|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
217-820 |
6.51e-114 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 380.58 E-value: 6.51e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSKKeacKIICTQPRRISAISVSDRISWERGETIGRT 296
Cdd:COG1643 10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGG---RIGMLEPRRLAARAAAERMAEELGEPVGET 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGGRESSVVFCTNGILLRVLIG----KGVnssvpDIthIIVDEIHERDSYSDFMLMILRDLLPSN-PHLRL 371
Cdd:COG1643 87 VGYRVRFEDKVSAATRIEVVTEGILLRELQRdpelEGV-----DT--VIFDEFHERSLNADLLLALLLDLQPALrPDLKL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 372 ILMSATLDAERFSEYFGGCPVVRVPGFTYPVRTFFLDDalsvlnsdknshllsavkrdfkDEDKVSLDEAIdlawtndef 451
Cdd:COG1643 160 LVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPL----------------------PADERDLEDAV--------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 452 dclVDLVssegsheaynyqnsttgltplmvfagkgrvsdvckllsvgadctlkskegitalelaekenqfetAQIIREHA 531
Cdd:COG1643 209 ---ADAV-----------------------------------------------------------------REALAEEP 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 532 GNIqsnsqqaqdlldkymatikpeevdvglivklmkkicsdskdgaiLVFLPGWEEISKTKEkLLDDRFFAHsakFIILC 611
Cdd:COG1643 221 GDI--------------------------------------------LVFLPGEREIRRTAE-ALRGRLPPD---TEILP 252
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 612 LHSRVPAEEQKKVFNRPPRGCRKIVLATNIAESAVTIDDVVYVIDSGRMKEKSYDPYNDVSTLQSSWVSKANAKQRAGRA 691
Cdd:COG1643 253 LYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRA 332
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 692 GRCQAGICYHLYSKLRAASLPEYRVPEVMRmpVD--ELCLQVKML---DPncnvNDFlqKLMDPPVAQSIENALIILKDI 766
Cdd:COG1643 333 GRLAPGICYRLWSEEDFARRPAFTDPEILR--ADlaSLILELAAWglgDP----EDL--PFLDPPPARAIADARALLQEL 404
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 1063680967 767 GALTPEEELTELGQKFGQLPVHPRISKMIYFAILVNCLDPALILACAADEKDPF 820
Cdd:COG1643 405 GALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR 458
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
233-395 |
4.72e-83 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 268.94 E-value: 4.72e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 233 NQVVLIAGETGCGKTTQVPQYLLDHMWHsKKEACKIICTQPRRISAISVSDRISWERGETIGRTVGYKVRLQSEGGRESS 312
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLA-KGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 313 VVFCTNGILLRVLIGkgvNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLRLILMSATLDAERFSEYFGGCPV 392
Cdd:cd17917 80 IKFCTDGILLRELLS---DPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPV 156
|
...
gi 1063680967 393 VRV 395
Cdd:cd17917 157 IHI 159
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
217-878 |
1.53e-71 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 263.84 E-value: 1.53e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDhMWHSKKEAckIICTQPRRISAISVSDRISWERGETIGRT 296
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLE-LGRGVKGL--IGHTQPRRLAARTVANRIAEELETELGGC 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGGRESSVVFCTNGILL------RVLIgkgvnssvpDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLR 370
Cdd:PRK11131 150 VGYKVRFNDQVSDNTMVKLMTDGILLaeiqqdRLLM---------QYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLK 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 371 LILMSATLDAERFSEYFGGCPVVRVPGFTYPVRTFF---LDDAlsvlnsdknshllsavkrDFKDEDKVsldEAIdlawt 447
Cdd:PRK11131 221 VIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYrpiVEEA------------------DDTERDQL---QAI----- 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 448 ndeFDClVDLVSSEGSheaynyqnsttgltplmvfagkgrvsdvckllsvgadctlkskegitalelaekenqfetaqii 527
Cdd:PRK11131 275 ---FDA-VDELGREGP---------------------------------------------------------------- 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 528 rehagniqsnsqqaqdlldkymatikpeevdvglivklmkkicsdskdGAILVFLPGWEEISKTKEKlLDDRFFAHSAkf 607
Cdd:PRK11131 287 ------------------------------------------------GDILIFMSGEREIRDTADA-LNKLNLRHTE-- 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 608 iILCLHSRVPAEEQKKVFNrpPRGCRKIVLATNIAESAVTIDDVVYVIDSGRMKEKSYDPYNDVSTLQSSWVSKANAKQR 687
Cdd:PRK11131 316 -ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQR 392
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 688 AGRAGRCQAGICYHLYSKLRAASLPEYRVPEVMRMPVDELCLQVKMLDPNcNVNDFlqKLMDPPVAQSIENALIILKDIG 767
Cdd:PRK11131 393 KGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLG-DIAAF--PFVEAPDKRNIQDGVRLLEELG 469
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 768 ALTPEE-----ELTELGQKFGQLPVHPRISKMIYFAILVNCLDPALILACAADEKDPFTMPLspgDRKKAAAAKHElaSL 842
Cdd:PRK11131 470 AITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPM---DKQQASDEKHR--RF 544
|
650 660 670
....*....|....*....|....*....|....*....
