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Conserved domains on  [gi|1063680073|ref|NP_001322271|]
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Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

Protein Classification

HAT repeat-containing protein( domain architecture ID 10647625)

HAT (Half-A-TPR) repeat-containing protein similar to Candida albicans pre-mRNA-splicing factor CLF1 that is involved in pre-mRNA splicing and cell cycle progression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HAT smart00386
HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and ...
 156-188 3.82e-04

HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and sequentially thought to be similar to TPRs.


:

Pssm-ID: 214642 [Multi-domain]  Cd Length: 33  Bit Score: 37.91  E-value: 3.82e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1063680073  156 GDFNKVVKLYERCVVTCANYPEYWIRYVTNMEA 188
Cdd:smart00386   1 GDIERARKIYERALEKFPKSVELWLKYAEFEER 33
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 153-274 8.14e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680073 153 ERDGDFNKVVKLYERCVVTCANYPEYWIRYVTNMEASGSADLAENALARATQVFvKKQPEIHLFAARLKEQNGDIAGARA 232
Cdd:COG4783    15 LLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELD-PDEPEARLNLGLALLKAGDYDEALA 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1063680073 233 AYQLVHsEISPGLLEAVIKHANMEYRLGNLDDAFSLYEQVIA 274
Cdd:COG4783    94 LLEKAL-KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
 
Name Accession Description Interval E-value
HAT smart00386
HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and ...
 156-188 3.82e-04

HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and sequentially thought to be similar to TPRs.


Pssm-ID: 214642 [Multi-domain]  Cd Length: 33  Bit Score: 37.91  E-value: 3.82e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1063680073  156 GDFNKVVKLYERCVVTCANYPEYWIRYVTNMEA 188
Cdd:smart00386   1 GDIERARKIYERALEKFPKSVELWLKYAEFEER 33
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 153-274 8.14e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680073 153 ERDGDFNKVVKLYERCVVTCANYPEYWIRYVTNMEASGSADLAENALARATQVFvKKQPEIHLFAARLKEQNGDIAGARA 232
Cdd:COG4783    15 LLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELD-PDEPEARLNLGLALLKAGDYDEALA 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1063680073 233 AYQLVHsEISPGLLEAVIKHANMEYRLGNLDDAFSLYEQVIA 274
Cdd:COG4783    94 LLEKAL-KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 190-322 4.37e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 4.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680073 190 GSADLAENALARATQVF---VKKQPEiHLFA----ARLKEQNGDIAGARAAYQLVhSEISPGLLEAVIKHANMEYRLGNL 262
Cdd:TIGR02917 472 GAIYLGKGDLAKAREAFekaLSIEPD-FFPAaanlARIDIQEGNPDDAIQRFEKV-LTIDPKNLRAILALAGLYLRTGNE 549

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680073 263 DDAFSLYEQVIAVEKGKEHstiLPLLYAQYsrfsYLVSRDAEKARRIIVEALDhVQPSKP 322
Cdd:TIGR02917 550 EEAVAWLEKAAELNPQEIE---PALALAQY----YLGKGQLKKALAILNEAAD-AAPDSP 601
 
Name Accession Description Interval E-value
HAT smart00386
HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and ...
 156-188 3.82e-04

HAT (Half-A-TPR) repeats; Present in several RNA-binding proteins. Structurally and sequentially thought to be similar to TPRs.


Pssm-ID: 214642 [Multi-domain]  Cd Length: 33  Bit Score: 37.91  E-value: 3.82e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1063680073  156 GDFNKVVKLYERCVVTCANYPEYWIRYVTNMEA 188
Cdd:smart00386   1 GDIERARKIYERALEKFPKSVELWLKYAEFEER 33
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 153-274 8.14e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680073 153 ERDGDFNKVVKLYERCVVTCANYPEYWIRYVTNMEASGSADLAENALARATQVFvKKQPEIHLFAARLKEQNGDIAGARA 232
Cdd:COG4783    15 LLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELD-PDEPEARLNLGLALLKAGDYDEALA 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1063680073 233 AYQLVHsEISPGLLEAVIKHANMEYRLGNLDDAFSLYEQVIA 274
Cdd:COG4783    94 LLEKAL-KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 186-276 1.56e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.13  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680073 186 MEASGSADLAENALARATQVFVKKQPEIHLFAARLKEQnGDIAGARAAYQLVHsEISPGLLEAVIKHANMEYRLGNLDDA 265
Cdd:COG3914    88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLAL-GRLEEALAALRRAL-ALNPDFAEAYLNLGEALRRLGRLEEA 165

                          90
                  ....*....|.
gi 1063680073 266 FSLYEQVIAVE 276
Cdd:COG3914   166 IAALRRALELD 176
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 153-349 2.96e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680073 153 ERDGDFNKVVKLYERCVVTCANYPEYWIRYVTNMEASGSADLAENALARATQVfVKKQPEIHLFAARLKEQNGDIAGARA 232
Cdd:COG2956    53 RRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLEL-DPDDAEALRLLAEIYEQEGDWEKAIE 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680073 233 AYQLVhSEISPGLLEAVIKHANMEYRLGNLDDAFSLYEQVIAVEKGKEHSTilpLLYAQYsrfsYLVSRDAEKARRIIVE 312
Cdd:COG2956   132 VLERL-LKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARAL---LLLAEL----YLEQGDYEEAIAALER 203

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1063680073 313 ALDHVQPSKPLMEALIH-FEAIQPPPREIDYLEPLVEK 349
Cdd:COG2956   204 ALEQDPDYLPALPRLAElYEKLGDPEEALELLRKALEL 241
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 190-322 4.37e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 4.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680073 190 GSADLAENALARATQVF---VKKQPEiHLFA----ARLKEQNGDIAGARAAYQLVhSEISPGLLEAVIKHANMEYRLGNL 262
Cdd:TIGR02917 472 GAIYLGKGDLAKAREAFekaLSIEPD-FFPAaanlARIDIQEGNPDDAIQRFEKV-LTIDPKNLRAILALAGLYLRTGNE 549

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680073 263 DDAFSLYEQVIAVEKGKEHstiLPLLYAQYsrfsYLVSRDAEKARRIIVEALDhVQPSKP 322
Cdd:TIGR02917 550 EEAVAWLEKAAELNPQEIE---PALALAQY----YLGKGQLKKALAILNEAAD-AAPDSP 601
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 156-253 5.25e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 37.29  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680073 156 GDFNKVVKLYERCVVTCANYPEYWIRYVTNMEASGSADLAENALARATQVfVKKQPEIHLFAARLKEQNGDIAGARAAYQ 235
Cdd:COG4235    31 GRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL-DPDNPEALYLLGLAAFQQGDYAEAIAAWQ 109

                          90
                  ....*....|....*...
gi 1063680073 236 LVHSEISPGLLEAVIKHA 253
Cdd:COG4235   110 KLLALLPADAPARLLEAS 127
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 174-275 7.69e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 7.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063680073 174 NYPEYWIRYVTNMEASGSADLAENALARATQvFVKKQPEIHLFAARLKEQNGDIAGARAAYQLVHsEISPGLLEAVIKHA 253
Cdd:COG4235    15 NDAEGWLLLGRAYLRLGRYDEALAAYEKALR-LDPDNADALLDLAEALLAAGDTEEAEELLERAL-ALDPDNPEALYLLG 92

                          90       100
                  ....*....|....*....|..
gi 1063680073 254 NMEYRLGNLDDAFSLYEQVIAV 275
Cdd:COG4235    93 LAAFQQGDYAEAIAAWQKLLAL 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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