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Conserved domains on  [gi|1063683417|ref|NP_001322548|]
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Cyclin family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 488-570 1.97e-27

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410310  Cd Length: 104  Bit Score: 106.44  E-value: 1.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 488 PTIFNFLWFYLKAAR-------ANPEVERKAKSLAVTSLSDQTQLCFWPSTVAAALVVLACIEHNKISAYQ------RVI 554
Cdd:cd20721     1 PTILTFLRMYIERLSlesgaahASRPLERLAMFLAEISLLHYSFLQFRPSTVAAACLVLAEIMHNRPAAWAaealsaELA 80

                          90
                  ....*....|....*.
gi 1063683417 555 KVHVRTTDNELPECVK 570
Cdd:cd20721    81 AVLVHTRAPEVLRCVQ 96
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 347-483 9.34e-17

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20507:

Pssm-ID: 477360 [Multi-domain]  Cd Length: 130  Bit Score: 76.80  E-value: 9.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 347 EEVEESYLRLRERERSHAYMRDcakaYCSRMDNtgLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKS 426
Cdd:cd20507     3 EYVKDIYKYLRQLEKKYAIDPD----YLSGQPE--ITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPR 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063683417 427 ERtLILVGIASLTLATRIEENQPyNSIRKRNFTIQNLrYSRHEVVAMEWLVQEVLNF 483
Cdd:cd20507    77 KK-LQLVGVTALLIASKYEEIYP-PEIKDFVYITDNA-YTREEILQMERDILKTLDF 130
 
Name Accession Description Interval E-value
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 488-570 1.97e-27

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410310  Cd Length: 104  Bit Score: 106.44  E-value: 1.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 488 PTIFNFLWFYLKAAR-------ANPEVERKAKSLAVTSLSDQTQLCFWPSTVAAALVVLACIEHNKISAYQ------RVI 554
Cdd:cd20721     1 PTILTFLRMYIERLSlesgaahASRPLERLAMFLAEISLLHYSFLQFRPSTVAAACLVLAEIMHNRPAAWAaealsaELA 80

                          90
                  ....*....|....*.
gi 1063683417 555 KVHVRTTDNELPECVK 570
Cdd:cd20721    81 AVLVHTRAPEVLRCVQ 96
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 347-483 9.34e-17

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 76.80  E-value: 9.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 347 EEVEESYLRLRERERSHAYMRDcakaYCSRMDNtgLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKS 426
Cdd:cd20507     3 EYVKDIYKYLRQLEKKYAIDPD----YLSGQPE--ITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPR 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063683417 427 ERtLILVGIASLTLATRIEENQPyNSIRKRNFTIQNLrYSRHEVVAMEWLVQEVLNF 483
Cdd:cd20507    77 KK-LQLVGVTALLIASKYEEIYP-PEIKDFVYITDNA-YTREEILQMERDILKTLDF 130
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 352-483 4.48e-16

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 74.86  E-value: 4.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 352 SYLRLRERE--RSHAYMrdcakaycsrMDNTGLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFkSERT 429
Cdd:pfam00134   4 QYLRELELKylPKPDYM----------DQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSV-PKNK 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 430 LILVGIASLTLATRIEENQPYnsirkrnfTIQNL------RYSRHEVVAMEWLVQEVLNF 483
Cdd:pfam00134  73 LQLVGVTCLFIAAKYEEIYPP--------TVEDLvyitdnAYTREEILRMERLILETLNF 124
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
386-540 4.60e-15

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 77.89  E-value: 4.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 386 LRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSERtLILVGIASLTLATRIEEnqpYNSIRKRNF-TIQNLR 464
Cdd:COG5024   212 MRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEK-YQLVGISALFIASKYEE---VNCPSIKDLvYATDGA 287

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063683417 465 YSRHEVVAMEWLVQEVLNFKCFTPTIFNFLWFYLKAARANPEVERKAKSLAVTSLSDQTQLCFWPSTVAAALVVLA 540
Cdd:COG5024   288 FTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLS 363
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 488-570 1.18e-07

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 50.70  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 488 PTIFNFLWFYLKAARANP--EVERKAKSLAVTSLSDQTQLCFWPSTVAAALVVLACIEHNKiSAYQRVIKVHVRTTDNEL 565
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHdlELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNS-PEWTETLEHYTGYSEEDL 79