gi 1063680967 843 YGDHSDHLATVAAF---QCWKNAKASGQAKEFCSKYFIS 878
Cdd:PRK11131 545 ADKESDFLAFVNLWnylQEQQKALSSNQFRRLCRTDYLN 583
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
217-813 |
4.58e-65 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 238.13 E-value: 4.58e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVE-SNQVVLIAgETGCGKTTQVPQYLLDHmwhsKKEACKIICTQPRRISAISVSDRISWERGETIGR 295
Cdd:TIGR01970 1 LPIHAVLPALRDALAaHPQVVLEA-PPGAGKSTAVPLALLDA----PGIGGKIIMLEPRRLAARSAAQRLASQLGEAVGQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 296 TVGYKVRLQSEGGRESSVVFCTNGILLRVLIGkgvNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPS-NPHLRLILM 374
Cdd:TIGR01970 76 TVGYRVRGENKVSRRTRLEVVTEGILTRMIQD---DPELDGVGALIFDEFHERSLDADLGLALALDVQSSlREDLKILAM 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 375 SATLDAERFSEYFGGCPVVRVPGFTYPVRTFFLddalsvlnsdknshllsAVKRDFKDEDKVSldeaidlawtndefDCL 454
Cdd:TIGR01970 153 SATLDGERLSSLLPDAPVVESEGRSFPVEIRYL-----------------PLRGDQRLEDAVS--------------RAV 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 455 VDLVSSEGsheaynyqnsttgltplmvfagkgrvsdvckllsvgadctlkskegitalelaekenqfetaqiirehagni 534
Cdd:TIGR01970 202 EHALASET------------------------------------------------------------------------ 209
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 535 qsnsqqaqdlldkymatikpeevdvglivklmkkicsdskdGAILVFLPGWEEISKTKEKLLDdrffAHSAKFIILCLHS 614
Cdd:TIGR01970 210 -----------------------------------------GSILVFLPGQAEIRRVQEQLAE----RLDSDVLICPLYG 244
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 615 RVPAEEQKKVFNRPPRGCRKIVLATNIAESAVTIDDVVYVIDSGRMKEKSYDPYNDVSTLQSSWVSKANAKQRAGRAGRC 694
Cdd:TIGR01970 245 ELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGRL 324
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 695 QAGICYHLYSKLRAASLPEYRVPEVMRMPVDELCLQVKMLdpncNVNDFLQ-KLMDPPVAQSIENALIILKDIGALTPEE 773
Cdd:TIGR01970 325 EPGVCYRLWSEEQHQRLPAQDEPEILQADLSGLALELAQW----GAKDPSDlRWLDAPPSVALAAARQLLQRLGALDAQG 400
|
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 1063680967 774 ELTELGQKFGQLPVHPRISKMiyfaiLVNCLDPALI-LACA 813
Cdd:TIGR01970 401 RLTAHGKAMAALGCHPRLAAM-----LLSAHSTGLAaLACD 436
|
|
| R3H_DEXH_helicase |
cd06007 |
R3H domain of a group of proteins which also contain a DEXH-box helicase domain, and may ... |
18-76 |
5.13e-26 |
|
R3H domain of a group of proteins which also contain a DEXH-box helicase domain, and may function as ATP-dependent DNA or RNA helicases. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Pssm-ID: 100077 Cd Length: 59 Bit Score: 102.01 E-value: 5.13e-26
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1063680967 18 GAWATKVLEDFRASGNDSYVFEQQLTNSERGIIHQMCRTMGLRSKSNGSGEERRLSLFK 76
Cdd:cd06007 1 RIAINKALEDFRASDNEEYEFPSSLTNHERAVIHRLCRKLGLKSKSKGKGSNRRLSVYK 59
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
223-401 |
5.39e-26 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 107.19 E-value: 5.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 223 RDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMwhSKKEACKIICTQPRRISAISVSDRISWERGETIGRTVGY--- 299
Cdd:smart00487 14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEAL--KRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLygg 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 300 ---KVRLQSEGGRESSVVFCTNGILLRVLIGKGVNSSvpDITHIIVDEIHERD--SYSDFMLMILRDLlpsNPHLRLILM 374
Cdd:smart00487 92 dskREQLRKLESGKTDILVTTPGRLLDLLENDKLSLS--NVDLVILDEAHRLLdgGFGDQLEKLLKLL---PKNVQLLLL 166
|
170 180
....*....|....*....|....*....
gi 1063680967 375 SATL--DAERFSEYFGGCPVVRVPGFTYP 401
Cdd:smart00487 167 SATPpeEIENLLELFLNDPVFIDVGFTPL 195
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
759-851 |
4.54e-24 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 98.08 E-value: 4.54e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 759 ALIILKDIGALTPEEELTELGQKFGQLPVHPRISKMIYFAILVNCLDPALILACAADEKDPFTMPLSPGDRKKAAAAK-- 836
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAARrr 80
|
90 100
....*....|....*....|...
gi 1063680967 837 --------HELASLYGDHSDHLA 851
Cdd:pfam04408 81 rraadekaRAKFARLDLEGDHLT 103
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
919-1007 |
3.07e-10 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 58.03 E-value: 3.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 919 LRAVIAVGLYPMLGRMCPLSKNRTRSVIetiaGAKVRVPSLSNNVdmSSTKFDEALIVFDEITRGDWgVVIRSCTVLPTI 998
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGYTTLSD----NQRVFIHPSSVLF--NEKTFPPEWVVYQELVETTK-VYIRTVTAISPE 73
|
....*....
gi 1063680967 999 PVLLFSREI 1007
Cdd:pfam07717 74 WLLLFAPHI 82
|
|
| R3H |
smart00393 |
Putative single-stranded nucleic acids-binding domain; |
25-76 |
2.24e-08 |
|
Putative single-stranded nucleic acids-binding domain;
Pssm-ID: 214647 Cd Length: 79 Bit Score: 52.69 E-value: 2.24e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1063680967 25 LEDFRASGNDSYVFEQqLTNSERGIIHQMCRTMGLRSKSNGSGEERRLSLFK 76
Cdd:smart00393 28 IARFVKSTKESVELPP-MNSYERKIVHELAEKYGLESESFGEGPKRRVVISK 78
|
|
| R3H |
pfam01424 |
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ... |
23-76 |
2.32e-07 |
|
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.
Pssm-ID: 460206 Cd Length: 60 Bit Score: 49.03 E-value: 2.32e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1063680967 23 KVLEDFRASGNDSYVFEQqLTNSERGIIHQMCRTMGLRSKSNGSGEERRLSLFK 76
Cdd:pfam01424 8 EKLAEFVKDTGKSLELPP-MSSYERRIIHELAQKYGLESESEGEEPNRRVVVYK 60
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
468-575 |
2.24e-06 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 51.11 E-value: 2.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 468 NYQNSTtGLTPLMVFAGKGRVSDVCKLLSVGADCTLKSKEGITALELAEKENQFETAQIIREHAGNIQSNSQQAQDLLDK 547
Cdd:COG0666 180 NARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258
|
90 100
....*....|....*....|....*...
