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Conserved domains on  [gi|1063679355|ref|NP_001322242|]
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Ribosomal RNA adenine dimethylase family protein [Arabidopsis thaliana]

Protein Classification

ribosomal RNA small subunit methyltransferase A( domain architecture ID 10000482)

ribosomal RNA small subunit methyltransferase A specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle

CATH:  2.20.25.110
EC:  2.1.1.-|2.1.1.182
Gene Ontology:  GO:1904047|GO:0052908|GO:0031167
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 8-263 9.27e-74

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 226.16  E-value: 9.27e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355   8 DQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDKFKVLQEDFVKCHIRshmlSILE 87
Cdd:COG0030    27 RRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAYPNLTVIEGDALKVDLP----ALAA 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355  88 TRRLshpdsalaKVVSNLPFNISTDVVKLLLPMGDIFSKVVLLLQDEAALRLVEPAlRTSEYRPINILINFYSEPEYNFR 167
Cdd:COG0030   103 GEPL--------KVVGNLPYNISTPILFKLLEARPPIEDAVLMVQKEVAERLVAKP-GSKDYGRLSVLVQYYADVEILFT 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355 168 VPRENFFPQPKVDAAVVTFKLKHPRDYPdVSSTKNFFSLVNSAFNGKRKMLRKSLQHISSSPDIEKALGVAGLPATSRPE 247
Cdd:COG0030   174 VPPEAFYPPPKVDSAVVRLTPRPEPLVP-VADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEALEAAGIDPTARAE 252

                         250
                  ....*....|....*.
gi 1063679355 248 ELTLDDFVKLHNVIAR 263
Cdd:COG0030   253 ELSVEEFARLANALKK 268
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 8-263 9.27e-74

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 226.16  E-value: 9.27e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355   8 DQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDKFKVLQEDFVKCHIRshmlSILE 87
Cdd:COG0030    27 RRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAYPNLTVIEGDALKVDLP----ALAA 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355  88 TRRLshpdsalaKVVSNLPFNISTDVVKLLLPMGDIFSKVVLLLQDEAALRLVEPAlRTSEYRPINILINFYSEPEYNFR 167
Cdd:COG0030   103 GEPL--------KVVGNLPYNISTPILFKLLEARPPIEDAVLMVQKEVAERLVAKP-GSKDYGRLSVLVQYYADVEILFT 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355 168 VPRENFFPQPKVDAAVVTFKLKHPRDYPdVSSTKNFFSLVNSAFNGKRKMLRKSLQHISSSPDIEKALGVAGLPATSRPE 247
Cdd:COG0030   174 VPPEAFYPPPKVDSAVVRLTPRPEPLVP-VADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEALEAAGIDPTARAE 252

                         250
                  ....*....|....*.
gi 1063679355 248 ELTLDDFVKLHNVIAR 263
Cdd:COG0030   253 ELSVEEFARLANALKK 268
rADc smart00650
Ribosomal RNA adenine dimethylases;
6-190 7.18e-58

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 181.94  E-value: 7.18e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355    6 INDQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDKFKVLQEDFVKCHirshmlsi 85
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFAAADNLTVIHGDALKFD-------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355   86 letrrlsHPDSALAKVVSNLPFNISTDVVKLLLPMGDIFSKVVLLLQDEAALRLVEPALrTSEYRPINILINFYSEPEYN 165
Cdd:smart00650  73 -------LPKLQPYKVVGNLPYNISTPILFKLLEEPPAFRDAVLMVQKEVARRLAAKPG-SKDYGRLSVLLQPYADVKIL 144

                          170       180
                   ....*....|....*....|....*
gi 1063679355  166 FRVPRENFFPQPKVDAAVVTFKLKH 190
Cdd:smart00650 145 FKVPPSAFRPPPKVDSAVVRLERRP 169
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 3-259 1.44e-52

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 171.26  E-value: 1.44e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355   3 NSDINDQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDKFKVLQEDFVKchirshm 82
Cdd:TIGR00755  14 DENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLLSLYNNLEIIEGDALK------- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355  83 lsiletRRLSHPDSALAKVVSNLPFNISTDVVKLLLPMGDIFSKVVLLLQDEAALRLV-EPalRTSEYRPINILINFYSE 161
Cdd:TIGR00755  87 ------FDLNELAKDLTKVVGNLPYNISSPLIFKLLKEKDAFKLAVLMVQKEVAERLVaKP--GSKDYGRLSVLVQYYAN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355 162 PEYNFRVPRENFFPQPKVDAAVVTFKLKHPRDYPDvsSTKNFFSLVNSAFNGKRKMLRKSLQHisSSPDIEKALGVAGLP 241
Cdd:TIGR00755 159 VEIVFKVPPSAFYPPPKVDSAVVRLVPLKRKPSPK--DFALFEELLKAAFQQRRKTLRNNLKN--LLSELVELLEELGID 234