                  ....*
gi 1063683417 566 PECVK 570
Cdd:pfam02984  80 KPCVK 84
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 392-474 5.37e-06

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 44.89  E-value: 5.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417  392 QWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFkSERTLILVGIASLTLATRIEENQPYNSIRKRNFTIqnlrYSRHEVV 471
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKF-LKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY----FTEEEIL 75


                   ...
gi 1063683417  472 AME 474
Cdd:smart00385  76 RME 78
 
Name Accession Description Interval E-value
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 488-570 1.97e-27

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410310  Cd Length: 104  Bit Score: 106.44  E-value: 1.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 488 PTIFNFLWFYLKAAR-------ANPEVERKAKSLAVTSLSDQTQLCFWPSTVAAALVVLACIEHNKISAYQ------RVI 554
Cdd:cd20721     1 PTILTFLRMYIERLSlesgaahASRPLERLAMFLAEISLLHYSFLQFRPSTVAAACLVLAEIMHNRPAAWAaealsaELA 80

                          90
                  ....*....|....*.
gi 1063683417 555 KVHVRTTDNELPECVK 570
Cdd:cd20721    81 AVLVHTRAPEVLRCVQ 96
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 347-483 9.34e-17

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 76.80  E-value: 9.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 347 EEVEESYLRLRERERSHAYMRDcakaYCSRMDNtgLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKS 426
Cdd:cd20507     3 EYVKDIYKYLRQLEKKYAIDPD----YLSGQPE--ITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPR 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063683417 427 ERtLILVGIASLTLATRIEENQPyNSIRKRNFTIQNLrYSRHEVVAMEWLVQEVLNF 483
Cdd:cd20507    77 KK-LQLVGVTALLIASKYEEIYP-PEIKDFVYITDNA-YTREEILQMERDILKTLDF 130
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 352-483 4.48e-16

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 74.86  E-value: 4.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 352 SYLRLRERE--RSHAYMrdcakaycsrMDNTGLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFkSERT 429
Cdd:pfam00134   4 QYLRELELKylPKPDYM----------DQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSV-PKNK 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 430 LILVGIASLTLATRIEENQPYnsirkrnfTIQNL------RYSRHEVVAMEWLVQEVLNF 483
Cdd:pfam00134  73 LQLVGVTCLFIAAKYEEIYPP--------TVEDLvyitdnAYTREEILRMERLILETLNF 124
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
386-540 4.60e-15

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 77.89  E-value: 4.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 386 LRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSERtLILVGIASLTLATRIEEnqpYNSIRKRNF-TIQNLR 464
Cdd:COG5024   212 MRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEK-YQLVGISALFIASKYEE---VNCPSIKDLvYATDGA 287

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063683417 465 YSRHEVVAMEWLVQEVLNFKCFTPTIFNFLWFYLKAARANPEVERKAKSLAVTSLSDQTQLCFWPSTVAAALVVLA 540
Cdd:COG5024   288 FTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLS 363
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 347-483 3.30e-14

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 69.58  E-value: 3.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 347 EEVEESYLRLRERERSHaymrdCAKAYCSRMDNTgLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKS 426
Cdd:cd20504     1 EYADDIYEYLRESELKH-----RPKPDYMRKQPD-INPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLR 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063683417 427 ERtLILVGIASLTLATRIEENQPYNSirKRNFTIQNLRYSRHEVVAMEWLVQEVLNF 483
Cdd:cd20504    75 SK-LQLVGTACMFIAAKYEEIYPPEV--EEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 347-483 7.38e-14

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 68.86  E-value: 7.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 347 EEVEESYLRLRERER----SHAYMrdcakaycsrMDNTGLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKG 422
Cdd:cd20568     7 EYVPEIFEYLRELELktlpNPNYM----------DDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKR 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063683417 423 SFKSERtLILVGIASLTLATRIEE-NQPynsirkrnfTIQNLRY------SRHEVVAMEWLVQEVLNF 483
Cdd:cd20568    77 VVSLNK-LQLVGISALFIASKYEEvNSP---------SIKNFAYmtdgayTVEDILRAERYMLNTLEF 134
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 387-483 6.22e-13

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 65.03  E-value: 6.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 387 RSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFkSERTLILVGIASLTLATRIEENQPyNSIRKRNFTIQNLrYS 466
Cdd:cd20542     1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKI-SLSLLQLLGITCLFIACKFEERFP-PEVATLCYLTDDS-YS 77