gi 1063680967 548 YMATIKPEEVDVGLIVKLMKKICSDSKD 575
Cdd:COG0666 259 AAAAGAALIVKLLLLALLLLAAALLDLL 286
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
475-515 |
1.59e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 40.79 E-value: 1.59e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1063680967 475 GLTPLMVFAGKGRVSDVCKLLSVGADCTLKSKEGITALELA 515
Cdd:pfam13857 16 GYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
475-530 |
3.59e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 45.27 E-value: 3.59e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1063680967 475 GLTPLMVFAGKGRVSDVCKLLSVGADCTLKSKEGITALELAEKENQFETAQIIREH 530
Cdd:PTZ00322 115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
217-820 |
6.51e-114 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 380.58 E-value: 6.51e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSKKeacKIICTQPRRISAISVSDRISWERGETIGRT 296
Cdd:COG1643 10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGG---RIGMLEPRRLAARAAAERMAEELGEPVGET 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGGRESSVVFCTNGILLRVLIG----KGVnssvpDIthIIVDEIHERDSYSDFMLMILRDLLPSN-PHLRL 371
Cdd:COG1643 87 VGYRVRFEDKVSAATRIEVVTEGILLRELQRdpelEGV-----DT--VIFDEFHERSLNADLLLALLLDLQPALrPDLKL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 372 ILMSATLDAERFSEYFGGCPVVRVPGFTYPVRTFFLDDalsvlnsdknshllsavkrdfkDEDKVSLDEAIdlawtndef 451
Cdd:COG1643 160 LVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPL----------------------PADERDLEDAV--------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 452 dclVDLVssegsheaynyqnsttgltplmvfagkgrvsdvckllsvgadctlkskegitalelaekenqfetAQIIREHA 531
Cdd:COG1643 209 ---ADAV-----------------------------------------------------------------REALAEEP 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 532 GNIqsnsqqaqdlldkymatikpeevdvglivklmkkicsdskdgaiLVFLPGWEEISKTKEkLLDDRFFAHsakFIILC 611
Cdd:COG1643 221 GDI--------------------------------------------LVFLPGEREIRRTAE-ALRGRLPPD---TEILP 252
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 612 LHSRVPAEEQKKVFNRPPRGCRKIVLATNIAESAVTIDDVVYVIDSGRMKEKSYDPYNDVSTLQSSWVSKANAKQRAGRA 691
Cdd:COG1643 253 LYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRA 332
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 692 GRCQAGICYHLYSKLRAASLPEYRVPEVMRmpVD--ELCLQVKML---DPncnvNDFlqKLMDPPVAQSIENALIILKDI 766
Cdd:COG1643 333 GRLAPGICYRLWSEEDFARRPAFTDPEILR--ADlaSLILELAAWglgDP----EDL--PFLDPPPARAIADARALLQEL 404
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 1063680967 767 GALTPEEELTELGQKFGQLPVHPRISKMIYFAILVNCLDPALILACAADEKDPF 820
Cdd:COG1643 405 GALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR 458
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
233-395 |
4.72e-83 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 268.94 E-value: 4.72e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 233 NQVVLIAGETGCGKTTQVPQYLLDHMWHsKKEACKIICTQPRRISAISVSDRISWERGETIGRTVGYKVRLQSEGGRESS 312
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLA-KGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 313 VVFCTNGILLRVLIGkgvNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLRLILMSATLDAERFSEYFGGCPV 392
Cdd:cd17917 80 IKFCTDGILLRELLS---DPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPV 156
|
...
gi 1063680967 393 VRV 395
Cdd:cd17917 157 IHI 159
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
549-703 |
8.23e-77 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 251.68 E-value: 8.23e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 549 MATIKPEEVDVGLIVKLMKKICSDSKDGAILVFLPGWEEISKTKEKLLDDRFFAHSAKFIILCLHSRVPAEEQKKVFNRP 628
Cdd:cd18791 17 ISSEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPDLGKLLVLPLHSSLPPEEQQRVFEPP 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063680967 629 PRGCRKIVLATNIAESAVTIDDVVYVIDSGRMKEKSYDPYNDVSTLQSSWVSKANAKQRAGRAGRCQAGICYHLY 703
Cdd:cd18791 97 PPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
217-878 |
1.53e-71 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 263.84 E-value: 1.53e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDhMWHSKKEAckIICTQPRRISAISVSDRISWERGETIGRT 296
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLE-LGRGVKGL--IGHTQPRRLAARTVANRIAEELETELGGC 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGGRESSVVFCTNGILL------RVLIgkgvnssvpDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLR 370
Cdd:PRK11131 150 VGYKVRFNDQVSDNTMVKLMTDGILLaeiqqdRLLM---------QYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLK 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 371 LILMSATLDAERFSEYFGGCPVVRVPGFTYPVRTFF---LDDAlsvlnsdknshllsavkrDFKDEDKVsldEAIdlawt 447
Cdd:PRK11131 221 VIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYrpiVEEA------------------DDTERDQL---QAI----- 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 448 ndeFDClVDLVSSEGSheaynyqnsttgltplmvfagkgrvsdvckllsvgadctlkskegitalelaekenqfetaqii 527
Cdd:PRK11131 275 ---FDA-VDELGREGP---------------------------------------------------------------- 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 528 rehagniqsnsqqaqdlldkymatikpeevdvglivklmkkicsdskdGAILVFLPGWEEISKTKEKlLDDRFFAHSAkf 607
Cdd:PRK11131 287 ------------------------------------------------GDILIFMSGEREIRDTADA-LNKLNLRHTE-- 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 608 iILCLHSRVPAEEQKKVFNrpPRGCRKIVLATNIAESAVTIDDVVYVIDSGRMKEKSYDPYNDVSTLQSSWVSKANAKQR 687
Cdd:PRK11131 316 -ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQR 392
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 688 AGRAGRCQAGICYHLYSKLRAASLPEYRVPEVMRMPVDELCLQVKMLDPNcNVNDFlqKLMDPPVAQSIENALIILKDIG 767
Cdd:PRK11131 393 KGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLG-DIAAF--PFVEAPDKRNIQDGVRLLEELG 469
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 768 ALTPEE-----ELTELGQKFGQLPVHPRISKMIYFAILVNCLDPALILACAADEKDPFTMPLspgDRKKAAAAKHElaSL 842
Cdd:PRK11131 470 AITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPM---DKQQASDEKHR--RF 544
|
650 660 670
....*....|....*....|....*....|....*....
gi 1063680967 843 YGDHSDHLATVAAF---QCWKNAKASGQAKEFCSKYFIS 878
Cdd:PRK11131 545 ADKESDFLAFVNLWnylQEQQKALSSNQFRRLCRTDYLN 583
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
180-395 |
1.83e-70 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 236.27 E-value: 1.83e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 180 FKKPHMTKHDIENnvvSLSSRLKKERHFREIFEARSKLPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMW 259
Cdd:cd17972 25 FATPEQISMDLKN---ELMYQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 260 HSKKEA-CKIICTQPRRISAISVSDRISWERGETIGRTVGYKVRLQSEGGR-ESSVVFCTNGILLRVLigkgvNSSVPDI 337
Cdd:cd17972 102 QNDRAAeCNIVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRpHASILFCTVGVLLRKL-----EAGIRGI 176
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1063680967 338 THIIVDEIHERDSYSDFMLMILRDLLPSNPHLRLILMSATLDAERFSEYFGGCPVVRV 395
Cdd:cd17972 177 SHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
217-395 |
2.35e-68 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 227.79 E-value: 2.35e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMwHSKKEACKIICTQPRRISAISVSDRISWERGETIGRT 296
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDC-YANGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGGRESSVVFCTNGILLRVLIGKgvNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLRLILMSA 376
Cdd:cd17987 80 VGYQIRLESRVSPKTLLTFCTNGVLLRTLMAG--DSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSA 157
|
170
....*....|....*....