                         250
                  ....*....|....*...
gi 1063679355 242 ATSRPEELTLDDFVKLHN 259
Cdd:TIGR00755 235 PDKRVEQLSPEDFLRLAN 252
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
5-261 7.40e-42

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 143.89  E-value: 7.40e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355   5 DINDQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDKFKVLQEDFVKChirshmls 84
Cdd:PRK14896   16 RVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAAGNVEIIEGDALKV-------- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355  85 iletrrlshPDSALAKVVSNLPFNISTDVVKLLLPMGdiFSKVVLLLQDEAALRLVEPAlRTSEYRPINILINFYSEPEY 164
Cdd:PRK14896   88 ---------DLPEFNKVVSNLPYQISSPITFKLLKHG--FEPAVLMYQKEFAERMVAKP-GTKEYGRLSVMVQYYADVEI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355 165 NFRVPRENFFPQPKVDAAVVTFKlkhPRDYPDVSSTKNFFSLVNSA-FNGKRKMLRKSLQ---HISSSPDIEKALGVAGL 240
Cdd:PRK14896  156 VEKVPPGAFSPKPKVDSAVVRLT---PREPKYEVYDEDFFDDFVKAlFQHRRKTLRNALKnsaHISGKEDIKAVVEALPE 232

                         250       260
                  ....*....|....*....|..
gi 1063679355 241 P-ATSRPEELTLDDFVKLHNVI 261
Cdd:PRK14896  233 ElLNKRVFQLSPEEIAELANLL 254
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
8-262 1.76e-35

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 127.48  E-value: 1.76e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355   8 DQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDKFKVLQEDFVKCHIRSHMLSILE 87
Cdd:pfam00398  20 NEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSLDENLTVIHQDFLKFEFPSLVTHIHQ 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355  88 trrlshPDsalaKVVSNLPFNISTDVVKLLLPMG-DIFSKVVLLLQDEAALRLVEPAlRTSEYRPINILINFYSEPEYNF 166
Cdd:pfam00398 100 ------EF----LVVGNLPYNISTPIVKQLLFESrFGIVDMLLMLQKEFARRLLARP-GSKLYSRLSVLRQAFTDVKLVA 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355 167 RVPRENFFPQPKVDAAVVTFKLKHPRDYPDVsSTKNFFSLVNSAFNGKRKMLRKSLQHIsSSPDIEKALGVAGLPATSRP 246
Cdd:pfam00398 169 KVPPSIFSPPPKVDSALVRLERHDPDPHPVK-DLDVYDSVVRKLFNRKRKTLSTSLKSL-FPGGQLQAFSSHGINDNALV 246

                         250
                  ....*....|....*.
gi 1063679355 247 EELTLDDFVKLHNVIA 262
Cdd:pfam00398 247 KKLSPEQTLDIFNELA 262
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 8-263 9.27e-74

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 226.16  E-value: 9.27e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355   8 DQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDKFKVLQEDFVKCHIRshmlSILE 87
Cdd:COG0030    27 RRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAYPNLTVIEGDALKVDLP----ALAA 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355  88 TRRLshpdsalaKVVSNLPFNISTDVVKLLLPMGDIFSKVVLLLQDEAALRLVEPAlRTSEYRPINILINFYSEPEYNFR 167
Cdd:COG0030   103 GEPL--------KVVGNLPYNISTPILFKLLEARPPIEDAVLMVQKEVAERLVAKP-GSKDYGRLSVLVQYYADVEILFT 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355 168 VPRENFFPQPKVDAAVVTFKLKHPRDYPdVSSTKNFFSLVNSAFNGKRKMLRKSLQHISSSPDIEKALGVAGLPATSRPE 247
Cdd:COG0030   174 VPPEAFYPPPKVDSAVVRLTPRPEPLVP-VADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEALEAAGIDPTARAE 252

                         250
                  ....*....|....*.
gi 1063679355 248 ELTLDDFVKLHNVIAR 263
Cdd:COG0030   253 ELSVEEFARLANALKK 268
rADc smart00650
Ribosomal RNA adenine dimethylases;
6-190 7.18e-58

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 181.94  E-value: 7.18e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355    6 INDQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDKFKVLQEDFVKCHirshmlsi 85
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFAAADNLTVIHGDALKFD-------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355   86 letrrlsHPDSALAKVVSNLPFNISTDVVKLLLPMGDIFSKVVLLLQDEAALRLVEPALrTSEYRPINILINFYSEPEYN 165
Cdd:smart00650  73 -------LPKLQPYKVVGNLPYNISTPILFKLLEEPPAFRDAVLMVQKEVARRLAAKPG-SKDYGRLSVLLQPYADVKIL 144

                          170       180
                   ....*....|....*....|....*
gi 1063679355  166 FRVPRENFFPQPKVDAAVVTFKLKH 190
Cdd:smart00650 145 FKVPPSAFRPPPKVDSAVVRLERRP 169
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 3-259 1.44e-52

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 171.26  E-value: 1.44e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355   3 NSDINDQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDKFKVLQEDFVKchirshm 82
Cdd:TIGR00755  14 DENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLLSLYNNLEIIEGDALK------- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355  83 lsiletRRLSHPDSALAKVVSNLPFNISTDVVKLLLPMGDIFSKVVLLLQDEAALRLV-EPalRTSEYRPINILINFYSE 161
Cdd:TIGR00755  87 ------FDLNELAKDLTKVVGNLPYNISSPLIFKLLKEKDAFKLAVLMVQKEVAERLVaKP--GSKDYGRLSVLVQYYAN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355 162 PEYNFRVPRENFFPQPKVDAAVVTFKLKHPRDYPDvsSTKNFFSLVNSAFNGKRKMLRKSLQHisSSPDIEKALGVAGLP 241
Cdd:TIGR00755 159 VEIVFKVPPSAFYPPPKVDSAVVRLVPLKRKPSPK--DFALFEELLKAAFQQRRKTLRNNLKN--LLSELVELLEELGID 234

                         250
                  ....*....|....*...
gi 1063679355 242 ATSRPEELTLDDFVKLHN 259
Cdd:TIGR00755 235 PDKRVEQLSPEDFLRLAN 252
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
5-261 7.40e-42

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 143.89  E-value: 7.40e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355   5 DINDQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDKFKVLQEDFVKChirshmls 84
Cdd:PRK14896   16 RVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAAGNVEIIEGDALKV-------- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355  85 iletrrlshPDSALAKVVSNLPFNISTDVVKLLLPMGdiFSKVVLLLQDEAALRLVEPAlRTSEYRPINILINFYSEPEY 164
Cdd:PRK14896   88 ---------DLPEFNKVVSNLPYQISSPITFKLLKHG--FEPAVLMYQKEFAERMVAKP-GTKEYGRLSVMVQYYADVEI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355 165 NFRVPRENFFPQPKVDAAVVTFKlkhPRDYPDVSSTKNFFSLVNSA-FNGKRKMLRKSLQ---HISSSPDIEKALGVAGL 240
Cdd:PRK14896  156 VEKVPPGAFSPKPKVDSAVVRLT---PREPKYEVYDEDFFDDFVKAlFQHRRKTLRNALKnsaHISGKEDIKAVVEALPE 232

                         250       260
                  ....*....|....*....|..
gi 1063679355 241 P-ATSRPEELTLDDFVKLHNVI 261
Cdd:PRK14896  233 ElLNKRVFQLSPEEIAELANLL 254
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
8-262 1.76e-35

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 127.48  E-value: 1.76e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355   8 DQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDKFKVLQEDFVKCHIRSHMLSILE 87
Cdd:pfam00398  20 NEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSLDENLTVIHQDFLKFEFPSLVTHIHQ 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355  88 trrlshPDsalaKVVSNLPFNISTDVVKLLLPMG-DIFSKVVLLLQDEAALRLVEPAlRTSEYRPINILINFYSEPEYNF 166
Cdd:pfam00398 100 ------EF----LVVGNLPYNISTPIVKQLLFESrFGIVDMLLMLQKEFARRLLARP-GSKLYSRLSVLRQAFTDVKLVA 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355 167 RVPRENFFPQPKVDAAVVTFKLKHPRDYPDVsSTKNFFSLVNSAFNGKRKMLRKSLQHIsSSPDIEKALGVAGLPATSRP 246
Cdd:pfam00398 169 KVPPSIFSPPPKVDSALVRLERHDPDPHPVK-DLDVYDSVVRKLFNRKRKTLSTSLKSL-FPGGQLQAFSSHGINDNALV 246