                          90
                  ....*....|....*..
gi 1063683417 467 RHEVVAMEWLVQEVLNF 483
Cdd:cd20542    78 KKQVLRMERRVLRRLRF 94
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 386-483 1.71e-12

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 64.69  E-value: 1.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 386 LRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSERtLILVGIASLTLATRIEENQPYNSirKRNFTIQNLRY 465
Cdd:cd20561    36 MRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGK-LQLVGTAAMLLASKFEEIYPPEV--AEFVYITDDTY 112

                          90
                  ....*....|....*...
gi 1063683417 466 SRHEVVAMEWLVQEVLNF 483
Cdd:cd20561   113 TKKQVLRMEHLVLKVLTF 130
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 350-449 2.15e-12

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 64.64  E-value: 2.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 350 EESYLRLRERERSHAYMRDCAKAYcsrmdnTGLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSERT 429
Cdd:cd20519     6 EEVWDLMLKKEELYKRDRDFLNRH------PSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKTQ 79

                          90       100
                  ....*....|....*....|
gi 1063683417 430 LILVGIASLTLATRIEENQP 449
Cdd:cd20519    80 LQLIGITCLFIAAKLEEIYP 99
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 385-483 7.90e-12

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 62.96  E-value: 7.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 385 RLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFkSERTLILVGIASLTLATRIEENqpYNSIRKRNFTIQNLR 464
Cdd:cd20566    38 RMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPV-SRKKLQLVGVTALLLASKYEEM--YSPEIGDFVYITDNA 114

                          90
                  ....*....|....*....
gi 1063683417 465 YSRHEVVAMEWLVQEVLNF 483
Cdd:cd20566   115 YTKAQIREMEMLILKELNF 133
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 347-483 2.07e-11

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 62.55  E-value: 2.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 347 EEVEESYLRLRERERSH----AYMRDcakaycsrmdNTGLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKG 422
Cdd:cd20560    35 EYAEDIHQYLREAELKHrpkpGYMRK----------QPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCM 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063683417 423 SFKSERtLILVGIASLTLATRIEENQPYNSirKRNFTIQNLRYSRHEVVAMEWLVQEVLNF 483
Cdd:cd20560   105 SVLRGK-LQLVGTAAILLASKYEEIYPPEV--DEFVYITDDTYTKKQLLRMEHLLLKVLAF 162
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 352-483 2.30e-11

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 61.89  E-value: 2.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 352 SYLRLRERE-RSHAYMrdcakaycsrMDNTGLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSERtL 430
Cdd:cd20508    22 DYMKEREEKfVVPDYL----------EKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKEK-L 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 431 ILVGIASLTLATRIEENQP-------YnsirkrnftIQNLRYSRHEVVAMEWLVQEVLNF 483
Cdd:cd20508    91 QLLGATAILIASKFDERCPpcvddflY---------ICDDAYTREELLKMEREILKTLDF 141
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 387-448 3.87e-10

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 56.94  E-value: 3.87e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063683417 387 RSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSERT--LILVGIASLTLATRIEENQ 448
Cdd:cd20543     2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKPwmLQLLAVACLSLAAKMEETD 65
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 384-484 3.88e-10

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 58.19  E-value: 3.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 384 PRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSkGSFKSERTLILVGIASLTLATRIEENQPynsIRKRNFT-IQN 462
Cdd:cd20562    39 PSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLS-GNYVNRQRLQLLGVSCMLIASKYEEICA---PQVEEFCyITD 114

                          90       100
                  ....*....|....*....|..
gi 1063683417 463 LRYSRHEVVAMEWLVQEVLNFK 484
Cdd:cd20562   115 NTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 347-483 6.46e-10

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 57.20  E-value: 6.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 347 EEVEESYLRLRERERSHAymrdCAKAYCSRMDNTGlipRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFkS 426
Cdd:cd20565     3 EYVKDIYAYLRQLEEEQA----VRPKYLEGQEVTG---NMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPV-P 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063683417 427 ERTLILVGIASLTLATRIEENQPyNSIRKRNFTIQNlRYSRHEVVAMEWLVQEVLNF 483
Cdd:cd20565    75 KKMLQLVGVTAMFIASKYEEMYP-PEIGDFAFVTDN-TYTKHQIRQMEMKILRALDF 129
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 385-483 7.12e-10