gi 1063680967 377 TLDAERFSEYFGGCPVVRV 395
Cdd:cd17987 158 ALDVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
217-395 |
9.09e-68 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 226.21 E-value: 9.09e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSKKEA-CKIICTQPRRISAISVSDRISWERGETIGR 295
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGArCNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 296 TVGYKVRLQSE-GGRESSVVFCTNGILLRVLIGkgvNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLRLILM 374
Cdd:cd17976 81 NVGYQVRLESRpPPRGGALLFCTVGVLLKKLQS---NPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLM 157
|
170 180
....*....|....*....|.
gi 1063680967 375 SATLDAERFSEYFGGCPVVRV 395
Cdd:cd17976 158 SATGDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
217-395 |
6.51e-66 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 220.87 E-value: 6.51e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLD-HMWHSKKEACKIICTQPRRISAISVSDRISWERGET--I 293
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDdAIERGKGSSCRIVCTQPRRISAISVAERVAAERAEScgL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 294 GRTVGYKVRLQSEGGRE-SSVVFCTNGILLRVLIGkgvNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLRLI 372
Cdd:cd17981 81 GNSTGYQIRLESRKPRKqGSILYCTTGIVLQWLQS---DPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVI 157
|
170 180
....*....|....*....|...
gi 1063680967 373 LMSATLDAERFSEYFGGCPVVRV 395
Cdd:cd17981 158 LMSATLNAEKFSDYFNNCPMIHI 180
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
217-813 |
4.58e-65 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 238.13 E-value: 4.58e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVE-SNQVVLIAgETGCGKTTQVPQYLLDHmwhsKKEACKIICTQPRRISAISVSDRISWERGETIGR 295
Cdd:TIGR01970 1 LPIHAVLPALRDALAaHPQVVLEA-PPGAGKSTAVPLALLDA----PGIGGKIIMLEPRRLAARSAAQRLASQLGEAVGQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 296 TVGYKVRLQSEGGRESSVVFCTNGILLRVLIGkgvNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPS-NPHLRLILM 374
Cdd:TIGR01970 76 TVGYRVRGENKVSRRTRLEVVTEGILTRMIQD---DPELDGVGALIFDEFHERSLDADLGLALALDVQSSlREDLKILAM 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 375 SATLDAERFSEYFGGCPVVRVPGFTYPVRTFFLddalsvlnsdknshllsAVKRDFKDEDKVSldeaidlawtndefDCL 454
Cdd:TIGR01970 153 SATLDGERLSSLLPDAPVVESEGRSFPVEIRYL-----------------PLRGDQRLEDAVS--------------RAV 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 455 VDLVSSEGsheaynyqnsttgltplmvfagkgrvsdvckllsvgadctlkskegitalelaekenqfetaqiirehagni 534
Cdd:TIGR01970 202 EHALASET------------------------------------------------------------------------ 209
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 535 qsnsqqaqdlldkymatikpeevdvglivklmkkicsdskdGAILVFLPGWEEISKTKEKLLDdrffAHSAKFIILCLHS 614
Cdd:TIGR01970 210 -----------------------------------------GSILVFLPGQAEIRRVQEQLAE----RLDSDVLICPLYG 244
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 615 RVPAEEQKKVFNRPPRGCRKIVLATNIAESAVTIDDVVYVIDSGRMKEKSYDPYNDVSTLQSSWVSKANAKQRAGRAGRC 694
Cdd:TIGR01970 245 ELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGRL 324
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 695 QAGICYHLYSKLRAASLPEYRVPEVMRMPVDELCLQVKMLdpncNVNDFLQ-KLMDPPVAQSIENALIILKDIGALTPEE 773
Cdd:TIGR01970 325 EPGVCYRLWSEEQHQRLPAQDEPEILQADLSGLALELAQW----GAKDPSDlRWLDAPPSVALAAARQLLQRLGALDAQG 400
|
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 1063680967 774 ELTELGQKFGQLPVHPRISKMiyfaiLVNCLDPALI-LACA 813
Cdd:TIGR01970 401 RLTAHGKAMAALGCHPRLAAM-----LLSAHSTGLAaLACD 436
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
217-395 |
7.91e-63 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 212.01 E-value: 7.91e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSKKEA-CKIICTQPRRISAISVSDRISWERGETIGR 295
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPvANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 296 TVGYKVRLQSEGGRESSVVFCTNGILLRVLIGkgvNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLRLILMS 375
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEG---DPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMS 157
|
170 180
....*....|....*....|
gi 1063680967 376 ATLDAERFSEYFGGCPVVRV 395
Cdd:cd17985 158 ATLNAELFSDYFNSCPVIHI 177
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
217-399 |
9.66e-58 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 197.34 E-value: 9.66e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSKKEaCKIICTQPRRISAISVSDRISWERGETIGRT 296
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKY-CNIVVTQPRRIAAISIARRVSQEREWTLGSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGGRESSVVFCTNGILLRVLIGkgvNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNP-HLRLILMS 375
Cdd:cd17988 80 VGYQVGLERPASEETRLIYCTTGVLLQKLIN---NKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSrHVKIILMS 156
|
170 180
....*....|....*....|....
gi 1063680967 376 ATLDAERFSEYFgGCPVVRVPGFT 399
Cdd:cd17988 157 ATISCKEFADYF-TTPNNPAYVFE 179
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
217-395 |
2.13e-55 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 190.35 E-value: 2.13e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSkkeackIICTQPRRISAISVSDRISWERGETIGRT 296
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH------IACTQPRRIACISLAKRVAFESLNQYGSK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGGRESSVVFCTNGILLRVLigkGVNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLRLILMSA 376
Cdd:cd17979 75 VAYQIRFERTRTLATKLLFLTEGLLLRQI---QRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSA 151
|
170
....*....|....*....
gi 1063680967 377 TLDAERFSEYFGGCPVVRV 395
Cdd:cd17979 152 TINIELFSGYFEGAPVVQV 170
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
217-395 |
7.70e-55 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 189.36 E-value: 7.70e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSKKEA--CKIICTQPRRISAISVSDRISWERGETIG 294
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGTAqkCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 295 -----RTVGYKVRLQSEGGRESSVVFCTNGILLRVLIGKGVNSSvpdITHIIVDEIHERDSYSDFMLMILRDLLPSNPHL 369
Cdd:cd17975 81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSS---ISHIIVDEVHERSVQSDFLLIILKEILHKRSDL 157
|
170 180
....*....|....*....|....*.