                         250
                  ....*....|....*.
gi 1063679355 247 EELTLDDFVKLHNVIA 262
Cdd:pfam00398 247 KKLSPEQTLDIFNELA 262
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 3-219 4.91e-26

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 103.16  E-value: 4.91e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355   3 NSDINDQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGS---DKFKVLQEDFVKCHIr 79
Cdd:PTZ00338   21 NPLVLDKIVEKAAIKPTDTVLEIGPGTGNLTEKLLQLAKKVIAIEIDPRMVAELKKRFQNSplaSKLEVIEGDALKTEF- 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355  80 shmlsiletrrlshPDsaLAKVVSNLPFNISTDVVKLLLPMGDIFSKVVLLLQDEAALRLV-EPAlrTSEYRPINILINF 158
Cdd:PTZ00338  100 --------------PY--FDVCVANVPYQISSPLVFKLLAHRPLFRCAVLMFQKEFALRLLaQPG--DELYCRLSVNTQL 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063679355 159 YSEPEYNFRVPRENFFPQPKVDAAVVTFKLKHPRdyPDVsstkNFFS---LVNSAFNGKRKMLR 219
Cdd:PTZ00338  162 LCRVTHLMKVSKNSFNPPPKVESSVVRIEPKNPP--PDV----DFEEwdgLLRICFSRKNKTLS 219
COG3963 COG3963
Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];
8-118 5.56e-10

Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];


Pssm-ID: 443163  Cd Length: 193  Bit Score: 57.14  E-value: 5.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355   8 DQLASAADVKEGDFVLEIGPGTGSLTNVLINLG---ATVLAIEKDPHMVDLVSERFAGsdkFKVLQEDFVkchirsHMLS 84
Cdd:COG3963    35 RAMASEVDWSGAGPVVELGPGTGVFTRAILARGvpdARLLAVEINPEFAEHLRRRFPR---VTVVNGDAE------DLAE 105

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1063679355  85 ILETRRLSHPDSalakVVSNLPF-NISTDVVKLLL 118
Cdd:COG3963   106 LLAEHGIGKVDA----VVSGLPLlSFPPELRRAIL 136
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 5-61 3.72e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 48.45  E-value: 3.72e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063679355   5 DINDQLASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFA 61
Cdd:COG2226     9 DGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAA 65
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 13-61 9.59e-07

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 48.16  E-value: 9.59e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1063679355  13 AADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFA 61
Cdd:COG2518    61 ALDLKPGDRVLEIGTGSGYQAAVLARLAGRVYSVERDPELAERARERLA 109
PRK14968 PRK14968
putative methyltransferase; Provisional
 10-76 8.67e-06

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 45.27  E-value: 8.67e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063679355  10 LASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFA----GSDKFKVLQEDFVKC 76
Cdd:PRK14968   15 LAENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKlnniRNNGVEVIRSDLFEP 85
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 10-148 1.74e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 44.75  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355  10 LASAADVKEGDFVLEIGPGTGSLTnvLI----NLGATVLAIEKDPHMVDLVSERFAGS---DKFKVLQEDFvkchirSHM 82
Cdd:COG4123    29 LAAFAPVKKGGRVLDLGTGTGVIA--LMlaqrSPGARITGVEIQPEAAELARRNVALNgleDRITVIHGDL------KEF 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063679355  83 LSILETRRLSHpdsalakVVSNLPFNISTDVVK------------LLLPMGDIFSKVVLLLQDEAALRLVEPALRTSE 148
Cdd:COG4123   101 AAELPPGSFDL-------VVSNPPYFKAGSGRKspdearaiarheDALTLEDLIRAAARLLKPGGRFALIHPAERLAE 171
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 23-73 7.52e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 40.73  E-value: 7.52e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063679355  23 LEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGsDKFKVLQEDF 73
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPR-EGLTFVVGDA 50
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 22-105 1.26e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 40.77  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355  22 VLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDkFKVLQEDFVKCHIRSH------MLSILEtrRLSHPD 95
Cdd:COG2227    28 VLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAELN-VDFVQGDLEDLPLEDGsfdlviCSEVLE--HLPDPA 104