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 57.74  E-value: 7.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 385 RLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFkSERTLILVGIASLTLATRIEENQPynsIRKRNFT-IQNL 463
Cdd:cd20567    52 KMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQV-PRKELQLVGVTAMLIASKYEEIWA---PEVNDFVyISDN 127

                          90       100
                  ....*....|....*....|
gi 1063683417 464 RYSRHEVVAMEWLVQEVLNF 483
Cdd:cd20567   128 AYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 386-483 1.38e-09

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 55.69  E-value: 1.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 386 LRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFkSERTLILVGIASLTLATRIEE---NQPynSIRKRNFTIQN 462
Cdd:cd20528     6 LRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDI-SEDQLHLVALTCLLLAAKFEElddNIP--KISDLNRYLCN 82

                          90       100
                  ....*....|....*....|.
gi 1063683417 463 LRYSRHEVVAMEWLVQEVLNF 483
Cdd:cd20528    83 SVYSKQEYLQMELLILEFFQW 103
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 365-449 1.11e-08

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 54.11  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 365 YMRDcaKAYCSRMDNtgLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSERTLILVGIASLTLATRI 444
Cdd:cd20579    25 YLRD--KNFLQKHPL--LQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQENVVKTRLQLIGISSLFIAAKL 100


                  ....*
gi 1063683417 445 EENQP 449
Cdd:cd20579   101 EEIYP 105
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 387-449 1.30e-08

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 52.33  E-value: 1.30e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063683417 387 RSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSERtLILVGIASLTLATRIEENQP 449
Cdd:cd20536     2 RAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDC-FQLLGVTSLLIACKQEEIYP 63
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 488-570 2.12e-08

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 51.93  E-value: 2.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 488 PTIFNFLWFYLKAARANPEVERKAKSLAVTSLSDQTQLCFWPSTVAAALVVLACIEHNKISAYQRVIKVHVRTTDNELPE 567
Cdd:cd20537     1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGEPPPSPQLLQLVTGYSENDLQE 80


                  ...
gi 1063683417 568 CVK 570
Cdd:cd20537    81 CAK 83
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 488-570 1.18e-07

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 50.70  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 488 PTIFNFLWFYLKAARANP--EVERKAKSLAVTSLSDQTQLCFWPSTVAAALVVLACIEHNKiSAYQRVIKVHVRTTDNEL 565
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHdlELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNS-PEWTETLEHYTGYSEEDL 79


                  ....*
gi 1063683417 566 PECVK 570
Cdd:pfam02984  80 KPCVK 84
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 382-483 1.51e-07

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 50.62  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 382 LIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSERTLILVGIASLTLATRIEENQPYNsirkrnftIQ 461
Cdd:cd20580    38 LQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKNINKSMLQLIGITSLFIASKLEEIYPPK--------LH 109

                          90       100
                  ....*....|....*....|....*...
gi 1063683417 462 NLRY------SRHEVVAMEWLVQEVLNF 483
Cdd:cd20580   110 EFAYvtdgacSEDDILDMELIILKALKW 137
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 390-446 6.00e-07

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 47.41  E-value: 6.00e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063683417 390 MVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSeRTLILVGIASLTLATRIEE 446
Cdd:cd00043     2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLG-RSPELIAAACLYLACKLEE 57
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 346-481 7.59e-07

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 49.22  E-value: 7.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 346 DEEVEESYLRLRERERSHAYMRDCAKaycsrmdnTGLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFK 425
Cdd:cd20575    23 DQRVLQNLLRLEERYVPRVSYFQCVQ--------REIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTR 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063683417 426 SERtLILVGIASLTLATRIEENQPynsirkrnFTIQNL-RYSRHEVVAMEWLVQEVL 481
Cdd:cd20575    95 KAQ-LQLLGAVCMLLASKLRETTP--------LTIEKLcIYTDNSISPRQLLDWEIL 142
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 488-540 1.87e-06

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 46.86  E-value: 1.87e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063683417 488 PTIFNFLWFYLKAARANP---EVERKAKSLAVTSLSDQTQLCFWPSTVAAALVVLA 540
Cdd:cd20506     1 PTIKTFLRRFLRAAQASVpdlKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLA 56
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 382-477 4.04e-06