gi 1063680967 370 RLILMSATLDAERFSEYFGGCPVVRV 395
Cdd:cd17975 158 HLILMSATVDCEKFSSYFTHCPILRI 183
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
215-798 |
6.43e-51 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 194.76 E-value: 6.43e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 215 SKLPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLdhmwHSKKEACKIICTQPRRISAISVSDRISWERGETIG 294
Cdd:PRK11664 2 SSLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLL----QHGGINGKIIMLEPRRLAARNVAQRLAEQLGEKPG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 295 RTVGYKVRLQSEGGRESSVVFCTNGILLRVLigkgvnSSVPDITHI---IVDEIHERDSYSDFMLMI-------LRDllp 364
Cdd:PRK11664 78 ETVGYRMRAESKVGPNTRLEVVTEGILTRMI------QRDPELSGVglvILDEFHERSLQADLALALlldvqqgLRD--- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 365 snpHLRLILMSATLDAERFSEYFGGCPVVRVPGFTYPVrtfflddalsvlnsdknshllsavkrdfkdedkvsldeaidl 444
Cdd:PRK11664 149 ---DLKLLIMSATLDNDRLQQLLPDAPVIVSEGRSFPV------------------------------------------ 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 445 awtndefdclvdlvssegsheAYNYQnsttgltPLmvfagkgrvsdvckllsvgadctlkskegitalelaekenqfeta 524
Cdd:PRK11664 184 ---------------------ERRYQ-------PL--------------------------------------------- 190
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 525 qiirehagniqsnsqQAQDLLDKYMATikpeevdvgLIVKLMKKicsdsKDGAILVFLPGWEEISKTKEkLLDDRFfahs 604
Cdd:PRK11664 191 ---------------PAHQRFDEAVAR---------ATAELLRQ-----ESGSLLLFLPGVGEIQRVQE-QLASRV---- 236
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 605 AKFIILC-LHSRVPAEEQKKVFNRPPRGCRKIVLATNIAESAVTIDDVVYVIDSGRMKEKSYDPYNDVSTLQSSWVSKAN 683
Cdd:PRK11664 237 ASDVLLCpLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQAS 316
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 684 AKQRAGRAGRCQAGICYHLYSKLRAASLPEYRVPEVMRmpvDELC-LQVKMLDPNCnvNDFLQ-KLMDPPVAQSIENALI 761
Cdd:PRK11664 317 MTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILH---SDLSgLLLELLQWGC--HDPAQlSWLDQPPAAALAAAKR 391
|
570 580 590
....*....|....*....|....*....|....*..
gi 1063680967 762 ILKDIGALTPEEELTELGQKFGQLPVHPRISKMIYFA 798
Cdd:PRK11664 392 LLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAA 428
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
217-395 |
1.58e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 173.69 E-value: 1.58e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSKKeacKIICTQPRRISAISVSDRISWERGETIGRT 296
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGG---MIGITQPRRVAAVSVAKRVAEEMGVELGQL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGGRESSVVFCTNGILLRVLIGkgvNSSVPDITHIIVDEIHERDSYSDFMLMILRD-----LLPSNPHLRL 371
Cdd:cd17978 78 VGYSVRFDDVTSEETRIKYMTDGMLLREAIG---DPLLSKYSVIILDEAHERTVHTDVLFGLVKSaqrrrKEQKLSPLKV 154
|
170 180
....*....|....*....|....
gi 1063680967 372 ILMSATLDAERFSEYFGGCPVVRV 395
Cdd:cd17978 155 IIMSATLDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
212-396 |
2.14e-46 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 164.96 E-value: 2.14e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 212 EARSKLPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSKKeacKIICTQPRRISAISVSDRISWERGE 291
Cdd:cd17971 1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRG---KIGCTQPRRVAAMSVAKRVAEEFGC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 292 TIGRTVGYKVRLQSEGGRESSVVFCTNGILLRVLIgkgVNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLRL 371
Cdd:cd17971 78 CLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECL---IDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKL 154
|
170 180
....*....|....*....|....*
gi 1063680967 372 ILMSATLDAERFSEYFGGCPVVRVP 396
Cdd:cd17971 155 IVTSATLDAVKFSQYFYEAPIFTIP 179
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
217-395 |
2.27e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 161.90 E-value: 2.27e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWhsKKEACKIICTQPRRISAISVSDRISWERGETIGRT 296
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGY--TKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLGNE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGGRESSVVFCTNGILLRVLIGKgvnssvPDITH---IIVDEIHERDSYSDFMLMILRDLLPSNPHLRLIL 373
Cdd:cd17974 79 VGYSIRFEDCTSEKTVLKYMTDGMLLREFLTE------PDLASysvMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLI 152
|
170 180
....*....|....*....|..
gi 1063680967 374 MSATLDAERFSEYFGGCPVVRV 395
Cdd:cd17974 153 SSATMDAEKFSAFFDDAPIFRI 174
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
217-395 |
4.31e-45 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 160.70 E-value: 4.31e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHmwhSKKEACKIICTQPRRISAISVSDRISWERGETIGRT 296
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLEL---GRGIRGLIGHTQPRRLAARSVAERIAEELKTELGGA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGGRESSVVFCTNGILLRVLigkGVNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLRLILMSA 376
Cdd:cd17989 78 VGYKVRFTDQTSDETCVKLMTDGILLAET---QTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSA 154
|
170
....*....|....*....
gi 1063680967 377 TLDAERFSEYFGGCPVVRV 395
Cdd:cd17989 155 TIDAERFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
204-395 |
7.01e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 160.66 E-value: 7.01e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 204 ERHFrEIFEARSKLPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWhSKKEACKIICTQPRRISAISVSD 283
Cdd:cd17973 1 QRYF-EILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDEL-PHQPKKLVACTQPRRVAAMSVAQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 284 RISWERGETIGRTVGYKVRLQSEGGRESSVVFCTNGILLRVLIgkgvnsSVPDITH---IIVDEIHERDSYSDFMLMILR 360
Cdd:cd17973 79 RVAEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAM------SDPLLSRysvIILDEAHERTLATDILMGLLK 152
|
170 180 190
....*....|....*....|....*....|....*
gi 1063680967 361 DLLPSNPHLRLILMSATLDAERFSEYFGGCPVVRV 395
Cdd:cd17973 153 EVVRRRPDLKLIVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
217-395 |
2.58e-44 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 158.65 E-value: 2.58e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVES-NQVVLIAgETGCGKTTQVPQYLLDHMWhskKEACKIICTQPRRISAISVSDRISWERGETIGR 295
Cdd:cd17990 1 LPIAAVLPALRAALDAgGQVVLEA-PPGAGKTTRVPLALLAELW---IAGGKIIVLEPRRVAARAAARRLATLLGEAPGE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 296 TVGYKVRLQSEGGRESSVVFCTNGILLRVLIGkgvNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPS-NPHLRLILM 374
Cdd:cd17990 77 TVGYRVRGESRVGRRTRVEVVTEGVLLRRLQR---DPELSGVGAVILDEFHERSLDADLALALLLEVQQLlRDDLRLLAM 153
|
170 180
....*....|....*....|.