                          90
                  ....*....|
gi 1063679355  96 SALAKVVSNL 105
Cdd:COG2227   105 ALLRELARLL 114
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 22-73 1.95e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 39.47  E-value: 1.95e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063679355  22 VLEIGPGTGSLTNVLIN-LGATVLAIEKDPHMVDLVSERFAGSD-KFKVLQEDF 73
Cdd:pfam13649   1 VLDLGCGTGRLTLALARrGGARVTGVDLSPEMLERARERAAEAGlNVEFVQGDA 54
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 23-105 3.00e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 38.89  E-value: 3.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355  23 LEIGPGTGSLTNVLINL--GATVLAIEKDPHMVDLVSERFAGSDKFKVLQEDFVKCHIRS---------HMLSILEtrRL 91
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlpGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGEldpgsfdvvVASNVLH--HL 78

                          90
                  ....*....|....
gi 1063679355  92 SHPDSALAKVVSNL 105
Cdd:pfam08242  79 ADPRAVLRNIRRLL 92
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
22-62 5.54e-04

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 38.27  E-value: 5.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1063679355  22 VLEIGPGTGSLTNVLINL--GATVLAIEKDPHMVDLVSERFAG 62
Cdd:COG4106     5 VLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARLPN 47
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 1-69 9.01e-04

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 39.40  E-value: 9.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063679355   1 MLNSDINDQLASAADVKEGDFVLEIGPGTGSLT---NVLINLGATVLAIEKDPHMVDLVSErfaGSDKFKVL 69
Cdd:PRK00377   23 MTKEEIRALALSKLRLRKGDMILDIGCGTGSVTveaSLLVGETGKVYAVDKDEKAINLTRR---NAEKFGVL 91
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 8-73 1.41e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 38.37  E-value: 1.41e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355   8 DQLASAADVKEGDFVLEIGPGTGSLTNVLI-NLGATVLAIEKDPHMVDLVSERFAG---SDKFKVLQEDF 73
Cdd:COG2230    41 DLILRKLGLKPGMRVLDIGCGWGGLALYLArRYGVRVTGVTLSPEQLEYARERAAEaglADRVEVRLADY 110
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 10-73 2.10e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 38.36  E-value: 2.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063679355  10 LASAADVKEGDFVLEIGPGTGSLTNVLINL-GATVLAIEKDPHMVDLVSERF--AGSDKFKVLQEDF 73
Cdd:COG0500    18 LALLERLPKGGRVLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIALARARAakAGLGNVEFLVADL 84
PRK08317 PRK08317
hypothetical protein; Provisional
 12-63 2.40e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 38.38  E-value: 2.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063679355  12 SAADVKEGDFVLEIGPGTGSLTNVLINL---GATVLAIEKDPHMVDLVSERFAGS 63
Cdd:PRK08317   13 ELLAVQPGDRVLDVGCGPGNDARELARRvgpEGRVVGIDRSEAMLALAKERAAGL 67
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 13-61 2.42e-03

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 38.88  E-value: 2.42e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063679355  13 AADVKEGDFVLEIGPGTGSLTNVLIN-LGA-TVLAIEKDPHMVDLVSERFA 61
Cdd:TIGR04188 102 ALDVEDGHRVLEIGTGTGYSAALLCHrLGDdNVTSVEVDPGLAARAASALA 152
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 10-111 3.14e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 37.62  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063679355  10 LASAADVKEGDFVLEigP--GTGSltnVLI---NLGATVLAIEKDPHMVDLVSE--RFAGSDKFKVLQEDFvkchirshm 82
Cdd:COG1041    18 LVNLAGAKEGDTVLD--PfcGTGT---ILIeagLLGRRVIGSDIDPKMVEGAREnlEHYGYEDADVIRGDA--------- 83

                          90       100
                  ....*....|....*....|....*....
gi 1063679355  83 lsiletRRLSHPDSALAKVVSNLPFNIST 111
Cdd:COG1041    84 ------RDLPLADESVDAIVTDPPYGRSS 106
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 10-75 6.45e-03

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 36.76  E-value: 6.45e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063679355  10 LASAADVKEGDFVLEIGPGTGSLTNVLINLGATVLAIEKDPHMVDLVSERFAGSDK-FKVLQEDFVK 75
Cdd:TIGR00537  11 LEANLRELKPDDVLEIGAGTGLVAIRLKGKGKCILTTDINPFAVKELRENAKLNNVgLDVVMTDLFK 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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