSVTSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
230-380 8.18e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 8.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 230 DWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDIRNPsESFA 309
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-KLLR 156

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063693266 310 VLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEIDLF----GEIAGISFSPDTEALYVGVADRT 380
Cdd:COG2319   157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG----KLLRTLtghtGAVRSVAFSPDGKLLASGSADGT 227
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 197-343 8.66e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 8.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 197 DPSGSLrLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYS 275
Cdd:cd00200   144 SPDGTF-VASSSQDGTIKLWDLRTGKCVATLtGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGV 222

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063693266 276 FASAWHPNGLILATGNQDTACRLWDIRNPSESfAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFD 343
Cdd:cd00200   223 NSVAFSPDGYLLASGSEDGTIRVWDLRTGECV-QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 199-380 5.11e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 5.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 199 SGSLRLITANNDCKIRVFDAQSFTRVSEFALD----WSVnntSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDY 274
Cdd:cd00200    61 ADGTYLASGSSDKTIRLWDLETGECVRTLTGHtsyvSSV---AFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 275 SFASAWHPNGLILATGNQDTACRLWDIRNPSeSFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQei 354
Cdd:cd00200   138 VNSVAFSPDGTFVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT-- 214

                         170       180
                  ....*....|....*....|....*....
gi 1063693266 355 dLFG---EIAGISFSPDTEALYVGVADRT 380
Cdd:cd00200   215 -LRGhenGVNSVAFSPDGYLLASGSEDGT 242
WD40 COG2319
WD40 repeat [General function prediction only];
198-303 2.16e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.18  E-value: 2.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 198 PSGSlRLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 276
Cdd:COG2319   298 PDGK-LLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376

                          90       100
                  ....*....|....*....|....*..
gi 1063693266 277 ASAWHPNGLILATGNQDTACRLWDIRN 303
Cdd:COG2319   377 SVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
196-380 2.19e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.10  E-value: 2.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 196 RDPSGSLRLITANNDCKIRVFDAQSFTRVSEFALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYS 275
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 276 FASAWHPNGLILATGNQDTACRLWDIRNPSEsFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEID 355
Cdd:COG2319    82 LSVAFSPDGRLLASASADGTVRLWDLATGLL-LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG----KLLR 156

                         170       180
                  ....*....|....*....|....*....
gi 1063693266 356 LF----GEIAGISFSPDTEALYVGVADRT 380
Cdd:COG2319   157 TLtghsGAVTSVAFSPDGKLLASGSDDGT 185
WD40 COG2319
WD40 repeat [General function prediction only];
237-380 3.65e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 3.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 237 SVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDIRNPSESfAVLKGNMG 316
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL-ATLLGHTA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063693266 317 AIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDLFGEIAGISFSPDTEALYVGVADRT 380
Cdd:COG2319    80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 265-380 3.81e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 3.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 265 ISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDIrNPSESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDT 344
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1063693266 345 QSGFLQSQEIDLFGEIAGISFSPDTEALYVGVADRT 380
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 261-300 2.62e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.62e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1063693266  261 SGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWD 300
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
262-300 1.14e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.14e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1063693266 262 GKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWD 300
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 239-273 1.51e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.34  E-value: 1.51e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1063693266 239 SPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKD 273
Cdd:pfam12894  47 RPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSD 81
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
179-268 5.47e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 5.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 179 TRLSTEDNAITNTVD-------IYRDPSGSLRLITANNDCKIRVFDAQSFTRVSEFALDWSVNNTSVSPDGKLLAVV--- 248
Cdd:COG3391    93 SVIDLATGKVVATIPvgggprgLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVAnsg 172

                          90       100
                  ....*....|....*....|..
gi 1063693266 249 GDSTECLIS--DSHSGKVISSL 268
Cdd:COG3391   173 SNTVSVIVSviDTATGKVVATI 194
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 205-346 1.15e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 40.41  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266 205 ITANNDCKIRVFDAQSFTRVSEFALDWSVNNTSVSPDGKLLAV-VGDSTECLISDSHSGKVISSLRGHKD-YSFAsaWHP 282
Cdd:TIGR03866  15 VSNEKDNTISVIDTATLKVTRTFPVGQRPRGITFSKDGKLLYVcASDSDTIQVIDPATGEVLHTLPSGPDpEQFA--LHP 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063693266 283 NGLILATGNQDTA-CRLWDIrnpsESFAVLKG-NMGA-IRGLKFTPEGRFLA-MAEPADFVHIFDTQS 346
Cdd:TIGR03866  93 NGKILYIANEDDAlVTVIDI----ETRKVLAQiDVGVePEGMAVSPDGKIVVnTSETTNMAHWIDTAT 156
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 212-358 3.85e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 39.64  E-value: 3.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266  212 KIRVFDAQSFTRVseFALDWSvnntsvsPDGKLLAVVGDSTECLISDSHSGK---VISSLRGHKDYSFasAWHPNGLILA 288
Cdd:COG4946    379 EPKQLTLGDLGRV--FNPVWS-------PDGKKIAFTDNRGRLWVVDLASGKvrkVDTDGYGDGISDL--AWSPDSKWLA 447

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266  289 ----TGNQDTACRLWDIRNpSESFAVLKGNMGAIRgLKFTPEGRFLAMA-----EPA----DFVHIFDTQSG----FLQS 351
Cdd:COG4946    448 yskpGPNQLSQIFLYDVET-GKTVQLTDGRYDDGS-PAFSPDGKYLYFLssrdfNPTygdlDFDLAFPRTTRiyavPLRK 525


                   ....*..
gi 1063693266  352 QEIDLFG 358
Cdd:COG4946    526 DAPSPFA 532
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 237-400 4.23e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 39.25  E-value: 4.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266  237 SVSPDGKLLAVVGDST--ECL----ISDSHSGKVISSLrGHKDYsFASAWHPNGLILATGNQDTacRLW--DIRNPSESf 308
Cdd:COG4946    349 AWSPDGKSIAYFSDASgeYELyiapADGSGEPKQLTLG-DLGRV-FNPVWSPDGKKIAFTDNRG--RLWvvDLASGKVR- 423

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693266  309 AVLKGNMGA-IRGLKFTPEGRFLAMAEPADF----VHIFDTQSGflQSQEI--DLFGEIAGIsFSPDTEALYVgVADRTY 381
Cdd:COG4946    424 KVDTDGYGDgISDLAWSPDSKWLAYSKPGPNqlsqIFLYDVETG--KTVQLtdGRYDDGSPA-FSPDGKYLYF-LSSRDF 499

                          170
                   ....*....|....*....
gi 1063693266  382 GSLLeykrrkDNHYMDSFY 400
Cdd:COG4946    500 NPTY------GDLDFDLAF 512
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 262-301 4.99e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.51  E-value: 4.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1063693266 262 GKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDI 301
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEV 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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