gi 1063680967 375 SATLDAERFSEYFGGCPVVRV 395
Cdd:cd17990 154 SATLDGDGLAALLPEAPVVES 174
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
217-387 |
5.98e-44 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 158.02 E-value: 5.98e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSKKEAckIICTQPRRISAISVSDRISWERGETIGRT 296
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGRV--VGCTQPRRVAAVTVAGRVAEEMGAVLGHE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGGR-ESSVVFCTNGILLRVLIgkgvnsSVPDITH---IIVDEIHERDSYSDFMLMILRDLLPSNPHLRLI 372
Cdd:cd17980 79 VGYCIRFDDCTDPqATRIKFLTDGMLVREMM------LDPLLTKysvIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLI 152
|
170
....*....|....*
gi 1063680967 373 LMSATLDAERFSEYF 387
Cdd:cd17980 153 VASATLDAEKFRDFF 167
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
217-392 |
1.20e-41 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 151.08 E-value: 1.20e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSKKeacKIICTQPRRISAISVSDRISWERGETIGRT 296
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDYG---MIGCTQPRRVAAMSVAKRVSEEMGVELGEE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGGRESSVVFCTNGILLRVLIGkgvNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNPHLRLILMSA 376
Cdd:cd17983 78 VGYAIRFEDCTSENTVIKYMTDGILLRESLR---DPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSA 154
|
170
....*....|....*.
gi 1063680967 377 TLDAERFSEYFGGCPV 392
Cdd:cd17983 155 TMDADKFADFFGNVPI 170
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
217-395 |
3.07e-37 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 138.45 E-value: 3.07e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWhskKEACKIICTQPRRISAISVSDRISWERGETIGRT 296
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGF---SQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGGRESSVVFCTNGILLRVLIGKgvnssvPDITH---IIVDEIHERDSYSDFMLMILRDLLPSNP-----H 368
Cdd:cd17984 78 VGYQVRFDDCSSKETAIKYMTDGCLLRHILAD------PNLTKysvIILDEAHERSLTTDILFGLLKKLFQEKSpnrkeH 151
|
170 180
....*....|....*....|....*..
gi 1063680967 369 LRLILMSATLDAERFSEYFGGCPVVRV 395
Cdd:cd17984 152 LKVVVMSATLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
217-385 |
1.03e-35 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 134.79 E-value: 1.03e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSKK--EACKIICTQPRRISAISVSDRISWERGeTIG 294
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPEsdNPGMIGITQPRRVAAVSMAKRVAEELN-VFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 295 RTVGYKVRLQSEGGRESSVVFCTNGILLR-----VLIGKgvnSSVpdithIIVDEIHERDSYSDFML------MILRDLL 363
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKeiqtdFLLRK---YSV-----IIIDEAHERSVNTDILIgmlsriVPLRAKL 151
|
170 180
....*....|....*....|....*.
gi 1063680967 364 PSNPH----LRLILMSATLDAERFSE 385
Cdd:cd17982 152 YLQDQtvkpLKLVIMSATLRVEDFTE 177
|
|
| R3H_DEXH_helicase |
cd06007 |
R3H domain of a group of proteins which also contain a DEXH-box helicase domain, and may ... |
18-76 |
5.13e-26 |
|
R3H domain of a group of proteins which also contain a DEXH-box helicase domain, and may function as ATP-dependent DNA or RNA helicases. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Pssm-ID: 100077 Cd Length: 59 Bit Score: 102.01 E-value: 5.13e-26
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1063680967 18 GAWATKVLEDFRASGNDSYVFEQQLTNSERGIIHQMCRTMGLRSKSNGSGEERRLSLFK 76
Cdd:cd06007 1 RIAINKALEDFRASDNEEYEFPSSLTNHERAVIHRLCRKLGLKSKSKGKGSNRRLSVYK 59
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
223-401 |
5.39e-26 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 107.19 E-value: 5.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 223 RDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMwhSKKEACKIICTQPRRISAISVSDRISWERGETIGRTVGY--- 299
Cdd:smart00487 14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEAL--KRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLygg 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 300 ---KVRLQSEGGRESSVVFCTNGILLRVLIGKGVNSSvpDITHIIVDEIHERD--SYSDFMLMILRDLlpsNPHLRLILM 374
Cdd:smart00487 92 dskREQLRKLESGKTDILVTTPGRLLDLLENDKLSLS--NVDLVILDEAHRLLdgGFGDQLEKLLKLL---PKNVQLLLL 166
|
170 180
....*....|....*....|....*....
gi 1063680967 375 SATL--DAERFSEYFGGCPVVRVPGFTYP 401
Cdd:smart00487 167 SATPpeEIENLLELFLNDPVFIDVGFTPL 195
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
217-395 |
1.98e-24 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 101.83 E-value: 1.98e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQVVLIAGETGCGKTTQVPQYLLDHMWHSKKEACKIICTQPRRISAISVSDRISWERGETIGRT 296
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGGRESSVVFCTNGILLRVLIgkgvnsSVPDITH---IIVDEIHERDSYSDFMLMILRDLLPSNPHLRLIL 373
Cdd:cd17977 81 VGYVIPFENCCTNETILRYCTDDMLLREMM------SDPLLESygvIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVI 154
|
170 180
....*....|....*....|..
gi 1063680967 374 MSATLDAERFSEYFGGCPVVRV 395
Cdd:cd17977 155 ITCPHLSSKLLSYYGNVPLIEV 176
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
759-851 |
4.54e-24 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 98.08 E-value: 4.54e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 759 ALIILKDIGALTPEEELTELGQKFGQLPVHPRISKMIYFAILVNCLDPALILACAADEKDPFTMPLSPGDRKKAAAAK-- 836
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAARrr 80
|
90 100
....*....|....*....|...