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 46.90  E-value: 4.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 382 LIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSERtLILVGIASLTLATRIEENQPYNSIRKRNFTIQ 461
Cdd:cd20573    50 ILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSR-LQLLGATCMFLASKMKETIPLTAEKLCIYTDN 128

                          90
                  ....*....|....*.
gi 1063683417 462 NLRysRHEVVAMEWLV 477
Cdd:cd20573   129 SIR--PEELLQMELLV 142
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 384-473 4.56e-06

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 45.38  E-value: 4.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 384 PRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSERtLILVGIASLTLATRIEEnQPYNSIRKRNFTIQNL 463
Cdd:cd20521     1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSK-LQLLGIACMVIATRFLG-KDILTIREAAWLTDNT 78

                          90
                  ....*....|
gi 1063683417 464 rYSRHEVVAM 473
Cdd:cd20521    79 -YKYEDVVRM 87
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 392-474 5.37e-06

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 44.89  E-value: 5.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417  392 QWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFkSERTLILVGIASLTLATRIEENQPYNSIRKRNFTIqnlrYSRHEVV 471
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKF-LKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY----FTEEEIL 75


                   ...
gi 1063683417  472 AME 474
Cdd:smart00385  76 RME 78
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 488-570 8.37e-06

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 45.37  E-value: 8.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 488 PTIFNFLWFYLKAARANPEVERKAKSLAVTSLSDQTQLCFWPSTVAAALVVLACIEHNKISAYQRVIKVHVRTTDNELPE 567
Cdd:cd20511     1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLNKTPEWTSTLEFHTGYSESQLME 80


                  ...
gi 1063683417 568 CVK 570
Cdd:cd20511    81 CAR 83
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 346-477 1.76e-05

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 44.98  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 346 DEEVEESYLRLRERershaYMRDCAKAYCSRMDntgLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSkGSFK 425
Cdd:cd20574    23 DDRVLQNLLTIEER-----YLPQCSYFKCVQKD---IQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLA-VVPT 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063683417 426 SERTLILVGIASLTLATRIEENQPYNSIRKRNFTIQNLRysRHEVVAMEWLV 477
Cdd:cd20574    94 RKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIK--PQELLEWELVV 143
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 387-446 1.55e-04

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 41.14  E-value: 1.55e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063683417 387 RSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSkgSFKSE-RTLILVGIASLTLATRIEE 446
Cdd:cd20526     2 RDEAVRWLAELNSQFKFYPETFALAVSILDRFLA--SVKARpKYLRCIAISCLFLAAKTNE 60
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 345-481 1.78e-03

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 39.20  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 345 DDEEVEESYLRLRERershaYMRDCAKAYCSRMDntgLIPRLRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSF 424
Cdd:cd20515    22 LDDRVLQNLLSLEER-----YLPSASYFKCVQTE---IQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPI 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063683417 425 KSERtLILVGIASLTLATRIEENQPynsirkrnFTIQNL-RYSRHEVVAMEWLVQEVL 481
Cdd:cd20515    94 RKSQ-LQLLGAVCLFLASKLKETIP--------LTAEKLcIYTDNSITLQELLDWELL 142
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 386-484 4.32e-03

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 37.11  E-value: 4.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063683417 386 LRSIMVQWIVKQCSDMGLQQETLFLGVGLLDRFLSKGSFKSeRTLILVGIASLTLATRIEENQPYNSIRKRNFTIQNLRY 465
Cdd:cd20583     1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQP-KHLGCVGLSCFYLAVKAIEEERNVPLATDLIRISQYRF 79

                          90
                  ....*....|....*....
gi 1063683417 466 SRHEVVAMEWLVQEVLNFK 484
Cdd:cd20583    80 TVSDMMRMEKIILEKLCWK 98
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 488-540 8.36e-03

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 36.34  E-value: 8.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063683417 488 PTIFNFLWFYLKAARANPEVERKAKSLAVTSLSD-QTQLCFWPSTVAAALVVLA 540
Cdd:cd20564     1 PTINQFLTQYFLHQQANCKVESLSMFLGELSLIDaDPYLKYLPSVIAAAAFHLA 54
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 489-560 9.65e-03

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 35.46  E-value: 9.65e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063683417 489 TIFNFLWFYLKAARANPEVERKAKSLAVTSLSDQTQLCFWPSTVAAALVVLACIEHNK---ISAYQRVIKVHVRT 560
Cdd:cd00043     1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELprtLKEIAKVSGVSEKE 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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