gi 1063680967 837 --------HELASLYGDHSDHLA 851
Cdd:pfam04408 81 rraadekaRAKFARLDLEGDHLT 103
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
217-395 |
3.27e-21 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 92.65 E-value: 3.27e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 217 LPIASFRDAIISAVESNQ-VVLIAGETGCGKTTQVPQYLLDHMWHSKKEACKIICTQPRRISAISVSDRISWERGETIGR 295
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAEFALSRGFQKGQVTVTQPHPLAARSLALRVADEMDLNLGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 296 TVGYKVRLQSEGGRESSVVFCTNGILLRVLigkgvnSSVPDITH---IIVDEIHERDSYSDFMLMILRDLLPSNPHLRLI 372
Cdd:cd17986 81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEM------TSTPLLGAwgvVVLDEAQERSVASDSLLGLLKDVRLQRPELRVV 154
|
170 180
....*....|....*....|...
gi 1063680967 373 LMSATLDAERFSEYFGGCPVVRV 395
Cdd:cd17986 155 VVTSPALEPKLRAFWGNPPVVHV 177
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
766-851 |
6.79e-19 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 82.70 E-value: 6.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 766 IGALTPEEELTELGQKFGQLPVHPRISKMIYFAILVNCLDPALILACAADEKDPFtmplspgDRKKAAAAKHELASLYGD 845
Cdd:smart00847 2 LGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR-------PKEKREDADAARRRFADP 74
|
....*.
gi 1063680967 846 HSDHLA 851
Cdd:smart00847 75 ESDHLT 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
563-693 |
2.38e-16 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 76.10 E-value: 2.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 563 VKLMKKICSDSKDGAILVFLPGWEEisktkeklLDDRFFAHSAKFIILCLHSRVPAEEQKKVFNRPPRGCRKIVLATNIA 642
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQTKKT--------LEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVA 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1063680967 643 ESAVTIDDVVYVIDsgrmkeksYDPYNDVSTLqsswvskanaKQRAGRAGR 693
Cdd:pfam00271 75 ERGLDLPDVDLVIN--------YDLPWNPASY----------IQRIGRAGR 107
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
236-377 |
7.34e-15 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 73.21 E-value: 7.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 236 VLIAGETGCGKTTQVPQYLLDHMwhsKKEACKIICTQPRRISAISVSDRISWERGETIgrTVGY------KVRLQSEGGR 309
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLL---LKKGKKVLVLVPTKALALQTAERLRELFGPGI--RVAVlvggssAEEREKNKLG 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063680967 310 ESSVVFCTNGILLRvLIGKGVNSSVPDITHIIVDEIHERDSYSDFMLMILRDLLPSNPH-LRLILMSAT 377
Cdd:cd00046 79 DADIIIATPDMLLN-LLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLKnAQVILLSAT 146
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
604-693 |
3.19e-14 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 69.16 E-value: 3.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 604 SAKFIILCLHSRVPAEEQKKVFNRPPRGCRKIVLATNIAESAVTIDDVVYVIDsgrmkeksYDPyndvstlqssWVSKAN 683
Cdd:smart00490 9 ELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVII--------YDL----------PWSPAS 70
|
90
....*....|
gi 1063680967 684 AKQRAGRAGR 693
Cdd:smart00490 71 YIQRIGRAGR 80
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
215-442 |
2.19e-13 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 75.01 E-value: 2.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 215 SKLPIASFR----DAIISAVESNQVVLIAGETGCGKTTQVPQYLL---------------DHMWHSKKeackIICTQPRr 275
Cdd:PHA02653 157 SKIPLASLQpdvqLKIFEAWISRKPVVLTGGTGVGKTSQVPKLLLwfnylfggfdnldkiDPNFIERP----IVLSLPR- 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 276 ISAISVSdriswerGETIGRTVGYK------VRLQSEGGRESSV---------VFCTNgillRVLIGKGVNSSVpdithI 340
Cdd:PHA02653 232 VALVRLH-------SITLLKSLGFDeidgspISLKYGSIPDELIntnpkpyglVFSTH----KLTLNKLFDYGT-----V 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 341 IVDEIHERDSYSDFMLMILRDlLPSNPHlRLILMSATL--DAERFSEYFGGCPVVRVPGFT-YPVRTFFLDDALSVLNsd 417
Cdd:PHA02653 296 IIDEVHEHDQIGDIIIAVARK-HIDKIR-SLFLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPISEVYVKNKYNPKN-- 371
|
250 260
....*....|....*....|....*
gi 1063680967 418 knshllsavKRDFKDEDKVSLDEAI 442
Cdd:PHA02653 372 ---------KRAYIEEEKKNIVTAL 387
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
225-381 |
5.58e-11 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 62.65 E-value: 5.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 225 AIISAVESNQVVLIAGETGCGKTT--QVPqyLLDHMWHsKKEACKIICTQPRRISAISVSDRISwERGETIGRTV----- 297
Cdd:pfam00270 6 EAIPAILEGRDVLVQAPTGSGKTLafLLP--ALEALDK-LDNGPQALVLAPTRELAEQIYEELK-KLGKGLGLKVasllg 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 298 GYKVRLQSEGGRESSVVFCTNGILLRVLIGKGVNSSVpdiTHIIVDEIHE--RDSYSDFMLMILRDLlpsNPHLRLILMS 375
Cdd:pfam00270 82 GDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNL---KLLVLDEAHRllDMGFGPDLEEILRRL---PKKRQILLLS 155
|
....*.
gi 1063680967 376 ATLDAE 381
Cdd:pfam00270 156 ATLPRN 161
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
919-1007 |
3.07e-10 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 58.03 E-value: 3.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 919 LRAVIAVGLYPMLGRMCPLSKNRTRSVIetiaGAKVRVPSLSNNVdmSSTKFDEALIVFDEITRGDWgVVIRSCTVLPTI 998
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGYTTLSD----NQRVFIHPSSVLF--NEKTFPPEWVVYQELVETTK-VYIRTVTAISPE 73
|
....*....
gi 1063680967 999 PVLLFSREI 1007
Cdd:pfam07717 74 WLLLFAPHI 82
|
|
| R3H_NRF |
cd02640 |
R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB ... |
23-76 |
3.94e-10 |
|
R3H domain of the NF-kappaB-repression factor (NRF). NRF is a nuclear inhibitor of NF-kappaB proteins that can silence the IFNbeta promoter via binding to a negative regulatory element (NRE). Beside R3H NRF also contains a G-patch domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Pssm-ID: 100069 Cd Length: 60 Bit Score: 57.02 E-value: 3.94e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1063680967 23 KVLEDFRASGND-SYVFEQQLTNSERGIIHQMCRTMGLRSKSNGSGEERRLSLFK 76
Cdd:cd02640 6 QIIQNYAHSDDIrDMVFSPEFSKEERALIHQIAQKYGLKSRSYGSGNDRYLVISK 60
|
|
| R3H |
cd02325 |
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ... |
23-76 |
6.10e-09 |
|
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Pssm-ID: 100064 Cd Length: 59 Bit Score: 53.39 E-value: 6.10e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1063680967 23 KVLEDFRASGN-DSYVFEQqLTNSERGIIHQMCRTMGLRSKSNGSGEERRLSLFK 76
Cdd:cd02325 6 EELEAFAKDAAgKSLELPP-MNSYERKLIHDLAEYYGLKSESEGEGPNRRVVITK 59
|
|
| R3H |
smart00393 |
Putative single-stranded nucleic acids-binding domain; |
25-76 |
2.24e-08 |
|
Putative single-stranded nucleic acids-binding domain;
Pssm-ID: 214647 Cd Length: 79 Bit Score: 52.69 E-value: 2.24e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1063680967 25 LEDFRASGNDSYVFEQqLTNSERGIIHQMCRTMGLRSKSNGSGEERRLSLFK 76
Cdd:smart00393 28 IARFVKSTKESVELPP-MNSYERKIVHELAEKYGLESESFGEGPKRRVVISK 78
|
|
| R3H |
pfam01424 |
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ... |
23-76 |
2.32e-07 |
|
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.
Pssm-ID: 460206 Cd Length: 60 Bit Score: 49.03 E-value: 2.32e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1063680967 23 KVLEDFRASGNDSYVFEQqLTNSERGIIHQMCRTMGLRSKSNGSGEERRLSLFK 76
Cdd:pfam01424 8 EKLAEFVKDTGKSLELPP-MSSYERRIIHELAQKYGLESESEGEEPNRRVVVYK 60
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
223-388 |
2.57e-07 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 52.26 E-value: 2.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 223 RDAIISAVESNQVVLIAGETGCGKTTqVPQYLLDHMWhsKKEACKIICTQPRRisAIS------VSDRISWERGETIGRT 296
Cdd:cd17921 7 REALRALYLSGDSVLVSAPTSSGKTL-IAELAILRAL--ATSGGKAVYIAPTR--ALVnqkeadLRERFGPLGKNVGLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 297 VGYKVRLQSEGgrESSVVFCTNGILlRVLIGKGVNSSVPDITHIIVDEIHERDSYSDFMLM--ILRDLLPSNPHLRLILM 374
Cdd:cd17921 82 GDPSVNKLLLA--EADILVATPEKL-DLLLRNGGERLIQDVRLVVVDEAHLIGDGERGVVLelLLSRLLRINKNARFVGL 158
|
170
....*....|....*
gi 1063680967 375 SATLD-AERFSEYFG 388
Cdd:cd17921 159 SATLPnAEDLAEWLG 173
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
468-575 |
2.24e-06 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 51.11 E-value: 2.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 468 NYQNSTtGLTPLMVFAGKGRVSDVCKLLSVGADCTLKSKEGITALELAEKENQFETAQIIREHAGNIQSNSQQAQDLLDK 547
Cdd:COG0666 180 NARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258
|
90 100
....*....|....*....|....*...
gi 1063680967 548 YMATIKPEEVDVGLIVKLMKKICSDSKD 575
Cdd:COG0666 259 AAAAGAALIVKLLLLALLLLAAALLDLL 286
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
407-610 |
1.26e-04 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 45.72 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 407 LDDALSVLNSDKNSHLLSAVKRDFKDEDKVSLDEAIDLAWTNDEFDCLVDLVSSEGSHEAY----------NYQNSTtGL 476
Cdd:COG0666 76 AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVkllleagadvNAQDND-GN 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 477 TPLMVFAGKGRVSDVCKLLSVGADCTLKSKEGITALELAEKENQFETAQIIREHAGNIQSNSQQAQDLLDkyMATIKPEE 556
Cdd:COG0666 155 TPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALD--LAAENGNL 232
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1063680967 557 VDVGLIVKLMKKICSDSKDGAILVFLPGWEEISKTKEKLLDDRFFAHSAKFIIL 610
Cdd:COG0666 233 EIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
475-515 |
1.59e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 40.79 E-value: 1.59e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1063680967 475 GLTPLMVFAGKGRVSDVCKLLSVGADCTLKSKEGITALELA 515
Cdd:pfam13857 16 GYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
475-530 |
3.59e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 45.27 E-value: 3.59e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1063680967 475 GLTPLMVFAGKGRVSDVCKLLSVGADCTLKSKEGITALELAEKENQFETAQIIREH 530
Cdd:PTZ00322 115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
|
|
| R3H_RRM |
cd02639 |
R3H domain of mainly fungal proteins which are associated with a RNA recognition motif (RRM) ... |
34-76 |
6.89e-04 |
|
R3H domain of mainly fungal proteins which are associated with a RNA recognition motif (RRM) domain. Present in this group is the RNA-binding post-transcriptional regulator Cip2 (Csx1-interacting protein 2) involved in counteracting Csx1 function. Csx1 plays a central role in controlling gene expression during oxidative stress. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.
Pssm-ID: 100068 Cd Length: 60 Bit Score: 39.20 E-value: 6.89e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1063680967 34 DSYVFEQQLTNSERGIIHQMCRTMGLRSKSNGSGEERRLSLFK 76
Cdd:cd02639 18 DELAFPSSLSPAERRIVHLLASRLGLNHVSDGTGERRQVQITK 60
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
407-534 |
1.05e-03 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 43.02 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680967 407 LDDALSVLNSDKNSHLLSAVKRDFKDEDKVSLDEAIDLAWTNDEFDCLVDLVSSEGSHEAYNYQNSTTGLTPLMVFAGKG 486
Cdd:COG0666 19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1063680967 487 RVSDVCKLLSVGADCTLKSKEGITALELAEKENQFETAQIIREHAGNI 534
Cdd:COG0666 99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADV 146
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
470-537 |
1.14e-03 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 39.71 E-value: 1.14e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063680967 470 QNSTTGLTPLMVFAGKGRVsDVCKLLSVGADCTLKSkEGITALELAEKENQFETAQIIREHAGNIQSN 537
Cdd:pfam12796 25 LQDKNGRTALHLAAKNGHL-EIVKLLLEHADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADINVK 90
|
|
| |
